ATP13A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glucuronate metabolic process (GO:0019585)7.18849212
2uronic acid metabolic process (GO:0006063)7.18849212
3cellular glucuronidation (GO:0052695)7.09482668
4xenobiotic catabolic process (GO:0042178)6.24877731
5behavioral response to nicotine (GO:0035095)5.53581650
6regulation of cholesterol biosynthetic process (GO:0045540)5.18411119
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.72824861
8response to nitrosative stress (GO:0051409)4.69285923
9pyrimidine-containing compound transmembrane transport (GO:0072531)4.56302408
10phenylpropanoid metabolic process (GO:0009698)4.43151532
11keratinocyte development (GO:0003334)4.41567164
12potassium ion import (GO:0010107)4.32639953
13L-amino acid import (GO:0043092)4.13533447
14regulation of lipoprotein metabolic process (GO:0050746)4.03254575
15cellular ketone body metabolic process (GO:0046950)3.87475315
16positive regulation of cholesterol efflux (GO:0010875)3.87114774
17postsynaptic membrane organization (GO:0001941)3.80992212
18positive regulation of steroid biosynthetic process (GO:0010893)3.80920030
19piRNA metabolic process (GO:0034587)3.71118267
20detection of light stimulus involved in visual perception (GO:0050908)3.68407833
21detection of light stimulus involved in sensory perception (GO:0050962)3.68407833
22cellular potassium ion homeostasis (GO:0030007)3.68303589
23ovulation cycle (GO:0042698)3.67784767
24G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.67465594
25relaxation of smooth muscle (GO:0044557)3.66995952
26detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.66428300
27relaxation of muscle (GO:0090075)3.65544953
28urinary tract smooth muscle contraction (GO:0014848)3.64284044
29generation of neurons (GO:0048699)3.62076089
30regulation of cilium movement (GO:0003352)3.62045619
31hormone catabolic process (GO:0042447)3.61522596
32ethanol oxidation (GO:0006069)3.57490926
33relaxation of cardiac muscle (GO:0055119)3.55904327
34positive regulation of cholesterol transport (GO:0032376)3.43202168
35positive regulation of sterol transport (GO:0032373)3.43202168
36transmission of nerve impulse (GO:0019226)3.42341667
37negative regulation of lipase activity (GO:0060192)3.42189372
38amino acid import (GO:0043090)3.42011774
39alanine transport (GO:0032328)3.41736227
40multicellular organism reproduction (GO:0032504)3.41207434
41ketone body metabolic process (GO:1902224)3.40029732
42regulation of steroid hormone biosynthetic process (GO:0090030)3.39194303
43nucleotide transmembrane transport (GO:1901679)3.37653881
44opioid receptor signaling pathway (GO:0038003)3.36614151
45positive regulation of meiosis (GO:0045836)3.34627934
46epithelial cilium movement (GO:0003351)3.34219398
47cilium or flagellum-dependent cell motility (GO:0001539)3.33890513
48indole-containing compound catabolic process (GO:0042436)3.31910010
49indolalkylamine catabolic process (GO:0046218)3.31910010
50tryptophan catabolic process (GO:0006569)3.31910010
51negative regulation of organelle assembly (GO:1902116)3.28914940
52regulation of microtubule-based movement (GO:0060632)3.26486659
53neuron cell-cell adhesion (GO:0007158)3.26013028
54cilium movement (GO:0003341)3.22804789
55arginine catabolic process (GO:0006527)3.20990883
56glomerulus development (GO:0032835)3.20320386
57L-fucose metabolic process (GO:0042354)3.18301845
58L-fucose catabolic process (GO:0042355)3.18301845
59fucose catabolic process (GO:0019317)3.18301845
60L-serine transport (GO:0015825)3.18252232
61positive regulation of meiotic cell cycle (GO:0051446)3.18021859
62kynurenine metabolic process (GO:0070189)3.16469703
63cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.15128937
64presynaptic membrane assembly (GO:0097105)3.14860920
65organic cation transport (GO:0015695)3.14016777
66regulation of meiosis I (GO:0060631)3.11566078
67positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.11471227
68peristalsis (GO:0030432)3.10922050
69adaptation of signaling pathway (GO:0023058)3.09088952
70regulation of skeletal muscle contraction (GO:0014819)3.06183504
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.04251161
72regulation of cholesterol metabolic process (GO:0090181)3.03033981
73cellular biogenic amine catabolic process (GO:0042402)2.99223947
74amine catabolic process (GO:0009310)2.99223947
75negative regulation of astrocyte differentiation (GO:0048712)2.97666712
76water-soluble vitamin biosynthetic process (GO:0042364)2.97354113
77regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.97111134
78kidney mesenchyme development (GO:0072074)2.95364445
79cornea development in camera-type eye (GO:0061303)2.95061079
80axon ensheathment in central nervous system (GO:0032291)2.91063546
81central nervous system myelination (GO:0022010)2.91063546
82neuronal action potential propagation (GO:0019227)2.90462318
83carnitine metabolic process (GO:0009437)2.90378406
84atrial cardiac muscle cell action potential (GO:0086014)2.89697761
85regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.89591374
86indolalkylamine metabolic process (GO:0006586)2.89140494
87axoneme assembly (GO:0035082)2.87874683
88cell differentiation involved in metanephros development (GO:0072202)2.87644654
89gap junction assembly (GO:0016264)2.86010134
90protein neddylation (GO:0045116)2.85461685
91DNA methylation involved in gamete generation (GO:0043046)2.85459123
92regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.84153902
93sulfation (GO:0051923)2.84045790
94low-density lipoprotein particle remodeling (GO:0034374)2.82442784
95axonemal dynein complex assembly (GO:0070286)2.82045894
96negative regulation of heart rate (GO:0010459)2.81200446
97Notch signaling involved in heart development (GO:0061314)2.80704917
98exogenous drug catabolic process (GO:0042738)2.79802190
99presynaptic membrane organization (GO:0097090)2.76944720
100sensory perception of smell (GO:0007608)2.76478931
101nonmotile primary cilium assembly (GO:0035058)2.76035802
102one-carbon compound transport (GO:0019755)2.75550284
103positive regulation of hormone biosynthetic process (GO:0046886)2.74973439
104mechanosensory behavior (GO:0007638)2.74658042
105negative regulation of cytosolic calcium ion concentration (GO:0051481)2.74406439
106positive regulation of chemokine secretion (GO:0090197)2.74094663
107flavonoid metabolic process (GO:0009812)2.73288107
108positive regulation of alcohol biosynthetic process (GO:1902932)2.73117722
109neural tube formation (GO:0001841)2.72471871
110metanephric mesenchyme development (GO:0072075)2.72147490
111photoreceptor cell maintenance (GO:0045494)2.71613566
112positive regulation of sodium ion transmembrane transport (GO:1902307)2.71261710
113negative regulation of telomere maintenance (GO:0032205)2.70229318
114positive regulation of guanylate cyclase activity (GO:0031284)2.69943383
115positive regulation of steroid metabolic process (GO:0045940)2.69854380
116interleukin-6-mediated signaling pathway (GO:0070102)2.69671945
117C4-dicarboxylate transport (GO:0015740)2.68301734
118positive regulation of synaptic transmission, GABAergic (GO:0032230)2.68256539
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.67816021
120synaptic transmission, cholinergic (GO:0007271)2.67264858
121regulation of timing of cell differentiation (GO:0048505)2.66436575
122kidney morphogenesis (GO:0060993)2.65470073
123regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.61839407
124serine transport (GO:0032329)2.61114452
125tryptophan metabolic process (GO:0006568)2.60924898
126L-ascorbic acid metabolic process (GO:0019852)2.60770798
127antigen processing and presentation via MHC class Ib (GO:0002475)2.60010793
128endothelium development (GO:0003158)2.59169910
129layer formation in cerebral cortex (GO:0021819)2.56306444
130purinergic nucleotide receptor signaling pathway (GO:0035590)2.55761808
131neurotransmitter metabolic process (GO:0042133)2.55313504
132regulation of axon extension involved in axon guidance (GO:0048841)2.55267399
133neurotransmitter-gated ion channel clustering (GO:0072578)2.54940233
134neuronal stem cell maintenance (GO:0097150)2.53561675
135protein polyglutamylation (GO:0018095)2.52721800
136negative regulation of neurotransmitter transport (GO:0051589)2.52569182
137sulfur amino acid catabolic process (GO:0000098)2.52390185
138benzene-containing compound metabolic process (GO:0042537)2.52196661
139retinal cone cell development (GO:0046549)2.51162543
140peptidyl-tyrosine autophosphorylation (GO:0038083)2.50460366
141thrombin receptor signaling pathway (GO:0070493)2.48905423
142potassium ion homeostasis (GO:0055075)2.48875537
143import into cell (GO:0098657)2.48379682
144positive regulation of mast cell activation (GO:0033005)2.48292973
145gamma-aminobutyric acid transport (GO:0015812)2.48074151
146regulation of response to food (GO:0032095)2.46821094
147negative regulation of transcription regulatory region DNA binding (GO:2000678)2.46708128
148regulation of cholesterol efflux (GO:0010874)2.46599069
149regulation of chemokine secretion (GO:0090196)2.46232299
150negative regulation of reactive oxygen species metabolic process (GO:2000378)2.45955420
151regulation of hippo signaling (GO:0035330)2.45715703
152regulation of collateral sprouting (GO:0048670)2.44192180
153artery smooth muscle contraction (GO:0014824)2.43250569
154vocalization behavior (GO:0071625)2.43090062
155detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.42348719
156autophagic vacuole fusion (GO:0000046)2.42230417
157aggressive behavior (GO:0002118)2.41704142
158regulation of female receptivity (GO:0045924)2.41531625
159synaptic vesicle maturation (GO:0016188)2.41192515
160acrosome reaction (GO:0007340)2.40422915
161neurotransmitter biosynthetic process (GO:0042136)2.40320494
162male meiosis I (GO:0007141)2.39854030
163dopamine transport (GO:0015872)2.39411456
164lymph vessel development (GO:0001945)2.39039615
165phasic smooth muscle contraction (GO:0014821)2.38914404
166negative regulation of response to food (GO:0032096)2.38704163
167negative regulation of appetite (GO:0032099)2.38704163
168regulation of female gonad development (GO:2000194)2.38141924
169DNA deamination (GO:0045006)2.36653848
170nucleotide transport (GO:0006862)2.36565896
171ethanol metabolic process (GO:0006067)2.36506384
172drug catabolic process (GO:0042737)2.36440625
173sperm motility (GO:0030317)2.36104918
174negative regulation of smooth muscle contraction (GO:0045986)2.35980908
175glutathione derivative metabolic process (GO:1901685)2.35959916
176glutathione derivative biosynthetic process (GO:1901687)2.35959916
177cell communication by electrical coupling (GO:0010644)2.35501652
178auditory receptor cell stereocilium organization (GO:0060088)2.34555459
179indole-containing compound metabolic process (GO:0042430)2.34159988
180phosphatidylinositol acyl-chain remodeling (GO:0036149)2.33953068
181otic vesicle formation (GO:0030916)2.33797898
182negative regulation of protein localization to cell surface (GO:2000009)2.33771204
183phagocytosis, recognition (GO:0006910)2.31749710
184tonic smooth muscle contraction (GO:0014820)2.31730007
185alkaloid metabolic process (GO:0009820)2.30465566
186regulation of cardioblast proliferation (GO:0003264)2.29551870
187regulation of secondary heart field cardioblast proliferation (GO:0003266)2.29551870
188chondroitin sulfate biosynthetic process (GO:0030206)2.28728568
189negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.27864618
190sodium ion export (GO:0071436)2.27511873
191cGMP-mediated signaling (GO:0019934)2.27346416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.11553413
2GBX2_23144817_ChIP-Seq_PC3_Human3.09019757
3VDR_22108803_ChIP-Seq_LS180_Human3.02106386
4ZNF274_21170338_ChIP-Seq_K562_Hela2.97897967
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.68549644
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53982196
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.48919481
8IGF1R_20145208_ChIP-Seq_DFB_Human2.32376659
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.29903431
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.29876315
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23659349
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10006109
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10006109
14ZNF217_24962896_ChIP-Seq_MCF-7_Human2.05162191
15DROSHA_22980978_ChIP-Seq_HELA_Human2.05043223
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03698789
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.03342431
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00184185
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99001003
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98444704
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89491316
22AR_21572438_ChIP-Seq_LNCaP_Human1.86581443
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85282950
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84083373
25* ER_23166858_ChIP-Seq_MCF-7_Human1.80046323
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.73265424
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.73100957
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73100957
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.71204691
30NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.71204691
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.63835530
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.62828934
33EWS_26573619_Chip-Seq_HEK293_Human1.62589565
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61681098
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60728724
36TP53_18474530_ChIP-ChIP_U2OS_Human1.60433071
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.59145321
38TCF4_23295773_ChIP-Seq_U87_Human1.57078682
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.57032127
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53137479
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52216467
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.50906912
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.50091053
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49743396
45EZH2_22144423_ChIP-Seq_EOC_Human1.49131728
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.49051811
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49006784
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47876184
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47746673
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47436658
51RNF2_27304074_Chip-Seq_NSC_Mouse1.47416026
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.43326929
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42333813
54FUS_26573619_Chip-Seq_HEK293_Human1.42058680
55TCF4_18268006_ChIP-ChIP_LS174T_Human1.41100082
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40465984
57TAF15_26573619_Chip-Seq_HEK293_Human1.39193357
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39173752
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39020718
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37764235
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34694848
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34352234
63CBP_20019798_ChIP-Seq_JUKART_Human1.34086288
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34086288
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32702394
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32581352
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31548367
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.31457609
69* P300_19829295_ChIP-Seq_ESCs_Human1.29466707
70FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.29360068
71* SMAD4_21741376_ChIP-Seq_EPCs_Human1.28954101
72GATA1_22025678_ChIP-Seq_K562_Human1.28512465
73TCF4_22108803_ChIP-Seq_LS180_Human1.27996693
74RUNX2_22187159_ChIP-Seq_PCA_Human1.26619724
75RXR_22108803_ChIP-Seq_LS180_Human1.26550214
76AHR_22903824_ChIP-Seq_MCF-7_Human1.25815847
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25388506
78* NANOG_19829295_ChIP-Seq_ESCs_Human1.25121319
79* SOX2_19829295_ChIP-Seq_ESCs_Human1.25121319
80* SMAD4_21799915_ChIP-Seq_A2780_Human1.24579111
81WT1_19549856_ChIP-ChIP_CCG9911_Human1.24121987
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.24074612
83* SMAD3_21741376_ChIP-Seq_EPCs_Human1.23917262
84AR_25329375_ChIP-Seq_VCAP_Human1.22839688
85IRF1_19129219_ChIP-ChIP_H3396_Human1.22490611
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21472066
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.21415818
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.20772200
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19256538
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19124832
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.18493556
92* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18294414
93TP53_16413492_ChIP-PET_HCT116_Human1.17261181
94TP53_22573176_ChIP-Seq_HFKS_Human1.17078485
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16899901
96FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16290128
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15166442
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15143686
99OCT1_27270436_Chip-Seq_PROSTATE_Human1.14737081
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14619301
101* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13704661
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12664645
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.12628254
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.11922157
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09534622
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09329053
107TP53_20018659_ChIP-ChIP_R1E_Mouse1.08886325
108FOXA1_25329375_ChIP-Seq_VCAP_Human1.06644567
109FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06644567
110P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06603298
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06186165
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03679447
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03634921
114HOXB7_26014856_ChIP-Seq_BT474_Human1.02979335
115KDM2B_26808549_Chip-Seq_REH_Human1.02413069
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02054972
117PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01407651
118BCAT_22108803_ChIP-Seq_LS180_Human1.00230492
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99782814
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99738470
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98696541
122NCOR_22424771_ChIP-Seq_293T_Human0.98548375
123AR_20517297_ChIP-Seq_VCAP_Human0.97926385
124FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97810561
125CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97252755
126AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97114822
127IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97088278
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96522734
129REST_21632747_ChIP-Seq_MESCs_Mouse0.96429679
130EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94075057
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93287910
132KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92788965
133KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92788965
134KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92788965
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.92757308
136BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92755004
137LXR_22158963_ChIP-Seq_LIVER_Mouse0.92634251
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91850019
139CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91508920
140SOX2_21211035_ChIP-Seq_LN229_Gbm0.91437320
141ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90050445
142NANOG_18555785_Chip-Seq_ESCs_Mouse0.88199591
143RARB_27405468_Chip-Seq_BRAIN_Mouse0.88155064
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87993827
145GATA2_21666600_ChIP-Seq_HMVEC_Human0.87080739
146POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86602669
147NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86513122
148ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.86433971
149STAT3_23295773_ChIP-Seq_U87_Human0.86263506
150TP63_23658742_ChIP-Seq_EP156T_Human0.85974084

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005499_abnormal_olfactory_system5.97171980
2MP0005394_taste/olfaction_phenotype5.97171980
3MP0008789_abnormal_olfactory_epithelium5.10658514
4MP0001984_abnormal_olfaction5.10115986
5MP0008875_abnormal_xenobiotic_pharmacok4.72399322
6MP0003646_muscle_fatigue3.16383405
7MP0009780_abnormal_chondrocyte_physiolo3.14907657
8MP0003878_abnormal_ear_physiology2.88859789
9MP0005377_hearing/vestibular/ear_phenot2.88859789
10MP0005423_abnormal_somatic_nervous2.66048100
11MP0002736_abnormal_nociception_after2.55805109
12MP0004084_abnormal_cardiac_muscle2.49028304
13MP0008877_abnormal_DNA_methylation2.48180041
14MP0004147_increased_porphyrin_level2.38488869
15MP0002837_dystrophic_cardiac_calcinosis2.35284297
16MP0004885_abnormal_endolymph2.32357780
17MP0002733_abnormal_thermal_nociception2.22116386
18MP0009384_cardiac_valve_regurgitation2.18802072
19MP0005410_abnormal_fertilization1.94776627
20MP0003690_abnormal_glial_cell1.94486241
21MP0006276_abnormal_autonomic_nervous1.93137499
22MP0002254_reproductive_system_inflammat1.92070188
23MP0003195_calcinosis1.89595366
24MP0004130_abnormal_muscle_cell1.77610133
25MP0004859_abnormal_synaptic_plasticity1.77475378
26MP0009745_abnormal_behavioral_response1.76955480
27MP0010386_abnormal_urinary_bladder1.74357495
28MP0003718_maternal_effect1.73883497
29MP0001986_abnormal_taste_sensitivity1.72479886
30MP0000230_abnormal_systemic_arterial1.69984388
31MP0004036_abnormal_muscle_relaxation1.62875875
32MP0000427_abnormal_hair_cycle1.60142329
33MP0010030_abnormal_orbit_morphology1.59419878
34MP0000383_abnormal_hair_follicle1.54761604
35MP0002638_abnormal_pupillary_reflex1.54656898
36MP0005645_abnormal_hypothalamus_physiol1.54085795
37MP0008775_abnormal_heart_ventricle1.50759291
38MP0002009_preneoplasia1.50322397
39MP0004270_analgesia1.48665546
40MP0002233_abnormal_nose_morphology1.47937253
41MP0003136_yellow_coat_color1.47156645
42MP0003879_abnormal_hair_cell1.45300494
43MP0001501_abnormal_sleep_pattern1.41872883
44MP0002822_catalepsy1.39481160
45MP0002160_abnormal_reproductive_system1.36348280
46MP0001486_abnormal_startle_reflex1.36166655
47MP0002653_abnormal_ependyma_morphology1.36115936
48MP0004134_abnormal_chest_morphology1.35911475
49MP0003635_abnormal_synaptic_transmissio1.34561718
50MP0001905_abnormal_dopamine_level1.34140233
51MP0005167_abnormal_blood-brain_barrier1.32065719
52MP0003329_amyloid_beta_deposits1.31565766
53MP0000538_abnormal_urinary_bladder1.31186652
54MP0003633_abnormal_nervous_system1.29957949
55MP0000762_abnormal_tongue_morphology1.29868911
56MP0001485_abnormal_pinna_reflex1.29621942
57MP0002734_abnormal_mechanical_nocicepti1.29396669
58MP0000566_synostosis1.28772248
59MP0002102_abnormal_ear_morphology1.27751920
60MP0002064_seizures1.24986985
61MP0005464_abnormal_platelet_physiology1.23401598
62MP0000569_abnormal_digit_pigmentation1.23164366
63MP0002063_abnormal_learning/memory/cond1.21385327
64MP0004145_abnormal_muscle_electrophysio1.20149943
65MP0004142_abnormal_muscle_tone1.18256620
66MP0000049_abnormal_middle_ear1.16692630
67MP0010678_abnormal_skin_adnexa1.15258180
68MP0009379_abnormal_foot_pigmentation1.15159118
69MP0001664_abnormal_digestion1.14458916
70MP0002876_abnormal_thyroid_physiology1.13591586
71MP0001440_abnormal_grooming_behavior1.12949546
72MP0009840_abnormal_foam_cell1.12403299
73MP0003186_abnormal_redox_activity1.12113071
74MP0002272_abnormal_nervous_system1.11283586
75MP0001177_atelectasis1.10685465
76MP0005253_abnormal_eye_physiology1.10356598
77MP0002572_abnormal_emotion/affect_behav1.10094778
78MP0001502_abnormal_circadian_rhythm1.08272051
79MP0003880_abnormal_central_pattern1.07734296
80MP0002332_abnormal_exercise_endurance1.06058407
81MP0009250_abnormal_appendicular_skeleto1.06010008
82MP0003787_abnormal_imprinting1.05899211
83MP0005408_hypopigmentation1.04754958
84MP0003631_nervous_system_phenotype1.03297212
85MP0005620_abnormal_muscle_contractility1.03130614
86MP0002234_abnormal_pharynx_morphology1.02117405
87MP0002557_abnormal_social/conspecific_i1.00939217
88MP0000778_abnormal_nervous_system1.00729612
89MP0008004_abnormal_stomach_pH1.00155696
90MP0005389_reproductive_system_phenotype0.99950152
91MP0003045_fibrosis0.99325720
92MP0003806_abnormal_nucleotide_metabolis0.98614050
93MP0004043_abnormal_pH_regulation0.98522902
94MP0002909_abnormal_adrenal_gland0.97730193
95MP0005171_absent_coat_pigmentation0.97202625
96MP0003638_abnormal_response/metabolism_0.95536199
97MP0003279_aneurysm0.94081276
98MP0003698_abnormal_male_reproductive0.93237047
99MP0003950_abnormal_plasma_membrane0.92415105
100MP0001919_abnormal_reproductive_system0.91928703
101MP0004215_abnormal_myocardial_fiber0.91832742
102MP0001963_abnormal_hearing_physiology0.91421453
103MP0002735_abnormal_chemical_nociception0.90294506
104MP0006292_abnormal_olfactory_placode0.88938462
105MP0002752_abnormal_somatic_nervous0.86951118
106MP0008872_abnormal_physiological_respon0.82151128
107MP0001529_abnormal_vocalization0.82016819
108MP0001968_abnormal_touch/_nociception0.81697402
109MP0006072_abnormal_retinal_apoptosis0.81608511
110MP0003755_abnormal_palate_morphology0.81365603
111MP0000631_abnormal_neuroendocrine_gland0.80788531
112MP0002090_abnormal_vision0.80056614
113MP0003941_abnormal_skin_development0.79586868
114MP0004264_abnormal_extraembryonic_tissu0.79071763
115MP0005195_abnormal_posterior_eye0.78421353
116MP0004085_abnormal_heartbeat0.78317294
117MP0003075_altered_response_to0.76967185
118MP0005266_abnormal_metabolism0.76383464
119MP0005310_abnormal_salivary_gland0.75646071
120MP0009697_abnormal_copulation0.75423151
121MP0005670_abnormal_white_adipose0.75405770
122MP0001970_abnormal_pain_threshold0.75195318
123MP0008569_lethality_at_weaning0.75154746
124MP0010329_abnormal_lipoprotein_level0.75099893
125MP0004484_altered_response_of0.74809023
126MP0005365_abnormal_bile_salt0.74346196
127MP0000534_abnormal_ureter_morphology0.73808645
128MP0002067_abnormal_sensory_capabilities0.73517053
129MP0000372_irregular_coat_pigmentation0.73255584
130MP0000026_abnormal_inner_ear0.71872438
131MP0002132_abnormal_respiratory_system0.71821132
132MP0003890_abnormal_embryonic-extraembry0.71260663
133MP0005647_abnormal_sex_gland0.71023234
134MP0001929_abnormal_gametogenesis0.70874584
135MP0005551_abnormal_eye_electrophysiolog0.70721136
136MP0001879_abnormal_lymphatic_vessel0.66518540
137MP0009046_muscle_twitch0.66196331
138MP0005646_abnormal_pituitary_gland0.65806893
139MP0003937_abnormal_limbs/digits/tail_de0.64979103
140MP0001188_hyperpigmentation0.64688563
141MP0005164_abnormal_response_to0.64423101
142MP0003632_abnormal_nervous_system0.64301601
143MP0009053_abnormal_anal_canal0.63888291
144MP0004924_abnormal_behavior0.62500623
145MP0005386_behavior/neurological_phenoty0.62500623
146MP0004272_abnormal_basement_membrane0.62388719
147MP0001915_intracranial_hemorrhage0.62366166
148MP0004742_abnormal_vestibular_system0.61684088
149MP0001270_distended_abdomen0.61484181
150MP0001958_emphysema0.59775883
151MP0005595_abnormal_vascular_smooth0.58172494
152MP0003137_abnormal_impulse_conducting0.57963223
153MP0002882_abnormal_neuron_morphology0.57361710

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.68281253
2Aplasia involving bones of the upper limbs (HP:0009823)4.93259446
3Aplasia of the phalanges of the hand (HP:0009802)4.93259446
4Aplasia involving bones of the extremities (HP:0009825)4.93259446
5Synostosis involving the elbow (HP:0003938)4.62519586
6Humeroradial synostosis (HP:0003041)4.62519586
7Congenital stationary night blindness (HP:0007642)4.49826641
8Pancreatic cysts (HP:0001737)4.43721924
9True hermaphroditism (HP:0010459)4.17659947
10Abnormality of the middle phalanges of the toes (HP:0010183)4.08383844
11Osteomalacia (HP:0002749)3.98371895
12Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.96789443
13Pancreatic fibrosis (HP:0100732)3.94637088
14Type II lissencephaly (HP:0007260)3.83861432
15Flat acetabular roof (HP:0003180)3.78143009
16Onycholysis (HP:0001806)3.61463562
17Abnormality of midbrain morphology (HP:0002418)3.55644733
18Molar tooth sign on MRI (HP:0002419)3.55644733
19Abnormal tarsal ossification (HP:0008369)3.53049378
20Inability to walk (HP:0002540)3.49949286
21Vaginal fistula (HP:0004320)3.47552909
22Metaphyseal irregularity (HP:0003025)3.40054953
23Renal tubular acidosis (HP:0001947)3.39285946
24Bifid scrotum (HP:0000048)3.35778982
25Short hallux (HP:0010109)3.35356216
26Distal lower limb muscle weakness (HP:0009053)3.33502784
27Breast hypoplasia (HP:0003187)3.30582741
28Tarsal synostosis (HP:0008368)3.25843196
29Abnormality of carpal bone ossification (HP:0006257)3.24497143
30Synostosis involving bones of the lower limbs (HP:0009138)3.23030155
31Synostosis involving bones of the feet (HP:0009140)3.23030155
32Bronchomalacia (HP:0002780)3.21060381
33Decreased central vision (HP:0007663)3.19318989
34Abnormal ciliary motility (HP:0012262)3.10400359
35Fibular aplasia (HP:0002990)3.09137258
36Fragile skin (HP:0001030)3.06566790
37Nephronophthisis (HP:0000090)3.05391748
38Abnormality of the renal cortex (HP:0011035)3.05391415
39Abnormal respiratory motile cilium morphology (HP:0005938)3.02611303
40Abnormal respiratory epithelium morphology (HP:0012253)3.02611303
41Aplasia/Hypoplasia of the optic nerve (HP:0008058)3.01674067
42Aplasia/Hypoplasia of the sternum (HP:0006714)3.00996568
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.96830288
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.96830288
45Lissencephaly (HP:0001339)2.95039687
46Aplasia/Hypoplasia of the scapulae (HP:0006713)2.94596368
47Hypoplastic scapulae (HP:0000882)2.94596368
48Aplasia/Hypoplasia of the hallux (HP:0008362)2.94259316
49Absent speech (HP:0001344)2.88065395
50Split foot (HP:0001839)2.88043101
51Clumsiness (HP:0002312)2.84342728
52Cupped ribs (HP:0000887)2.81141753
53Cystic liver disease (HP:0006706)2.79345077
54Abnormality of the renal medulla (HP:0100957)2.79053929
55Attenuation of retinal blood vessels (HP:0007843)2.74315699
56Dynein arm defect of respiratory motile cilia (HP:0012255)2.71981639
57Absent/shortened dynein arms (HP:0200106)2.71981639
58Optic nerve hypoplasia (HP:0000609)2.69879823
59Abolished electroretinogram (ERG) (HP:0000550)2.69068461
60Supernumerary spleens (HP:0009799)2.68742665
61Sleep apnea (HP:0010535)2.63802839
62Diaphragmatic weakness (HP:0009113)2.63374150
63Medial flaring of the eyebrow (HP:0010747)2.62226078
64Abnormal respiratory motile cilium physiology (HP:0012261)2.62197866
65Chorioretinal atrophy (HP:0000533)2.58221300
66Turricephaly (HP:0000262)2.56844685
67Aplasia/Hypoplasia of the fovea (HP:0008060)2.55495680
68Hypoplasia of the fovea (HP:0007750)2.55495680
69Hypoplastic nipples (HP:0002557)2.55218478
70Pulmonary artery stenosis (HP:0004415)2.54640035
71Abnormal foot bone ossification (HP:0010675)2.53164454
72Absent rod-and cone-mediated responses on ERG (HP:0007688)2.52223239
73Protruding tongue (HP:0010808)2.47906669
74Male pseudohermaphroditism (HP:0000037)2.46900888
75Aplasia of the musculature (HP:0100854)2.46453652
76Myokymia (HP:0002411)2.45143476
77Short nail (HP:0001799)2.44928914
78Aplasia/Hypoplasia of the tongue (HP:0010295)2.43490413
79Congenital, generalized hypertrichosis (HP:0004540)2.43219360
80Prolonged bleeding time (HP:0003010)2.43042685
81Abnormality of binocular vision (HP:0011514)2.41670423
82Diplopia (HP:0000651)2.41670423
83Obstructive sleep apnea (HP:0002870)2.40942836
84Congenital sensorineural hearing impairment (HP:0008527)2.40676879
85Large eyes (HP:0001090)2.38962015
86Absent toe (HP:0010760)2.38527712
87Renal tubular dysfunction (HP:0000124)2.37966758
88Abnormal hand bone ossification (HP:0010660)2.37752115
89Gait imbalance (HP:0002141)2.37618388
90Abnormal biliary tract physiology (HP:0012439)2.37544567
91Bile duct proliferation (HP:0001408)2.37544567
92Choanal stenosis (HP:0000452)2.37452145
93Fetal akinesia sequence (HP:0001989)2.36841281
94Abnormality of secondary sexual hair (HP:0009888)2.35866972
95Abnormality of the axillary hair (HP:0100134)2.35866972
96Tubular atrophy (HP:0000092)2.35382638
97Abnormal rod and cone electroretinograms (HP:0008323)2.34623527
98Focal motor seizures (HP:0011153)2.34592051
99Stomach cancer (HP:0012126)2.31560300
100Abnormal ossification of hand bones (HP:0005921)2.30881525
101Ulnar bowing (HP:0003031)2.30634619
102Pendular nystagmus (HP:0012043)2.28020577
103Retinal dysplasia (HP:0007973)2.27297693
104Genital tract atresia (HP:0001827)2.26920681
105Keratoconus (HP:0000563)2.25189684
106Increased corneal curvature (HP:0100692)2.25189684
107Bony spicule pigmentary retinopathy (HP:0007737)2.25004903
108Congenital primary aphakia (HP:0007707)2.24964003
109Decreased circulating renin level (HP:0003351)2.22342406
110Hemiparesis (HP:0001269)2.22336944
111Adactyly (HP:0009776)2.21292285
112Sclerocornea (HP:0000647)2.20795643
113Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.20330431
114Abnormality of the fibula (HP:0002991)2.20191641
115Vaginal atresia (HP:0000148)2.20067783
116Renal cortical cysts (HP:0000803)2.19826122
117Cerebellar dysplasia (HP:0007033)2.19425106
118Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.18720880
119Abnormality of the distal phalanges of the toes (HP:0010182)2.17771671
120Furrowed tongue (HP:0000221)2.17548716
121Pachygyria (HP:0001302)2.17471359
122Hypoplastic left heart (HP:0004383)2.17081883
123Female pseudohermaphroditism (HP:0010458)2.15952347
124Menorrhagia (HP:0000132)2.14560835
125Abnormality of the corticospinal tract (HP:0002492)2.14324317
126Anencephaly (HP:0002323)2.13406953
127Hyperventilation (HP:0002883)2.12765958
128Conical tooth (HP:0000698)2.11930922
129Stridor (HP:0010307)2.10330554
130Bowed forearm bones (HP:0003956)2.09461319
131Bowing of the arm (HP:0006488)2.09461319
132Progressive inability to walk (HP:0002505)2.09259904
133Febrile seizures (HP:0002373)2.08521127
134Abnormality of the labia minora (HP:0012880)2.08378647
135Tubulointerstitial fibrosis (HP:0005576)2.07632219
136Femoral bowing (HP:0002980)2.07026773
137Long nose (HP:0003189)2.06900324
138Nephrogenic diabetes insipidus (HP:0009806)2.05758142
139Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.05709990
140Palpebral edema (HP:0100540)2.00178340
141Widely spaced teeth (HP:0000687)1.98391876
142Gaze-evoked nystagmus (HP:0000640)1.98170825
143Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98125974
144Congenital hepatic fibrosis (HP:0002612)1.98070346
145Chronic hepatic failure (HP:0100626)1.97309015
146Microretrognathia (HP:0000308)1.96593225
147Mixed hearing impairment (HP:0000410)1.95898990
148Hypoplastic toenails (HP:0001800)1.95667158
149Broad-based gait (HP:0002136)1.95050636
150Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.94169385
151Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.94002913
152Abnormality of the dental pulp (HP:0006479)1.93729744
153Bilateral microphthalmos (HP:0007633)1.93521126
154Abnormality of the fovea (HP:0000493)1.92608553
155Abnormality of the phalanges of the 2nd finger (HP:0009541)1.92383699
156Arnold-Chiari malformation (HP:0002308)1.89650986
157Scanning speech (HP:0002168)1.88945286
158Polydipsia (HP:0001959)1.88034637
159Abnormal drinking behavior (HP:0030082)1.88034637
160Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87786983
161Pseudobulbar signs (HP:0002200)1.87592080
162Rhinitis (HP:0012384)1.86833135
163Anterior segment dysgenesis (HP:0007700)1.84956261
164Progressive cerebellar ataxia (HP:0002073)1.84565305
165Abnormality of the phalanges of the 5th finger (HP:0004213)1.84187863
166Patellar aplasia (HP:0006443)1.83654950
167Focal seizures (HP:0007359)1.82445942
168Hypoplastic heart (HP:0001961)1.80935753
169Abnormality of permanent molar morphology (HP:0011071)1.80552089
170Abnormality of the dental root (HP:0006486)1.80552089
171Taurodontia (HP:0000679)1.80552089
172Occipital encephalocele (HP:0002085)1.79551203
173Proximal tubulopathy (HP:0000114)1.79398668
174Rickets (HP:0002748)1.79185923
175Labial hypoplasia (HP:0000066)1.78784313
176Scrotal hypoplasia (HP:0000046)1.77842331
177Petechiae (HP:0000967)1.76862368
178Abnormality of molar morphology (HP:0011070)1.76037935
179Abnormality of molar (HP:0011077)1.76037935
180Accelerated skeletal maturation (HP:0005616)1.73574540
181Hyperglycinuria (HP:0003108)1.72520586
182Abnormality of the clitoris (HP:0000056)1.72322548
183Syncope (HP:0001279)1.72306340
184Fair hair (HP:0002286)1.72282655
185Rimmed vacuoles (HP:0003805)1.72153973
186Epileptic encephalopathy (HP:0200134)1.72054787
187Hypophosphatemic rickets (HP:0004912)1.71785439
188Metabolic alkalosis (HP:0200114)1.69674882
189Generalized tonic-clonic seizures (HP:0002069)1.68897011
190Infertility (HP:0000789)1.68744056
191Lip pit (HP:0100267)1.67247684
192Abnormality of homocysteine metabolism (HP:0010919)1.66808549
193Poor coordination (HP:0002370)1.66399580
194Intellectual disability, severe (HP:0010864)1.65821097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.86867204
2TNIK4.37820905
3BMPR1B4.31838528
4ADRBK23.36470369
5MAPK152.40629780
6FRK2.40372014
7SGK22.22944701
8NUAK12.21439478
9FER2.07470461
10WNK32.04378466
11OBSCN1.93491910
12SGK31.92320087
13MUSK1.91145899
14SGK2231.90888545
15SGK4941.90888545
16TGFBR11.90371054
17PAK31.88978219
18MAPK131.86452914
19CASK1.84318503
20LATS11.83872880
21SIK11.77638063
22MST41.77210251
23BMPR21.70385631
24EPHA41.69445074
25TAOK31.63282328
26MAP3K41.56950910
27PHKG21.56075546
28PHKG11.56075546
29PRPF4B1.53635782
30HIPK21.51450721
31CAMKK21.50958335
32ZAK1.46333318
33ADRBK11.40287022
34CAMKK11.37767627
35TLK11.36643041
36MARK31.32857430
37STK31.31785413
38STK38L1.31710376
39ERBB31.30712852
40MINK11.28886442
41SIK31.26097788
42MAP3K71.25414099
43CSNK1A1L1.23423850
44CLK11.21748238
45WNK41.17020043
46EPHB21.16869770
47RPS6KB21.15095781
48NME11.14018598
49NTRK31.11067008
50NEK21.07835361
51MARK11.07768343
52NTRK21.05501130
53MAP4K21.03222272
54PTK2B1.00125713
55PRKCE0.98991548
56MAPK120.98514466
57RIPK40.97927127
58SIK20.94668530
59CAMK2A0.91406059
60MAPKAPK30.89843175
61FGR0.88575146
62SGK10.87930497
63PRKCG0.87035956
64STK390.86813706
65PBK0.86666782
66PNCK0.86540599
67CSNK1G20.85673555
68OXSR10.85628002
69YES10.85061779
70INSRR0.84677525
71TYRO30.84638210
72NEK60.83212691
73MAP2K70.83168610
74CAMK2B0.79956013
75MAPK70.79885461
76ROCK10.79652678
77LMTK20.79010375
78CAMK2D0.77205671
79CDK80.76480376
80TNK20.75505204
81DAPK20.74381083
82PINK10.73641055
83PIK3CG0.70092942
84CDC42BPA0.69703011
85PKN10.69353263
86CAMK2G0.69123980
87MAP2K60.68179273
88PAK60.68033088
89CSF1R0.67760866
90MAP2K10.67541556
91CDK50.67533859
92CSNK1G30.66607547
93DYRK20.65471535
94MAP3K30.65059078
95FGFR30.64447456
96WNK10.64423841
97CAMK1G0.63676245
98MKNK20.62328783
99PDGFRA0.62267600
100MYLK0.62160043
101MKNK10.61898364
102PRKD10.61338747
103GRK10.61321022
104MARK20.60980765
105TIE10.60569197
106STK380.58850465
107CDK60.58838692
108TEC0.58838304
109AKT30.58764052
110PRKCI0.56558708
111PLK40.56460737
112CAMK1D0.55550271
113FGFR20.55085343
114MAP3K90.54489811
115MAP2K40.54411739
116PRKG10.52751994
117CAMK10.52386368
118BTK0.51743896
119PRKCH0.51321835
120PIK3CA0.51037881
121SYK0.50301444
122INSR0.50241043
123DMPK0.49504434
124CSNK1A10.49270370
125TRIM280.46929071
126NTRK10.46600375
127PRKACA0.46500172
128PRKG20.46318318
129BCR0.46303763
130CSNK1G10.46032282
131JAK10.44667163
132PRKCQ0.44062658
133MAP2K30.43948726
134TAOK10.42895067
135IRAK10.42310113
136DYRK1A0.42165694
137PRKCA0.40601464
138PLK20.40564090
139PRKCZ0.39852857
140DYRK30.39823236
141MAP2K20.39701027
142ERBB20.38083911
143MATK0.37578186
144CSNK1D0.37462469
145CDK30.37376919
146BMX0.37264618
147CAMK40.37109651
148RPS6KA50.34655904
149IKBKB0.33146517
150PRKAA20.32264098
151PRKACG0.32017894
152NEK10.31575474
153NEK90.31024405
154GRK50.30528471
155BRSK20.29626592

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.60217350
2Pentose and glucuronate interconversions_Homo sapiens_hsa000403.87686495
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.62292298
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.51198991
5Chemical carcinogenesis_Homo sapiens_hsa052043.05775431
6Sulfur relay system_Homo sapiens_hsa041222.81294051
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.74488011
8Phototransduction_Homo sapiens_hsa047442.63326127
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.47345774
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43984459
11Linoleic acid metabolism_Homo sapiens_hsa005912.31881706
12Fatty acid biosynthesis_Homo sapiens_hsa000611.94431653
13Steroid hormone biosynthesis_Homo sapiens_hsa001401.89229765
14ABC transporters_Homo sapiens_hsa020101.78683183
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68019766
16Caffeine metabolism_Homo sapiens_hsa002321.57015586
17Olfactory transduction_Homo sapiens_hsa047401.51166935
18Nitrogen metabolism_Homo sapiens_hsa009101.44956366
19Gastric acid secretion_Homo sapiens_hsa049711.44905361
20Tryptophan metabolism_Homo sapiens_hsa003801.44587527
21Platelet activation_Homo sapiens_hsa046111.39013880
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.35947822
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34636762
24Mineral absorption_Homo sapiens_hsa049781.33718233
25Retinol metabolism_Homo sapiens_hsa008301.33193036
26Circadian entrainment_Homo sapiens_hsa047131.30589445
27Nicotine addiction_Homo sapiens_hsa050331.29673358
28Starch and sucrose metabolism_Homo sapiens_hsa005001.27726669
29Arachidonic acid metabolism_Homo sapiens_hsa005901.26380762
30Bile secretion_Homo sapiens_hsa049761.25027315
31GABAergic synapse_Homo sapiens_hsa047271.22956135
32Ether lipid metabolism_Homo sapiens_hsa005651.22689602
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19978035
34Histidine metabolism_Homo sapiens_hsa003401.19645468
35Circadian rhythm_Homo sapiens_hsa047101.19520006
36Morphine addiction_Homo sapiens_hsa050321.15461584
37Salivary secretion_Homo sapiens_hsa049701.14264467
38beta-Alanine metabolism_Homo sapiens_hsa004101.12361472
39Glutamatergic synapse_Homo sapiens_hsa047241.11426949
40Sphingolipid metabolism_Homo sapiens_hsa006001.06240236
41Glutathione metabolism_Homo sapiens_hsa004801.03581416
42Basal transcription factors_Homo sapiens_hsa030221.03293958
43Glycerolipid metabolism_Homo sapiens_hsa005611.02469995
44Synaptic vesicle cycle_Homo sapiens_hsa047211.00884968
45Fatty acid degradation_Homo sapiens_hsa000711.00447575
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00207429
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99793347
48Arginine biosynthesis_Homo sapiens_hsa002200.95667273
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95500804
50Insulin secretion_Homo sapiens_hsa049110.94727136
51Collecting duct acid secretion_Homo sapiens_hsa049660.93546854
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90455145
53Melanogenesis_Homo sapiens_hsa049160.86746343
54Amphetamine addiction_Homo sapiens_hsa050310.84755139
55Butanoate metabolism_Homo sapiens_hsa006500.84450330
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83791803
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83003856
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78552784
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78381623
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77394604
61Cardiac muscle contraction_Homo sapiens_hsa042600.76760157
62Calcium signaling pathway_Homo sapiens_hsa040200.74983985
63Taste transduction_Homo sapiens_hsa047420.72240346
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72183270
65Long-term potentiation_Homo sapiens_hsa047200.71820305
66Steroid biosynthesis_Homo sapiens_hsa001000.71480133
67Basal cell carcinoma_Homo sapiens_hsa052170.69968485
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69666287
69Adherens junction_Homo sapiens_hsa045200.69110628
70Fatty acid metabolism_Homo sapiens_hsa012120.66717898
71cAMP signaling pathway_Homo sapiens_hsa040240.66223359
72Cocaine addiction_Homo sapiens_hsa050300.65690475
73Cholinergic synapse_Homo sapiens_hsa047250.65312656
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64264644
75Rheumatoid arthritis_Homo sapiens_hsa053230.64251957
76Regulation of autophagy_Homo sapiens_hsa041400.63718597
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63405109
78Serotonergic synapse_Homo sapiens_hsa047260.62475796
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61697930
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61369900
81Gap junction_Homo sapiens_hsa045400.60585063
82Renin secretion_Homo sapiens_hsa049240.60346451
83Phenylalanine metabolism_Homo sapiens_hsa003600.60181949
84PPAR signaling pathway_Homo sapiens_hsa033200.59244344
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.58714089
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57778965
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56014812
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.55667002
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.55506815
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53843759
91Tyrosine metabolism_Homo sapiens_hsa003500.53674345
92Arginine and proline metabolism_Homo sapiens_hsa003300.52896120
93Tight junction_Homo sapiens_hsa045300.52845159
94Dorso-ventral axis formation_Homo sapiens_hsa043200.52617076
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.52235590
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51882031
97GnRH signaling pathway_Homo sapiens_hsa049120.51856751
98Homologous recombination_Homo sapiens_hsa034400.50213906
99Axon guidance_Homo sapiens_hsa043600.48926990
100Long-term depression_Homo sapiens_hsa047300.47543994
101Hippo signaling pathway_Homo sapiens_hsa043900.47529137
102Dopaminergic synapse_Homo sapiens_hsa047280.46981507
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46783728
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46689197
105Fatty acid elongation_Homo sapiens_hsa000620.46505808
106Vitamin digestion and absorption_Homo sapiens_hsa049770.45237935
107Rap1 signaling pathway_Homo sapiens_hsa040150.44232699
108Pancreatic secretion_Homo sapiens_hsa049720.43767322
109African trypanosomiasis_Homo sapiens_hsa051430.43733087
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43569282
111Peroxisome_Homo sapiens_hsa041460.43543380
112Dilated cardiomyopathy_Homo sapiens_hsa054140.43539786
113Vibrio cholerae infection_Homo sapiens_hsa051100.43412810
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41256497
115Hematopoietic cell lineage_Homo sapiens_hsa046400.40580206
116Ras signaling pathway_Homo sapiens_hsa040140.40371938
117Parkinsons disease_Homo sapiens_hsa050120.39997978
118ErbB signaling pathway_Homo sapiens_hsa040120.39644740
119Oxytocin signaling pathway_Homo sapiens_hsa049210.38708637
120Proteoglycans in cancer_Homo sapiens_hsa052050.37917755
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37603193
122Wnt signaling pathway_Homo sapiens_hsa043100.37484367
123Choline metabolism in cancer_Homo sapiens_hsa052310.37460073
124Notch signaling pathway_Homo sapiens_hsa043300.37459568
125Thyroid hormone synthesis_Homo sapiens_hsa049180.37307901
126Fanconi anemia pathway_Homo sapiens_hsa034600.36831754
127Ovarian steroidogenesis_Homo sapiens_hsa049130.36382719
128Propanoate metabolism_Homo sapiens_hsa006400.36012293
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.35356313
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33525268
131Oxidative phosphorylation_Homo sapiens_hsa001900.32436618

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