ATP13A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.26206147
2locomotory exploration behavior (GO:0035641)4.95116281
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.88527435
4layer formation in cerebral cortex (GO:0021819)4.57110072
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.41191331
6synaptic vesicle exocytosis (GO:0016079)4.16898220
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.07141061
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.02878323
9positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.98279148
10regulation of synapse structural plasticity (GO:0051823)3.92809816
11cerebellar granule cell differentiation (GO:0021707)3.92696771
12vocalization behavior (GO:0071625)3.90021167
13regulation of ARF protein signal transduction (GO:0032012)3.89176571
14regulation of synaptic vesicle exocytosis (GO:2000300)3.86277312
15sodium ion export (GO:0071436)3.85147841
16G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.80440763
17proline transport (GO:0015824)3.78738814
18glutamate secretion (GO:0014047)3.76333442
19exploration behavior (GO:0035640)3.74691269
20regulation of glutamate receptor signaling pathway (GO:1900449)3.74569184
21neuronal ion channel clustering (GO:0045161)3.70499588
22negative regulation of cell killing (GO:0031342)3.67483593
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.67483593
24clathrin coat assembly (GO:0048268)3.64477217
25amino acid import (GO:0043090)3.60815612
26regulation of synapse maturation (GO:0090128)3.54044875
27neurotransmitter secretion (GO:0007269)3.45409604
28protein localization to synapse (GO:0035418)3.45042974
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.43535443
30regulation of synaptic vesicle transport (GO:1902803)3.41785013
31cellular potassium ion homeostasis (GO:0030007)3.41265996
32protein retention in ER lumen (GO:0006621)3.39459888
33protein localization to endosome (GO:0036010)3.37929218
34semaphorin-plexin signaling pathway (GO:0071526)3.34779084
35establishment of mitochondrion localization (GO:0051654)3.31738913
36negative regulation of microtubule polymerization (GO:0031115)3.31700704
37regulation of ARF GTPase activity (GO:0032312)3.31661916
38activation of protein kinase A activity (GO:0034199)3.29192960
39mitochondrion transport along microtubule (GO:0047497)3.28844010
40establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.28844010
41negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.28507897
42cell-cell junction maintenance (GO:0045217)3.23333202
43positive regulation by organism of defense response of other organism involved in symbiotic interact3.20360577
44modulation by symbiont of host immune response (GO:0052553)3.20360577
45positive regulation by symbiont of host defense response (GO:0052509)3.20360577
46modulation by symbiont of host defense response (GO:0052031)3.20360577
47modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.20360577
48modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.20360577
49ionotropic glutamate receptor signaling pathway (GO:0035235)3.19090018
50regulation of early endosome to late endosome transport (GO:2000641)3.15599167
51activation of Rac GTPase activity (GO:0032863)3.15502074
52dendritic spine organization (GO:0097061)3.14301482
53neuron cell-cell adhesion (GO:0007158)3.13789604
54regulation of neuronal synaptic plasticity (GO:0048168)3.11735274
55maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.09753565
56adherens junction assembly (GO:0034333)3.09579622
57peptidyl-tyrosine autophosphorylation (GO:0038083)3.08682674
58glycine transport (GO:0015816)3.05108370
59B cell receptor signaling pathway (GO:0050853)3.04689547
60regulation of long-term neuronal synaptic plasticity (GO:0048169)3.03602362
61dendritic spine morphogenesis (GO:0060997)3.00711682
62gamma-aminobutyric acid transport (GO:0015812)2.99755154
63synaptic vesicle endocytosis (GO:0048488)2.99469272
64macrophage activation involved in immune response (GO:0002281)2.98310936
65cerebellar Purkinje cell differentiation (GO:0021702)2.96140963
66positive regulation of synapse maturation (GO:0090129)2.95752216
67regulation of vesicle fusion (GO:0031338)2.95586933
68axon cargo transport (GO:0008088)2.94120898
69neuromuscular process controlling balance (GO:0050885)2.94068773
70cell migration in hindbrain (GO:0021535)2.92092914
71positive regulation of gamma-delta T cell activation (GO:0046645)2.91358337
72alanine transport (GO:0032328)2.88371824
73protein targeting to plasma membrane (GO:0072661)2.88024707
74dendrite morphogenesis (GO:0048813)2.87548684
75potassium ion homeostasis (GO:0055075)2.86795784
76nerve growth factor signaling pathway (GO:0038180)2.86547703
77regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.81959464
78positive regulation of neurotransmitter transport (GO:0051590)2.81666379
79positive regulation of neurotransmitter secretion (GO:0001956)2.81529907
80positive regulation of dendritic spine development (GO:0060999)2.80980283
81cell-substrate adherens junction assembly (GO:0007045)2.79925441
82focal adhesion assembly (GO:0048041)2.79925441
83regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.79779349
84cytoskeletal anchoring at plasma membrane (GO:0007016)2.79702739
85hemidesmosome assembly (GO:0031581)2.77484986
86positive regulation of dendritic spine morphogenesis (GO:0061003)2.77379095
87signal complex assembly (GO:0007172)2.76386483
88regulation of NFAT protein import into nucleus (GO:0051532)2.76210620
89postsynaptic membrane organization (GO:0001941)2.74616910
90positive regulation of Rap GTPase activity (GO:0032854)2.74472246
91regulation of mammary gland epithelial cell proliferation (GO:0033599)2.74148072
92positive regulation of B cell differentiation (GO:0045579)2.74015806
93vesicle transport along microtubule (GO:0047496)2.70996845
94response to auditory stimulus (GO:0010996)2.70513768
95retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.70235473
96membrane depolarization during action potential (GO:0086010)2.69264338
97neuronal action potential propagation (GO:0019227)2.68816649
98positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.68083321
99regulation of Rap GTPase activity (GO:0032317)2.66988431
100neurotransmitter transport (GO:0006836)2.65189538
101positive regulation of synaptic transmission, GABAergic (GO:0032230)2.64397649
102cerebellar Purkinje cell layer development (GO:0021680)2.64233221
103positive regulation of protein dephosphorylation (GO:0035307)2.63568743
104barbed-end actin filament capping (GO:0051016)2.62912992
105cell-substrate junction assembly (GO:0007044)2.62732655
106regulation of interferon-beta biosynthetic process (GO:0045357)2.61732533
107dopamine receptor signaling pathway (GO:0007212)2.61600595
108regulation of neurotransmitter secretion (GO:0046928)2.60588166
109glutamate receptor signaling pathway (GO:0007215)2.60343271
110planar cell polarity pathway involved in neural tube closure (GO:0090179)2.60093701
111prepulse inhibition (GO:0060134)2.59635913
112positive regulation of fibroblast migration (GO:0010763)2.59620417
113long-term memory (GO:0007616)2.58664671
114synaptic transmission, glutamatergic (GO:0035249)2.56330912
115regulation of excitatory postsynaptic membrane potential (GO:0060079)2.55795557
116positive regulation of membrane potential (GO:0045838)2.53568994
117regulation of neurotransmitter levels (GO:0001505)2.53493686
118regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.52896091
119negative regulation of dendrite morphogenesis (GO:0050774)2.52205076
120cell communication involved in cardiac conduction (GO:0086065)2.51994099
121potassium ion import (GO:0010107)2.51099670
122negative regulation of synaptic transmission, GABAergic (GO:0032229)2.49595345
123organelle transport along microtubule (GO:0072384)2.49439560
124neuromuscular process controlling posture (GO:0050884)2.49324199
125membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.48811953
126neurotransmitter-gated ion channel clustering (GO:0072578)2.48632335
127mannose metabolic process (GO:0006013)2.48108689
128neuron recognition (GO:0008038)2.47723772
129mating behavior (GO:0007617)2.47690976
130adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.46603756
131cell communication by electrical coupling (GO:0010644)2.45884461
132regulation of postsynaptic membrane potential (GO:0060078)2.45859901
133dicarboxylic acid transport (GO:0006835)2.45803494
134L-serine transport (GO:0015825)2.45687646
135positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.45678464
136cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.45394771
137regulation of B cell receptor signaling pathway (GO:0050855)2.44783384
138detection of temperature stimulus involved in sensory perception (GO:0050961)2.44350308
139detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.44350308
140auditory behavior (GO:0031223)2.43649383
141cellular sodium ion homeostasis (GO:0006883)2.41382775
142response to pheromone (GO:0019236)2.41351043
143establishment of synaptic vesicle localization (GO:0097480)2.41317846
144synaptic vesicle transport (GO:0048489)2.41317846
145cell junction maintenance (GO:0034331)2.40398541
146L-amino acid import (GO:0043092)2.40304039
147regulation of synaptic plasticity (GO:0048167)2.40095108
148serine transport (GO:0032329)2.39736667

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.34554717
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.11405602
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.03978134
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.99852427
5IKZF1_21737484_ChIP-ChIP_HCT116_Human2.81024329
6DROSHA_22980978_ChIP-Seq_HELA_Human2.64578407
7* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.62886932
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.57998865
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.47201538
10MYC_22102868_ChIP-Seq_BL_Human2.40347126
11VDR_21846776_ChIP-Seq_THP-1_Human2.35020377
12* KDM2B_26808549_Chip-Seq_DND41_Human2.30529595
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.22649846
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.19868474
15REST_21632747_ChIP-Seq_MESCs_Mouse2.19802451
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.16006832
17LXR_22292898_ChIP-Seq_THP-1_Human2.12087079
18* RACK7_27058665_Chip-Seq_MCF-7_Human2.10060090
19GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.08208085
20SCL_19346495_ChIP-Seq_HPC-7_Human2.08088729
21* TCF7_22412390_ChIP-Seq_EML_Mouse2.07358857
22SPI1_23127762_ChIP-Seq_K562_Human2.06152697
23SRY_22984422_ChIP-ChIP_TESTIS_Rat2.05193366
24* KDM2B_26808549_Chip-Seq_K562_Human2.03655543
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.93655600
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.93401938
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93062983
28* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.90934340
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88582990
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88552688
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88521729
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.87186551
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86040162
34EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.84402746
35* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.83622821
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.82195109
37* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81106778
38* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.80824874
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.79728693
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77870884
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76358450
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74721508
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74332071
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74332071
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72540320
46* KDM2B_26808549_Chip-Seq_JURKAT_Human1.72422521
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70776535
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69231611
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.66880956
50VDR_24763502_ChIP-Seq_THP-1_Human1.66495908
51* TET1_21451524_ChIP-Seq_MESCs_Mouse1.66430753
52STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65893634
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.63777067
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.57363934
55* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56939302
56ZNF263_19887448_ChIP-Seq_K562_Human1.56277692
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.56270074
58* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53333138
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53156097
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.51436385
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50926497
62* IRF8_27001747_Chip-Seq_BMDM_Mouse1.50800924
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46201642
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44876363
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44822107
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.43347988
67IRF8_22096565_ChIP-ChIP_GC-B_Human1.43089831
68* GATA1_19941827_ChIP-Seq_MEL_Mouse1.42371607
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42092616
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.41152231
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40075423
72SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39004888
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38909528
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38551721
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36139509
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33938385
77* ELK3_25401928_ChIP-Seq_HUVEC_Human1.33375152
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32063734
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28511895
80* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23881056
81NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22677236
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22365711
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20056424
84UTX_26944678_Chip-Seq_JUKART_Human1.19363895
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19059964
86PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18598476
87AR_21572438_ChIP-Seq_LNCaP_Human1.18245946
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18025224
89* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15969705
90* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15953131
91* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15375030
92* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.14807246
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14406559
94MAF_26560356_Chip-Seq_TH1_Human1.14215407
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14081565
96RUNX_20019798_ChIP-Seq_JUKART_Human1.14052242
97* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.13694932
98EZH2_27304074_Chip-Seq_ESCs_Mouse1.12314239
99GATA1_19941826_ChIP-Seq_K562_Human1.11815975
100TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.11703819
101TP53_22127205_ChIP-Seq_IMR90_Human1.11146944
102TRIM28_21343339_ChIP-Seq_HEK293_Human1.11145090
103SMC4_20622854_ChIP-Seq_HELA_Human1.10440376
104* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09692297
105RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08884508
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07575433
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07103268
108* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06424926
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06081071
110OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05504813
111EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04803098
112CLOCK_20551151_ChIP-Seq_293T_Human1.04274412
113TP63_22573176_ChIP-Seq_HFKS_Human1.03434505
114JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03024051
115* SA1_27219007_Chip-Seq_Bcells_Human1.02721234
116* RUNX1_22412390_ChIP-Seq_EML_Mouse1.02358166
117* TET1_21490601_ChIP-Seq_MESCs_Mouse1.01840164
118RING1B_27294783_Chip-Seq_ESCs_Mouse1.01718018
119GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01573942
120P68_20966046_ChIP-Seq_HELA_Human1.01139612
121MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00854374
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00029514
123* CTCF_27219007_Chip-Seq_Bcells_Human0.99842230
124* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97944867
125* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97692350
126FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97462688
127ELF1_20517297_ChIP-Seq_JURKAT_Human0.92995375
128* SA1_27219007_Chip-Seq_ERYTHROID_Human0.92248915
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91702702
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91565573
131* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89727408
132* CREB1_26743006_Chip-Seq_LNCaP_Human0.89439317
133* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89342323
134GBX2_23144817_ChIP-Seq_PC3_Human0.87621915
135AR_19668381_ChIP-Seq_PC3_Human0.87043368
136RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86923577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.76578239
2MP0000569_abnormal_digit_pigmentation4.02686240
3MP0003635_abnormal_synaptic_transmissio3.21049517
4MP0003172_abnormal_lysosome_physiology3.08630725
5MP0003705_abnormal_hypodermis_morpholog2.99578203
6MP0003880_abnormal_central_pattern2.69250045
7MP0005423_abnormal_somatic_nervous2.68357875
8MP0004858_abnormal_nervous_system2.65036841
9MP0004270_analgesia2.64396221
10MP0001968_abnormal_touch/_nociception2.63475301
11MP0003303_peritoneal_inflammation2.62480180
12MP0002064_seizures2.42923780
13MP0002735_abnormal_chemical_nociception2.38591333
14MP0001849_ear_inflammation2.36564641
15MP0002063_abnormal_learning/memory/cond2.33832489
16MP0009745_abnormal_behavioral_response2.29728349
17MP0005058_abnormal_lysosome_morphology2.16167761
18MP0009046_muscle_twitch2.15997393
19MP0002736_abnormal_nociception_after2.13061198
20MP0005174_abnormal_tail_pigmentation2.12479690
21MP0002733_abnormal_thermal_nociception2.08295887
22MP0002734_abnormal_mechanical_nocicepti2.02431275
23MP0009780_abnormal_chondrocyte_physiolo1.98205956
24MP0004510_myositis1.94272890
25MP0002572_abnormal_emotion/affect_behav1.87966738
26MP0004811_abnormal_neuron_physiology1.87903438
27MP0005623_abnormal_meninges_morphology1.86418710
28MP0008961_abnormal_basal_metabolism1.85591441
29MP0001970_abnormal_pain_threshold1.85170895
30MP0002909_abnormal_adrenal_gland1.83897105
31MP0000579_abnormal_nail_morphology1.82865986
32MP0003329_amyloid_beta_deposits1.80221669
33MP0008569_lethality_at_weaning1.78672405
34MP0003183_abnormal_peptide_metabolism1.75644968
35MP0003566_abnormal_cell_adhesion1.69945012
36MP0003123_paternal_imprinting1.69500553
37MP0000537_abnormal_urethra_morphology1.68432312
38MP0000678_abnormal_parathyroid_gland1.67146377
39MP0008260_abnormal_autophagy1.65090479
40MP0002877_abnormal_melanocyte_morpholog1.63430807
41MP0000015_abnormal_ear_pigmentation1.58956716
42MP0000604_amyloidosis1.57832262
43MP0000566_synostosis1.55124949
44MP0003300_gastrointestinal_ulcer1.53101127
45MP0002249_abnormal_larynx_morphology1.52012963
46MP0002272_abnormal_nervous_system1.51587154
47MP0000955_abnormal_spinal_cord1.50875868
48MP0002067_abnormal_sensory_capabilities1.47863238
49MP0002184_abnormal_innervation1.47677674
50MP0003879_abnormal_hair_cell1.47466205
51MP0001486_abnormal_startle_reflex1.42901227
52MP0009278_abnormal_bone_marrow1.39001282
53MP0000778_abnormal_nervous_system1.36998142
54MP0002796_impaired_skin_barrier1.36075938
55MP0001501_abnormal_sleep_pattern1.35515849
56MP0004885_abnormal_endolymph1.33596505
57MP0002557_abnormal_social/conspecific_i1.31313433
58MP0005464_abnormal_platelet_physiology1.30007855
59MP0001835_abnormal_antigen_presentation1.29928416
60MP0003690_abnormal_glial_cell1.29536284
61MP0003633_abnormal_nervous_system1.28021862
62MP0003075_altered_response_to1.25536128
63MP0001440_abnormal_grooming_behavior1.24575367
64MP0003787_abnormal_imprinting1.20900012
65MP0004924_abnormal_behavior1.18214616
66MP0005386_behavior/neurological_phenoty1.18214616
67MP0003453_abnormal_keratinocyte_physiol1.13716942
68MP0006276_abnormal_autonomic_nervous1.11914318
69MP0003283_abnormal_digestive_organ1.11645624
70MP0002882_abnormal_neuron_morphology1.11311119
71MP0001905_abnormal_dopamine_level1.10110116
72MP0003634_abnormal_glial_cell1.09061382
73MP0002822_catalepsy1.07504384
74MP0002066_abnormal_motor_capabilities/c1.04470959
75MP0001800_abnormal_humoral_immune1.04194353
76MP0005076_abnormal_cell_differentiation1.03966552
77MP0001346_abnormal_lacrimal_gland1.03440789
78MP0005645_abnormal_hypothalamus_physiol1.02861579
79MP0000465_gastrointestinal_hemorrhage1.00643003
80MP0005257_abnormal_intraocular_pressure1.00229147
81MP0004272_abnormal_basement_membrane0.98686249
82MP0000371_diluted_coat_color0.98579185
83MP0005387_immune_system_phenotype0.97141208
84MP0001790_abnormal_immune_system0.97141208
85MP0002090_abnormal_vision0.96294819
86MP0002452_abnormal_antigen_presenting0.96280416
87MP0002095_abnormal_skin_pigmentation0.95874961
88MP0008874_decreased_physiological_sensi0.95321287
89MP0003631_nervous_system_phenotype0.94508265
90MP0000372_irregular_coat_pigmentation0.93714831
91MP0000751_myopathy0.92878404
92MP0003191_abnormal_cellular_cholesterol0.92637238
93MP0001188_hyperpigmentation0.91502744
94MP0005000_abnormal_immune_tolerance0.90619177
95MP0002419_abnormal_innate_immunity0.89468916
96MP0002229_neurodegeneration0.89320604
97MP0009672_abnormal_birth_weight0.88383465
98MP0000462_abnormal_digestive_system0.87967163
99MP0003436_decreased_susceptibility_to0.87459116
100MP0003091_abnormal_cell_migration0.86710299
101MP0002152_abnormal_brain_morphology0.86300968
102MP0000003_abnormal_adipose_tissue0.86037423
103MP0003632_abnormal_nervous_system0.85524723
104MP0002420_abnormal_adaptive_immunity0.84720966
105MP0005409_darkened_coat_color0.83155081
106MP0001819_abnormal_immune_cell0.82918213
107MP0005501_abnormal_skin_physiology0.82760161
108MP0002089_abnormal_postnatal_growth/wei0.81129731
109MP0004130_abnormal_muscle_cell0.80953393
110MP0000685_abnormal_immune_system0.80780272
111MP0003861_abnormal_nervous_system0.80687369
112MP0001177_atelectasis0.79491062
113MP0000467_abnormal_esophagus_morphology0.79050816
114MP0002723_abnormal_immune_serum0.78939473
115MP0002398_abnormal_bone_marrow0.78873642
116MP0002396_abnormal_hematopoietic_system0.77743673
117MP0005167_abnormal_blood-brain_barrier0.77732791
118MP0001348_abnormal_lacrimal_gland0.77728547
119MP0000920_abnormal_myelination0.75548842
120MP0010234_abnormal_vibrissa_follicle0.75230451
121MP0009840_abnormal_foam_cell0.74596006
122MP0005166_decreased_susceptibility_to0.74038478
123MP0003122_maternal_imprinting0.73874620
124MP0004233_abnormal_muscle_weight0.73872470
125MP0001502_abnormal_circadian_rhythm0.73755755
126MP0000681_abnormal_thyroid_gland0.73491472
127MP0010386_abnormal_urinary_bladder0.71830628
128MP0004142_abnormal_muscle_tone0.70948155
129MP0005310_abnormal_salivary_gland0.70629718
130MP0001545_abnormal_hematopoietic_system0.70274970
131MP0005397_hematopoietic_system_phenotyp0.70274970
132MP0004808_abnormal_hematopoietic_stem0.68407021
133MP0000762_abnormal_tongue_morphology0.68222494
134MP0000747_muscle_weakness0.68005762
135MP0004947_skin_inflammation0.66764838
136MP0010030_abnormal_orbit_morphology0.66447447
137MP0001984_abnormal_olfaction0.65809545
138MP0000716_abnormal_immune_system0.65501036
139MP0001943_abnormal_respiration0.64588543
140MP0000534_abnormal_ureter_morphology0.63554428
141MP0001299_abnormal_eye_distance/0.62261513
142MP0004782_abnormal_surfactant_physiolog0.61283777
143MP0010769_abnormal_survival0.60599216

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.29555427
2Visual hallucinations (HP:0002367)4.16191467
3Mutism (HP:0002300)4.04021858
4Obstructive sleep apnea (HP:0002870)3.89571019
5Increased cerebral lipofuscin (HP:0011813)3.81296904
6* Supranuclear gaze palsy (HP:0000605)3.67958279
7Papilledema (HP:0001085)3.54995824
8Hyperacusis (HP:0010780)3.52546436
9Focal seizures (HP:0007359)3.43494407
10Limb dystonia (HP:0002451)3.26626339
11Apathy (HP:0000741)3.19887396
12Ankle clonus (HP:0011448)3.18616522
13Focal motor seizures (HP:0011153)3.15449884
14Cellulitis (HP:0100658)3.07750413
15Diminished motivation (HP:0000745)3.03927261
16Neuronal loss in central nervous system (HP:0002529)2.90879176
17Disinhibition (HP:0000734)2.86537229
18Annular pancreas (HP:0001734)2.84963393
19Inappropriate behavior (HP:0000719)2.84804622
20Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.83352575
21Insomnia (HP:0100785)2.79674204
22Loss of speech (HP:0002371)2.77293181
23Dysostosis multiplex (HP:0000943)2.75974204
24Increased neuronal autofluorescent lipopigment (HP:0002074)2.73828009
25Cerebral aneurysm (HP:0004944)2.68302060
26Shallow orbits (HP:0000586)2.64404785
27Abnormality of liposaccharide metabolism (HP:0010968)2.61958777
28Abnormality of glycosphingolipid metabolism (HP:0004343)2.61958777
29Abnormality of glycolipid metabolism (HP:0010969)2.61958777
30Recurrent abscess formation (HP:0002722)2.61031005
31Action tremor (HP:0002345)2.59453436
32Urinary bladder sphincter dysfunction (HP:0002839)2.57967636
33Depression (HP:0000716)2.57533164
34Diplopia (HP:0000651)2.55478452
35Abnormality of binocular vision (HP:0011514)2.55478452
36Bronchomalacia (HP:0002780)2.54117694
37Distal lower limb amyotrophy (HP:0008944)2.52245709
38Cerebral inclusion bodies (HP:0100314)2.50682282
39Turricephaly (HP:0000262)2.49360245
40Pointed chin (HP:0000307)2.48176839
41Urinary urgency (HP:0000012)2.45131734
42Verrucae (HP:0200043)2.43624526
43Papilloma (HP:0012740)2.43624526
44Colitis (HP:0002583)2.41457088
45Agammaglobulinemia (HP:0004432)2.40842810
46Neurofibrillary tangles (HP:0002185)2.40662967
47Recurrent bacterial skin infections (HP:0005406)2.40400048
48Broad face (HP:0000283)2.37057717
49Aplasia involving bones of the extremities (HP:0009825)2.35923814
50Aplasia involving bones of the upper limbs (HP:0009823)2.35923814
51Aplasia of the phalanges of the hand (HP:0009802)2.35923814
52Hemiplegia (HP:0002301)2.34766368
53Macroorchidism (HP:0000053)2.32532526
54Difficulty climbing stairs (HP:0003551)2.31852874
55Truncal ataxia (HP:0002078)2.31158674
56Progressive cerebellar ataxia (HP:0002073)2.31010926
57Elfin facies (HP:0004428)2.30461829
58Peripheral hypomyelination (HP:0007182)2.29938980
59Ocular albinism (HP:0001107)2.24868923
60Stereotypic behavior (HP:0000733)2.24661894
61Abnormality of polysaccharide metabolism (HP:0011012)2.21868615
62Abnormality of glycosaminoglycan metabolism (HP:0004371)2.21868615
63Abnormality of mucopolysaccharide metabolism (HP:0011020)2.21868615
64Stridor (HP:0010307)2.21616822
65Amyotrophic lateral sclerosis (HP:0007354)2.20939203
66Progressive inability to walk (HP:0002505)2.19951061
67Mucopolysacchariduria (HP:0008155)2.19048395
68Urinary glycosaminoglycan excretion (HP:0003541)2.19048395
69Dysmetria (HP:0001310)2.18872750
70Iris hypopigmentation (HP:0007730)2.14764287
71Abnormality of the lower motor neuron (HP:0002366)2.14167210
72Spastic gait (HP:0002064)2.12735871
73Protrusio acetabuli (HP:0003179)2.12562828
74Poor eye contact (HP:0000817)2.08991266
75Gastrointestinal inflammation (HP:0004386)2.08343225
76Impaired smooth pursuit (HP:0007772)2.06932356
77Epileptic encephalopathy (HP:0200134)2.05752771
78Abnormal social behavior (HP:0012433)2.05683153
79Impaired social interactions (HP:0000735)2.05683153
80Long palpebral fissure (HP:0000637)2.04763436
81Generalized tonic-clonic seizures (HP:0002069)2.04395835
82Abnormal eating behavior (HP:0100738)2.04210226
83Agitation (HP:0000713)2.03800023
84Atrophic scars (HP:0001075)2.03544554
85Ulnar bowing (HP:0003031)2.02256983
86Impaired vibration sensation in the lower limbs (HP:0002166)2.01722897
87Achilles tendon contracture (HP:0001771)2.00691151
88Absence seizures (HP:0002121)1.99497550
89Hyperparathyroidism (HP:0000843)1.99150840
90Febrile seizures (HP:0002373)1.98788470
91* Rigidity (HP:0002063)1.97658880
92Inflammation of the large intestine (HP:0002037)1.97360081
93Ankyloglossia (HP:0010296)1.96431443
94J-shaped sella turcica (HP:0002680)1.96425178
95Premature rupture of membranes (HP:0001788)1.95397693
96Cerebral hypomyelination (HP:0006808)1.93557840
97Broad distal phalanx of finger (HP:0009836)1.93497814
98Tetraplegia (HP:0002445)1.92444469
99Hand muscle atrophy (HP:0009130)1.91652920
100Hammertoe (HP:0001765)1.90009344
101Chronic otitis media (HP:0000389)1.89781874
102Atonic seizures (HP:0010819)1.89480852
103Fragile skin (HP:0001030)1.88836549
104Insidious onset (HP:0003587)1.88736258
105Termporal pattern (HP:0011008)1.88736258
106Overriding aorta (HP:0002623)1.87747018
107Enlarged penis (HP:0000040)1.86258480
108Truncus arteriosus (HP:0001660)1.86114147
109Abnormality of ocular smooth pursuit (HP:0000617)1.86070818
110Dialeptic seizures (HP:0011146)1.84969139
111Abnormality of the periventricular white matter (HP:0002518)1.84750943
112* Torticollis (HP:0000473)1.84395633
113Bowel incontinence (HP:0002607)1.83512534
114Drooling (HP:0002307)1.83250235
115Excessive salivation (HP:0003781)1.83250235
116* Postural instability (HP:0002172)1.82708338
117Bradykinesia (HP:0002067)1.82604011
118Axonal loss (HP:0003447)1.82084367
119Disproportionate tall stature (HP:0001519)1.81820475
120Hypercortisolism (HP:0001578)1.81345412
121Sleep apnea (HP:0010535)1.80421221
122* Distal sensory impairment (HP:0002936)1.80310551
123Genetic anticipation (HP:0003743)1.79565487
124Deformed sella turcica (HP:0002681)1.79454279
125Frequent falls (HP:0002359)1.78519814
126Lower limb muscle weakness (HP:0007340)1.78467448
127Generalized hypotonia (HP:0001290)1.78315353
128Lower limb amyotrophy (HP:0007210)1.78179731
129Growth hormone excess (HP:0000845)1.77294602
130Abnormality of the corticospinal tract (HP:0002492)1.77170091
131Abnormality of the thoracic spine (HP:0100711)1.77040347
132Generalized hypopigmentation (HP:0007513)1.76818131
133Mitral regurgitation (HP:0001653)1.76510285
134Dysmetric saccades (HP:0000641)1.75138083
135Large eyes (HP:0001090)1.75127384
136Increased connective tissue (HP:0009025)1.75098683
137* Rapidly progressive (HP:0003678)1.74676510
138Open mouth (HP:0000194)1.74591828
139Interstitial pulmonary disease (HP:0006530)1.74040702
140Centrally nucleated skeletal muscle fibers (HP:0003687)1.73989064
141Thoracic kyphosis (HP:0002942)1.73680988
142Spinal cord compression (HP:0002176)1.73564956
143Upper limb amyotrophy (HP:0009129)1.72949482
144Distal upper limb amyotrophy (HP:0007149)1.72949482
145Spinal canal stenosis (HP:0003416)1.72585892
146Cholecystitis (HP:0001082)1.72092634
147Abnormal gallbladder physiology (HP:0012438)1.72092634
148Thin bony cortex (HP:0002753)1.69561399
149Intention tremor (HP:0002080)1.69273937
150Arnold-Chiari malformation (HP:0002308)1.68983156
151Abnormal large intestine physiology (HP:0012700)1.68699012
152Hypoventilation (HP:0002791)1.66928719
153Abnormality of the Achilles tendon (HP:0005109)1.65835626
154Onion bulb formation (HP:0003383)1.65040515
155Decreased motor nerve conduction velocity (HP:0003431)1.64540982
156Lower limb asymmetry (HP:0100559)1.64450841
157Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.63769895
158Distal lower limb muscle weakness (HP:0009053)1.62933976
159Vertebral compression fractures (HP:0002953)1.60840823
160Short nail (HP:0001799)1.60406289
161Foot dorsiflexor weakness (HP:0009027)1.60217422
162Precocious puberty (HP:0000826)1.59471074

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.35401280
2MARK13.30709462
3SIK22.81626993
4RIPK42.65592366
5TRIB32.64630937
6EEF2K2.59107211
7MAP3K102.56856104
8PKN22.47913978
9NTRK32.45190108
10PRPF4B2.42740199
11SIK12.40416570
12SMG12.23914946
13DAPK22.20797315
14MINK12.20729129
15SCYL22.20024274
16CAMKK12.08492905
17FES2.07128115
18EPHA22.00493086
19KSR21.99189209
20ARAF1.96459349
21NTRK21.92142106
22PAK61.83461271
23LATS21.82479118
24MAP3K41.82181915
25NTRK11.78945867
26RIPK11.70011319
27MAP4K11.65943072
28CAMK1G1.65607021
29ERN11.65580678
30MAP3K111.53589708
31TESK11.46976180
32EPHA41.37853121
33RET1.37374039
34KIT1.34316089
35SYK1.32045183
36IRAK31.28946363
37CDK51.23810724
38TAOK11.22907302
39RPS6KA21.19098407
40DAPK11.17778905
41CAMK1D1.17434029
42FGFR41.14549664
43ALK1.14138680
44MAPK131.13521496
45TESK21.12508416
46PDGFRA1.11631101
47MATK1.11270645
48BLK1.11264196
49CDK121.10239146
50MAP2K71.09719348
51MST1R1.09570237
52MAP2K41.08116282
53PTK21.07462064
54GRK61.06397715
55MARK21.06160243
56KSR11.05838250
57PRKCH1.05571554
58MAP3K21.02283979
59BRAF1.01065468
60HCK0.97855551
61CSF1R0.97627392
62MAP3K130.96421422
63PRKD30.96303297
64CAMK2B0.94893132
65PRKG20.91225224
66PTK60.89896417
67CDK190.88359559
68PHKG10.86552860
69PHKG20.86552860
70UHMK10.86223713
71PAK40.85377641
72EPHB20.83526058
73TNK20.82821514
74BTK0.80931879
75ICK0.79045976
76CSNK1G20.77620177
77TTN0.76638189
78GRK50.75184141
79CAMK10.74726302
80PDK10.73979960
81MAP3K70.73290643
82LIMK10.73018119
83FYN0.72562599
84STK110.71717505
85CAMK2G0.70017767
86SGK30.69907994
87CAMKK20.69133173
88EPHB10.69026270
89MTOR0.67005290
90PRKD20.65899157
91TBK10.65375861
92NME20.65045846
93MET0.64847447
94TYRO30.63966181
95MAPK120.63576785
96CDK150.62986662
97HIPK20.60516749
98MAP3K120.60080789
99CDK180.59351405
100STK380.57219333
101CDK140.57163112
102CDK11A0.56885093
103MAP3K10.56551688
104PDPK10.56540631
105LMTK20.55442733
106CLK10.54227565
107RAF10.53349279
108TAOK20.53282206
109PRKCG0.51495011
110BRSK10.51118277
111IRAK20.50735686
112FGR0.50623518
113PRKCZ0.49548751
114ROCK20.48636947
115MAP3K60.47616613
116MAPK100.47431873
117SGK2230.47190707
118SGK4940.47190707
119JAK20.46204240
120BMX0.45651573
121CASK0.45363883
122NEK60.45154316
123MAPKAPK50.44939344
124LRRK20.44310874
125MAP2K20.43688767
126MOS0.43307849
127JAK10.42973239
128CAMK40.42619145
129TNIK0.42413454
130MAPK40.40284710
131TAOK30.39472074
132SRC0.38716275
133LYN0.36717464
134DYRK1A0.36577809
135MARK30.36355994
136CAMK2D0.35851000
137CSNK1G30.35335150
138LCK0.34570871
139ZAP700.33855756
140DAPK30.32960487
141CDC42BPA0.32458862

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.61749697
2Olfactory transduction_Homo sapiens_hsa047402.18723545
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11998822
4B cell receptor signaling pathway_Homo sapiens_hsa046621.92627502
5Long-term potentiation_Homo sapiens_hsa047201.72884527
6Circadian entrainment_Homo sapiens_hsa047131.72579465
7Nicotine addiction_Homo sapiens_hsa050331.69728886
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.68066152
9Morphine addiction_Homo sapiens_hsa050321.63047354
10Glutamatergic synapse_Homo sapiens_hsa047241.60170419
11Glioma_Homo sapiens_hsa052141.56203216
12GABAergic synapse_Homo sapiens_hsa047271.54394360
13Cholinergic synapse_Homo sapiens_hsa047251.52894849
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.52566545
15Neurotrophin signaling pathway_Homo sapiens_hsa047221.51189851
16Dopaminergic synapse_Homo sapiens_hsa047281.50582838
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47004690
18Salivary secretion_Homo sapiens_hsa049701.46699324
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44299095
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44246257
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43704880
22Gastric acid secretion_Homo sapiens_hsa049711.40966098
23Type II diabetes mellitus_Homo sapiens_hsa049301.37832193
24Vitamin B6 metabolism_Homo sapiens_hsa007501.33354691
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.32074849
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29382058
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.28188653
28Insulin secretion_Homo sapiens_hsa049111.27648358
29Non-small cell lung cancer_Homo sapiens_hsa052231.27442117
30Prion diseases_Homo sapiens_hsa050201.27307207
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26753209
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25904945
33Amphetamine addiction_Homo sapiens_hsa050311.25777792
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24535395
35Estrogen signaling pathway_Homo sapiens_hsa049151.23135108
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22862296
37Lysosome_Homo sapiens_hsa041421.22374484
38GnRH signaling pathway_Homo sapiens_hsa049121.20414447
39Osteoclast differentiation_Homo sapiens_hsa043801.19843912
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19176213
41VEGF signaling pathway_Homo sapiens_hsa043701.18646977
42Oxytocin signaling pathway_Homo sapiens_hsa049211.18313200
43Chronic myeloid leukemia_Homo sapiens_hsa052201.14487123
44Renin secretion_Homo sapiens_hsa049241.12237492
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.11886404
46ErbB signaling pathway_Homo sapiens_hsa040121.11334921
47Long-term depression_Homo sapiens_hsa047301.09920235
48Cocaine addiction_Homo sapiens_hsa050301.08494124
49Gap junction_Homo sapiens_hsa045401.06416253
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04869432
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04349172
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03803333
53mTOR signaling pathway_Homo sapiens_hsa041501.03252900
54Pancreatic secretion_Homo sapiens_hsa049721.02065957
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00485210
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98970551
57Tuberculosis_Homo sapiens_hsa051520.98900854
58Chemokine signaling pathway_Homo sapiens_hsa040620.98807531
59Platelet activation_Homo sapiens_hsa046110.97955221
60Endometrial cancer_Homo sapiens_hsa052130.97479806
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96756656
62Calcium signaling pathway_Homo sapiens_hsa040200.95237450
63Endocytosis_Homo sapiens_hsa041440.94541127
64Colorectal cancer_Homo sapiens_hsa052100.91262224
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88783802
66cAMP signaling pathway_Homo sapiens_hsa040240.88333778
67Taste transduction_Homo sapiens_hsa047420.87708759
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86790636
69Axon guidance_Homo sapiens_hsa043600.86735458
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.85485698
71Collecting duct acid secretion_Homo sapiens_hsa049660.84689988
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84611229
73Serotonergic synapse_Homo sapiens_hsa047260.84080776
74Thyroid hormone synthesis_Homo sapiens_hsa049180.83769652
75Dorso-ventral axis formation_Homo sapiens_hsa043200.83633768
76Leishmaniasis_Homo sapiens_hsa051400.81734880
77Choline metabolism in cancer_Homo sapiens_hsa052310.81708534
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80583987
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80168584
80Prolactin signaling pathway_Homo sapiens_hsa049170.79817336
81Renal cell carcinoma_Homo sapiens_hsa052110.79309091
82Melanogenesis_Homo sapiens_hsa049160.78983899
83Bladder cancer_Homo sapiens_hsa052190.78794362
84Acute myeloid leukemia_Homo sapiens_hsa052210.78649494
85Pancreatic cancer_Homo sapiens_hsa052120.78368827
86AMPK signaling pathway_Homo sapiens_hsa041520.76436608
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75991221
88Other glycan degradation_Homo sapiens_hsa005110.74640071
89Focal adhesion_Homo sapiens_hsa045100.73988084
90Insulin signaling pathway_Homo sapiens_hsa049100.73925692
91MAPK signaling pathway_Homo sapiens_hsa040100.72620478
92Salmonella infection_Homo sapiens_hsa051320.71932904
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71894204
94Inositol phosphate metabolism_Homo sapiens_hsa005620.71622175
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70891027
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69241264
97Thyroid cancer_Homo sapiens_hsa052160.68085860
98ECM-receptor interaction_Homo sapiens_hsa045120.67849347
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.66914149
100Pertussis_Homo sapiens_hsa051330.65691525
101Fructose and mannose metabolism_Homo sapiens_hsa000510.65453324
102Vibrio cholerae infection_Homo sapiens_hsa051100.64902276
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63974054
104Tight junction_Homo sapiens_hsa045300.63392266
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62004583
106Hippo signaling pathway_Homo sapiens_hsa043900.61814444
107Dilated cardiomyopathy_Homo sapiens_hsa054140.61248742
108Ras signaling pathway_Homo sapiens_hsa040140.61167461
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.60742724
110Pentose phosphate pathway_Homo sapiens_hsa000300.60610469
111Adherens junction_Homo sapiens_hsa045200.60285239
112Biosynthesis of amino acids_Homo sapiens_hsa012300.60192980
113Galactose metabolism_Homo sapiens_hsa000520.59926632
114T cell receptor signaling pathway_Homo sapiens_hsa046600.59727946
115Glucagon signaling pathway_Homo sapiens_hsa049220.59128403
116Rap1 signaling pathway_Homo sapiens_hsa040150.59102421
117Shigellosis_Homo sapiens_hsa051310.58830001
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58286660
119Phagosome_Homo sapiens_hsa041450.58229902
120Bile secretion_Homo sapiens_hsa049760.57260249
121Notch signaling pathway_Homo sapiens_hsa043300.56928405
122Proteoglycans in cancer_Homo sapiens_hsa052050.55787399
123Alcoholism_Homo sapiens_hsa050340.55729065
1242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55021016
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52435775

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