ATP2A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)6.08436621
2sarcomere organization (GO:0045214)5.92597286
3regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.91013295
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.78647839
5cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.67376199
6negative regulation of potassium ion transmembrane transport (GO:1901380)5.65066021
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.48961470
8regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.46585412
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.27667144
10cardiac muscle contraction (GO:0060048)5.14009366
11myofibril assembly (GO:0030239)5.13720936
12plasma membrane repair (GO:0001778)5.05168331
13cell communication by electrical coupling (GO:0010644)4.98453303
14cell communication involved in cardiac conduction (GO:0086065)4.84572606
15regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.74687528
16ventricular cardiac muscle cell action potential (GO:0086005)4.50651928
17regulation of actin filament-based movement (GO:1903115)4.48446227
18regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.44944532
19regulation of membrane repolarization (GO:0060306)4.38974657
20tricarboxylic acid cycle (GO:0006099)4.32000872
21cardiac muscle cell development (GO:0055013)4.15533822
22detection of calcium ion (GO:0005513)4.13035285
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.12850293
24cardiac muscle hypertrophy (GO:0003300)4.06626650
25regulation of cell communication by electrical coupling (GO:0010649)4.03836294
26skeletal muscle contraction (GO:0003009)4.01885575
27muscle filament sliding (GO:0030049)4.00135995
28actin-myosin filament sliding (GO:0033275)4.00135995
29response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.99342103
30regulation of relaxation of muscle (GO:1901077)3.97893997
31actomyosin structure organization (GO:0031032)3.97406734
32cardiac cell development (GO:0055006)3.86836585
33striated muscle hypertrophy (GO:0014897)3.86199523
34adult heart development (GO:0007512)3.84233869
35positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.81795008
36striated muscle contraction (GO:0006941)3.80949644
37membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.77385502
38regulation of striated muscle contraction (GO:0006942)3.77136774
39regulation of sarcomere organization (GO:0060297)3.69307891
40cardiac conduction (GO:0061337)3.64235138
41regulation of cardiac muscle cell contraction (GO:0086004)3.58345971
42cytoskeletal anchoring at plasma membrane (GO:0007016)3.57915700
43bundle of His cell to Purkinje myocyte communication (GO:0086069)3.57038202
44regulation of calcium ion transmembrane transporter activity (GO:1901019)3.55899539
45regulation of calcium ion transmembrane transport (GO:1903169)3.55899539
46desmosome organization (GO:0002934)3.54086461
47heart trabecula formation (GO:0060347)3.50827704
48regulation of cardiac muscle contraction (GO:0055117)3.49932867
49positive regulation of potassium ion transmembrane transport (GO:1901381)3.49928923
50cardiac muscle tissue morphogenesis (GO:0055008)3.48693001
51regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.48553462
52cell-substrate adherens junction assembly (GO:0007045)3.46413753
53focal adhesion assembly (GO:0048041)3.46413753
54cardiac muscle cell action potential involved in contraction (GO:0086002)3.45432659
55ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.45023870
56regulation of heart rate by cardiac conduction (GO:0086091)3.43423023
57potassium ion import (GO:0010107)3.43398514
58cardiac muscle cell action potential (GO:0086001)3.42508698
59carnitine shuttle (GO:0006853)3.39804290
60* regulation of the force of heart contraction (GO:0002026)3.39466156
61creatine metabolic process (GO:0006600)3.38370433
62response to inactivity (GO:0014854)3.36303341
63negative regulation of potassium ion transport (GO:0043267)3.36038214
64membrane repolarization during action potential (GO:0086011)3.35622113
65positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.35225966
66negative regulation of cytosolic calcium ion concentration (GO:0051481)3.34094826
67sodium ion export (GO:0071436)3.33205657
68adherens junction assembly (GO:0034333)3.32739799
69actin-mediated cell contraction (GO:0070252)3.31524185
70activation of protein kinase A activity (GO:0034199)3.30758929
71muscle hypertrophy (GO:0014896)3.30332964
72positive regulation of cation channel activity (GO:2001259)3.30253003
73cell-substrate junction assembly (GO:0007044)3.29749024
74regulation of acyl-CoA biosynthetic process (GO:0050812)3.29710979
75muscle contraction (GO:0006936)3.27959298
76regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.26491282
77hemidesmosome assembly (GO:0031581)3.18272853
78membrane repolarization (GO:0086009)3.15543566
79* relaxation of cardiac muscle (GO:0055119)3.15119430
80regulation of skeletal muscle contraction (GO:0014819)3.14286098
81* regulation of heart rate (GO:0002027)3.12158165
82muscle tissue morphogenesis (GO:0060415)3.11108272
83regulation of synapse structural plasticity (GO:0051823)3.10148838
84neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.07521714
85regulation of cofactor metabolic process (GO:0051193)3.06073618
86regulation of coenzyme metabolic process (GO:0051196)3.06073618
87muscle hypertrophy in response to stress (GO:0003299)3.05371739
88cardiac muscle adaptation (GO:0014887)3.05371739
89cardiac muscle hypertrophy in response to stress (GO:0014898)3.05371739
90* regulation of heart contraction (GO:0008016)3.04410437
91positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.04049202
92regulation of potassium ion transmembrane transport (GO:1901379)3.03881969
93positive regulation of potassium ion transport (GO:0043268)3.03499804
94striated muscle adaptation (GO:0014888)3.02810146
95regulation of short-term neuronal synaptic plasticity (GO:0048172)3.01765014
96growth hormone secretion (GO:0030252)2.98632857
97synaptic vesicle maturation (GO:0016188)2.98583311
98locomotory exploration behavior (GO:0035641)2.98102474
99* sarcoplasmic reticulum calcium ion transport (GO:0070296)2.97587019
100regulation of potassium ion transmembrane transporter activity (GO:1901016)2.95105998
101response to muscle activity (GO:0014850)2.92541799
102synaptic vesicle docking involved in exocytosis (GO:0016081)2.92374296
103regulation of cation channel activity (GO:2001257)2.91552097
104positive regulation of myotube differentiation (GO:0010831)2.90971550
105* muscle system process (GO:0003012)2.88820866
106regulation of NFAT protein import into nucleus (GO:0051532)2.86687229
107fatty acid transmembrane transport (GO:1902001)2.85102003
108NADH metabolic process (GO:0006734)2.84267596
109regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.80627688
110negative regulation of protein localization to cell surface (GO:2000009)2.79893417
111cellular potassium ion homeostasis (GO:0030007)2.79560677
112epithelial cell-cell adhesion (GO:0090136)2.79243036
113positive regulation of ion transmembrane transporter activity (GO:0032414)2.76254050
114negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.75791117
115negative regulation of calcium ion transmembrane transport (GO:1903170)2.75791117
116positive regulation of sodium ion transport (GO:0010765)2.69568997
117membrane depolarization during action potential (GO:0086010)2.67220178
118actin filament-based movement (GO:0030048)2.66573392
119regulation of cardioblast differentiation (GO:0051890)2.65137623
120multicellular organismal signaling (GO:0035637)2.64850827
121skeletal muscle adaptation (GO:0043501)2.61509176
122cellular sodium ion homeostasis (GO:0006883)2.54035064
123skeletal muscle fiber development (GO:0048741)2.52179921
124muscle cell cellular homeostasis (GO:0046716)2.51231086
125cellular response to epinephrine stimulus (GO:0071872)2.49847420
126negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.44888297
127myoblast fusion (GO:0007520)2.44340234
128planar cell polarity pathway involved in neural tube closure (GO:0090179)2.42677327
129atrioventricular valve morphogenesis (GO:0003181)2.41673397
130cerebellar granule cell differentiation (GO:0021707)2.41560412
131myotube differentiation (GO:0014902)2.41347628
132striated muscle cell development (GO:0055002)2.41265585
133negative regulation of cell size (GO:0045792)2.40298807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.86231218
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.71960249
3EP300_21415370_ChIP-Seq_HL-1_Mouse2.86345827
4DROSHA_22980978_ChIP-Seq_HELA_Human2.45511504
5* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.44230634
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.43708891
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40884704
8* CLOCK_20551151_ChIP-Seq_293T_Human2.35621232
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.19292648
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.18391004
11* TBX20_22328084_ChIP-Seq_HEART_Mouse2.04361074
12* TBX20_22080862_ChIP-Seq_HEART_Mouse2.04361074
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03052338
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03052338
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02055739
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97281240
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.90347530
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89497678
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89453003
20GBX2_23144817_ChIP-Seq_PC3_Human1.83577008
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83473466
22ZNF263_19887448_ChIP-Seq_K562_Human1.80930667
23RACK7_27058665_Chip-Seq_MCF-7_Human1.80786398
24RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.75504289
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71950078
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.69532943
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68811423
28REST_21632747_ChIP-Seq_MESCs_Mouse1.68275279
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.67527334
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66449736
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.65914876
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65766698
33LXR_22292898_ChIP-Seq_THP-1_Human1.65645176
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65309695
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63569187
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62939221
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62132397
38P300_27058665_Chip-Seq_ZR-75-30cells_Human1.61015432
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59523486
40* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.58445320
41ZNF274_21170338_ChIP-Seq_K562_Hela1.57958396
42NFIB_24661679_ChIP-Seq_LUNG_Mouse1.54192529
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.53906020
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.53390128
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.53330304
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.51460589
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51426154
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48427399
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47159605
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43577076
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43135766
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41879370
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.39396769
54TCF7_22412390_ChIP-Seq_EML_Mouse1.38958966
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38540171
56KDM2B_26808549_Chip-Seq_K562_Human1.36712072
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.36703476
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36055986
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35126904
60SMAD4_21799915_ChIP-Seq_A2780_Human1.32510128
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.32426360
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32359097
63NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.30543151
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.29225445
65* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28745536
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27217084
67* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.27125790
68* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26783897
69DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26225622
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26193334
71ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25882658
72AR_19668381_ChIP-Seq_PC3_Human1.25530852
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24522553
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22142265
75* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21666759
76CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21344720
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20238069
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.19771682
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19515710
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18333583
81AHR_22903824_ChIP-Seq_MCF-7_Human1.16685089
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.16335994
83TP53_23651856_ChIP-Seq_MEFs_Mouse1.15651426
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15618179
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.15376662
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14791452
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14572654
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13598813
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12413583
90CREB1_26743006_Chip-Seq_LNCaP_Human1.12375985
91* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10224671
92SMAD3_21741376_ChIP-Seq_HESCs_Human1.09906660
93DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09284759
94TP53_16413492_ChIP-PET_HCT116_Human1.08818754
95ISL1_27105846_Chip-Seq_CPCs_Mouse1.08698089
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08221681
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08199507
98SMC4_20622854_ChIP-Seq_HELA_Human1.07875191
99* SMAD4_21741376_ChIP-Seq_HESCs_Human1.07643308
100AR_21572438_ChIP-Seq_LNCaP_Human1.07594044
101PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05761433
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.05703248
103BCAT_22108803_ChIP-Seq_LS180_Human1.05399344
104SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04928176
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04672470
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04424216
107KDM2B_26808549_Chip-Seq_JURKAT_Human1.03940676
108SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03589595
109SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03589595
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03549208
111CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03216774
112SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02011670
113* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01925326
114GATA1_22025678_ChIP-Seq_K562_Human1.01762800
115* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.01544969
116FOXA2_19822575_ChIP-Seq_HepG2_Human1.01425884
117STAT3_23295773_ChIP-Seq_U87_Human1.00980459
118KDM2B_26808549_Chip-Seq_DND41_Human1.00481462
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.00478695
120YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99987536
121* UBF1/2_26484160_Chip-Seq_HMECs_Human0.99845074
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98989890
123ERG_21242973_ChIP-ChIP_JURKAT_Human0.98949394
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98745646
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98685874
126* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98674756
127CTCF_27219007_Chip-Seq_Bcells_Human0.98265028
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94901994
129PIAS1_25552417_ChIP-Seq_VCAP_Human0.94202544
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94164471
131GATA1_19941826_ChIP-Seq_K562_Human0.90601983
132* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90543151
133TCF4_23295773_ChIP-Seq_U87_Human0.88842268
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88515166
135SMAD3_21741376_ChIP-Seq_EPCs_Human0.88456558
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87598457
137RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87015094
138NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86909177
139CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85606130
140TRIM28_21343339_ChIP-Seq_HEK293_Human0.83929294
141ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83746367
142TET1_21490601_ChIP-Seq_MESCs_Mouse0.83720159
143MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82278206

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.28887021
2MP0000751_myopathy4.45345765
3* MP0004084_abnormal_cardiac_muscle4.35865754
4MP0003646_muscle_fatigue4.27285620
5* MP0004215_abnormal_myocardial_fiber4.14745442
6* MP0004036_abnormal_muscle_relaxation3.30770357
7MP0005330_cardiomyopathy3.18232927
8MP0000749_muscle_degeneration2.91896509
9MP0004859_abnormal_synaptic_plasticity2.82983149
10MP0003137_abnormal_impulse_conducting2.71194511
11* MP0002972_abnormal_cardiac_muscle2.63557287
12* MP0004087_abnormal_muscle_fiber2.51937501
13MP0004145_abnormal_muscle_electrophysio2.42942582
14MP0005451_abnormal_body_composition2.29729416
15* MP0005620_abnormal_muscle_contractility2.26510595
16MP0002909_abnormal_adrenal_gland2.24020726
17MP0004130_abnormal_muscle_cell2.23986860
18* MP0004085_abnormal_heartbeat2.21471386
19MP0004510_myositis2.13603274
20MP0009780_abnormal_chondrocyte_physiolo2.12506213
21* MP0004484_altered_response_of2.03630527
22* MP0010630_abnormal_cardiac_muscle2.01489144
23* MP0001544_abnormal_cardiovascular_syste2.00992422
24* MP0005385_cardiovascular_system_phenoty2.00992422
25MP0002106_abnormal_muscle_physiology2.00427361
26* MP0008775_abnormal_heart_ventricle1.99832007
27MP0002269_muscular_atrophy1.98431891
28MP0000733_abnormal_muscle_development1.93703189
29MP0000750_abnormal_muscle_regeneration1.91078211
30MP0005409_darkened_coat_color1.85971113
31MP0004233_abnormal_muscle_weight1.85870437
32MP0008438_abnormal_cutaneous_collagen1.84382339
33MP0003635_abnormal_synaptic_transmissio1.83959451
34MP0000747_muscle_weakness1.82890371
35* MP0006138_congestive_heart_failure1.79620328
36MP0004272_abnormal_basement_membrane1.76838228
37MP0004270_analgesia1.74476630
38MP0005369_muscle_phenotype1.66390091
39MP0000759_abnormal_skeletal_muscle1.58014293
40MP0010234_abnormal_vibrissa_follicle1.52562378
41MP0000013_abnormal_adipose_tissue1.51488561
42MP0002234_abnormal_pharynx_morphology1.46549588
43MP0004043_abnormal_pH_regulation1.45975496
44MP0003221_abnormal_cardiomyocyte_apopto1.40208506
45MP0003283_abnormal_digestive_organ1.39494426
46MP0009046_muscle_twitch1.37324198
47MP0009745_abnormal_behavioral_response1.33297588
48MP0002063_abnormal_learning/memory/cond1.31190449
49MP0002877_abnormal_melanocyte_morpholog1.27394910
50MP0003941_abnormal_skin_development1.27216475
51MP0002127_abnormal_cardiovascular_syste1.26636714
52MP0008961_abnormal_basal_metabolism1.24673766
53MP0002064_seizures1.22755991
54MP0008569_lethality_at_weaning1.22692230
55MP0002822_catalepsy1.21544739
56MP0003091_abnormal_cell_migration1.19774932
57MP0003880_abnormal_central_pattern1.19392121
58MP0005623_abnormal_meninges_morphology1.15985665
59MP0005275_abnormal_skin_tensile1.13450596
60MP0002272_abnormal_nervous_system1.10854469
61MP0000762_abnormal_tongue_morphology1.10355729
62MP0005666_abnormal_adipose_tissue1.10062588
63MP0010352_gastrointestinal_tract_polyps1.08130525
64MP0001849_ear_inflammation1.08023494
65MP0005076_abnormal_cell_differentiation1.07260513
66MP0003329_amyloid_beta_deposits1.04228505
67MP0002572_abnormal_emotion/affect_behav1.02089786
68MP0000003_abnormal_adipose_tissue1.01721321
69MP0002896_abnormal_bone_mineralization0.99710413
70MP0006036_abnormal_mitochondrial_physio0.98844539
71MP0005375_adipose_tissue_phenotype0.97631488
72MP0001348_abnormal_lacrimal_gland0.97523264
73MP0001440_abnormal_grooming_behavior0.96715289
74MP0001661_extended_life_span0.96327950
75MP0004858_abnormal_nervous_system0.94928068
76MP0002734_abnormal_mechanical_nocicepti0.92878668
77* MP0000266_abnormal_heart_morphology0.91135080
78MP0002332_abnormal_exercise_endurance0.90587953
79* MP0005386_behavior/neurological_phenoty0.89525853
80* MP0004924_abnormal_behavior0.89525853
81MP0000537_abnormal_urethra_morphology0.86763460
82MP0002078_abnormal_glucose_homeostasis0.85587258
83MP0001486_abnormal_startle_reflex0.82723638
84* MP0003828_pulmonary_edema0.82419426
85MP0001958_emphysema0.82039870
86MP0003453_abnormal_keratinocyte_physiol0.81700902
87MP0004185_abnormal_adipocyte_glucose0.80687318
88MP0009672_abnormal_birth_weight0.79357388
89MP0005535_abnormal_body_temperature0.79049550
90MP0003045_fibrosis0.77847426
91MP0003705_abnormal_hypodermis_morpholog0.75513184
92MP0002108_abnormal_muscle_morphology0.75084458
93* MP0002067_abnormal_sensory_capabilities0.74904401
94MP0003633_abnormal_nervous_system0.74423055
95MP0000534_abnormal_ureter_morphology0.73721163
96MP0005023_abnormal_wound_healing0.73622477
97MP0005503_abnormal_tendon_morphology0.72988131
98* MP0000230_abnormal_systemic_arterial0.72139407
99MP0000767_abnormal_smooth_muscle0.71870339
100MP0009384_cardiac_valve_regurgitation0.71629531
101MP0001346_abnormal_lacrimal_gland0.70868202
102MP0010368_abnormal_lymphatic_system0.70447042
103MP0002249_abnormal_larynx_morphology0.69987740
104MP0001970_abnormal_pain_threshold0.69764753
105MP0003567_abnormal_fetal_cardiomyocyte0.69641811
106MP0002971_abnormal_brown_adipose0.69507243
107MP0005670_abnormal_white_adipose0.68985393
108* MP0000579_abnormal_nail_morphology0.68487017
109MP0002089_abnormal_postnatal_growth/wei0.68103950
110MP0002060_abnormal_skin_morphology0.67934399
111MP0001501_abnormal_sleep_pattern0.66991207
112MP0002733_abnormal_thermal_nociception0.66782312
113MP0002693_abnormal_pancreas_physiology0.66326076
114* MP0002128_abnormal_blood_circulation0.66302733
115MP0001968_abnormal_touch/_nociception0.65880125
116MP0005257_abnormal_intraocular_pressure0.65873391
117MP0002735_abnormal_chemical_nociception0.65823206
118MP0004811_abnormal_neuron_physiology0.65379360
119MP0002796_impaired_skin_barrier0.65235592
120MP0003950_abnormal_plasma_membrane0.65137472
121MP0001299_abnormal_eye_distance/0.63911073
122* MP0002066_abnormal_motor_capabilities/c0.63456629
123* MP0005165_increased_susceptibility_to0.62341441
124MP0003634_abnormal_glial_cell0.62236332
125MP0003879_abnormal_hair_cell0.60954056
126MP0005167_abnormal_blood-brain_barrier0.60016076
127MP0006035_abnormal_mitochondrial_morpho0.58758502
128MP0000678_abnormal_parathyroid_gland0.57735880
129MP0002184_abnormal_innervation0.57662444
130MP0010030_abnormal_orbit_morphology0.56694813
131MP0002925_abnormal_cardiovascular_devel0.56517203
132MP0000566_synostosis0.55640784
133MP0003279_aneurysm0.55195137
134MP0000955_abnormal_spinal_cord0.54372798
135MP0005423_abnormal_somatic_nervous0.53780376
136MP0003566_abnormal_cell_adhesion0.53213476
137MP0003122_maternal_imprinting0.51892923
138MP0002557_abnormal_social/conspecific_i0.51627189
139MP0005266_abnormal_metabolism0.50794782
140MP0000462_abnormal_digestive_system0.50764987

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.39339246
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.89486948
3Muscle fiber inclusion bodies (HP:0100299)5.87981617
4Nemaline bodies (HP:0003798)5.81821890
5Ventricular tachycardia (HP:0004756)5.47435098
6Atrial fibrillation (HP:0005110)5.41461800
7Primary atrial arrhythmia (HP:0001692)5.11834090
8Bundle branch block (HP:0011710)5.03518300
9Calf muscle hypertrophy (HP:0008981)5.00594479
10Syncope (HP:0001279)4.94802622
11Supraventricular tachycardia (HP:0004755)4.87646366
12Supraventricular arrhythmia (HP:0005115)4.78526688
13Exercise-induced myalgia (HP:0003738)4.65365885
14Muscle hypertrophy of the lower extremities (HP:0008968)4.52526012
15Prolonged QT interval (HP:0001657)4.46254519
16Exercise-induced muscle cramps (HP:0003710)4.40549618
17Ventricular fibrillation (HP:0001663)4.39488474
18Abnormality of the calf musculature (HP:0001430)4.34076015
19Right ventricular cardiomyopathy (HP:0011663)4.27402658
20Distal lower limb muscle weakness (HP:0009053)4.22985549
21Muscle fiber splitting (HP:0003555)4.12168634
22Hyporeflexia of lower limbs (HP:0002600)4.08865206
23Lipoatrophy (HP:0100578)4.01731945
24Abnormality of the left ventricular outflow tract (HP:0011103)3.99369572
25Subaortic stenosis (HP:0001682)3.99369572
26Ventricular arrhythmia (HP:0004308)3.87975558
27Heart block (HP:0012722)3.79356473
28Myoglobinuria (HP:0002913)3.79262663
29Atrioventricular block (HP:0001678)3.65364863
30Abnormal atrioventricular conduction (HP:0005150)3.54628736
31Palpitations (HP:0001962)3.54131556
32Asymmetric septal hypertrophy (HP:0001670)3.43869967
33Dilated cardiomyopathy (HP:0001644)3.40873666
34Abnormal EKG (HP:0003115)3.36014070
35EMG: myopathic abnormalities (HP:0003458)3.34658510
36Myopathic facies (HP:0002058)3.30288686
37Dysmetric saccades (HP:0000641)3.21157101
38Ketoacidosis (HP:0001993)3.12565099
39Difficulty running (HP:0009046)3.02824953
40Myotonia (HP:0002486)3.02171919
41Hyperinsulinemic hypoglycemia (HP:0000825)2.98238289
42Round ear (HP:0100830)2.91291988
43Distal arthrogryposis (HP:0005684)2.82252617
44Increased connective tissue (HP:0009025)2.74574531
45Hypoglycemic coma (HP:0001325)2.72457112
46Pheochromocytoma (HP:0002666)2.70679298
47Left ventricular hypertrophy (HP:0001712)2.70260284
48Visual hallucinations (HP:0002367)2.60789223
49Focal motor seizures (HP:0011153)2.59208593
50Spinal rigidity (HP:0003306)2.58660900
51Rimmed vacuoles (HP:0003805)2.54023021
52Protrusio acetabuli (HP:0003179)2.53113312
53Ulnar deviation of the wrist (HP:0003049)2.51858695
54Difficulty climbing stairs (HP:0003551)2.46157951
55Increased variability in muscle fiber diameter (HP:0003557)2.39379919
56Large for gestational age (HP:0001520)2.38841552
57Neuroendocrine neoplasm (HP:0100634)2.26860564
58Calcaneovalgus deformity (HP:0001848)2.23259635
59Hamartoma of the eye (HP:0010568)2.17677766
60Areflexia of lower limbs (HP:0002522)2.17445797
61Rhabdomyolysis (HP:0003201)2.13691405
62Limb-girdle muscle atrophy (HP:0003797)2.13433951
63Focal seizures (HP:0007359)2.12856789
64Frequent falls (HP:0002359)2.12740938
65Obstructive sleep apnea (HP:0002870)2.12388565
66Arterial tortuosity (HP:0005116)2.10722162
67Hyperglycemia (HP:0003074)2.09968283
68EMG: neuropathic changes (HP:0003445)2.07367467
69Generalized muscle weakness (HP:0003324)2.07228216
70Testicular atrophy (HP:0000029)2.06230156
71Sudden cardiac death (HP:0001645)2.04164683
72Abnormality of skeletal muscle fiber size (HP:0012084)2.03313644
73Pancreatic islet-cell hyperplasia (HP:0004510)2.03259587
74Myokymia (HP:0002411)2.02937520
75Mildly elevated creatine phosphokinase (HP:0008180)2.02374702
76Premature rupture of membranes (HP:0001788)2.00181621
77Vascular tortuosity (HP:0004948)1.99849605
78Lower limb amyotrophy (HP:0007210)1.98589200
79Insulin-resistant diabetes mellitus (HP:0000831)1.98371676
80Action tremor (HP:0002345)1.96033487
81Dysdiadochokinesis (HP:0002075)1.95883091
82Abnormal social behavior (HP:0012433)1.95058004
83Impaired social interactions (HP:0000735)1.95058004
84Progressive muscle weakness (HP:0003323)1.94729732
85Ketosis (HP:0001946)1.93234382
86Poor eye contact (HP:0000817)1.92433478
87Rapidly progressive (HP:0003678)1.91831607
88Athetosis (HP:0002305)1.91177394
89Conjunctival hamartoma (HP:0100780)1.89128280
90Cerebral aneurysm (HP:0004944)1.88041300
91Deformed tarsal bones (HP:0008119)1.87398511
92Central scotoma (HP:0000603)1.85965775
93Bulbar palsy (HP:0001283)1.85829822
94* Palmoplantar keratoderma (HP:0000982)1.84817743
95Distal lower limb amyotrophy (HP:0008944)1.84000039
96Hyperacusis (HP:0010780)1.83014062
97Achilles tendon contracture (HP:0001771)1.82170899
98Atrophic scars (HP:0001075)1.81432960
99Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80881652
100Abnormality of the calcaneus (HP:0008364)1.80265631
101Abnormality of the foot musculature (HP:0001436)1.80222159
102Proximal amyotrophy (HP:0007126)1.79320690
103Lymphangioma (HP:0100764)1.79124688
104Neck muscle weakness (HP:0000467)1.78610679
105Hypoplastic ischia (HP:0003175)1.78348079
106Type 1 muscle fiber predominance (HP:0003803)1.77563444
107Anxiety (HP:0000739)1.76392917
108Resting tremor (HP:0002322)1.76155923
109Congestive heart failure (HP:0001635)1.73591620
110Fragile skin (HP:0001030)1.73352169
111Scapular winging (HP:0003691)1.73220788
112Bradycardia (HP:0001662)1.73018146
113Aortic aneurysm (HP:0004942)1.71313175
114Distal upper limb amyotrophy (HP:0007149)1.70860922
115Upper limb amyotrophy (HP:0009129)1.70860922
116Ragged-red muscle fibers (HP:0003200)1.70382172
117Hip contracture (HP:0003273)1.70312639
118Gowers sign (HP:0003391)1.70034306
119Muscle stiffness (HP:0003552)1.69834633
120Aneurysm (HP:0002617)1.69521418
121Foot dorsiflexor weakness (HP:0009027)1.69501508
122Hypoglycemic seizures (HP:0002173)1.68693799
123Slender build (HP:0001533)1.68004365
124Neoplasm of the adrenal gland (HP:0100631)1.67803964
125Broad metatarsal (HP:0001783)1.67716852
126Hyperkalemia (HP:0002153)1.67609225
127Neoplasm of the peripheral nervous system (HP:0100007)1.64731672
128Shallow orbits (HP:0000586)1.64721430
129Abnormality of the shoulder girdle musculature (HP:0001435)1.63202801
130Generalized tonic-clonic seizures (HP:0002069)1.61773939
131Abnormality of the Achilles tendon (HP:0005109)1.61765818
132Centrally nucleated skeletal muscle fibers (HP:0003687)1.61469580
133Back pain (HP:0003418)1.60621707
134Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.59960630
135Metatarsus adductus (HP:0001840)1.59729741
136Postural instability (HP:0002172)1.58940937
137Papilledema (HP:0001085)1.58532612
138Tinnitus (HP:0000360)1.57430614
139Limb-girdle muscle weakness (HP:0003325)1.57401607
140Abnormality of the tricuspid valve (HP:0001702)1.57325849
141Muscular dystrophy (HP:0003560)1.56496813
142Abnormality of endocrine pancreas physiology (HP:0012093)1.56057320
143Steppage gait (HP:0003376)1.55770802
144Ulnar bowing (HP:0003031)1.54597319
145Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.52001413

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.75084404
2LMTK23.21374864
3PHKG23.06482712
4PHKG13.06482712
5OBSCN2.93563939
6TRIB32.84443621
7EEF2K2.64985826
8DMPK2.63870720
9PKN22.63386195
10PDK32.46213214
11PDK42.46213214
12MYLK2.18447653
13NTRK32.15146420
14CDK122.13888155
15PRKD32.13141090
16INSRR1.85067917
17MAP3K41.81271385
18NEK11.78864186
19MAP3K91.75409543
20PRPF4B1.72591572
21EPHA41.70713893
22RIPK11.70064938
23PAK31.67857483
24SMG11.56963098
25PINK11.52816601
26PAK61.48906163
27SIK11.48643874
28STK381.47493938
29CDC42BPA1.46312577
30PIK3CA1.45189194
31KSR21.42643983
32MST1R1.41608085
33CAMKK11.35277901
34PDGFRA1.34839854
35EPHA21.29724678
36TRPM71.24686580
37PDK21.24298593
38MUSK1.23365759
39WNK11.18979323
40MARK11.18707729
41WNK41.18033568
42PRKD11.17995413
43MAP3K131.14311503
44MET1.13787595
45MAP2K41.13529846
46MTOR1.13187776
47ARAF1.10660099
48DAPK21.10488208
49PRKCH1.10380002
50FGFR41.09274666
51NTRK11.08560965
52CAMKK21.08096621
53STK241.07460465
54MINK11.07283789
55TIE11.07207500
56RET1.05312325
57MAPKAPK31.01577100
58MAP3K71.00724414
59ERN10.96579335
60CAMK1D0.95640433
61NEK90.93432871
62* CAMK2D0.93079210
63MAP3K20.91518016
64LIMK10.88115007
65PRKAA10.84858986
66BCKDK0.83496290
67CAMK10.83069010
68ROCK10.82961243
69MAP3K10.81484072
70UHMK10.81359035
71CAMK40.80319390
72* CAMK2A0.79693749
73MOS0.78388553
74EPHB10.77156618
75LATS20.76495052
76SGK30.76081089
77PDPK10.76000699
78DDR20.74040984
79CDK50.73805625
80TAOK10.73745889
81MAP3K50.73180242
82MAP3K100.71914213
83PDK10.70509665
84ALK0.69411821
85NTRK20.69308605
86PTK2B0.69197858
87CAMK1G0.68798223
88PIK3CG0.68326867
89ILK0.68263495
90STK110.67442381
91KSR10.66973922
92PAK20.65468592
93PTK60.65338969
94FER0.65319081
95AKT20.65049945
96MAP2K70.64440042
97PRKCE0.63799598
98GRK70.63638910
99MAPK120.62757642
100MAP3K60.61614058
101DAPK30.59908850
102MAP2K30.59572829
103ICK0.58757395
104MAPK100.58100132
105SGK10.57832222
106ROCK20.57448987
107IRAK30.56807436
108TESK10.56224250
109MAP2K10.55831521
110SGK20.54751823
111TYRO30.54174536
112MAPK110.50979276
113SCYL20.49921524
114PRKAA20.49780374
115PRKACG0.48418596
116HIPK20.47822069
117MAPK70.47548456
118AKT30.47227701
119MARK20.47063964
120SGK2230.46996767
121SGK4940.46996767
122LATS10.46049218
123PRKACB0.45121896
124RPS6KB20.44906318
125* CAMK2G0.44680322
126GRK50.44630422
127* RPS6KA30.44619092
128FGFR30.44430507
129PRKACA0.43505101
130RIPK40.43488295
131RAF10.40179667
132PAK40.39901783
133PRKCG0.39374076
134PDGFRB0.39166607
135PKN10.38425584
136BRAF0.38083349
137RPS6KL10.37177298
138RPS6KC10.37177298
139PNCK0.36934325
140BRD40.36628513
141PTK20.35836646
142RPS6KA20.35432279
143MAPKAPK50.35399829
144ERBB40.33840409
145PLK20.32221279

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.85664194
2* Dilated cardiomyopathy_Homo sapiens_hsa054142.83302231
3* Cardiac muscle contraction_Homo sapiens_hsa042602.76821012
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.47135030
5* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.42978667
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.29563278
7* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.15808147
8Insulin secretion_Homo sapiens_hsa049112.01399622
9Circadian entrainment_Homo sapiens_hsa047131.84703395
10Type II diabetes mellitus_Homo sapiens_hsa049301.78844018
11Long-term potentiation_Homo sapiens_hsa047201.78524084
12* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.76516093
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74422279
14GABAergic synapse_Homo sapiens_hsa047271.49550607
15Propanoate metabolism_Homo sapiens_hsa006401.49219306
16Gastric acid secretion_Homo sapiens_hsa049711.49123838
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.48529500
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47716834
19Amphetamine addiction_Homo sapiens_hsa050311.47351194
20Adherens junction_Homo sapiens_hsa045201.45625039
21Glutamatergic synapse_Homo sapiens_hsa047241.44420303
22ECM-receptor interaction_Homo sapiens_hsa045121.40779244
23Nicotine addiction_Homo sapiens_hsa050331.40204727
24Morphine addiction_Homo sapiens_hsa050321.39716614
25Renin secretion_Homo sapiens_hsa049241.38657771
26Olfactory transduction_Homo sapiens_hsa047401.38217205
27Oxytocin signaling pathway_Homo sapiens_hsa049211.37965793
28* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.36351549
29Fatty acid degradation_Homo sapiens_hsa000711.35189386
30Salivary secretion_Homo sapiens_hsa049701.34033034
31Dopaminergic synapse_Homo sapiens_hsa047281.28392879
32Cholinergic synapse_Homo sapiens_hsa047251.28024077
33Taste transduction_Homo sapiens_hsa047421.25723393
34Synaptic vesicle cycle_Homo sapiens_hsa047211.24334160
35Glucagon signaling pathway_Homo sapiens_hsa049221.24161977
36* Calcium signaling pathway_Homo sapiens_hsa040201.24021090
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21138047
38Prion diseases_Homo sapiens_hsa050201.17315203
39Carbon metabolism_Homo sapiens_hsa012001.15970004
40Parkinsons disease_Homo sapiens_hsa050121.10324265
41Fatty acid metabolism_Homo sapiens_hsa012121.09919394
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07635850
43* cAMP signaling pathway_Homo sapiens_hsa040241.07120366
44GnRH signaling pathway_Homo sapiens_hsa049121.04322139
45Amoebiasis_Homo sapiens_hsa051461.04246004
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.03965728
47Alzheimers disease_Homo sapiens_hsa050101.03606380
48Insulin resistance_Homo sapiens_hsa049311.03525572
49Proteoglycans in cancer_Homo sapiens_hsa052051.02877496
50Estrogen signaling pathway_Homo sapiens_hsa049151.02379977
51Gap junction_Homo sapiens_hsa045401.01808853
52Butanoate metabolism_Homo sapiens_hsa006501.00582517
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99344705
54Arginine and proline metabolism_Homo sapiens_hsa003300.97776349
55Pentose phosphate pathway_Homo sapiens_hsa000300.96728571
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96719186
57Insulin signaling pathway_Homo sapiens_hsa049100.96144174
58Cocaine addiction_Homo sapiens_hsa050300.96063519
59Chronic myeloid leukemia_Homo sapiens_hsa052200.95569143
60Oxidative phosphorylation_Homo sapiens_hsa001900.95529516
61Phenylalanine metabolism_Homo sapiens_hsa003600.94703060
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94234630
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94171251
64Biosynthesis of amino acids_Homo sapiens_hsa012300.93180966
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92327238
66Dorso-ventral axis formation_Homo sapiens_hsa043200.90757635
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90042723
68Thyroid cancer_Homo sapiens_hsa052160.87462113
69Long-term depression_Homo sapiens_hsa047300.85192885
70Fructose and mannose metabolism_Homo sapiens_hsa000510.81640157
71Nitrogen metabolism_Homo sapiens_hsa009100.81127181
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80686882
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80363632
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80047700
75* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79292419
76* Pancreatic secretion_Homo sapiens_hsa049720.78953675
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.78846222
78Viral myocarditis_Homo sapiens_hsa054160.78275161
79Bladder cancer_Homo sapiens_hsa052190.77689648
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77395622
81mTOR signaling pathway_Homo sapiens_hsa041500.76402072
82Pyruvate metabolism_Homo sapiens_hsa006200.76262356
83Non-small cell lung cancer_Homo sapiens_hsa052230.76121008
84Serotonergic synapse_Homo sapiens_hsa047260.76062069
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75084826
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.73376757
87Small cell lung cancer_Homo sapiens_hsa052220.71532472
88Thyroid hormone synthesis_Homo sapiens_hsa049180.70778286
89Pancreatic cancer_Homo sapiens_hsa052120.68339576
90Glioma_Homo sapiens_hsa052140.67710159
91AMPK signaling pathway_Homo sapiens_hsa041520.67397003
92Focal adhesion_Homo sapiens_hsa045100.65941292
93Melanogenesis_Homo sapiens_hsa049160.65933365
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63348505
95Choline metabolism in cancer_Homo sapiens_hsa052310.60589544
96Bile secretion_Homo sapiens_hsa049760.59818083
97Hippo signaling pathway_Homo sapiens_hsa043900.59785326
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.59404427
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59060724
100Circadian rhythm_Homo sapiens_hsa047100.58490206
101Huntingtons disease_Homo sapiens_hsa050160.58262172
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.58170648
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57508216
104Arginine biosynthesis_Homo sapiens_hsa002200.57285708
105MicroRNAs in cancer_Homo sapiens_hsa052060.57266338
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56331476
107VEGF signaling pathway_Homo sapiens_hsa043700.55228071
108Tight junction_Homo sapiens_hsa045300.55074639
109Notch signaling pathway_Homo sapiens_hsa043300.54679509
110Protein digestion and absorption_Homo sapiens_hsa049740.54610207
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.54147673
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52930912
113Lysine degradation_Homo sapiens_hsa003100.51815530
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51631655
115Prostate cancer_Homo sapiens_hsa052150.51236804
116Renal cell carcinoma_Homo sapiens_hsa052110.51215204
117HIF-1 signaling pathway_Homo sapiens_hsa040660.45901267
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45752983
119ErbB signaling pathway_Homo sapiens_hsa040120.44611082
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44440199
121MAPK signaling pathway_Homo sapiens_hsa040100.44337644
122Fatty acid biosynthesis_Homo sapiens_hsa000610.42757948
123Inositol phosphate metabolism_Homo sapiens_hsa005620.42454144
124Ovarian steroidogenesis_Homo sapiens_hsa049130.42389503
125Starch and sucrose metabolism_Homo sapiens_hsa005000.42148890
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.40175758
127PPAR signaling pathway_Homo sapiens_hsa033200.38101308
128Endometrial cancer_Homo sapiens_hsa052130.37737736

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