ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.37463674
2	positive regulation of protein homooligomerization (GO:0032464)	5.15137743
3	transcription from mitochondrial promoter (GO:0006390)	5.08155796
4	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.92547282
5	male meiosis I (GO:0007141)	4.67876539
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.58682837
7	termination of RNA polymerase III transcription (GO:0006386)	4.37597620
8	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.37597620
9	iron-sulfur cluster assembly (GO:0016226)	4.36418311
10	metallo-sulfur cluster assembly (GO:0031163)	4.36418311
11	chaperone-mediated protein transport (GO:0072321)	4.34488590
12	meiosis I (GO:0007127)	4.34382102
13	cytidine metabolic process (GO:0046087)	4.27753831
14	cytidine catabolic process (GO:0006216)	4.27753831
15	cytidine deamination (GO:0009972)	4.27753831
16	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.09843866
17	rRNA modification (GO:0000154)	4.09486095
18	regulation of uterine smooth muscle contraction (GO:0070472)	3.94606649
19	piRNA metabolic process (GO:0034587)	3.88117062
20	mitochondrial DNA replication (GO:0006264)	3.87256181
21	negative regulation by host of viral transcription (GO:0043922)	3.70411809
22	maturation of 5.8S rRNA (GO:0000460)	3.68151750
23	kynurenine metabolic process (GO:0070189)	3.58997816
24	NAD biosynthetic process (GO:0009435)	3.56115119
25	proteasome assembly (GO:0043248)	3.54059894
26	inner mitochondrial membrane organization (GO:0007007)	3.51647920
27	male meiosis (GO:0007140)	3.51238062
28	indole-containing compound catabolic process (GO:0042436)	3.47415747
29	indolalkylamine catabolic process (GO:0046218)	3.47415747
30	tryptophan catabolic process (GO:0006569)	3.47415747
31	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.40291904
32	regulation of regulatory T cell differentiation (GO:0045589)	3.39421724
33	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.36817087
34	cytolysis (GO:0019835)	3.34490465
35	regulation of G0 to G1 transition (GO:0070316)	3.25353903
36	gonadal mesoderm development (GO:0007506)	3.22884341
37	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.17611751
38	GDP-mannose metabolic process (GO:0019673)	3.14925746
39	cytochrome complex assembly (GO:0017004)	3.13153985
40	histone mRNA metabolic process (GO:0008334)	3.11277306
41	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.09836257
42	positive regulation of translational initiation (GO:0045948)	3.08826360
43	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.07661270
44	negative regulation of T cell differentiation in thymus (GO:0033085)	3.04552484
45	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.03947305
46	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.00693543
47	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.99005089
48	isotype switching (GO:0045190)	2.99005089
49	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.99005089
50	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.98547616
51	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.96796550
52	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.96796550
53	positive regulation of T cell apoptotic process (GO:0070234)	2.95522228
54	mitochondrial RNA metabolic process (GO:0000959)	2.95134208
55	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.94006054
56	negative regulation of thymocyte apoptotic process (GO:0070244)	2.92974301
57	eosinophil chemotaxis (GO:0048245)	2.88158807
58	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.87542887
59	positive regulation of protein oligomerization (GO:0032461)	2.86943530
60	regulation of mitochondrial translation (GO:0070129)	2.86825027
61	regulation of cellular amino acid metabolic process (GO:0006521)	2.84529332
62	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.84272273
63	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.84272273
64	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.84272273
65	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.83485014
66	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.82950046
67	regulation of thymocyte apoptotic process (GO:0070243)	2.82456420
68	positive regulation of chromosome segregation (GO:0051984)	2.82256558
69	regulation of protein homooligomerization (GO:0032462)	2.79292678
70	positive regulation of interleukin-8 secretion (GO:2000484)	2.79214227
71	positive regulation of prostaglandin secretion (GO:0032308)	2.79132104
72	actin nucleation (GO:0045010)	2.76997572
73	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.75320804
74	histone mRNA catabolic process (GO:0071044)	2.75130503
75	positive regulation of humoral immune response (GO:0002922)	2.74993551
76	pseudouridine synthesis (GO:0001522)	2.74392251
77	somatic diversification of immunoglobulins (GO:0016445)	2.73228977
78	protein deneddylation (GO:0000338)	2.72651270
79	response to UV-C (GO:0010225)	2.71199185
80	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.71062448
81	negative regulation of ligase activity (GO:0051352)	2.71062448
82	negative regulation of T cell apoptotic process (GO:0070233)	2.70297988
83	protein kinase C signaling (GO:0070528)	2.67495422
84	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.65987551
85	macrophage chemotaxis (GO:0048246)	2.65632917
86	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.65315672
87	nicotinamide nucleotide biosynthetic process (GO:0019359)	2.65228608
88	pyridine nucleotide biosynthetic process (GO:0019363)	2.65228608
89	DNA methylation involved in gamete generation (GO:0043046)	2.64521671
90	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.64359767
91	ribosome biogenesis (GO:0042254)	2.64342241
92	viral mRNA export from host cell nucleus (GO:0046784)	2.63342829
93	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.62977234
94	protein homotrimerization (GO:0070207)	2.61748443
95	mannosylation (GO:0097502)	2.60768237
96	eosinophil migration (GO:0072677)	2.57952812
97	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.57635692
98	protein complex biogenesis (GO:0070271)	2.56040390
99	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	15.6062304
100	regulation of retinoic acid receptor signaling pathway (GO:0048385)	13.2723983

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.42810368
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.40080386
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.21986029
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.81719240
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.61228248
6	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.38595800
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.38021717
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.26520627
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.22946673
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.06756910
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.01272727
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.55581805
13	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.53707127
14	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.53656940
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.40658242
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.38233633
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.35995905
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.34711819
19	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.26882250
20	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.15527855
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.12527414
22	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.09127271
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.94791889
24	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.93157108
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89349506
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.84202206
27	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.81736823
28	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.81511168
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.77262387
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.76398765
31	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.75652481
32	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.74911807
33	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.74911807
34	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.74911807
35	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.72806311
36	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.66112779
37	DCP1A_22483619_ChIP-Seq_HELA_Human	1.64328085
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.64286763
39	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.60469137
40	GABP_19822575_ChIP-Seq_HepG2_Human	1.56540810
41	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.55265545
42	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.49720134
43	EZH2_22144423_ChIP-Seq_EOC_Human	1.47036859
44	MYC_18940864_ChIP-ChIP_HL60_Human	1.46299391
45	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.46104392
46	E2F7_22180533_ChIP-Seq_HELA_Human	1.45199497
47	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.44615044
48	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.41857996
49	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.40818143
50	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.40110979
51	TTF2_22483619_ChIP-Seq_HELA_Human	1.38549009
52	VDR_22108803_ChIP-Seq_LS180_Human	1.37696573
53	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.31564837
54	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.31285787
55	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.30295455
56	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.28875620
57	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.28862347
58	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.28667984
59	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.25835420
60	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19505654
61	GATA3_26560356_Chip-Seq_TH2_Human	1.18419461
62	STAT1_20625510_ChIP-Seq_HELA_Human	1.17835853
63	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.15911665
64	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.15615535
65	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.13948121
66	MYB_26560356_Chip-Seq_TH2_Human	1.12385149
67	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.10437256
68	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.10410782
69	CTCF_20526341_ChIP-Seq_ESCs_Human	1.08623270
70	ELK1_19687146_ChIP-ChIP_HELA_Human	1.06668092
71	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.05653155
72	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05218061
73	PHF8_20622853_ChIP-Seq_HELA_Human	1.04501418
74	GATA3_26560356_Chip-Seq_TH1_Human	1.03900588
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.00377899
76	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.00249008
77	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99128918
78	RAC3_21632823_ChIP-Seq_H3396_Human	0.97445337
79	RBPJ_21746931_ChIP-Seq_IB4_Human	0.96318582
80	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95878067
81	ERA_21632823_ChIP-Seq_H3396_Human	0.95817704
82	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.94760395
83	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.93727452
84	TAF2_19829295_ChIP-Seq_ESCs_Human	0.93633888
85	HOXB7_26014856_ChIP-Seq_BT474_Human	0.93180837
86	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.92397277
87	OCT4_20526341_ChIP-Seq_ESCs_Human	0.91372208
88	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.90981662
89	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.90752534
90	HTT_18923047_ChIP-ChIP_STHdh_Human	0.90554897
91	P53_21459846_ChIP-Seq_SAOS-2_Human	0.89529250
92	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.89196435
93	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.88325480
94	IRF1_19129219_ChIP-ChIP_H3396_Human	0.88318412
95	P300_27268052_Chip-Seq_Bcells_Human	0.87420605
96	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.87098345
97	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.86349176
98	NCOR_22424771_ChIP-Seq_293T_Human	0.85392933
99	ETV1_20927104_ChIP-Seq_GIST48_Human	0.85152431
100	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.84691287

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.73044218
2	MP0008875_abnormal_xenobiotic_pharmacok	3.86632093
3	MP0001986_abnormal_taste_sensitivity	3.37161841
4	MP0005423_abnormal_somatic_nervous	3.30790046
5	MP0003693_abnormal_embryo_hatching	3.14298509
6	MP0006292_abnormal_olfactory_placode	2.90947061
7	MP0002234_abnormal_pharynx_morphology	2.79766962
8	MP0009333_abnormal_splenocyte_physiolog	2.71822422
9	MP0003866_abnormal_defecation	2.31486963
10	MP0002160_abnormal_reproductive_system	2.30434418
11	MP0002138_abnormal_hepatobiliary_system	2.29490849
12	MP0003763_abnormal_thymus_physiology	2.20148170
13	MP0003718_maternal_effect	2.17023062
14	MP0008058_abnormal_DNA_repair	2.07688939
15	MP0010094_abnormal_chromosome_stability	2.01030844
16	MP0005410_abnormal_fertilization	1.98815264
17	MP0003950_abnormal_plasma_membrane	1.97235981
18	MP0003111_abnormal_nucleus_morphology	1.97049534
19	MP0004957_abnormal_blastocyst_morpholog	1.87420027
20	MP0005167_abnormal_blood-brain_barrier	1.86002067
21	MP0001835_abnormal_antigen_presentation	1.85005957
22	MP0002102_abnormal_ear_morphology	1.82476495
23	MP0008877_abnormal_DNA_methylation	1.78901255
24	MP0010155_abnormal_intestine_physiology	1.71810023
25	MP0003252_abnormal_bile_duct	1.71197653
26	MP0009785_altered_susceptibility_to	1.70563085
27	MP0006082_CNS_inflammation	1.67966364
28	MP0003646_muscle_fatigue	1.67784111
29	MP0002277_abnormal_respiratory_mucosa	1.61903181
30	MP0004147_increased_porphyrin_level	1.61851825
31	MP0003786_premature_aging	1.61605522
32	MP0005389_reproductive_system_phenotype	1.61139064
33	MP0003077_abnormal_cell_cycle	1.55942538
34	MP0010368_abnormal_lymphatic_system	1.55311108
35	MP0001929_abnormal_gametogenesis	1.54544878
36	MP0002148_abnormal_hypersensitivity_rea	1.41296614
37	MP0005647_abnormal_sex_gland	1.40170803
38	MP0006036_abnormal_mitochondrial_physio	1.38064524
39	MP0003806_abnormal_nucleotide_metabolis	1.35533364
40	MP0002210_abnormal_sex_determination	1.32523433
41	MP0002166_altered_tumor_susceptibility	1.30560148
42	MP0008007_abnormal_cellular_replicative	1.29877721
43	MP0005377_hearing/vestibular/ear_phenot	1.28688236
44	MP0003878_abnormal_ear_physiology	1.28688236
45	MP0005387_immune_system_phenotype	1.25388076
46	MP0001790_abnormal_immune_system	1.25388076
47	MP0000490_abnormal_crypts_of	1.25123445
48	MP0006035_abnormal_mitochondrial_morpho	1.15502222
49	MP0000678_abnormal_parathyroid_gland	1.14506116
50	MP0008932_abnormal_embryonic_tissue	1.13402314
51	MP0001800_abnormal_humoral_immune	1.13169528
52	MP0002006_tumorigenesis	1.12366463
53	MP0001666_abnormal_nutrient_absorption	1.10581630
54	MP0002420_abnormal_adaptive_immunity	1.10463690
55	MP0001819_abnormal_immune_cell	1.08320771
56	MP0005000_abnormal_immune_tolerance	1.05965592
57	MP0002933_joint_inflammation	1.03969501
58	MP0001968_abnormal_touch/_nociception	1.02951131
59	MP0000049_abnormal_middle_ear	1.02859627
60	MP0003567_abnormal_fetal_cardiomyocyte	1.02381510
61	MP0008789_abnormal_olfactory_epithelium	1.02001657
62	MP0000653_abnormal_sex_gland	1.00978339
63	MP0003011_delayed_dark_adaptation	0.98803433
64	MP0002723_abnormal_immune_serum	0.97783381
65	MP0009379_abnormal_foot_pigmentation	0.96405694
66	MP0001873_stomach_inflammation	0.96009343
67	MP0002127_abnormal_cardiovascular_syste	0.95006511
68	MP0002736_abnormal_nociception_after	0.94021795
69	MP0001145_abnormal_male_reproductive	0.93077287
70	MP0003119_abnormal_digestive_system	0.92974473
71	MP0003698_abnormal_male_reproductive	0.91833155
72	MP0005499_abnormal_olfactory_system	0.90722326
73	MP0005394_taste/olfaction_phenotype	0.90722326
74	MP0002452_abnormal_antigen_presenting	0.89738662
75	MP0005083_abnormal_biliary_tract	0.87873969
76	MP0000689_abnormal_spleen_morphology	0.86501809
77	MP0003186_abnormal_redox_activity	0.86207548
78	MP0005025_abnormal_response_to	0.85136886
79	MP0002722_abnormal_immune_system	0.82705418
80	MP0001905_abnormal_dopamine_level	0.81982691
81	MP0000716_abnormal_immune_system	0.81081876
82	MP0003137_abnormal_impulse_conducting	0.79979113
83	MP0001485_abnormal_pinna_reflex	0.78623509
84	MP0001919_abnormal_reproductive_system	0.77962266
85	MP0005085_abnormal_gallbladder_physiolo	0.76353936
86	MP0003724_increased_susceptibility_to	0.75419861
87	MP0009840_abnormal_foam_cell	0.74297565
88	MP0001119_abnormal_female_reproductive	0.74203328
89	MP0002751_abnormal_autonomic_nervous	0.74147102
90	MP0002398_abnormal_bone_marrow	0.73633055
91	MP0001845_abnormal_inflammatory_respons	0.73436324
92	MP0009764_decreased_sensitivity_to	0.72338820
93	MP0000703_abnormal_thymus_morphology	0.72241851
94	MP0002405_respiratory_system_inflammati	0.70459571
95	MP0001346_abnormal_lacrimal_gland	0.69513950
96	MP0002396_abnormal_hematopoietic_system	0.68504560
97	MP0010307_abnormal_tumor_latency	0.68412220
98	MP0000313_abnormal_cell_death	0.67988280
99	MP0002161_abnormal_fertility/fecundity	0.67890573
100	MP0002429_abnormal_blood_cell	0.67528281

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Testicular atrophy (HP:0000029)	5.75131371
2	Autoimmune thrombocytopenia (HP:0001973)	5.11850343
3	Tetraparesis (HP:0002273)	4.30413792
4	Autoimmune hemolytic anemia (HP:0001890)	4.27077226
5	3-Methylglutaconic aciduria (HP:0003535)	3.87968821
6	Increased IgM level (HP:0003496)	3.68528157
7	IgG deficiency (HP:0004315)	3.57283725
8	Bile duct proliferation (HP:0001408)	3.44339735
9	Abnormal biliary tract physiology (HP:0012439)	3.44339735
10	Abnormality of T cell physiology (HP:0011840)	3.11335085
11	Prostate neoplasm (HP:0100787)	3.08152014
12	Stomatitis (HP:0010280)	3.07446681
13	Hypoproteinemia (HP:0003075)	3.04628933
14	Mitochondrial inheritance (HP:0001427)	2.96831759
15	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.92782874
16	Dysphonia (HP:0001618)	2.90003478
17	Premature ovarian failure (HP:0008209)	2.82751690
18	Acute necrotizing encephalopathy (HP:0006965)	2.81928450
19	Renal Fanconi syndrome (HP:0001994)	2.78889248
20	Supernumerary spleens (HP:0009799)	2.69900346
21	Myopathic facies (HP:0002058)	2.69464618
22	Abnormality of B cell number (HP:0010975)	2.68073623
23	Increased CSF lactate (HP:0002490)	2.67564238
24	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.65927650
25	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.64320579
26	Increased hepatocellular lipid droplets (HP:0006565)	2.57526601
27	Abnormality of T cells (HP:0002843)	2.56300821
28	Aplasia/hypoplasia of the uterus (HP:0008684)	2.56102008
29	Abnormal mitochondria in muscle tissue (HP:0008316)	2.54898426
30	Posterior subcapsular cataract (HP:0007787)	2.52517141
31	Sensory axonal neuropathy (HP:0003390)	2.52363263
32	Impulsivity (HP:0100710)	2.51341042
33	Congenital malformation of the right heart (HP:0011723)	2.50409491
34	Double outlet right ventricle (HP:0001719)	2.50409491
35	Pancreatic fibrosis (HP:0100732)	2.47551955
36	Pancreatic cysts (HP:0001737)	2.46044652
37	Microretrognathia (HP:0000308)	2.43440093
38	Hypoplasia of the uterus (HP:0000013)	2.43232602
39	Spastic paraparesis (HP:0002313)	2.43041948
40	IgM deficiency (HP:0002850)	2.42608865
41	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.40359010
42	Abnormality of the prostate (HP:0008775)	2.37698807
43	Redundant skin (HP:0001582)	2.37301295
44	Progressive macrocephaly (HP:0004481)	2.35887592
45	Dysautonomia (HP:0002459)	2.35311288
46	Male infertility (HP:0003251)	2.31977219
47	Short tibia (HP:0005736)	2.29840093
48	Type I transferrin isoform profile (HP:0003642)	2.29153985
49	Visual hallucinations (HP:0002367)	2.28319883
50	Abnormal spermatogenesis (HP:0008669)	2.28268487
51	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.26046857
52	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.26046857
53	Microvesicular hepatic steatosis (HP:0001414)	2.23936434
54	Increased serum lactate (HP:0002151)	2.22671819
55	Acute encephalopathy (HP:0006846)	2.22285890
56	Abnormality of midbrain morphology (HP:0002418)	2.20525294
57	Molar tooth sign on MRI (HP:0002419)	2.20525294
58	Abnormality of abdominal situs (HP:0011620)	2.20246817
59	Abdominal situs inversus (HP:0003363)	2.20246817
60	Type 2 muscle fiber atrophy (HP:0003554)	2.20011378
61	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.18883011
62	Malnutrition (HP:0004395)	2.17263901
63	Glycosuria (HP:0003076)	2.13109948
64	Abnormality of urine glucose concentration (HP:0011016)	2.13109948
65	Abnormal rod and cone electroretinograms (HP:0008323)	2.12042922
66	Lipid accumulation in hepatocytes (HP:0006561)	2.10394956
67	Concave nail (HP:0001598)	2.08014462
68	Aplastic anemia (HP:0001915)	2.07364558
69	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.06249733
70	Pancytopenia (HP:0001876)	2.05770616
71	Progressive external ophthalmoplegia (HP:0000590)	2.05335493
72	Increased intramyocellular lipid droplets (HP:0012240)	2.03510060
73	Horseshoe kidney (HP:0000085)	2.02658842
74	B lymphocytopenia (HP:0010976)	2.01820184
75	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.01506380
76	Amaurosis fugax (HP:0100576)	2.00104866
77	Rough bone trabeculation (HP:0100670)	1.99250717
78	Azoospermia (HP:0000027)	1.99153616
79	Dyschromatopsia (HP:0007641)	1.98781322
80	Delusions (HP:0000746)	1.98441958
81	Lymphopenia (HP:0001888)	1.96670938
82	Exertional dyspnea (HP:0002875)	1.91271065
83	Fibular aplasia (HP:0002990)	1.90330651
84	Patent foramen ovale (HP:0001655)	1.88892257
85	Lymphoma (HP:0002665)	1.88654248
86	Sclerocornea (HP:0000647)	1.88349707
87	Hepatocellular necrosis (HP:0001404)	1.87066944
88	Impaired proprioception (HP:0010831)	1.84403003
89	Muscle fiber atrophy (HP:0100295)	1.84322270
90	Abnormality of cells of the lymphoid lineage (HP:0012140)	1.83704603
91	Multiple enchondromatosis (HP:0005701)	1.83402564
92	Cellular immunodeficiency (HP:0005374)	1.83136937
93	Cerebral edema (HP:0002181)	1.82789266
94	Hypophosphatemic rickets (HP:0004912)	1.81570881
95	Ependymoma (HP:0002888)	1.81281648
96	Tubulointerstitial fibrosis (HP:0005576)	1.81222956
97	Hypergonadotropic hypogonadism (HP:0000815)	1.81027286
98	Increased cerebral lipofuscin (HP:0011813)	1.80116233
99	Exercise intolerance (HP:0003546)	1.79868380
100	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.79403898

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	6.89634121
2	ZAK	4.02856371
3	BUB1	4.01552165
4	KDR	3.39838870
5	TESK2	3.24620084
6	TXK	2.86642252
7	STK16	2.63704359
8	ADRBK2	2.55259440
9	TRIM28	2.34377091
10	NUAK1	2.16856179
11	GRK1	2.14059213
12	MAP4K1	2.12452939
13	BCKDK	1.87511086
14	SRPK1	1.86664884
15	VRK2	1.84041953
16	NEK1	1.65449249
17	TAOK3	1.65375125
18	EIF2AK3	1.62915641
19	GRK7	1.52364967
20	FES	1.51381807
21	BMPR1B	1.50196094
22	PLK3	1.47556403
23	EIF2AK1	1.45900553
24	SCYL2	1.45304587
25	TLK1	1.39753395
26	TEC	1.39687544
27	VRK1	1.38905332
28	MAP3K12	1.37736294
29	TESK1	1.32696758
30	TGFBR2	1.26184925
31	BRSK1	1.24077879
32	MAP4K2	1.22773926
33	FRK	1.17142995
34	CHEK2	1.02469950
35	WNK4	0.99426863
36	PLK1	0.96236432
37	ITK	0.89206357
38	AURKA	0.88411803
39	BRSK2	0.87749245
40	PIK3CA	0.84766948
41	WNK3	0.79441187
42	CSNK1A1L	0.77846732
43	CSNK1G3	0.76910236
44	GRK5	0.74337767
45	PAK6	0.73996042
46	CSNK1G1	0.69385184
47	EIF2AK2	0.69066526
48	MAP3K5	0.68174434
49	TTK	0.66762960
50	JAK3	0.66057957
51	GSK3A	0.65667675
52	CSNK1A1	0.65574762
53	TAF1	0.65334068
54	LIMK1	0.64315698
55	AURKB	0.63448525
56	PLK4	0.62750212
57	CSK	0.62361520
58	MST4	0.61085586
59	PIM2	0.60189570
60	TBK1	0.60162523
61	CDK9	0.59623075
62	PLK2	0.59552448
63	PRKCI	0.59445588
64	MELK	0.58691766
65	PIM1	0.58006635
66	CSNK2A1	0.57250383
67	RPS6KA5	0.55923376
68	INSRR	0.53025597
69	LCK	0.49837666
70	TGFBR1	0.48743599
71	MYLK	0.48149212
72	PNCK	0.46175711
73	LYN	0.45853287
74	SYK	0.44897715
75	CSNK1G2	0.44362864
76	ZAP70	0.43221170
77	ATR	0.42431260
78	CSNK2A2	0.37204357
79	PIK3CG	0.36998748
80	CHEK1	0.36661015
81	BLK	0.36206865
82	IKBKE	0.33190084
83	PAK1	0.32398628
84	CDK7	0.32022436
85	ACVR1B	0.30772114
86	NEK6	0.29605339
87	IGF1R	0.28635659
88	ATM	0.28196193
89	WEE1	0.26939252
90	IKBKB	0.26679246
91	ADRBK1	0.26676126
92	TAOK2	0.26559352
93	MAP3K11	0.25735189
94	AKT2	0.25424595
95	PRKCQ	0.25089794
96	PRKCA	0.25066198
97	CAMK2D	0.23774010
98	CAMK2G	0.23061263
99	PBK	0.21069120
100	DYRK2	0.21035135

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	7.07694437
2	Proteasome_Homo sapiens_hsa03050	4.01387133
3	RNA polymerase_Homo sapiens_hsa03020	3.32950266
4	Primary immunodeficiency_Homo sapiens_hsa05340	3.03801138
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.64387375
6	Ribosome_Homo sapiens_hsa03010	2.51881809
7	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.36163326
8	Allograft rejection_Homo sapiens_hsa05330	2.21912003
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.15936099
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.01210936
11	Parkinsons disease_Homo sapiens_hsa05012	1.89668375
12	Protein export_Homo sapiens_hsa03060	1.86477764
13	Basal transcription factors_Homo sapiens_hsa03022	1.84593073
14	Rheumatoid arthritis_Homo sapiens_hsa05323	1.69706622
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.68684764
16	Graft-versus-host disease_Homo sapiens_hsa05332	1.67091291
17	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.62880723
18	RNA transport_Homo sapiens_hsa03013	1.61594638
19	Spliceosome_Homo sapiens_hsa03040	1.60355999
20	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.46902885
21	Huntingtons disease_Homo sapiens_hsa05016	1.43127893
22	Mismatch repair_Homo sapiens_hsa03430	1.40837502
23	Regulation of autophagy_Homo sapiens_hsa04140	1.38441057
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.38213560
25	Asthma_Homo sapiens_hsa05310	1.37731730
26	Homologous recombination_Homo sapiens_hsa03440	1.37373227
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.35774191
28	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.34589982
29	Type I diabetes mellitus_Homo sapiens_hsa04940	1.28318828
30	RNA degradation_Homo sapiens_hsa03018	1.24627276
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.23052879
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.20603341
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.20218735
34	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.18775414
35	Alzheimers disease_Homo sapiens_hsa05010	1.18028064
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.16414841
37	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.15025600
38	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.09360428
39	Purine metabolism_Homo sapiens_hsa00230	1.02417986
40	One carbon pool by folate_Homo sapiens_hsa00670	1.01402987
41	Linoleic acid metabolism_Homo sapiens_hsa00591	0.96635592
42	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.96284628
43	DNA replication_Homo sapiens_hsa03030	0.90494334
44	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.88546934
45	mRNA surveillance pathway_Homo sapiens_hsa03015	0.83401035
46	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.82324166
47	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.81786406
48	Phototransduction_Homo sapiens_hsa04744	0.81313390
49	Viral myocarditis_Homo sapiens_hsa05416	0.81157144
50	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.77920577
51	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.76181385
52	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.74345797
53	p53 signaling pathway_Homo sapiens_hsa04115	0.74068298
54	Sulfur metabolism_Homo sapiens_hsa00920	0.72248889
55	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.68540020
56	Herpes simplex infection_Homo sapiens_hsa05168	0.67152478
57	Oocyte meiosis_Homo sapiens_hsa04114	0.66978650
58	Retinol metabolism_Homo sapiens_hsa00830	0.66419649
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65759040
60	Cell cycle_Homo sapiens_hsa04110	0.64145871
61	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.63496691
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.63441707
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.63302740
64	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.63039544
65	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.62701940
66	Nucleotide excision repair_Homo sapiens_hsa03420	0.62003627
67	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.61646932
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.60065056
69	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.59822893
70	Glutathione metabolism_Homo sapiens_hsa00480	0.58405859
71	Steroid biosynthesis_Homo sapiens_hsa00100	0.55771650
72	Folate biosynthesis_Homo sapiens_hsa00790	0.53650584
73	Mineral absorption_Homo sapiens_hsa04978	0.52307634
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.49925686
75	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.49262856
76	Metabolic pathways_Homo sapiens_hsa01100	0.48645945
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.48533359
78	Measles_Homo sapiens_hsa05162	0.46972219
79	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.45621810
80	Peroxisome_Homo sapiens_hsa04146	0.45406035
81	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.44592022
82	Viral carcinogenesis_Homo sapiens_hsa05203	0.44384630
83	Ether lipid metabolism_Homo sapiens_hsa00565	0.43542028
84	Base excision repair_Homo sapiens_hsa03410	0.32299262
85	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.31390264
86	Fatty acid elongation_Homo sapiens_hsa00062	0.30989118
87	Legionellosis_Homo sapiens_hsa05134	0.30548506
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.29411262
89	Apoptosis_Homo sapiens_hsa04210	0.28267995
90	Olfactory transduction_Homo sapiens_hsa04740	0.28007947
91	Malaria_Homo sapiens_hsa05144	0.27996181
92	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.27430166
93	Taste transduction_Homo sapiens_hsa04742	0.25777278
94	HTLV-I infection_Homo sapiens_hsa05166	0.25588165
95	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.24801109
96	Protein digestion and absorption_Homo sapiens_hsa04974	0.23766635
97	Alcoholism_Homo sapiens_hsa05034	0.23572327
98	Salmonella infection_Homo sapiens_hsa05132	0.22927118
99	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.22215085
100	Shigellosis_Homo sapiens_hsa05131	0.21592100

ATP1B3P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »