ATP2A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)8.32845298
2COPI coating of Golgi vesicle (GO:0048205)8.32845298
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.29971462
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.29971462
5antigen processing and presentation of endogenous antigen (GO:0019883)6.09246576
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.41081044
7regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.36005860
8positive regulation of gamma-delta T cell activation (GO:0046645)5.25771556
9endocrine pancreas development (GO:0031018)5.07218575
10positive thymic T cell selection (GO:0045059)4.86490227
11regulation of gamma-delta T cell differentiation (GO:0045586)4.82886630
12retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.82156877
13protein maturation by protein folding (GO:0022417)4.77960540
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.76710981
15activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.70134748
16positive regulation of nuclease activity (GO:0032075)4.58907165
17negative regulation of glycoprotein biosynthetic process (GO:0010561)4.55594927
18COPII vesicle coating (GO:0048208)4.49221064
19type B pancreatic cell development (GO:0003323)4.47396010
20positive regulation of histone deacetylation (GO:0031065)4.43667426
21negative regulation of bone resorption (GO:0045779)4.40271325
22detection of bacterium (GO:0016045)4.33039002
23regulation of gamma-delta T cell activation (GO:0046643)4.30513851
24regulation of nuclease activity (GO:0032069)4.27610219
25sequestering of metal ion (GO:0051238)4.26412875
26detection of other organism (GO:0098543)4.24154907
27neutrophil activation involved in immune response (GO:0002283)4.21427431
28peptide hormone processing (GO:0016486)4.19172606
29positive regulation by organism of defense response of other organism involved in symbiotic interact4.18511330
30modulation by symbiont of host immune response (GO:0052553)4.18511330
31positive regulation by symbiont of host defense response (GO:0052509)4.18511330
32modulation by symbiont of host defense response (GO:0052031)4.18511330
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.18511330
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.18511330
35glandular epithelial cell development (GO:0002068)4.17556223
36protein retention in ER lumen (GO:0006621)4.15494856
37B cell receptor signaling pathway (GO:0050853)4.00603633
38glandular epithelial cell differentiation (GO:0002067)3.97079017
39positive T cell selection (GO:0043368)3.93714794
40positive regulation of granulocyte differentiation (GO:0030854)3.91514226
41endoplasmic reticulum unfolded protein response (GO:0030968)3.90992299
42regulation of type B pancreatic cell apoptotic process (GO:2000674)3.79295371
43cellular response to unfolded protein (GO:0034620)3.77219388
44vesicle coating (GO:0006901)3.72628973
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.68708575
46immunoglobulin mediated immune response (GO:0016064)3.66821026
47germinal center formation (GO:0002467)3.65710561
48positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.62698754
49antigen processing and presentation via MHC class Ib (GO:0002475)3.62642256
50ER-nucleus signaling pathway (GO:0006984)3.60807584
51cellular response to topologically incorrect protein (GO:0035967)3.58893717
52cellular extravasation (GO:0045123)3.54878421
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.54129533
54thymic T cell selection (GO:0045061)3.51999073
55response to peptidoglycan (GO:0032494)3.50105776
56adaptation of signaling pathway (GO:0023058)3.49748961
57macrophage activation involved in immune response (GO:0002281)3.47741117
58exocrine pancreas development (GO:0031017)3.43919496
59response to muramyl dipeptide (GO:0032495)3.43722778
60JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.43215011
61positive regulation of insulin secretion (GO:0032024)3.40806590
62negative regulation of leukocyte mediated immunity (GO:0002704)3.40076005
63negative regulation of bone remodeling (GO:0046851)3.39952163
64positive regulation of B cell differentiation (GO:0045579)3.39752033
65tolerance induction (GO:0002507)3.38343724
66neutrophil activation (GO:0042119)3.34155715
67signal peptide processing (GO:0006465)3.29645240
68negative regulation of T cell mediated immunity (GO:0002710)3.29537169
69columnar/cuboidal epithelial cell development (GO:0002066)3.29527002
70regulation of B cell differentiation (GO:0045577)3.28756180
71T cell selection (GO:0045058)3.27390420
72regulation of interferon-beta biosynthetic process (GO:0045357)3.27252136
73positive regulation of protein deacetylation (GO:0090312)3.27135355
74respiratory burst (GO:0045730)3.25678327
75regulation of mast cell degranulation (GO:0043304)3.24990069
76cellular response to interleukin-15 (GO:0071350)3.24680002
77ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.21196107
78negative regulation of glycoprotein metabolic process (GO:1903019)3.19926201
79negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.18061075
80regulation of B cell receptor signaling pathway (GO:0050855)3.16398658
81detection of external biotic stimulus (GO:0098581)3.15051834
82insulin secretion (GO:0030073)3.14562614
83regulation of leukocyte degranulation (GO:0043300)3.11038474
84negative regulation of cell killing (GO:0031342)3.10841508
85negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.10841508
86regulation of granulocyte differentiation (GO:0030852)3.10712815
87response to type I interferon (GO:0034340)3.09764147
88positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.07888907
89type I interferon signaling pathway (GO:0060337)3.07496006
90cellular response to type I interferon (GO:0071357)3.07496006
91regulation of alpha-beta T cell proliferation (GO:0046640)3.07398259
92regulation of myeloid leukocyte mediated immunity (GO:0002886)3.04219174
93regulation of T cell tolerance induction (GO:0002664)3.04105826
94response to endoplasmic reticulum stress (GO:0034976)3.03986197
95response to interleukin-15 (GO:0070672)3.03356386
96defense response to protozoan (GO:0042832)3.02510879
97regulation of dendritic cell antigen processing and presentation (GO:0002604)3.02410145
98UDP-N-acetylglucosamine metabolic process (GO:0006047)3.01310341
99regulation of tolerance induction (GO:0002643)2.99806886
100intra-Golgi vesicle-mediated transport (GO:0006891)2.99758702
101positive regulation of Rap GTPase activity (GO:0032854)2.98391786
102granulocyte activation (GO:0036230)2.98262623
103peptidyl-asparagine modification (GO:0018196)2.98256264
104protein N-linked glycosylation via asparagine (GO:0018279)2.97811473
105myeloid cell activation involved in immune response (GO:0002275)2.95602946
106response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.94799763
107response to host immune response (GO:0052572)2.94799763
108production of molecular mediator involved in inflammatory response (GO:0002532)2.93711298
109negative regulation of interleukin-12 production (GO:0032695)2.93043358
110T cell homeostasis (GO:0043029)2.92812142
111regulation of mast cell activation involved in immune response (GO:0033006)2.92698978
112activated T cell proliferation (GO:0050798)2.92602334
113L-alpha-amino acid transmembrane transport (GO:1902475)2.92189943
114negative T cell selection (GO:0043383)2.90202519
115negative thymic T cell selection (GO:0045060)2.89165533
116response to protozoan (GO:0001562)2.88724377
117negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.88515192
118negative regulation of T-helper cell differentiation (GO:0045623)2.88515192
119mannose metabolic process (GO:0006013)2.88458930
120regulation of insulin secretion (GO:0050796)2.86678938
121B cell mediated immunity (GO:0019724)2.86094705
122regulation of natural killer cell mediated immunity (GO:0002715)2.86038791
123regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.86038791
124B cell homeostasis (GO:0001782)2.83552091
125leukocyte degranulation (GO:0043299)2.82288594
126regulation of antigen processing and presentation (GO:0002577)2.81505854
127lymphocyte homeostasis (GO:0002260)2.79720735
128interferon-gamma-mediated signaling pathway (GO:0060333)2.79038784
129negative regulation of erythrocyte differentiation (GO:0045647)2.78191966
130NIK/NF-kappaB signaling (GO:0038061)2.78169266
131response to host (GO:0075136)2.75278575
132response to host defenses (GO:0052200)2.75278575
133response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.75278575
134negative regulation of tissue remodeling (GO:0034104)2.74163053
135negative regulation of interleukin-6 production (GO:0032715)2.73691077
136cellular response to vitamin D (GO:0071305)2.73163887
137leukocyte aggregation (GO:0070486)2.73088237
138regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.72947547
139negative regulation of innate immune response (GO:0045824)2.71061562
140megakaryocyte development (GO:0035855)2.70920766
141protein N-linked glycosylation (GO:0006487)2.70139419
142T cell receptor signaling pathway (GO:0050852)2.67643783
143ER overload response (GO:0006983)2.67138486
144positive regulation of peptide hormone secretion (GO:0090277)2.64119619
145response to unfolded protein (GO:0006986)2.63758342
146regulation of Golgi to plasma membrane protein transport (GO:0042996)2.63665344
147negative regulation of phagocytosis (GO:0050765)2.60659995
148regulation of peptide hormone secretion (GO:0090276)2.56579973
149positive regulation of regulated secretory pathway (GO:1903307)2.56508873
150regulation of interleukin-12 biosynthetic process (GO:0045075)2.56458743
151antigen receptor-mediated signaling pathway (GO:0050851)2.53619333
152regulation of peptide secretion (GO:0002791)2.53035692
153response to topologically incorrect protein (GO:0035966)2.50323808
154interleukin-1-mediated signaling pathway (GO:0070498)2.50262723
155positive regulation of peptide secretion (GO:0002793)2.49914114
156regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.49826436
157Golgi organization (GO:0007030)2.47423140
158gland morphogenesis (GO:0022612)2.47413433
159Peyers patch development (GO:0048541)2.46294368
160mucosal-associated lymphoid tissue development (GO:0048537)2.46294368
161intestinal epithelial cell development (GO:0060576)2.45289583
162regulation of Rap GTPase activity (GO:0032317)2.41638161
163hepatocyte apoptotic process (GO:0097284)2.41609314
164retrograde transport, vesicle recycling within Golgi (GO:0000301)2.40860661
165protein autoprocessing (GO:0016540)2.39087959
166epithelial cell fate commitment (GO:0072148)2.36941027
167chaperone mediated protein folding requiring cofactor (GO:0051085)2.36813925
168T cell migration (GO:0072678)2.36441187
169protein targeting to Golgi (GO:0000042)2.35796620
170negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.35744557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.70491256
2MYC_22102868_ChIP-Seq_BL_Human4.19456403
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.83284938
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.80168739
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.37449268
6GATA1_22025678_ChIP-Seq_K562_Human3.33053111
7VDR_21846776_ChIP-Seq_THP-1_Human3.10199182
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.04874093
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.73409160
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.70679391
11* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.56626397
12SCL_19346495_ChIP-Seq_HPC-7_Human2.55894913
13MYB_26560356_Chip-Seq_TH2_Human2.49548214
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.44342813
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.43678209
16* TCF7_22412390_ChIP-Seq_EML_Mouse2.43526561
17* UTX_26944678_Chip-Seq_JUKART_Human2.39668848
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.37824245
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.27951056
20MAF_26560356_Chip-Seq_TH1_Human2.23506419
21VDR_24763502_ChIP-Seq_THP-1_Human2.20741727
22* MYB_26560356_Chip-Seq_TH1_Human2.19457587
23E2F7_22180533_ChIP-Seq_HELA_Human2.18660093
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.16127717
25* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.13569247
26DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.08677175
27* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.05459054
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03943718
29* RUNX_20019798_ChIP-Seq_JUKART_Human1.99994021
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97905991
31CIITA_25753668_ChIP-Seq_RAJI_Human1.97586586
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.97353003
33* SPI1_23127762_ChIP-Seq_K562_Human1.96120237
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86974213
35* GATA3_27048872_Chip-Seq_THYMUS_Human1.85599790
36* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85204602
37* KDM2B_26808549_Chip-Seq_DND41_Human1.85192452
38* RUNX1_22412390_ChIP-Seq_EML_Mouse1.82006015
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78193903
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.75245848
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.75070786
42* SPI1_23547873_ChIP-Seq_NB4_Human1.74796026
43* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.68359102
44* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67722189
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62873400
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61736068
47* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61644301
48GATA1_19941826_ChIP-Seq_K562_Human1.56056401
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54207002
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51855186
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51529662
52* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51141318
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48267453
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46029376
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.44109753
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42252517
57FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.42244289
58* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40644331
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38037963
60IRF8_21731497_ChIP-ChIP_J774_Mouse1.38023857
61LXR_22292898_ChIP-Seq_THP-1_Human1.36696677
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35738972
63* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.35484986
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34465301
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.34034475
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32196405
67* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32174593
68BCOR_27268052_Chip-Seq_Bcells_Human1.29360910
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28742984
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27594108
71BCL6_27268052_Chip-Seq_Bcells_Human1.26010995
72TFEB_21752829_ChIP-Seq_HELA_Human1.25662121
73MAF_26560356_Chip-Seq_TH2_Human1.25559888
74* NCOR1_26117541_ChIP-Seq_K562_Human1.24561939
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23540909
76* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19395686
77* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19131477
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17689215
79P68_20966046_ChIP-Seq_HELA_Human1.17037842
80* GATA1_19941827_ChIP-Seq_MEL_Mouse1.16143743
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15661243
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.15033364
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14374296
84IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12358928
85* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11692900
86SA1_27219007_Chip-Seq_ERYTHROID_Human1.11063736
87VDR_24787735_ChIP-Seq_THP-1_Human1.10289020
88* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08096590
89PU_27001747_Chip-Seq_BMDM_Mouse1.07638886
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07574248
91FOXM1_23109430_ChIP-Seq_U2OS_Human1.07534989
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07331985
93* GATA3_26560356_Chip-Seq_TH2_Human1.06317448
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05233232
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03900024
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03602279
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01965149
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.01538992
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01473823
100GATA2_19941826_ChIP-Seq_K562_Human1.01347132
101* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00573018
102* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00257438
103* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.98458436
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97728295
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97359899
106SMC4_20622854_ChIP-Seq_HELA_Human0.97271298
107* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95971129
108CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95399967
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93640362
110GATA6_25053715_ChIP-Seq_YYC3_Human0.92954203
111KDM2B_26808549_Chip-Seq_K562_Human0.92633004
112PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91980286
113* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91709232
114RUNX1_27514584_Chip-Seq_MCF-7_Human0.91281419
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91251452
116* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91017590
117SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.90795162
118* RACK7_27058665_Chip-Seq_MCF-7_Human0.89932752
119* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89526927
120EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.87477268
121RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87410566
122P300_27268052_Chip-Seq_Bcells_Human0.86711106
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85454670
124KDM5A_27292631_Chip-Seq_BREAST_Human0.85151831
125CTCF_26484167_Chip-Seq_Bcells_Mouse0.84730434
126CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84393659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.43768699
2MP0003300_gastrointestinal_ulcer3.49988365
3MP0002693_abnormal_pancreas_physiology3.38383683
4MP0002909_abnormal_adrenal_gland3.10739725
5MP0003283_abnormal_digestive_organ3.06581608
6MP0003183_abnormal_peptide_metabolism2.89239503
7MP0001944_abnormal_pancreas_morphology2.76024302
8MP0003866_abnormal_defecation2.71196490
9MP0001790_abnormal_immune_system2.55143144
10MP0005387_immune_system_phenotype2.55143144
11MP0003303_peritoneal_inflammation2.43242240
12MP0001835_abnormal_antigen_presentation2.38995437
13MP0003763_abnormal_thymus_physiology2.36823512
14MP0001986_abnormal_taste_sensitivity2.36276697
15MP0000685_abnormal_immune_system2.32376623
16MP0001800_abnormal_humoral_immune2.29844112
17MP0004043_abnormal_pH_regulation2.22480018
18MP0005671_abnormal_response_to2.14513888
19MP0000013_abnormal_adipose_tissue2.12545850
20MP0009780_abnormal_chondrocyte_physiolo2.10437422
21MP0000678_abnormal_parathyroid_gland2.02144357
22MP0004264_abnormal_extraembryonic_tissu1.98819074
23MP0008961_abnormal_basal_metabolism1.97460998
24MP0005000_abnormal_immune_tolerance1.96077444
25MP0005220_abnormal_exocrine_pancreas1.86272077
26MP0005310_abnormal_salivary_gland1.86025211
27MP0004381_abnormal_hair_follicle1.85666121
28MP0006054_spinal_hemorrhage1.83523798
29MP0002420_abnormal_adaptive_immunity1.83004839
30MP0002398_abnormal_bone_marrow1.80432975
31MP0002452_abnormal_antigen_presenting1.79248216
32MP0001819_abnormal_immune_cell1.78928329
33MP0005379_endocrine/exocrine_gland_phen1.77289312
34MP0002723_abnormal_immune_serum1.76232169
35MP0006082_CNS_inflammation1.72877221
36MP0010155_abnormal_intestine_physiology1.72234140
37MP0003172_abnormal_lysosome_physiology1.68823534
38MP0001873_stomach_inflammation1.64956585
39MP0005451_abnormal_body_composition1.62440757
40MP0002928_abnormal_bile_duct1.60245758
41MP0003191_abnormal_cellular_cholesterol1.60138038
42MP0003436_decreased_susceptibility_to1.59368575
43MP0000716_abnormal_immune_system1.58265943
44MP0002166_altered_tumor_susceptibility1.57612439
45MP0002078_abnormal_glucose_homeostasis1.56440086
46MP0002132_abnormal_respiratory_system1.55263663
47MP0005464_abnormal_platelet_physiology1.52209486
48MP0008260_abnormal_autophagy1.50588348
49MP0004947_skin_inflammation1.48437856
50MP0000703_abnormal_thymus_morphology1.42945726
51MP0008004_abnormal_stomach_pH1.42828676
52MP0004808_abnormal_hematopoietic_stem1.41657268
53MP0005025_abnormal_response_to1.41263699
54MP0001545_abnormal_hematopoietic_system1.40512054
55MP0005397_hematopoietic_system_phenotyp1.40512054
56MP0000465_gastrointestinal_hemorrhage1.39563721
57MP0001845_abnormal_inflammatory_respons1.38267189
58MP0002009_preneoplasia1.36344244
59MP0002722_abnormal_immune_system1.34373284
60MP0000003_abnormal_adipose_tissue1.33812615
61MP0003045_fibrosis1.33403172
62MP0005058_abnormal_lysosome_morphology1.33243443
63MP0002405_respiratory_system_inflammati1.30187622
64MP0002429_abnormal_blood_cell1.30142274
65MP0005076_abnormal_cell_differentiation1.29262823
66MP0000689_abnormal_spleen_morphology1.29031625
67MP0001765_abnormal_ion_homeostasis1.27845624
68MP0010234_abnormal_vibrissa_follicle1.27768008
69MP0002396_abnormal_hematopoietic_system1.25316764
70MP0003195_calcinosis1.25041862
71MP0010352_gastrointestinal_tract_polyps1.24965982
72MP0005075_abnormal_melanosome_morpholog1.23690207
73MP0002419_abnormal_innate_immunity1.19063483
74MP0009643_abnormal_urine_homeostasis1.17889588
75MP0002148_abnormal_hypersensitivity_rea1.17803649
76MP0001851_eye_inflammation1.16518944
77MP0000858_altered_metastatic_potential1.15270785
78MP0000490_abnormal_crypts_of1.13976359
79MP0009333_abnormal_splenocyte_physiolog1.12734199
80MP0009785_altered_susceptibility_to1.07280429
81MP0010386_abnormal_urinary_bladder1.02613710
82MP0009278_abnormal_bone_marrow1.02499987
83MP0002998_abnormal_bone_remodeling0.98953799
84MP0003828_pulmonary_edema0.98633663
85MP0003566_abnormal_cell_adhesion0.97211838
86MP0000462_abnormal_digestive_system0.95877723
87MP0002933_joint_inflammation0.92859098
88MP0003868_abnormal_feces_composition0.91975789
89MP0004510_myositis0.90750693
90MP0002006_tumorigenesis0.89468213
91MP0002138_abnormal_hepatobiliary_system0.85772322
92MP0002234_abnormal_pharynx_morphology0.85265461
93MP0005174_abnormal_tail_pigmentation0.84370772
94MP0003953_abnormal_hormone_level0.82354892
95MP0001853_heart_inflammation0.82180283
96MP0009764_decreased_sensitivity_to0.81163669
97MP0005166_decreased_susceptibility_to0.80525483
98MP0002277_abnormal_respiratory_mucosa0.80271096
99MP0001533_abnormal_skeleton_physiology0.79377236
100MP0000477_abnormal_intestine_morphology0.78186258
101MP0003724_increased_susceptibility_to0.75105136
102MP0000613_abnormal_salivary_gland0.73789109
103MP0000015_abnormal_ear_pigmentation0.72909983
104MP0003795_abnormal_bone_structure0.72419216
105MP0009840_abnormal_foam_cell0.71981951
106MP0000470_abnormal_stomach_morphology0.71824381
107MP0005381_digestive/alimentary_phenotyp0.71175617
108MP0003693_abnormal_embryo_hatching0.70950831
109MP0002896_abnormal_bone_mineralization0.70844342
110MP0001270_distended_abdomen0.70384329
111MP0010307_abnormal_tumor_latency0.69296182
112MP0005375_adipose_tissue_phenotype0.66601222
113MP0008469_abnormal_protein_level0.66547840
114MP0001663_abnormal_digestive_system0.66525384
115MP0003787_abnormal_imprinting0.66096615
116MP0004185_abnormal_adipocyte_glucose0.65820174
117MP0003656_abnormal_erythrocyte_physiolo0.65533341
118MP0004883_abnormal_blood_vessel0.64910399
119MP0009763_increased_sensitivity_to0.64822666
120MP0001849_ear_inflammation0.64575470
121MP0003943_abnormal_hepatobiliary_system0.64152481
122MP0001879_abnormal_lymphatic_vessel0.63232282
123MP0003959_abnormal_lean_body0.62774320
124MP0002019_abnormal_tumor_incidence0.62692652
125MP0002837_dystrophic_cardiac_calcinosis0.61773537
126MP0003075_altered_response_to0.60215685
127MP0008874_decreased_physiological_sensi0.58841795
128MP0000609_abnormal_liver_physiology0.56141792
129MP0009931_abnormal_skin_appearance0.55834876
130MP0005390_skeleton_phenotype0.55814691
131MP0009115_abnormal_fat_cell0.54173493
132MP0009765_abnormal_xenobiotic_induced0.53390273
133MP0005083_abnormal_biliary_tract0.52862029
134MP0005409_darkened_coat_color0.52690067
135MP0005666_abnormal_adipose_tissue0.52010553

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)5.40527642
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.09633573
3Hypoglycemic seizures (HP:0002173)4.95335669
4Symptomatic seizures (HP:0011145)4.48404484
5Abnormal delayed hypersensitivity skin test (HP:0002963)4.41068589
6Abnormality of macrophages (HP:0004311)4.37851057
7Hypoglycemic coma (HP:0001325)4.20029891
8Abnormality of the pancreatic islet cells (HP:0006476)4.08166962
9Abnormality of endocrine pancreas physiology (HP:0012093)4.08166962
10Prolonged bleeding time (HP:0003010)4.07997725
11Myositis (HP:0100614)3.98223199
12Obstructive lung disease (HP:0006536)3.79318493
13Chronic obstructive pulmonary disease (HP:0006510)3.79318493
14Insulin-resistant diabetes mellitus (HP:0000831)3.77532999
15Pancreatic islet-cell hyperplasia (HP:0004510)3.77501493
16Elevated erythrocyte sedimentation rate (HP:0003565)3.68877876
17Recurrent bronchitis (HP:0002837)3.61892222
18Stomatitis (HP:0010280)3.59103967
19Agammaglobulinemia (HP:0004432)3.54886217
20Mediastinal lymphadenopathy (HP:0100721)3.51301506
21Large for gestational age (HP:0001520)3.51126726
22IgM deficiency (HP:0002850)3.46776605
23Encephalitis (HP:0002383)3.42193572
24Urinary glycosaminoglycan excretion (HP:0003541)3.40666337
25Mucopolysacchariduria (HP:0008155)3.40666337
26Recurrent gram-negative bacterial infections (HP:0005420)3.38264699
27Recurrent skin infections (HP:0001581)3.36975688
28Recurrent viral infections (HP:0004429)3.35464054
29Gastrointestinal infarctions (HP:0005244)3.27407251
30Decreased circulating renin level (HP:0003351)3.27307423
31Pustule (HP:0200039)3.24192524
32Orchitis (HP:0100796)3.24184418
33Gastrointestinal inflammation (HP:0004386)3.24147693
34Inflammation of the large intestine (HP:0002037)3.22186793
35Dysostosis multiplex (HP:0000943)3.20316146
36Chronic otitis media (HP:0000389)3.14049997
37Abnormality of polysaccharide metabolism (HP:0011012)3.12235873
38Abnormality of glycosaminoglycan metabolism (HP:0004371)3.12235873
39Abnormality of mucopolysaccharide metabolism (HP:0011020)3.12235873
40Colitis (HP:0002583)3.12042503
41Hyperglycemia (HP:0003074)3.11571940
42Late onset (HP:0003584)3.09675603
43Abnormality of T cell physiology (HP:0011840)3.09405498
44Petechiae (HP:0000967)3.06567511
45Cellulitis (HP:0100658)3.04368428
46T lymphocytopenia (HP:0005403)3.03632159
47Papilledema (HP:0001085)3.03521079
48Epistaxis (HP:0000421)3.03217959
49Retrobulbar optic neuritis (HP:0100654)2.98355918
50Optic neuritis (HP:0100653)2.98355918
51Abnormality of T cells (HP:0002843)2.93513436
52Granulocytopenia (HP:0001913)2.91140183
53Abnormality of calcium-phosphate metabolism (HP:0100530)2.87576416
54Abnormality of the fingertips (HP:0001211)2.86731834
55Gingivitis (HP:0000230)2.86508931
56Abnormal pancreas size (HP:0012094)2.84313636
57Abnormality of T cell number (HP:0011839)2.83253742
58Panhypogammaglobulinemia (HP:0003139)2.78284577
59Bronchitis (HP:0012387)2.76501371
60Verrucae (HP:0200043)2.75754088
61Papilloma (HP:0012740)2.75754088
62Hypochromic anemia (HP:0001931)2.73619170
63Urticaria (HP:0001025)2.73482100
64Ketoacidosis (HP:0001993)2.67634819
65Thoracolumbar scoliosis (HP:0002944)2.67239557
66Recurrent fungal infections (HP:0002841)2.65726606
67Insulin resistance (HP:0000855)2.63425810
68Meningitis (HP:0001287)2.63292482
69Gingival bleeding (HP:0000225)2.57403435
70Villous atrophy (HP:0011473)2.56418447
71Abnormality of small intestinal villus morphology (HP:0011472)2.56418447
72Abnormality of B cell number (HP:0010975)2.56087640
73B lymphocytopenia (HP:0010976)2.56087640
74Interstitial pulmonary disease (HP:0006530)2.54366388
75Eczematoid dermatitis (HP:0000976)2.52715574
76Gastrointestinal stroma tumor (HP:0100723)2.52266915
77Hypochromic microcytic anemia (HP:0004840)2.51969487
78Nasal polyposis (HP:0100582)2.50559040
79Leukocytosis (HP:0001974)2.47846718
80Prominent metopic ridge (HP:0005487)2.44614138
81Autoimmune hemolytic anemia (HP:0001890)2.42066522
82Purpura (HP:0000979)2.38767632
83Chronic sinusitis (HP:0011109)2.38289683
84Viral hepatitis (HP:0006562)2.37731030
85Abnormality of renin-angiotensin system (HP:0000847)2.34728961
86Lymphopenia (HP:0001888)2.34630621
87Abnormality of the nasal mucosa (HP:0000433)2.34147096
88Keratoconjunctivitis sicca (HP:0001097)2.32825522
89Increased IgM level (HP:0003496)2.32571447
90Hypokalemia (HP:0002900)2.31224648
91Limb hypertonia (HP:0002509)2.31013606
92Severe combined immunodeficiency (HP:0004430)2.28999983
93Pulmonary infiltrates (HP:0002113)2.28580289
94Hemoptysis (HP:0002105)2.26580159
95Abnormality of cells of the lymphoid lineage (HP:0012140)2.26367982
96Hyperactive renin-angiotensin system (HP:0000841)2.26250141
97Severe short stature (HP:0003510)2.22860632
98Hypergammaglobulinemia (HP:0010702)2.21480012
99Hyperparathyroidism (HP:0000843)2.19099203
100Macroorchidism (HP:0000053)2.18961391
101Abnormal platelet volume (HP:0011876)2.18299703
102Thrombocytosis (HP:0001894)2.17894368
103Slow saccadic eye movements (HP:0000514)2.17761821
104Recurrent abscess formation (HP:0002722)2.17035071
105Spontaneous hematomas (HP:0007420)2.16151839
106Thyroiditis (HP:0100646)2.16137543
107Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14773626
108Microcytic anemia (HP:0001935)2.14715298
109Pulmonary embolism (HP:0002204)2.14332442
110Arterial thrombosis (HP:0004420)2.14019075
111Eosinophilia (HP:0001880)2.12227505
112Episodic fever (HP:0001954)2.11812614
113Keratoconjunctivitis (HP:0001096)2.09433396
114Recurrent sinusitis (HP:0011108)2.06897992
115Skin ulcer (HP:0200042)2.05745707
116Hypoplasia of the thymus (HP:0000778)2.05296712
117Increased IgE level (HP:0003212)2.00045786
118Emphysema (HP:0002097)1.99153134
119Chronic diarrhea (HP:0002028)1.98688986
12011 pairs of ribs (HP:0000878)1.98403236
121Lymphoma (HP:0002665)1.97117248
122Abnormality of the metopic suture (HP:0005556)1.96436115
123IgA deficiency (HP:0002720)1.95993195
124Recurrent cutaneous fungal infections (HP:0011370)1.95466502
125Chronic mucocutaneous candidiasis (HP:0002728)1.95466502
126Unilateral renal agenesis (HP:0000122)1.94714523
127Recurrent bacterial skin infections (HP:0005406)1.94520963
128Sepsis (HP:0100806)1.92421256
129Abdominal distention (HP:0003270)1.92053960
130Seborrheic dermatitis (HP:0001051)1.91292715
131Aplasia/Hypoplasia of the thymus (HP:0010515)1.90142987
132Malnutrition (HP:0004395)1.89764045
133Recurrent lower respiratory tract infections (HP:0002783)1.88474154
134Recurrent pneumonia (HP:0006532)1.88459426
135Restrictive lung disease (HP:0002091)1.87743948
136Combined immunodeficiency (HP:0005387)1.87173288
137Skin rash (HP:0000988)1.87056549
138Irregular vertebral endplates (HP:0003301)1.86673815
139Hypercortisolism (HP:0001578)1.85826930
140Osteomyelitis (HP:0002754)1.85679842
141Increased cerebral lipofuscin (HP:0011813)1.84921270
142Exocrine pancreatic insufficiency (HP:0001738)1.84269850
143Abnormality of the pleura (HP:0002103)1.82371312
144Impaired platelet aggregation (HP:0003540)1.81853074
145Abnormal platelet function (HP:0011869)1.81853074
146Progressive neurologic deterioration (HP:0002344)1.81689467
147Thin bony cortex (HP:0002753)1.78641549
148Abnormality of potassium homeostasis (HP:0011042)1.77215790
149Generalized aminoaciduria (HP:0002909)1.76135455
150Vasculitis (HP:0002633)1.75922305
151Missing ribs (HP:0000921)1.73821310
152Autoimmune thrombocytopenia (HP:0001973)1.71949013
153Vacuolated lymphocytes (HP:0001922)1.71669894
154Chest pain (HP:0100749)1.70739227
155Hyperkalemia (HP:0002153)1.70182523

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK4.39882666
2INSRR4.18415131
3MAP4K14.01790167
4PRPF4B3.38355081
5TAOK33.31598385
6ERN13.21080756
7MAP3K102.83447986
8HIPK22.70393889
9TRIB32.62147346
10EEF2K2.56475250
11TNK22.33037354
12MAPK151.99293524
13BTK1.97759706
14FLT31.93687617
15SMG11.91227173
16JAK31.87730395
17ITK1.83046435
18ZAP701.79784430
19GRK61.75449093
20PTK61.69113640
21FRK1.58630462
22PKN21.53666753
23TYK21.51506807
24SIK31.51342457
25SCYL21.48942704
26SYK1.47881218
27JAK11.46377186
28IRAK31.42753168
29MAP3K21.42729134
30STK101.41512352
31PRKCH1.41404119
32MAP3K11.32845171
33EPHB11.28501354
34LRRK21.23594999
35FGFR41.22760342
36TEC1.21600062
37IRAK41.19645320
38CSK1.16626547
39MAP3K111.15269644
40FGFR31.12729263
41CDK121.08227243
42PRKD21.03981553
43JAK20.98834768
44EPHA30.97480536
45TESK20.95671726
46PDGFRA0.94984664
47SIK10.92427526
48ALK0.91965997
49BLK0.89437225
50LCK0.88939667
51DYRK1B0.87303157
52CDC42BPA0.85858200
53HCK0.84153901
54TXK0.83208681
55FES0.82899950
56SIK20.81287157
57MAPK120.78598522
58FGR0.78238283
59MARK30.78219695
60CSF1R0.77956509
61CAMKK20.75640624
62KSR20.75495845
63CDK40.75346865
64MATK0.74988420
65RIPK10.74335946
66PDPK10.74045592
67TBK10.73896085
68TAOK20.72667502
69NLK0.72530500
70BRSK20.70438260
71RIPK40.70204165
72CAMKK10.69792690
73BRD40.69684033
74LYN0.68471571
75BMPR20.67651841
76KIT0.66994225
77IKBKE0.66412789
78ICK0.65866949
79PTK20.65621183
80CHUK0.63728045
81MAP2K20.62739694
82YES10.62537065
83PRKD30.62424695
84EIF2AK30.62155825
85UHMK10.62116311
86MAP2K30.61231820
87IRAK20.58462969
88MAPK70.57443743
89MARK20.53716718
90FYN0.53032386
91RET0.52504350
92MAP3K140.51988671
93PDGFRB0.50803249
94PIM10.50395582
95RPS6KC10.50121976
96RPS6KL10.50121976
97TGFBR20.46861465
98MAP3K130.45380595
99IRAK10.44849632
100PRKD10.44645607
101CDK60.43935733
102RPS6KA20.43881893
103WNK40.42528500
104MAP3K70.42011127
105PDK10.41614701
106BMX0.41583927
107PRKCQ0.40671885
108WNK10.40297006
109RPS6KA40.39787784
110MAP3K60.39123057
111RPS6KA60.38844644
112TESK10.38243004
113NEK20.38182299
114MTOR0.36345392
115CDK90.35520452
116MAPKAPK30.35499676
117MAPK110.34848895
118SGK30.33881702
119MAP3K30.33792181
120CLK10.33524468
121MAP2K60.33480010
122RPS6KB20.32974643
123TAOK10.32380172
124MAPKAPK20.31903615
125CAMK1G0.31047085
126IKBKB0.30333819
127MAPK40.30024012
128STK110.29790073
129MAPK30.28799261
130PIK3CG0.28107955

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.77187558
2Primary immunodeficiency_Homo sapiens_hsa053402.87639698
3Protein export_Homo sapiens_hsa030602.83286300
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.56509191
5Allograft rejection_Homo sapiens_hsa053302.47052368
6Graft-versus-host disease_Homo sapiens_hsa053322.41934448
7Type II diabetes mellitus_Homo sapiens_hsa049302.37908793
8Autoimmune thyroid disease_Homo sapiens_hsa053202.34030061
9Carbohydrate digestion and absorption_Homo sapiens_hsa049732.29371322
10B cell receptor signaling pathway_Homo sapiens_hsa046622.26660215
11Insulin secretion_Homo sapiens_hsa049112.06730090
12Staphylococcus aureus infection_Homo sapiens_hsa051501.98137146
13Type I diabetes mellitus_Homo sapiens_hsa049401.78925256
14Antigen processing and presentation_Homo sapiens_hsa046121.75063368
15Asthma_Homo sapiens_hsa053101.73265261
16Sulfur metabolism_Homo sapiens_hsa009201.70993189
17N-Glycan biosynthesis_Homo sapiens_hsa005101.53921216
18Viral myocarditis_Homo sapiens_hsa054161.50257821
19Other glycan degradation_Homo sapiens_hsa005111.40310096
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37700276
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.37525230
22T cell receptor signaling pathway_Homo sapiens_hsa046601.36022578
23Insulin resistance_Homo sapiens_hsa049311.34393187
24Osteoclast differentiation_Homo sapiens_hsa043801.30609423
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.29535779
26Hematopoietic cell lineage_Homo sapiens_hsa046401.28577665
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27876076
28Leishmaniasis_Homo sapiens_hsa051401.23823507
29Lysosome_Homo sapiens_hsa041421.22716232
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22453788
31Prolactin signaling pathway_Homo sapiens_hsa049171.21440476
32Chronic myeloid leukemia_Homo sapiens_hsa052201.18272136
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13875274
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12749995
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10319591
36Acute myeloid leukemia_Homo sapiens_hsa052211.10234375
37Malaria_Homo sapiens_hsa051441.07488703
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.07058160
39Chemokine signaling pathway_Homo sapiens_hsa040621.05187395
40Notch signaling pathway_Homo sapiens_hsa043301.05009851
41Selenocompound metabolism_Homo sapiens_hsa004501.03915973
42Platelet activation_Homo sapiens_hsa046111.01654820
43Measles_Homo sapiens_hsa051621.01344190
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98337974
45ABC transporters_Homo sapiens_hsa020100.97839580
46Leukocyte transendothelial migration_Homo sapiens_hsa046700.95386650
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.95067637
48* Pancreatic secretion_Homo sapiens_hsa049720.91532988
49mTOR signaling pathway_Homo sapiens_hsa041500.89066895
50Toxoplasmosis_Homo sapiens_hsa051450.89030295
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.88912430
52Choline metabolism in cancer_Homo sapiens_hsa052310.87893758
53Inositol phosphate metabolism_Homo sapiens_hsa005620.85371364
54Non-small cell lung cancer_Homo sapiens_hsa052230.84606953
55Vibrio cholerae infection_Homo sapiens_hsa051100.82981832
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.81688986
57Pancreatic cancer_Homo sapiens_hsa052120.81246806
58Thyroid hormone synthesis_Homo sapiens_hsa049180.79745440
59African trypanosomiasis_Homo sapiens_hsa051430.79189423
60Cocaine addiction_Homo sapiens_hsa050300.78828233
61Hepatitis B_Homo sapiens_hsa051610.76835452
62Glucagon signaling pathway_Homo sapiens_hsa049220.75329492
63Phagosome_Homo sapiens_hsa041450.74587940
64Estrogen signaling pathway_Homo sapiens_hsa049150.74400751
65Lysine degradation_Homo sapiens_hsa003100.72632872
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71832373
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70480259
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69284625
69VEGF signaling pathway_Homo sapiens_hsa043700.68861897
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.68404484
71Rheumatoid arthritis_Homo sapiens_hsa053230.68276149
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66748669
73GnRH signaling pathway_Homo sapiens_hsa049120.66416422
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65582737
75Tuberculosis_Homo sapiens_hsa051520.65040508
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64945020
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63524791
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63194020
79Viral carcinogenesis_Homo sapiens_hsa052030.63058622
80Herpes simplex infection_Homo sapiens_hsa051680.62274393
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61059361
82Influenza A_Homo sapiens_hsa051640.61024899
83Legionellosis_Homo sapiens_hsa051340.60993715
84Apoptosis_Homo sapiens_hsa042100.60891817
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.60682587
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59837462
87Long-term potentiation_Homo sapiens_hsa047200.59214062
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58656246
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58647322
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58161511
91Insulin signaling pathway_Homo sapiens_hsa049100.57988446
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55839615
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55468505
94Taste transduction_Homo sapiens_hsa047420.54898941
95FoxO signaling pathway_Homo sapiens_hsa040680.54816867
96Endometrial cancer_Homo sapiens_hsa052130.52843223
97Prostate cancer_Homo sapiens_hsa052150.52813972
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.52691401
99ErbB signaling pathway_Homo sapiens_hsa040120.51451294
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50693403
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50361867
102Dorso-ventral axis formation_Homo sapiens_hsa043200.50063825
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49977651
104TNF signaling pathway_Homo sapiens_hsa046680.49201110
105Thyroid cancer_Homo sapiens_hsa052160.49196340
106HTLV-I infection_Homo sapiens_hsa051660.48933782
107Renal cell carcinoma_Homo sapiens_hsa052110.47622162
108Salmonella infection_Homo sapiens_hsa051320.46046002
109Endocytosis_Homo sapiens_hsa041440.45888423
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45671618
111HIF-1 signaling pathway_Homo sapiens_hsa040660.45203506
112Shigellosis_Homo sapiens_hsa051310.44793836
113Hepatitis C_Homo sapiens_hsa051600.44673348
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43311258
115* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42676695
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42414744
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41657635
118Epstein-Barr virus infection_Homo sapiens_hsa051690.40365860
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39957553
120Non-homologous end-joining_Homo sapiens_hsa034500.39146862
121Colorectal cancer_Homo sapiens_hsa052100.38962044
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38476692
123Pertussis_Homo sapiens_hsa051330.38309944
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37615216
125Cholinergic synapse_Homo sapiens_hsa047250.37426995
126Glioma_Homo sapiens_hsa052140.37174709
127MAPK signaling pathway_Homo sapiens_hsa040100.37100365

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