ATP13A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ATP13A3 is a member of the P-type ATPase family of proteins that transport a variety of cations across membranes. Other P-type ATPases include ATP7B (MIM 606882) and ATP7A (MIM 300011). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)5.30614901
2positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.42914016
3protein localization to endosome (GO:0036010)4.33004713
4regulation of vitamin metabolic process (GO:0030656)4.24568357
5positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.15571279
6nuclear pore complex assembly (GO:0051292)4.05747005
7cysteine metabolic process (GO:0006534)4.05229604
8regulation of mononuclear cell migration (GO:0071675)3.94381840
9negative regulation of fibrinolysis (GO:0051918)3.91667991
10urea cycle (GO:0000050)3.85345449
11urea metabolic process (GO:0019627)3.85345449
12regulation of membrane protein ectodomain proteolysis (GO:0051043)3.80414439
13peptidyl-glutamic acid carboxylation (GO:0017187)3.79449494
14protein carboxylation (GO:0018214)3.79449494
15alpha-linolenic acid metabolic process (GO:0036109)3.73563753
16response to peptidoglycan (GO:0032494)3.72798969
17glycine metabolic process (GO:0006544)3.71462879
18nuclear pore organization (GO:0006999)3.69699002
19oligosaccharide catabolic process (GO:0009313)3.69402790
20serine family amino acid catabolic process (GO:0009071)3.64870016
21regulation of cholesterol homeostasis (GO:2000188)3.62814666
22glycosphingolipid catabolic process (GO:0046479)3.58925694
23lipopolysaccharide-mediated signaling pathway (GO:0031663)3.57208313
24erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.51113202
25L-phenylalanine catabolic process (GO:0006559)3.51113202
26homocysteine metabolic process (GO:0050667)3.46982615
27lysine catabolic process (GO:0006554)3.46196126
28lysine metabolic process (GO:0006553)3.46196126
29regulation of protein activation cascade (GO:2000257)3.45363941
30skin morphogenesis (GO:0043589)3.41682621
31negative regulation of interleukin-12 production (GO:0032695)3.41388497
32sulfur amino acid catabolic process (GO:0000098)3.41059174
33erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.39511664
34L-phenylalanine metabolic process (GO:0006558)3.39511664
35kynurenine metabolic process (GO:0070189)3.39149323
36regulation of fever generation (GO:0031620)3.36141727
37triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.34157744
38complement activation, alternative pathway (GO:0006957)3.33380365
39aromatic amino acid family catabolic process (GO:0009074)3.32412716
40nitrogen cycle metabolic process (GO:0071941)3.31603672
41regulation of fibrinolysis (GO:0051917)3.30259117
42COPI coating of Golgi vesicle (GO:0048205)3.29369769
43Golgi transport vesicle coating (GO:0048200)3.29369769
44positive regulation of fatty acid beta-oxidation (GO:0032000)3.28971921
45regulation of complement activation (GO:0030449)3.28864787
46cellular response to thyroid hormone stimulus (GO:0097067)3.28246843
47epoxygenase P450 pathway (GO:0019373)3.27061471
48positive regulation of chemokine biosynthetic process (GO:0045080)3.24971308
49positive regulation of heat generation (GO:0031652)3.23604084
50positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.22770468
51serine family amino acid metabolic process (GO:0009069)3.21261156
52hypotonic response (GO:0006971)3.20429689
53glycolipid catabolic process (GO:0019377)3.19847793
54negative regulation of cholesterol transport (GO:0032375)3.17297316
55negative regulation of sterol transport (GO:0032372)3.17297316
56regulation of fatty acid beta-oxidation (GO:0031998)3.13783751
57tryptophan catabolic process (GO:0006569)3.13364393
58indole-containing compound catabolic process (GO:0042436)3.13364393
59indolalkylamine catabolic process (GO:0046218)3.13364393
60negative regulation of fatty acid biosynthetic process (GO:0045717)3.08318430
61folic acid-containing compound biosynthetic process (GO:0009396)3.07836583
62tryptophan metabolic process (GO:0006568)3.06271012
63regulation of vascular endothelial growth factor production (GO:0010574)3.05400045
64mitotic sister chromatid cohesion (GO:0007064)3.02547175
65apoptotic cell clearance (GO:0043277)2.99577691
66glyoxylate metabolic process (GO:0046487)2.97517593
67bile acid biosynthetic process (GO:0006699)2.96790403
68serine family amino acid biosynthetic process (GO:0009070)2.94510256
69pore complex assembly (GO:0046931)2.93009669
70wound healing, spreading of epidermal cells (GO:0035313)2.92815677
71high-density lipoprotein particle remodeling (GO:0034375)2.91673642
72phospholipid homeostasis (GO:0055091)2.90280339
73positive regulation vascular endothelial growth factor production (GO:0010575)2.90274147
74positive regulation of extracellular matrix organization (GO:1903055)2.89871081
75one-carbon metabolic process (GO:0006730)2.89460587
76regulation of early endosome to late endosome transport (GO:2000641)2.87807641
77low-density lipoprotein particle clearance (GO:0034383)2.86161304
78negative regulation of lipid storage (GO:0010888)2.85343807
79positive regulation of endothelial cell apoptotic process (GO:2000353)2.84858940
80endodermal cell differentiation (GO:0035987)2.84122591
81osteoclast differentiation (GO:0030316)2.83534175
82fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.83501057
83retina vasculature morphogenesis in camera-type eye (GO:0061299)2.83305379
84regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.82145363
85dicarboxylic acid biosynthetic process (GO:0043650)2.82136979
86regulation of chemokine biosynthetic process (GO:0045073)2.82080645
87amino-acid betaine metabolic process (GO:0006577)2.80913289
88epithelial cell-cell adhesion (GO:0090136)2.80521198
89response to laminar fluid shear stress (GO:0034616)2.79950162
90valine metabolic process (GO:0006573)2.78275660
91negative regulation of lipid transport (GO:0032369)2.77589901
92folic acid metabolic process (GO:0046655)2.77335753
93decidualization (GO:0046697)2.77314181
94cell adhesion mediated by integrin (GO:0033627)2.75209019
95regulation of RNA export from nucleus (GO:0046831)2.75175608
96response to thyroid hormone (GO:0097066)2.75131976
97substrate-dependent cell migration (GO:0006929)2.74143243
98bile acid metabolic process (GO:0008206)2.74124809
99plasma lipoprotein particle clearance (GO:0034381)2.73471672
100regulation of podosome assembly (GO:0071801)2.73284376
101regulation of triglyceride catabolic process (GO:0010896)2.72003669
102pinocytosis (GO:0006907)2.70078960
103regulation of macrophage chemotaxis (GO:0010758)2.69256603
1042-oxoglutarate metabolic process (GO:0006103)2.68776572
105regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.68690362
106positive regulation of lipid catabolic process (GO:0050996)2.68460869
107cellular response to ethanol (GO:0071361)2.68072596
108growth hormone receptor signaling pathway (GO:0060396)2.67892406
109cytoplasmic mRNA processing body assembly (GO:0033962)2.67379865
110embryonic process involved in female pregnancy (GO:0060136)2.67365656
111regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.66804441
112bile acid and bile salt transport (GO:0015721)2.66400564
113reverse cholesterol transport (GO:0043691)2.65581484
114tetrahydrofolate metabolic process (GO:0046653)2.65550624
115hyaluronan catabolic process (GO:0030214)2.65535839
116regulation of cholesterol storage (GO:0010885)2.65320053
117NLS-bearing protein import into nucleus (GO:0006607)2.64805345
118triglyceride homeostasis (GO:0070328)2.64517788
119acylglycerol homeostasis (GO:0055090)2.64517788
120ceramide catabolic process (GO:0046514)2.64514530
121protein-lipid complex assembly (GO:0065005)2.64282108
122positive regulation of nitric oxide biosynthetic process (GO:0045429)2.63061834
123regulation of translational termination (GO:0006449)2.62988561
124regulation of integrin activation (GO:0033623)2.62195149
125cellular response to arsenic-containing substance (GO:0071243)2.62075910
126epithelial cell differentiation involved in prostate gland development (GO:0060742)2.60604907
127ethanol oxidation (GO:0006069)2.60566105
128stress fiber assembly (GO:0043149)2.60300990
129positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.59958883
130fibrinolysis (GO:0042730)2.58402958
131positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.57922741
132negative regulation of protein localization to plasma membrane (GO:1903077)2.57169141
133regulation of transforming growth factor beta1 production (GO:0032908)2.56507348
134plasma lipoprotein particle assembly (GO:0034377)2.56437178
135lipoprotein metabolic process (GO:0042157)2.55465398
1364-hydroxyproline metabolic process (GO:0019471)2.54911203
137regulation of nitric oxide biosynthetic process (GO:0045428)2.53515621
138negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.51629355
139negative regulation of fatty acid transport (GO:2000192)2.49388337
140detection of molecule of bacterial origin (GO:0032490)2.48541549
141sterol homeostasis (GO:0055092)2.48331600
142mRNA transcription (GO:0009299)2.48162843
143cellular glucuronidation (GO:0052695)2.47916970
144dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.47832088
145negative regulation of anoikis (GO:2000811)2.47740006
146tyrosine metabolic process (GO:0006570)2.47691543
147fatty acid transmembrane transport (GO:1902001)2.46197900
148regulation of translational fidelity (GO:0006450)2.46067855
149COPII vesicle coating (GO:0048208)2.45996548
150membrane lipid catabolic process (GO:0046466)2.45227451
151alpha-amino acid catabolic process (GO:1901606)2.45153199
152regulation of spindle organization (GO:0090224)2.45146021
153mammary gland epithelial cell proliferation (GO:0033598)2.44647033
154embryonic retina morphogenesis in camera-type eye (GO:0060059)2.44635732
155positive regulation of histone deacetylation (GO:0031065)2.44487091
156iron ion import (GO:0097286)2.44174284
157monoubiquitinated protein deubiquitination (GO:0035520)2.44085010
158glutamate metabolic process (GO:0006536)2.43869394
159cholesterol homeostasis (GO:0042632)2.43360705
160barbed-end actin filament capping (GO:0051016)2.42660371
161protein localization to kinetochore (GO:0034501)2.42165139
162sphingosine metabolic process (GO:0006670)2.41387568
163plasma lipoprotein particle remodeling (GO:0034369)2.41280790
164protein-lipid complex remodeling (GO:0034368)2.41280790
165macromolecular complex remodeling (GO:0034367)2.41280790
166mesodermal cell differentiation (GO:0048333)2.41271108
167aromatic amino acid family metabolic process (GO:0009072)2.41118083
168urate metabolic process (GO:0046415)2.40668702
169cellular response to lipopolysaccharide (GO:0071222)2.40212801
170organ regeneration (GO:0031100)2.40193124
171monocyte chemotaxis (GO:0002548)2.39775865
172regulation of cytokine secretion involved in immune response (GO:0002739)2.38421871
173membrane protein ectodomain proteolysis (GO:0006509)2.38244217
174hemidesmosome assembly (GO:0031581)2.37904418
175positive regulation of leukocyte degranulation (GO:0043302)2.37707936
176cell-substrate junction assembly (GO:0007044)2.36667542
177cortical actin cytoskeleton organization (GO:0030866)2.34539511
178negative regulation of alcohol biosynthetic process (GO:1902931)2.33053368
179eosinophil chemotaxis (GO:0048245)2.32600974
180positive regulation of interleukin-6 production (GO:0032755)2.31270903
181response to vitamin D (GO:0033280)2.30655927
182regulation of heterotypic cell-cell adhesion (GO:0034114)2.30336769
183chronic inflammatory response (GO:0002544)2.29103264
184negative regulation of nitric oxide biosynthetic process (GO:0045019)2.29081824
185membrane raft organization (GO:0031579)2.28689660
186germinal center formation (GO:0002467)2.28601837
187hyaluronan metabolic process (GO:0030212)2.27917578
188glial cell migration (GO:0008347)2.26738296
189cellular response to molecule of bacterial origin (GO:0071219)2.25367901
190regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.25268366
191wound healing, spreading of cells (GO:0044319)2.24594461
192response to lipoprotein particle (GO:0055094)2.21327414
193positive regulation of cellular amide metabolic process (GO:0034250)2.17803856
194positive regulation of leukocyte chemotaxis (GO:0002690)2.17126875

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.42438875
2E2F7_22180533_ChIP-Seq_HELA_Human5.32051517
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.94869978
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.73501529
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.70475369
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.67862926
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.60406632
8* LXR_22158963_ChIP-Seq_LIVER_Mouse3.27962016
9SMAD_19615063_ChIP-ChIP_OVARY_Human3.09727096
10CLOCK_20551151_ChIP-Seq_293T_Human2.75742559
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.70873761
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.59292141
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.59234394
14AR_21909140_ChIP-Seq_LNCAP_Human2.42839663
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.42150880
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.39012691
17* IRF8_27001747_Chip-Seq_BMDM_Mouse2.31661786
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.27439758
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.09041037
20ZNF263_19887448_ChIP-Seq_K562_Human2.07737460
21MYC_22102868_ChIP-Seq_BL_Human2.01678764
22WT1_19549856_ChIP-ChIP_CCG9911_Human1.95400899
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.93119317
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85977366
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.80932217
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.80916356
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.79952796
28* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75751638
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68277464
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.65261331
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.65131509
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.63153276
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63074723
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58203313
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56372282
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52449983
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51645377
38NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.49767127
39SALL4_18804426_ChIP-ChIP_XEN_Mouse1.49693993
40FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.47103970
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.46865947
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.43103606
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42016796
44GATA6_25053715_ChIP-Seq_YYC3_Human1.41982325
45TFEB_21752829_ChIP-Seq_HELA_Human1.41955411
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41856218
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41818857
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.40835798
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40676898
50CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39889153
51VDR_24787735_ChIP-Seq_THP-1_Human1.39603606
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.39406091
53ATF3_27146783_Chip-Seq_COLON_Human1.38944600
54GATA1_22025678_ChIP-Seq_K562_Human1.37536695
55* PU_27001747_Chip-Seq_BMDM_Mouse1.37367646
56* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37221064
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37169139
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36961049
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34483600
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34265875
61CJUN_26792858_Chip-Seq_BT549_Human1.34108386
62ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33729029
63FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31828494
64TCF7_22412390_ChIP-Seq_EML_Mouse1.31066807
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29789641
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29392232
67* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28945139
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.28843858
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28512328
70JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28163354
71* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27721050
72SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27539266
73* FOXA2_19822575_ChIP-Seq_HepG2_Human1.26905701
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.26364995
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25243634
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25243634
77CHD1_26751641_Chip-Seq_LNCaP_Human1.24237834
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.23831448
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22347990
80JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20976271
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20832090
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19795416
83SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19795416
84TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.18693606
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17612112
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16333127
87NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15876416
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15860319
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15522362
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14808295
91GATA4_25053715_ChIP-Seq_YYC3_Human1.14438202
92SOX2_20726797_ChIP-Seq_SW620_Human1.13854066
93* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12533741
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12240216
95ESR2_21235772_ChIP-Seq_MCF-7_Human1.11558765
96STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09168640
97* TBX20_22328084_ChIP-Seq_HEART_Mouse1.09089334
98* TBX20_22080862_ChIP-Seq_HEART_Mouse1.09089334
99BRD4_25478319_ChIP-Seq_HGPS_Human1.08000627
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07368310
101BP1_19119308_ChIP-ChIP_Hs578T_Human1.06931076
102* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06136238
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05742580
104* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03046003
105ELK3_25401928_ChIP-Seq_HUVEC_Human1.01485514
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01098417
107NCOR1_26117541_ChIP-Seq_K562_Human1.01090354
108SPI1_23127762_ChIP-Seq_K562_Human1.00707414
109* HNF4A_19822575_ChIP-Seq_HepG2_Human1.00001422
110UBF1/2_26484160_Chip-Seq_HMECs_Human0.98060575
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97871080
112MYB_26560356_Chip-Seq_TH1_Human0.97826974
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97091397
114SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96659460
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96470823
116TP53_16413492_ChIP-PET_HCT116_Human0.95026609
117GATA1_19941826_ChIP-Seq_K562_Human0.94803001
118* KDM2B_26808549_Chip-Seq_DND41_Human0.94631626
119* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94539131
120KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94281620
121VDR_24763502_ChIP-Seq_THP-1_Human0.94067251
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92495586
123KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92198302
124FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91574645
125KDM5A_27292631_Chip-Seq_BREAST_Human0.91564676
126MAF_26560356_Chip-Seq_TH1_Human0.91251433
127RACK7_27058665_Chip-Seq_MCF-7_Human0.91063149
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88454112
129UTX_26944678_Chip-Seq_JUKART_Human0.87594038
130ESR1_20079471_ChIP-ChIP_T-47D_Human0.87433399
131NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87185365
132EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86253676
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86132384
134ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85287331
135* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85004845
136* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84626995
137* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83776121
138NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83391155
139TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82762443

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.63443392
2MP0005360_urolithiasis4.01853491
3MP0003705_abnormal_hypodermis_morpholog3.61969995
4MP0005365_abnormal_bile_salt3.40373220
5MP0005085_abnormal_gallbladder_physiolo3.29870984
6MP0010352_gastrointestinal_tract_polyps2.83327495
7MP0003252_abnormal_bile_duct2.82269944
8MP0010234_abnormal_vibrissa_follicle2.42121509
9MP0003300_gastrointestinal_ulcer2.39793084
10MP0005451_abnormal_body_composition2.37916955
11MP0005058_abnormal_lysosome_morphology2.37601278
12MP0008875_abnormal_xenobiotic_pharmacok2.36548345
13MP0005076_abnormal_cell_differentiation2.10659315
14MP0003950_abnormal_plasma_membrane2.07341631
15MP0004510_myositis2.07163920
16MP0010329_abnormal_lipoprotein_level1.99766487
17MP0009840_abnormal_foam_cell1.91993425
18MP0000343_altered_response_to1.87252521
19MP0002254_reproductive_system_inflammat1.86263392
20MP0003806_abnormal_nucleotide_metabolis1.83829673
21MP0005257_abnormal_intraocular_pressure1.77995720
22MP0006082_CNS_inflammation1.76656403
23MP0010307_abnormal_tumor_latency1.75729604
24MP0008438_abnormal_cutaneous_collagen1.74397178
25MP0003566_abnormal_cell_adhesion1.73228824
26MP0003448_altered_tumor_morphology1.67568367
27MP0002998_abnormal_bone_remodeling1.65475299
28MP0000609_abnormal_liver_physiology1.65377308
29MP0002138_abnormal_hepatobiliary_system1.63646760
30MP0003191_abnormal_cellular_cholesterol1.61048132
31MP0001666_abnormal_nutrient_absorption1.61032148
32MP0008004_abnormal_stomach_pH1.60765052
33MP0002148_abnormal_hypersensitivity_rea1.56982155
34MP0005083_abnormal_biliary_tract1.54301372
35MP0004233_abnormal_muscle_weight1.51860531
36MP0002877_abnormal_melanocyte_morpholog1.50190610
37MP0000858_altered_metastatic_potential1.49030512
38MP0003941_abnormal_skin_development1.48376528
39MP0000604_amyloidosis1.44889961
40MP0009053_abnormal_anal_canal1.42672046
41MP0003172_abnormal_lysosome_physiology1.41460939
42MP0004185_abnormal_adipocyte_glucose1.39449359
43MP0002166_altered_tumor_susceptibility1.38361027
44MP0005164_abnormal_response_to1.35892230
45MP0002419_abnormal_innate_immunity1.35460543
46MP0005023_abnormal_wound_healing1.33924818
47MP0009785_altered_susceptibility_to1.33139731
48MP0003075_altered_response_to1.30774431
49MP0003279_aneurysm1.30563412
50MP0003828_pulmonary_edema1.30004219
51MP0004264_abnormal_extraembryonic_tissu1.29417825
52MP0000733_abnormal_muscle_development1.26210696
53MP0005332_abnormal_amino_acid1.24644344
54MP0003868_abnormal_feces_composition1.24143084
55MP0009764_decreased_sensitivity_to1.20974908
56MP0001533_abnormal_skeleton_physiology1.19275169
57MP0001853_heart_inflammation1.19171198
58MP0001730_embryonic_growth_arrest1.18649945
59MP0009384_cardiac_valve_regurgitation1.18550228
60MP0002086_abnormal_extraembryonic_tissu1.18403267
61MP0004197_abnormal_fetal_growth/weight/1.15181292
62MP0001915_intracranial_hemorrhage1.09649099
63MP0002118_abnormal_lipid_homeostasis1.09427500
64MP0002088_abnormal_embryonic_growth/wei1.08231552
65MP0000598_abnormal_liver_morphology1.08142888
66MP0003984_embryonic_growth_retardation1.07876630
67MP0005275_abnormal_skin_tensile1.07116100
68MP0005623_abnormal_meninges_morphology1.06402816
69MP0005666_abnormal_adipose_tissue1.05596664
70MP0005319_abnormal_enzyme/_coenzyme1.05541372
71MP0003453_abnormal_keratinocyte_physiol1.04759589
72MP0003693_abnormal_embryo_hatching1.04539937
73MP0005000_abnormal_immune_tolerance1.04408968
74MP0005380_embryogenesis_phenotype1.04310408
75MP0001672_abnormal_embryogenesis/_devel1.04310408
76MP0002332_abnormal_exercise_endurance1.04143090
77MP0003091_abnormal_cell_migration1.04080647
78MP0006054_spinal_hemorrhage1.03489441
79MP0000371_diluted_coat_color1.02808863
80MP0004957_abnormal_blastocyst_morpholog1.00650781
81MP0002006_tumorigenesis0.99839184
82MP0008057_abnormal_DNA_replication0.98833424
83MP0005397_hematopoietic_system_phenotyp0.97647796
84MP0001545_abnormal_hematopoietic_system0.97647796
85MP0003690_abnormal_glial_cell0.97220766
86MP0003111_abnormal_nucleus_morphology0.97134033
87MP0002060_abnormal_skin_morphology0.96704261
88MP0001216_abnormal_epidermal_layer0.95843064
89MP0003221_abnormal_cardiomyocyte_apopto0.95128131
90MP0005166_decreased_susceptibility_to0.94923742
91MP0001881_abnormal_mammary_gland0.94837606
92MP0000350_abnormal_cell_proliferation0.93516677
93MP0009672_abnormal_birth_weight0.93253090
94MP0003303_peritoneal_inflammation0.93194238
95MP0003724_increased_susceptibility_to0.92632481
96MP0010678_abnormal_skin_adnexa0.92356438
97MP0001835_abnormal_antigen_presentation0.92280637
98MP0004019_abnormal_vitamin_homeostasis0.91419295
99MP0005220_abnormal_exocrine_pancreas0.91365759
100MP0001849_ear_inflammation0.90738094
101MP0001958_emphysema0.90147479
102MP0004272_abnormal_basement_membrane0.89973421
103MP0005165_increased_susceptibility_to0.89482827
104MP0004808_abnormal_hematopoietic_stem0.89327516
105MP0000627_abnormal_mammary_gland0.87386765
106MP0002396_abnormal_hematopoietic_system0.87125445
107MP0004947_skin_inflammation0.87117071
108MP0005464_abnormal_platelet_physiology0.86776122
109MP0001790_abnormal_immune_system0.85776807
110MP0005387_immune_system_phenotype0.85776807
111MP0004130_abnormal_muscle_cell0.84007756
112MP0005248_abnormal_Harderian_gland0.82505102
113MP0003077_abnormal_cell_cycle0.82491787
114MP0010155_abnormal_intestine_physiology0.82369212
115MP0002405_respiratory_system_inflammati0.82336977
116MP0002928_abnormal_bile_duct0.81753131
117MP0001845_abnormal_inflammatory_respons0.81750751
118MP0000537_abnormal_urethra_morphology0.81326157
119MP0002452_abnormal_antigen_presenting0.81260924
120MP0005167_abnormal_blood-brain_barrier0.80907171
121MP0005408_hypopigmentation0.80456993
122MP0009643_abnormal_urine_homeostasis0.80288232
123MP0005025_abnormal_response_to0.78761766
124MP0005310_abnormal_salivary_gland0.78282195
125MP0002084_abnormal_developmental_patter0.78158095
126MP0001697_abnormal_embryo_size0.78026856
127MP0003656_abnormal_erythrocyte_physiolo0.77139846
128MP0005621_abnormal_cell_physiology0.76911578
129MP0009278_abnormal_bone_marrow0.76477598
130MP0005375_adipose_tissue_phenotype0.76146074
131MP0008469_abnormal_protein_level0.75855569
132MP0000383_abnormal_hair_follicle0.75255532
133MP0010094_abnormal_chromosome_stability0.74464959
134MP0003795_abnormal_bone_structure0.74266581
135MP0004084_abnormal_cardiac_muscle0.72736391
136MP0002971_abnormal_brown_adipose0.72724745
137MP0009703_decreased_birth_body0.71719067
138MP0005197_abnormal_uvea_morphology0.71444527
139MP0003567_abnormal_fetal_cardiomyocyte0.70450330
140MP0003329_amyloid_beta_deposits0.70347437
141MP0002796_impaired_skin_barrier0.70032428
142MP0003115_abnormal_respiratory_system0.69154853
143MP0002168_other_aberrant_phenotype0.68906218
144MP0002080_prenatal_lethality0.68712298
145MP0000249_abnormal_blood_vessel0.68120113
146MP0001661_extended_life_span0.68095499
147MP0001727_abnormal_embryo_implantation0.68092673
148MP0003890_abnormal_embryonic-extraembry0.67617057
149MP0005647_abnormal_sex_gland0.67315408
150MP0003045_fibrosis0.67107753
151MP0003436_decreased_susceptibility_to0.66421041
152MP0000685_abnormal_immune_system0.66182968
153MP0000767_abnormal_smooth_muscle0.65783763
154MP0009763_increased_sensitivity_to0.65753695
155MP0008961_abnormal_basal_metabolism0.65242958
156MP0002092_abnormal_eye_morphology0.65092267
157MP0003195_calcinosis0.64973173
158MP0000569_abnormal_digit_pigmentation0.64734225
159MP0001243_abnormal_dermal_layer0.64726567
160MP0002896_abnormal_bone_mineralization0.63993197

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.87991830
2Abnormality of liposaccharide metabolism (HP:0010968)4.87991830
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.87991830
4Deep venous thrombosis (HP:0002625)4.66682061
5Intrahepatic cholestasis (HP:0001406)4.03223208
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.89862328
7Xanthomatosis (HP:0000991)3.58381939
8Myocardial infarction (HP:0001658)3.45647959
9Hypobetalipoproteinemia (HP:0003563)3.21676504
10Vacuolated lymphocytes (HP:0001922)3.05275481
11Abnormality of the common coagulation pathway (HP:0010990)2.98682295
12Complement deficiency (HP:0004431)2.97584146
13Spondylolisthesis (HP:0003302)2.92013509
14Dysostosis multiplex (HP:0000943)2.89319431
15Vertebral compression fractures (HP:0002953)2.85442122
16Epidermoid cyst (HP:0200040)2.84538456
17Osteolytic defects of the hand bones (HP:0009699)2.74374932
18Osteolytic defects of the phalanges of the hand (HP:0009771)2.74374932
19Spastic diplegia (HP:0001264)2.73657033
20Hypolipoproteinemia (HP:0010981)2.72992416
21Increased cerebral lipofuscin (HP:0011813)2.69132983
22Esophageal varix (HP:0002040)2.68763075
23Tetraparesis (HP:0002273)2.68427665
24Abnormality of sulfur amino acid metabolism (HP:0004339)2.67220017
25Neurofibrillary tangles (HP:0002185)2.66375057
26Hypoalphalipoproteinemia (HP:0003233)2.64734398
27Arterial tortuosity (HP:0005116)2.61107638
28Loss of speech (HP:0002371)2.59133135
29Abnormality of glutamine family amino acid metabolism (HP:0010902)2.57984586
30Cerebral aneurysm (HP:0004944)2.56593654
31Abnormality of aromatic amino acid family metabolism (HP:0004338)2.56016413
32Urinary glycosaminoglycan excretion (HP:0003541)2.53867103
33Mucopolysacchariduria (HP:0008155)2.53867103
34Hyperglycinemia (HP:0002154)2.53103685
35Increased mean platelet volume (HP:0011877)2.51346992
36Thin bony cortex (HP:0002753)2.49889151
37Subacute progressive viral hepatitis (HP:0006572)2.47485136
38Short nail (HP:0001799)2.46645946
39Spinal cord lesions (HP:0100561)2.46189956
40Syringomyelia (HP:0003396)2.46189956
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.46149577
42Cerebral inclusion bodies (HP:0100314)2.46009406
43Hyperlipoproteinemia (HP:0010980)2.44508054
44Hepatocellular carcinoma (HP:0001402)2.43944094
45Prolonged partial thromboplastin time (HP:0003645)2.42242476
46Abnormality of macrophages (HP:0004311)2.41033431
47Protrusio acetabuli (HP:0003179)2.40626388
48Abnormality of polysaccharide metabolism (HP:0011012)2.40545337
49Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40545337
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40545337
51Vascular tortuosity (HP:0004948)2.40428029
52Premature rupture of membranes (HP:0001788)2.40195981
53Abnormality of the intrinsic pathway (HP:0010989)2.37849915
54Disinhibition (HP:0000734)2.32672495
55Abnormality of complement system (HP:0005339)2.32544814
56Atrophic scars (HP:0001075)2.28675853
57Mitral valve prolapse (HP:0001634)2.27004058
58Abnormal platelet volume (HP:0011876)2.24573601
59Hyperglycinuria (HP:0003108)2.22676505
60Nuclear cataract (HP:0100018)2.20497772
61Back pain (HP:0003418)2.20341383
62Ankyloglossia (HP:0010296)2.19199967
63Shallow orbits (HP:0000586)2.15957855
64Aortic aneurysm (HP:0004942)2.15216550
65Abnormality of serine family amino acid metabolism (HP:0010894)2.14220074
66Abnormality of glycine metabolism (HP:0010895)2.14220074
67Abnormal cartilage morphology (HP:0002763)2.12987458
68Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.12175582
69Peritonitis (HP:0002586)2.11483067
70Flat acetabular roof (HP:0003180)2.11297098
71Hypoglycemic coma (HP:0001325)2.10856856
72Joint hemorrhage (HP:0005261)2.10728140
73Aneurysm (HP:0002617)2.10285233
74Fat malabsorption (HP:0002630)2.09431459
75Asymmetric septal hypertrophy (HP:0001670)2.08697811
76Absent frontal sinuses (HP:0002688)2.08543513
77Hyperammonemia (HP:0001987)2.08327961
78Insidious onset (HP:0003587)2.08305778
79Termporal pattern (HP:0011008)2.08305778
80Abnormality of oral frenula (HP:0000190)2.06882102
81Ankle contracture (HP:0006466)2.06446146
82Hypochromic microcytic anemia (HP:0004840)2.04332441
83Wormian bones (HP:0002645)2.02943190
84Ulnar bowing (HP:0003031)2.01874377
85Increased density of long bones (HP:0006392)2.00340802
86Bone pain (HP:0002653)2.00062872
87Abnormality of pyrimidine metabolism (HP:0004353)1.99158611
88Abnormality of the vasculature of the conjunctiva (HP:0008054)1.98460134
89Pseudobulbar signs (HP:0002200)1.97706495
90Hypercholesterolemia (HP:0003124)1.97420078
91Blue sclerae (HP:0000592)1.96006864
92Biliary tract neoplasm (HP:0100574)1.94110884
93Abnormality of the Achilles tendon (HP:0005109)1.93771799
94Eczematoid dermatitis (HP:0000976)1.93508531
95Natal tooth (HP:0000695)1.93105496
96Upper motor neuron abnormality (HP:0002127)1.92771379
97Hematochezia (HP:0002573)1.92044239
98Relative macrocephaly (HP:0004482)1.91848929
99Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91309940
100Increased connective tissue (HP:0009025)1.90979557
101Acanthocytosis (HP:0001927)1.90414453
102Cortical dysplasia (HP:0002539)1.89347906
103Abnormality of nucleobase metabolism (HP:0010932)1.87256867
104Apathy (HP:0000741)1.87238704
105Thoracolumbar scoliosis (HP:0002944)1.86527065
106Autoimmune thrombocytopenia (HP:0001973)1.85827811
107Abnormality of methionine metabolism (HP:0010901)1.85814109
108Gout (HP:0001997)1.84904967
109Abnormality of the distal phalanges of the toes (HP:0010182)1.84464771
110Hyperglycemia (HP:0003074)1.83695840
111Increased neuronal autofluorescent lipopigment (HP:0002074)1.81728117
112Abnormality of purine metabolism (HP:0004352)1.81305996
113Mitral stenosis (HP:0001718)1.80622535
114Rectal prolapse (HP:0002035)1.80504279
115Fragile skin (HP:0001030)1.79797732
116Enlarged penis (HP:0000040)1.79364441
117Skin nodule (HP:0200036)1.78104798
118Cervical subluxation (HP:0003308)1.77022665
119Coarse hair (HP:0002208)1.76067978
120Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.75399881
121Elbow flexion contracture (HP:0002987)1.74898576
122Metaphyseal irregularity (HP:0003025)1.74834801
123Distal lower limb amyotrophy (HP:0008944)1.74737219
124Diminished motivation (HP:0000745)1.74339601
125Cardiovascular calcification (HP:0011915)1.74070340
126Femoral bowing (HP:0002980)1.73666585
127Dilatation of the ascending aorta (HP:0005111)1.73619931
128Hydroxyprolinuria (HP:0003080)1.71351604
129Abnormality of proline metabolism (HP:0010907)1.71351604
130Overgrowth (HP:0001548)1.71212138
131Asymmetry of the thorax (HP:0001555)1.70837748
132Thick nail (HP:0001805)1.70133732
133Pathologic fracture (HP:0002756)1.67817935
134Ovoid vertebral bodies (HP:0003300)1.66573463
135Mitral regurgitation (HP:0001653)1.66246537
136Deviation of the thumb (HP:0009603)1.65848412
137Hyperacusis (HP:0010780)1.65773935
138Recurrent bacterial skin infections (HP:0005406)1.65219872
139Genu recurvatum (HP:0002816)1.63993030
140Abnormality of the acetabulum (HP:0003170)1.63975635
141Macroorchidism (HP:0000053)1.62643721
142Bilateral sensorineural hearing impairment (HP:0008619)1.62444450
143Lymphangioma (HP:0100764)1.62244653
144Persistence of primary teeth (HP:0006335)1.61863431
145Abnormality of the lumbar spine (HP:0100712)1.61724677
146Spinal rigidity (HP:0003306)1.61685345
147Heterotopia (HP:0002282)1.61585074
148Deep philtrum (HP:0002002)1.61295343
149Conjunctival telangiectasia (HP:0000524)1.61129897
150Recurrent gram-negative bacterial infections (HP:0005420)1.60864785
151Polycythemia (HP:0001901)1.60214061
152Alopecia of scalp (HP:0002293)1.59898918
153Abnormality of the fingertips (HP:0001211)1.59798882
154Long toe (HP:0010511)1.59797615
155Achilles tendon contracture (HP:0001771)1.58701845
156Abnormal foot bone ossification (HP:0010675)1.58613353
157Gingival bleeding (HP:0000225)1.58259109
158Aortic dissection (HP:0002647)1.58039137
159Menorrhagia (HP:0000132)1.57778582
160Vascular calcification (HP:0004934)1.57343548
161Abnormal delivery (HP:0001787)1.57305659
162Focal segmental glomerulosclerosis (HP:0000097)1.56830196
163Follicular hyperkeratosis (HP:0007502)1.55972683
164Axonal loss (HP:0003447)1.55455175
165Abnormal biliary tract morphology (HP:0012440)1.55215727
166Right ventricular cardiomyopathy (HP:0011663)1.54757768
167Hemorrhage of the eye (HP:0011885)1.54640049
168Vertebral clefting (HP:0008428)1.53996102
169Spontaneous abortion (HP:0005268)1.53377058
170Ketosis (HP:0001946)1.53244012
171Abnormality of the calcaneus (HP:0008364)1.52605320
172Abnormality of transition element cation homeostasis (HP:0011030)1.52369693
173Interstitial pulmonary disease (HP:0006530)1.50464890
174Global brain atrophy (HP:0002283)1.49316845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK36.11749445
2LATS13.84250388
3TRIB33.46134434
4PKN23.36810165
5MAP3K142.94921388
6CDK122.92642015
7EEF2K2.63447284
8FRK2.39204794
9SIK12.29650810
10EPHA22.26938803
11STK242.16485600
12MAP3K102.13982794
13PRPF4B2.05869114
14STK32.02637141
15CDK62.01977509
16FGFR41.95489385
17TTN1.85365386
18NME21.82722076
19PTK61.81236685
20SCYL21.78560438
21CAMK1D1.77756395
22STK101.76143379
23ERN11.75709554
24PDGFRA1.63701516
25GRK71.60665424
26NEK21.60537333
27TAOK21.58477265
28BMPR21.56303301
29ICK1.50850796
30RIPK11.50211667
31MAP3K131.48511197
32NEK91.45004312
33TAOK31.43745744
34MST1R1.41692983
35MOS1.38964410
36FLT31.36719673
37CDC71.36570042
38MTOR1.32458259
39FGFR31.31172848
40CDK41.31040831
41FGFR21.30338606
42LRRK21.30056147
43CDC42BPA1.30023995
44LATS21.21998994
45RPS6KB21.19225580
46PDGFRB1.15149422
47MATK1.13601024
48ERBB41.12249101
49CAMK1G1.12121532
50RPS6KA41.03170108
51MAP3K81.02895532
52BMX1.02198917
53NEK11.02187408
54TBK11.01726543
55FGR1.01681768
56PAK21.00366053
57ALK0.98384071
58MAP2K30.96861461
59STK38L0.95719644
60ABL20.93819953
61DDR20.93436228
62MET0.91777062
63MAP3K90.90211624
64MAP3K30.89969230
65MELK0.86688254
66CLK10.84921766
67TTK0.84544000
68PTK20.84100977
69KSR20.83694410
70FGFR10.83282771
71JAK10.82186919
72TRPM70.79470668
73KSR10.78252684
74PAK40.78025538
75JAK20.77515729
76NUAK10.76845356
77JAK30.76114436
78EPHB10.74964094
79PIM10.74909322
80BRSK20.74320416
81MAP3K70.73261217
82MAP3K10.72544548
83SMG10.72450623
84MYLK0.70856775
85STK40.69873960
86EIF2AK30.69587208
87AKT30.69082847
88IRAK40.67930949
89AURKB0.66866075
90IRAK20.66294378
91RET0.66249821
92PIM20.64490664
93MAPK110.62982162
94PDK20.62208802
95ZAP700.61133156
96CHEK10.60332459
97TYK20.60224327
98MAP3K20.60104942
99CHUK0.59693173
100WEE10.59340759
101CDK90.57068771
102ARAF0.56815716
103TGFBR20.55139707
104IKBKB0.54988041
105DMPK0.54940929
106BRD40.54307568
107GSK3A0.53367484
108MAP3K50.51796034
109WNK10.51686381
110CSK0.51374722
111IRAK10.49981681
112NTRK10.49345699
113RPS6KA20.48902891
114MAP4K10.47939888
115SGK30.47602215
116ATM0.47481508
117BCKDK0.46236474
118EGFR0.45760986
119BLK0.44800742
120ABL10.43702308
121CSNK1D0.42826746
122MAP3K60.42240385
123PRKAA20.40987559
124PBK0.40907418
125IKBKE0.40859484
126PRKAA10.40672370
127AKT20.40546472
128PDPK10.39462066
129ITK0.38379712
130MAP2K10.37761467
131CDK70.37564515
132PLK30.37535818
133ACVR1B0.37532544
134CDK20.37380570
135PIK3CG0.37197720
136TAOK10.36942320
137DYRK1B0.36642806
138ATR0.36104769
139GRK60.34743810
140FER0.34429455
141RPS6KL10.33130865
142RPS6KC10.33130865
143TYRO30.32740116

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.80159786
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.06540777
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.75378844
4Other glycan degradation_Homo sapiens_hsa005112.63101280
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.52422188
6Arginine biosynthesis_Homo sapiens_hsa002202.48485226
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.41470101
8Complement and coagulation cascades_Homo sapiens_hsa046102.17565600
9Malaria_Homo sapiens_hsa051442.12459179
10TNF signaling pathway_Homo sapiens_hsa046682.11157731
11Lysosome_Homo sapiens_hsa041422.07848283
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.06862268
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.04178657
14Selenocompound metabolism_Homo sapiens_hsa004502.01482189
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.95015906
16Fatty acid degradation_Homo sapiens_hsa000711.94862045
17Tryptophan metabolism_Homo sapiens_hsa003801.93211222
18Legionellosis_Homo sapiens_hsa051341.90157790
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.82740547
20Osteoclast differentiation_Homo sapiens_hsa043801.79022127
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77551088
22Caffeine metabolism_Homo sapiens_hsa002321.76337779
23One carbon pool by folate_Homo sapiens_hsa006701.76050095
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.75675175
25Lysine degradation_Homo sapiens_hsa003101.75545470
26Salmonella infection_Homo sapiens_hsa051321.68099315
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.66454009
28Rheumatoid arthritis_Homo sapiens_hsa053231.65050709
29Prion diseases_Homo sapiens_hsa050201.64456170
30PPAR signaling pathway_Homo sapiens_hsa033201.59772893
31Pertussis_Homo sapiens_hsa051331.58887048
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.47884009
33Leishmaniasis_Homo sapiens_hsa051401.46980307
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45885426
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45145479
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41252080
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.35617812
38Fatty acid metabolism_Homo sapiens_hsa012121.34028550
39Shigellosis_Homo sapiens_hsa051311.32401368
40Staphylococcus aureus infection_Homo sapiens_hsa051501.29107799
41Influenza A_Homo sapiens_hsa051641.28055230
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25618702
43Small cell lung cancer_Homo sapiens_hsa052221.25197832
44Tuberculosis_Homo sapiens_hsa051521.24029377
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23593713
46Bile secretion_Homo sapiens_hsa049761.23036278
47Renal cell carcinoma_Homo sapiens_hsa052111.22384304
48Biosynthesis of amino acids_Homo sapiens_hsa012301.19837182
49Vitamin B6 metabolism_Homo sapiens_hsa007501.18267589
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16387014
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14053861
52Hepatitis C_Homo sapiens_hsa051601.13339998
53Fatty acid biosynthesis_Homo sapiens_hsa000611.11970068
54Chemical carcinogenesis_Homo sapiens_hsa052041.09764539
55Propanoate metabolism_Homo sapiens_hsa006401.06283115
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05493437
57Sphingolipid metabolism_Homo sapiens_hsa006001.05190307
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.05073512
59Phagosome_Homo sapiens_hsa041451.04277208
60Adherens junction_Homo sapiens_hsa045201.03529794
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02520945
62Chronic myeloid leukemia_Homo sapiens_hsa052201.01875117
63African trypanosomiasis_Homo sapiens_hsa051431.01429486
64beta-Alanine metabolism_Homo sapiens_hsa004101.01382508
65Starch and sucrose metabolism_Homo sapiens_hsa005001.00445413
66Butanoate metabolism_Homo sapiens_hsa006501.00282345
67Measles_Homo sapiens_hsa051620.99768370
68Peroxisome_Homo sapiens_hsa041460.99733769
69Carbon metabolism_Homo sapiens_hsa012000.98429948
70B cell receptor signaling pathway_Homo sapiens_hsa046620.97584378
71Apoptosis_Homo sapiens_hsa042100.94971204
72MicroRNAs in cancer_Homo sapiens_hsa052060.93294906
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.92961235
74Insulin resistance_Homo sapiens_hsa049310.92238060
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90625672
76ABC transporters_Homo sapiens_hsa020100.90543067
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.90506768
78mTOR signaling pathway_Homo sapiens_hsa041500.88811215
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87921733
80Pentose phosphate pathway_Homo sapiens_hsa000300.87521381
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87043327
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.86880896
83Fat digestion and absorption_Homo sapiens_hsa049750.86179880
84Histidine metabolism_Homo sapiens_hsa003400.86018599
85VEGF signaling pathway_Homo sapiens_hsa043700.86000195
86Retinol metabolism_Homo sapiens_hsa008300.84530799
87ECM-receptor interaction_Homo sapiens_hsa045120.82503736
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.82156468
89Proteoglycans in cancer_Homo sapiens_hsa052050.80688221
90HIF-1 signaling pathway_Homo sapiens_hsa040660.80495025
91Bladder cancer_Homo sapiens_hsa052190.78619651
92Focal adhesion_Homo sapiens_hsa045100.76602636
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.74719812
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74093202
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73987716
96Hematopoietic cell lineage_Homo sapiens_hsa046400.73964025
97p53 signaling pathway_Homo sapiens_hsa041150.73201834
98Chemokine signaling pathway_Homo sapiens_hsa040620.73042063
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.72923768
100Phenylalanine metabolism_Homo sapiens_hsa003600.71515232
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70852702
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70604822
103Herpes simplex infection_Homo sapiens_hsa051680.69557361
104Amoebiasis_Homo sapiens_hsa051460.69544932
105Vitamin digestion and absorption_Homo sapiens_hsa049770.67989672
106ErbB signaling pathway_Homo sapiens_hsa040120.67751354
107Prostate cancer_Homo sapiens_hsa052150.67747779
108Pancreatic cancer_Homo sapiens_hsa052120.67334262
109Pyruvate metabolism_Homo sapiens_hsa006200.66484769
110Sulfur metabolism_Homo sapiens_hsa009200.65804736
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.65144287
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63940364
113AMPK signaling pathway_Homo sapiens_hsa041520.63527262
114Vibrio cholerae infection_Homo sapiens_hsa051100.62216052
115Glioma_Homo sapiens_hsa052140.61705697
116Galactose metabolism_Homo sapiens_hsa000520.60137446
117Thyroid cancer_Homo sapiens_hsa052160.59541604
118Glycerolipid metabolism_Homo sapiens_hsa005610.59107316
119FoxO signaling pathway_Homo sapiens_hsa040680.58878938
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56923665
121Tyrosine metabolism_Homo sapiens_hsa003500.56885696
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56276559
123Pathways in cancer_Homo sapiens_hsa052000.56089017
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55665188
125Melanoma_Homo sapiens_hsa052180.54155614
126Non-small cell lung cancer_Homo sapiens_hsa052230.54100676
127Viral carcinogenesis_Homo sapiens_hsa052030.53927588
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53844810
129Endometrial cancer_Homo sapiens_hsa052130.53549344
130Type II diabetes mellitus_Homo sapiens_hsa049300.52181902
131TGF-beta signaling pathway_Homo sapiens_hsa043500.51866227
132Toxoplasmosis_Homo sapiens_hsa051450.51436969
133Cell cycle_Homo sapiens_hsa041100.50707683
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50573182
135Folate biosynthesis_Homo sapiens_hsa007900.50377391
136Acute myeloid leukemia_Homo sapiens_hsa052210.50073480
137HTLV-I infection_Homo sapiens_hsa051660.50059927
138RNA transport_Homo sapiens_hsa030130.50011525
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49335716
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.48346107
141Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47606114
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47186692
143Dilated cardiomyopathy_Homo sapiens_hsa054140.46799704
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.46254409
145PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45930159
146T cell receptor signaling pathway_Homo sapiens_hsa046600.45836742
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44186014
148Dorso-ventral axis formation_Homo sapiens_hsa043200.43099465
149Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42690589
150Sulfur relay system_Homo sapiens_hsa041220.42649850
151Insulin signaling pathway_Homo sapiens_hsa049100.42648513
152AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41971188
153Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39644714
154Systemic lupus erythematosus_Homo sapiens_hsa053220.39435240
155Antigen processing and presentation_Homo sapiens_hsa046120.38759775
156Viral myocarditis_Homo sapiens_hsa054160.37767765
157Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37707282
158Hepatitis B_Homo sapiens_hsa051610.36341092
159Renin-angiotensin system_Homo sapiens_hsa046140.36063532
160Prolactin signaling pathway_Homo sapiens_hsa049170.34228111
161Arginine and proline metabolism_Homo sapiens_hsa003300.33487506
162Hippo signaling pathway_Homo sapiens_hsa043900.33221611

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