ATP1A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)4.25944247
2cytoskeletal anchoring at plasma membrane (GO:0007016)4.18842503
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.12478447
4lysine catabolic process (GO:0006554)4.06694326
5lysine metabolic process (GO:0006553)4.06694326
6protein retention in ER lumen (GO:0006621)4.02475207
7phosphate ion transport (GO:0006817)3.77621853
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.68617916
9drug transmembrane transport (GO:0006855)3.56739946
10phosphate ion transmembrane transport (GO:0035435)3.53279321
11activation of Rac GTPase activity (GO:0032863)3.48231869
12drug catabolic process (GO:0042737)3.47071566
13bundle of His cell to Purkinje myocyte communication (GO:0086069)3.40194220
14proline biosynthetic process (GO:0006561)3.28533754
15actin filament depolymerization (GO:0030042)3.28351348
16regulation of cholesterol homeostasis (GO:2000188)3.24008617
17glucose 6-phosphate metabolic process (GO:0051156)3.21343017
18* cell communication involved in cardiac conduction (GO:0086065)3.17420856
19* sodium ion export (GO:0071436)3.16658493
20* cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.16041112
21intestinal absorption (GO:0050892)3.15297033
22synaptic vesicle maturation (GO:0016188)3.02815886
23drug transport (GO:0015893)3.01463741
24tricarboxylic acid metabolic process (GO:0072350)3.00200744
25protein localization to endosome (GO:0036010)2.98794964
26negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.97896302
27exogenous drug catabolic process (GO:0042738)2.95773767
28plasma membrane repair (GO:0001778)2.95674599
29aspartate family amino acid catabolic process (GO:0009068)2.94698096
30cell-substrate adherens junction assembly (GO:0007045)2.93783374
31focal adhesion assembly (GO:0048041)2.93783374
32regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.92224954
33negative regulation of potassium ion transmembrane transport (GO:1901380)2.90808459
34locomotory exploration behavior (GO:0035641)2.88010493
35negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.87922416
36very-low-density lipoprotein particle assembly (GO:0034379)2.81820922
37NADH metabolic process (GO:0006734)2.80499794
38embryonic process involved in female pregnancy (GO:0060136)2.80391363
39activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.78918233
40renal absorption (GO:0070293)2.78880259
41ventricular cardiac muscle cell action potential (GO:0086005)2.78634642
42surfactant homeostasis (GO:0043129)2.77857706
43layer formation in cerebral cortex (GO:0021819)2.77211955
44negative regulation of fatty acid transport (GO:2000192)2.77073035
45positive regulation of synapse maturation (GO:0090129)2.76618281
46quaternary ammonium group transport (GO:0015697)2.76300204
47regulation of cholesterol biosynthetic process (GO:0045540)2.76144835
48skin morphogenesis (GO:0043589)2.76080122
49glutamine family amino acid biosynthetic process (GO:0009084)2.74898032
50cell volume homeostasis (GO:0006884)2.74238105
51amino-acid betaine transport (GO:0015838)2.73485708
52carnitine transport (GO:0015879)2.73485708
532-oxoglutarate metabolic process (GO:0006103)2.73361417
54response to mercury ion (GO:0046689)2.72916144
55vesicle coating (GO:0006901)2.72905877
56hemidesmosome assembly (GO:0031581)2.70870039
57activation of protein kinase A activity (GO:0034199)2.69948065
58activation of MAPKKK activity (GO:0000185)2.69942509
59amino acid import (GO:0043090)2.69111632
60* cell communication by electrical coupling (GO:0010644)2.68866533
61urate metabolic process (GO:0046415)2.68344287
62mating behavior (GO:0007617)2.67446053
63dicarboxylic acid biosynthetic process (GO:0043650)2.67306294
64positive regulation of nuclease activity (GO:0032075)2.66337878
65response to parathyroid hormone (GO:0071107)2.65561009
66sexual reproduction (GO:0019953)2.60374844
67urea cycle (GO:0000050)2.59627708
68regulation of short-term neuronal synaptic plasticity (GO:0048172)2.59385123
69branching involved in mammary gland duct morphogenesis (GO:0060444)2.59096717
70regulation of bile acid biosynthetic process (GO:0070857)2.58126372
71myelin maintenance (GO:0043217)2.57936412
72regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.57422216
73epithelial cell-cell adhesion (GO:0090136)2.56834244
74tricarboxylic acid cycle (GO:0006099)2.56261543
75cellular response to epidermal growth factor stimulus (GO:0071364)2.54883886
76adhesion of symbiont to host (GO:0044406)2.54628502
77proline transport (GO:0015824)2.53906306
78proline metabolic process (GO:0006560)2.53742118
79protein-lipid complex assembly (GO:0065005)2.53293528
80fructose metabolic process (GO:0006000)2.52968635
81negative regulation of sodium ion transport (GO:0010766)2.50629975
82negative regulation of dendrite morphogenesis (GO:0050774)2.50512063
83cysteine metabolic process (GO:0006534)2.50388657
84regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.49097811
85semaphorin-plexin signaling pathway (GO:0071526)2.49024453
86regulation of glucose import in response to insulin stimulus (GO:2001273)2.48914312
87positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.48881901
88angiotensin maturation (GO:0002003)2.48870246
89regulation of clathrin-mediated endocytosis (GO:2000369)2.47030358
90excretion (GO:0007588)2.46886333
91establishment of nucleus localization (GO:0040023)2.46090551
92regulation of NFAT protein import into nucleus (GO:0051532)2.45364805
93epithelial cell differentiation involved in prostate gland development (GO:0060742)2.44560754
94positive regulation of sodium ion transport (GO:0010765)2.44478197
95plasma lipoprotein particle assembly (GO:0034377)2.44172014
96intestinal cholesterol absorption (GO:0030299)2.44124684
97glycosphingolipid catabolic process (GO:0046479)2.43333277
98basement membrane organization (GO:0071711)2.42990166
99regulation of nucleobase-containing compound transport (GO:0032239)2.42514732
100glutamate secretion (GO:0014047)2.41993379
101endoplasmic reticulum unfolded protein response (GO:0030968)2.41720540
102ER-nucleus signaling pathway (GO:0006984)2.40776924
103cellular copper ion homeostasis (GO:0006878)2.40654926
104receptor recycling (GO:0001881)2.39614779
105regulation of cholesterol metabolic process (GO:0090181)2.39368441
106bicarbonate transport (GO:0015701)2.39132138
107cell-cell junction maintenance (GO:0045217)2.38246668
108regulation of extracellular matrix disassembly (GO:0010715)2.38008930
1094-hydroxyproline metabolic process (GO:0019471)2.37949785
110synaptic vesicle docking involved in exocytosis (GO:0016081)2.37407762
111regulation of nuclease activity (GO:0032069)2.36923705
112regulation of mammary gland epithelial cell proliferation (GO:0033599)2.36806947
113regulation of early endosome to late endosome transport (GO:2000641)2.36473005
114endocytic recycling (GO:0032456)2.36456679
115cerebellar granule cell differentiation (GO:0021707)2.35703277
116macroautophagy (GO:0016236)2.33840301
117L-amino acid import (GO:0043092)2.33282598
118synaptic vesicle exocytosis (GO:0016079)2.33201929
119urea metabolic process (GO:0019627)2.32214759
120cardiac conduction (GO:0061337)2.31593654
121negative regulation of cell size (GO:0045792)2.31487685
122glutamate metabolic process (GO:0006536)2.31253582
123stress fiber assembly (GO:0043149)2.31142363
124beta-amyloid metabolic process (GO:0050435)2.30751221
125regulation of sodium ion transmembrane transporter activity (GO:2000649)2.30648682
126modified amino acid transport (GO:0072337)2.30421123
127response to epidermal growth factor (GO:0070849)2.30168609
128growth hormone receptor signaling pathway (GO:0060396)2.29913738
129carnitine shuttle (GO:0006853)2.29111415
130short-chain fatty acid metabolic process (GO:0046459)2.28402965
131regulation of heart rate by cardiac conduction (GO:0086091)2.28287351
132flavonoid metabolic process (GO:0009812)2.28243515
133barbed-end actin filament capping (GO:0051016)2.28227558
134hypotonic response (GO:0006971)2.27926912
135glycolipid catabolic process (GO:0019377)2.27763313
136vitamin transmembrane transport (GO:0035461)2.27457258
137oxaloacetate metabolic process (GO:0006107)2.27425468
138cellular modified amino acid catabolic process (GO:0042219)2.27201065
139positive regulation of nitric-oxide synthase activity (GO:0051000)2.26437740
140COPI coating of Golgi vesicle (GO:0048205)2.26265457
141Golgi transport vesicle coating (GO:0048200)2.26265457
142multicellular organismal water homeostasis (GO:0050891)2.25884438
143hormone catabolic process (GO:0042447)2.25114975
144apoptotic cell clearance (GO:0043277)2.24890611
145regulation of histone H3-K27 methylation (GO:0061085)2.24871192
146gap junction assembly (GO:0016264)2.24752005
147positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.24568431
148regulation of p38MAPK cascade (GO:1900744)2.24318284
149cellular response to prostaglandin stimulus (GO:0071379)2.24276454
150cellular response to reactive nitrogen species (GO:1902170)2.24045663
151COPII vesicle coating (GO:0048208)2.23966493
152regulation of ARF protein signal transduction (GO:0032012)2.23611414
153positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.21832992
154positive regulation of potassium ion transmembrane transport (GO:1901381)2.21648765
155carnitine transmembrane transport (GO:1902603)2.21605273
156* membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.19862885
157regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.19429419
158homocysteine metabolic process (GO:0050667)2.18768648
159cell-substrate junction assembly (GO:0007044)2.18350901
160regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.17779793
161regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.15652936
162adherens junction assembly (GO:0034333)2.14847623
163protein targeting to plasma membrane (GO:0072661)2.14827126
164alanine transport (GO:0032328)2.14811697
165protein targeting to Golgi (GO:0000042)2.13787304
166neuromuscular process controlling balance (GO:0050885)2.12547378
167* cellular potassium ion homeostasis (GO:0030007)2.10128325
168peptide catabolic process (GO:0043171)2.09983115
169actin filament capping (GO:0051693)2.09349117
170establishment of protein localization to Golgi (GO:0072600)2.09167817
171organic cation transport (GO:0015695)2.09124780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human2.76715835
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.40294840
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39472492
4ESR2_21235772_ChIP-Seq_MCF-7_Human2.35064895
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.29344226
6ZNF263_19887448_ChIP-Seq_K562_Human2.28887022
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.08074046
8* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.01908511
9MYC_22102868_ChIP-Seq_BL_Human1.96298237
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95190794
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94122049
12CLOCK_20551151_ChIP-Seq_293T_Human1.91494595
13RXR_22158963_ChIP-Seq_LIVER_Mouse1.89854362
14DROSHA_22980978_ChIP-Seq_HELA_Human1.88017644
15EGR1_19374776_ChIP-ChIP_THP-1_Human1.87876300
16PPARA_22158963_ChIP-Seq_LIVER_Mouse1.83962599
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82571323
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.82431606
19LXR_22158963_ChIP-Seq_LIVER_Mouse1.82276028
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.77572715
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75165689
22* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73955199
23* KDM2B_26808549_Chip-Seq_K562_Human1.73852005
24* LXR_22292898_ChIP-Seq_THP-1_Human1.73719814
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70673236
26SOX2_27498859_Chip-Seq_STOMACH_Mouse1.66613661
27* RACK7_27058665_Chip-Seq_MCF-7_Human1.65051537
28CDX2_20551321_ChIP-Seq_CACO-2_Human1.64895068
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.61137450
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.56756262
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55198710
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.54818516
33KDM2B_26808549_Chip-Seq_DND41_Human1.53599040
34AR_21909140_ChIP-Seq_LNCAP_Human1.53479778
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.51246511
36* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48186708
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.47157793
38* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44696690
39VDR_21846776_ChIP-Seq_THP-1_Human1.44239009
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.42892117
41FOXA2_19822575_ChIP-Seq_HepG2_Human1.41723806
42RUNX1_27514584_Chip-Seq_MCF-7_Human1.41669029
43* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.41418719
44* RARB_27405468_Chip-Seq_BRAIN_Mouse1.40123869
45TBX20_22328084_ChIP-Seq_HEART_Mouse1.34445482
46TBX20_22080862_ChIP-Seq_HEART_Mouse1.34445482
47* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33944130
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33612482
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33048070
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32823188
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31789381
52* CREB1_26743006_Chip-Seq_LNCaP_Human1.31653994
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31207649
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31025277
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30803490
56* EP300_21415370_ChIP-Seq_HL-1_Mouse1.28825789
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28464946
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28358849
59SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27506635
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27423749
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27270338
62CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26419171
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26317602
64* ATF3_27146783_Chip-Seq_COLON_Human1.26180269
65* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26113382
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25813003
67EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25280085
68RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25280085
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24422823
70* GATA6_25053715_ChIP-Seq_YYC3_Human1.24094784
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23713303
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23278156
73GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.22951029
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22703249
75* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21935609
76* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21662829
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21638026
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21210624
79* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20636977
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20373057
81* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19481917
82* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19072954
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17142908
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.15025586
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15000335
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14337544
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.13403059
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13207023
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13038481
90GATA1_19941826_ChIP-Seq_K562_Human1.12876793
91TCF7_22412390_ChIP-Seq_EML_Mouse1.12736325
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11122056
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10563096
94UBF1/2_26484160_Chip-Seq_HMECs_Human1.09666769
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08145689
96* ELK3_25401928_ChIP-Seq_HUVEC_Human1.07805145
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06470014
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05995419
99AHR_22903824_ChIP-Seq_MCF-7_Human1.05268806
100* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04539186
101CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04536529
102SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04236349
103ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04209460
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04066358
105NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03741367
106* GATA4_25053715_ChIP-Seq_YYC3_Human1.02942712
107* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02689290
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02543294
109* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02415940
110SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02319478
111SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02251876
112* TET1_21490601_ChIP-Seq_MESCs_Mouse1.01491178
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01322280
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01244121
115NCOR1_26117541_ChIP-Seq_K562_Human1.00789158
116* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99827324
117* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98910652
118* P68_20966046_ChIP-Seq_HELA_Human0.98341414
119SOX2_20726797_ChIP-Seq_SW620_Human0.98089692
120* KLF5_25053715_ChIP-Seq_YYC3_Human0.97417180
121JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96565618
122GATA1_22025678_ChIP-Seq_K562_Human0.96186715
123SA1_27219007_Chip-Seq_ERYTHROID_Human0.96175386
124FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95859164
125SMAD3_21741376_ChIP-Seq_HESCs_Human0.95546589
126EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95279606
127SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94916821
128SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94916821
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94815731
130* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94020052
131* GATA2_19941826_ChIP-Seq_K562_Human0.93953315
132CTCF_27219007_Chip-Seq_Bcells_Human0.93868904
133SMC4_20622854_ChIP-Seq_HELA_Human0.93282207
134RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92405885
135* TP63_22573176_ChIP-Seq_HFKS_Human0.90751131
136STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90674243
137ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90525738
138NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89646241

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.73222294
2MP0010234_abnormal_vibrissa_follicle4.11552483
3MP0004043_abnormal_pH_regulation3.85115577
4MP0005409_darkened_coat_color3.53942928
5MP0003705_abnormal_hypodermis_morpholog2.76615058
6MP0003300_gastrointestinal_ulcer2.67570015
7MP0004859_abnormal_synaptic_plasticity2.56737992
8MP0000678_abnormal_parathyroid_gland2.53904915
9MP0004858_abnormal_nervous_system2.45557912
10MP0005377_hearing/vestibular/ear_phenot2.43812301
11MP0003878_abnormal_ear_physiology2.43812301
12MP0005451_abnormal_body_composition2.41328695
13MP0002139_abnormal_hepatobiliary_system2.34244150
14MP0003283_abnormal_digestive_organ2.33853757
15MP0008961_abnormal_basal_metabolism2.24362215
16MP0001765_abnormal_ion_homeostasis2.17660560
17MP0003252_abnormal_bile_duct2.15930059
18MP0005076_abnormal_cell_differentiation2.09683798
19MP0004084_abnormal_cardiac_muscle2.07053253
20MP0009780_abnormal_chondrocyte_physiolo2.04485078
21MP0005257_abnormal_intraocular_pressure2.03824450
22MP0001666_abnormal_nutrient_absorption2.03247266
23MP0003453_abnormal_keratinocyte_physiol1.90817074
24MP0009643_abnormal_urine_homeostasis1.86632779
25MP0005332_abnormal_amino_acid1.84835397
26MP0004019_abnormal_vitamin_homeostasis1.79382366
27MP0000566_synostosis1.75284438
28MP0003329_amyloid_beta_deposits1.74343688
29MP0001756_abnormal_urination1.71631991
30MP0004782_abnormal_surfactant_physiolog1.69640836
31MP0000751_myopathy1.68334436
32MP0002909_abnormal_adrenal_gland1.67505869
33MP0003195_calcinosis1.66189107
34MP0004264_abnormal_extraembryonic_tissu1.66087003
35MP0005167_abnormal_blood-brain_barrier1.65170931
36MP0003045_fibrosis1.62908085
37MP0000579_abnormal_nail_morphology1.61586252
38MP0004885_abnormal_endolymph1.58562286
39MP0009840_abnormal_foam_cell1.58490504
40MP0004270_analgesia1.57887888
41MP0005085_abnormal_gallbladder_physiolo1.57090576
42MP0008875_abnormal_xenobiotic_pharmacok1.55845349
43MP0000537_abnormal_urethra_morphology1.55127782
44MP0003091_abnormal_cell_migration1.54971062
45MP0008260_abnormal_autophagy1.52387323
46MP0003123_paternal_imprinting1.48468442
47MP0001849_ear_inflammation1.39803861
48MP0008438_abnormal_cutaneous_collagen1.38228598
49MP0001348_abnormal_lacrimal_gland1.37537740
50MP0001958_emphysema1.33291980
51MP0005501_abnormal_skin_physiology1.30246460
52MP0003566_abnormal_cell_adhesion1.30219650
53MP0002089_abnormal_postnatal_growth/wei1.29885516
54MP0004036_abnormal_muscle_relaxation1.29462799
55MP0004215_abnormal_myocardial_fiber1.28103748
56MP0010352_gastrointestinal_tract_polyps1.27486105
57MP0010329_abnormal_lipoprotein_level1.24577206
58MP0005423_abnormal_somatic_nervous1.23591204
59MP0003879_abnormal_hair_cell1.23576841
60MP0000747_muscle_weakness1.22711158
61MP0002136_abnormal_kidney_physiology1.21715390
62MP0003866_abnormal_defecation1.20621668
63MP0005365_abnormal_bile_salt1.20061883
64MP0002098_abnormal_vibrissa_morphology1.17915595
65MP0004484_altered_response_of1.16950388
66MP0000604_amyloidosis1.16771346
67MP0002877_abnormal_melanocyte_morpholog1.16423195
68MP0002837_dystrophic_cardiac_calcinosis1.15504555
69MP0005023_abnormal_wound_healing1.13294763
70MP0000920_abnormal_myelination1.12741706
71MP0000538_abnormal_urinary_bladder1.12641023
72MP0003191_abnormal_cellular_cholesterol1.11370628
73MP0005058_abnormal_lysosome_morphology1.10946169
74MP0003635_abnormal_synaptic_transmissio1.10472011
75MP0002138_abnormal_hepatobiliary_system1.10356936
76MP0005636_abnormal_mineral_homeostasis1.10223400
77MP0005623_abnormal_meninges_morphology1.10151625
78MP0005408_hypopigmentation1.09911223
79MP0004947_skin_inflammation1.08536983
80MP0004130_abnormal_muscle_cell1.08266192
81MP0002896_abnormal_bone_mineralization1.06237184
82MP0002822_catalepsy1.05778991
83MP0000003_abnormal_adipose_tissue1.04870325
84MP0004147_increased_porphyrin_level1.03973209
85MP0004233_abnormal_muscle_weight1.02584364
86MP0003634_abnormal_glial_cell1.02200935
87MP0004087_abnormal_muscle_fiber1.02071758
88MP0002060_abnormal_skin_morphology1.00844183
89MP0000681_abnormal_thyroid_gland1.00173867
90MP0006138_congestive_heart_failure1.00087061
91MP0001216_abnormal_epidermal_layer0.96612451
92MP0002735_abnormal_chemical_nociception0.95411469
93MP0005330_cardiomyopathy0.95400869
94MP0003868_abnormal_feces_composition0.95286902
95MP0001730_embryonic_growth_arrest0.94842234
96MP0003183_abnormal_peptide_metabolism0.94835531
97MP0005083_abnormal_biliary_tract0.94534612
98MP0008569_lethality_at_weaning0.93159335
99MP0009672_abnormal_birth_weight0.92074700
100MP0003075_altered_response_to0.91722482
101MP0005165_increased_susceptibility_to0.91290965
102MP0000534_abnormal_ureter_morphology0.91218867
103MP0000467_abnormal_esophagus_morphology0.90937936
104MP0005666_abnormal_adipose_tissue0.89932335
105MP0004510_myositis0.89680548
106MP0008775_abnormal_heart_ventricle0.89670876
107MP0005621_abnormal_cell_physiology0.87858501
108MP0000477_abnormal_intestine_morphology0.87259000
109MP0005187_abnormal_penis_morphology0.87191953
110MP0000462_abnormal_digestive_system0.86516005
111MP0002269_muscular_atrophy0.86015532
112MP0003690_abnormal_glial_cell0.85509357
113MP0002168_other_aberrant_phenotype0.84670305
114* MP0002972_abnormal_cardiac_muscle0.84623954
115MP0009046_muscle_twitch0.84237122
116MP0005584_abnormal_enzyme/coenzyme_acti0.83208127
117MP0000377_abnormal_hair_follicle0.83042667
118MP0002234_abnormal_pharynx_morphology0.81304433
119MP0004272_abnormal_basement_membrane0.80715836
120MP0010678_abnormal_skin_adnexa0.79230828
121MP0002118_abnormal_lipid_homeostasis0.78903716
122MP0010630_abnormal_cardiac_muscle0.78823695
123MP0000569_abnormal_digit_pigmentation0.77326202
124MP0000858_altered_metastatic_potential0.75965501
125MP0004185_abnormal_adipocyte_glucose0.75933158
126MP0002734_abnormal_mechanical_nocicepti0.74878883
127MP0000762_abnormal_tongue_morphology0.74808169
128MP0005166_decreased_susceptibility_to0.74766948
129MP0003172_abnormal_lysosome_physiology0.74751487
130MP0001346_abnormal_lacrimal_gland0.73837606
131MP0003646_muscle_fatigue0.73664394
132MP0000230_abnormal_systemic_arterial0.73595365
133MP0002998_abnormal_bone_remodeling0.73065348
134MP0005171_absent_coat_pigmentation0.71868662
135MP0002796_impaired_skin_barrier0.71819490
136MP0001968_abnormal_touch/_nociception0.71515402
137MP0005375_adipose_tissue_phenotype0.71086852
138MP0002249_abnormal_larynx_morphology0.70954685
139MP0003633_abnormal_nervous_system0.70552773
140MP0001664_abnormal_digestion0.70263844
141MP0010155_abnormal_intestine_physiology0.70203306
142MP0005319_abnormal_enzyme/_coenzyme0.69810460
143MP0004085_abnormal_heartbeat0.67255439
144MP0000627_abnormal_mammary_gland0.66829008
145MP0000490_abnormal_crypts_of0.65377990
146MP0002086_abnormal_extraembryonic_tissu0.63192842
147MP0002064_seizures0.60867700
148MP0008874_decreased_physiological_sensi0.60822518
149MP0003303_peritoneal_inflammation0.60663717

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)4.43003324
2Increased circulating renin level (HP:0000848)4.38038835
3Metabolic alkalosis (HP:0200114)4.34329096
4Hypokalemic alkalosis (HP:0001949)4.11170554
5Abnormality of chloride homeostasis (HP:0011422)4.08115707
6Gout (HP:0001997)3.92587896
7Abnormality of glutamine family amino acid metabolism (HP:0010902)3.28183373
8Right ventricular cardiomyopathy (HP:0011663)3.25198860
9Abnormal urine output (HP:0012590)3.18457063
10Polyuria (HP:0000103)3.10497714
11Abnormality of renin-angiotensin system (HP:0000847)3.09352577
12Neurofibrillary tangles (HP:0002185)3.08495033
13Cerebral inclusion bodies (HP:0100314)3.00300554
14Abnormality of renal excretion (HP:0011036)2.97922816
15Ventricular fibrillation (HP:0001663)2.97843684
16Hyperaldosteronism (HP:0000859)2.97142548
17Hypomagnesemia (HP:0002917)2.97100238
18Bundle branch block (HP:0011710)2.84356588
19Renal salt wasting (HP:0000127)2.77015663
20Hand muscle atrophy (HP:0009130)2.76889011
21Supranuclear gaze palsy (HP:0000605)2.74501541
22Action tremor (HP:0002345)2.72954494
23Dysmetric saccades (HP:0000641)2.72401783
24Abnormality of magnesium homeostasis (HP:0004921)2.71923609
25Upper limb amyotrophy (HP:0009129)2.68839756
26Distal upper limb amyotrophy (HP:0007149)2.68839756
27Hyperparathyroidism (HP:0000843)2.67554493
28Ketoacidosis (HP:0001993)2.66284305
29Alkalosis (HP:0001948)2.62678790
30Hyperuricemia (HP:0002149)2.60178201
31Increased purine levels (HP:0004368)2.60178201
32Hypercalciuria (HP:0002150)2.55783538
33Deep venous thrombosis (HP:0002625)2.53500168
34Tetany (HP:0001281)2.53350924
35Abnormality of proline metabolism (HP:0010907)2.48806057
36Hydroxyprolinuria (HP:0003080)2.48806057
37Polydipsia (HP:0001959)2.45603560
38Abnormal drinking behavior (HP:0030082)2.45603560
39Abnormality of purine metabolism (HP:0004352)2.44639202
40Hypokalemia (HP:0002900)2.43267806
41Sudden death (HP:0001699)2.40424901
42Thin bony cortex (HP:0002753)2.34652247
43Broad face (HP:0000283)2.32263669
44Protrusio acetabuli (HP:0003179)2.32163519
45Lymphangioma (HP:0100764)2.29482980
46Hyperglycinuria (HP:0003108)2.28723621
47Distal lower limb amyotrophy (HP:0008944)2.28021040
48Adrenal overactivity (HP:0002717)2.27411671
49Obstructive sleep apnea (HP:0002870)2.26747339
50Vertebral compression fractures (HP:0002953)2.24902104
51Pili torti (HP:0003777)2.23305303
52Facial shape deformation (HP:0011334)2.23040105
53Potter facies (HP:0002009)2.23040105
54Syncope (HP:0001279)2.21151558
55Ankyloglossia (HP:0010296)2.17602816
56Asymmetry of the thorax (HP:0001555)2.16555443
57Abnormality of the lower motor neuron (HP:0002366)2.13288801
58Abnormality of potassium homeostasis (HP:0011042)2.12801926
59Abnormality of carpal bone ossification (HP:0006257)2.12687818
60Hemorrhage of the eye (HP:0011885)2.10953410
61Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.10251915
62Ileus (HP:0002595)2.08479681
63Abnormality of the salivary glands (HP:0010286)2.08405288
64Subacute progressive viral hepatitis (HP:0006572)2.06211267
65Abnormal gallbladder physiology (HP:0012438)2.03056601
66Cholecystitis (HP:0001082)2.03056601
67Spinal cord compression (HP:0002176)2.00812084
68Neuronal loss in central nervous system (HP:0002529)2.00736789
69Growth hormone excess (HP:0000845)2.00673476
70Flat acetabular roof (HP:0003180)2.00316890
71Cerebral aneurysm (HP:0004944)1.99871827
72Abnormality of the distal phalanx of the thumb (HP:0009617)1.99711406
73Focal segmental glomerulosclerosis (HP:0000097)1.99589126
74Malnutrition (HP:0004395)1.99451246
75Glomerulosclerosis (HP:0000096)1.99399644
76Achilles tendon contracture (HP:0001771)1.98729632
77Abnormality of the distal phalanges of the toes (HP:0010182)1.98562887
78Ketosis (HP:0001946)1.94808248
79Abnormal ossification of hand bones (HP:0005921)1.93955560
80Ventricular arrhythmia (HP:0004308)1.93044571
81Hyporeflexia of lower limbs (HP:0002600)1.92998846
82Bronchomalacia (HP:0002780)1.92497123
83Hyperacusis (HP:0010780)1.92496171
84Elfin facies (HP:0004428)1.92464735
85Lower limb amyotrophy (HP:0007210)1.92120044
86Aplasia involving bones of the extremities (HP:0009825)1.92055473
87Aplasia involving bones of the upper limbs (HP:0009823)1.92055473
88Aplasia of the phalanges of the hand (HP:0009802)1.92055473
89Proximal tubulopathy (HP:0000114)1.91556363
90Nephrolithiasis (HP:0000787)1.89163363
91Segmental peripheral demyelination/remyelination (HP:0003481)1.89147225
92Osteolytic defects of the hand bones (HP:0009699)1.89021816
93Osteolytic defects of the phalanges of the hand (HP:0009771)1.89021816
94Neonatal death (HP:0003811)1.88784644
95Ulnar bowing (HP:0003031)1.88775571
96Arterial tortuosity (HP:0005116)1.87213159
97Premature rupture of membranes (HP:0001788)1.86964249
98Advanced eruption of teeth (HP:0006288)1.86172350
99Abdominal distention (HP:0003270)1.84754128
100Ankle clonus (HP:0011448)1.84689436
101J-shaped sella turcica (HP:0002680)1.83866263
102Asymmetric septal hypertrophy (HP:0001670)1.83573685
103Myokymia (HP:0002411)1.80994492
104Exercise-induced muscle cramps (HP:0003710)1.80709143
105Distal lower limb muscle weakness (HP:0009053)1.78980141
106Relative macrocephaly (HP:0004482)1.77447803
107Aneurysm (HP:0002617)1.76693541
108Hypotension (HP:0002615)1.76680100
109Metaphyseal cupping (HP:0003021)1.76644727
110Abnormality of oral frenula (HP:0000190)1.76383358
111Broad metatarsal (HP:0001783)1.76328298
112Termporal pattern (HP:0011008)1.75709620
113Insidious onset (HP:0003587)1.75709620
114Visual hallucinations (HP:0002367)1.75550880
115Rectal prolapse (HP:0002035)1.75173377
116Visceral angiomatosis (HP:0100761)1.74760999
117Abnormality of glycine metabolism (HP:0010895)1.73865331
118Abnormality of serine family amino acid metabolism (HP:0010894)1.73865331
119Alacrima (HP:0000522)1.73584401
120Hyperphosphatemia (HP:0002905)1.72719856
121Myoglobinuria (HP:0002913)1.71644057
122Long toe (HP:0010511)1.70822666
123Hemiplegia (HP:0002301)1.69920459
124Skin nodule (HP:0200036)1.68348841
125Distal sensory impairment (HP:0002936)1.67991264
126Interstitial pulmonary disease (HP:0006530)1.67788237
127Abnormality of monocarboxylic acid metabolism (HP:0010996)1.67630298
128Short nail (HP:0001799)1.67578310
129Dehydration (HP:0001944)1.67040820
130Centrally nucleated skeletal muscle fibers (HP:0003687)1.66101152
131Lower limb asymmetry (HP:0100559)1.65975892
132Urinary glycosaminoglycan excretion (HP:0003541)1.65485339
133Mucopolysacchariduria (HP:0008155)1.65485339
134Late onset (HP:0003584)1.64721687
135Annular pancreas (HP:0001734)1.64669822
136Peripheral hypomyelination (HP:0007182)1.63878037
137Resting tremor (HP:0002322)1.63020380
138Enlarged penis (HP:0000040)1.63010196
139Shallow orbits (HP:0000586)1.62935012
140Abnormal tarsal ossification (HP:0008369)1.62810352
141Ventricular tachycardia (HP:0004756)1.62517680
142Goiter (HP:0000853)1.62216859
143Prolonged QT interval (HP:0001657)1.62042580
144Hemangiomatosis (HP:0007461)1.61749086
145Heart block (HP:0012722)1.61639640
146Neonatal onset (HP:0003623)1.61236999
147Decreased circulating renin level (HP:0003351)1.60641270
148Palpitations (HP:0001962)1.60454546
149Abnormal hair laboratory examination (HP:0003328)1.60451235
150Decreased motor nerve conduction velocity (HP:0003431)1.59942744
151Abnormality of sodium homeostasis (HP:0010931)1.59840031
152Depression (HP:0000716)1.59479230
153Abnormality of the Achilles tendon (HP:0005109)1.59278108
154Abnormality of the gastric mucosa (HP:0004295)1.59021672
155Insomnia (HP:0100785)1.58057801
156Hyperammonemia (HP:0001987)1.57977934
157Disproportionate tall stature (HP:0001519)1.57788338
158Hypercortisolism (HP:0001578)1.57680794
159Xanthomatosis (HP:0000991)1.57505314
160Germ cell neoplasia (HP:0100728)1.56669515
161Mildly elevated creatine phosphokinase (HP:0008180)1.56643768
162Increased CSF protein (HP:0002922)1.56404077
163Vascular tortuosity (HP:0004948)1.55684331
164Abnormality of complement system (HP:0005339)1.55549232
165Axonal loss (HP:0003447)1.55475506
166Apathy (HP:0000741)1.55137021
167Bone pain (HP:0002653)1.55102241
168Hypophosphatemia (HP:0002148)1.54342841
169Hammertoe (HP:0001765)1.54316999
170Back pain (HP:0003418)1.53206954
171Slow saccadic eye movements (HP:0000514)1.50931160

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK43.56996178
2TRIB33.48206010
3LMTK23.34835560
4RIPK13.08843090
5PRPF4B2.98044650
6PKN22.84852375
7CDK122.79130578
8SMG12.61785237
9MAP3K92.38245205
10OXSR12.35504309
11KSR22.32311412
12WNK32.31568333
13MST1R2.21972746
14MAP3K22.10617074
15PTK61.92988005
16IRAK31.91011754
17NEK11.71312913
18STK391.60926565
19FRK1.55081678
20PRKD31.54797498
21WNK11.54454810
22CAMKK11.54030165
23TTN1.49837057
24EEF2K1.49577871
25STK381.47740000
26NTRK11.46637635
27PDGFRA1.45102188
28MAP3K131.44956447
29SCYL21.44608090
30ARAF1.43628543
31DAPK21.42399950
32RET1.42300995
33PTK21.35317290
34EPHB11.28602701
35ERN11.27118574
36FER1.26572000
37PAK61.26360012
38TAOK11.22282300
39NTRK31.20519942
40BMX1.16847634
41MAP3K71.12809326
42TYRO31.09965655
43SGK31.08885549
44MINK11.05228506
45DMPK1.04547973
46LRRK21.04360748
47MET1.03930645
48LATS11.03646451
49RIPK41.03373874
50ALK0.96966947
51PAK30.95971773
52MAP3K30.95966042
53PDK40.93912300
54PDK30.93912300
55NEK60.93573911
56CAMKK20.92984788
57MAP3K10.92822170
58FGFR40.90223776
59PRKG20.88739838
60DDR20.86748828
61PRKCH0.86133378
62PAK40.85993366
63MAP3K100.84535773
64NME20.84358991
65TAOK20.81812392
66PDPK10.80983882
67MAP3K40.80962925
68EPHA20.80503755
69SIK10.80485344
70MAPK110.78348880
71LATS20.78120000
72ICK0.75953411
73SGK2230.73959576
74SGK4940.73959576
75PDK10.73508274
76MAP2K20.72309202
77CDC42BPA0.71058712
78PHKG10.69933203
79PHKG20.69933203
80CAMK1G0.69619538
81MAP2K40.69372564
82MAP2K10.67635084
83MARK20.64382912
84BRAF0.60707840
85KSR10.60347126
86CDK60.57944413
87PDGFRB0.55782538
88UHMK10.55382513
89STK110.55048518
90SGK20.54945388
91CDK150.54904490
92MAP3K80.54681166
93DAPK10.53049780
94CDK50.52021002
95PRKAA10.51781391
96FGFR10.51036175
97CDK180.50487865
98JAK20.49699959
99MTOR0.49604257
100FGFR30.49276825
101CDK11A0.49087988
102ERBB20.48727970
103CAMK1D0.48382480
104PDK20.48002536
105PRKD10.45888015
106EPHB20.45430780
107TESK20.45321910
108SIK20.44739314
109MAPK100.44507850
110JAK30.44085366
111PTK2B0.44029250
112MAP3K140.43791745
113MYLK0.43207756
114GRK60.42856653
115CAMK40.42741237
116RPS6KB20.42059209
117ROCK10.41948663
118AKT20.41771026
119BRD40.41406740
120IRAK20.41125074
121PAK20.39500557
122CDK140.39104759
123JAK10.38298630
124CAMK2B0.37373205
125SGK10.36216946
126MAPKAPK30.35438979
127EPHA40.35390538
128SRC0.35189181
129GSK3A0.34796068
130TESK10.34022285
131RPS6KA20.33662599
132MAPK120.33114799
133MATK0.32984388
134ROCK20.31871133
135MAP3K110.31707828
136NEK90.30726359
137RAF10.29537647

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.59397729
2* Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.47132419
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.18769316
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.15626654
5* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08478441
6* Bile secretion_Homo sapiens_hsa049761.93813554
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.91603363
8Other glycan degradation_Homo sapiens_hsa005111.69400403
9* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.64942940
10Arginine biosynthesis_Homo sapiens_hsa002201.55283381
11* Mineral absorption_Homo sapiens_hsa049781.50258962
12Prion diseases_Homo sapiens_hsa050201.48972944
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.47492402
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46622684
15Fatty acid degradation_Homo sapiens_hsa000711.46361982
16Fat digestion and absorption_Homo sapiens_hsa049751.42854379
17* Gastric acid secretion_Homo sapiens_hsa049711.41935123
18Thyroid cancer_Homo sapiens_hsa052161.41340063
19* Carbohydrate digestion and absorption_Homo sapiens_hsa049731.38968232
20Butanoate metabolism_Homo sapiens_hsa006501.28411289
21Chronic myeloid leukemia_Homo sapiens_hsa052201.26525788
22Type II diabetes mellitus_Homo sapiens_hsa049301.20882377
23Pentose phosphate pathway_Homo sapiens_hsa000301.20786612
24Non-small cell lung cancer_Homo sapiens_hsa052231.20215504
25ErbB signaling pathway_Homo sapiens_hsa040121.14748730
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14286969
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14095767
28* Thyroid hormone synthesis_Homo sapiens_hsa049181.14059419
29* Protein digestion and absorption_Homo sapiens_hsa049741.13302056
30Vitamin digestion and absorption_Homo sapiens_hsa049771.11922245
31Renin-angiotensin system_Homo sapiens_hsa046141.11356629
32Starch and sucrose metabolism_Homo sapiens_hsa005001.11294550
33Vibrio cholerae infection_Homo sapiens_hsa051101.11283343
34Long-term potentiation_Homo sapiens_hsa047201.10922931
35Synaptic vesicle cycle_Homo sapiens_hsa047211.10468233
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06236037
37Carbon metabolism_Homo sapiens_hsa012001.06190531
38* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04905372
39Phenylalanine metabolism_Homo sapiens_hsa003601.02753471
40Fatty acid biosynthesis_Homo sapiens_hsa000611.02278693
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00401782
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00243631
43Propanoate metabolism_Homo sapiens_hsa006400.99828991
44* Salivary secretion_Homo sapiens_hsa049700.99800262
45Sulfur metabolism_Homo sapiens_hsa009200.99269756
46Histidine metabolism_Homo sapiens_hsa003400.99166244
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98855724
48Fatty acid metabolism_Homo sapiens_hsa012120.97689734
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96805840
50PPAR signaling pathway_Homo sapiens_hsa033200.96722538
51Pancreatic cancer_Homo sapiens_hsa052120.95346697
52Pyruvate metabolism_Homo sapiens_hsa006200.94640034
53Tryptophan metabolism_Homo sapiens_hsa003800.93893253
54* Insulin secretion_Homo sapiens_hsa049110.93813712
55Renal cell carcinoma_Homo sapiens_hsa052110.93226149
56Dilated cardiomyopathy_Homo sapiens_hsa054140.91629425
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90346725
58Lysine degradation_Homo sapiens_hsa003100.88985347
59Dorso-ventral axis formation_Homo sapiens_hsa043200.88753264
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.88706285
61Insulin resistance_Homo sapiens_hsa049310.87623164
62Acute myeloid leukemia_Homo sapiens_hsa052210.87216576
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86829560
64Estrogen signaling pathway_Homo sapiens_hsa049150.85864030
65Arginine and proline metabolism_Homo sapiens_hsa003300.84542519
66Vitamin B6 metabolism_Homo sapiens_hsa007500.83938911
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82126402
68Hepatitis C_Homo sapiens_hsa051600.81921636
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81169118
70Glioma_Homo sapiens_hsa052140.80254725
71Circadian entrainment_Homo sapiens_hsa047130.80216659
72mTOR signaling pathway_Homo sapiens_hsa041500.80131495
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.79631540
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79268466
75GnRH signaling pathway_Homo sapiens_hsa049120.78479674
76Tight junction_Homo sapiens_hsa045300.76896336
77Small cell lung cancer_Homo sapiens_hsa052220.76619659
78Notch signaling pathway_Homo sapiens_hsa043300.76426490
79* Pancreatic secretion_Homo sapiens_hsa049720.76033957
80Fructose and mannose metabolism_Homo sapiens_hsa000510.75600640
81Glycerolipid metabolism_Homo sapiens_hsa005610.75455482
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75087977
83HIF-1 signaling pathway_Homo sapiens_hsa040660.75037694
84Galactose metabolism_Homo sapiens_hsa000520.74359376
85Sphingolipid metabolism_Homo sapiens_hsa006000.73821233
86Renin secretion_Homo sapiens_hsa049240.72657288
87Endometrial cancer_Homo sapiens_hsa052130.71918117
88Biosynthesis of amino acids_Homo sapiens_hsa012300.71098109
89Focal adhesion_Homo sapiens_hsa045100.69886922
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69254136
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69205951
92VEGF signaling pathway_Homo sapiens_hsa043700.67720114
93Olfactory transduction_Homo sapiens_hsa047400.66453451
94* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66146865
95Gap junction_Homo sapiens_hsa045400.66099485
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66096644
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66005804
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.65900392
99ECM-receptor interaction_Homo sapiens_hsa045120.65875345
100Oxytocin signaling pathway_Homo sapiens_hsa049210.65169243
101Glucagon signaling pathway_Homo sapiens_hsa049220.64602248
102Glutamatergic synapse_Homo sapiens_hsa047240.62827548
103Prostate cancer_Homo sapiens_hsa052150.62746824
104Amoebiasis_Homo sapiens_hsa051460.62588057
105Proteoglycans in cancer_Homo sapiens_hsa052050.62553471
106Endocytosis_Homo sapiens_hsa041440.62177228
107Cholinergic synapse_Homo sapiens_hsa047250.62121691
108Insulin signaling pathway_Homo sapiens_hsa049100.61683835
109Adherens junction_Homo sapiens_hsa045200.60949418
110B cell receptor signaling pathway_Homo sapiens_hsa046620.60200743
111Amphetamine addiction_Homo sapiens_hsa050310.59589561
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.57833300
113* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56964143
114Inositol phosphate metabolism_Homo sapiens_hsa005620.56173921
115N-Glycan biosynthesis_Homo sapiens_hsa005100.55859252
116Bladder cancer_Homo sapiens_hsa052190.55762514
117Dopaminergic synapse_Homo sapiens_hsa047280.55501542
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.54546253
119Prolactin signaling pathway_Homo sapiens_hsa049170.53037295
120Lysosome_Homo sapiens_hsa041420.52858929
121Long-term depression_Homo sapiens_hsa047300.52685778
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50466930
123Melanogenesis_Homo sapiens_hsa049160.50371981
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50369214
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.50149634
126Choline metabolism in cancer_Homo sapiens_hsa052310.50017249
127GABAergic synapse_Homo sapiens_hsa047270.49386297
128AMPK signaling pathway_Homo sapiens_hsa041520.49042798
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48747081
130MicroRNAs in cancer_Homo sapiens_hsa052060.48405131
131Maturity onset diabetes of the young_Homo sapiens_hsa049500.47750088
132* cAMP signaling pathway_Homo sapiens_hsa040240.47390423
133Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47109155
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.46298587

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »