ATP1B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.67135863
2synaptic vesicle maturation (GO:0016188)5.64603966
3locomotory exploration behavior (GO:0035641)5.61459578
4central nervous system myelination (GO:0022010)5.53527041
5axon ensheathment in central nervous system (GO:0032291)5.53527041
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.35584137
7presynaptic membrane assembly (GO:0097105)5.14781521
8response to pheromone (GO:0019236)4.98857153
9synaptic vesicle exocytosis (GO:0016079)4.97934536
10presynaptic membrane organization (GO:0097090)4.89206874
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.87890529
12G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.82689318
13gamma-aminobutyric acid transport (GO:0015812)4.80775490
14L-amino acid import (GO:0043092)4.76966582
15* cellular potassium ion homeostasis (GO:0030007)4.74266624
16* sodium ion export (GO:0071436)4.59378364
17glutamate secretion (GO:0014047)4.55191668
18regulation of synaptic vesicle exocytosis (GO:2000300)4.54549633
19neurotransmitter-gated ion channel clustering (GO:0072578)4.48894274
20vocalization behavior (GO:0071625)4.43134914
21neurotransmitter secretion (GO:0007269)4.35049092
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.32466055
23cerebellar granule cell differentiation (GO:0021707)4.30856967
24retinal rod cell development (GO:0046548)4.29968244
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.24717814
26glutamate receptor signaling pathway (GO:0007215)4.19846491
27amino acid import (GO:0043090)4.19648097
28protein localization to synapse (GO:0035418)4.16666563
29layer formation in cerebral cortex (GO:0021819)4.10238670
30ionotropic glutamate receptor signaling pathway (GO:0035235)4.05881003
31C4-dicarboxylate transport (GO:0015740)4.00835224
32regulation of synaptic vesicle transport (GO:1902803)4.00049237
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.96256274
34neuronal ion channel clustering (GO:0045161)3.96079797
35cerebellar Purkinje cell differentiation (GO:0021702)3.93279536
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.92251530
37synaptic transmission, glutamatergic (GO:0035249)3.89789990
38neuronal action potential propagation (GO:0019227)3.88236589
39dendritic spine morphogenesis (GO:0060997)3.86624616
40* cell communication by electrical coupling (GO:0010644)3.81268631
41regulation of glutamate receptor signaling pathway (GO:1900449)3.80893266
42positive regulation of synapse maturation (GO:0090129)3.79381096
43response to auditory stimulus (GO:0010996)3.78633030
44* potassium ion homeostasis (GO:0055075)3.78519086
45exploration behavior (GO:0035640)3.77567528
46long-term memory (GO:0007616)3.76139219
47alanine transport (GO:0032328)3.75422393
48neurotransmitter transport (GO:0006836)3.74270464
49mechanosensory behavior (GO:0007638)3.73110377
50synaptic vesicle endocytosis (GO:0048488)3.66611598
51negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.63636874
52glycine transport (GO:0015816)3.61239281
53positive regulation of dendritic spine development (GO:0060999)3.60013124
54positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.58367224
55regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.57724985
56neuron-neuron synaptic transmission (GO:0007270)3.55889902
57regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.55139437
58* cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.52331705
59negative regulation of cytosolic calcium ion concentration (GO:0051481)3.51718763
60regulation of neuronal synaptic plasticity (GO:0048168)3.44959098
61neuron cell-cell adhesion (GO:0007158)3.43270283
62gamma-aminobutyric acid signaling pathway (GO:0007214)3.42327221
63* potassium ion import (GO:0010107)3.42044278
64retinal cone cell development (GO:0046549)3.41628463
65neuromuscular process controlling posture (GO:0050884)3.40808626
66membrane hyperpolarization (GO:0060081)3.36236642
67regulation of synapse structural plasticity (GO:0051823)3.35663828
68cerebellar Purkinje cell layer development (GO:0021680)3.35057669
69regulation of neurotransmitter levels (GO:0001505)3.34603941
70detection of light stimulus involved in visual perception (GO:0050908)3.33713333
71detection of light stimulus involved in sensory perception (GO:0050962)3.33713333
72innervation (GO:0060384)3.33404977
73regulation of long-term neuronal synaptic plasticity (GO:0048169)3.32792641
74acidic amino acid transport (GO:0015800)3.32257898
75regulation of neurotransmitter secretion (GO:0046928)3.30414868
76regulation of synaptic transmission, glutamatergic (GO:0051966)3.29884557
77negative regulation of synaptic transmission, GABAergic (GO:0032229)3.27821852
78regulation of synaptic plasticity (GO:0048167)3.26712224
79cell differentiation in hindbrain (GO:0021533)3.26445509
80proline transport (GO:0015824)3.24866542
81dendrite morphogenesis (GO:0048813)3.22104368
82regulation of dendritic spine morphogenesis (GO:0061001)3.20727492
83long-term synaptic potentiation (GO:0060291)3.20697786
84regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.20530705
85auditory behavior (GO:0031223)3.19889446
86transmission of nerve impulse (GO:0019226)3.19736305
87membrane depolarization during action potential (GO:0086010)3.19078853
88regulation of ARF protein signal transduction (GO:0032012)3.17601016
89positive regulation of membrane potential (GO:0045838)3.17461491
90neuron recognition (GO:0008038)3.17290011
91regulation of dendritic spine development (GO:0060998)3.15427630
92axonal fasciculation (GO:0007413)3.15375280
93regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.15282191
94regulation of neurotransmitter transport (GO:0051588)3.14271039
95* cellular sodium ion homeostasis (GO:0006883)3.14219429
96photoreceptor cell development (GO:0042461)3.12951691
97regulation of voltage-gated calcium channel activity (GO:1901385)3.12122862
98neuromuscular process controlling balance (GO:0050885)3.11277424
99membrane depolarization (GO:0051899)3.10515193
100L-glutamate transport (GO:0015813)3.07782549
101regulation of excitatory postsynaptic membrane potential (GO:0060079)3.07235300
102regulation of membrane repolarization (GO:0060306)3.07230304
103neuromuscular synaptic transmission (GO:0007274)3.06703970
104positive regulation of dendritic spine morphogenesis (GO:0061003)3.05911105
105positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.05715510
106establishment of mitochondrion localization (GO:0051654)3.05636399
107regulation of postsynaptic membrane potential (GO:0060078)3.05159065
108prepulse inhibition (GO:0060134)3.04417263
109eye photoreceptor cell development (GO:0042462)3.02875425
110regulation of respiratory system process (GO:0044065)3.01543714
111regulation of vesicle fusion (GO:0031338)2.99286856
112neurotransmitter uptake (GO:0001504)2.98724252
113postsynaptic membrane organization (GO:0001941)2.98314994
114response to histamine (GO:0034776)2.98084800
115regulation of synaptic transmission (GO:0050804)2.97824409
116astrocyte differentiation (GO:0048708)2.96845116
117positive regulation of synapse assembly (GO:0051965)2.91402173
118adult walking behavior (GO:0007628)2.90725188
119synapse assembly (GO:0007416)2.88714312
120regulation of synapse maturation (GO:0090128)2.87883537
121regulation of beta-amyloid formation (GO:1902003)2.87528820
122rhodopsin mediated signaling pathway (GO:0016056)2.86594246
123synaptic transmission (GO:0007268)2.86410516
124regulation of neurotransmitter uptake (GO:0051580)2.86278779

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.46510446
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09747727
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93657150
4DROSHA_22980978_ChIP-Seq_HELA_Human2.92093589
5GBX2_23144817_ChIP-Seq_PC3_Human2.89619553
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74528502
7REST_21632747_ChIP-Seq_MESCs_Mouse2.68553771
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67108717
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67108717
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61488325
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.58878431
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56655717
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55315962
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49578930
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.32958235
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.32829104
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31608365
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29778468
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.29204750
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.23225127
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.21714908
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.21047554
23AR_21572438_ChIP-Seq_LNCaP_Human2.19913759
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.18964099
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18696942
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12978603
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98364545
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91402471
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87207718
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.67110229
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61300778
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57359404
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44786774
34RING1B_27294783_Chip-Seq_ESCs_Mouse1.44514921
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43648979
36SMAD4_21799915_ChIP-Seq_A2780_Human1.41712504
37AR_19668381_ChIP-Seq_PC3_Human1.40565959
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34123378
39KDM2B_26808549_Chip-Seq_K562_Human1.33908156
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32190657
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32118786
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30509631
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30387344
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30312217
45RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29383237
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28309552
47RNF2_27304074_Chip-Seq_NSC_Mouse1.26992877
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.25535670
49WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25387185
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22453784
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.19890935
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19429603
53TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18607892
54AR_25329375_ChIP-Seq_VCAP_Human1.16320616
55* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15819726
56P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14736041
57STAT3_23295773_ChIP-Seq_U87_Human1.13965074
58ZNF274_21170338_ChIP-Seq_K562_Hela1.12132565
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12093428
60* RING1B_27294783_Chip-Seq_NPCs_Mouse1.10561777
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10307966
62TAF15_26573619_Chip-Seq_HEK293_Human1.09579265
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09453207
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08829078
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.08148404
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07890053
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.07804647
68YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07324849
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07225319
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07225319
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07020949
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.06603732
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06298491
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05831264
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04146606
76* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02397351
77SMAD4_21741376_ChIP-Seq_HESCs_Human1.02037532
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01943758
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01883402
80RXR_22108803_ChIP-Seq_LS180_Human1.01229763
81TP53_16413492_ChIP-PET_HCT116_Human1.00492957
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.00013750
83SMAD3_21741376_ChIP-Seq_HESCs_Human0.99636952
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99268399
85SMAD3_21741376_ChIP-Seq_ESCs_Human0.98662074
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98273429
87TCF4_23295773_ChIP-Seq_U87_Human0.97952814
88NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97897437
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96643567
90P300_19829295_ChIP-Seq_ESCs_Human0.96328269
91* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96123402
92TET1_21490601_ChIP-Seq_MESCs_Mouse0.95528530
93DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94593439
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93653284
95ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93341443
96OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93149138
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92298598
98SOX9_26525672_Chip-Seq_HEART_Mouse0.91089634
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90323780
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.89943867
101ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89828380
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89654832
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89241462
104BCAT_22108803_ChIP-Seq_LS180_Human0.88319657
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88296477
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88076200
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87686417
108TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87492871
109TP53_20018659_ChIP-ChIP_R1E_Mouse0.87106860
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87106132
111EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85030555
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85018378
113CTCF_27219007_Chip-Seq_Bcells_Human0.84406575
114KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83893234
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83777785
116TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83617184
117IGF1R_20145208_ChIP-Seq_DFB_Human0.83598704
118CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83442418
119SMC4_20622854_ChIP-Seq_HELA_Human0.82915418
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82844821
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82741747
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81557773
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80848397

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.00020128
2MP0005551_abnormal_eye_electrophysiolog3.89345397
3MP0003635_abnormal_synaptic_transmissio3.55093038
4MP0009046_muscle_twitch3.41199809
5MP0003880_abnormal_central_pattern3.21807523
6MP0005423_abnormal_somatic_nervous3.15514951
7MP0002064_seizures2.83622007
8MP0004270_analgesia2.77150077
9MP0001486_abnormal_startle_reflex2.75448482
10MP0009745_abnormal_behavioral_response2.74963936
11MP0002063_abnormal_learning/memory/cond2.62637424
12MP0004885_abnormal_endolymph2.46837363
13MP0002272_abnormal_nervous_system2.46212389
14MP0002572_abnormal_emotion/affect_behav2.30359861
15MP0001502_abnormal_circadian_rhythm2.27320157
16MP0003011_delayed_dark_adaptation2.26767491
17MP0002734_abnormal_mechanical_nocicepti2.26159132
18* MP0008569_lethality_at_weaning2.24434587
19MP0004858_abnormal_nervous_system2.22695476
20* MP0005253_abnormal_eye_physiology2.22569515
21MP0001968_abnormal_touch/_nociception2.20945124
22MP0003329_amyloid_beta_deposits2.15344320
23MP0003690_abnormal_glial_cell2.06260136
24MP0009780_abnormal_chondrocyte_physiolo2.05498270
25MP0001440_abnormal_grooming_behavior2.04660996
26MP0002090_abnormal_vision2.04143096
27MP0001984_abnormal_olfaction2.04026897
28MP0002638_abnormal_pupillary_reflex2.00846351
29* MP0006072_abnormal_retinal_apoptosis1.95971041
30* MP0002067_abnormal_sensory_capabilities1.95959675
31MP0005646_abnormal_pituitary_gland1.91510890
32MP0001501_abnormal_sleep_pattern1.81603008
33MP0002736_abnormal_nociception_after1.66375879
34MP0004145_abnormal_muscle_electrophysio1.62759703
35* MP0002229_neurodegeneration1.61126457
36MP0002909_abnormal_adrenal_gland1.61095751
37* MP0002882_abnormal_neuron_morphology1.59232974
38MP0002557_abnormal_social/conspecific_i1.58393284
39MP0003633_abnormal_nervous_system1.55948861
40MP0002184_abnormal_innervation1.55812524
41MP0002733_abnormal_thermal_nociception1.52244854
42MP0001970_abnormal_pain_threshold1.51419502
43MP0004142_abnormal_muscle_tone1.51016173
44MP0004924_abnormal_behavior1.49307461
45MP0005386_behavior/neurological_phenoty1.49307461
46MP0003136_yellow_coat_color1.48508164
47MP0004233_abnormal_muscle_weight1.47636624
48MP0003634_abnormal_glial_cell1.47150915
49MP0003122_maternal_imprinting1.44585904
50MP0000955_abnormal_spinal_cord1.44417483
51MP0000778_abnormal_nervous_system1.41818914
52MP0004215_abnormal_myocardial_fiber1.38755964
53* MP0005195_abnormal_posterior_eye1.35667034
54MP0003631_nervous_system_phenotype1.33834561
55MP0002653_abnormal_ependyma_morphology1.29690001
56MP0004811_abnormal_neuron_physiology1.29528127
57* MP0002066_abnormal_motor_capabilities/c1.26670365
58MP0003632_abnormal_nervous_system1.24760456
59MP0002735_abnormal_chemical_nociception1.23917745
60MP0003879_abnormal_hair_cell1.20448407
61MP0001529_abnormal_vocalization1.19716229
62* MP0002752_abnormal_somatic_nervous1.17912002
63MP0000566_synostosis1.17756538
64MP0000751_myopathy1.10259965
65* MP0002152_abnormal_brain_morphology1.09468447
66MP0002822_catalepsy1.07836909
67MP0005394_taste/olfaction_phenotype1.05305707
68MP0005499_abnormal_olfactory_system1.05305707
69MP0004147_increased_porphyrin_level1.04778863
70MP0002089_abnormal_postnatal_growth/wei1.04412912
71MP0003075_altered_response_to1.02916415
72MP0003137_abnormal_impulse_conducting1.02903487
73MP0005645_abnormal_hypothalamus_physiol1.02388812
74MP0004043_abnormal_pH_regulation1.00749070
75MP0004742_abnormal_vestibular_system0.97923021
76MP0000920_abnormal_myelination0.96455930
77MP0000026_abnormal_inner_ear0.94646859
78MP0000604_amyloidosis0.94514197
79MP0001986_abnormal_taste_sensitivity0.93279174
80MP0005167_abnormal_blood-brain_barrier0.93175837
81MP0001963_abnormal_hearing_physiology0.92838671
82MP0003950_abnormal_plasma_membrane0.92781560
83MP0003123_paternal_imprinting0.91522766
84MP0001324_abnormal_eye_pigmentation0.88745612
85* MP0005391_vision/eye_phenotype0.87715586
86MP0000579_abnormal_nail_morphology0.86891150
87MP0001485_abnormal_pinna_reflex0.86375023
88MP0003646_muscle_fatigue0.85911694
89MP0006292_abnormal_olfactory_placode0.83896954
90MP0000631_abnormal_neuroendocrine_gland0.82167139
91MP0003183_abnormal_peptide_metabolism0.81630647
92MP0008872_abnormal_physiological_respon0.80388166
93MP0002249_abnormal_larynx_morphology0.77686002
94MP0008877_abnormal_DNA_methylation0.77550123
95MP0005171_absent_coat_pigmentation0.77050084
96MP0001299_abnormal_eye_distance/0.76673755
97MP0003121_genomic_imprinting0.75896898
98MP0001177_atelectasis0.71858264
99MP0003861_abnormal_nervous_system0.71730788
100MP0004085_abnormal_heartbeat0.71363262
101MP0003787_abnormal_imprinting0.71143432
102* MP0002069_abnormal_eating/drinking_beha0.70740645
103MP0003938_abnormal_ear_development0.70621291
104MP0008961_abnormal_basal_metabolism0.69419692
105MP0003172_abnormal_lysosome_physiology0.68970574
106MP0001188_hyperpigmentation0.65066734
107MP0001346_abnormal_lacrimal_gland0.64642333
108MP0004036_abnormal_muscle_relaxation0.64012994
109MP0005623_abnormal_meninges_morphology0.63262308
110MP0000013_abnormal_adipose_tissue0.62191308
111MP0006276_abnormal_autonomic_nervous0.61493138
112MP0005595_abnormal_vascular_smooth0.61310267
113MP0003283_abnormal_digestive_organ0.59564460
114MP0003045_fibrosis0.59213826
115MP0009384_cardiac_valve_regurgitation0.58181553
116MP0005535_abnormal_body_temperature0.57867495
117MP0001905_abnormal_dopamine_level0.57071681
118* MP0010769_abnormal_survival0.57058571
119MP0008874_decreased_physiological_sensi0.56652103
120MP0010770_preweaning_lethality0.55704038
121MP0002082_postnatal_lethality0.55704038
122MP0001943_abnormal_respiration0.55310895
123MP0004130_abnormal_muscle_cell0.54387346
124MP0000569_abnormal_digit_pigmentation0.53700206
125* MP0010768_mortality/aging0.53392994
126MP0005187_abnormal_penis_morphology0.51366187

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.71030308
2Central scotoma (HP:0000603)4.97177387
3Focal motor seizures (HP:0011153)4.89026648
4Progressive cerebellar ataxia (HP:0002073)4.77926238
5Action tremor (HP:0002345)4.42377749
6Epileptic encephalopathy (HP:0200134)4.41176013
7Visual hallucinations (HP:0002367)4.39036226
8Myokymia (HP:0002411)4.29970118
9Abnormality of macular pigmentation (HP:0008002)4.17665931
10Scotoma (HP:0000575)4.13648043
11Abnormal rod and cone electroretinograms (HP:0008323)4.09731429
12Megalencephaly (HP:0001355)4.05262892
13Focal seizures (HP:0007359)3.99877280
14Dysdiadochokinesis (HP:0002075)3.87872820
15Bony spicule pigmentary retinopathy (HP:0007737)3.84390553
16Hemiparesis (HP:0001269)3.77748332
17Hemiplegia (HP:0002301)3.69355048
18Febrile seizures (HP:0002373)3.50596693
19Supranuclear gaze palsy (HP:0000605)3.44864702
20Aplasia involving bones of the upper limbs (HP:0009823)3.44055802
21Aplasia of the phalanges of the hand (HP:0009802)3.44055802
22Aplasia involving bones of the extremities (HP:0009825)3.44055802
23Limb dystonia (HP:0002451)3.38028717
24Diplopia (HP:0000651)3.29783121
25Abnormality of binocular vision (HP:0011514)3.29783121
26Decreased central vision (HP:0007663)3.26637779
27Absence seizures (HP:0002121)3.24818445
28Absent rod-and cone-mediated responses on ERG (HP:0007688)3.23732957
29Peripheral hypomyelination (HP:0007182)3.21917340
30Severe visual impairment (HP:0001141)3.12146622
31Genetic anticipation (HP:0003743)3.09065717
32Generalized tonic-clonic seizures (HP:0002069)3.04494427
33Truncal ataxia (HP:0002078)3.02021121
34Gaze-evoked nystagmus (HP:0000640)3.01196740
35Depression (HP:0000716)3.01054942
36Postural instability (HP:0002172)2.98135036
37Annular pancreas (HP:0001734)2.96135379
38Obstructive sleep apnea (HP:0002870)2.92065770
39Dialeptic seizures (HP:0011146)2.92051361
40Abolished electroretinogram (ERG) (HP:0000550)2.88692381
41Increased circulating renin level (HP:0000848)2.88385917
42Atonic seizures (HP:0010819)2.84860828
43Cerebral hypomyelination (HP:0006808)2.82022765
44Intention tremor (HP:0002080)2.81259783
45Torticollis (HP:0000473)2.80494935
46Neurofibrillary tangles (HP:0002185)2.77463056
47Chorioretinal atrophy (HP:0000533)2.74180706
48Dyschromatopsia (HP:0007641)2.73027268
49Sleep apnea (HP:0010535)2.69229928
50Papilledema (HP:0001085)2.69158858
51Dysmetria (HP:0001310)2.67337332
52Status epilepticus (HP:0002133)2.62431009
53Abnormal eating behavior (HP:0100738)2.57644539
54Polyphagia (HP:0002591)2.55733781
55Hyperventilation (HP:0002883)2.55331972
56Abnormality of the corticospinal tract (HP:0002492)2.55082925
57Pendular nystagmus (HP:0012043)2.54542303
58Dysmetric saccades (HP:0000641)2.54098995
59Pigmentary retinal degeneration (HP:0001146)2.52364238
60Abnormality of ocular smooth pursuit (HP:0000617)2.52091851
61Impaired smooth pursuit (HP:0007772)2.49863116
62Ankle clonus (HP:0011448)2.48540544
63Scanning speech (HP:0002168)2.47351373
64Increased corneal curvature (HP:0100692)2.37742080
65Keratoconus (HP:0000563)2.37742080
66Macular degeneration (HP:0000608)2.36579526
67Anxiety (HP:0000739)2.36191288
68Abnormality of the lower motor neuron (HP:0002366)2.34684856
69Insomnia (HP:0100785)2.34565198
70Mutism (HP:0002300)2.33750280
71Akinesia (HP:0002304)2.33015086
72Broad-based gait (HP:0002136)2.32225140
73Focal dystonia (HP:0004373)2.30458291
74Ventricular fibrillation (HP:0001663)2.26493787
75Urinary urgency (HP:0000012)2.25313734
76Attenuation of retinal blood vessels (HP:0007843)2.24540121
77Tetraplegia (HP:0002445)2.21110963
78Morphological abnormality of the inner ear (HP:0011390)2.18278033
79Cerebral inclusion bodies (HP:0100314)2.17817589
80Poor eye contact (HP:0000817)2.16149053
81Delusions (HP:0000746)2.15529408
82Bradykinesia (HP:0002067)2.14874317
83Urinary bladder sphincter dysfunction (HP:0002839)2.14559622
84Choroideremia (HP:0001139)2.13018841
85Abnormal social behavior (HP:0012433)2.12200528
86Impaired social interactions (HP:0000735)2.12200528
87Posterior subcapsular cataract (HP:0007787)2.12010404
88Clumsiness (HP:0002312)2.11643668
89Spastic tetraparesis (HP:0001285)2.10226780
90Craniofacial dystonia (HP:0012179)2.08998675
91Degeneration of the lateral corticospinal tracts (HP:0002314)2.08371267
92Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.08371267
93Type II diabetes mellitus (HP:0005978)2.08193935
94Exercise-induced myalgia (HP:0003738)2.05534532
95Bronchomalacia (HP:0002780)2.05366420
96Clonus (HP:0002169)2.04497664
97Photophobia (HP:0000613)2.03079130
98Morphological abnormality of the pyramidal tract (HP:0002062)2.02753979
99Absent speech (HP:0001344)2.01426683
100Limb ataxia (HP:0002070)2.00011381
101EEG with generalized epileptiform discharges (HP:0011198)1.96144130
102Prolonged QT interval (HP:0001657)1.96025664
103Postural tremor (HP:0002174)1.93363433
104Amblyopia (HP:0000646)1.92677193
105Impaired vibration sensation in the lower limbs (HP:0002166)1.92402878
106Epileptiform EEG discharges (HP:0011182)1.92240680
107Abnormality of the diencephalon (HP:0010662)1.90952750
108CNS hypomyelination (HP:0003429)1.89715382
109Turricephaly (HP:0000262)1.89462250
110Choreoathetosis (HP:0001266)1.86190621
111Gait imbalance (HP:0002141)1.85833873
112Rigidity (HP:0002063)1.85464000
113Thickened helices (HP:0000391)1.85229694
114Abnormality of saccadic eye movements (HP:0000570)1.84592205
115Split foot (HP:0001839)1.80363010
116Confusion (HP:0001289)1.79964554
117Horizontal nystagmus (HP:0000666)1.79222203
118Retinitis pigmentosa (HP:0000510)1.79163297
119Spastic gait (HP:0002064)1.78948744
120Lower limb muscle weakness (HP:0007340)1.77744122
121Specific learning disability (HP:0001328)1.76582961
122Narrow nasal bridge (HP:0000446)1.76506042
123Incomplete penetrance (HP:0003829)1.75169368
124Hypsarrhythmia (HP:0002521)1.74596924
125Apathy (HP:0000741)1.74467281
126Neoplasm of the heart (HP:0100544)1.74059130
127Drooling (HP:0002307)1.73465618
128Excessive salivation (HP:0003781)1.73465618
129Lower limb asymmetry (HP:0100559)1.72853203
130Gait ataxia (HP:0002066)1.72424967
131Impaired vibratory sensation (HP:0002495)1.72022627
132Abnormal EKG (HP:0003115)1.71600740
133Cone-rod dystrophy (HP:0000548)1.71333456
134Metabolic alkalosis (HP:0200114)1.71320079
135Abnormality of cochlea (HP:0000375)1.70754471
136Stereotypic behavior (HP:0000733)1.69630049
137Neuronal loss in central nervous system (HP:0002529)1.69265415
138Pointed chin (HP:0000307)1.63777461
139Pheochromocytoma (HP:0002666)1.63694823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.28148307
2EPHA43.12558809
3NTRK22.96970371
4MAP3K42.82953164
5PHKG12.80016354
6PHKG22.80016354
7PAK62.59953793
8PRKD32.59223468
9MAP3K92.54657160
10LMTK22.52435069
11TNIK2.47835559
12MINK12.45524886
13MARK12.38807865
14STK382.14775867
15MAP2K72.05119608
16CAMKK12.02857377
17PINK11.91353590
18RIPK11.80452885
19PRPF4B1.74818939
20SGK4941.66533174
21SGK2231.66533174
22SGK21.59475846
23MAP2K41.52526793
24CAMKK21.52443628
25SGK31.45692649
26DAPK21.45682054
27PKN11.43276372
28PRKCG1.35618378
29CDK51.34552613
30WNK11.33433312
31KSR21.29435823
32NEK11.29155963
33MAPK131.25433542
34CAMK1G1.19955477
35NTRK11.18321853
36PRKCH1.16678495
37TYRO31.13141605
38DYRK1A1.09486657
39MAPK121.03537864
40CAMK11.00002857
41SIK20.98950532
42GRK50.95635827
43KSR10.94942820
44MUSK0.93056462
45NEK60.91551354
46CDK190.91434872
47LATS20.91167375
48CDK150.90792880
49CDC42BPA0.88721312
50CDK180.87341563
51TRIB30.86458788
52TNK20.84987117
53PLK20.84835896
54CASK0.83471340
55CDK140.81864104
56ARAF0.81751053
57UHMK10.81506969
58GRK10.80144982
59SGK10.80022759
60STK110.79911698
61CDK11A0.79538004
62FES0.78887627
63CAMK2A0.78236068
64PNCK0.77056979
65DYRK20.76839771
66MAP3K130.75785991
67CSNK1G20.75163993
68MAP3K70.74974521
69SIK10.74715861
70ALK0.73790034
71TAOK20.70273613
72PAK30.68078638
73RPS6KA30.67787519
74RET0.67421792
75CAMK1D0.66519517
76MAPK150.66159915
77CAMK2D0.65564906
78ROCK20.65018121
79CAMK2G0.63979762
80BRSK10.63168990
81IRAK20.61832041
82DAPK10.59577226
83ICK0.59390063
84MAPK100.59321790
85PRKAA10.59231791
86CAMK40.58394828
87WNK30.56034610
88CCNB10.55577464
89OXSR10.55440670
90BMX0.55343318
91TAOK10.53814314
92RAF10.53690908
93MAPKAPK50.52147962
94MAPK70.51038322
95ROCK10.50908335
96PRKCZ0.50245026
97MARK20.49984640
98CDK30.48308714
99RIPK40.48209056
100PRKCE0.47528516
101CAMK2B0.47237645
102PDK10.45296178
103PRKCB0.44878509
104ERBB20.44201451
105PRKG10.43523384
106PRKCA0.42811390
107ADRBK10.42272139
108MAP3K20.41949927
109PRKACG0.41599227
110DMPK0.40989724
111GSK3B0.40553314
112FGFR20.40537228
113FGFR10.40100735
114STK390.37336020
115PRKACA0.36531612
116CSNK1A10.35639298
117LIMK10.34603975
118CSNK1A1L0.34487172
119FYN0.34107036
120CSNK1G30.33740532
121PRKDC0.32428374
122CSNK1D0.32251408
123MAPK40.31547975
124CSNK1G10.28056433
125CSNK1E0.27717430

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.68849000
2Nitrogen metabolism_Homo sapiens_hsa009103.67530037
3Phototransduction_Homo sapiens_hsa047443.38559303
4GABAergic synapse_Homo sapiens_hsa047273.06476258
5Synaptic vesicle cycle_Homo sapiens_hsa047213.06411397
6Glutamatergic synapse_Homo sapiens_hsa047242.62795649
7Circadian entrainment_Homo sapiens_hsa047132.54602104
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53858984
9Morphine addiction_Homo sapiens_hsa050322.44885851
10Olfactory transduction_Homo sapiens_hsa047402.30988023
11Long-term potentiation_Homo sapiens_hsa047202.01790097
12* Salivary secretion_Homo sapiens_hsa049701.95654584
13* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93494857
14* Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.93082950
15* Insulin secretion_Homo sapiens_hsa049111.90249385
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66595655
17Fatty acid biosynthesis_Homo sapiens_hsa000611.66359021
18Amphetamine addiction_Homo sapiens_hsa050311.65942999
19Cholinergic synapse_Homo sapiens_hsa047251.65185675
20Dopaminergic synapse_Homo sapiens_hsa047281.64203621
21* Gastric acid secretion_Homo sapiens_hsa049711.63618664
22Taste transduction_Homo sapiens_hsa047421.51170292
23* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48029647
24Long-term depression_Homo sapiens_hsa047301.47944255
25Circadian rhythm_Homo sapiens_hsa047101.47001670
26Renin secretion_Homo sapiens_hsa049241.46865549
27Calcium signaling pathway_Homo sapiens_hsa040201.43004034
28Oxytocin signaling pathway_Homo sapiens_hsa049211.41833083
29Vitamin B6 metabolism_Homo sapiens_hsa007501.34642902
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30661234
31Serotonergic synapse_Homo sapiens_hsa047261.26459292
32Cocaine addiction_Homo sapiens_hsa050301.25745224
33* cAMP signaling pathway_Homo sapiens_hsa040241.22915106
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20394718
35* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15903932
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15228544
37Gap junction_Homo sapiens_hsa045401.12840172
38GnRH signaling pathway_Homo sapiens_hsa049121.12287784
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08977509
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04763748
41Type II diabetes mellitus_Homo sapiens_hsa049301.04737286
42* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98793580
43Dilated cardiomyopathy_Homo sapiens_hsa054140.97023240
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94998259
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.92786930
46Prion diseases_Homo sapiens_hsa050200.87920080
47* Cardiac muscle contraction_Homo sapiens_hsa042600.86028345
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85284946
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84759628
50* Pancreatic secretion_Homo sapiens_hsa049720.84375815
51Dorso-ventral axis formation_Homo sapiens_hsa043200.83218375
52Estrogen signaling pathway_Homo sapiens_hsa049150.83035567
53Melanogenesis_Homo sapiens_hsa049160.80941563
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77710560
55* Bile secretion_Homo sapiens_hsa049760.77277067
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.76203521
57* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75420381
58Glioma_Homo sapiens_hsa052140.72481050
59Histidine metabolism_Homo sapiens_hsa003400.68821206
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68404161
61beta-Alanine metabolism_Homo sapiens_hsa004100.67552131
62Inositol phosphate metabolism_Homo sapiens_hsa005620.65672941
63ErbB signaling pathway_Homo sapiens_hsa040120.65468028
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64881160
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64119252
66Glucagon signaling pathway_Homo sapiens_hsa049220.64077017
67* Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63697993
68Arginine and proline metabolism_Homo sapiens_hsa003300.63681995
69Axon guidance_Homo sapiens_hsa043600.62024597
70Choline metabolism in cancer_Homo sapiens_hsa052310.61591023
71* Thyroid hormone synthesis_Homo sapiens_hsa049180.59941071
72Collecting duct acid secretion_Homo sapiens_hsa049660.59782636
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58895583
74Vibrio cholerae infection_Homo sapiens_hsa051100.58102685
75MAPK signaling pathway_Homo sapiens_hsa040100.57283847
76mTOR signaling pathway_Homo sapiens_hsa041500.56640313
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.52767314
78Fructose and mannose metabolism_Homo sapiens_hsa000510.52310510
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51657303
80Oocyte meiosis_Homo sapiens_hsa041140.51605955
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50297926
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.49944665
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49642934
84Fatty acid metabolism_Homo sapiens_hsa012120.49158341
85Butanoate metabolism_Homo sapiens_hsa006500.47810813
86Hippo signaling pathway_Homo sapiens_hsa043900.47612420
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.46142437
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40795613
89Arginine biosynthesis_Homo sapiens_hsa002200.40774346
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40639644
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.40116415
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39859543
93Alzheimers disease_Homo sapiens_hsa050100.39717303
94Insulin signaling pathway_Homo sapiens_hsa049100.39119153
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38539896
96Endocytosis_Homo sapiens_hsa041440.37522640
97Rap1 signaling pathway_Homo sapiens_hsa040150.35375460
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.35288591
99Ras signaling pathway_Homo sapiens_hsa040140.35077291
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35064271
101Ovarian steroidogenesis_Homo sapiens_hsa049130.34751062
102Wnt signaling pathway_Homo sapiens_hsa043100.32720376
103Renal cell carcinoma_Homo sapiens_hsa052110.32454665
104Alcoholism_Homo sapiens_hsa050340.32346245
105Endometrial cancer_Homo sapiens_hsa052130.32320507
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30966811
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30153125
108Tight junction_Homo sapiens_hsa045300.29485324
109Hedgehog signaling pathway_Homo sapiens_hsa043400.28951592
110Biosynthesis of amino acids_Homo sapiens_hsa012300.27965610
111* Mineral absorption_Homo sapiens_hsa049780.26050516
112VEGF signaling pathway_Homo sapiens_hsa043700.25249193
113Basal cell carcinoma_Homo sapiens_hsa052170.22381165
114AMPK signaling pathway_Homo sapiens_hsa041520.21621974

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »