ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	iron coordination entity transport (GO:1901678)	5.71111457
2	C4-dicarboxylate transport (GO:0015740)	5.65103557
3	platelet dense granule organization (GO:0060155)	5.53899659
4	cellular response to exogenous dsRNA (GO:0071360)	5.40388873
5	magnesium ion transport (GO:0015693)	5.14466798
6	neural tube formation (GO:0001841)	5.02299044
7	positive regulation of mitochondrial fission (GO:0090141)	4.91470491
8	mitochondrial calcium ion transport (GO:0006851)	4.56806991
9	chondrocyte proliferation (GO:0035988)	4.30465615
10	regulation of mitochondrial fission (GO:0090140)	4.18022833
11	protein-cofactor linkage (GO:0018065)	4.14644215
12	organelle disassembly (GO:1903008)	4.13609239
13	arginine catabolic process (GO:0006527)	4.10269589
14	ovulation from ovarian follicle (GO:0001542)	4.07674628
15	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.99813087
16	seminiferous tubule development (GO:0072520)	3.89418058
17	regulation of cardiac muscle cell contraction (GO:0086004)	3.84344565
18	cytokine production involved in immune response (GO:0002367)	3.75523008
19	anterograde synaptic vesicle transport (GO:0048490)	3.71699268
20	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.68372535
21	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.68372535
22	protein prenylation (GO:0018342)	3.64363067
23	prenylation (GO:0097354)	3.64363067
24	nuclear pore complex assembly (GO:0051292)	3.59156888
25	positive regulation of developmental pigmentation (GO:0048087)	3.48116691
26	male meiosis I (GO:0007141)	3.47664116
27	dicarboxylic acid catabolic process (GO:0043649)	3.47253030
28	myeloid leukocyte mediated immunity (GO:0002444)	3.46103333
29	mitochondrial calcium ion homeostasis (GO:0051560)	3.42768967
30	neutrophil mediated immunity (GO:0002446)	3.38586729
31	endoderm formation (GO:0001706)	3.35584605
32	negative regulation of chemokine production (GO:0032682)	3.27460893
33	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.23294171
34	regulation of translation, ncRNA-mediated (GO:0045974)	3.23294171
35	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.23294171
36	positive regulation of sodium ion transmembrane transport (GO:1902307)	3.22168861
37	positive regulation of gastrulation (GO:2000543)	3.18486849
38	intraciliary transport (GO:0042073)	3.17412709
39	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	3.14225036
40	positive regulation of calcium ion import (GO:0090280)	3.11051598
41	microglial cell activation (GO:0001774)	3.09540940
42	mannosylation (GO:0097502)	3.07806729
43	regulation of gastrulation (GO:0010470)	3.07777305
44	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	3.06017598
45	photoreceptor cell maintenance (GO:0045494)	3.03632794
46	negative regulation of protein tyrosine kinase activity (GO:0061099)	3.03442906
47	pore complex assembly (GO:0046931)	3.03283518
48	regulation of regulatory T cell differentiation (GO:0045589)	3.01828749
49	histone H3-K4 trimethylation (GO:0080182)	3.00656197
50	folic acid metabolic process (GO:0046655)	2.99542499
51	synaptic vesicle endocytosis (GO:0048488)	2.96591265
52	retina layer formation (GO:0010842)	2.95035181
53	transepithelial transport (GO:0070633)	2.94694969
54	production of molecular mediator of immune response (GO:0002440)	2.94355226
55	telomere maintenance via telomerase (GO:0007004)	2.93739235
56	DNA replication-dependent nucleosome organization (GO:0034723)	2.93374216
57	DNA replication-dependent nucleosome assembly (GO:0006335)	2.93374216
58	behavioral response to ethanol (GO:0048149)	2.93186288
59	ncRNA catabolic process (GO:0034661)	2.92890561
60	regulation of pigment cell differentiation (GO:0050932)	2.92185896
61	regulation of actin filament-based movement (GO:1903115)	2.91251109
62	cellular response to interferon-beta (GO:0035458)	2.90912339
63	positive regulation of vesicle fusion (GO:0031340)	2.86368636
64	arginine metabolic process (GO:0006525)	2.84472359
65	killing of cells of other organism (GO:0031640)	2.80326899
66	disruption of cells of other organism (GO:0044364)	2.80326899
67	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.80107114
68	translesion synthesis (GO:0019985)	2.79754108
69	regulation of interleukin-8 biosynthetic process (GO:0045414)	2.78370311
70	membrane raft organization (GO:0031579)	2.77463134
71	L-glutamate transport (GO:0015813)	2.77221546
72	epithelial cell differentiation involved in kidney development (GO:0035850)	2.76971252
73	pyrimidine dimer repair (GO:0006290)	2.75222402
74	organ formation (GO:0048645)	2.74923390
75	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.74803271
76	nitric oxide mediated signal transduction (GO:0007263)	2.73963753
77	heparin biosynthetic process (GO:0030210)	2.73665839
78	heparin metabolic process (GO:0030202)	2.73665839
79	acidic amino acid transport (GO:0015800)	2.73081000
80	endothelial cell morphogenesis (GO:0001886)	2.72558605
81	tyrosine phosphorylation of STAT protein (GO:0007260)	2.72136482
82	embryonic epithelial tube formation (GO:0001838)	2.69393576
83	peptidyl-cysteine modification (GO:0018198)	2.68877189
84	endosome to melanosome transport (GO:0035646)	2.68429164
85	endosome to pigment granule transport (GO:0043485)	2.68429164
86	secretory granule organization (GO:0033363)	2.67947526
87	protein K11-linked deubiquitination (GO:0035871)	2.67116805
88	positive regulation of receptor recycling (GO:0001921)	2.64618218
89	nuclear pore organization (GO:0006999)	2.63460843
90	negative regulation of interleukin-8 production (GO:0032717)	2.62798764
91	rhodopsin mediated signaling pathway (GO:0016056)	2.58303262
92	fatty acid elongation (GO:0030497)	2.57081009
93	negative regulation of endothelial cell migration (GO:0010596)	2.56502959
94	N-acetylneuraminate metabolic process (GO:0006054)	2.54188109
95	regulation of heterotypic cell-cell adhesion (GO:0034114)	2.54097908
96	negative regulation of osteoclast differentiation (GO:0045671)	2.53954107
97	alanine transport (GO:0032328)	2.53142055
98	positive regulation of B cell differentiation (GO:0045579)	2.52304683
99	microtubule depolymerization (GO:0007019)	2.51196129
100	centriole replication (GO:0007099)	2.49254975

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.80061898
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.70983128
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.66292984
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.47936033
5	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.82346808
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.79041867
7	VDR_22108803_ChIP-Seq_LS180_Human	2.77992283
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.76676345
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.71030026
10	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.62523372
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.32980010
12	E2F7_22180533_ChIP-Seq_HELA_Human	2.27944018
13	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.27298692
14	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.23890829
15	ER_23166858_ChIP-Seq_MCF-7_Human	2.13184040
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.09068687
17	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.04096821
18	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.02901224
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.02709898
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.01860161
21	EWS_26573619_Chip-Seq_HEK293_Human	2.01759658
22	TP53_16413492_ChIP-PET_HCT116_Human	2.01406869
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.98988022
24	P300_19829295_ChIP-Seq_ESCs_Human	1.98755055
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.96553332
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.89509052
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.86808597
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.78612293
29	STAT3_23295773_ChIP-Seq_U87_Human	1.77834864
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.75422794
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.74430868
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.74430868
33	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.71870634
34	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.70724329
35	TCF4_23295773_ChIP-Seq_U87_Human	1.67351196
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.64147802
37	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.61442598
38	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.61384528
39	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.59422017
40	GBX2_23144817_ChIP-Seq_PC3_Human	1.59416328
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53085950
42	TAF15_26573619_Chip-Seq_HEK293_Human	1.52870452
43	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.52290819
44	FUS_26573619_Chip-Seq_HEK293_Human	1.51544410
45	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.50318864
46	SMAD4_21799915_ChIP-Seq_A2780_Human	1.48519823
47	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.47141819
48	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.46903239
49	ELK1_19687146_ChIP-ChIP_HELA_Human	1.45227276
50	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.41285227
51	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32952672
52	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.31256192
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.31143414
54	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.30960285
55	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.28371802
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24802003
57	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24088344
58	AR_25329375_ChIP-Seq_VCAP_Human	1.23449027
59	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.23271968
60	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.15202228
61	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.14743405
62	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13977940
63	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.13500737
64	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13400565
65	SCL_19346495_ChIP-Seq_HPC-7_Human	1.12492307
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11283997
67	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.10185130
68	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09829414
69	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.09300197
70	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.08917095
71	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.06733843
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.06389627
73	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.06377634
74	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05727605
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03836199
76	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02606889
77	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.01530154
78	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.01204840
79	CJUN_26792858_Chip-Seq_BT549_Human	1.00892203
80	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.00873283
81	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.99647417
82	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98919565
83	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.98081380
84	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.96601293
85	KDM2B_26808549_Chip-Seq_REH_Human	0.94987378
86	TP53_22573176_ChIP-Seq_HFKS_Human	0.94922927
87	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94841870
88	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.94841870
89	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.93940889
90	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93631308
91	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.91441800
92	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.90931690
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.90621821
94	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.90172803
95	VDR_24787735_ChIP-Seq_THP-1_Human	0.89310589
96	GATA3_26560356_Chip-Seq_TH2_Human	0.88661639
97	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.88499258
98	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.88229910
99	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.87791096
100	VDR_23849224_ChIP-Seq_CD4+_Human	0.86652625

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.48491785
2	MP0005645_abnormal_hypothalamus_physiol	3.59212546
3	MP0003646_muscle_fatigue	3.07528049
4	MP0003183_abnormal_peptide_metabolism	2.71651536
5	MP0008058_abnormal_DNA_repair	2.49564776
6	MP0008057_abnormal_DNA_replication	2.41921063
7	MP0006054_spinal_hemorrhage	2.38990983
8	MP0001501_abnormal_sleep_pattern	2.36934849
9	MP0003656_abnormal_erythrocyte_physiolo	2.27022719
10	MP0009046_muscle_twitch	2.26431873
11	MP0003880_abnormal_central_pattern	2.26305733
12	MP0008260_abnormal_autophagy	2.19445502
13	MP0000013_abnormal_adipose_tissue	2.19059141
14	MP0005646_abnormal_pituitary_gland	2.15788640
15	MP0002877_abnormal_melanocyte_morpholog	1.98889506
16	MP0004484_altered_response_of	1.88267770
17	MP0005551_abnormal_eye_electrophysiolog	1.85556918
18	MP0000427_abnormal_hair_cycle	1.83663737
19	MP0004147_increased_porphyrin_level	1.77281708
20	MP0005083_abnormal_biliary_tract	1.74940836
21	MP0000371_diluted_coat_color	1.63551824
22	MP0004233_abnormal_muscle_weight	1.59640559
23	MP0002102_abnormal_ear_morphology	1.52703850
24	MP0004043_abnormal_pH_regulation	1.52320905
25	MP0006035_abnormal_mitochondrial_morpho	1.51978180
26	MP0000015_abnormal_ear_pigmentation	1.50608814
27	MP0002234_abnormal_pharynx_morphology	1.46123466
28	MP0002909_abnormal_adrenal_gland	1.43666122
29	MP0003567_abnormal_fetal_cardiomyocyte	1.43133355
30	MP0010094_abnormal_chromosome_stability	1.40266637
31	MP0005174_abnormal_tail_pigmentation	1.36019406
32	MP0002127_abnormal_cardiovascular_syste	1.34564728
33	MP0006276_abnormal_autonomic_nervous	1.31713662
34	MP0005167_abnormal_blood-brain_barrier	1.31218248
35	MP0003828_pulmonary_edema	1.30288632
36	MP0004185_abnormal_adipocyte_glucose	1.28998032
37	MP0006072_abnormal_retinal_apoptosis	1.28350703
38	MP0002160_abnormal_reproductive_system	1.27343149
39	MP0004142_abnormal_muscle_tone	1.21470168
40	MP0000383_abnormal_hair_follicle	1.21214242
41	MP0002177_abnormal_outer_ear	1.19666996
42	MP0001324_abnormal_eye_pigmentation	1.19094503
43	MP0002751_abnormal_autonomic_nervous	1.18135847
44	MP0002638_abnormal_pupillary_reflex	1.17301334
45	MP0004133_heterotaxia	1.17018440
46	MP0004742_abnormal_vestibular_system	1.16790873
47	MP0005253_abnormal_eye_physiology	1.16531417
48	MP0003221_abnormal_cardiomyocyte_apopto	1.11585220
49	MP0000358_abnormal_cell_content/	1.11228105
50	MP0002095_abnormal_skin_pigmentation	1.08666957
51	MP0003045_fibrosis	1.08057337
52	MP0004145_abnormal_muscle_electrophysio	1.05275542
53	MP0001661_extended_life_span	1.03105040
54	MP0003950_abnormal_plasma_membrane	1.02672936
55	MP0001919_abnormal_reproductive_system	1.01298239
56	MP0004883_abnormal_blood_vessel	1.01274455
57	MP0009785_altered_susceptibility_to	0.97613161
58	MP0003806_abnormal_nucleotide_metabolis	0.95338643
59	MP0002396_abnormal_hematopoietic_system	0.94768876
60	MP0005389_reproductive_system_phenotype	0.93233365
61	MP0002067_abnormal_sensory_capabilities	0.91277478
62	MP0003890_abnormal_embryonic-extraembry	0.90497382
63	MP0004036_abnormal_muscle_relaxation	0.90453017
64	MP0004084_abnormal_cardiac_muscle	0.89618125
65	MP0005084_abnormal_gallbladder_morpholo	0.88611634
66	MP0002184_abnormal_innervation	0.87284962
67	MP0002272_abnormal_nervous_system	0.86812290
68	MP0002229_neurodegeneration	0.85878311
69	MP0001486_abnormal_startle_reflex	0.84523764
70	MP0008877_abnormal_DNA_methylation	0.83539542
71	MP0004134_abnormal_chest_morphology	0.81874234
72	MP0004019_abnormal_vitamin_homeostasis	0.81811119
73	MP0005464_abnormal_platelet_physiology	0.81450223
74	MP0008775_abnormal_heart_ventricle	0.80803458
75	MP0001764_abnormal_homeostasis	0.79478973
76	MP0001299_abnormal_eye_distance/	0.79406110
77	MP0005397_hematopoietic_system_phenotyp	0.78405872
78	MP0001545_abnormal_hematopoietic_system	0.78405872
79	MP0003693_abnormal_embryo_hatching	0.78212819
80	MP0003868_abnormal_feces_composition	0.78098863
81	MP0005266_abnormal_metabolism	0.76710426
82	MP0002928_abnormal_bile_duct	0.76099593
83	MP0004808_abnormal_hematopoietic_stem	0.75783870
84	MP0001756_abnormal_urination	0.74804886
85	MP0000049_abnormal_middle_ear	0.74484821
86	MP0003943_abnormal_hepatobiliary_system	0.74174392
87	MP0000685_abnormal_immune_system	0.73404282
88	MP0005195_abnormal_posterior_eye	0.72484111
89	MP0000749_muscle_degeneration	0.71234438
90	MP0002168_other_aberrant_phenotype	0.70326974
91	MP0003121_genomic_imprinting	0.70013124
92	MP0002557_abnormal_social/conspecific_i	0.69537138
93	MP0001879_abnormal_lymphatic_vessel	0.68370415
94	MP0000372_irregular_coat_pigmentation	0.66997420
95	MP0003786_premature_aging	0.65817487
96	MP0002108_abnormal_muscle_morphology	0.64757564
97	MP0010386_abnormal_urinary_bladder	0.64666959
98	MP0002009_preneoplasia	0.64172724
99	MP0003718_maternal_effect	0.62143596
100	MP0002075_abnormal_coat/hair_pigmentati	0.62128411

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	6.63486232
2	Tetany (HP:0001281)	6.00841031
3	Hypomagnesemia (HP:0002917)	5.54790799
4	Abnormal drinking behavior (HP:0030082)	4.71491359
5	Polydipsia (HP:0001959)	4.71491359
6	Fibular aplasia (HP:0002990)	4.53467685
7	Abnormality of magnesium homeostasis (HP:0004921)	4.37017755
8	Hypothermia (HP:0002045)	3.82914652
9	Dyschromatopsia (HP:0007641)	3.74151494
10	Volvulus (HP:0002580)	3.71447786
11	Renal cortical cysts (HP:0000803)	3.38485029
12	Chronic hepatic failure (HP:0100626)	3.02355839
13	Polyuria (HP:0000103)	2.97038879
14	Increased purine levels (HP:0004368)	2.91543814
15	Hyperuricemia (HP:0002149)	2.91543814
16	Oral leukoplakia (HP:0002745)	2.90587549
17	Renal Fanconi syndrome (HP:0001994)	2.79017251
18	Recurrent bacterial skin infections (HP:0005406)	2.78302359
19	Exertional dyspnea (HP:0002875)	2.75172285
20	Tubulointerstitial abnormality (HP:0001969)	2.66780082
21	Increased hepatocellular lipid droplets (HP:0006565)	2.66574960
22	Thyroid-stimulating hormone excess (HP:0002925)	2.65620628
23	Abnormality of the anterior horn cell (HP:0006802)	2.63229865
24	Degeneration of anterior horn cells (HP:0002398)	2.63229865
25	Cone-rod dystrophy (HP:0000548)	2.61852961
26	Abnormality of the renal medulla (HP:0100957)	2.57950597
27	Gaze-evoked nystagmus (HP:0000640)	2.54982270
28	Decreased central vision (HP:0007663)	2.52121114
29	Nephronophthisis (HP:0000090)	2.50325215
30	Lipid accumulation in hepatocytes (HP:0006561)	2.49072813
31	Central scotoma (HP:0000603)	2.45958115
32	Pancreatic cysts (HP:0001737)	2.40761723
33	Progressive inability to walk (HP:0002505)	2.40476672
34	Dry hair (HP:0011359)	2.37102817
35	Abnormality of the renal cortex (HP:0011035)	2.36088331
36	Spinal muscular atrophy (HP:0007269)	2.34428445
37	Dialeptic seizures (HP:0011146)	2.33621316
38	Congenital hepatic fibrosis (HP:0002612)	2.32931054
39	Atonic seizures (HP:0010819)	2.32042769
40	Abnormal urine output (HP:0012590)	2.29438334
41	Pancreatic fibrosis (HP:0100732)	2.27190925
42	Dyskinesia (HP:0100660)	2.23308901
43	Albinism (HP:0001022)	2.22144302
44	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.21725455
45	True hermaphroditism (HP:0010459)	2.19575410
46	Intrahepatic cholestasis (HP:0001406)	2.18804917
47	Astrocytoma (HP:0009592)	2.17987612
48	Abnormality of the astrocytes (HP:0100707)	2.17987612
49	Hyperventilation (HP:0002883)	2.15511942
50	Abnormality of macular pigmentation (HP:0008002)	2.13862607
51	Abnormality of the preputium (HP:0100587)	2.11897757
52	Opisthotonus (HP:0002179)	2.10923514
53	Small hand (HP:0200055)	2.10393006
54	Astigmatism (HP:0000483)	2.09813621
55	Absence seizures (HP:0002121)	2.06802846
56	Hydroureter (HP:0000072)	2.05513068
57	Febrile seizures (HP:0002373)	2.04958494
58	Renal tubular acidosis (HP:0001947)	2.03995749
59	Abolished electroretinogram (ERG) (HP:0000550)	2.03577614
60	Eosinophilia (HP:0001880)	2.03164294
61	Medial flaring of the eyebrow (HP:0010747)	2.01733112
62	Type I transferrin isoform profile (HP:0003642)	2.01623247
63	Hypoplastic iliac wings (HP:0002866)	2.00799917
64	Mitochondrial inheritance (HP:0001427)	1.97608062
65	Broad ribs (HP:0000885)	1.95896740
66	Enlarged epiphyses (HP:0010580)	1.93784846
67	Enlarged kidneys (HP:0000105)	1.92898679
68	Abnormal biliary tract physiology (HP:0012439)	1.91843382
69	Bile duct proliferation (HP:0001408)	1.91843382
70	Renal tubular dysfunction (HP:0000124)	1.90293893
71	Aplastic anemia (HP:0001915)	1.88625427
72	Stage 5 chronic kidney disease (HP:0003774)	1.83320242
73	Hypoalphalipoproteinemia (HP:0003233)	1.82567785
74	Widely spaced teeth (HP:0000687)	1.82555886
75	Meckel diverticulum (HP:0002245)	1.78338822
76	Thrombocytosis (HP:0001894)	1.78298887
77	Abnormality of chromosome stability (HP:0003220)	1.77178502
78	Recurrent abscess formation (HP:0002722)	1.76985421
79	Toxemia of pregnancy (HP:0100603)	1.76145101
80	Bulbous nose (HP:0000414)	1.75286320
81	Abnormality of the ileum (HP:0001549)	1.75146634
82	Abnormality of the prostate (HP:0008775)	1.74702592
83	Ependymoma (HP:0002888)	1.72248588
84	Abnormality of purine metabolism (HP:0004352)	1.72038219
85	Horizontal nystagmus (HP:0000666)	1.70771402
86	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.69528233
87	Thyroiditis (HP:0100646)	1.69461570
88	Methylmalonic aciduria (HP:0012120)	1.67938669
89	Hemiparesis (HP:0001269)	1.67217209
90	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.67044680
91	Congenital primary aphakia (HP:0007707)	1.66188607
92	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.65838604
93	Abnormality of the vertebral endplates (HP:0005106)	1.64922211
94	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.64397927
95	Abnormality of renal excretion (HP:0011036)	1.63923251
96	Clubbing of toes (HP:0100760)	1.63125081
97	Cerebral edema (HP:0002181)	1.63121053
98	Abnormal protein N-linked glycosylation (HP:0012347)	1.62222077
99	Abnormal protein glycosylation (HP:0012346)	1.62222077
100	Abnormal glycosylation (HP:0012345)	1.62222077

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.51735205
2	TAOK3	3.38671185
3	WNK3	2.93914628
4	BCKDK	2.59551505
5	NUAK1	2.58955683
6	TEC	2.57834863
7	CAMKK2	2.42825763
8	BCR	2.29752435
9	BMPR1B	2.01432749
10	MKNK2	1.95431561
11	MAP3K12	1.85220348
12	MAPK13	1.84225279
13	ITK	1.83406285
14	MARK1	1.74864178
15	TIE1	1.57288532
16	MKNK1	1.56863874
17	CAMK4	1.56486563
18	PLK2	1.50639362
19	MARK3	1.49053001
20	PIK3CG	1.45691635
21	PLK4	1.45482991
22	MAPK15	1.43977238
23	BTK	1.42836743
24	TNIK	1.42771998
25	MAP3K4	1.40553912
26	PAK3	1.37729212
27	KSR1	1.30763471
28	SRPK1	1.25285735
29	CAMK1G	1.14824829
30	TLK1	1.12011868
31	VRK1	1.08781760
32	ACVR1B	1.08324147
33	CDK8	1.07479091
34	AKT3	1.04261961
35	STK39	1.03298204
36	INSRR	1.02289371
37	PRKCE	0.99515715
38	IRAK4	0.99441543
39	CAMK1	0.98882414
40	MAPKAPK3	0.95697176
41	DYRK3	0.95117447
42	SYK	0.94238839
43	CLK1	0.93688784
44	OXSR1	0.89690693
45	LATS1	0.89659880
46	TRIB3	0.89429058
47	MINK1	0.88444824
48	EGFR	0.85128943
49	CDK3	0.85077868
50	TGFBR2	0.83880947
51	DYRK1A	0.83769878
52	CSNK1G2	0.82842881
53	ERBB3	0.80190288
54	CSNK1G1	0.78870649
55	ATR	0.78759929
56	CAMK1D	0.78174887
57	KDR	0.77600695
58	IKBKE	0.77329991
59	BRSK2	0.77143659
60	CSNK1G3	0.76827112
61	TGFBR1	0.76475396
62	CSNK1A1L	0.75049213
63	STK4	0.74653455
64	SGK2	0.73561327
65	FER	0.71025542
66	ERBB2	0.69781867
67	ADRBK2	0.69048042
68	PRKCQ	0.68482929
69	KIT	0.68113760
70	TBK1	0.67358561
71	FES	0.65987287
72	PKN1	0.65796687
73	PIM1	0.63151634
74	ATM	0.60359786
75	LYN	0.57030303
76	IGF1R	0.56968064
77	PRKD2	0.55571621
78	BLK	0.55507145
79	CDK7	0.55496027
80	MAP4K2	0.54870751
81	CAMK2A	0.54129971
82	LCK	0.53742520
83	RPS6KA5	0.49487585
84	EIF2AK2	0.48472748
85	MAP2K7	0.47970483
86	DMPK	0.47414088
87	CDC7	0.47022515
88	PTK6	0.46132514
89	FGFR2	0.46127328
90	LIMK1	0.45968287
91	CSNK1A1	0.45853586
92	OBSCN	0.45668690
93	CHUK	0.45103626
94	BRD4	0.44751406
95	MAPK9	0.44601585
96	RPS6KA4	0.44188174
97	PLK3	0.44153782
98	MAPK10	0.43988569
99	GRK5	0.41547477
100	ILK	0.41224497

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	4.07505005
2	Phototransduction_Homo sapiens_hsa04744	3.64509285
3	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.94982254
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.72116850
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.66707283
6	Fatty acid elongation_Homo sapiens_hsa00062	2.58052265
7	Salivary secretion_Homo sapiens_hsa04970	2.54180787
8	One carbon pool by folate_Homo sapiens_hsa00670	2.12266547
9	Asthma_Homo sapiens_hsa05310	2.02239594
10	Protein export_Homo sapiens_hsa03060	1.95785864
11	Basal transcription factors_Homo sapiens_hsa03022	1.95290729
12	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.90978079
13	African trypanosomiasis_Homo sapiens_hsa05143	1.79797464
14	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.67637451
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.64921399
16	RNA polymerase_Homo sapiens_hsa03020	1.62850419
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.57882226
18	Circadian rhythm_Homo sapiens_hsa04710	1.55059951
19	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.44942098
20	Homologous recombination_Homo sapiens_hsa03440	1.41546830
21	Propanoate metabolism_Homo sapiens_hsa00640	1.38086639
22	Circadian entrainment_Homo sapiens_hsa04713	1.35744349
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.34736427
24	Morphine addiction_Homo sapiens_hsa05032	1.33772413
25	Taste transduction_Homo sapiens_hsa04742	1.33314893
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.26082593
27	Allograft rejection_Homo sapiens_hsa05330	1.25793166
28	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.23616173
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.21752289
30	Graft-versus-host disease_Homo sapiens_hsa05332	1.20523435
31	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.20173385
32	Fatty acid metabolism_Homo sapiens_hsa01212	1.13169070
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.13037700
34	Type I diabetes mellitus_Homo sapiens_hsa04940	1.09306976
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08423362
36	Nicotine addiction_Homo sapiens_hsa05033	1.07342315
37	Leishmaniasis_Homo sapiens_hsa05140	1.06321357
38	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.02385560
39	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.02335361
40	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.00006226
41	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.99162787
42	Linoleic acid metabolism_Homo sapiens_hsa00591	0.96394130
43	Rheumatoid arthritis_Homo sapiens_hsa05323	0.92670912
44	Glutamatergic synapse_Homo sapiens_hsa04724	0.90614281
45	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.90471451
46	Viral myocarditis_Homo sapiens_hsa05416	0.89671373
47	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.89385793
48	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.88341960
49	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.87912019
50	GABAergic synapse_Homo sapiens_hsa04727	0.87305083
51	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.87233385
52	RNA degradation_Homo sapiens_hsa03018	0.87030391
53	Malaria_Homo sapiens_hsa05144	0.85896360
54	Alcoholism_Homo sapiens_hsa05034	0.84572859
55	Butanoate metabolism_Homo sapiens_hsa00650	0.84064666
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83236596
57	Caffeine metabolism_Homo sapiens_hsa00232	0.82275191
58	Tight junction_Homo sapiens_hsa04530	0.80975798
59	Purine metabolism_Homo sapiens_hsa00230	0.79266505
60	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.78523911
61	Phagosome_Homo sapiens_hsa04145	0.75626642
62	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.75292122
63	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.73318899
64	Herpes simplex infection_Homo sapiens_hsa05168	0.72608777
65	Tuberculosis_Homo sapiens_hsa05152	0.69217185
66	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.68434611
67	Nitrogen metabolism_Homo sapiens_hsa00910	0.67243838
68	Olfactory transduction_Homo sapiens_hsa04740	0.66576255
69	Serotonergic synapse_Homo sapiens_hsa04726	0.65088367
70	Amphetamine addiction_Homo sapiens_hsa05031	0.64046232
71	Hepatitis B_Homo sapiens_hsa05161	0.63497007
72	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.61637773
73	Arginine biosynthesis_Homo sapiens_hsa00220	0.60904427
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.60889567
75	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.60640357
76	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.60496754
77	Hepatitis C_Homo sapiens_hsa05160	0.59342599
78	Long-term depression_Homo sapiens_hsa04730	0.57564843
79	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.57470072
80	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.53151820
81	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47082588
82	Base excision repair_Homo sapiens_hsa03410	0.46943445
83	Legionellosis_Homo sapiens_hsa05134	0.46802485
84	Influenza A_Homo sapiens_hsa05164	0.46227961
85	Small cell lung cancer_Homo sapiens_hsa05222	0.44184753
86	Peroxisome_Homo sapiens_hsa04146	0.43747656
87	Dopaminergic synapse_Homo sapiens_hsa04728	0.43149236
88	Nucleotide excision repair_Homo sapiens_hsa03420	0.41875759
89	Ras signaling pathway_Homo sapiens_hsa04014	0.39339131
90	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38633690
91	Cocaine addiction_Homo sapiens_hsa05030	0.37898219
92	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.37840964
93	Cholinergic synapse_Homo sapiens_hsa04725	0.37009511
94	Renin-angiotensin system_Homo sapiens_hsa04614	0.36259741
95	Pancreatic secretion_Homo sapiens_hsa04972	0.34915821
96	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.34584277
97	Mismatch repair_Homo sapiens_hsa03430	0.34200284
98	Viral carcinogenesis_Homo sapiens_hsa05203	0.33753164
99	Pyrimidine metabolism_Homo sapiens_hsa00240	0.30835073
100	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.29974349

ATP1B1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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