ATP23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.01689934
2proteasome assembly (GO:0043248)4.87400943
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.24253129
4oxidative phosphorylation (GO:0006119)4.06799409
5pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.06777317
6CENP-A containing nucleosome assembly (GO:0034080)3.99648790
7telomere maintenance via semi-conservative replication (GO:0032201)3.92691476
8chromatin remodeling at centromere (GO:0031055)3.87565531
9pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.83472054
10ribosomal small subunit assembly (GO:0000028)3.82228083
11DNA strand elongation involved in DNA replication (GO:0006271)3.79370534
12ATP synthesis coupled proton transport (GO:0015986)3.76416049
13energy coupled proton transport, down electrochemical gradient (GO:0015985)3.76416049
14chaperone-mediated protein transport (GO:0072321)3.76309845
15deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.71003663
16deoxyribose phosphate biosynthetic process (GO:0046385)3.68929545
172-deoxyribonucleotide biosynthetic process (GO:0009265)3.68929545
18establishment of integrated proviral latency (GO:0075713)3.66785639
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.63709205
20formation of translation preinitiation complex (GO:0001731)3.63611847
21DNA strand elongation (GO:0022616)3.62832438
22regulation of mitochondrial translation (GO:0070129)3.58241756
23ribosomal large subunit biogenesis (GO:0042273)3.53539543
24DNA ligation (GO:0006266)3.52220323
25purine nucleotide salvage (GO:0032261)3.52014718
26purine nucleobase biosynthetic process (GO:0009113)3.48585710
27cullin deneddylation (GO:0010388)3.45336637
28pyrimidine nucleotide catabolic process (GO:0006244)3.44122777
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.42949676
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.42949676
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.42810040
32telomere maintenance via recombination (GO:0000722)3.42393384
33deoxyribonucleotide biosynthetic process (GO:0009263)3.39367931
34respiratory electron transport chain (GO:0022904)3.38953700
35protein targeting to mitochondrion (GO:0006626)3.37074659
36protein deneddylation (GO:0000338)3.36632120
37mitochondrial respiratory chain complex I assembly (GO:0032981)3.31838288
38NADH dehydrogenase complex assembly (GO:0010257)3.31838288
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31838288
40kinetochore organization (GO:0051383)3.31364738
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30678506
42DNA replication checkpoint (GO:0000076)3.30316124
43electron transport chain (GO:0022900)3.28905889
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.26541755
45rRNA modification (GO:0000154)3.25175290
46mitotic recombination (GO:0006312)3.24915903
47SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.24799412
48mitochondrial respiratory chain complex assembly (GO:0033108)3.24280660
49viral transcription (GO:0019083)3.23405387
50transcription from mitochondrial promoter (GO:0006390)3.20840934
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.19148645
52translation (GO:0006412)3.17881997
53cotranslational protein targeting to membrane (GO:0006613)3.17739539
54deoxyribose phosphate catabolic process (GO:0046386)3.16607626
55pseudouridine synthesis (GO:0001522)3.14919061
56aerobic respiration (GO:0009060)3.14693370
57translational termination (GO:0006415)3.13753069
58DNA replication-independent nucleosome organization (GO:0034724)3.13583870
59DNA replication-independent nucleosome assembly (GO:0006336)3.13583870
60protein complex biogenesis (GO:0070271)3.13350555
61protein targeting to ER (GO:0045047)3.13072987
62establishment of protein localization to mitochondrial membrane (GO:0090151)3.10175629
63nucleobase biosynthetic process (GO:0046112)3.09352141
64ribonucleoprotein complex biogenesis (GO:0022613)3.09177219
65histone exchange (GO:0043486)3.08751639
66kinetochore assembly (GO:0051382)3.08603135
67negative regulation of ligase activity (GO:0051352)3.07726183
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.07726183
69respiratory chain complex IV assembly (GO:0008535)3.07700378
70translational elongation (GO:0006414)3.07588648
71ribosomal small subunit biogenesis (GO:0042274)3.07263555
72deoxyribonucleotide catabolic process (GO:0009264)3.06239812
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.05209775
74heme biosynthetic process (GO:0006783)3.02205635
75ribosome biogenesis (GO:0042254)3.01682818
76establishment of protein localization to mitochondrion (GO:0072655)3.00974516
77establishment of protein localization to endoplasmic reticulum (GO:0072599)2.99921961
78exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99694050
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99354461
80protein localization to endoplasmic reticulum (GO:0070972)2.99236337
81protein localization to mitochondrion (GO:0070585)2.94725331
82cellular component biogenesis (GO:0044085)2.93493552
83translational initiation (GO:0006413)2.93414428
84positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.92612258
85regulation of cellular amino acid metabolic process (GO:0006521)2.90004085
86deoxyribose phosphate metabolic process (GO:0019692)2.89285722
87protein K6-linked ubiquitination (GO:0085020)2.88092462
88telomere maintenance via telomere lengthening (GO:0010833)2.86696106
892-deoxyribonucleotide metabolic process (GO:0009394)2.84465243
90DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.83938977
91DNA replication initiation (GO:0006270)2.83441106
92positive regulation of ligase activity (GO:0051351)2.82139956
93mitochondrial RNA metabolic process (GO:0000959)2.80822199
94signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.80780661
95intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.80780661
96iron-sulfur cluster assembly (GO:0016226)2.79096038
97metallo-sulfur cluster assembly (GO:0031163)2.79096038
98cytochrome complex assembly (GO:0017004)2.78860916
99purine-containing compound salvage (GO:0043101)2.78633623
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.78530826

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.67604755
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.56484674
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.87501393
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.70244564
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43688127
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.42913333
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.36401063
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.27926025
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05090511
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.95057684
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.93155181
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.82797619
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80228563
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76604017
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63435817
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63036442
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58370373
18VDR_23849224_ChIP-Seq_CD4+_Human2.54014491
19FOXP3_21729870_ChIP-Seq_TREG_Human2.52475516
20DCP1A_22483619_ChIP-Seq_HELA_Human2.46592384
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.46029420
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.43645241
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.31131173
24ELK1_19687146_ChIP-ChIP_HELA_Human2.30754893
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30332739
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29622455
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24183523
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23409305
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.19360884
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17931354
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.15406423
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13962102
33GABP_19822575_ChIP-Seq_HepG2_Human2.06738993
34FOXM1_23109430_ChIP-Seq_U2OS_Human2.06417521
35HOXB4_20404135_ChIP-ChIP_EML_Mouse2.04040035
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98570116
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91375015
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.88216889
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.87320873
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78268054
41XRN2_22483619_ChIP-Seq_HELA_Human1.78177628
42TTF2_22483619_ChIP-Seq_HELA_Human1.76357859
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65794181
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63891581
45AR_21909140_ChIP-Seq_LNCAP_Human1.60122142
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.59080207
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58573731
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56879870
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55427051
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52156417
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52041212
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46215769
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39825037
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35797019
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35053838
56MYC_18940864_ChIP-ChIP_HL60_Human1.34616925
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.32991050
58KDM5A_27292631_Chip-Seq_BREAST_Human1.32593017
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32574207
60TFEB_21752829_ChIP-Seq_HELA_Human1.31951824
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29838983
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28067092
63CIITA_25753668_ChIP-Seq_RAJI_Human1.26666453
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23804180
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16979579
66GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13667459
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13356206
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13229105
69SPI1_23547873_ChIP-Seq_NB4_Human1.11982952
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11013772
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06589308
72CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04951920
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99541277
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98203208
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97558852
76NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95702418
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94644623
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93482404
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91150658
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90745382
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89684117
82ZNF263_19887448_ChIP-Seq_K562_Human0.86859094
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86807581
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85533434
85PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.82797574
86FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80013452
87KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77183163
88MYB_26560356_Chip-Seq_TH2_Human0.76899545
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76015045
90TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74418640
91ELK1_22589737_ChIP-Seq_MCF10A_Human0.71388083
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.70309021
93SOX17_20123909_ChIP-Seq_XEN_Mouse0.69765189
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.67742268
95GATA2_22383799_ChIP-Seq_G1ME_Mouse0.67731499
96GATA1_22025678_ChIP-Seq_K562_Human0.67352420
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.67251589
98STAT3_1855785_ChIP-Seq_MESCs_Mouse0.65972777
99ELF5_23300383_ChIP-Seq_T47D_Human0.64331868
100IRF1_19129219_ChIP-ChIP_H3396_Human0.63786233

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.67505975
2MP0010094_abnormal_chromosome_stability4.04527374
3MP0008058_abnormal_DNA_repair3.88592927
4MP0003693_abnormal_embryo_hatching3.57952725
5MP0004957_abnormal_blastocyst_morpholog3.48360382
6MP0008007_abnormal_cellular_replicative3.30835271
7MP0006036_abnormal_mitochondrial_physio3.08223491
8MP0003786_premature_aging3.04159482
9MP0003111_abnormal_nucleus_morphology2.98190251
10MP0003077_abnormal_cell_cycle2.84996325
11MP0000372_irregular_coat_pigmentation2.81997700
12MP0003186_abnormal_redox_activity2.76615536
13MP0004147_increased_porphyrin_level2.62421921
14MP0009697_abnormal_copulation2.57319585
15MP0005075_abnormal_melanosome_morpholog2.52484529
16MP0008932_abnormal_embryonic_tissue2.38425552
17MP0006035_abnormal_mitochondrial_morpho2.32571271
18MP0008995_early_reproductive_senescence2.08144737
19MP0008057_abnormal_DNA_replication1.88001542
20MP0003718_maternal_effect1.86974361
21MP0002396_abnormal_hematopoietic_system1.78744603
22MP0000015_abnormal_ear_pigmentation1.74535252
23MP0008877_abnormal_DNA_methylation1.67046859
24MP0000358_abnormal_cell_content/1.63269552
25MP0003656_abnormal_erythrocyte_physiolo1.60718746
26MP0001764_abnormal_homeostasis1.58983717
27MP0002132_abnormal_respiratory_system1.45984467
28MP0003646_muscle_fatigue1.45166005
29MP0002160_abnormal_reproductive_system1.41336372
30MP0002095_abnormal_skin_pigmentation1.39053960
31MP0002019_abnormal_tumor_incidence1.34964260
32MP0005451_abnormal_body_composition1.32270952
33MP0004808_abnormal_hematopoietic_stem1.31997996
34MP0000350_abnormal_cell_proliferation1.31964283
35MP0000313_abnormal_cell_death1.31858801
36MP0002163_abnormal_gland_morphology1.30266232
37MP0006292_abnormal_olfactory_placode1.29284983
38MP0002877_abnormal_melanocyte_morpholog1.29136741
39MP0001730_embryonic_growth_arrest1.29006100
40MP0001929_abnormal_gametogenesis1.27356343
41MP0005379_endocrine/exocrine_gland_phen1.24213528
42MP0002210_abnormal_sex_determination1.23113763
43MP0001661_extended_life_span1.22329855
44MP0005408_hypopigmentation1.20183361
45MP0001697_abnormal_embryo_size1.17930278
46MP0003315_abnormal_perineum_morphology1.16521722
47MP0000689_abnormal_spleen_morphology1.12836426
48MP0001145_abnormal_male_reproductive1.12400143
49MP0005330_cardiomyopathy1.11221789
50MP0005083_abnormal_biliary_tract1.10792457
51MP0002398_abnormal_bone_marrow1.10054080
52MP0005389_reproductive_system_phenotype1.09326269
53MP0010307_abnormal_tumor_latency1.08939651
54MP0005464_abnormal_platelet_physiology1.06680554
55MP0002722_abnormal_immune_system1.04513739
56MP0000703_abnormal_thymus_morphology1.03038364
57MP0000653_abnormal_sex_gland1.02907627
58MP0004185_abnormal_adipocyte_glucose1.00405085
59MP0001853_heart_inflammation0.97262930
60MP0001835_abnormal_antigen_presentation0.96645195
61MP0009333_abnormal_splenocyte_physiolog0.95706223
62MP0002080_prenatal_lethality0.91111382
63MP0005266_abnormal_metabolism0.90803011
64MP0005636_abnormal_mineral_homeostasis0.88084220
65MP0004145_abnormal_muscle_electrophysio0.87713834
66MP0002429_abnormal_blood_cell0.87512714
67MP0000490_abnormal_crypts_of0.87338418
68MP0005645_abnormal_hypothalamus_physiol0.86732563
69MP0005332_abnormal_amino_acid0.86675771
70MP0003763_abnormal_thymus_physiology0.84856142
71MP0005174_abnormal_tail_pigmentation0.83708673
72MP0001529_abnormal_vocalization0.83336023
73MP0002938_white_spotting0.82801211
74MP0001881_abnormal_mammary_gland0.82718762
75MP0002148_abnormal_hypersensitivity_rea0.81862219
76MP0000678_abnormal_parathyroid_gland0.81154419
77MP0005084_abnormal_gallbladder_morpholo0.80220751
78MP0005220_abnormal_exocrine_pancreas0.80140007
79MP0003698_abnormal_male_reproductive0.78860089
80MP0005380_embryogenesis_phenotype0.78673927
81MP0001672_abnormal_embryogenesis/_devel0.78673927
82MP0006072_abnormal_retinal_apoptosis0.75754658
83MP0000716_abnormal_immune_system0.72692754
84MP0001119_abnormal_female_reproductive0.70329713
85MP0001800_abnormal_humoral_immune0.70294398
86MP0005584_abnormal_enzyme/coenzyme_acti0.69225727
87MP0005397_hematopoietic_system_phenotyp0.69008345
88MP0001545_abnormal_hematopoietic_system0.69008345
89MP0003984_embryonic_growth_retardation0.68529343
90MP0005671_abnormal_response_to0.68142727
91MP0002420_abnormal_adaptive_immunity0.67357106
92MP0003221_abnormal_cardiomyocyte_apopto0.67066971
93MP0001819_abnormal_immune_cell0.66975675
94MP0000681_abnormal_thyroid_gland0.66285081
95MP0002088_abnormal_embryonic_growth/wei0.66206226
96MP0000749_muscle_degeneration0.65082662
97MP0001919_abnormal_reproductive_system0.63765342
98MP0002166_altered_tumor_susceptibility0.62953173
99MP0001873_stomach_inflammation0.62890042
100MP0005319_abnormal_enzyme/_coenzyme0.62840083

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.77195965
2Acute encephalopathy (HP:0006846)4.52741397
3Abnormal mitochondria in muscle tissue (HP:0008316)4.48128267
4Mitochondrial inheritance (HP:0001427)4.18318976
5Increased CSF lactate (HP:0002490)4.09116726
6Progressive macrocephaly (HP:0004481)3.97234984
7Hepatocellular necrosis (HP:0001404)3.74212815
8Type I transferrin isoform profile (HP:0003642)3.66093650
9Hepatic necrosis (HP:0002605)3.53987853
10Cerebral edema (HP:0002181)3.51426339
11Increased intramyocellular lipid droplets (HP:0012240)3.50522563
12Increased hepatocellular lipid droplets (HP:0006565)3.40184993
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.37416987
14Abnormality of alanine metabolism (HP:0010916)3.37416987
15Hyperalaninemia (HP:0003348)3.37416987
16Lipid accumulation in hepatocytes (HP:0006561)3.33003207
17Lactic acidosis (HP:0003128)3.22327904
18Increased muscle lipid content (HP:0009058)3.18901974
19Increased serum lactate (HP:0002151)3.18620357
20Renal Fanconi syndrome (HP:0001994)3.17114346
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.16766669
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.16766669
23Microvesicular hepatic steatosis (HP:0001414)3.08819613
24Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.06996087
25Abnormal protein N-linked glycosylation (HP:0012347)3.06996087
26Abnormal protein glycosylation (HP:0012346)3.06996087
27Abnormal glycosylation (HP:0012345)3.06996087
28Reduced antithrombin III activity (HP:0001976)3.03491381
29Increased serum pyruvate (HP:0003542)2.86179997
30Abnormality of glycolysis (HP:0004366)2.77088827
31Abnormality of methionine metabolism (HP:0010901)2.75395748
32B lymphocytopenia (HP:0010976)2.74907540
33Exercise intolerance (HP:0003546)2.74403468
34Respiratory failure (HP:0002878)2.71160826
35Abnormality of the heme biosynthetic pathway (HP:0010472)2.69797670
36Abnormality of B cell number (HP:0010975)2.66340020
37Abnormal number of erythroid precursors (HP:0012131)2.61905329
38Abnormality of chromosome stability (HP:0003220)2.59110735
39Abnormality of cells of the erythroid lineage (HP:0012130)2.57375998
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.52208272
413-Methylglutaconic aciduria (HP:0003535)2.49457617
42Lethargy (HP:0001254)2.47697274
43Rhabdomyolysis (HP:0003201)2.47496016
44Macrocytic anemia (HP:0001972)2.46075854
45Abnormality of renal resorption (HP:0011038)2.42557539
46Chromsome breakage (HP:0040012)2.41768985
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.37781787
48Exertional dyspnea (HP:0002875)2.36296374
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31133986
50Dicarboxylic aciduria (HP:0003215)2.31133986
51Reticulocytopenia (HP:0001896)2.29112833
52Microretrognathia (HP:0000308)2.28782485
53Abnormality of serum amino acid levels (HP:0003112)2.25248104
54Respiratory difficulties (HP:0002880)2.23317223
55Abnormality of the preputium (HP:0100587)2.23250031
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22092731
57Petechiae (HP:0000967)2.20446843
58Degeneration of anterior horn cells (HP:0002398)2.19123042
59Abnormality of the anterior horn cell (HP:0006802)2.19123042
60Leukodystrophy (HP:0002415)2.16464640
61Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15926400
62Optic disc pallor (HP:0000543)2.15346139
63Aplastic anemia (HP:0001915)2.11022227
64Thrombocytosis (HP:0001894)2.10354782
65Pallor (HP:0000980)2.05339921
66Pancytopenia (HP:0001876)2.05299916
67Severe combined immunodeficiency (HP:0004430)2.02978694
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.02683892
69Methylmalonic aciduria (HP:0012120)2.00259840
70Rhabdomyosarcoma (HP:0002859)1.98680241
71Combined immunodeficiency (HP:0005387)1.97962318
72Delayed CNS myelination (HP:0002188)1.96832758
73Duodenal stenosis (HP:0100867)1.95426937
74Small intestinal stenosis (HP:0012848)1.95426937
75Spastic paraparesis (HP:0002313)1.94056539
76Testicular atrophy (HP:0000029)1.93415537
77Myoglobinuria (HP:0002913)1.93057971
78Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.93007066
79Palpitations (HP:0001962)1.91110291
80Meckel diverticulum (HP:0002245)1.90200172
81Cerebral hypomyelination (HP:0006808)1.89874291
82Myelodysplasia (HP:0002863)1.89728448
83CNS demyelination (HP:0007305)1.89132076
84Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88255971
85Methylmalonic acidemia (HP:0002912)1.87181007
86Abnormality of fatty-acid metabolism (HP:0004359)1.85703499
87Paralysis (HP:0003470)1.83059023
88Abnormality of the ileum (HP:0001549)1.80626608
89Metabolic acidosis (HP:0001942)1.79310454
90IgM deficiency (HP:0002850)1.77600997
91Ependymoma (HP:0002888)1.76445757
92Emotional lability (HP:0000712)1.75279721
93Nemaline bodies (HP:0003798)1.74579536
94Hypoparathyroidism (HP:0000829)1.74375564
95Autoimmune hemolytic anemia (HP:0001890)1.72059048
96Neutropenia (HP:0001875)1.70624827
97Hyperglycinemia (HP:0002154)1.70349787
98Generalized aminoaciduria (HP:0002909)1.69772240
99Aplasia/Hypoplasia of the thymus (HP:0010515)1.69596287
100Abnormality of the duodenum (HP:0002246)1.68550225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK3.84816675
2BUB13.73898248
3NEK13.32214397
4SCYL23.22637827
5EIF2AK13.14308174
6VRK22.93190753
7PLK42.68088892
8CDC72.55886571
9NME22.45625129
10EIF2AK32.44354011
11STK162.27552056
12BCKDK2.25105271
13TESK22.23978252
14TRIM282.15088286
15MAP4K22.05201643
16MST41.96581622
17VRK11.95918719
18SRPK11.94505862
19WEE11.94040771
20CDK191.77042591
21BRSK21.67311529
22BMPR1B1.61641731
23KDR1.59101904
24PDK21.57361549
25NUAK11.49657436
26ZAK1.49344257
27TLK11.42454560
28CCNB11.36817066
29ACVR1B1.35853420
30MAP3K121.34819069
31PLK11.32992637
32TTK1.23445467
33RPS6KB21.22774397
34TESK11.18244379
35AURKB1.13748442
36PIM21.09343597
37FLT31.08998077
38ATR1.06911807
39OBSCN0.99968098
40PLK30.99634345
41BMPR20.96701607
42PASK0.96177646
43RPS6KA40.94591842
44SIK30.92422434
45BRSK10.90415090
46NEK20.89795835
47MARK30.84778632
48TEC0.79538882
49PINK10.77431972
50RPS6KA50.75194328
51AURKA0.75120320
52STK40.74642829
53DAPK10.72013939
54MKNK10.71273275
55PIK3CG0.71156156
56CDK70.70726898
57PLK20.70019205
58TAOK30.69638450
59CHEK10.69174478
60CSNK2A20.68901434
61ERBB30.67308118
62EIF2AK20.66300552
63STK100.66131822
64ERBB40.64973423
65CHEK20.64187358
66KIT0.62344310
67MAP3K80.61432073
68CSNK2A10.61182262
69ATM0.60779798
70LIMK10.59579327
71NME10.57747903
72PAK40.53977042
73PRKCI0.51098431
74TGFBR10.50240578
75CLK10.47488165
76PAK10.45858519
77CSF1R0.44276186
78CSNK1G30.42994745
79CDK40.42835752
80LRRK20.39023345
81BRD40.38580899
82RIPK40.37445677
83RAF10.36966334
84SYK0.35944116
85PIM10.35338677
86ABL20.33211488
87IKBKB0.31635291
88ARAF0.31558324
89TYK20.30599390
90BTK0.30444829
91ILK0.30204167
92GRK10.29079870
93CDK20.28938137
94GRK60.28808067
95CDK10.26945038
96CDK80.25979024
97MAP4K10.24947776
98TBK10.23004271
99TXK0.22493173
100LYN0.22049849

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.83156664
2Proteasome_Homo sapiens_hsa030503.79717451
3Ribosome_Homo sapiens_hsa030103.73367691
4Mismatch repair_Homo sapiens_hsa034303.37329127
5Oxidative phosphorylation_Homo sapiens_hsa001903.07104369
6Non-homologous end-joining_Homo sapiens_hsa034502.99682649
7Parkinsons disease_Homo sapiens_hsa050122.89009817
8Homologous recombination_Homo sapiens_hsa034402.73465091
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54926666
10Protein export_Homo sapiens_hsa030602.43247401
11One carbon pool by folate_Homo sapiens_hsa006702.37359409
12Base excision repair_Homo sapiens_hsa034102.37058966
13Nucleotide excision repair_Homo sapiens_hsa034202.23943389
14RNA polymerase_Homo sapiens_hsa030202.22621324
15Pyrimidine metabolism_Homo sapiens_hsa002402.16402446
16Huntingtons disease_Homo sapiens_hsa050161.93891198
17Fanconi anemia pathway_Homo sapiens_hsa034601.91055741
18Spliceosome_Homo sapiens_hsa030401.83017491
19RNA transport_Homo sapiens_hsa030131.82122051
20Alzheimers disease_Homo sapiens_hsa050101.71493505
21Fatty acid elongation_Homo sapiens_hsa000621.70430460
22RNA degradation_Homo sapiens_hsa030181.66697056
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64214743
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61918494
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59108521
26Propanoate metabolism_Homo sapiens_hsa006401.58242855
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55327354
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48108472
29Basal transcription factors_Homo sapiens_hsa030221.41461525
30Sulfur metabolism_Homo sapiens_hsa009201.39785252
31Cell cycle_Homo sapiens_hsa041101.36050255
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35137492
33Purine metabolism_Homo sapiens_hsa002301.33081279
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32468624
35Pyruvate metabolism_Homo sapiens_hsa006201.23493482
36Glutathione metabolism_Homo sapiens_hsa004801.22415524
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21968751
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.16594242
39Carbon metabolism_Homo sapiens_hsa012001.13796043
40Asthma_Homo sapiens_hsa053101.12055941
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08498253
42Peroxisome_Homo sapiens_hsa041461.07811037
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03394207
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01649137
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87744526
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86089305
47Pentose phosphate pathway_Homo sapiens_hsa000300.85284538
48Systemic lupus erythematosus_Homo sapiens_hsa053220.83737429
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79047793
50Metabolic pathways_Homo sapiens_hsa011000.79025572
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.78466764
52Folate biosynthesis_Homo sapiens_hsa007900.78413191
53Biosynthesis of amino acids_Homo sapiens_hsa012300.77993697
54Sulfur relay system_Homo sapiens_hsa041220.76584269
55N-Glycan biosynthesis_Homo sapiens_hsa005100.76356026
56Cardiac muscle contraction_Homo sapiens_hsa042600.75885459
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69828787
58mRNA surveillance pathway_Homo sapiens_hsa030150.69294863
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68942826
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.65363622
61Primary immunodeficiency_Homo sapiens_hsa053400.64402878
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63475810
63Fatty acid metabolism_Homo sapiens_hsa012120.63144256
64p53 signaling pathway_Homo sapiens_hsa041150.62417818
65Tyrosine metabolism_Homo sapiens_hsa003500.58724252
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56828257
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56814070
68Phenylalanine metabolism_Homo sapiens_hsa003600.51650065
69Epstein-Barr virus infection_Homo sapiens_hsa051690.49992389
70Fatty acid degradation_Homo sapiens_hsa000710.48561807
71Selenocompound metabolism_Homo sapiens_hsa004500.48408671
72Allograft rejection_Homo sapiens_hsa053300.48137021
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46745198
74Galactose metabolism_Homo sapiens_hsa000520.46625812
75Butanoate metabolism_Homo sapiens_hsa006500.44726631
76Oocyte meiosis_Homo sapiens_hsa041140.44139122
77Autoimmune thyroid disease_Homo sapiens_hsa053200.41807989
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39980441
79Collecting duct acid secretion_Homo sapiens_hsa049660.39131773
80beta-Alanine metabolism_Homo sapiens_hsa004100.35475694
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34019389
82Herpes simplex infection_Homo sapiens_hsa051680.32502843
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30740370
84Steroid biosynthesis_Homo sapiens_hsa001000.29965919
85Hematopoietic cell lineage_Homo sapiens_hsa046400.29592173
86Graft-versus-host disease_Homo sapiens_hsa053320.28910663
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27562129
88Antigen processing and presentation_Homo sapiens_hsa046120.26942758
89Regulation of autophagy_Homo sapiens_hsa041400.26119411
90Shigellosis_Homo sapiens_hsa051310.23847978
91Type I diabetes mellitus_Homo sapiens_hsa049400.22462600
92Chemical carcinogenesis_Homo sapiens_hsa052040.21829433
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21155420
94Fructose and mannose metabolism_Homo sapiens_hsa000510.20768986
95Viral carcinogenesis_Homo sapiens_hsa052030.16740365
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16332065
97Phototransduction_Homo sapiens_hsa047440.15915736
98Arginine and proline metabolism_Homo sapiens_hsa003300.15789269
99Alcoholism_Homo sapiens_hsa050340.15441438
100Viral myocarditis_Homo sapiens_hsa054160.15434921

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »