ATP2B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ionotropic glutamate receptor signaling pathway (GO:0035235)5.85871951
2glutamate receptor signaling pathway (GO:0007215)5.63570688
3vocalization behavior (GO:0071625)5.32454890
4protein localization to synapse (GO:0035418)5.04439163
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.93878836
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.86560836
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.85661923
8neuron cell-cell adhesion (GO:0007158)4.73042220
9gamma-aminobutyric acid signaling pathway (GO:0007214)4.68826010
10synaptic transmission, glutamatergic (GO:0035249)4.56537326
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.55664548
12neuron-neuron synaptic transmission (GO:0007270)4.49437812
13regulation of glutamate receptor signaling pathway (GO:1900449)4.47568064
14synaptic vesicle exocytosis (GO:0016079)4.47082286
15neuron recognition (GO:0008038)4.42938006
16regulation of long-term neuronal synaptic plasticity (GO:0048169)4.40050861
17G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.33170786
18locomotory exploration behavior (GO:0035641)4.25106360
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.23821588
20regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)4.20418744
21regulation of dendritic spine morphogenesis (GO:0061001)4.16263697
22neuronal action potential propagation (GO:0019227)4.14740811
23exploration behavior (GO:0035640)4.14680904
24regulation of excitatory postsynaptic membrane potential (GO:0060079)4.13631184
25positive regulation of synapse maturation (GO:0090129)4.13416503
26behavioral fear response (GO:0001662)4.03375058
27behavioral defense response (GO:0002209)4.03375058
28axonal fasciculation (GO:0007413)3.98745348
29regulation of neuronal synaptic plasticity (GO:0048168)3.97430535
30response to histamine (GO:0034776)3.97398406
31long-term synaptic potentiation (GO:0060291)3.95654112
32regulation of postsynaptic membrane potential (GO:0060078)3.92034269
33G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.89660031
34regulation of synaptic vesicle exocytosis (GO:2000300)3.89129430
35L-amino acid import (GO:0043092)3.85617450
36long-term memory (GO:0007616)3.81591246
37positive regulation of dendritic spine morphogenesis (GO:0061003)3.81289721
38regulation of synaptic plasticity (GO:0048167)3.80308344
39glutamate secretion (GO:0014047)3.79686913
40fear response (GO:0042596)3.79164651
41long term synaptic depression (GO:0060292)3.75012302
42sodium ion export (GO:0071436)3.74691122
43negative regulation of dendrite morphogenesis (GO:0050774)3.69109653
44regulation of synaptic vesicle transport (GO:1902803)3.67511782
45synaptic vesicle endocytosis (GO:0048488)3.65338315
46transmission of nerve impulse (GO:0019226)3.62868518
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.62803695
48dendritic spine organization (GO:0097061)3.61674944
49cellular potassium ion homeostasis (GO:0030007)3.61515726
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.61028643
51innervation (GO:0060384)3.59888913
52positive regulation of neurotransmitter secretion (GO:0001956)3.56733689
53regulation of dendritic spine development (GO:0060998)3.56584667
54dendritic spine morphogenesis (GO:0060997)3.50813748
55neurotransmitter-gated ion channel clustering (GO:0072578)3.50029367
56presynaptic membrane assembly (GO:0097105)3.47748029
57regulation of ARF protein signal transduction (GO:0032012)3.47502383
58synaptic vesicle maturation (GO:0016188)3.46805501
59regulation of synapse structural plasticity (GO:0051823)3.46566987
60synaptic vesicle docking involved in exocytosis (GO:0016081)3.45568331
61regulation of glutamate secretion (GO:0014048)3.44725984
62regulation of vesicle fusion (GO:0031338)3.42679056
63behavioral response to cocaine (GO:0048148)3.42093778
64positive regulation of dendritic spine development (GO:0060999)3.39062039
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.37189537
66regulation of Rac protein signal transduction (GO:0035020)3.35866220
67learning (GO:0007612)3.34761815
68cochlea development (GO:0090102)3.34391485
69synaptic transmission, dopaminergic (GO:0001963)3.32684542
70positive regulation of membrane potential (GO:0045838)3.32359374
71regulation of female receptivity (GO:0045924)3.29780642
72chemosensory behavior (GO:0007635)3.27351605
73phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.23750657
74membrane depolarization (GO:0051899)3.23192842
75glycosphingolipid biosynthetic process (GO:0006688)3.22973474
76amino acid import (GO:0043090)3.21800493
77inner ear receptor cell development (GO:0060119)3.21677878
78postsynaptic membrane organization (GO:0001941)3.21256020
79neurotransmitter secretion (GO:0007269)3.20458565
80presynaptic membrane organization (GO:0097090)3.19471749
81regulation of neurotransmitter secretion (GO:0046928)3.19409757
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18793104
83response to amphetamine (GO:0001975)3.18481591
84cerebellar Purkinje cell differentiation (GO:0021702)3.18138482
85regulation of axon regeneration (GO:0048679)3.17943037
86regulation of neuron projection regeneration (GO:0070570)3.17943037
87regulation of synapse maturation (GO:0090128)3.16595222
88startle response (GO:0001964)3.15184492
89cytoskeletal anchoring at plasma membrane (GO:0007016)3.14370298
90layer formation in cerebral cortex (GO:0021819)3.12323813
91positive regulation of neurotransmitter transport (GO:0051590)3.11885271
92nerve growth factor signaling pathway (GO:0038180)3.11156809
93striatum development (GO:0021756)3.10760317
94female mating behavior (GO:0060180)3.10154346
95cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.07702555
96positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07540612
97membrane depolarization during action potential (GO:0086010)3.06869176
98ephrin receptor signaling pathway (GO:0048013)3.06693647
99vesicle transport along microtubule (GO:0047496)3.06376732
100serotonin metabolic process (GO:0042428)3.05064747
101cerebellar granule cell differentiation (GO:0021707)3.04630494
102positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.01538222
103neurotransmitter transport (GO:0006836)2.98321061
104neuron remodeling (GO:0016322)2.97494419
105positive regulation of vesicle fusion (GO:0031340)2.94137452
106negative regulation of amino acid transport (GO:0051956)2.93193934
107synaptic transmission (GO:0007268)2.88952198
108regulation of synaptic transmission (GO:0050804)2.88868619
109detection of calcium ion (GO:0005513)2.88531545
110negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.87790360
111negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.86687107
112negative regulation of cell killing (GO:0031342)2.86687107
113regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.82732845
114regulation of voltage-gated calcium channel activity (GO:1901385)2.80031930
115cellular response to ethanol (GO:0071361)2.75653702
116potassium ion import (GO:0010107)2.75007575
117regulation of neurotransmitter transport (GO:0051588)2.73838323
118neuromuscular process controlling balance (GO:0050885)2.72927738
119proline transport (GO:0015824)2.72131004
120positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.71948031
121membrane assembly (GO:0071709)2.68426384
122positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.67476023
123lipid translocation (GO:0034204)2.61365237
124phospholipid translocation (GO:0045332)2.61365237
125clathrin coat assembly (GO:0048268)2.58677028
126neuromuscular synaptic transmission (GO:0007274)2.58195639
127negative regulation of dendrite development (GO:2000171)2.49871255
128regulation of clathrin-mediated endocytosis (GO:2000369)2.49032462
129regulation of cell communication by electrical coupling (GO:0010649)2.48323887
130vesicle docking (GO:0048278)2.46725621
131neutrophil mediated immunity (GO:0002446)2.44284089
132regulation of neurotransmitter levels (GO:0001505)2.43712621
133synaptic vesicle transport (GO:0048489)2.41775817
134establishment of synaptic vesicle localization (GO:0097480)2.41775817
135positive regulation of heat generation (GO:0031652)2.41271560
136dendrite morphogenesis (GO:0048813)2.40551666
137neuromuscular process (GO:0050905)2.39944190
138potassium ion homeostasis (GO:0055075)2.39570387
139central nervous system projection neuron axonogenesis (GO:0021952)2.38345201
140regulation of fever generation (GO:0031620)2.37927135
141positive regulation of macrophage cytokine production (GO:0060907)2.37874279
142protein localization to endosome (GO:0036010)2.37357580
143acidic amino acid transport (GO:0015800)2.37159903
144regulation of exocytosis (GO:0017157)2.36323255
145regulation of Rap GTPase activity (GO:0032317)2.36270229

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.18929179
2GBX2_23144817_ChIP-Seq_PC3_Human4.21297954
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10147050
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09649633
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00944424
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.75378650
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56537066
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56537066
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51231901
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49511075
11REST_21632747_ChIP-Seq_MESCs_Mouse2.47498433
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45592747
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39026115
14* RARB_27405468_Chip-Seq_BRAIN_Mouse2.38381496
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.38263572
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32273818
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.29449057
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.22324879
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17323355
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13574634
21DROSHA_22980978_ChIP-Seq_HELA_Human2.13336010
22TAF15_26573619_Chip-Seq_HEK293_Human2.12160493
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.07881867
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01746686
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.99785931
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99002963
27* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88044161
28* SMAD4_21799915_ChIP-Seq_A2780_Human1.87755050
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86297231
30AR_21572438_ChIP-Seq_LNCaP_Human1.84022991
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83048821
32P300_19829295_ChIP-Seq_ESCs_Human1.81425205
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.81325052
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76201157
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75634997
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72686045
37FUS_26573619_Chip-Seq_HEK293_Human1.68477502
38* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68050403
39ZNF274_21170338_ChIP-Seq_K562_Hela1.64724869
40* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.63388066
41* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62399154
42VDR_22108803_ChIP-Seq_LS180_Human1.61974489
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.60040473
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.59966245
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.57360172
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.57360172
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.54744108
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.52767968
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47923998
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.47092141
51* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.45859889
52AR_25329375_ChIP-Seq_VCAP_Human1.44989500
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44614232
54TP53_16413492_ChIP-PET_HCT116_Human1.44162957
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43440519
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43163562
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42549109
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41054788
59* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40355909
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39270773
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38859656
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37648656
63CTNNB1_20460455_ChIP-Seq_HCT116_Human1.37635303
64IGF1R_20145208_ChIP-Seq_DFB_Human1.36976614
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36106589
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.35880103
67STAT3_23295773_ChIP-Seq_U87_Human1.34080010
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33954894
69* PIAS1_25552417_ChIP-Seq_VCAP_Human1.32999408
70TP53_18474530_ChIP-ChIP_U2OS_Human1.32399089
71* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31725861
72* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.31658404
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.29414816
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28573567
75CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.28559471
76* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28218773
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.27849690
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.27374951
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27213988
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26375723
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26343755
82EGR1_19374776_ChIP-ChIP_THP-1_Human1.25074345
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24376088
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24006984
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23235190
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23065118
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.22032899
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.21243757
89TCF4_23295773_ChIP-Seq_U87_Human1.19459590
90* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18950522
91BCAT_22108803_ChIP-Seq_LS180_Human1.16750197
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16104165
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.15632438
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15578753
95RUNX2_22187159_ChIP-Seq_PCA_Human1.14978628
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14761438
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13685500
98JUN_21703547_ChIP-Seq_K562_Human1.13406685
99* AR_19668381_ChIP-Seq_PC3_Human1.13298094
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.12549403
101* FLI1_21867929_ChIP-Seq_TH2_Mouse1.11406998
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10730466
103AHR_22903824_ChIP-Seq_MCF-7_Human1.09720874
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09422376
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09310275
106ERG_21242973_ChIP-ChIP_JURKAT_Human1.08366265
107* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07133732
108SMAD3_21741376_ChIP-Seq_HESCs_Human1.06646261
109* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06622835
110YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06376225
111BRD4_25478319_ChIP-Seq_HGPS_Human1.06331248
112* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06154534
113RNF2_27304074_Chip-Seq_NSC_Mouse1.04485001
114WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03435209
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02695059
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02525195
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01885481
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01587276
119P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01587040
120RING1B_27294783_Chip-Seq_NPCs_Mouse1.01206499
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99826450
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99826450
123E2F1_18555785_Chip-Seq_ESCs_Mouse0.97565290
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96631057
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96084734
126ER_23166858_ChIP-Seq_MCF-7_Human0.95717763
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95015780
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94271479
129* KDM2B_26808549_Chip-Seq_REH_Human0.93589757
130P53_22387025_ChIP-Seq_ESCs_Mouse0.92298249

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.58209482
2MP0003880_abnormal_central_pattern6.25409594
3MP0000569_abnormal_digit_pigmentation4.25253482
4MP0003635_abnormal_synaptic_transmissio4.21686133
5MP0004270_analgesia3.86268877
6MP0009745_abnormal_behavioral_response3.61998331
7MP0002063_abnormal_learning/memory/cond3.59737468
8MP0001968_abnormal_touch/_nociception3.14241812
9MP0002064_seizures3.00426080
10MP0002822_catalepsy2.95352813
11MP0002572_abnormal_emotion/affect_behav2.93897052
12MP0001501_abnormal_sleep_pattern2.87818745
13MP0002736_abnormal_nociception_after2.86690176
14MP0002272_abnormal_nervous_system2.60882584
15MP0002735_abnormal_chemical_nociception2.40543964
16MP0001440_abnormal_grooming_behavior2.39795431
17MP0001486_abnormal_startle_reflex2.37123091
18MP0009046_muscle_twitch2.34726552
19MP0002734_abnormal_mechanical_nocicepti2.20832266
20MP0003329_amyloid_beta_deposits2.14090423
21MP0001188_hyperpigmentation2.10414711
22MP0002067_abnormal_sensory_capabilities1.91224640
23MP0000778_abnormal_nervous_system1.84280646
24MP0002733_abnormal_thermal_nociception1.84124951
25MP0003690_abnormal_glial_cell1.81011711
26MP0002184_abnormal_innervation1.80437472
27MP0001529_abnormal_vocalization1.80057584
28MP0010352_gastrointestinal_tract_polyps1.78507315
29MP0003123_paternal_imprinting1.76774166
30MP0009780_abnormal_chondrocyte_physiolo1.73631836
31MP0001970_abnormal_pain_threshold1.73507018
32MP0003303_peritoneal_inflammation1.71067303
33MP0005423_abnormal_somatic_nervous1.69751334
34MP0003787_abnormal_imprinting1.68182783
35MP0006276_abnormal_autonomic_nervous1.65220012
36MP0002909_abnormal_adrenal_gland1.60597059
37MP0002557_abnormal_social/conspecific_i1.57955938
38MP0008057_abnormal_DNA_replication1.56988578
39MP0002837_dystrophic_cardiac_calcinosis1.55384350
40MP0001348_abnormal_lacrimal_gland1.55014453
41MP0004924_abnormal_behavior1.54058310
42MP0005386_behavior/neurological_phenoty1.54058310
43MP0003879_abnormal_hair_cell1.53051238
44MP0001299_abnormal_eye_distance/1.50885824
45MP0005409_darkened_coat_color1.49889104
46MP0003705_abnormal_hypodermis_morpholog1.49272083
47MP0004145_abnormal_muscle_electrophysio1.45862857
48MP0004811_abnormal_neuron_physiology1.38923072
49MP0004858_abnormal_nervous_system1.38912182
50MP0006054_spinal_hemorrhage1.38788848
51MP0001984_abnormal_olfaction1.35849882
52MP0010386_abnormal_urinary_bladder1.34744849
53MP0004510_myositis1.34522898
54MP0003172_abnormal_lysosome_physiology1.33839755
55MP0008877_abnormal_DNA_methylation1.32274315
56MP0003890_abnormal_embryonic-extraembry1.31868893
57MP0008569_lethality_at_weaning1.30532491
58MP0001502_abnormal_circadian_rhythm1.28867059
59MP0003091_abnormal_cell_migration1.28531974
60MP0000955_abnormal_spinal_cord1.28094253
61MP0002066_abnormal_motor_capabilities/c1.28063566
62MP0002882_abnormal_neuron_morphology1.26147410
63MP0003121_genomic_imprinting1.24053862
64MP0006292_abnormal_olfactory_placode1.22591193
65MP0003950_abnormal_plasma_membrane1.22308092
66MP0010678_abnormal_skin_adnexa1.21597207
67MP0005646_abnormal_pituitary_gland1.20993520
68MP0005248_abnormal_Harderian_gland1.20934133
69MP0003633_abnormal_nervous_system1.16477329
70MP0005551_abnormal_eye_electrophysiolog1.14048302
71MP0001905_abnormal_dopamine_level1.13681685
72MP0004484_altered_response_of1.12938940
73MP0000604_amyloidosis1.11916148
74MP0002332_abnormal_exercise_endurance1.08142897
75MP0003828_pulmonary_edema1.06397647
76MP0000383_abnormal_hair_follicle1.06364415
77MP0005645_abnormal_hypothalamus_physiol1.00142679
78MP0004885_abnormal_endolymph1.00119069
79MP0003631_nervous_system_phenotype0.97599166
80MP0005166_decreased_susceptibility_to0.97393325
81MP0002152_abnormal_brain_morphology0.97143791
82MP0003045_fibrosis0.96239380
83MP0000751_myopathy0.95628265
84MP0002234_abnormal_pharynx_morphology0.95068978
85MP0005623_abnormal_meninges_morphology0.92975038
86MP0002876_abnormal_thyroid_physiology0.90796884
87MP0002069_abnormal_eating/drinking_beha0.90112465
88MP0004215_abnormal_myocardial_fiber0.89193088
89MP0005076_abnormal_cell_differentiation0.88839998
90MP0002229_neurodegeneration0.88409549
91MP0008874_decreased_physiological_sensi0.87782850
92MP0004142_abnormal_muscle_tone0.87201259
93MP0001963_abnormal_hearing_physiology0.86305048
94MP0004085_abnormal_heartbeat0.86282051
95MP0005535_abnormal_body_temperature0.85764023
96MP0002009_preneoplasia0.85262794
97MP0004742_abnormal_vestibular_system0.84766323
98MP0002133_abnormal_respiratory_system0.82387973
99MP0005388_respiratory_system_phenotype0.82387973
100MP0000427_abnormal_hair_cycle0.79132162
101MP0003183_abnormal_peptide_metabolism0.78331944
102MP0008872_abnormal_physiological_respon0.78240375
103MP0000733_abnormal_muscle_development0.77698051
104MP0001765_abnormal_ion_homeostasis0.77271143
105MP0000013_abnormal_adipose_tissue0.74985383
106MP0003075_altered_response_to0.74741400
107MP0010234_abnormal_vibrissa_follicle0.74717276
108MP0008004_abnormal_stomach_pH0.74649476
109MP0001664_abnormal_digestion0.72225564
110MP0002752_abnormal_somatic_nervous0.70101521
111MP0001485_abnormal_pinna_reflex0.70022268
112MP0005310_abnormal_salivary_gland0.69938293
113MP0009379_abnormal_foot_pigmentation0.69888075
114MP0002295_abnormal_pulmonary_circulatio0.69825619
115MP0001177_atelectasis0.68320841
116MP0005394_taste/olfaction_phenotype0.66602303
117MP0005499_abnormal_olfactory_system0.66602303
118MP0003221_abnormal_cardiomyocyte_apopto0.66223480
119MP0002896_abnormal_bone_mineralization0.66056012
120MP0000631_abnormal_neuroendocrine_gland0.65674636
121MP0002090_abnormal_vision0.65541544
122MP0005164_abnormal_response_to0.63561110
123MP0000026_abnormal_inner_ear0.61809577
124MP0002998_abnormal_bone_remodeling0.61675009
125MP0003632_abnormal_nervous_system0.61385990
126MP0003122_maternal_imprinting0.61184009
127MP0004233_abnormal_muscle_weight0.57964064
128MP0005187_abnormal_penis_morphology0.57885843
129MP0001346_abnormal_lacrimal_gland0.57689330
130MP0003634_abnormal_glial_cell0.57614391
131MP0005167_abnormal_blood-brain_barrier0.54858736
132MP0004883_abnormal_blood_vessel0.54443986
133MP0003283_abnormal_digestive_organ0.53230329
134MP0000015_abnormal_ear_pigmentation0.52417588
135MP0000920_abnormal_myelination0.51517709
136MP0006072_abnormal_retinal_apoptosis0.51284086
137MP0005171_absent_coat_pigmentation0.48957401
138MP0003137_abnormal_impulse_conducting0.46719426
139MP0003861_abnormal_nervous_system0.45220586
140MP0001943_abnormal_respiration0.44623113

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.83739008
2Focal seizures (HP:0007359)6.01503488
3Epileptic encephalopathy (HP:0200134)5.44521951
4Myokymia (HP:0002411)5.36977906
5Atonic seizures (HP:0010819)5.30515874
6Hyperventilation (HP:0002883)5.13810036
7Visual hallucinations (HP:0002367)5.06790903
8Absence seizures (HP:0002121)4.99866064
9Febrile seizures (HP:0002373)4.99458130
10Dialeptic seizures (HP:0011146)4.55571585
11Cerebral inclusion bodies (HP:0100314)4.17652212
12Generalized tonic-clonic seizures (HP:0002069)4.05249420
13Progressive cerebellar ataxia (HP:0002073)3.90252874
14Amblyopia (HP:0000646)3.90016014
15Broad-based gait (HP:0002136)3.83422355
16Neurofibrillary tangles (HP:0002185)3.66743845
17Excessive salivation (HP:0003781)3.55252282
18Drooling (HP:0002307)3.55252282
19Supranuclear gaze palsy (HP:0000605)3.54090397
20Papilledema (HP:0001085)3.26527616
21Dysmetria (HP:0001310)3.19593700
22Absent speech (HP:0001344)3.18526733
23Gaze-evoked nystagmus (HP:0000640)3.10274596
24Papillary thyroid carcinoma (HP:0002895)3.06049733
25Hydroureter (HP:0000072)3.05426782
26Diplopia (HP:0000651)3.04334837
27Abnormality of binocular vision (HP:0011514)3.04334837
28Truncal ataxia (HP:0002078)3.03265072
29Testicular atrophy (HP:0000029)3.01393124
30Dysdiadochokinesis (HP:0002075)3.00952136
31Epileptiform EEG discharges (HP:0011182)3.00939427
32Anxiety (HP:0000739)2.99058045
33Poor eye contact (HP:0000817)2.98532635
34Hemiparesis (HP:0001269)2.94542260
35Action tremor (HP:0002345)2.93134071
36Akinesia (HP:0002304)2.90030430
37Cystic hygroma (HP:0000476)2.75663267
38Impaired smooth pursuit (HP:0007772)2.74085866
39Lower limb muscle weakness (HP:0007340)2.73705833
40Thickened helices (HP:0000391)2.73506870
41Spastic gait (HP:0002064)2.71605061
42Impaired social interactions (HP:0000735)2.70483748
43Abnormal social behavior (HP:0012433)2.70483748
44Protruding tongue (HP:0010808)2.62397906
45Impaired vibration sensation in the lower limbs (HP:0002166)2.60536129
46Depression (HP:0000716)2.58795002
47EEG with generalized epileptiform discharges (HP:0011198)2.52845905
48Scanning speech (HP:0002168)2.51539908
49Genetic anticipation (HP:0003743)2.49723145
50Abnormality of salivation (HP:0100755)2.49561389
51Subacute progressive viral hepatitis (HP:0006572)2.48469796
52Apathy (HP:0000741)2.47403023
53Absent frontal sinuses (HP:0002688)2.46078742
54Stereotypic behavior (HP:0000733)2.41801044
55Popliteal pterygium (HP:0009756)2.40539440
56Termporal pattern (HP:0011008)2.39903749
57Insidious onset (HP:0003587)2.39903749
58Large earlobe (HP:0009748)2.39814885
59Disinhibition (HP:0000734)2.38762348
60Decreased circulating renin level (HP:0003351)2.36354439
61Ankle clonus (HP:0011448)2.33123014
62Urinary bladder sphincter dysfunction (HP:0002839)2.32311390
63Delusions (HP:0000746)2.31064271
64Retinal dysplasia (HP:0007973)2.26952985
65Status epilepticus (HP:0002133)2.24841957
66Diminished motivation (HP:0000745)2.24604371
67Progressive inability to walk (HP:0002505)2.24246996
68Inability to walk (HP:0002540)2.23610829
69Widely spaced teeth (HP:0000687)2.21633523
70Fair hair (HP:0002286)2.21037594
71Torticollis (HP:0000473)2.20398953
72Hypsarrhythmia (HP:0002521)2.19991436
73Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.17948905
74Degeneration of the lateral corticospinal tracts (HP:0002314)2.17948905
75Abnormality of the lower motor neuron (HP:0002366)2.17702187
76Type II lissencephaly (HP:0007260)2.15416336
77Generalized myoclonic seizures (HP:0002123)2.14578492
78Volvulus (HP:0002580)2.14547646
79Abnormality of ocular smooth pursuit (HP:0000617)2.12623119
80Tetraplegia (HP:0002445)2.12577049
81Mutism (HP:0002300)2.11768637
82Psychosis (HP:0000709)2.10246808
83Nuclear cataract (HP:0100018)2.10200233
84Oligodactyly (hands) (HP:0001180)2.08660216
85Bradykinesia (HP:0002067)2.07474721
86Obstructive sleep apnea (HP:0002870)2.07378407
87Slow saccadic eye movements (HP:0000514)2.06731246
88Overgrowth (HP:0001548)2.06157238
89Postural instability (HP:0002172)2.05557820
90Lower limb amyotrophy (HP:0007210)2.05099908
91Inappropriate behavior (HP:0000719)2.04503433
92Abnormal eating behavior (HP:0100738)2.03657611
93Agnosia (HP:0010524)2.03131776
94Global brain atrophy (HP:0002283)2.02658032
95Generalized hypopigmentation of hair (HP:0011358)2.01675374
96Choroideremia (HP:0001139)2.00878849
97Deep palmar crease (HP:0006191)2.00408871
98Blue irides (HP:0000635)1.99432315
99Lower limb asymmetry (HP:0100559)1.99411162
100Clonus (HP:0002169)1.99094441
101Dysmetric saccades (HP:0000641)1.98844497
102Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.96501324
103Limb dystonia (HP:0002451)1.94066652
104Fetal akinesia sequence (HP:0001989)1.93541069
105Exotropia (HP:0000577)1.93270682
106Arterial tortuosity (HP:0005116)1.92748109
107Curly hair (HP:0002212)1.90954309
108Cubitus valgus (HP:0002967)1.90862244
109Heterochromia iridis (HP:0001100)1.89886360
110Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.89591276
111Syncope (HP:0001279)1.88735411
112Rapidly progressive (HP:0003678)1.87534459
113Deeply set eye (HP:0000490)1.87387932
114Urinary urgency (HP:0000012)1.86882596
115Amyotrophic lateral sclerosis (HP:0007354)1.85754944
116Autism (HP:0000717)1.85381505
117Double outlet right ventricle (HP:0001719)1.83335660
118Congenital malformation of the right heart (HP:0011723)1.83335660
119Aqueductal stenosis (HP:0002410)1.83129558
120Impaired vibratory sensation (HP:0002495)1.82196803
121Gastroesophageal reflux (HP:0002020)1.81576450
122Vascular tortuosity (HP:0004948)1.81312232
123Neuronal loss in central nervous system (HP:0002529)1.79728305
124Thyroid carcinoma (HP:0002890)1.78723811
125Abnormality of the corticospinal tract (HP:0002492)1.78495752
126Incomplete penetrance (HP:0003829)1.78455656
127Absent/shortened dynein arms (HP:0200106)1.78094790
128Dynein arm defect of respiratory motile cilia (HP:0012255)1.78094790
129Spinal cord lesions (HP:0100561)1.76500533
130Syringomyelia (HP:0003396)1.76500533
131Gait ataxia (HP:0002066)1.75948995
132Pulmonic stenosis (HP:0001642)1.75449751
133Abnormality of the frontal sinuses (HP:0002687)1.74433713
134Distal lower limb amyotrophy (HP:0008944)1.74311854
135Clumsiness (HP:0002312)1.74291486
136Type 2 muscle fiber atrophy (HP:0003554)1.71896923
137Intention tremor (HP:0002080)1.70837597
138Increased circulating renin level (HP:0000848)1.69419358
139Relative macrocephaly (HP:0004482)1.69353950
140Mild short stature (HP:0003502)1.68028076
141Bladder neoplasm (HP:0009725)1.67880207
142Bladder carcinoma (HP:0002862)1.67880207
143Transitional cell carcinoma of the bladder (HP:0006740)1.67215865
144Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.64352690
145Macroorchidism (HP:0000053)1.63050646
146Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.63016000
147Memory impairment (HP:0002354)1.59519261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.72120761
2RIPK45.35499212
3NTRK34.98996473
4MAP3K42.66739160
5MAP3K92.66142568
6BMPR22.53707940
7MINK12.28989406
8CASK2.28861155
9PNCK2.21832568
10MAP2K72.21091690
11PLK22.18791099
12STK38L2.05162341
13IRAK32.01438678
14MAP3K121.90018854
15KSR21.88688514
16SIK21.86216811
17DAPK21.81598916
18KSR11.81005909
19MUSK1.75633208
20DAPK11.71244692
21NTRK11.69166762
22NME11.66439594
23MAP3K131.64902426
24PTK2B1.63725997
25MAP2K41.62678893
26STK241.60347649
27ARAF1.57337002
28MARK11.52134896
29FES1.50443909
30PAK61.49409149
31TNIK1.43212714
32CDK51.36952336
33CAMK2B1.36740800
34GRK51.34813561
35CAMK2A1.29655237
36FGR1.26826731
37RAF11.26060100
38PRPF4B1.21670461
39PRKCG1.18745902
40NEK61.15426146
41BRD41.15165131
42NTRK21.11196749
43CAMK1D1.03425681
44WNK11.01875147
45DDR21.01642158
46CAMKK11.00293089
47MAP3K20.90021346
48MAP3K50.89397717
49MAP3K140.88457303
50ERBB30.87982303
51RIPK10.86163830
52TAOK20.84838231
53STK380.84684432
54GRK70.83823591
55TRIM280.83175813
56SGK10.82831932
57PRKD30.82237916
58MAPK130.81753174
59FER0.80615553
60DYRK1A0.80098640
61IRAK20.78389039
62CAMK2D0.77920463
63DMPK0.76627701
64CCNB10.75660777
65PDGFRB0.75497857
66PDGFRA0.73196388
67PIK3CA0.72402045
68JAK10.69619046
69GRK60.68254941
70STK390.67175634
71PRKCE0.67136651
72CDK180.63732730
73ACVR1B0.63314869
74CAMKK20.63116804
75CDK140.62898329
76LATS10.61304697
77CDK150.59843128
78CAMK10.59042275
79AKT30.58857524
80MAP3K70.58445965
81MKNK20.58440516
82CAMK40.58225398
83MELK0.57577672
84PRKCQ0.56233364
85CDK190.55185570
86MAP2K10.54153650
87ALK0.53441899
88BRAF0.52015610
89TNK20.51356744
90TYRO30.51191003
91CDK11A0.50285340
92SGK4940.49819574
93SGK2230.49819574
94SGK20.49665457
95STK30.49241726
96STK110.49135116
97ROCK20.48699344
98PAK30.48291115
99MAP3K10.47458967
100PDPK10.46396842
101FYN0.46215327
102PRKCZ0.45571139
103RET0.44784974
104MARK20.44689919
105MAPK100.44591101
106SIK30.44340703
107OXSR10.42259891
108CAMK2G0.42170112
109PDK10.41766244
110MOS0.41591116
111MAPK70.40099112
112BCR0.38972820
113CAMK1G0.37143389
114UHMK10.35870525
115RPS6KA30.35224079
116PINK10.34872878
117MAP3K60.34762702
118CSNK1G20.32788746
119PRKCB0.31417879
120SYK0.30799868
121* PRKACA0.29934027
122* PRKCA0.29001488
123CSNK1E0.26820322
124SGK30.25985729
125MAPK120.24967487
126PRKG10.24777787
127LATS20.24769040
128PRKCH0.24132837
129PRKD20.21385186
130CSNK1A10.20329816

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.44288391
2Long-term potentiation_Homo sapiens_hsa047203.34026839
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.01566481
4Circadian entrainment_Homo sapiens_hsa047132.91895689
5Amphetamine addiction_Homo sapiens_hsa050312.86100828
6Glutamatergic synapse_Homo sapiens_hsa047242.79523737
7Morphine addiction_Homo sapiens_hsa050322.60211234
8GABAergic synapse_Homo sapiens_hsa047272.52678580
9* Salivary secretion_Homo sapiens_hsa049702.32298966
10Olfactory transduction_Homo sapiens_hsa047402.29757128
11Dopaminergic synapse_Homo sapiens_hsa047282.28873939
12Synaptic vesicle cycle_Homo sapiens_hsa047212.28493116
13Renin secretion_Homo sapiens_hsa049242.19675777
14Taste transduction_Homo sapiens_hsa047422.15145703
15Long-term depression_Homo sapiens_hsa047302.03168771
16Serotonergic synapse_Homo sapiens_hsa047261.94336485
17* Calcium signaling pathway_Homo sapiens_hsa040201.86465443
18Oxytocin signaling pathway_Homo sapiens_hsa049211.83511398
19Insulin secretion_Homo sapiens_hsa049111.81640393
20Gastric acid secretion_Homo sapiens_hsa049711.81199753
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79590952
22* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77993821
23Cholinergic synapse_Homo sapiens_hsa047251.73254827
24Cocaine addiction_Homo sapiens_hsa050301.49453797
25Collecting duct acid secretion_Homo sapiens_hsa049661.46889517
26GnRH signaling pathway_Homo sapiens_hsa049121.46610490
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45169236
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43218397
29* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36119779
30Gap junction_Homo sapiens_hsa045401.35652114
31* cAMP signaling pathway_Homo sapiens_hsa040241.31859257
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27783902
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27481911
34Phototransduction_Homo sapiens_hsa047441.21718070
35Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.20835584
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20754866
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20112034
38Axon guidance_Homo sapiens_hsa043601.19924252
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18700817
40* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15051155
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14218780
42Estrogen signaling pathway_Homo sapiens_hsa049151.08384530
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.08059653
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07741032
45Osteoclast differentiation_Homo sapiens_hsa043801.06854523
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06603391
47Melanogenesis_Homo sapiens_hsa049161.05633781
48Glioma_Homo sapiens_hsa052141.04723348
49Endometrial cancer_Homo sapiens_hsa052131.03163074
50Cardiac muscle contraction_Homo sapiens_hsa042600.99286805
51African trypanosomiasis_Homo sapiens_hsa051430.98755349
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98694797
53Proteoglycans in cancer_Homo sapiens_hsa052050.94630571
54Type II diabetes mellitus_Homo sapiens_hsa049300.94538764
55Amoebiasis_Homo sapiens_hsa051460.93383554
56VEGF signaling pathway_Homo sapiens_hsa043700.92512539
57* Pancreatic secretion_Homo sapiens_hsa049720.91184034
58Vibrio cholerae infection_Homo sapiens_hsa051100.89702147
59Alzheimers disease_Homo sapiens_hsa050100.88297513
60TNF signaling pathway_Homo sapiens_hsa046680.88031583
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87789952
62Choline metabolism in cancer_Homo sapiens_hsa052310.87393201
63Prolactin signaling pathway_Homo sapiens_hsa049170.84171138
64ErbB signaling pathway_Homo sapiens_hsa040120.82783353
65Leishmaniasis_Homo sapiens_hsa051400.82003839
66Thyroid hormone synthesis_Homo sapiens_hsa049180.78564869
67Oocyte meiosis_Homo sapiens_hsa041140.78231057
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.73684388
69Legionellosis_Homo sapiens_hsa051340.73477082
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73024628
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72901954
72Adherens junction_Homo sapiens_hsa045200.72013437
73Chronic myeloid leukemia_Homo sapiens_hsa052200.71258737
74Dilated cardiomyopathy_Homo sapiens_hsa054140.70591375
75Colorectal cancer_Homo sapiens_hsa052100.70256687
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67845388
77MAPK signaling pathway_Homo sapiens_hsa040100.67340914
78Dorso-ventral axis formation_Homo sapiens_hsa043200.67150902
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66563446
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66421039
81Pancreatic cancer_Homo sapiens_hsa052120.66164382
82HIF-1 signaling pathway_Homo sapiens_hsa040660.64568834
83FoxO signaling pathway_Homo sapiens_hsa040680.63897908
84Glucagon signaling pathway_Homo sapiens_hsa049220.63895831
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62503607
86Endocytosis_Homo sapiens_hsa041440.61232394
87Pertussis_Homo sapiens_hsa051330.60025437
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59998781
89Rap1 signaling pathway_Homo sapiens_hsa040150.59985998
90Ras signaling pathway_Homo sapiens_hsa040140.58200023
91Toxoplasmosis_Homo sapiens_hsa051450.57666094
92MicroRNAs in cancer_Homo sapiens_hsa052060.56718878
93Hepatitis B_Homo sapiens_hsa051610.56287667
94Phagosome_Homo sapiens_hsa041450.55701292
95Focal adhesion_Homo sapiens_hsa045100.55345486
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54095191
97Inositol phosphate metabolism_Homo sapiens_hsa005620.52988313
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50695649
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49830440
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48784040
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.48731845
102Wnt signaling pathway_Homo sapiens_hsa043100.46251373
103Oxidative phosphorylation_Homo sapiens_hsa001900.43446845
104Circadian rhythm_Homo sapiens_hsa047100.38724260
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38670094
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38309993
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38221040
108Non-small cell lung cancer_Homo sapiens_hsa052230.37966470
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.37744541
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37198497
111Prion diseases_Homo sapiens_hsa050200.34686107
112Alcoholism_Homo sapiens_hsa050340.33896758
113Bile secretion_Homo sapiens_hsa049760.33735659
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33001176
115mTOR signaling pathway_Homo sapiens_hsa041500.32147667
116Rheumatoid arthritis_Homo sapiens_hsa053230.29540434
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29397576
118B cell receptor signaling pathway_Homo sapiens_hsa046620.28169134
119Chemokine signaling pathway_Homo sapiens_hsa040620.27905766
120Type I diabetes mellitus_Homo sapiens_hsa049400.27209725
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25810510
122Platelet activation_Homo sapiens_hsa046110.24703502
123Salmonella infection_Homo sapiens_hsa051320.24375210
124Renal cell carcinoma_Homo sapiens_hsa052110.23267284
125T cell receptor signaling pathway_Homo sapiens_hsa046600.21655869
126Tuberculosis_Homo sapiens_hsa051520.21209182
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19917446
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19217519
129Ovarian steroidogenesis_Homo sapiens_hsa049130.19101272

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