ATP1B4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin filament-based movement (GO:0030048)9.65197494
2regulation of skeletal muscle contraction (GO:0014819)9.47437585
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.43060125
4plasma membrane repair (GO:0001778)7.68415699
5negative regulation of potassium ion transmembrane transport (GO:1901380)7.09488817
6striated muscle contraction (GO:0006941)6.81275657
7myofibril assembly (GO:0030239)5.85722618
8response to muscle activity (GO:0014850)5.66296097
9sarcomere organization (GO:0045214)5.37476003
10skeletal muscle fiber development (GO:0048741)5.19203306
11positive regulation of fatty acid beta-oxidation (GO:0032000)5.10724921
12myotube cell development (GO:0014904)5.09337890
13negative regulation of protein localization to cell surface (GO:2000009)4.97779853
14regulation of cell communication by electrical coupling (GO:0010649)4.95537674
15regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.83491026
16muscle contraction (GO:0006936)4.78961473
17regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.76818980
18skeletal muscle adaptation (GO:0043501)4.66062011
19muscle cell fate commitment (GO:0042693)4.47578821
20cardiac myofibril assembly (GO:0055003)4.40548713
21negative regulation of fatty acid transport (GO:2000192)4.33359336
22actomyosin structure organization (GO:0031032)4.20179456
23muscle system process (GO:0003012)4.15886136
24regulation of calcium ion transmembrane transporter activity (GO:1901019)4.15725203
25regulation of calcium ion transmembrane transport (GO:1903169)4.15725203
26negative regulation of calcium ion transmembrane transport (GO:1903170)4.12814425
27negative regulation of calcium ion transmembrane transporter activity (GO:1901020)4.12814425
28positive regulation of myoblast differentiation (GO:0045663)4.12537305
29skeletal muscle tissue regeneration (GO:0043403)4.12166332
30positive regulation of fatty acid oxidation (GO:0046321)4.06450320
31cytidine metabolic process (GO:0046087)4.01289658
32cytidine catabolic process (GO:0006216)4.01289658
33cytidine deamination (GO:0009972)4.01289658
34creatine metabolic process (GO:0006600)4.01032452
35insulin-like growth factor receptor signaling pathway (GO:0048009)3.98405919
36regulation of sarcomere organization (GO:0060297)3.97324987
37regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.92802379
38muscle fiber development (GO:0048747)3.81238779
39muscle organ development (GO:0007517)3.77759141
40muscle cell cellular homeostasis (GO:0046716)3.77191670
41regulation of actin filament-based movement (GO:1903115)3.76710101
42muscle structure development (GO:0061061)3.73140815
43cardiac muscle contraction (GO:0060048)3.63476592
44striated muscle adaptation (GO:0014888)3.63003791
45adult heart development (GO:0007512)3.59609456
46neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.58601587
47regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.58373564
48pyrimidine ribonucleoside catabolic process (GO:0046133)3.56095289
49response to caffeine (GO:0031000)3.54789008
50muscle tissue morphogenesis (GO:0060415)3.52900145
51positive regulation of protein depolymerization (GO:1901881)3.51854359
52muscle atrophy (GO:0014889)3.51686307
53muscle hypertrophy (GO:0014896)3.51319279
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50902937
55negative regulation of muscle hypertrophy (GO:0014741)3.49324753
56regulation of myoblast differentiation (GO:0045661)3.48161839
57striated muscle tissue development (GO:0014706)3.47255216
58positive regulation of glycogen biosynthetic process (GO:0045725)3.46812562
59negative regulation of ion transmembrane transporter activity (GO:0032413)3.44741968
60positive regulation of myotube differentiation (GO:0010831)3.44658001
61myoblast fusion (GO:0007520)3.41905151
62regulation of fatty acid beta-oxidation (GO:0031998)3.39699189
63regulation of membrane repolarization (GO:0060306)3.37758987
64positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.37309415
65carnitine shuttle (GO:0006853)3.37298617
66response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.37124150
67cellular response to dexamethasone stimulus (GO:0071549)3.35208805
68negative regulation of potassium ion transport (GO:0043267)3.34578271
69nucleus localization (GO:0051647)3.33926583
70ubiquinone biosynthetic process (GO:0006744)3.33537430
71myotube differentiation (GO:0014902)3.33108945
72regulation of potassium ion transmembrane transporter activity (GO:1901016)3.32581092
73negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.31304491
74cardiac muscle tissue morphogenesis (GO:0055008)3.30016169
75G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.29127939
76muscle cell development (GO:0055001)3.27285074
77regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.22156970
78positive regulation of insulin receptor signaling pathway (GO:0046628)3.21506567
79extracellular regulation of signal transduction (GO:1900115)3.20472206
80extracellular negative regulation of signal transduction (GO:1900116)3.20472206
81regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.20088356
82regulation of muscle system process (GO:0090257)3.19320441
83response to dexamethasone (GO:0071548)3.18150487
84glycogen biosynthetic process (GO:0005978)3.17677509
85glucan biosynthetic process (GO:0009250)3.17677509
86negative regulation of norepinephrine secretion (GO:0010700)3.16325143
87positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.16158034
88fatty acid transmembrane transport (GO:1902001)3.12654359
89negative regulation of cell size (GO:0045792)3.11994704
90regulation of the force of heart contraction (GO:0002026)3.11051355
91negative regulation of heart growth (GO:0061117)3.10701332
92negative regulation of cardiac muscle tissue growth (GO:0055022)3.10701332
93syncytium formation by plasma membrane fusion (GO:0000768)3.08266627
94extracellular fibril organization (GO:0043206)3.06897475
95regulation of fatty acid oxidation (GO:0046320)3.06684593
96cardiac muscle cell development (GO:0055013)3.06022718
97striated muscle cell development (GO:0055002)3.05928044
98regulation of p38MAPK cascade (GO:1900744)3.05862960
99positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.05459628
100glycogen catabolic process (GO:0005980)3.04437664
101regulation of muscle contraction (GO:0006937)3.02735530
102regulation of skeletal muscle cell differentiation (GO:2001014)3.02222304
103skeletal muscle tissue development (GO:0007519)3.01694036
104muscle tissue development (GO:0060537)3.01366317
105negative regulation of calcium ion transport (GO:0051926)3.01162358
106positive regulation of striated muscle cell differentiation (GO:0051155)2.99958993
107regulation of sequestering of triglyceride (GO:0010889)2.98227315
108ubiquinone metabolic process (GO:0006743)2.96312207
109regulation of skeletal muscle fiber development (GO:0048742)2.96187240
110positive regulation of glomerulus development (GO:0090193)2.95412247
111response to inactivity (GO:0014854)2.94691195
112regulation of ATP catabolic process (GO:1903289)2.93296087
113regulation of ATPase activity (GO:0043462)2.93296087
114positive regulation of glycogen metabolic process (GO:0070875)2.92704427
115striated muscle atrophy (GO:0014891)2.91616460
116regulation of muscle hypertrophy (GO:0014743)2.90661188
117behavioral response to nicotine (GO:0035095)2.89859974
118cardiac muscle hypertrophy (GO:0003300)2.89546303
119sequestering of extracellular ligand from receptor (GO:0035581)2.88874845
120neurotransmitter catabolic process (GO:0042135)2.87791969
121regulation of striated muscle contraction (GO:0006942)2.87314401
122cardiac cell development (GO:0055006)2.87089034
123positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.86617106
124regulation of cardiac muscle cell differentiation (GO:2000725)2.86572183
125syncytium formation (GO:0006949)2.85424615
126glucan catabolic process (GO:0009251)2.84101073
127muscle organ morphogenesis (GO:0048644)2.80104025
128striated muscle hypertrophy (GO:0014897)2.79734064
129positive regulation of cation channel activity (GO:2001259)2.78000981
130muscle adaptation (GO:0043500)2.77683243
131positive regulation of skeletal muscle tissue development (GO:0048643)2.77371115
132actin-myosin filament sliding (GO:0033275)15.2988299
133muscle filament sliding (GO:0030049)15.2988299
134skeletal muscle contraction (GO:0003009)12.7534708
135actin-mediated cell contraction (GO:0070252)12.6744293
136sarcoplasmic reticulum calcium ion transport (GO:0070296)10.6471913
137regulation of relaxation of muscle (GO:1901077)10.0709469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.96357304
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.85902484
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.23144368
4EZH2_22144423_ChIP-Seq_EOC_Human3.07185609
5GBX2_23144817_ChIP-Seq_PC3_Human3.04589074
6IGF1R_20145208_ChIP-Seq_DFB_Human2.57267934
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.56630182
8VDR_22108803_ChIP-Seq_LS180_Human2.44200836
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.40808696
10AR_21572438_ChIP-Seq_LNCaP_Human2.15282155
11DROSHA_22980978_ChIP-Seq_HELA_Human2.11952800
12ZNF274_21170338_ChIP-Seq_K562_Hela2.11492157
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04549562
14BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.99659293
15RBPJ_22232070_ChIP-Seq_NCS_Mouse1.99373993
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98176421
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.96974548
18EP300_21415370_ChIP-Seq_HL-1_Mouse1.92548320
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.81132005
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77073004
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77073004
22TBX20_22328084_ChIP-Seq_HEART_Mouse1.75407273
23TBX20_22080862_ChIP-Seq_HEART_Mouse1.75407273
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73062170
25* CBX2_27304074_Chip-Seq_ESCs_Mouse1.73039093
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70706480
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68644303
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58105016
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57604534
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55839516
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55081113
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50927763
33TAF15_26573619_Chip-Seq_HEK293_Human1.48399701
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.46870216
35CJUN_26792858_Chip-Seq_BT549_Human1.45940858
36EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.45896219
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.43953340
38CRX_20693478_ChIP-Seq_RETINA_Mouse1.42805983
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.42669521
40ER_23166858_ChIP-Seq_MCF-7_Human1.42033171
41CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41330044
42FUS_26573619_Chip-Seq_HEK293_Human1.39528091
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37344238
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36529605
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36051924
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35496484
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33094069
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32610202
49TP53_16413492_ChIP-PET_HCT116_Human1.30668751
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30256168
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30256168
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30145233
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28796101
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27452882
55P300_19829295_ChIP-Seq_ESCs_Human1.27345607
56NANOG_19829295_ChIP-Seq_ESCs_Human1.27048479
57SOX2_19829295_ChIP-Seq_ESCs_Human1.27048479
58TP53_18474530_ChIP-ChIP_U2OS_Human1.26478399
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26292553
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26264381
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.26142858
62SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.25887779
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.25763390
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.25655357
65CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24462923
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23465964
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.21853281
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21286986
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20674103
70OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20561534
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20164579
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20139027
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19946733
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18294059
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18174658
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17405475
77EGR1_19032775_ChIP-ChIP_M12_Human1.16913119
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15734814
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15497606
80TCF4_23295773_ChIP-Seq_U87_Human1.15300662
81EZH2_27304074_Chip-Seq_ESCs_Mouse1.14660169
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13907338
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13590871
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.13562904
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.12271624
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11823445
87SMAD4_21799915_ChIP-Seq_A2780_Human1.11311243
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10990275
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10533444
90AR_19668381_ChIP-Seq_PC3_Human1.10063754
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09235029
92CBP_20019798_ChIP-Seq_JUKART_Human1.09235029
93TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09003219
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.08140315
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07766529
96STAT3_23295773_ChIP-Seq_U87_Human1.07473425
97EED_16625203_ChIP-ChIP_MESCs_Mouse1.07021025
98P53_22387025_ChIP-Seq_ESCs_Mouse1.06941880
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.06507515
100BCAT_22108803_ChIP-Seq_LS180_Human1.06438271
101SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05985730
102ZNF263_19887448_ChIP-Seq_K562_Human1.05338532
103LXR_22158963_ChIP-Seq_LIVER_Mouse1.04909610
104SMAD3_21741376_ChIP-Seq_HESCs_Human1.04203261
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03561546
106RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03051928
107RNF2_27304074_Chip-Seq_ESCs_Mouse1.02167077
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02082465
109PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01983412
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01325783
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01044968
112VDR_24787735_ChIP-Seq_THP-1_Human0.99980692
113MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99918841
114MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99648037
115HTT_18923047_ChIP-ChIP_STHdh_Human0.99551506
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98955684
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98915620
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97159000
119JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96720142
120CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95985817
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95531167
122SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95309740
123TP53_22573176_ChIP-Seq_HFKS_Human0.95298563
124STAT3_18555785_Chip-Seq_ESCs_Mouse0.94426194
125TP63_17297297_ChIP-ChIP_HaCaT_Human0.93664040
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93162636
127AR_25329375_ChIP-Seq_VCAP_Human0.92943309
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92928641
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91935243
130SMAD4_21741376_ChIP-Seq_EPCs_Human0.90324068
131CLOCK_20551151_ChIP-Seq_293T_Human0.89861342
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89691130
133POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89170849
134AHR_22903824_ChIP-Seq_MCF-7_Human0.88727230
135ESR1_21235772_ChIP-Seq_MCF-7_Human0.88249948
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87342186
137JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87098772
138SMAD_19615063_ChIP-ChIP_OVARY_Human0.86780935
139TCF4_22108803_ChIP-Seq_LS180_Human0.86040142
140TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85929702
141NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85822673
142WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85257719
143POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84328605
144TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84328605
145SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83502829
146ARNT_22903824_ChIP-Seq_MCF-7_Human0.83182798
147KDM2B_26808549_Chip-Seq_REH_Human0.82634687
148FLI1_27457419_Chip-Seq_LIVER_Mouse0.81594384

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio6.51333387
2MP0000749_muscle_degeneration5.93168998
3MP0000751_myopathy5.51143727
4MP0008438_abnormal_cutaneous_collagen4.53596005
5MP0000747_muscle_weakness4.16387270
6MP0005275_abnormal_skin_tensile3.56452736
7MP0003950_abnormal_plasma_membrane3.48708300
8MP0002106_abnormal_muscle_physiology3.34042893
9MP0004087_abnormal_muscle_fiber3.32913890
10MP0002837_dystrophic_cardiac_calcinosis3.25520824
11MP0004272_abnormal_basement_membrane3.04086388
12MP0000759_abnormal_skeletal_muscle2.95759672
13MP0005369_muscle_phenotype2.86569702
14MP0005620_abnormal_muscle_contractility2.80751813
15MP0002269_muscular_atrophy2.79361708
16MP0004036_abnormal_muscle_relaxation2.73000673
17MP0000733_abnormal_muscle_development2.65903052
18MP0004484_altered_response_of2.63247080
19MP0004264_abnormal_extraembryonic_tissu2.53999573
20MP0004510_myositis2.53368404
21MP0000750_abnormal_muscle_regeneration2.49969765
22MP0005503_abnormal_tendon_morphology2.43404623
23MP0004130_abnormal_muscle_cell2.38632406
24MP0005330_cardiomyopathy2.36559671
25MP0002108_abnormal_muscle_morphology2.33957128
26MP0003122_maternal_imprinting2.08204455
27MP0003646_muscle_fatigue2.01672282
28MP0004084_abnormal_cardiac_muscle1.93852486
29MP0004215_abnormal_myocardial_fiber1.87334839
30MP0003045_fibrosis1.85301086
31MP0002972_abnormal_cardiac_muscle1.70529616
32MP0004233_abnormal_muscle_weight1.48027412
33MP0010630_abnormal_cardiac_muscle1.43751788
34MP0004270_analgesia1.42549550
35MP0008775_abnormal_heart_ventricle1.22264034
36MP0002332_abnormal_exercise_endurance1.21902448
37MP0003705_abnormal_hypodermis_morpholog1.21238391
38MP0006276_abnormal_autonomic_nervous1.19480547
39MP0002089_abnormal_postnatal_growth/wei1.19023152
40MP0009384_cardiac_valve_regurgitation1.12654162
41MP0002127_abnormal_cardiovascular_syste1.11583432
42MP0000372_irregular_coat_pigmentation1.09453154
43MP0004134_abnormal_chest_morphology1.09216167
44MP0004147_increased_porphyrin_level1.05978738
45MP0003123_paternal_imprinting1.03148815
46MP0001299_abnormal_eye_distance/1.01112273
47MP0002971_abnormal_brown_adipose0.98459047
48MP0003121_genomic_imprinting0.91139101
49MP0000013_abnormal_adipose_tissue0.87314453
50MP0005623_abnormal_meninges_morphology0.87023035
51MP0001958_emphysema0.81832921
52MP0002166_altered_tumor_susceptibility0.80651573
53MP0001661_extended_life_span0.80294093
54MP0002896_abnormal_bone_mineralization0.79531374
55MP0003137_abnormal_impulse_conducting0.77238778
56MP0005076_abnormal_cell_differentiation0.76395865
57MP0002876_abnormal_thyroid_physiology0.76188153
58MP0005645_abnormal_hypothalamus_physiol0.74813928
59MP0003279_aneurysm0.74180802
60MP0002102_abnormal_ear_morphology0.73700364
61MP0003136_yellow_coat_color0.73674694
62MP0002638_abnormal_pupillary_reflex0.73215006
63MP0005385_cardiovascular_system_phenoty0.72596160
64MP0001544_abnormal_cardiovascular_syste0.72596160
65MP0004197_abnormal_fetal_growth/weight/0.72406742
66MP0009250_abnormal_appendicular_skeleto0.70343469
67MP0003879_abnormal_hair_cell0.70042162
68MP0002168_other_aberrant_phenotype0.68992309
69MP0003941_abnormal_skin_development0.67375903
70MP0002734_abnormal_mechanical_nocicepti0.67245684
71MP0002006_tumorigenesis0.66529333
72MP0005334_abnormal_fat_pad0.66258180
73MP0002163_abnormal_gland_morphology0.65548756
74MP0000343_altered_response_to0.65391499
75MP0004185_abnormal_adipocyte_glucose0.64811963
76MP0005666_abnormal_adipose_tissue0.64384547
77MP0000767_abnormal_smooth_muscle0.64039355
78MP0002249_abnormal_larynx_morphology0.63331544
79MP0005166_decreased_susceptibility_to0.62195028
80MP0002060_abnormal_skin_morphology0.61306304
81MP0002234_abnormal_pharynx_morphology0.61282587
82MP0001986_abnormal_taste_sensitivity0.61067834
83MP0005451_abnormal_body_composition0.60853132
84MP0006292_abnormal_olfactory_placode0.60602921
85MP0004043_abnormal_pH_regulation0.58460074
86MP0003385_abnormal_body_wall0.57504671
87MP0008569_lethality_at_weaning0.56118410
88MP0000266_abnormal_heart_morphology0.55490710
89MP0010030_abnormal_orbit_morphology0.55441152
90MP0005595_abnormal_vascular_smooth0.54750831
91MP0003252_abnormal_bile_duct0.54314056
92MP0004885_abnormal_endolymph0.53342664
93MP0005375_adipose_tissue_phenotype0.52873503
94MP0002138_abnormal_hepatobiliary_system0.52773436
95MP0005551_abnormal_eye_electrophysiolog0.52028358
96MP0006036_abnormal_mitochondrial_physio0.51078651
97MP0002114_abnormal_axial_skeleton0.49707807
98MP0003567_abnormal_fetal_cardiomyocyte0.48968938
99MP0000462_abnormal_digestive_system0.48461102
100MP0005171_absent_coat_pigmentation0.47910932
101MP0009115_abnormal_fat_cell0.47773493
102MP0009780_abnormal_chondrocyte_physiolo0.47073738
103MP0004142_abnormal_muscle_tone0.46717289
104MP0001485_abnormal_pinna_reflex0.45862146
105MP0004883_abnormal_blood_vessel0.45741553
106MP0005508_abnormal_skeleton_morphology0.44863098
107MP0000003_abnormal_adipose_tissue0.44701797
108MP0010368_abnormal_lymphatic_system0.44565570
109MP0002822_catalepsy0.44435302
110MP0003787_abnormal_imprinting0.44215234
111MP0002067_abnormal_sensory_capabilities0.43087124
112MP0003221_abnormal_cardiomyocyte_apopto0.42883778
113MP0001984_abnormal_olfaction0.42861810
114MP0004085_abnormal_heartbeat0.42492595
115MP0005670_abnormal_white_adipose0.41997836
116MP0001486_abnormal_startle_reflex0.41394824
117MP0003195_calcinosis0.41374676
118MP0006072_abnormal_retinal_apoptosis0.40845418
119MP0005423_abnormal_somatic_nervous0.40522239
120MP0002128_abnormal_blood_circulation0.40364267
121MP0003283_abnormal_digestive_organ0.39838106
122MP0005253_abnormal_eye_physiology0.38972482
123MP0005167_abnormal_blood-brain_barrier0.38145486
124MP0002078_abnormal_glucose_homeostasis0.36158793
125MP0001529_abnormal_vocalization0.35879612
126MP0005646_abnormal_pituitary_gland0.35874452
127MP0006138_congestive_heart_failure0.35704249
128MP0008961_abnormal_basal_metabolism0.35275747
129MP0002272_abnormal_nervous_system0.35185039
130MP0003638_abnormal_response/metabolism_0.35178572
131MP0003948_abnormal_gas_homeostasis0.35115815
132MP0005452_abnormal_adipose_tissue0.34707873
133MP0005379_endocrine/exocrine_gland_phen0.34430089
134MP0002184_abnormal_innervation0.33991504
135MP0005083_abnormal_biliary_tract0.33987038
136MP0000534_abnormal_ureter_morphology0.33689435
137MP0005266_abnormal_metabolism0.33574835
138MP0000230_abnormal_systemic_arterial0.32455691
139MP0003566_abnormal_cell_adhesion0.32428421
140MP0008770_decreased_survivor_rate0.29541453

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.74980428
2Neoplasm of the heart (HP:0100544)6.49973792
3Round ear (HP:0100830)6.44268708
4Myopathic facies (HP:0002058)6.32919456
5Slender build (HP:0001533)5.98128396
6Ulnar deviation of the wrist (HP:0003049)5.69954755
7Trismus (HP:0000211)5.30022150
8Calcaneovalgus deformity (HP:0001848)5.25405790
9Exercise-induced myalgia (HP:0003738)5.14926759
10Muscle fiber splitting (HP:0003555)5.10191715
11Calf muscle hypertrophy (HP:0008981)4.93404648
12Muscle hypertrophy of the lower extremities (HP:0008968)4.78459254
13Deformed tarsal bones (HP:0008119)4.66156670
14Neck muscle weakness (HP:0000467)4.64553436
15Frequent falls (HP:0002359)4.60548083
16Metatarsus adductus (HP:0001840)4.57232300
17EMG: myopathic abnormalities (HP:0003458)4.56983478
18Absent phalangeal crease (HP:0006109)4.33171135
19Exercise-induced muscle cramps (HP:0003710)4.32026652
20Mildly elevated creatine phosphokinase (HP:0008180)4.26822762
21Symphalangism affecting the phalanges of the hand (HP:0009773)4.02517774
22Abnormality of the calf musculature (HP:0001430)4.01550679
23Spinal rigidity (HP:0003306)3.93833374
24Increased connective tissue (HP:0009025)3.85145586
25Abnormal finger flexion creases (HP:0006143)3.62340160
26Rimmed vacuoles (HP:0003805)3.58379905
27Hyporeflexia of lower limbs (HP:0002600)3.43894299
28Abnormality of skeletal muscle fiber size (HP:0012084)3.43474938
29Popliteal pterygium (HP:0009756)3.42448056
30Sudden death (HP:0001699)3.34112075
31Centrally nucleated skeletal muscle fibers (HP:0003687)3.26555740
32Abnormality of the calcaneus (HP:0008364)3.24198109
33Increased variability in muscle fiber diameter (HP:0003557)3.03416555
34EMG: neuropathic changes (HP:0003445)2.93079197
35Generalized muscle weakness (HP:0003324)2.75784900
36Fatigable weakness (HP:0003473)2.68518942
37Abnormality of the neuromuscular junction (HP:0003398)2.68518942
38Bulbar palsy (HP:0001283)2.64841890
39Ulnar deviation of finger (HP:0009465)2.59865103
40Abnormality of the left ventricular outflow tract (HP:0011103)2.56423579
41Subaortic stenosis (HP:0001682)2.56423579
42Bundle branch block (HP:0011710)2.56168614
43Deep philtrum (HP:0002002)2.55959101
44Difficulty running (HP:0009046)2.55638083
45Type 2 muscle fiber atrophy (HP:0003554)2.52836307
46Muscle stiffness (HP:0003552)2.46550394
47Cutaneous syndactyly (HP:0012725)2.42734456
48Hip contracture (HP:0003273)2.42515515
49Amniotic constriction ring (HP:0009775)2.39638069
50Abnormality of placental membranes (HP:0011409)2.39638069
51Hammertoe (HP:0001765)2.38102520
52Aplasia of the musculature (HP:0100854)2.36696148
53Ventricular tachycardia (HP:0004756)2.36454783
54Myotonia (HP:0002486)2.32343527
55Asymmetric septal hypertrophy (HP:0001670)2.25568686
56Hyperkalemia (HP:0002153)2.20579519
57Myoglobinuria (HP:0002913)2.15944277
58Muscle fiber atrophy (HP:0100295)2.12038880
59Waddling gait (HP:0002515)2.11395695
60Scapular winging (HP:0003691)2.11310166
61Gowers sign (HP:0003391)2.00608880
62Distal arthrogryposis (HP:0005684)14.4395444
63Nemaline bodies (HP:0003798)10.2435012
64Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)10.0772062
65Type 1 muscle fiber predominance (HP:0003803)10.0230209
66Adducted thumb (HP:0001181)1.97749055
67Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.96894048
68Distal lower limb muscle weakness (HP:0009053)1.93581592
69Fetal akinesia sequence (HP:0001989)1.91404112
70Limb-girdle muscle atrophy (HP:0003797)1.86853621
71Breech presentation (HP:0001623)1.83602136
72Rhabdomyolysis (HP:0003201)1.81244590
73Respiratory insufficiency due to muscle weakness (HP:0002747)1.79857477
74Muscular dystrophy (HP:0003560)1.78359764
75Limited hip movement (HP:0008800)1.74883679
76Facial diplegia (HP:0001349)1.74032550
77Akinesia (HP:0002304)1.73649083
78Malignant hyperthermia (HP:0002047)1.71270581
79Nonprogressive disorder (HP:0003680)1.69681742
80Diaphragmatic weakness (HP:0009113)1.66615605
81Heart block (HP:0012722)1.64016566
82Tarsal synostosis (HP:0008368)1.62447396
83Aplasia/Hypoplasia involving the musculature (HP:0001460)1.60493234
84Type II lissencephaly (HP:0007260)1.59034647
85Rocker bottom foot (HP:0001838)1.56417336
86Hypoplastic ischia (HP:0003175)1.55794544
87Areflexia of lower limbs (HP:0002522)1.55485337
88Abnormality of the shoulder girdle musculature (HP:0001435)1.55319284
89Atrial fibrillation (HP:0005110)1.55312121
90Broad metatarsal (HP:0001783)1.54634769
91Proximal amyotrophy (HP:0007126)1.52545085
92Left ventricular hypertrophy (HP:0001712)1.52082731
93Foot dorsiflexor weakness (HP:0009027)1.51954541
94Limb-girdle muscle weakness (HP:0003325)1.51939794
95Difficulty climbing stairs (HP:0003551)1.51581099
96Ankle contracture (HP:0006466)1.51462996
97Steppage gait (HP:0003376)1.51217225
98Cerebral aneurysm (HP:0004944)1.48583312
99Synostosis involving bones of the feet (HP:0009140)1.47350055
100Synostosis involving bones of the lower limbs (HP:0009138)1.47350055
101Abnormal atrioventricular conduction (HP:0005150)1.47146495
102Distal lower limb amyotrophy (HP:0008944)1.47117365
103Webbed neck (HP:0000465)1.46056024
104Lipoatrophy (HP:0100578)1.44394632
105Cerebellar dysplasia (HP:0007033)1.43965686
106Abnormality of the foot musculature (HP:0001436)1.43745884
107Protrusio acetabuli (HP:0003179)1.43605229
108Primary atrial arrhythmia (HP:0001692)1.42930416
109Abnormality of the ischium (HP:0003174)1.41874229
110Pelvic girdle muscle weakness (HP:0003749)1.40501400
111Mitral valve prolapse (HP:0001634)1.39617892
112Striae distensae (HP:0001065)1.38870093
113Shoulder girdle muscle weakness (HP:0003547)1.36531817
114Abnormality of the hip-girdle musculature (HP:0001445)1.34899445
115Abnormality of the musculature of the pelvis (HP:0001469)1.34899445
116Weak cry (HP:0001612)1.33642483
117Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.33563071
118Lower limb amyotrophy (HP:0007210)1.32390396
119Dilated cardiomyopathy (HP:0001644)1.32019766
120Achilles tendon contracture (HP:0001771)1.30238805
121Congenital hip dislocation (HP:0001374)1.26667839
122Progressive muscle weakness (HP:0003323)1.26406484
123Long clavicles (HP:0000890)1.24117928
124Abnormality of the Achilles tendon (HP:0005109)1.21428192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG4.96539458
2SIK14.05952504
3TTN2.84509650
4PHKG12.25478712
5PHKG22.25478712
6DMPK2.17060967
7OBSCN13.2081170
8MUSK1.91289507
9NME11.80547559
10FRK1.77581917
11PIK3CA1.38762407
12CCNB11.36625284
13MARK11.29178305
14MAP4K21.28793766
15INSRR1.22704263
16CSF1R1.22328904
17ADRBK21.18324019
18MAP3K71.15383362
19EIF2AK21.14015198
20BMPR1B1.13967493
21ZAK1.06754008
22TRIB30.98635460
23RIPK10.98442529
24JAK10.96404862
25EPHB10.95583038
26MOS0.93557668
27MAPK120.91298062
28ERBB30.90036195
29MAP2K60.84219255
30NEK10.83402439
31WNK40.75990820
32ROCK10.75585896
33PKN20.75150522
34PDGFRA0.74867084
35PDK30.73639055
36PDK40.73639055
37MAPK70.70130808
38MAPKAPK30.69529463
39ROCK20.69185507
40BCKDK0.68981663
41MARK30.66570275
42STK110.65556847
43TGFBR20.64667527
44TNIK0.64303126
45TIE10.63873633
46PTK60.61358676
47NUAK10.57642675
48MAP2K30.57513374
49FGFR40.57357585
50WNK30.56993692
51TRPM70.55037921
52MAP2K10.54767571
53CAMK10.53445923
54OXSR10.50826839
55PRKAA10.48960682
56CAMK2D0.48948075
57GRK70.48858277
58NLK0.48248154
59CAMK40.48118174
60DYRK1B0.46588950
61NEK90.46466932
62MAP2K40.46150097
63PKN10.44576818
64PRKG10.43633423
65TLK10.43566692
66PRKCQ0.43150066
67PINK10.42423292
68MAP3K40.42290778
69DDR20.41938072
70TAOK30.41806446
71PRKAA20.41419141
72TXK0.40797303
73LIMK10.39401161
74STK390.39047693
75SGK10.38517283
76AKT20.38270682
77CAMK2G0.36334330
78TYK20.36241936
79NTRK30.36154840
80LATS10.36034830
81STK38L0.34724312
82PRKCH0.34388993
83TGFBR10.34304452
84MAPKAPK50.34207241
85RPS6KB10.33389632
86CASK0.32928347
87RET0.32553767
88PDK20.32271434
89GRK10.31957318
90MTOR0.30940169
91KIT0.30914695
92CAMK1G0.30878766
93MAPK110.29844853
94CSNK1G10.29841177
95PDPK10.28454503
96PDK10.28346505
97MAP2K20.27828869
98ADRBK10.27055184
99EEF2K0.26793027
100FGFR30.26767914
101IKBKB0.26674094
102CAMK1D0.26243122
103CHUK0.26137457
104PDGFRB0.25412268
105CSNK1G20.25262156
106RPS6KB20.24817208
107MAPK130.24707459
108MAP3K100.24209991
109CDK190.23715986
110CAMK2A0.23492853
111PRKD10.22900537
112CAMK2B0.22819850
113EPHA30.22538424
114STK160.22126616
115MAP3K130.21243109
116PRKACB0.20810862
117NTRK20.20802334
118TNK20.19880235
119ILK0.19520099
120PRKCE0.19235368
121SGK30.18401214
122PRKACA0.17963694
123PRKCA0.17507349
124CSNK1D0.16699487
125RPS6KA30.16133491
126FGFR20.15661152
127RPS6KA60.15099464
128SGK20.15087461
129CSNK1G30.14600615
130INSR0.14564375
131DAPK20.14478218
132PAK60.13618430
133ACVR1B0.13427334
134WNK10.13203524
135MST1R0.12489954
136HCK0.12381552
137IGF1R0.12043886
138RPS6KA10.11640973
139MARK20.11393399
140MAPK40.11326082
141PTK2B0.10675506
142PRKACG0.10671563
143SIK20.10243956
144MAP3K90.10079405
145SGK4940.09919639
146SGK2230.09919639
147FYN0.09833514

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.31538356
2Dilated cardiomyopathy_Homo sapiens_hsa054144.31287375
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.55054516
4ECM-receptor interaction_Homo sapiens_hsa045122.42203918
5Tight junction_Homo sapiens_hsa045302.37098544
6Phototransduction_Homo sapiens_hsa047442.34746818
7Circadian rhythm_Homo sapiens_hsa047102.31924434
8* Cardiac muscle contraction_Homo sapiens_hsa042602.30664575
9Viral myocarditis_Homo sapiens_hsa054162.23993947
10Focal adhesion_Homo sapiens_hsa045102.21340825
11* Protein digestion and absorption_Homo sapiens_hsa049741.86779985
12Fatty acid degradation_Homo sapiens_hsa000711.82332588
13Oxytocin signaling pathway_Homo sapiens_hsa049211.80131635
14* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78808451
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77500186
16Parkinsons disease_Homo sapiens_hsa050121.77183168
17Renin-angiotensin system_Homo sapiens_hsa046141.73498276
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.73144592
19Insulin resistance_Homo sapiens_hsa049311.72501865
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72302288
21Starch and sucrose metabolism_Homo sapiens_hsa005001.68414084
22Oxidative phosphorylation_Homo sapiens_hsa001901.67036121
23Linoleic acid metabolism_Homo sapiens_hsa005911.64427132
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.64308401
25Alzheimers disease_Homo sapiens_hsa050101.62633742
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.57545002
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.55403211
28Insulin signaling pathway_Homo sapiens_hsa049101.52492280
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.47785900
30Propanoate metabolism_Homo sapiens_hsa006401.47486159
31Amoebiasis_Homo sapiens_hsa051461.42376779
32Glucagon signaling pathway_Homo sapiens_hsa049221.41851032
33Nitrogen metabolism_Homo sapiens_hsa009101.41227269
34Type II diabetes mellitus_Homo sapiens_hsa049301.32214884
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31263803
36Calcium signaling pathway_Homo sapiens_hsa040201.29963735
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25489896
38AMPK signaling pathway_Homo sapiens_hsa041521.16550020
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11752914
40Fatty acid metabolism_Homo sapiens_hsa012121.11204985
41* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10251039
42Proteoglycans in cancer_Homo sapiens_hsa052051.09662620
43* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09122050
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.08832450
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01768644
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99412863
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98980009
48Renin secretion_Homo sapiens_hsa049240.98844808
49PPAR signaling pathway_Homo sapiens_hsa033200.98056699
50Platelet activation_Homo sapiens_hsa046110.97819713
51Carbon metabolism_Homo sapiens_hsa012000.94734675
52* Gastric acid secretion_Homo sapiens_hsa049710.91283760
53Regulation of autophagy_Homo sapiens_hsa041400.89061256
54mTOR signaling pathway_Homo sapiens_hsa041500.87755409
55Adherens junction_Homo sapiens_hsa045200.87201493
56Circadian entrainment_Homo sapiens_hsa047130.84646228
57Pyruvate metabolism_Homo sapiens_hsa006200.83578745
58Huntingtons disease_Homo sapiens_hsa050160.83244363
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81609556
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81509065
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.80965546
62GnRH signaling pathway_Homo sapiens_hsa049120.80805668
63Peroxisome_Homo sapiens_hsa041460.79714982
64Butanoate metabolism_Homo sapiens_hsa006500.78661053
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78277448
66Arginine biosynthesis_Homo sapiens_hsa002200.71611045
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68121619
68FoxO signaling pathway_Homo sapiens_hsa040680.67009629
69* Insulin secretion_Homo sapiens_hsa049110.66351682
70Ovarian steroidogenesis_Homo sapiens_hsa049130.66319702
71Cholinergic synapse_Homo sapiens_hsa047250.64972149
72Amphetamine addiction_Homo sapiens_hsa050310.64248039
73Olfactory transduction_Homo sapiens_hsa047400.63954415
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63828100
75Biosynthesis of amino acids_Homo sapiens_hsa012300.63252895
76Fatty acid elongation_Homo sapiens_hsa000620.62719168
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62378343
78Ether lipid metabolism_Homo sapiens_hsa005650.62348621
79ABC transporters_Homo sapiens_hsa020100.62085481
80MAPK signaling pathway_Homo sapiens_hsa040100.61813641
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61372502
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58122461
83* Bile secretion_Homo sapiens_hsa049760.56985728
84* Salivary secretion_Homo sapiens_hsa049700.55385361
85Long-term depression_Homo sapiens_hsa047300.55235618
86HIF-1 signaling pathway_Homo sapiens_hsa040660.55076676
87Arginine and proline metabolism_Homo sapiens_hsa003300.54867713
88Prion diseases_Homo sapiens_hsa050200.53427930
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53105423
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53051664
91Lysine degradation_Homo sapiens_hsa003100.52944204
92GABAergic synapse_Homo sapiens_hsa047270.51963271
93Glioma_Homo sapiens_hsa052140.51528766
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51139549
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49745518
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49639550
97Staphylococcus aureus infection_Homo sapiens_hsa051500.49537217
98MicroRNAs in cancer_Homo sapiens_hsa052060.49085889
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.48695989
100Tryptophan metabolism_Homo sapiens_hsa003800.48404184
101Dopaminergic synapse_Homo sapiens_hsa047280.47547809
102Fatty acid biosynthesis_Homo sapiens_hsa000610.47521913
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46508878
104beta-Alanine metabolism_Homo sapiens_hsa004100.46203040
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.44441956
106Taste transduction_Homo sapiens_hsa047420.44343756
107Dorso-ventral axis formation_Homo sapiens_hsa043200.44058834
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43314641
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.43193139
110Selenocompound metabolism_Homo sapiens_hsa004500.42962003
111Serotonergic synapse_Homo sapiens_hsa047260.42719635
112RNA degradation_Homo sapiens_hsa030180.42276759
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41961230
114Gap junction_Homo sapiens_hsa045400.40931861
115Caffeine metabolism_Homo sapiens_hsa002320.37428548
116Sulfur metabolism_Homo sapiens_hsa009200.37193827
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36314719
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.36207219
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35889638
120Purine metabolism_Homo sapiens_hsa002300.35090899
121Small cell lung cancer_Homo sapiens_hsa052220.34561247
122Morphine addiction_Homo sapiens_hsa050320.34099744
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.33954873
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33555426
125Melanogenesis_Homo sapiens_hsa049160.33182737
126* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33093036
127Complement and coagulation cascades_Homo sapiens_hsa046100.33047157
128Malaria_Homo sapiens_hsa051440.32955930
129Toxoplasmosis_Homo sapiens_hsa051450.32799741
130Axon guidance_Homo sapiens_hsa043600.32545599
131Fructose and mannose metabolism_Homo sapiens_hsa000510.32189437
132* cAMP signaling pathway_Homo sapiens_hsa040240.31899125
133Sulfur relay system_Homo sapiens_hsa041220.31369575
134VEGF signaling pathway_Homo sapiens_hsa043700.30467623
135Basal transcription factors_Homo sapiens_hsa030220.30228084
136Long-term potentiation_Homo sapiens_hsa047200.29807241
137Estrogen signaling pathway_Homo sapiens_hsa049150.29669483
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.27024608
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25975697
140Arachidonic acid metabolism_Homo sapiens_hsa005900.25703038

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