ATP13A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular potassium ion homeostasis (GO:0030007)7.27069903
2surfactant homeostasis (GO:0043129)7.06845998
3sodium ion export (GO:0071436)6.70827241
4alanine transport (GO:0032328)6.58822025
5thyroid hormone generation (GO:0006590)6.48073994
6L-amino acid import (GO:0043092)6.43161783
7amino acid import (GO:0043090)6.27145622
8chemical homeostasis within a tissue (GO:0048875)6.08226841
9cellular sodium ion homeostasis (GO:0006883)5.98086841
10gamma-aminobutyric acid transport (GO:0015812)5.93717456
11L-serine transport (GO:0015825)5.42686661
12potassium ion import (GO:0010107)5.35298778
13thyroid hormone metabolic process (GO:0042403)5.33140240
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.29008189
15C4-dicarboxylate transport (GO:0015740)5.09144183
16neurotransmitter uptake (GO:0001504)4.97482087
17cell communication by electrical coupling (GO:0010644)4.97222084
18regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.88521106
19potassium ion homeostasis (GO:0055075)4.74039957
20serine transport (GO:0032329)4.71346911
21one-carbon compound transport (GO:0019755)4.68472147
22negative regulation of cytosolic calcium ion concentration (GO:0051481)4.48070575
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.47966407
24axon ensheathment in central nervous system (GO:0032291)4.46477934
25central nervous system myelination (GO:0022010)4.46477934
26cellular response to cholesterol (GO:0071397)4.22334881
27G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.14047835
28low-density lipoprotein particle remodeling (GO:0034374)4.10675071
29negative regulation of astrocyte differentiation (GO:0048712)4.06985303
30regulation of cardiac muscle cell contraction (GO:0086004)4.02589950
31negative regulation of sodium ion transport (GO:0010766)3.97468678
32negative regulation of complement activation (GO:0045916)3.93901074
33regulation of respiratory system process (GO:0044065)3.90873830
34positive regulation of p38MAPK cascade (GO:1900745)3.83912716
35nephron tubule formation (GO:0072079)3.82711970
36ovulation cycle (GO:0042698)3.79002854
37cellular response to sterol (GO:0036315)3.63635219
38negative regulation of synaptic transmission, GABAergic (GO:0032229)3.61038517
39sodium ion homeostasis (GO:0055078)3.59956583
40glutamate receptor signaling pathway (GO:0007215)3.56287492
41locomotory exploration behavior (GO:0035641)3.54329043
42positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.49957116
43acidic amino acid transport (GO:0015800)3.46473891
44negative regulation of protein activation cascade (GO:2000258)3.46435903
45cerebellar granule cell differentiation (GO:0021707)3.45245992
46ionotropic glutamate receptor signaling pathway (GO:0035235)3.44049463
47hyperosmotic salinity response (GO:0042538)3.38009017
48regulation of phospholipid biosynthetic process (GO:0071071)3.36056970
49thyroid gland development (GO:0030878)3.35845710
50regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.35644574
51membrane assembly (GO:0071709)3.34273112
52negative regulation of humoral immune response (GO:0002921)3.32746552
53cellular response to nitric oxide (GO:0071732)3.30566926
54regulation of cilium movement (GO:0003352)3.28966046
55proline transport (GO:0015824)3.25563826
56negative regulation of protein localization to cell surface (GO:2000009)3.25527324
57cellular response to reactive nitrogen species (GO:1902170)3.20678297
58regulation of p38MAPK cascade (GO:1900744)3.19709488
59multicellular organismal water homeostasis (GO:0050891)3.19168768
60regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.16595225
61positive regulation of triglyceride biosynthetic process (GO:0010867)3.16218500
62relaxation of cardiac muscle (GO:0055119)3.14006792
63regulation of respiratory gaseous exchange (GO:0043576)3.13410447
64response to auditory stimulus (GO:0010996)3.10127056
65presynaptic membrane assembly (GO:0097105)3.05462594
66drinking behavior (GO:0042756)3.05255801
67regulation of actin filament-based movement (GO:1903115)3.00918282
68mechanosensory behavior (GO:0007638)2.99880762
69regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.98173603
70regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.97376631
71oligodendrocyte differentiation (GO:0048709)2.97012877
72neurotransmitter-gated ion channel clustering (GO:0072578)2.96992849
73adenine nucleotide transport (GO:0051503)2.96692760
74L-glutamate transport (GO:0015813)2.95703436
75regulation of activation of Janus kinase activity (GO:0010533)2.95592093
76postsynaptic membrane organization (GO:0001941)2.94489288
77G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.93898855
78synaptic transmission, glutamatergic (GO:0035249)2.93493056
79renal absorption (GO:0070293)2.91204967
80regulation of integrin-mediated signaling pathway (GO:2001044)2.90816391
81neuron cell-cell adhesion (GO:0007158)2.90564374
82tonic smooth muscle contraction (GO:0014820)2.89785667
83atrial cardiac muscle cell action potential (GO:0086014)2.88633501
84negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.88329471
85cilium or flagellum-dependent cell motility (GO:0001539)2.87310711
86regulation of astrocyte differentiation (GO:0048710)2.87043980
87regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.86913044
88negative regulation of tissue remodeling (GO:0034104)2.86639397
89appendage development (GO:0048736)2.83681038
90limb development (GO:0060173)2.83681038
91regulation of heat generation (GO:0031650)2.83559783
92positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.82817183
93negative regulation of smoothened signaling pathway (GO:0045879)2.81105847
94astrocyte differentiation (GO:0048708)2.80594082
95cellular response to leptin stimulus (GO:0044320)2.80585507
96chondroitin sulfate catabolic process (GO:0030207)2.79528208
97positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.79430666
98regulation of alkaline phosphatase activity (GO:0010692)2.78124964
99nonmotile primary cilium assembly (GO:0035058)2.75634798
100detection of temperature stimulus (GO:0016048)2.75361655
101metanephric nephron tubule development (GO:0072234)2.75281297
102metanephric tubule development (GO:0072170)2.75281297
103vascular smooth muscle contraction (GO:0014829)2.75205326
104positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.73054898
105regulation of short-term neuronal synaptic plasticity (GO:0048172)2.71804215
106L-amino acid transport (GO:0015807)2.71539547
107neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.71074430
108auditory behavior (GO:0031223)2.70027426
109presynaptic membrane organization (GO:0097090)2.68739982
110establishment of skin barrier (GO:0061436)2.67402357
111cilium movement (GO:0003341)2.65701261
112peripheral nervous system axon ensheathment (GO:0032292)2.64429823
113myelination in peripheral nervous system (GO:0022011)2.64429823
114neuronal action potential propagation (GO:0019227)2.63025840
115water homeostasis (GO:0030104)2.62219019
116positive regulation of potassium ion transmembrane transport (GO:1901381)2.61126550
117Golgi to plasma membrane protein transport (GO:0043001)2.60824928
118positive regulation of phosphatase activity (GO:0010922)2.60497726
119neuromuscular junction development (GO:0007528)2.60334539
120phosphate ion transmembrane transport (GO:0035435)2.60268288
121regulation of long-term neuronal synaptic plasticity (GO:0048169)2.59820280
122regulation of protein glycosylation (GO:0060049)2.58588515
123cell communication involved in cardiac conduction (GO:0086065)2.56530528
124peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.55598378
125purine nucleotide transport (GO:0015865)2.55280980
126negative regulation of neurotransmitter transport (GO:0051589)2.53934019
127response to cholesterol (GO:0070723)2.52990095
128metanephric nephron epithelium development (GO:0072243)2.52829170
129positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.52181609
130protein heterotetramerization (GO:0051290)2.52130997
131renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.51206631
132neutral amino acid transport (GO:0015804)2.51094671
133brain morphogenesis (GO:0048854)2.50835579
134dendrite morphogenesis (GO:0048813)2.50350298
135cell morphogenesis involved in neuron differentiation (GO:0048667)2.50091504
136long-term memory (GO:0007616)2.49473268
137vocalization behavior (GO:0071625)2.49218211
138regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.49075645
139regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.48251966
140regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.46811488
141lipid translocation (GO:0034204)2.44965910
142phospholipid translocation (GO:0045332)2.44965910
143very-low-density lipoprotein particle assembly (GO:0034379)2.44029014
144response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.44010171
145artery smooth muscle contraction (GO:0014824)2.43261990
146regulation of water loss via skin (GO:0033561)2.42909160
147epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.42769353
148phosphate ion transport (GO:0006817)2.41836172
149regulation of membrane repolarization (GO:0060306)2.41498321
150cGMP-mediated signaling (GO:0019934)2.41332993
151hair follicle development (GO:0001942)2.40918253
152positive regulation of cellular amide metabolic process (GO:0034250)2.40449279
153dicarboxylic acid biosynthetic process (GO:0043650)2.40295081
154fatty acid elongation (GO:0030497)2.40198636
155regulation of beta-amyloid formation (GO:1902003)2.39879434
156response to leptin (GO:0044321)2.39867289
157plasma lipoprotein particle organization (GO:0071827)2.39621685
158negative regulation of heart contraction (GO:0045822)2.39565076
159negative regulation of muscle contraction (GO:0045932)2.39067837
160glycine transport (GO:0015816)2.39016553
161positive regulation of sodium ion transmembrane transport (GO:1902307)2.38205729
162response to histamine (GO:0034776)2.38016018
163negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.37580081
164negative regulation of glial cell differentiation (GO:0045686)2.37536438
165establishment of nucleus localization (GO:0040023)2.36809658
166photoreceptor cell differentiation (GO:0046530)2.35083881
167eye photoreceptor cell differentiation (GO:0001754)2.35083881
168regulation of complement activation (GO:0030449)2.33014158
169regulation of endothelial cell chemotaxis (GO:2001026)2.31328041
170astrocyte development (GO:0014002)2.31034678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.38553473
2EZH2_22144423_ChIP-Seq_EOC_Human3.04741176
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79468002
4AR_21572438_ChIP-Seq_LNCaP_Human2.74111005
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.64484369
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.51774709
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47457481
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35919145
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.32911437
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.23838322
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19497706
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18113475
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18113475
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14859923
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.10348599
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.10270888
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09228181
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08040503
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01247018
20DROSHA_22980978_ChIP-Seq_HELA_Human1.97130993
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94019090
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.93672990
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92654580
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.91432380
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.90131088
26FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.84714323
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79206597
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77986293
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73216875
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.71865787
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.70152129
32REST_21632747_ChIP-Seq_MESCs_Mouse1.64808637
33RXR_22108803_ChIP-Seq_LS180_Human1.58323273
34GATA1_22025678_ChIP-Seq_K562_Human1.57930860
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57672349
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56334460
37* P300_19829295_ChIP-Seq_ESCs_Human1.52238523
38SMAD4_21799915_ChIP-Seq_A2780_Human1.49343873
39TP53_16413492_ChIP-PET_HCT116_Human1.48807071
40BCAT_22108803_ChIP-Seq_LS180_Human1.47657569
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47571357
42* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47057990
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45402400
44FOXM1_26456572_ChIP-Seq_MCF-7_Human1.45142330
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44486885
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43629873
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.43370051
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41874521
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41515978
50TP53_18474530_ChIP-ChIP_U2OS_Human1.40946833
51CJUN_26792858_Chip-Seq_BT549_Human1.39175348
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39089612
53* AR_25329375_ChIP-Seq_VCAP_Human1.36751357
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36133231
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.34110344
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33157572
57CDX2_20551321_ChIP-Seq_CACO-2_Human1.32291655
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29688973
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.29149881
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.23513685
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23011733
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.22591818
63PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22004351
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.20250758
65TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19861227
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19086380
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.18243492
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17146263
69AHR_22903824_ChIP-Seq_MCF-7_Human1.16966711
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16809655
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16755306
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16418042
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16230064
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16019111
75AR_19668381_ChIP-Seq_PC3_Human1.13805531
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.13639374
77* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12471580
78ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12128466
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11544420
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11414267
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11414267
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11078946
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11010399
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10536723
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10467568
86* STAT3_23295773_ChIP-Seq_U87_Human1.10422164
87RUNX2_22187159_ChIP-Seq_PCA_Human1.09187336
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.08705604
89TCF4_22108803_ChIP-Seq_LS180_Human1.08136024
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07603483
91TP63_23658742_ChIP-Seq_EP156T_Human1.07438701
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06447876
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.05786498
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.03850137
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03678282
96TRIM28_21343339_ChIP-Seq_HEK293_Human1.03113371
97REST_18959480_ChIP-ChIP_MESCs_Mouse1.03079904
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03069425
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02915350
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02850368
101ESR2_21235772_ChIP-Seq_MCF-7_Human1.02741846
102* TCF4_23295773_ChIP-Seq_U87_Human1.02224882
103STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.01998594
104WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01339614
105SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00804706
106SMAD3_21741376_ChIP-Seq_HESCs_Human0.98827371
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98472825
108NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98472825
109RARB_27405468_Chip-Seq_BRAIN_Mouse0.98094402
110PRDM14_20953172_ChIP-Seq_ESCs_Human0.98030330
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97717444
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.97401300
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96860862
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95887815
115TAF15_26573619_Chip-Seq_HEK293_Human0.95878590
116YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95771207
117CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94795573
118NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93886700
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93849590
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91941576
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91066790
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90107022
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90070635
124POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89759132
125EP300_21415370_ChIP-Seq_HL-1_Mouse0.88801762
126EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88040743

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.89863960
2MP0004782_abnormal_surfactant_physiolog4.43233120
3MP0005423_abnormal_somatic_nervous4.36561418
4MP0004885_abnormal_endolymph4.25539942
5MP0004270_analgesia3.67363604
6MP0000383_abnormal_hair_follicle3.51731924
7MP0001984_abnormal_olfaction3.24297459
8MP0010368_abnormal_lymphatic_system3.22777160
9MP0003878_abnormal_ear_physiology3.14348057
10MP0005377_hearing/vestibular/ear_phenot3.14348057
11MP0002254_reproductive_system_inflammat3.14340694
12MP0004858_abnormal_nervous_system3.13621693
13MP0003690_abnormal_glial_cell3.12266502
14MP0005171_absent_coat_pigmentation3.00720206
15MP0010678_abnormal_skin_adnexa2.96244810
16MP0009046_muscle_twitch2.94764392
17MP0000681_abnormal_thyroid_gland2.74789614
18MP0004859_abnormal_synaptic_plasticity2.73732046
19MP0000566_synostosis2.63924658
20MP0001486_abnormal_startle_reflex2.54632391
21MP0009384_cardiac_valve_regurgitation2.48059943
22MP0009780_abnormal_chondrocyte_physiolo2.44732972
23MP0001485_abnormal_pinna_reflex2.31849356
24MP0003635_abnormal_synaptic_transmissio2.29683464
25MP0001440_abnormal_grooming_behavior2.27157399
26MP0005388_respiratory_system_phenotype2.05936465
27MP0002133_abnormal_respiratory_system2.05936465
28MP0002876_abnormal_thyroid_physiology1.99550389
29MP0002064_seizures1.97633690
30MP0009745_abnormal_behavioral_response1.90508648
31MP0002572_abnormal_emotion/affect_behav1.89326533
32MP0008004_abnormal_stomach_pH1.81561202
33MP0002653_abnormal_ependyma_morphology1.78970136
34MP0003633_abnormal_nervous_system1.78914820
35MP0001502_abnormal_circadian_rhythm1.75957016
36MP0002063_abnormal_learning/memory/cond1.73055452
37MP0005023_abnormal_wound_healing1.71281443
38MP0008995_early_reproductive_senescence1.68438219
39MP0001501_abnormal_sleep_pattern1.63165346
40MP0002272_abnormal_nervous_system1.62849777
41MP0002734_abnormal_mechanical_nocicepti1.61742512
42MP0001851_eye_inflammation1.57213043
43MP0003329_amyloid_beta_deposits1.55578417
44MP0001968_abnormal_touch/_nociception1.55507427
45MP0003634_abnormal_glial_cell1.54455421
46MP0002089_abnormal_postnatal_growth/wei1.52895421
47MP0004742_abnormal_vestibular_system1.51598246
48MP0002067_abnormal_sensory_capabilities1.49934073
49MP0002736_abnormal_nociception_after1.47796708
50MP0008569_lethality_at_weaning1.44122140
51MP0003879_abnormal_hair_cell1.43392787
52MP0005167_abnormal_blood-brain_barrier1.43238658
53MP0004043_abnormal_pH_regulation1.41519894
54MP0003880_abnormal_central_pattern1.40812302
55MP0003631_nervous_system_phenotype1.40249938
56MP0005646_abnormal_pituitary_gland1.40019030
57MP0004142_abnormal_muscle_tone1.38695952
58MP0005275_abnormal_skin_tensile1.35689582
59MP0003566_abnormal_cell_adhesion1.33033779
60MP0006292_abnormal_olfactory_placode1.26294511
61MP0000465_gastrointestinal_hemorrhage1.25950788
62MP0002557_abnormal_social/conspecific_i1.25394058
63MP0002098_abnormal_vibrissa_morphology1.20979959
64MP0003091_abnormal_cell_migration1.18442888
65MP0003075_altered_response_to1.17241048
66MP0001879_abnormal_lymphatic_vessel1.17175228
67MP0000579_abnormal_nail_morphology1.14573438
68MP0003950_abnormal_plasma_membrane1.11346642
69MP0005551_abnormal_eye_electrophysiolog1.10876638
70MP0000778_abnormal_nervous_system1.10456258
71MP0002909_abnormal_adrenal_gland1.10278181
72MP0003115_abnormal_respiratory_system1.08026968
73MP0004215_abnormal_myocardial_fiber1.07745545
74MP0000604_amyloidosis1.07719228
75MP0002638_abnormal_pupillary_reflex1.07586429
76MP0000920_abnormal_myelination1.06729910
77MP0001958_emphysema1.06135397
78MP0002733_abnormal_thermal_nociception1.05960601
79MP0001963_abnormal_hearing_physiology1.05758231
80MP0003183_abnormal_peptide_metabolism1.04261227
81MP0001853_heart_inflammation1.04196117
82MP0000049_abnormal_middle_ear1.04024478
83MP0003632_abnormal_nervous_system1.03267144
84MP0001299_abnormal_eye_distance/1.01682255
85MP0005386_behavior/neurological_phenoty0.98317671
86MP0004924_abnormal_behavior0.98317671
87MP0002822_catalepsy0.98209507
88MP0002295_abnormal_pulmonary_circulatio0.98202591
89MP0002168_other_aberrant_phenotype0.97141660
90MP0005409_darkened_coat_color0.96602655
91MP0001970_abnormal_pain_threshold0.96364153
92MP0006138_congestive_heart_failure0.95916845
93MP0003137_abnormal_impulse_conducting0.95270803
94MP0000026_abnormal_inner_ear0.94033722
95MP0000377_abnormal_hair_follicle0.93734785
96MP0002882_abnormal_neuron_morphology0.93147918
97MP0003453_abnormal_keratinocyte_physiol0.92273424
98MP0005165_increased_susceptibility_to0.89616524
99MP0005595_abnormal_vascular_smooth0.88691101
100MP0002229_neurodegeneration0.85831611
101MP0005164_abnormal_response_to0.85570836
102MP0004272_abnormal_basement_membrane0.83809487
103MP0003191_abnormal_cellular_cholesterol0.83242195
104MP0002066_abnormal_motor_capabilities/c0.82991097
105MP0004484_altered_response_of0.82436165
106MP0000427_abnormal_hair_cycle0.81717442
107MP0000955_abnormal_spinal_cord0.81629417
108MP0002249_abnormal_larynx_morphology0.81133055
109MP0002152_abnormal_brain_morphology0.80567915
110MP0002796_impaired_skin_barrier0.80547007
111MP0004084_abnormal_cardiac_muscle0.80265923
112MP0005253_abnormal_eye_physiology0.80070611
113MP0003045_fibrosis0.80040004
114MP0001177_atelectasis0.79680803
115MP0004883_abnormal_blood_vessel0.79112560
116MP0002735_abnormal_chemical_nociception0.77622823
117MP0004036_abnormal_muscle_relaxation0.77176037
118MP0003172_abnormal_lysosome_physiology0.76298046
119MP0000613_abnormal_salivary_gland0.76060910
120MP0005332_abnormal_amino_acid0.75189111
121MP0010771_integument_phenotype0.74673883
122MP0004233_abnormal_muscle_weight0.74427513
123MP0005645_abnormal_hypothalamus_physiol0.74425332
124MP0005670_abnormal_white_adipose0.72472223
125MP0001881_abnormal_mammary_gland0.72046708
126MP0002090_abnormal_vision0.71647350
127MP0001905_abnormal_dopamine_level0.71402380
128MP0003638_abnormal_response/metabolism_0.70866192
129MP0005257_abnormal_intraocular_pressure0.70189291
130MP0003646_muscle_fatigue0.69960319
131MP0010234_abnormal_vibrissa_follicle0.69811037
132MP0004134_abnormal_chest_morphology0.68700094
133MP0003938_abnormal_ear_development0.67012014
134MP0001756_abnormal_urination0.66048846
135MP0003300_gastrointestinal_ulcer0.65658656
136MP0000428_abnormal_craniofacial_morphol0.64762326
137MP0002184_abnormal_innervation0.62329499
138MP0005410_abnormal_fertilization0.60960343
139MP0003279_aneurysm0.59856986
140MP0001664_abnormal_digestion0.58841780
141MP0000631_abnormal_neuroendocrine_gland0.57735414
142MP0001986_abnormal_taste_sensitivity0.57313824
143MP0000647_abnormal_sebaceous_gland0.56366683
144MP0002752_abnormal_somatic_nervous0.54763717
145MP0003283_abnormal_digestive_organ0.54648042

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)8.90690456
2Interstitial pulmonary disease (HP:0006530)6.89223390
3Abnormality of binocular vision (HP:0011514)6.25236762
4Diplopia (HP:0000651)6.25236762
5Aplasia of the phalanges of the hand (HP:0009802)6.11245219
6Aplasia involving bones of the extremities (HP:0009825)6.11245219
7Aplasia involving bones of the upper limbs (HP:0009823)6.11245219
8Hemiparesis (HP:0001269)5.57487212
9Hemiplegia (HP:0002301)5.16050738
10Goiter (HP:0000853)5.11213502
11Confusion (HP:0001289)4.38187640
12Abnormality of secondary sexual hair (HP:0009888)4.30309798
13Abnormality of the axillary hair (HP:0100134)4.30309798
14Onycholysis (HP:0001806)3.88509797
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.70540500
16Megalencephaly (HP:0001355)3.64904351
17Facial shape deformation (HP:0011334)3.61100836
18Potter facies (HP:0002009)3.61100836
19Hypoplastic left heart (HP:0004383)3.46601998
20Pili torti (HP:0003777)3.42406626
21Hyperthyroidism (HP:0000836)3.36014244
22Atonic seizures (HP:0010819)3.31711576
23Hyperactive renin-angiotensin system (HP:0000841)3.30367760
24Focal motor seizures (HP:0011153)3.27844410
25Abnormality of nail color (HP:0100643)3.19883187
26Neonatal respiratory distress (HP:0002643)3.12231742
27Abnormal ciliary motility (HP:0012262)3.11013250
28Tetraplegia (HP:0002445)3.08003589
29Clumsiness (HP:0002312)3.01250220
30Gait imbalance (HP:0002141)3.00618514
31Abnormal respiratory motile cilium physiology (HP:0012261)2.99647631
32Hyperpituitarism (HP:0010514)2.99424068
33Rhinitis (HP:0012384)2.98038515
34Glomerulonephritis (HP:0000099)2.94233912
35Chronic bronchitis (HP:0004469)2.92618137
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.91089721
37Absent/shortened dynein arms (HP:0200106)2.91089721
38Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.88339624
39Respiratory distress (HP:0002098)2.88326254
40Short hallux (HP:0010109)2.83770133
41Abnormality of the middle phalanges of the toes (HP:0010183)2.83031588
42Congenital primary aphakia (HP:0007707)2.80370358
43Synostosis involving the elbow (HP:0003938)2.76525473
44Humeroradial synostosis (HP:0003041)2.76525473
45Renal tubular acidosis (HP:0001947)2.73375155
46Medial flaring of the eyebrow (HP:0010747)2.71826341
47Neurofibrillary tangles (HP:0002185)2.69742867
48Mixed hearing impairment (HP:0000410)2.69504123
49Cutaneous finger syndactyly (HP:0010554)2.63679070
50Hypoplastic heart (HP:0001961)2.60693240
51Tachypnea (HP:0002789)2.59065412
52Decreased circulating renin level (HP:0003351)2.58801663
53Hypoalphalipoproteinemia (HP:0003233)2.57614978
54Fibular aplasia (HP:0002990)2.56938020
55Epileptic encephalopathy (HP:0200134)2.56544378
56Generalized tonic-clonic seizures (HP:0002069)2.53161612
57Split foot (HP:0001839)2.51032661
58Aplasia/Hypoplasia of the hallux (HP:0008362)2.50486291
59Hyperaldosteronism (HP:0000859)2.48484653
60Abnormal respiratory epithelium morphology (HP:0012253)2.47259612
61Abnormal respiratory motile cilium morphology (HP:0005938)2.47259612
62Subacute progressive viral hepatitis (HP:0006572)2.46358864
63Abnormality of hair growth rate (HP:0011363)2.43403720
64Slow-growing hair (HP:0002217)2.43403720
65Vaginal atresia (HP:0000148)2.41217568
66Morphological abnormality of the inner ear (HP:0011390)2.41147812
67Adactyly (HP:0009776)2.41034595
68Genital tract atresia (HP:0001827)2.39697188
69Alveolar cell carcinoma (HP:0006519)2.39544674
70Narrow nasal bridge (HP:0000446)2.39264035
71Nephrogenic diabetes insipidus (HP:0009806)2.37991218
72Absent hair (HP:0002298)2.37454795
73Action tremor (HP:0002345)2.37128386
74Supranuclear gaze palsy (HP:0000605)2.36931920
75Focal seizures (HP:0007359)2.33423699
76Abnormality of the dental pulp (HP:0006479)2.32489463
77Nephritis (HP:0000123)2.32139318
78Laryngomalacia (HP:0001601)2.29347923
79Postural instability (HP:0002172)2.26488959
80Bronchiectasis (HP:0002110)2.26085351
81Abnormality of renin-angiotensin system (HP:0000847)2.25253087
82Abnormality of the fingertips (HP:0001211)2.23958075
83Tubulointerstitial fibrosis (HP:0005576)2.23848912
84Neoplasm of the tracheobronchial system (HP:0100552)2.23341571
85Follicular hyperkeratosis (HP:0007502)2.23318795
86Widely patent fontanelles and sutures (HP:0004492)2.22036303
87Cutaneous syndactyly (HP:0012725)2.20525707
88Abnormal hair laboratory examination (HP:0003328)2.19351210
89Long nose (HP:0003189)2.17367522
90Hypothermia (HP:0002045)2.16673683
91Hypokalemic alkalosis (HP:0001949)2.14116287
92Abnormal urine output (HP:0012590)2.13644621
93Renal salt wasting (HP:0000127)2.12158021
94Dysdiadochokinesis (HP:0002075)2.11798576
95Bronchomalacia (HP:0002780)2.11002101
96Morphological abnormality of the middle ear (HP:0008609)2.08991515
97Complement deficiency (HP:0004431)2.08607422
98Bradycardia (HP:0001662)2.08531123
99Systemic lupus erythematosus (HP:0002725)2.05201101
100Hypothyroidism (HP:0000821)2.04324428
101Absent speech (HP:0001344)2.02035706
102Ulnar claw (HP:0001178)2.01255247
103Poor coordination (HP:0002370)2.00941329
104Abnormality of renal excretion (HP:0011036)2.00063518
105Progressive cerebellar ataxia (HP:0002073)2.00027522
106Increased circulating renin level (HP:0000848)1.99045196
107Hyperkalemia (HP:0002153)1.98825810
108Hyperventilation (HP:0002883)1.98529439
109Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.95417084
110Thickened helices (HP:0000391)1.94027471
111Paraparesis (HP:0002385)1.90754390
112Neonatal short-limb short stature (HP:0008921)1.90408298
113Metabolic alkalosis (HP:0200114)1.89244193
114Asthma (HP:0002099)1.89011132
115Renal dysplasia (HP:0000110)1.88393762
116Cerebral inclusion bodies (HP:0100314)1.87711592
117Status epilepticus (HP:0002133)1.87647576
118Lower limb hyperreflexia (HP:0002395)1.87399106
119Increased CSF protein (HP:0002922)1.86152997
120Portal hypertension (HP:0001409)1.85177362
121Abnormality of the periventricular white matter (HP:0002518)1.84847405
122Tetraparesis (HP:0002273)1.84794065
123Craniofacial hyperostosis (HP:0004493)1.84375163
124Blepharitis (HP:0000498)1.84144504
125Alacrima (HP:0000522)1.84142028
126Taurodontia (HP:0000679)1.79999654
127Abnormality of permanent molar morphology (HP:0011071)1.79999654
128Abnormality of the dental root (HP:0006486)1.79999654
129Adrenal overactivity (HP:0002717)1.78876961
130Maternal diabetes (HP:0009800)1.78854521
131Aplasia/Hypoplasia of the fibula (HP:0006492)1.78361803
132Abnormality of the diencephalon (HP:0010662)1.78235940
133Neoplasm of the heart (HP:0100544)1.77980562
134Hypoplasia of the iris (HP:0007676)1.77520408
135Purpura (HP:0000979)1.77386628
136Thyroid carcinoma (HP:0002890)1.77363878
137Hypoplasia of the ulna (HP:0003022)1.76732467
138Overgrowth (HP:0001548)1.76218742
139Aplasia/Hypoplasia of the lens (HP:0008063)1.75560841
140Oligodactyly (hands) (HP:0001180)1.74844008
141Large for gestational age (HP:0001520)1.73493971
142Abnormality of molar morphology (HP:0011070)1.73051535
143Abnormality of molar (HP:0011077)1.73051535
144Hoarse voice (HP:0001609)1.72312509
145Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.71163987
146Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.70630902
147Tubulointerstitial abnormality (HP:0001969)1.70323919
148Short middle phalanx of the 5th finger (HP:0004220)1.70126435
149Broad alveolar ridges (HP:0000187)1.69830144
150Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.69376953
151Abnormal eating behavior (HP:0100738)1.68708794
152Intention tremor (HP:0002080)1.67856780
153Alopecia of scalp (HP:0002293)1.67659771
154Blue irides (HP:0000635)1.67453956
155Back pain (HP:0003418)1.66316811
156Truncal ataxia (HP:0002078)1.65857188
157Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.65420600
158Absent toe (HP:0010760)1.65027344
159Left ventricular hypertrophy (HP:0001712)1.64490565
160Symphalangism affecting the phalanges of the hand (HP:0009773)1.64468828
161Pheochromocytoma (HP:0002666)1.64345200
162Cranial hyperostosis (HP:0004437)1.64163813
163Corneal erosion (HP:0200020)1.63153258
164True hermaphroditism (HP:0010459)1.60796155
165Broad hallux (HP:0010055)1.59919559
166Abnormality of calcium-phosphate metabolism (HP:0100530)1.59718743
167Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.58507013
168Pseudobulbar signs (HP:0002200)1.57875632
169Brittle hair (HP:0002299)1.57153124
170Abnormality of the proximal phalanges of the hand (HP:0009834)1.56071328
171Abnormality of the nasal septum (HP:0000419)1.55813986
172Multifactorial inheritance (HP:0001426)1.54700425
173Hypoplastic nipples (HP:0002557)1.54437099
174Progressive sensorineural hearing impairment (HP:0000408)1.54393924
175Microglossia (HP:0000171)1.53852894

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK7.05264454
2MST1R4.57233636
3MAPK154.40380185
4PRKD33.50031798
5CASK3.11945345
6NTRK22.86427893
7EPHA22.66093266
8MET2.62642154
9PHKG22.44151809
10PHKG12.44151809
11EPHA42.32223862
12EPHA32.25979208
13INSRR2.24699966
14MUSK2.19216359
15CAMK1G2.17244655
16MST42.11374821
17FRK2.11288087
18MAPK132.07968829
19CAMK1D2.05504646
20PDK22.04950451
21SGK21.99847678
22NTRK31.93623211
23SIK11.89246129
24MKNK21.77449990
25SGK31.77175267
26LMTK21.72764353
27FER1.69964567
28SGK2231.55072298
29SGK4941.55072298
30PIK3CA1.45706995
31MAPK121.45134155
32MARK11.44252426
33MAP2K71.43043354
34MAP3K131.41580945
35MAP3K61.38594859
36PRKD21.37939465
37IRAK31.33073882
38MAP3K41.31462063
39NEK61.27373293
40STK38L1.25008060
41LRRK21.11969582
42MAP3K21.11438842
43RIPK11.10669251
44PRKAA21.09669082
45TIE11.06612422
46PRKCG1.04162187
47PRKCH0.99669102
48MAP3K70.98064353
49RET0.97612103
50RIPK40.91900142
51LATS10.91531491
52PRKCE0.91074582
53FGFR20.89619890
54EPHB10.89422771
55GRK10.88282953
56ERBB40.87610599
57PDGFRB0.87521001
58MINK10.86504862
59FES0.86306621
60TRPM70.86301067
61NLK0.85331599
62AKT30.85280769
63BMX0.80794931
64PINK10.78713658
65FGFR40.78440787
66FGR0.78221588
67TNK20.75125175
68DYRK1A0.74745936
69NTRK10.74285677
70PAK60.70651666
71CDK50.70541949
72PKN10.69783520
73CAMK2G0.69632798
74CSNK1A1L0.68135608
75SGK10.67872521
76CAMK2A0.65866505
77MAP3K30.64864987
78ROCK10.64724778
79PTK2B0.64251737
80MAPK70.63862313
81CDC42BPA0.63717578
82MAP2K40.62850053
83WNK10.62759039
84ADRBK10.62172152
85PRPF4B0.62037570
86STK380.61403722
87MAPKAPK30.59904798
88ERBB30.59515641
89FGFR30.59499440
90TYRO30.58556267
91JAK20.56838711
92CAMK10.56477168
93IGF1R0.56439317
94MARK20.55970565
95BCR0.55717358
96YES10.55140346
97FGFR10.53641184
98IRAK10.53607645
99MAP3K90.52611433
100EGFR0.51659797
101PAK30.51101763
102PRKCA0.51011083
103CSNK1G20.50280721
104PRKG10.50004087
105KSR10.48899969
106TRIB30.48209659
107TAOK30.47931069
108PRKCQ0.47252210
109CDK30.46956484
110NEK90.46945217
111AKT20.46347106
112PRKAA10.46282563
113CSNK1G10.46036533
114GSK3A0.44676728
115BMPR1B0.44505684
116STK240.44486877
117JAK10.44379228
118PRKACG0.43880345
119PRKD10.43777129
120CAMK2B0.43200432
121MAPK110.43123315
122PDPK10.42716421
123PNCK0.42468402
124PRKACA0.40308267
125RPS6KA30.40181233
126DDR20.40022916
127PDK10.39709175
128ROCK20.39460007
129PRKCZ0.38946514
130ABL10.38557918
131ERBB20.38404480
132RPS6KA20.37897082
133DAPK20.36963055
134OXSR10.36885621
135DMPK0.36339631
136SRC0.35709268
137BRSK20.35604142
138CSNK1A10.34274876
139PRKCB0.32957832
140STK390.32530842
141MAPK100.31537436
142FYN0.31120175
143RPS6KB10.30283394
144STK110.29640902

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009106.34954896
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049644.77050497
3Fatty acid biosynthesis_Homo sapiens_hsa000614.46829089
4Nicotine addiction_Homo sapiens_hsa050332.61030690
5Histidine metabolism_Homo sapiens_hsa003402.58624811
6Salivary secretion_Homo sapiens_hsa049702.01752432
7GABAergic synapse_Homo sapiens_hsa047271.89553222
8ECM-receptor interaction_Homo sapiens_hsa045121.86519314
9Gastric acid secretion_Homo sapiens_hsa049711.85002634
10Glutamatergic synapse_Homo sapiens_hsa047241.81787878
11beta-Alanine metabolism_Homo sapiens_hsa004101.78558277
12Bile secretion_Homo sapiens_hsa049761.77846097
13Fatty acid metabolism_Homo sapiens_hsa012121.72485036
14Mineral absorption_Homo sapiens_hsa049781.69468487
15Insulin secretion_Homo sapiens_hsa049111.66971160
16Dorso-ventral axis formation_Homo sapiens_hsa043201.66367436
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65690472
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50401716
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41681605
20Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.38863291
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36613892
22Morphine addiction_Homo sapiens_hsa050321.32699054
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32054733
24Circadian entrainment_Homo sapiens_hsa047131.31781121
25Pancreatic secretion_Homo sapiens_hsa049721.30470072
26Adherens junction_Homo sapiens_hsa045201.26450347
27Tight junction_Homo sapiens_hsa045301.23044205
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19745330
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19294370
30Renin secretion_Homo sapiens_hsa049241.17699123
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14828625
32Complement and coagulation cascades_Homo sapiens_hsa046101.13767522
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12440234
34Vitamin digestion and absorption_Homo sapiens_hsa049771.11073738
35Calcium signaling pathway_Homo sapiens_hsa040201.08839291
36cAMP signaling pathway_Homo sapiens_hsa040241.08645973
37Long-term potentiation_Homo sapiens_hsa047201.08170059
38PPAR signaling pathway_Homo sapiens_hsa033201.06521389
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05555956
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03774262
41Fatty acid degradation_Homo sapiens_hsa000711.01477809
42Linoleic acid metabolism_Homo sapiens_hsa005911.00342914
43Primary bile acid biosynthesis_Homo sapiens_hsa001200.99821840
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99625915
45Autoimmune thyroid disease_Homo sapiens_hsa053200.98906965
46Circadian rhythm_Homo sapiens_hsa047100.96761315
47Thyroid hormone synthesis_Homo sapiens_hsa049180.93825530
48Tryptophan metabolism_Homo sapiens_hsa003800.92113282
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90984870
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90096699
51Focal adhesion_Homo sapiens_hsa045100.89571554
52Pertussis_Homo sapiens_hsa051330.88778649
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.88604750
54Amphetamine addiction_Homo sapiens_hsa050310.87538561
55Cocaine addiction_Homo sapiens_hsa050300.87373263
56Platelet activation_Homo sapiens_hsa046110.84686806
57Notch signaling pathway_Homo sapiens_hsa043300.83531272
58Taste transduction_Homo sapiens_hsa047420.83280739
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.82233775
60Olfactory transduction_Homo sapiens_hsa047400.81915965
61Arginine biosynthesis_Homo sapiens_hsa002200.81611412
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81472102
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79505928
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.78952996
65Long-term depression_Homo sapiens_hsa047300.78407275
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78387802
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76135691
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76075581
69Basal cell carcinoma_Homo sapiens_hsa052170.74105459
70Serotonergic synapse_Homo sapiens_hsa047260.72693780
71Choline metabolism in cancer_Homo sapiens_hsa052310.72301992
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72230935
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72074742
74Staphylococcus aureus infection_Homo sapiens_hsa051500.72068811
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71456968
76Melanogenesis_Homo sapiens_hsa049160.69025647
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68860708
78Steroid biosynthesis_Homo sapiens_hsa001000.66317071
79Gap junction_Homo sapiens_hsa045400.65650225
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.65241108
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65098891
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64221294
83Glycerolipid metabolism_Homo sapiens_hsa005610.63814551
84Renin-angiotensin system_Homo sapiens_hsa046140.62801885
85Endometrial cancer_Homo sapiens_hsa052130.61414094
86Ovarian steroidogenesis_Homo sapiens_hsa049130.61201191
87Renal cell carcinoma_Homo sapiens_hsa052110.58157809
88Dilated cardiomyopathy_Homo sapiens_hsa054140.57189175
89Cardiac muscle contraction_Homo sapiens_hsa042600.56448190
90Lysosome_Homo sapiens_hsa041420.56443903
91ABC transporters_Homo sapiens_hsa020100.56365696
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55658968
93Arginine and proline metabolism_Homo sapiens_hsa003300.55191577
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53805158
95Axon guidance_Homo sapiens_hsa043600.53754180
96Cholinergic synapse_Homo sapiens_hsa047250.53653895
97Dopaminergic synapse_Homo sapiens_hsa047280.51542295
98Sphingolipid metabolism_Homo sapiens_hsa006000.50783217
99Synaptic vesicle cycle_Homo sapiens_hsa047210.49813462
100Hedgehog signaling pathway_Homo sapiens_hsa043400.49776171
101Oxytocin signaling pathway_Homo sapiens_hsa049210.49427582
102GnRH signaling pathway_Homo sapiens_hsa049120.48665085
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48276632
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47447092
105Rap1 signaling pathway_Homo sapiens_hsa040150.46464579
106Amoebiasis_Homo sapiens_hsa051460.45796087
107Arachidonic acid metabolism_Homo sapiens_hsa005900.45780273
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43419400
109Fatty acid elongation_Homo sapiens_hsa000620.41319812
110Lysine degradation_Homo sapiens_hsa003100.41059891
111ErbB signaling pathway_Homo sapiens_hsa040120.39952888
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39603713
113Melanoma_Homo sapiens_hsa052180.38849313
114Ether lipid metabolism_Homo sapiens_hsa005650.38043658
115Protein digestion and absorption_Homo sapiens_hsa049740.36918015
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35961324
117Propanoate metabolism_Homo sapiens_hsa006400.33845229
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.33696474
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33619273
120Glucagon signaling pathway_Homo sapiens_hsa049220.33075007
121Ras signaling pathway_Homo sapiens_hsa040140.33054343
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31613941
123Type II diabetes mellitus_Homo sapiens_hsa049300.30458516
124Peroxisome_Homo sapiens_hsa041460.29667955
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.29654719
126Wnt signaling pathway_Homo sapiens_hsa043100.26871236
127Inositol phosphate metabolism_Homo sapiens_hsa005620.26195474
128MAPK signaling pathway_Homo sapiens_hsa040100.25632357
129Malaria_Homo sapiens_hsa051440.23560846
130Estrogen signaling pathway_Homo sapiens_hsa049150.23475413

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