ATP1A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.97493878
2spermatid development (GO:0007286)9.95317310
3axonemal dynein complex assembly (GO:0070286)9.82041884
4reproduction (GO:0000003)9.50883471
5motile cilium assembly (GO:0044458)9.47576447
6cilium or flagellum-dependent cell motility (GO:0001539)9.11666570
7regulation of cilium movement (GO:0003352)9.03471039
8cilium movement (GO:0003341)8.05831849
9single fertilization (GO:0007338)7.50551976
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.45984335
11negative regulation of inclusion body assembly (GO:0090084)7.39938506
12sperm capacitation (GO:0048240)7.37626549
13synaptonemal complex organization (GO:0070193)7.03513193
14male meiosis (GO:0007140)6.87940710
15synaptonemal complex assembly (GO:0007130)6.85582600
16* spermatogenesis (GO:0007283)6.74673432
17piRNA metabolic process (GO:0034587)6.73800484
18organic cation transport (GO:0015695)6.73732065
19* male gamete generation (GO:0048232)6.72189267
20microtubule depolymerization (GO:0007019)6.67362249
21* gamete generation (GO:0007276)6.17639915
22regulation of inclusion body assembly (GO:0090083)6.16043014
23* fertilization (GO:0009566)6.01970592
24calcium ion-dependent exocytosis (GO:0017156)5.73733778
25germ cell development (GO:0007281)5.50934934
26cellular process involved in reproduction in multicellular organism (GO:0022412)5.43380211
27behavioral response to nicotine (GO:0035095)5.41747298
28chromosome condensation (GO:0030261)5.35841319
29regulation of microtubule-based movement (GO:0060632)5.34235466
30response to pheromone (GO:0019236)5.29794070
31ventricular system development (GO:0021591)5.24907248
32spermatid nucleus differentiation (GO:0007289)5.18407360
33glycerol ether metabolic process (GO:0006662)5.17850908
34DNA packaging (GO:0006323)5.06721490
35cell recognition (GO:0008037)5.06477134
36* multicellular organismal reproductive process (GO:0048609)4.87341696
37microtubule severing (GO:0051013)4.79594972
38ether metabolic process (GO:0018904)4.78684252
39male meiosis I (GO:0007141)4.77355806
40chromosome organization involved in meiosis (GO:0070192)4.63338233
41seminiferous tubule development (GO:0072520)4.59675277
42sexual reproduction (GO:0019953)4.45002238
43left/right pattern formation (GO:0060972)4.42850389
44DNA methylation involved in gamete generation (GO:0043046)4.32540737
45L-fucose catabolic process (GO:0042355)4.26470680
46fucose catabolic process (GO:0019317)4.26470680
47L-fucose metabolic process (GO:0042354)4.26470680
48cellular ketone body metabolic process (GO:0046950)4.22498832
49single strand break repair (GO:0000012)4.21293873
50chaperone-mediated protein complex assembly (GO:0051131)4.16488415
51meiotic nuclear division (GO:0007126)4.11462730
52platelet dense granule organization (GO:0060155)4.08730901
53multicellular organismal development (GO:0007275)3.97493114
54DNA deamination (GO:0045006)3.86832315
55ketone body metabolic process (GO:1902224)3.80458363
56meiosis I (GO:0007127)3.80073838
57genitalia morphogenesis (GO:0035112)3.62031489
58detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.60447118
59protein polyglutamylation (GO:0018095)3.59585687
60detection of light stimulus involved in sensory perception (GO:0050962)3.51897458
61detection of light stimulus involved in visual perception (GO:0050908)3.51897458
62sequestering of actin monomers (GO:0042989)3.50560076
63water-soluble vitamin biosynthetic process (GO:0042364)3.46109235
64protein refolding (GO:0042026)3.44200223
65microtubule polymerization or depolymerization (GO:0031109)3.41529222
66protein K11-linked deubiquitination (GO:0035871)3.38474831
67regulation of spindle checkpoint (GO:0090231)3.36895813
68monoubiquitinated protein deubiquitination (GO:0035520)3.30371171
69glycolytic process (GO:0006096)3.29839305
70nephron epithelium morphogenesis (GO:0072088)3.25801939
71nephron tubule morphogenesis (GO:0072078)3.25801939
72kynurenine metabolic process (GO:0070189)3.25568488
73meiotic cell cycle (GO:0051321)3.23129396
74indole-containing compound catabolic process (GO:0042436)3.22370787
75indolalkylamine catabolic process (GO:0046218)3.22370787
76tryptophan catabolic process (GO:0006569)3.22370787
77carnitine transport (GO:0015879)3.18604861
78amino-acid betaine transport (GO:0015838)3.18604861
79nucleus organization (GO:0006997)3.18003064
80mitotic sister chromatid cohesion (GO:0007064)3.11005328
81protein localization to cilium (GO:0061512)3.09099541
82negative regulation of telomere maintenance (GO:0032205)3.08345425
83indolalkylamine metabolic process (GO:0006586)3.04116037
84regulation of action potential (GO:0098900)3.03593403
85nucleoside diphosphate phosphorylation (GO:0006165)3.02866905
86RNA localization (GO:0006403)3.02548711
87sulfation (GO:0051923)3.01405435
88centriole replication (GO:0007099)3.01156514
89polyol catabolic process (GO:0046174)3.00312489
90carnitine transmembrane transport (GO:1902603)3.00079713
91interferon-gamma secretion (GO:0072643)2.99295140
92respiratory chain complex IV assembly (GO:0008535)2.99128573
93negative regulation of mast cell activation (GO:0033004)2.97624785
94protein complex biogenesis (GO:0070271)2.97382548
95reflex (GO:0060004)2.97033789
96kidney morphogenesis (GO:0060993)2.94674794
97alditol metabolic process (GO:0019400)2.94115997
98positive regulation of macrophage activation (GO:0043032)2.91038966
99gamma-aminobutyric acid transport (GO:0015812)2.90550486
100RNA destabilization (GO:0050779)2.90181323
101nonmotile primary cilium assembly (GO:0035058)2.88873868
102neuronal action potential (GO:0019228)2.85398988
103polyamine biosynthetic process (GO:0006596)2.83653545
104mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83331563
105mitochondrial respiratory chain complex I assembly (GO:0032981)2.83331563
106NADH dehydrogenase complex assembly (GO:0010257)2.83331563
107cilium organization (GO:0044782)2.80045384
108tryptophan metabolic process (GO:0006568)2.77014545
109mitochondrial respiratory chain complex assembly (GO:0033108)2.76138550
110regulation of neurotransmitter uptake (GO:0051580)2.75700278
111GTP biosynthetic process (GO:0006183)2.75663550
112adaptation of signaling pathway (GO:0023058)2.75492028
113cytochrome complex assembly (GO:0017004)2.75408618
114microtubule-based movement (GO:0007018)2.75231271
115amine catabolic process (GO:0009310)2.73261460
116cellular biogenic amine catabolic process (GO:0042402)2.73261460
117meiotic cell cycle process (GO:1903046)2.71692721
118regulation of cilium assembly (GO:1902017)2.69443356
119cilium assembly (GO:0042384)2.68812846
120chromatin silencing (GO:0006342)2.68400671
121rRNA catabolic process (GO:0016075)2.68000104
122ubiquinone biosynthetic process (GO:0006744)2.67491658
123synapsis (GO:0007129)2.67229094
124rhodopsin mediated signaling pathway (GO:0016056)2.66098099
125neural tube formation (GO:0001841)2.65828457
126somite development (GO:0061053)2.65243068
127photoreceptor cell maintenance (GO:0045494)2.65226932
128cellular component assembly involved in morphogenesis (GO:0010927)2.65110745
129negative regulation of synaptic transmission, GABAergic (GO:0032229)2.64518626
130spinal cord motor neuron differentiation (GO:0021522)2.62932468
131cilium morphogenesis (GO:0060271)2.62655139
132lactate metabolic process (GO:0006089)2.61390739
133regulation of rhodopsin mediated signaling pathway (GO:0022400)2.61347036
134axoneme assembly (GO:0035082)2.57090895
135negative regulation of organelle assembly (GO:1902116)2.57001976
136G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56162386
137intraciliary transport (GO:0042073)2.55918454
138regulation of hexokinase activity (GO:1903299)2.55415070
139regulation of glucokinase activity (GO:0033131)2.55415070
140mitochondrion degradation (GO:0000422)2.55148249
141regulation of mesoderm development (GO:2000380)2.54312411
142primary amino compound metabolic process (GO:1901160)2.53737254
143preassembly of GPI anchor in ER membrane (GO:0016254)2.52243761
144peptidyl-glutamic acid modification (GO:0018200)2.52085620
145photoreceptor cell development (GO:0042461)2.52068144
146retinal cone cell development (GO:0046549)2.50665807
147protein-cofactor linkage (GO:0018065)2.49519364
148indole-containing compound metabolic process (GO:0042430)2.48319829
149synaptic transmission, cholinergic (GO:0007271)2.48130953
150ubiquinone metabolic process (GO:0006743)2.47178444
151dopamine transport (GO:0015872)2.46934708
152UTP biosynthetic process (GO:0006228)2.46312968
153positive regulation of glycolytic process (GO:0045821)2.45616541
154alanine transport (GO:0032328)2.45271851
155peristalsis (GO:0030432)2.44095195
156cornea development in camera-type eye (GO:0061303)2.43862996
157renal tubule morphogenesis (GO:0061333)2.42405953
158mannosylation (GO:0097502)2.41409774
159auditory receptor cell stereocilium organization (GO:0060088)2.41116019
160rRNA methylation (GO:0031167)2.39746068
161cAMP catabolic process (GO:0006198)2.38422544
162reciprocal DNA recombination (GO:0035825)2.38330995
163* sperm motility (GO:0030317)13.8772589
164fusion of sperm to egg plasma membrane (GO:0007342)13.4710166
165cell wall macromolecule metabolic process (GO:0044036)12.9176392
166cell wall macromolecule catabolic process (GO:0016998)12.9176392
167acrosome reaction (GO:0007340)12.5445859
168sperm-egg recognition (GO:0035036)11.6701506
169acrosome assembly (GO:0001675)11.4333864
170multicellular organism reproduction (GO:0032504)10.9542096
171binding of sperm to zona pellucida (GO:0007339)10.6098401
172cell-cell recognition (GO:0009988)10.4450235
173plasma membrane fusion (GO:0045026)10.2676033

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.20328869
2EZH2_22144423_ChIP-Seq_EOC_Human4.26806967
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.91809806
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.28088591
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.93747845
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.84054803
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.75461403
8GBX2_23144817_ChIP-Seq_PC3_Human2.63449105
9VDR_22108803_ChIP-Seq_LS180_Human2.54745118
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40750504
11CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.27429035
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.18624545
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17532630
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14403205
15IGF1R_20145208_ChIP-Seq_DFB_Human2.13782203
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05031458
17FUS_26573619_Chip-Seq_HEK293_Human2.03449893
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01501222
19ZNF274_21170338_ChIP-Seq_K562_Hela2.00288769
20P300_19829295_ChIP-Seq_ESCs_Human1.99139997
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93464182
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.90566841
23ER_23166858_ChIP-Seq_MCF-7_Human1.90063896
24KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.79344608
25ELK4_26923725_Chip-Seq_MESODERM_Mouse1.77304650
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76984585
27EWS_26573619_Chip-Seq_HEK293_Human1.73554346
28TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.71465576
29* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70903457
30MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.70498067
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70008711
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.68122375
33* STAT1_17558387_ChIP-Seq_HELA_Human1.66183609
34SOX2_22085726_ChIP-Seq_NPCs_Mouse1.65845519
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62349324
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59038686
37WDR5_24793694_ChIP-Seq_LNCAP_Human1.56286139
38GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.56174883
39GATA3_21867929_ChIP-Seq_CD8_Mouse1.54161540
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52063891
41AR_25329375_ChIP-Seq_VCAP_Human1.51478308
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49700810
43TP53_22573176_ChIP-Seq_HFKS_Human1.49123957
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48145272
45* STAT3_23295773_ChIP-Seq_U87_Human1.47747092
46RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.47526879
47KDM2B_26808549_Chip-Seq_REH_Human1.46835237
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46050075
49CBP_20019798_ChIP-Seq_JUKART_Human1.46050075
50FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.43875503
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43788141
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41686633
53TCF4_23295773_ChIP-Seq_U87_Human1.41584438
54PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.40955571
55* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40897670
56* FOXA1_25329375_ChIP-Seq_VCAP_Human1.40897670
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.40748586
58* NANOG_19829295_ChIP-Seq_ESCs_Human1.40325686
59* SOX2_19829295_ChIP-Seq_ESCs_Human1.40325686
60SMAD4_21799915_ChIP-Seq_A2780_Human1.37998486
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36838441
62P53_21459846_ChIP-Seq_SAOS-2_Human1.36507262
63* TAL1_26923725_Chip-Seq_HPCs_Mouse1.36460155
64BCAT_22108803_ChIP-Seq_LS180_Human1.36106726
65LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.36061190
66KAP1_22055183_ChIP-Seq_ESCs_Mouse1.35981090
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.34801384
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.34231111
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.34208127
70IRF1_19129219_ChIP-ChIP_H3396_Human1.34136777
71REST_21632747_ChIP-Seq_MESCs_Mouse1.32959378
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30663943
73SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29585637
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28978466
75GATA3_21867929_ChIP-Seq_TH1_Mouse1.28307557
76MYC_18940864_ChIP-ChIP_HL60_Human1.27998072
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27809603
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27628232
79NCOR_22424771_ChIP-Seq_293T_Human1.26786606
80AR_21572438_ChIP-Seq_LNCaP_Human1.26051209
81TCF4_22108803_ChIP-Seq_LS180_Human1.25864739
82HOXB7_26014856_ChIP-Seq_BT474_Human1.25727042
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25121111
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24484472
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24205336
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.23965558
87RAD21_21589869_ChIP-Seq_MESCs_Mouse1.23652424
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23589020
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23389410
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23309884
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22768101
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.22350758
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22191406
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.20793990
95CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19636725
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19011722
97RNF2_27304074_Chip-Seq_NSC_Mouse1.18995286
98CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18982510
99RUNX2_22187159_ChIP-Seq_PCA_Human1.18615832
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.17919320
101GABP_17652178_ChIP-ChIP_JURKAT_Human1.17250466
102* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17163074
103AR_20517297_ChIP-Seq_VCAP_Human1.16679282
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16332152
105SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15754780
106PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15693816
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.15455762
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15409482
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15409482
110SPI1_26923725_Chip-Seq_HPCs_Mouse1.14741488
111* GF1_26923725_Chip-Seq_HPCs_Mouse1.14103577
112AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14054309
113SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14051631
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12414660
115ERA_21632823_ChIP-Seq_H3396_Human1.12320384
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12058158
117* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11667076
118RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10121721
119MYC_19829295_ChIP-Seq_ESCs_Human1.09832337
120ERG_20517297_ChIP-Seq_VCAP_Human1.09614397
121* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09504269
122TAF15_26573619_Chip-Seq_HEK293_Human1.08729032
123RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08563492
124SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08088024
125TAF2_19829295_ChIP-Seq_ESCs_Human1.07995568
126MYC_27129775_Chip-Seq_CORNEA_Mouse1.07887368
127PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07049903
128EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06751893
129ESET_19884257_ChIP-Seq_ESCs_Mouse1.04488974
130GATA1_19941827_ChIP-Seq_MEL86_Mouse1.04407230
131FOXH1_21741376_ChIP-Seq_EPCs_Human1.04141867
132RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03890277
133NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03828443
134YY1_22570637_ChIP-Seq_MALME-3M_Human1.02707489
135JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.02682579
136RARA_24833708_ChIP-Seq_LIVER_Mouse1.01760267
137EST1_17652178_ChIP-ChIP_JURKAT_Human1.01422968
138CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00090720
139CTCF_20526341_ChIP-Seq_ESCs_Human0.98618799
140TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98567497
141* CRX_20693478_ChIP-Seq_RETINA_Mouse0.97756927
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97744250
143* ETV1_20927104_ChIP-Seq_GIST48_Human0.96414540
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96406875
145EZH2_27304074_Chip-Seq_ESCs_Mouse0.96397757
146* TET1_21451524_ChIP-Seq_MESCs_Mouse0.96378970
147SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96211263
148* P53_22387025_ChIP-Seq_ESCs_Mouse0.95732029
149SOX11_22085726_ChIP-Seq_ESNs_Mouse0.95401964
150* NANOG_18555785_Chip-Seq_ESCs_Mouse0.95322106
151OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95256930
152DROSHA_22980978_ChIP-Seq_HELA_Human0.94897568
153LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93593231
154ELF1_20517297_ChIP-Seq_JURKAT_Human0.93567042
155NFYB_21822215_ChIP-Seq_K562_Human0.93087695
156* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92886328
157KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92149148
158FLI1_21867929_ChIP-Seq_CD8_Mouse0.92087128
159NANOG_20526341_ChIP-Seq_ESCs_Human0.89418988
160* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88973792
161SOX9_26525672_Chip-Seq_HEART_Mouse0.88339088
162STAT3_18555785_ChIP-Seq_MESCs_Mouse0.87517239
163MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87231547
164BCOR_27268052_Chip-Seq_Bcells_Human0.86910110
165SOX2_21211035_ChIP-Seq_LN229_Human0.86804350
166* OCT4_18555785_Chip-Seq_ESCs_Mouse0.86796581
167TBL1_22424771_ChIP-Seq_293T_Human0.86518150
168SMAD4_21741376_ChIP-Seq_EPCs_Human0.86093552

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.07236273
2MP0001929_abnormal_gametogenesis5.49074136
3MP0008877_abnormal_DNA_methylation3.85332654
4MP0002161_abnormal_fertility/fecundity3.31773650
5MP0002210_abnormal_sex_determination3.29141198
6MP0005670_abnormal_white_adipose3.23024476
7MP0003195_calcinosis3.10103684
8MP0001145_abnormal_male_reproductive2.79595284
9MP0002837_dystrophic_cardiac_calcinosis2.56080646
10MP0000653_abnormal_sex_gland2.41059951
11MP0002653_abnormal_ependyma_morphology2.24219368
12MP0001485_abnormal_pinna_reflex2.09492210
13MP0008872_abnormal_physiological_respon2.07328831
14MP0001986_abnormal_taste_sensitivity2.07244237
15MP0002638_abnormal_pupillary_reflex2.05315460
16MP0005410_abnormal_fertilization16.6607851
17MP0004142_abnormal_muscle_tone1.97177007
18MP0002876_abnormal_thyroid_physiology1.85646756
19MP0009745_abnormal_behavioral_response1.84927126
20MP0006072_abnormal_retinal_apoptosis1.84774821
21MP0004147_increased_porphyrin_level1.83803000
22MP0005645_abnormal_hypothalamus_physiol1.83457408
23MP0006292_abnormal_olfactory_placode1.80283861
24MP0001486_abnormal_startle_reflex1.74097854
25MP0004885_abnormal_endolymph1.73889063
26MP0003136_yellow_coat_color1.73591816
27MP0002272_abnormal_nervous_system1.66346258
28MP0005646_abnormal_pituitary_gland1.65144741
29MP0003787_abnormal_imprinting1.63746782
30MP0000372_irregular_coat_pigmentation1.62578185
31MP0003646_muscle_fatigue1.54971817
32MP0001501_abnormal_sleep_pattern1.52195902
33MP0002735_abnormal_chemical_nociception1.51539501
34MP0005623_abnormal_meninges_morphology1.48461654
35MP0002160_abnormal_reproductive_system1.48224724
36MP0004233_abnormal_muscle_weight1.47434653
37MP0005379_endocrine/exocrine_gland_phen1.43649238
38MP0000427_abnormal_hair_cycle1.40064961
39MP0002938_white_spotting1.37956446
40MP0005084_abnormal_gallbladder_morpholo1.30816333
41MP0002572_abnormal_emotion/affect_behav1.29527475
42MP0002138_abnormal_hepatobiliary_system1.24384568
43MP0000631_abnormal_neuroendocrine_gland1.24365303
44MP0003283_abnormal_digestive_organ1.23223066
45MP0006276_abnormal_autonomic_nervous1.22854640
46MP0003880_abnormal_central_pattern1.22658134
47MP0002282_abnormal_trachea_morphology1.22349510
48MP0003718_maternal_effect1.21135875
49MP0002733_abnormal_thermal_nociception1.18674650
50MP0002557_abnormal_social/conspecific_i1.17731865
51MP0001765_abnormal_ion_homeostasis1.17310325
52MP0002064_seizures1.15605124
53MP0002067_abnormal_sensory_capabilities1.15507333
54MP0001970_abnormal_pain_threshold1.14933374
55MP0001529_abnormal_vocalization1.14362094
56MP0002163_abnormal_gland_morphology1.09125461
57MP0005075_abnormal_melanosome_morpholog1.04576185
58MP0001905_abnormal_dopamine_level1.03108695
59MP0005423_abnormal_somatic_nervous1.02404484
60MP0000026_abnormal_inner_ear0.98945640
61MP0005386_behavior/neurological_phenoty0.98722196
62MP0004924_abnormal_behavior0.98722196
63MP0005174_abnormal_tail_pigmentation0.97864865
64MP0001984_abnormal_olfaction0.97486660
65MP0002734_abnormal_mechanical_nocicepti0.97308195
66MP0003137_abnormal_impulse_conducting0.96360081
67MP0005195_abnormal_posterior_eye0.95406027
68MP0003635_abnormal_synaptic_transmissio0.95351149
69MP0002063_abnormal_learning/memory/cond0.91783614
70MP0001963_abnormal_hearing_physiology0.91284172
71MP0001440_abnormal_grooming_behavior0.89636993
72MP0005167_abnormal_blood-brain_barrier0.87169298
73MP0000230_abnormal_systemic_arterial0.86974760
74MP0005647_abnormal_sex_gland0.86509192
75MP0010386_abnormal_urinary_bladder0.83672799
76MP0001919_abnormal_reproductive_system0.82272683
77MP0008995_early_reproductive_senescence0.82097109
78MP0005332_abnormal_amino_acid0.81349083
79MP0002254_reproductive_system_inflammat0.81154896
80MP0003119_abnormal_digestive_system0.80585978
81MP0002234_abnormal_pharynx_morphology0.80357191
82MP0002752_abnormal_somatic_nervous0.80280202
83MP0004215_abnormal_myocardial_fiber0.79438039
84MP0003115_abnormal_respiratory_system0.78158991
85MP0008775_abnormal_heart_ventricle0.77955216
86MP0002095_abnormal_skin_pigmentation0.76481697
87MP0009046_muscle_twitch0.75365831
88MP0005671_abnormal_response_to0.75133856
89MP0005389_reproductive_system_phenotype0.73965661
90MP0003121_genomic_imprinting0.73888058
91MP0005666_abnormal_adipose_tissue0.73316206
92MP0008058_abnormal_DNA_repair0.72979133
93MP0001502_abnormal_circadian_rhythm0.71779986
94MP0003878_abnormal_ear_physiology0.70311340
95MP0005377_hearing/vestibular/ear_phenot0.70311340
96MP0005636_abnormal_mineral_homeostasis0.63865424
97MP0003011_delayed_dark_adaptation0.61596851
98MP0003329_amyloid_beta_deposits0.55743277
99MP0004036_abnormal_muscle_relaxation0.54800549
100MP0001764_abnormal_homeostasis0.52691507
101MP0001324_abnormal_eye_pigmentation0.50871695
102MP0002269_muscular_atrophy0.50123158
103MP0000358_abnormal_cell_content/0.47857745
104MP0000569_abnormal_digit_pigmentation0.47853529
105MP0003699_abnormal_female_reproductive0.45701204
106MP0009115_abnormal_fat_cell0.44172406
107MP0001293_anophthalmia0.43944242
108MP0009278_abnormal_bone_marrow0.43671341
109MP0001545_abnormal_hematopoietic_system0.42397911
110MP0005397_hematopoietic_system_phenotyp0.42397911
111MP0002736_abnormal_nociception_after0.42101423
112MP0000534_abnormal_ureter_morphology0.41867960
113MP0003950_abnormal_plasma_membrane0.40802153
114MP0002928_abnormal_bile_duct0.40018042
115MP0006036_abnormal_mitochondrial_physio0.38460002
116MP0005253_abnormal_eye_physiology0.38267806
117MP0010094_abnormal_chromosome_stability0.37883360
118MP0002971_abnormal_brown_adipose0.37073113
119MP0005551_abnormal_eye_electrophysiolog0.36159800
120MP0003942_abnormal_urinary_system0.30697428
121MP0005375_adipose_tissue_phenotype0.29583485
122MP0005391_vision/eye_phenotype0.29364058
123MP0004133_heterotaxia0.28983531
124MP0003633_abnormal_nervous_system0.28443443
125MP0000604_amyloidosis0.27992875
126MP0003879_abnormal_hair_cell0.27901010
127MP0004811_abnormal_neuron_physiology0.27501314
128MP0003111_abnormal_nucleus_morphology0.27443040
129MP0002139_abnormal_hepatobiliary_system0.25968538
130MP0002295_abnormal_pulmonary_circulatio0.25469288
131MP0003948_abnormal_gas_homeostasis0.25302089
132MP0008961_abnormal_basal_metabolism0.25162276
133MP0001730_embryonic_growth_arrest0.24836207
134MP0000751_myopathy0.23402556
135MP0003861_abnormal_nervous_system0.23213220
136MP0004019_abnormal_vitamin_homeostasis0.23065518
137MP0001968_abnormal_touch/_nociception0.22526836
138MP0001119_abnormal_female_reproductive0.22323950
139MP0003631_nervous_system_phenotype0.21722206
140MP0002102_abnormal_ear_morphology0.21447015
141MP0002152_abnormal_brain_morphology0.21310753
142MP0002169_no_abnormal_phenotype0.21280813
143MP0001727_abnormal_embryo_implantation0.21158588
144MP0006035_abnormal_mitochondrial_morpho0.21095946
145MP0002873_normal_phenotype0.21024113
146MP0001849_ear_inflammation0.20821530
147MP0003786_premature_aging0.20536972
148MP0004130_abnormal_muscle_cell0.20003951
149MP0004742_abnormal_vestibular_system0.18998957
150MP0004145_abnormal_muscle_electrophysio0.18762728
151MP0003959_abnormal_lean_body0.18434464
152MP0001661_extended_life_span0.17642503
153MP0004270_analgesia0.16370647
154MP0002092_abnormal_eye_morphology0.15717005
155MP0002118_abnormal_lipid_homeostasis0.15594071
156MP0005365_abnormal_bile_salt0.14692750
157MP0004043_abnormal_pH_regulation0.14448504
158MP0008569_lethality_at_weaning0.14268566
159MP0005319_abnormal_enzyme/_coenzyme0.14234309
160MP0002909_abnormal_adrenal_gland0.13961997
161MP0000001_mammalian_phenotype0.12999100
162MP0008875_abnormal_xenobiotic_pharmacok0.12926198
163MP0010329_abnormal_lipoprotein_level0.12811048
164MP0002229_neurodegeneration0.12789515
165MP0003045_fibrosis0.12284962
166MP0002084_abnormal_developmental_patter0.12271355
167MP0010307_abnormal_tumor_latency0.12135452
168MP0002693_abnormal_pancreas_physiology0.12108614

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.32803981
2Abnormal respiratory epithelium morphology (HP:0012253)9.32803981
3Abnormal respiratory motile cilium physiology (HP:0012261)9.23382401
4Rhinitis (HP:0012384)7.32262866
5Abnormal ciliary motility (HP:0012262)7.31500933
6Chronic bronchitis (HP:0004469)7.20508092
7Infertility (HP:0000789)7.05694625
8Nasal polyposis (HP:0100582)6.39741677
9Abnormality of the nasal mucosa (HP:0000433)5.27253014
10Male infertility (HP:0003251)5.12537104
11Pancreatic cysts (HP:0001737)4.66704172
12Bronchitis (HP:0012387)4.59319817
13Bronchiectasis (HP:0002110)4.36581301
14Pancreatic fibrosis (HP:0100732)4.28809208
15Nephronophthisis (HP:0000090)4.12540179
16Congenital stationary night blindness (HP:0007642)4.12400790
17True hermaphroditism (HP:0010459)4.11678247
18Abnormal spermatogenesis (HP:0008669)3.79885327
19Attenuation of retinal blood vessels (HP:0007843)3.40628755
20Recurrent sinusitis (HP:0011108)3.32134834
21Recurrent otitis media (HP:0000403)3.29915619
22Type II lissencephaly (HP:0007260)3.26629290
23Abnormality of the renal medulla (HP:0100957)3.09785652
24Abolished electroretinogram (ERG) (HP:0000550)3.03372885
25Chronic hepatic failure (HP:0100626)3.02558823
26Hyperventilation (HP:0002883)3.00532132
27Abnormal rod and cone electroretinograms (HP:0008323)2.96690194
28Pendular nystagmus (HP:0012043)2.92725881
29Large for gestational age (HP:0001520)2.92189375
30Recurrent bronchitis (HP:0002837)2.85194301
31Tubulointerstitial nephritis (HP:0001970)2.83773778
32Impulsivity (HP:0100710)2.79294765
33Sclerocornea (HP:0000647)2.62585720
34Tubular atrophy (HP:0000092)2.59491756
35Cholecystitis (HP:0001082)2.58149120
36Abnormal gallbladder physiology (HP:0012438)2.58149120
37Increased corneal curvature (HP:0100692)2.54739802
38Keratoconus (HP:0000563)2.54739802
39Renal cortical cysts (HP:0000803)2.51538416
40Molar tooth sign on MRI (HP:0002419)2.51054005
41Abnormality of midbrain morphology (HP:0002418)2.51054005
42Inability to walk (HP:0002540)2.49084053
43Tubulointerstitial abnormality (HP:0001969)2.42967614
44Congenital, generalized hypertrichosis (HP:0004540)2.41973312
45Abnormality of macular pigmentation (HP:0008002)2.36835133
46Gonadotropin excess (HP:0000837)2.33207553
47Abnormality of alanine metabolism (HP:0010916)2.32418069
48Hyperalaninemia (HP:0003348)2.32418069
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32418069
50Bony spicule pigmentary retinopathy (HP:0007737)2.31999672
51Progressive cerebellar ataxia (HP:0002073)2.31683482
52Azoospermia (HP:0000027)2.29983021
53Medial flaring of the eyebrow (HP:0010747)2.28197708
54Anencephaly (HP:0002323)2.26963450
55Furrowed tongue (HP:0000221)2.26848873
56Dyschromatopsia (HP:0007641)2.21880580
57Concave nail (HP:0001598)2.20946133
58Genetic anticipation (HP:0003743)2.17708903
59Nephrogenic diabetes insipidus (HP:0009806)2.14787334
60Chorioretinal atrophy (HP:0000533)2.13948719
61Aplasia/Hypoplasia of the tongue (HP:0010295)2.12305358
62Broad-based gait (HP:0002136)2.09478590
63Lissencephaly (HP:0001339)2.09466863
64Patellar aplasia (HP:0006443)2.09102222
65Male pseudohermaphroditism (HP:0000037)2.08370971
66Optic nerve hypoplasia (HP:0000609)2.07844105
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07715273
68Gaze-evoked nystagmus (HP:0000640)2.07062178
69Aplasia/Hypoplasia of the fovea (HP:0008060)2.05815957
70Hypoplasia of the fovea (HP:0007750)2.05815957
71Polyuria (HP:0000103)2.04678299
72Decreased circulating renin level (HP:0003351)2.04512587
73Choroideremia (HP:0001139)2.04026578
74Severe muscular hypotonia (HP:0006829)2.01958939
75Progressive inability to walk (HP:0002505)2.01797006
76Genital tract atresia (HP:0001827)2.01642788
77Spastic tetraparesis (HP:0001285)2.01594218
78Aplasia/Hypoplasia of the patella (HP:0006498)2.01391532
79Severe visual impairment (HP:0001141)2.01222691
80Dynein arm defect of respiratory motile cilia (HP:0012255)13.6427955
81Absent/shortened dynein arms (HP:0200106)13.6427955
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8807173
83Mitochondrial inheritance (HP:0001427)1.97020986
84Aplasia/Hypoplasia of the tibia (HP:0005772)1.96709077
85Tubulointerstitial fibrosis (HP:0005576)1.96336900
86Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96312711
87Vaginal atresia (HP:0000148)1.96095484
88Abnormality of the pons (HP:0007361)1.94832467
89Decreased central vision (HP:0007663)1.94721429
90Congenital sensorineural hearing impairment (HP:0008527)1.92452807
91Increased CSF lactate (HP:0002490)1.90348876
92Acute necrotizing encephalopathy (HP:0006965)1.90098577
93Hypoplasia of the pons (HP:0012110)1.89506387
94Optic disc pallor (HP:0000543)1.84311854
95Heterotopia (HP:0002282)1.82629582
96Birth length less than 3rd percentile (HP:0003561)1.81783748
97Hemorrhage of the eye (HP:0011885)1.80219097
983-Methylglutaconic aciduria (HP:0003535)1.79204897
99Abnormality of the fovea (HP:0000493)1.75481219
100Acute encephalopathy (HP:0006846)1.75329475
101Stage 5 chronic kidney disease (HP:0003774)1.74653890
102Abnormal drinking behavior (HP:0030082)1.73988390
103Polydipsia (HP:0001959)1.73988390
104Postaxial foot polydactyly (HP:0001830)1.73833527
105Protruding tongue (HP:0010808)1.73553011
106Intestinal atresia (HP:0011100)1.72156042
107Progressive macrocephaly (HP:0004481)1.71902543
108Aplasia/hypoplasia of the uterus (HP:0008684)1.71582336
109Chronic otitis media (HP:0000389)1.70584374
110Tachypnea (HP:0002789)1.70381436
111Abnormality of the labia minora (HP:0012880)1.69779727
112Pachygyria (HP:0001302)1.69686899
113Hypomagnesemia (HP:0002917)1.69421229
114Abnormal biliary tract physiology (HP:0012439)1.68441526
115Bile duct proliferation (HP:0001408)1.68441526
116Hyperglycinuria (HP:0003108)1.66582203
117Gastrointestinal atresia (HP:0002589)1.66352120
118Congenital hepatic fibrosis (HP:0002612)1.64613267
119Neurofibrillary tangles (HP:0002185)1.62874444
120Abnormality of renal excretion (HP:0011036)1.62142089
121Bell-shaped thorax (HP:0001591)1.61596483
122Abnormality of the renal cortex (HP:0011035)1.60526326
123Asymmetric septal hypertrophy (HP:0001670)1.60232575
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.59212333
125Decreased electroretinogram (ERG) amplitude (HP:0000654)1.56692829
126Congenital malformation of the right heart (HP:0011723)1.56612392
127Double outlet right ventricle (HP:0001719)1.56612392
128Short ribs (HP:0000773)1.55739541
129Oculomotor apraxia (HP:0000657)1.49742291
130Bundle branch block (HP:0011710)1.44521765
131Abnormality of permanent molar morphology (HP:0011071)1.42910642
132Abnormality of the dental root (HP:0006486)1.42910642
133Taurodontia (HP:0000679)1.42910642
134Aplasia/Hypoplasia of the lens (HP:0008063)1.42094340
135Abnormality of dentin (HP:0010299)1.39739155
136Abnormality of the lower motor neuron (HP:0002366)1.38868414
137Fibular hypoplasia (HP:0003038)1.38373761
138Renal dysplasia (HP:0000110)1.37184755
139Postaxial hand polydactyly (HP:0001162)1.36916266
140Cerebral inclusion bodies (HP:0100314)1.36288946
141Abnormal urine output (HP:0012590)1.36159602
142Deformed sella turcica (HP:0002681)1.35231731
143Hemiparesis (HP:0001269)1.33596871
144Abnormality of the dental pulp (HP:0006479)1.32880447
145Easy fatigability (HP:0003388)1.32530440
146Exercise-induced myalgia (HP:0003738)1.32126230
147Abnormality of molar (HP:0011077)1.31817555
148Abnormality of molar morphology (HP:0011070)1.31817555
149Cystic liver disease (HP:0006706)1.31312981
150Hypercholesterolemia (HP:0003124)1.29930040
151Myoglobinuria (HP:0002913)1.28762758
152Facial cleft (HP:0002006)1.28753650
153Constricted visual fields (HP:0001133)1.27526685
154Chronic sinusitis (HP:0011109)1.24763037
155Absent epiphyses (HP:0010577)1.24252572
156Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.24252572
157Sensory axonal neuropathy (HP:0003390)1.22825421
158Truncal obesity (HP:0001956)1.21833680
159Abnormality of the neuromuscular junction (HP:0003398)1.21377819
160Fatigable weakness (HP:0003473)1.21377819
161Loss of speech (HP:0002371)1.20939758
162Cerebellar dysplasia (HP:0007033)1.19616823
163Amyotrophic lateral sclerosis (HP:0007354)1.18666161
164Broad distal phalanx of finger (HP:0009836)1.18153827
165Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.17190718
166Absent frontal sinuses (HP:0002688)1.16993403
167Nephropathy (HP:0000112)1.15012984
168Congenital primary aphakia (HP:0007707)1.14531429
169Gait imbalance (HP:0002141)1.14354639
170Neoplasm of the heart (HP:0100544)1.14151977
171Rhabdomyolysis (HP:0003201)1.13790167
172Abnormality of saccadic eye movements (HP:0000570)1.13777547

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.03704611
2PDK48.03704611
3TESK16.49229740
4PRKD35.49648569
5FRK5.26036455
6PDK25.20523445
7ICK4.69248497
8BMPR1B3.84007415
9ADRBK23.42983198
10ACVR1B2.90373452
11MAP4K22.77260783
12GRK12.68218246
13INSRR2.63940488
14NUAK12.49156343
15PTK2B2.24553847
16ZAK2.22495429
17WNK42.06058833
18PNCK1.97156746
19STK391.94577994
20TLK11.93146028
21STK381.84341327
22CASK1.77810744
23MAPK131.77426899
24DYRK1B1.66446341
25TXK1.64943062
26DAPK21.62231891
27TAOK31.58975588
28NEK21.47941610
29OXSR11.46453995
30TGFBR11.43179472
31TNIK1.39180142
32MAP3K41.37926593
33PLK21.28818054
34MKNK21.23918421
35PDK11.20157231
36DYRK21.17775405
37ADRBK11.13509940
38TRIM281.11969855
39PAK31.04219325
40PHKG11.04029721
41PHKG21.04029721
42NME11.03156731
43NTRK30.98820685
44GRK70.95409535
45TIE10.95227332
46PRKCE0.94625540
47VRK10.93928130
48TYRO30.90735306
49DYRK30.88101244
50MAPK150.86391604
51CAMKK20.84462576
52BCKDK0.83602144
53MAP2K70.81753867
54WNK10.79354529
55IKBKB0.77933659
56SIK20.77483682
57MST40.76789246
58PDPK10.76341662
59IRAK10.74329551
60FGFR20.74112466
61MARK10.73912138
62OBSCN0.72826323
63RIPK40.68962756
64MAPKAPK30.68315458
65PRKCI0.67332728
66EEF2K0.66613070
67PASK0.65846713
68CAMK1G0.64025536
69KIT0.61198177
70TESK20.60036055
71MAP2K60.59034028
72CCNB10.58711956
73EPHA30.56833750
74PIK3CA0.56612397
75STK30.56480357
76TTK0.56454022
77TEC0.56065729
78CSNK1G20.55540673
79CHEK20.54339915
80LMTK20.52740471
81CSNK1G10.51388372
82PINK10.51263111
83GRK50.50753781
84PLK30.50055042
85PRKACA0.48782053
86MKNK10.47800260
87CAMK10.47438006
88ERBB30.47024873
89BCR0.45392320
90PRKAA20.43400298
91PAK10.42833253
92NLK0.42680210
93IRAK20.42636415
94CSNK1G30.42369005
95RPS6KA50.41653080
96NTRK20.40478386
97VRK20.39631418
98CSNK1A10.38656938
99STK38L0.38052594
100MUSK0.37724969
101CHUK0.37641640
102CHEK10.36736920
103STK160.35563973
104PRKCG0.34137318
105PAK20.33875980
106MAP2K10.32813340
107ITK0.31285815
108MAP3K100.31261022
109PIK3CG0.30356033
110PRKCH0.29703488
111MTOR0.28603491
112EIF2AK30.28192330
113MARK20.27040436
114PAK40.26841605
115SYK0.25804082
116CSNK1A1L0.25739170
117ATM0.25722345
118CAMKK10.21954949
119MAPKAPK50.21900527
120NEK60.20297489
121PRKAA10.20251299
122ATR0.20011981
123PLK40.18207521
124PRKCZ0.17970763
125WEE10.16145379
126RPS6KB10.14442768
127CDK150.13872954
128PRKCQ0.13021474
129BRSK20.12211736
130CDK180.11287231
131PRKG20.10514853
132CDK11A0.10106875
133PLK10.09318578
134CDC70.09063285
135RPS6KA10.07963469
136GSK3B0.07195515
137CDK60.06698697
138CDK140.06659630
139BRSK10.06620180
140CSNK2A10.05842862
141CDK120.05474260
142CSNK1D0.04848836
143STK110.04579928
144MARK30.04355214
145STK100.03784609
146BRAF0.03523496
147CSF1R0.03246977
148PRKACG0.03192008
149PRKG10.03138602
150CAMK2A0.02761366
151CDK20.02360828
152PKN10.02182091
153CDK10.02052361
154MAPK80.01878466
155PRKCD0.01822200
156TRIB30.01735574
157PIM10.01467355
158PRKCB0.01350792
159CSNK2A20.01119784
160PRKCA0.00260677
161CLK10.00122840
162EPHB1-0.0307132
163MAP3K5-0.0303071
164RIPK1-0.0296005
165PDGFRB-0.0235965
166PRKACB-0.0231032
167MAP3K1-0.0219926
168WNK3-0.0180992
169RPS6KA3-0.0172948
170EGFR-0.0107132
171CDK4-0.0063804
172PAK6-0.0027019

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.11236486
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.80995164
3Pyruvate metabolism_Homo sapiens_hsa006203.59074041
4Vitamin B6 metabolism_Homo sapiens_hsa007503.54811295
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.30097439
6Linoleic acid metabolism_Homo sapiens_hsa005913.18543102
7Phototransduction_Homo sapiens_hsa047442.92937154
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.91290848
9Propanoate metabolism_Homo sapiens_hsa006402.79745727
10Glucagon signaling pathway_Homo sapiens_hsa049222.72133420
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.69541350
12Nitrogen metabolism_Homo sapiens_hsa009102.62156447
13Butanoate metabolism_Homo sapiens_hsa006502.41523029
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.38780004
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28216128
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.23870382
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.22639026
18Basal transcription factors_Homo sapiens_hsa030222.19309825
19Glycerolipid metabolism_Homo sapiens_hsa005612.18947092
20PPAR signaling pathway_Homo sapiens_hsa033202.16358659
21Oxidative phosphorylation_Homo sapiens_hsa001902.10298462
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08162682
23Selenocompound metabolism_Homo sapiens_hsa004502.05417737
24Nicotine addiction_Homo sapiens_hsa050332.04942669
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.03626922
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.00385727
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.95163254
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.87920298
29Fructose and mannose metabolism_Homo sapiens_hsa000511.85040710
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.80883607
31Oocyte meiosis_Homo sapiens_hsa041141.72022564
32Homologous recombination_Homo sapiens_hsa034401.67382086
33Fatty acid metabolism_Homo sapiens_hsa012121.65335749
34Fatty acid degradation_Homo sapiens_hsa000711.64671558
35Olfactory transduction_Homo sapiens_hsa047401.64404529
36Fat digestion and absorption_Homo sapiens_hsa049751.63570369
37Pentose phosphate pathway_Homo sapiens_hsa000301.61348835
38Dorso-ventral axis formation_Homo sapiens_hsa043201.61219590
39Tryptophan metabolism_Homo sapiens_hsa003801.60863553
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59518278
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.59241965
42Protein export_Homo sapiens_hsa030601.59134419
43Amphetamine addiction_Homo sapiens_hsa050311.56293064
44Caffeine metabolism_Homo sapiens_hsa002321.53555406
45Parkinsons disease_Homo sapiens_hsa050121.52885780
46Carbon metabolism_Homo sapiens_hsa012001.51234973
47Ether lipid metabolism_Homo sapiens_hsa005651.50518171
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.50117601
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39128924
50RNA polymerase_Homo sapiens_hsa030201.37709930
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.34149197
52Morphine addiction_Homo sapiens_hsa050321.30067416
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22636706
54Antigen processing and presentation_Homo sapiens_hsa046121.21944548
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.21036728
56Renin secretion_Homo sapiens_hsa049241.19604934
57Fanconi anemia pathway_Homo sapiens_hsa034601.17364189
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16697386
59Regulation of autophagy_Homo sapiens_hsa041401.16148597
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12741500
61RNA degradation_Homo sapiens_hsa030181.09915915
62Primary immunodeficiency_Homo sapiens_hsa053401.09535821
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08938045
64Steroid hormone biosynthesis_Homo sapiens_hsa001401.08434878
65Purine metabolism_Homo sapiens_hsa002301.06113915
66One carbon pool by folate_Homo sapiens_hsa006701.06081530
67Hedgehog signaling pathway_Homo sapiens_hsa043401.04775826
68mRNA surveillance pathway_Homo sapiens_hsa030151.04486420
69Primary bile acid biosynthesis_Homo sapiens_hsa001201.03394596
70Glutathione metabolism_Homo sapiens_hsa004801.03291021
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02566263
72Adipocytokine signaling pathway_Homo sapiens_hsa049201.01288320
73Huntingtons disease_Homo sapiens_hsa050160.99878939
74Collecting duct acid secretion_Homo sapiens_hsa049660.98032992
75beta-Alanine metabolism_Homo sapiens_hsa004100.96456805
76* Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95354527
77Biosynthesis of amino acids_Homo sapiens_hsa012300.95292672
78Alzheimers disease_Homo sapiens_hsa050100.93856174
79GABAergic synapse_Homo sapiens_hsa047270.92147704
80Asthma_Homo sapiens_hsa053100.90626230
81Serotonergic synapse_Homo sapiens_hsa047260.89696553
82Arachidonic acid metabolism_Homo sapiens_hsa005900.88979679
83Chemical carcinogenesis_Homo sapiens_hsa052040.88004033
84RNA transport_Homo sapiens_hsa030130.86360318
85Histidine metabolism_Homo sapiens_hsa003400.86350757
86Estrogen signaling pathway_Homo sapiens_hsa049150.85014623
87Type I diabetes mellitus_Homo sapiens_hsa049400.84616262
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82737988
89Long-term potentiation_Homo sapiens_hsa047200.79118502
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79108576
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76399877
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.74062565
93Ovarian steroidogenesis_Homo sapiens_hsa049130.73475375
94Legionellosis_Homo sapiens_hsa051340.71270034
95Renin-angiotensin system_Homo sapiens_hsa046140.67209747
96Graft-versus-host disease_Homo sapiens_hsa053320.65846217
97Proteasome_Homo sapiens_hsa030500.64239465
98Allograft rejection_Homo sapiens_hsa053300.64014705
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63452428
100Autoimmune thyroid disease_Homo sapiens_hsa053200.62061909
101Calcium signaling pathway_Homo sapiens_hsa040200.61302346
102Sulfur relay system_Homo sapiens_hsa041220.60738513
103ABC transporters_Homo sapiens_hsa020100.60489778
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57843323
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57684322
106AMPK signaling pathway_Homo sapiens_hsa041520.57572818
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56044636
108Endocytosis_Homo sapiens_hsa041440.55303739
109Synaptic vesicle cycle_Homo sapiens_hsa047210.54669489
110Systemic lupus erythematosus_Homo sapiens_hsa053220.53538256
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53291789
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.53241467
113Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53003633
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52275446
115Arginine and proline metabolism_Homo sapiens_hsa003300.52074768
116* Salivary secretion_Homo sapiens_hsa049700.51689382
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51674762
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51250288
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50736021
120Inositol phosphate metabolism_Homo sapiens_hsa005620.49936741
121* Cardiac muscle contraction_Homo sapiens_hsa042600.49777500
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47766513
123Tyrosine metabolism_Homo sapiens_hsa003500.46012253
124Vitamin digestion and absorption_Homo sapiens_hsa049770.45844864
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43970852
126Metabolic pathways_Homo sapiens_hsa011000.43501162
127Taste transduction_Homo sapiens_hsa047420.43430157
128VEGF signaling pathway_Homo sapiens_hsa043700.41966083
129Sulfur metabolism_Homo sapiens_hsa009200.40846499
130Circadian rhythm_Homo sapiens_hsa047100.38487901
131* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37150786
132Circadian entrainment_Homo sapiens_hsa047130.36544097
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35955580
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32530112
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32124630
136Pyrimidine metabolism_Homo sapiens_hsa002400.28725218
137Alcoholism_Homo sapiens_hsa050340.27821768
138Cocaine addiction_Homo sapiens_hsa050300.26049808
139HIF-1 signaling pathway_Homo sapiens_hsa040660.20893180
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20070311
141Basal cell carcinoma_Homo sapiens_hsa052170.19415477
142* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.15703406
143Wnt signaling pathway_Homo sapiens_hsa043100.15555034
144Type II diabetes mellitus_Homo sapiens_hsa049300.15319098
145Insulin resistance_Homo sapiens_hsa049310.13988559
146B cell receptor signaling pathway_Homo sapiens_hsa046620.13620823
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.13172738
148* Insulin secretion_Homo sapiens_hsa049110.12743512
149Salmonella infection_Homo sapiens_hsa051320.11808731
150N-Glycan biosynthesis_Homo sapiens_hsa005100.11349224
151Glutamatergic synapse_Homo sapiens_hsa047240.09034410
152* cAMP signaling pathway_Homo sapiens_hsa040240.06123750
153Toxoplasmosis_Homo sapiens_hsa051450.05686690
154Aldosterone synthesis and secretion_Homo sapiens_hsa049250.05092160
155Longevity regulating pathway - mammal_Homo sapiens_hsa042110.04411126
156Viral carcinogenesis_Homo sapiens_hsa052030.04275959
157Retinol metabolism_Homo sapiens_hsa008300.03789227
158Dopaminergic synapse_Homo sapiens_hsa047280.01702907
159Peroxisome_Homo sapiens_hsa041460.01227830
160Oxytocin signaling pathway_Homo sapiens_hsa049210.00626651

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