ATP2B4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.39243536
2vocalization behavior (GO:0071625)4.25246218
3collagen fibril organization (GO:0030199)4.22024550
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.14686073
5neuron cell-cell adhesion (GO:0007158)4.00842073
6regulation of short-term neuronal synaptic plasticity (GO:0048172)3.95451336
7protein heterotrimerization (GO:0070208)3.92291877
8ionotropic glutamate receptor signaling pathway (GO:0035235)3.84594184
9presynaptic membrane assembly (GO:0097105)3.73745156
10skin morphogenesis (GO:0043589)3.71832857
11protein localization to synapse (GO:0035418)3.70218616
12cell migration involved in heart development (GO:0060973)3.69572422
13sequestering of extracellular ligand from receptor (GO:0035581)3.67869691
14postsynaptic membrane organization (GO:0001941)3.65923908
15locomotory exploration behavior (GO:0035641)3.64955332
16extracellular matrix assembly (GO:0085029)3.63477370
17regulation of glutamate receptor signaling pathway (GO:1900449)3.62359982
18dendritic spine morphogenesis (GO:0060997)3.59453071
19endodermal cell differentiation (GO:0035987)3.55278789
20glutamate receptor signaling pathway (GO:0007215)3.43911958
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.41690400
22negative regulation of synaptic transmission, GABAergic (GO:0032229)3.39955726
23presynaptic membrane organization (GO:0097090)3.28090019
24hypotonic response (GO:0006971)3.27737163
25cell-substrate junction assembly (GO:0007044)3.25893888
26neuronal action potential propagation (GO:0019227)3.25882482
27hemidesmosome assembly (GO:0031581)3.21195083
28cell adhesion mediated by integrin (GO:0033627)3.20079113
29kidney mesenchyme development (GO:0072074)3.17803585
30bone trabecula formation (GO:0060346)3.14295927
31synaptic vesicle maturation (GO:0016188)3.13804854
32righting reflex (GO:0060013)3.13216233
33long-term memory (GO:0007616)3.11446314
34barbed-end actin filament capping (GO:0051016)3.10252454
35synaptic vesicle exocytosis (GO:0016079)3.08870995
36vascular endothelial growth factor signaling pathway (GO:0038084)3.08495958
37neuron recognition (GO:0008038)3.07821481
38positive regulation of blood vessel endothelial cell migration (GO:0043536)3.07600770
39cerebellar Purkinje cell differentiation (GO:0021702)3.06503013
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.06469023
41endocardial cushion development (GO:0003197)3.06182542
42regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04771349
43chondrocyte proliferation (GO:0035988)3.02721700
44synaptic transmission, glutamatergic (GO:0035249)3.00938989
45L-amino acid import (GO:0043092)3.00502985
46metanephric mesenchyme development (GO:0072075)2.99611920
47pericardium development (GO:0060039)2.98431153
48glutamate secretion (GO:0014047)2.98201291
49regulation of excitatory postsynaptic membrane potential (GO:0060079)2.96201299
50regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.95323795
51extracellular fibril organization (GO:0043206)2.94585793
52regulation of ARF protein signal transduction (GO:0032012)2.94141011
53regulation of synaptic vesicle exocytosis (GO:2000300)2.93737503
54gamma-aminobutyric acid signaling pathway (GO:0007214)2.91255736
55positive regulation of fibroblast migration (GO:0010763)2.89457791
56regulation of postsynaptic membrane potential (GO:0060078)2.89258329
57exploration behavior (GO:0035640)2.89234884
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.89191615
59transmission of nerve impulse (GO:0019226)2.88277596
60blood vessel maturation (GO:0001955)2.87074810
61layer formation in cerebral cortex (GO:0021819)2.87032557
62venous blood vessel morphogenesis (GO:0048845)2.86962818
63basement membrane organization (GO:0071711)2.85694313
64collagen metabolic process (GO:0032963)2.84299029
65desmosome organization (GO:0002934)2.83183374
66substrate-dependent cell migration (GO:0006929)2.82798384
67neuron-neuron synaptic transmission (GO:0007270)2.82612022
68regulation of long-term neuronal synaptic plasticity (GO:0048169)2.81326909
69regulation of vesicle fusion (GO:0031338)2.81302808
70positive regulation of membrane potential (GO:0045838)2.79844765
71negative regulation of smooth muscle cell migration (GO:0014912)2.78333613
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.76637423
73cell migration involved in sprouting angiogenesis (GO:0002042)2.76256966
74mesenchymal-epithelial cell signaling (GO:0060638)2.75471211
75positive regulation of receptor recycling (GO:0001921)2.73483123
76fibril organization (GO:0097435)2.73164601
77glycine transport (GO:0015816)2.72260293
78mating behavior (GO:0007617)2.71645804
79positive regulation of synaptic transmission, GABAergic (GO:0032230)2.71540865
80positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.70956133
81cytoskeletal anchoring at plasma membrane (GO:0007016)2.70425627
82collagen catabolic process (GO:0030574)2.68688055
83proline transport (GO:0015824)2.67243915
84axonal fasciculation (GO:0007413)2.67067788
85regulation of neuronal synaptic plasticity (GO:0048168)2.66878387
86regulation of transforming growth factor beta2 production (GO:0032909)2.65962510
87positive regulation of neurotransmitter secretion (GO:0001956)2.65140250
88adherens junction assembly (GO:0034333)2.64730770
89retina vasculature morphogenesis in camera-type eye (GO:0061299)2.64414950
90chemosensory behavior (GO:0007635)2.64121316
91regulation of axon extension involved in axon guidance (GO:0048841)2.63472219
92regulation of dendritic spine development (GO:0060998)2.63020894
93stress fiber assembly (GO:0043149)2.62665392
94response to methylmercury (GO:0051597)2.62575055
95multicellular organismal macromolecule metabolic process (GO:0044259)2.62195399
96membrane depolarization (GO:0051899)2.61791175
97G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61763607
98limb bud formation (GO:0060174)2.60931725
99positive regulation of dendritic spine development (GO:0060999)2.60318765
100protein localization to endosome (GO:0036010)2.60290606
101negative regulation of fatty acid transport (GO:2000192)2.60239266
102planar cell polarity pathway involved in neural tube closure (GO:0090179)2.59082234
103regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.58354720
104type B pancreatic cell proliferation (GO:0044342)2.57996642
105focal adhesion assembly (GO:0048041)2.57574837
106cell-substrate adherens junction assembly (GO:0007045)2.57574837
107regulation of extracellular matrix disassembly (GO:0010715)2.57373199
108regulation of synaptic transmission, glutamatergic (GO:0051966)2.56449916
109fibroblast migration (GO:0010761)2.56090565
110negative regulation of neurotransmitter transport (GO:0051589)2.56003810
111protein localization to cell surface (GO:0034394)2.55869522
112regulation of neurotransmitter secretion (GO:0046928)2.55742006
113regulation of dendritic spine morphogenesis (GO:0061001)2.55212638
114cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.55149221
115regulation of synaptic vesicle transport (GO:1902803)2.54619326
116chondrocyte development (GO:0002063)2.53783107
117retina layer formation (GO:0010842)2.53423312
118regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.52503212
119auditory behavior (GO:0031223)2.52497398
120atrioventricular valve morphogenesis (GO:0003181)2.51480742
121positive regulation of action potential (GO:0045760)2.50979836
122negative regulation of axon extension involved in axon guidance (GO:0048843)2.50680936
123neuronal ion channel clustering (GO:0045161)2.50654086
124startle response (GO:0001964)2.50454424
125smooth muscle tissue development (GO:0048745)2.49899898
126multicellular organismal metabolic process (GO:0044236)2.48704964
127insulin-like growth factor receptor signaling pathway (GO:0048009)2.48668209
128cellular response to vitamin (GO:0071295)2.48565407
129synaptic vesicle docking involved in exocytosis (GO:0016081)2.48180128
130extracellular matrix disassembly (GO:0022617)2.47282363
131dendrite morphogenesis (GO:0048813)2.47176241
132positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.47084319
133synapse assembly (GO:0007416)2.46876591
134cortical actin cytoskeleton organization (GO:0030866)2.46312738
135vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.46227088
136regulation of cardioblast differentiation (GO:0051890)2.45155800
137regulation of synaptic transmission, GABAergic (GO:0032228)2.44700064
138detection of calcium ion (GO:0005513)2.43847507
139regulation of respiratory gaseous exchange (GO:0043576)2.43426973
140G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.43003725
141multicellular organismal catabolic process (GO:0044243)2.42538494
142dermatan sulfate biosynthetic process (GO:0030208)2.42106597
143sprouting angiogenesis (GO:0002040)2.42102320
144membrane depolarization during action potential (GO:0086010)2.41953623
145neurotransmitter-gated ion channel clustering (GO:0072578)2.41887298
146membrane assembly (GO:0071709)2.41592849
147neurotransmitter secretion (GO:0007269)2.41510949
148membrane hyperpolarization (GO:0060081)2.39103192
149regulation of inositol phosphate biosynthetic process (GO:0010919)2.38964703
150negative regulation of osteoblast proliferation (GO:0033689)2.38952116
151regulation of respiratory system process (GO:0044065)2.38933032
152gamma-aminobutyric acid transport (GO:0015812)2.38853813
153dermatan sulfate metabolic process (GO:0030205)2.38810918
154response to auditory stimulus (GO:0010996)2.38581253
155substrate adhesion-dependent cell spreading (GO:0034446)2.38292805
156endothelial cell morphogenesis (GO:0001886)2.38279400
157heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.38138143
158axon extension involved in axon guidance (GO:0048846)2.38084550
159neuron projection extension involved in neuron projection guidance (GO:1902284)2.38084550
160positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.37756194
161cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.36631635
162positive regulation of synapse assembly (GO:0051965)2.36054977
163negative regulation of neurotransmitter secretion (GO:0046929)2.35462303
164positive regulation of endothelial cell apoptotic process (GO:2000353)2.35457498
165activation of protein kinase A activity (GO:0034199)2.34628279
166cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.33935986
167positive regulation of neurotransmitter transport (GO:0051590)2.33275894
168regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.32858883
169neurotransmitter transport (GO:0006836)2.32142792
170response to histamine (GO:0034776)2.32109924
171negative regulation of anoikis (GO:2000811)2.30467740
172regulation of axon guidance (GO:1902667)2.30315118
173response to fluid shear stress (GO:0034405)2.30225200
174extracellular matrix organization (GO:0030198)2.29981697
175positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.29443348
176regulation of protein kinase A signaling (GO:0010738)2.28910837
177extracellular structure organization (GO:0043062)2.28908537
178G-protein coupled receptor internalization (GO:0002031)2.28880732
179negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.28822593
180central nervous system projection neuron axonogenesis (GO:0021952)2.28665792
181regulation of neurotransmitter transport (GO:0051588)2.28447123
182peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.28191349
183glomerular basement membrane development (GO:0032836)2.27995250
184negative regulation of chondrocyte differentiation (GO:0032331)2.27893096
185negative regulation of BMP signaling pathway (GO:0030514)2.27848029
186cardiac myofibril assembly (GO:0055003)2.27423647
187learning (GO:0007612)2.27388661
188dendritic spine organization (GO:0097061)2.27230394
189regulation of synaptic plasticity (GO:0048167)2.26209719
190cortical cytoskeleton organization (GO:0030865)2.26079248
191dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.25869000
192long-term synaptic potentiation (GO:0060291)2.25682607
193apoptotic cell clearance (GO:0043277)2.25421780
194cell communication by electrical coupling (GO:0010644)2.25360586
195regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.24774868
196blood vessel endothelial cell migration (GO:0043534)2.24194668
197regulation of integrin-mediated signaling pathway (GO:2001044)2.23991737
198positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.23348610
199wound healing, spreading of epidermal cells (GO:0035313)2.23211426
200platelet-derived growth factor receptor signaling pathway (GO:0048008)2.21464397

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.91705950
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.63298756
3GBX2_23144817_ChIP-Seq_PC3_Human3.31868745
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85912212
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.79464525
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74029426
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55010765
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.51318231
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.41006302
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39766323
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39766323
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.35592296
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35540393
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34480519
15* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.33870459
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32273213
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32242800
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.25493120
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24426542
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.13065284
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12137911
22* WT1_19549856_ChIP-ChIP_CCG9911_Human2.09005890
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03064759
24DROSHA_22980978_ChIP-Seq_HELA_Human2.01590835
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.96909053
26AR_21572438_ChIP-Seq_LNCaP_Human1.93611697
27* BRD4_25478319_ChIP-Seq_HGPS_Human1.92842890
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92123438
29TAF15_26573619_Chip-Seq_HEK293_Human1.90098769
30CJUN_26792858_Chip-Seq_BT549_Human1.89326703
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.88783288
32CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.86476853
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.85638407
34* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.83541298
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81270937
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.78427755
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.76682226
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76500901
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75810401
40* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.73857530
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.69268193
42REST_21632747_ChIP-Seq_MESCs_Mouse1.67123981
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65927247
44CLOCK_20551151_ChIP-Seq_293T_Human1.65366733
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65175156
46SOX9_24532713_ChIP-Seq_HFSC_Mouse1.64689057
47CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.63016298
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.61940645
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.61940645
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61851407
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.59309668
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.57414455
53SMAD4_21799915_ChIP-Seq_A2780_Human1.55815564
54* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54280359
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53655914
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53602086
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53460719
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52359237
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52359048
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50302130
61P300_19829295_ChIP-Seq_ESCs_Human1.49025904
62TBX20_22328084_ChIP-Seq_HEART_Mouse1.48853585
63TBX20_22080862_ChIP-Seq_HEART_Mouse1.48853585
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.45668673
65* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45027247
66GATA1_22025678_ChIP-Seq_K562_Human1.43616987
67* SMAD3_21741376_ChIP-Seq_EPCs_Human1.43029583
68CTNNB1_20460455_ChIP-Seq_HCT116_Human1.42312931
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40692939
70TP53_16413492_ChIP-PET_HCT116_Human1.40114830
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38554978
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37432857
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36328322
74* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32561927
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32300216
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.30663084
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30072627
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30013544
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30013544
80RARB_27405468_Chip-Seq_BRAIN_Mouse1.27859154
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26628197
82DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23363153
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22212251
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.22182472
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.20706123
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20495259
87RNF2_27304074_Chip-Seq_NSC_Mouse1.19943632
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19713431
89TP53_18474530_ChIP-ChIP_U2OS_Human1.19034463
90STAT3_23295773_ChIP-Seq_U87_Human1.18948548
91NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18793660
92AR_25329375_ChIP-Seq_VCAP_Human1.18691820
93STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.18499742
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18234982
95IGF1R_20145208_ChIP-Seq_DFB_Human1.18195996
96* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17972598
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17949582
98SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17092674
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16527466
100* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.16447751
101* ELK3_25401928_ChIP-Seq_HUVEC_Human1.15766442
102AHR_22903824_ChIP-Seq_MCF-7_Human1.15676483
103* TCF4_23295773_ChIP-Seq_U87_Human1.15585952
104NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14584923
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14464203
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14257592
107ISL1_27105846_Chip-Seq_CPCs_Mouse1.14210096
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13757808
109* NANOG_18555785_Chip-Seq_ESCs_Mouse1.13648384
110* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13427838
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.13224478
112CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10937110
113FUS_26573619_Chip-Seq_HEK293_Human1.09245689
114* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08701737
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08359647
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08359647
117* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07146655
118* KDM2B_26808549_Chip-Seq_K562_Human1.07113269
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06905062
120* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06744684
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05826277
122ER_23166858_ChIP-Seq_MCF-7_Human1.05465638
123STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05332382
124SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04920259
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04781102
126RUNX2_22187159_ChIP-Seq_PCA_Human1.04590315
127TP53_23651856_ChIP-Seq_MEFs_Mouse1.04051123
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03655618
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03256306
130* REST_18959480_ChIP-ChIP_MESCs_Mouse1.02818308
131HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02302181
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02135909
133* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01965569
134FOXO3_23340844_ChIP-Seq_DLD1_Human1.01791165
135TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01737331
136* AR_19668381_ChIP-Seq_PC3_Human1.01526936
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01225797
138SMAD3_21741376_ChIP-Seq_HESCs_Human1.01147237
139RING1B_27294783_Chip-Seq_NPCs_Mouse1.00500361
140EGR1_19374776_ChIP-ChIP_THP-1_Human1.00013521
141KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99380485
142JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99206361
143* E2F1_18555785_Chip-Seq_ESCs_Mouse0.98598259
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98454293
145MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98032737
146NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96810268
147VDR_22108803_ChIP-Seq_LS180_Human0.96734132
148JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96488312
149YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96482416
150EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96392704
151* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94946665
152P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94481308
153* NFE2_27457419_Chip-Seq_LIVER_Mouse0.94401761
154* P53_22387025_ChIP-Seq_ESCs_Mouse0.93427212
155PRDM14_20953172_ChIP-Seq_ESCs_Human0.93244614
156MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92906373
157* CMYC_18555785_Chip-Seq_ESCs_Mouse0.92543636
158* TP63_23658742_ChIP-Seq_EP156T_Human0.89968414
159ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89480183
160UBF1/2_26484160_Chip-Seq_HMECs_Human0.88751575
161HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88167582
162ESR1_20079471_ChIP-ChIP_T-47D_Human0.86615962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.96956470
2MP0004859_abnormal_synaptic_plasticity4.83713337
3MP0005275_abnormal_skin_tensile4.44579592
4MP0003705_abnormal_hypodermis_morpholog4.19602817
5MP0001958_emphysema4.10788449
6MP0005503_abnormal_tendon_morphology4.03420359
7MP0003880_abnormal_central_pattern3.78607044
8MP0003279_aneurysm3.77524400
9MP0004272_abnormal_basement_membrane3.51372096
10MP0003635_abnormal_synaptic_transmissio3.17726038
11MP0010368_abnormal_lymphatic_system2.88915554
12MP0009745_abnormal_behavioral_response2.84574908
13MP0004270_analgesia2.76522278
14MP0003566_abnormal_cell_adhesion2.66527978
15MP0009046_muscle_twitch2.62274525
16MP0001486_abnormal_startle_reflex2.58110371
17MP0002064_seizures2.46087737
18MP0001968_abnormal_touch/_nociception2.41854816
19MP0002063_abnormal_learning/memory/cond2.40370621
20MP0003950_abnormal_plasma_membrane2.39624501
21MP0001501_abnormal_sleep_pattern2.38950869
22MP0005409_darkened_coat_color2.38891045
23MP0005423_abnormal_somatic_nervous2.38144336
24MP0003787_abnormal_imprinting2.35575807
25MP0002572_abnormal_emotion/affect_behav2.29350404
26MP0003091_abnormal_cell_migration2.27324902
27MP0009384_cardiac_valve_regurgitation2.23148064
28MP0001188_hyperpigmentation2.22840541
29MP0005257_abnormal_intraocular_pressure2.21308315
30MP0002734_abnormal_mechanical_nocicepti2.07881873
31MP0002102_abnormal_ear_morphology2.06245201
32MP0000767_abnormal_smooth_muscle2.05812867
33MP0002272_abnormal_nervous_system2.04953924
34MP0005023_abnormal_wound_healing1.99361933
35MP0004084_abnormal_cardiac_muscle1.92335722
36MP0009780_abnormal_chondrocyte_physiolo1.81606436
37MP0002877_abnormal_melanocyte_morpholog1.81385253
38MP0006054_spinal_hemorrhage1.81316187
39* MP0001440_abnormal_grooming_behavior1.80213193
40MP0002060_abnormal_skin_morphology1.77827557
41MP0001542_abnormal_bone_strength1.77369286
42MP0005645_abnormal_hypothalamus_physiol1.76469421
43MP0003136_yellow_coat_color1.75836126
44MP0001970_abnormal_pain_threshold1.75561248
45MP0002067_abnormal_sensory_capabilities1.72223678
46MP0004147_increased_porphyrin_level1.70593175
47MP0002733_abnormal_thermal_nociception1.62852556
48MP0008569_lethality_at_weaning1.61548796
49MP0002735_abnormal_chemical_nociception1.61513125
50MP0002557_abnormal_social/conspecific_i1.60429651
51MP0005508_abnormal_skeleton_morphology1.59801940
52MP0003828_pulmonary_edema1.59580971
53MP0003879_abnormal_hair_cell1.51975040
54MP0002736_abnormal_nociception_after1.50203291
55MP0004742_abnormal_vestibular_system1.49141648
56MP0004036_abnormal_muscle_relaxation1.47981891
57MP0002295_abnormal_pulmonary_circulatio1.46636421
58MP0002108_abnormal_muscle_morphology1.44795214
59MP0001879_abnormal_lymphatic_vessel1.44295854
60MP0002896_abnormal_bone_mineralization1.42203793
61MP0010352_gastrointestinal_tract_polyps1.42083141
62MP0000778_abnormal_nervous_system1.40630487
63MP0001299_abnormal_eye_distance/1.35695109
64MP0000013_abnormal_adipose_tissue1.34283668
65MP0002184_abnormal_innervation1.33546721
66MP0003300_gastrointestinal_ulcer1.33544491
67MP0005646_abnormal_pituitary_gland1.33465685
68MP0000534_abnormal_ureter_morphology1.32361314
69MP0006276_abnormal_autonomic_nervous1.32009820
70MP0008995_early_reproductive_senescence1.31544499
71MP0006138_congestive_heart_failure1.30388826
72MP0000733_abnormal_muscle_development1.28305574
73MP0000751_myopathy1.25258460
74MP0004510_myositis1.22221504
75MP0004145_abnormal_muscle_electrophysio1.18569152
76* MP0005595_abnormal_vascular_smooth1.18129961
77MP0004381_abnormal_hair_follicle1.18048596
78MP0003941_abnormal_skin_development1.17663573
79MP0005386_behavior/neurological_phenoty1.13932105
80MP0004924_abnormal_behavior1.13932105
81MP0002822_catalepsy1.13731149
82MP0005388_respiratory_system_phenotype1.13507259
83MP0002133_abnormal_respiratory_system1.13507259
84MP0003045_fibrosis1.12032858
85MP0002882_abnormal_neuron_morphology1.11545127
86MP0002009_preneoplasia1.10788951
87MP0003633_abnormal_nervous_system1.09092429
88MP0002876_abnormal_thyroid_physiology1.08797260
89MP0003122_maternal_imprinting1.07758597
90MP0005670_abnormal_white_adipose1.07244548
91MP0002128_abnormal_blood_circulation1.06602883
92MP0010386_abnormal_urinary_bladder1.05624140
93MP0000955_abnormal_spinal_cord1.04698839
94MP0000003_abnormal_adipose_tissue1.04547527
95MP0000631_abnormal_neuroendocrine_gland1.03854611
96MP0004885_abnormal_endolymph1.03570466
97MP0000920_abnormal_myelination1.01488420
98* MP0002066_abnormal_motor_capabilities/c1.01484565
99MP0001243_abnormal_dermal_layer1.01258568
100MP0004811_abnormal_neuron_physiology0.98852973
101MP0001348_abnormal_lacrimal_gland0.98695114
102MP0004484_altered_response_of0.98452000
103MP0000749_muscle_degeneration0.97150721
104MP0002249_abnormal_larynx_morphology0.97122352
105MP0001905_abnormal_dopamine_level0.97084207
106MP0003385_abnormal_body_wall0.95565163
107MP0004087_abnormal_muscle_fiber0.95208032
108MP0003942_abnormal_urinary_system0.94893919
109MP0003191_abnormal_cellular_cholesterol0.94168476
110MP0000759_abnormal_skeletal_muscle0.93904715
111MP0004130_abnormal_muscle_cell0.93880302
112MP0005623_abnormal_meninges_morphology0.93385958
113MP0000428_abnormal_craniofacial_morphol0.93369345
114MP0005164_abnormal_response_to0.93100593
115MP0005390_skeleton_phenotype0.91810619
116MP0004142_abnormal_muscle_tone0.91105386
117MP0001963_abnormal_hearing_physiology0.90820174
118MP0005551_abnormal_eye_electrophysiolog0.90678037
119MP0001849_ear_inflammation0.90522391
120MP0000762_abnormal_tongue_morphology0.89585639
121MP0001614_abnormal_blood_vessel0.89063511
122MP0005310_abnormal_salivary_gland0.88713043
123MP0003690_abnormal_glial_cell0.88413286
124MP0001664_abnormal_digestion0.86783462
125MP0000462_abnormal_digestive_system0.86155385
126MP0001502_abnormal_circadian_rhythm0.84870990
127MP0006072_abnormal_retinal_apoptosis0.84361465
128MP0000015_abnormal_ear_pigmentation0.83860941
129MP0001984_abnormal_olfaction0.83151386
130MP0003631_nervous_system_phenotype0.83051976
131MP0006292_abnormal_olfactory_placode0.82476260
132MP0004858_abnormal_nervous_system0.82180046
133MP0005375_adipose_tissue_phenotype0.81920891
134MP0005535_abnormal_body_temperature0.81397567
135* MP0005620_abnormal_muscle_contractility0.81324313
136MP0002796_impaired_skin_barrier0.81158686
137MP0002925_abnormal_cardiovascular_devel0.80913156
138MP0004134_abnormal_chest_morphology0.80616261
139MP0008872_abnormal_physiological_respon0.80490017
140MP0010630_abnormal_cardiac_muscle0.80062848
141MP0002152_abnormal_brain_morphology0.79879945
142MP0004085_abnormal_heartbeat0.79811920
143MP0002168_other_aberrant_phenotype0.79231469
144MP0000026_abnormal_inner_ear0.78936784
145MP0005330_cardiomyopathy0.78820884
146MP0009053_abnormal_anal_canal0.78192316
147MP0002998_abnormal_bone_remodeling0.77079563
148MP0002638_abnormal_pupillary_reflex0.77040678
149MP0003938_abnormal_ear_development0.76887717
150MP0009250_abnormal_appendicular_skeleto0.76204540
151MP0001915_intracranial_hemorrhage0.75818021
152MP0008004_abnormal_stomach_pH0.75410543
153MP0001851_eye_inflammation0.74560922
154MP0002972_abnormal_cardiac_muscle0.73800238
155MP0002752_abnormal_somatic_nervous0.73565705
156MP0002115_abnormal_skeleton_extremities0.72971113
157MP0000569_abnormal_digit_pigmentation0.72102501
158MP0002069_abnormal_eating/drinking_beha0.70094732
159MP0010030_abnormal_orbit_morphology0.69924236
160MP0008874_decreased_physiological_sensi0.69657421
161MP0002229_neurodegeneration0.69256840
162MP0001661_extended_life_span0.69193490
163MP0001175_abnormal_lung_morphology0.68929753
164MP0002837_dystrophic_cardiac_calcinosis0.68204182
165MP0004883_abnormal_blood_vessel0.67830802
166MP0003115_abnormal_respiratory_system0.67658126
167MP0002127_abnormal_cardiovascular_syste0.66752263
168MP0000163_abnormal_cartilage_morphology0.66461223
169MP0008775_abnormal_heart_ventricle0.66173529
170MP0001544_abnormal_cardiovascular_syste0.65348298
171MP0005385_cardiovascular_system_phenoty0.65348298
172MP0003448_altered_tumor_morphology0.65314368
173MP0003283_abnormal_digestive_organ0.64910084
174MP0000383_abnormal_hair_follicle0.64832923
175MP0002933_joint_inflammation0.64355537
176MP0005165_increased_susceptibility_to0.63511396
177MP0003329_amyloid_beta_deposits0.62562021
178MP0005379_endocrine/exocrine_gland_phen0.62219090
179MP0005174_abnormal_tail_pigmentation0.61937304
180MP0003315_abnormal_perineum_morphology0.61728266
181MP0002177_abnormal_outer_ear0.61005747
182MP0005666_abnormal_adipose_tissue0.60837849
183MP0005171_absent_coat_pigmentation0.60615755
184MP0004185_abnormal_adipocyte_glucose0.60572174
185MP0001177_atelectasis0.60511137
186MP0001784_abnormal_fluid_regulation0.60440085
187MP0000266_abnormal_heart_morphology0.60054492

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.35352543
2Premature rupture of membranes (HP:0001788)6.10313259
3Aortic aneurysm (HP:0004942)5.20882533
4Aortic dissection (HP:0002647)5.12470287
5Focal motor seizures (HP:0011153)5.04432000
6Febrile seizures (HP:0002373)4.94093591
7Focal seizures (HP:0007359)4.86042101
8Vascular tortuosity (HP:0004948)4.43901440
9Epileptic encephalopathy (HP:0200134)4.29204587
10Arterial tortuosity (HP:0005116)4.13212272
11Absent/shortened dynein arms (HP:0200106)3.90541910
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.90541910
13Atrophic scars (HP:0001075)3.81727998
14Abnormal ciliary motility (HP:0012262)3.71538808
15Soft skin (HP:0000977)3.55905174
16Ankle contracture (HP:0006466)3.51641379
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.51066924
18Hemiparesis (HP:0001269)3.45231556
19Generalized tonic-clonic seizures (HP:0002069)3.44308343
20Wormian bones (HP:0002645)3.41709096
21Abnormal respiratory motile cilium physiology (HP:0012261)3.36181714
22Dilatation of the ascending aorta (HP:0005111)3.34558201
23Follicular hyperkeratosis (HP:0007502)3.34353910
24Bladder diverticulum (HP:0000015)3.24023089
25Progressive cerebellar ataxia (HP:0002073)3.23494616
26Neonatal short-limb short stature (HP:0008921)3.23271337
27Cervical subluxation (HP:0003308)3.20542080
28Shallow orbits (HP:0000586)3.20256053
29Mitral valve prolapse (HP:0001634)3.17202614
30Fragile skin (HP:0001030)3.15889908
31Spinal rigidity (HP:0003306)3.14103242
32Type 1 muscle fiber predominance (HP:0003803)3.13481089
33Broad metatarsal (HP:0001783)3.03578915
34Spondylolisthesis (HP:0003302)3.03061328
35Genu recurvatum (HP:0002816)3.02942068
36Cerebral aneurysm (HP:0004944)3.02016544
37Myokymia (HP:0002411)2.96101884
38Aplasia involving bones of the upper limbs (HP:0009823)2.93488739
39Aplasia of the phalanges of the hand (HP:0009802)2.93488739
40Aplasia involving bones of the extremities (HP:0009825)2.93488739
41Overgrowth (HP:0001548)2.89714138
42Increased variability in muscle fiber diameter (HP:0003557)2.85870879
43Visual hallucinations (HP:0002367)2.83636488
44Abnormality of dentin (HP:0010299)2.82235722
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.81360445
46Osteolytic defects of the hand bones (HP:0009699)2.81360445
47Lip pit (HP:0100267)2.81063900
48Abnormal respiratory motile cilium morphology (HP:0005938)2.80575670
49Abnormal respiratory epithelium morphology (HP:0012253)2.80575670
50Broad-based gait (HP:0002136)2.78042321
51Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.77706658
52Poor eye contact (HP:0000817)2.76921978
53Aneurysm (HP:0002617)2.76804485
54Aortic regurgitation (HP:0001659)2.74501354
55Peritonitis (HP:0002586)2.74283901
56Mitral regurgitation (HP:0001653)2.71809261
57Atonic seizures (HP:0010819)2.71498229
58Abnormality of binocular vision (HP:0011514)2.57941371
59Diplopia (HP:0000651)2.57941371
60Joint laxity (HP:0001388)2.57705373
61Wide anterior fontanel (HP:0000260)2.54622622
62Blue sclerae (HP:0000592)2.51004124
63Lower limb amyotrophy (HP:0007210)2.48633603
64Biconcave vertebral bodies (HP:0004586)2.46217129
65Vertebral compression fractures (HP:0002953)2.45583633
66Mildly elevated creatine phosphokinase (HP:0008180)2.44321856
67Hyperkalemia (HP:0002153)2.40292319
68Abnormality of skeletal muscle fiber size (HP:0012084)2.39683377
69Hypoplasia of the iris (HP:0007676)2.39509039
70Slender build (HP:0001533)2.37967316
71Hyperextensible skin (HP:0000974)2.37864857
72Impaired social interactions (HP:0000735)2.37012741
73Abnormal social behavior (HP:0012433)2.37012741
74Status epilepticus (HP:0002133)2.35711957
75Gaze-evoked nystagmus (HP:0000640)2.34246758
76Absent speech (HP:0001344)2.33379724
77Absence seizures (HP:0002121)2.31566821
78Tubulointerstitial nephritis (HP:0001970)2.31463728
79Spinal cord lesions (HP:0100561)2.29420723
80Syringomyelia (HP:0003396)2.29420723
81Papilledema (HP:0001085)2.28454285
82Dialeptic seizures (HP:0011146)2.25929058
83Ulnar bowing (HP:0003031)2.24331211
84Aplasia cutis congenita (HP:0001057)2.23816418
85Mitral stenosis (HP:0001718)2.22271764
86Action tremor (HP:0002345)2.21957196
87Increased connective tissue (HP:0009025)2.21448324
88Fibular hypoplasia (HP:0003038)2.20642916
89Bowel diverticulosis (HP:0005222)2.19305628
90Hemiplegia (HP:0002301)2.19150579
91Drooling (HP:0002307)2.18329565
92Excessive salivation (HP:0003781)2.18329565
93Genetic anticipation (HP:0003743)2.11606329
94Osteomalacia (HP:0002749)2.11032380
95Hypoventilation (HP:0002791)2.08703798
96Rhinitis (HP:0012384)2.07428220
97Poikilocytosis (HP:0004447)2.07107543
98Mild short stature (HP:0003502)2.06429360
99Morphological abnormality of the middle ear (HP:0008609)2.05747308
100Dysdiadochokinesis (HP:0002075)2.05402228
101Elbow flexion contracture (HP:0002987)2.04363496
102Urinary bladder sphincter dysfunction (HP:0002839)2.04132839
103Progressive inability to walk (HP:0002505)2.02455695
104Absent frontal sinuses (HP:0002688)1.99915098
105Coronal craniosynostosis (HP:0004440)1.99803363
106Nasolacrimal duct obstruction (HP:0000579)1.98642310
107Dysmetria (HP:0001310)1.97798702
108Sensory axonal neuropathy (HP:0003390)1.97649162
109Short nail (HP:0001799)1.97624755
110Vertebral arch anomaly (HP:0008438)1.96937753
111Striae distensae (HP:0001065)1.96868041
112Ectopia lentis (HP:0001083)1.95862090
113Ankle clonus (HP:0011448)1.95584150
114Hyperthyroidism (HP:0000836)1.95279225
115Disproportionate tall stature (HP:0001519)1.95096040
116Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.93464671
117Abnormality of the acetabulum (HP:0003170)1.91880676
118Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.91305885
119Abnormality of the nasal septum (HP:0000419)1.90176439
120Aortic valve stenosis (HP:0001650)1.89961334
121Anxiety (HP:0000739)1.88140143
122Hyperventilation (HP:0002883)1.87813017
123Protruding tongue (HP:0010808)1.86981634
124Widely spaced teeth (HP:0000687)1.86976874
125Exotropia (HP:0000577)1.86818623
126Abnormality of calcium-phosphate metabolism (HP:0100530)1.86750323
127Supranuclear gaze palsy (HP:0000605)1.86584105
128Obstructive sleep apnea (HP:0002870)1.85860848
129Abnormality of salivation (HP:0100755)1.84867825
130Truncal ataxia (HP:0002078)1.84346980
131Overfolded helix (HP:0000396)1.84259089
132Heterotopia (HP:0002282)1.83291621
133Hyporeflexia of lower limbs (HP:0002600)1.82665106
134Bradycardia (HP:0001662)1.81130877
135Depression (HP:0000716)1.79900293
136Abnormal delivery (HP:0001787)1.78911247
137Pulmonary artery stenosis (HP:0004415)1.78644709
138Broad face (HP:0000283)1.78526876
139Camptodactyly of toe (HP:0001836)1.78239607
140Bulbous nose (HP:0000414)1.77714333
141Tetraparesis (HP:0002273)1.76452534
142Atelectasis (HP:0100750)1.76440722
143Upper limb amyotrophy (HP:0009129)1.76396701
144Distal upper limb amyotrophy (HP:0007149)1.76396701
145Abnormality of the renal medulla (HP:0100957)1.76283628
146Impaired vibration sensation in the lower limbs (HP:0002166)1.76009634
147Natal tooth (HP:0000695)1.75574114
148Broad ribs (HP:0000885)1.75266972
149Relative macrocephaly (HP:0004482)1.74851984
150Agitation (HP:0000713)1.74769088
151Abnormally folded helix (HP:0008544)1.74476308
152Distal lower limb amyotrophy (HP:0008944)1.74211668
153Limited hip movement (HP:0008800)1.74159780
154Severe Myopia (HP:0011003)1.73373326
155Abnormality of skull ossification (HP:0002703)1.72819894
156Asymmetry of the thorax (HP:0001555)1.72493041
157Persistence of primary teeth (HP:0006335)1.71811984
158Clumsiness (HP:0002312)1.71518677
159Inability to walk (HP:0002540)1.70406039
160Amblyopia (HP:0000646)1.70308027
161White forelock (HP:0002211)1.69988261
162Gastroesophageal reflux (HP:0002020)1.69975213
163Knee flexion contracture (HP:0006380)1.69797828
164Joint stiffness (HP:0001387)1.68405437
165Abnormality of the lacrimal duct (HP:0011481)1.68363051
166Wrist flexion contracture (HP:0001239)1.68305461
167Septo-optic dysplasia (HP:0100842)1.68107232
168Osteoarthritis (HP:0002758)1.66841578
169Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66184273
170Generalized myoclonic seizures (HP:0002123)1.66116682
171Deeply set eye (HP:0000490)1.65713707
172Narrow palate (HP:0000189)1.65501732
173Atrial fibrillation (HP:0005110)1.63058530
174Epileptiform EEG discharges (HP:0011182)1.63025997
175Steppage gait (HP:0003376)1.62964360
176Stereotypic behavior (HP:0000733)1.61920940
177Inguinal hernia (HP:0000023)1.61428286
178Abnormality of incisor morphology (HP:0011063)1.60973490
179Short clavicles (HP:0000894)1.60631433
180Abnormal ossification of hand bones (HP:0005921)1.60263224
181Venous abnormality (HP:0002624)1.60071049
182Postural instability (HP:0002172)1.59169668
183Mesomelia (HP:0003027)1.58787163
184Ventricular tachycardia (HP:0004756)1.58736225
185Decreased skull ossification (HP:0004331)1.57801235
186Abnormality of the heme biosynthetic pathway (HP:0010472)1.57722908
187Reduced subcutaneous adipose tissue (HP:0003758)1.57623099
188EEG with generalized epileptiform discharges (HP:0011198)1.57258886
189Neurofibrillary tangles (HP:0002185)1.57139397
190Tibial bowing (HP:0002982)1.57002636
191Delayed closure of the anterior fontanelle (HP:0001476)1.56646440
192Dislocated radial head (HP:0003083)1.55454125
193Broad long bones (HP:0005622)1.55044554
194Lipoatrophy (HP:0100578)1.54221426
195Coxa vara (HP:0002812)1.53788724
196Abnormality of carpal bone ossification (HP:0006257)1.53412816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.99901908
2MYLK3.88436754
3PDGFRA3.32062368
4CASK3.28151109
5TNIK3.23871999
6TTN2.91269130
7EPHA42.71391682
8NEK92.62647273
9DDR22.56952208
10RIPK12.43318416
11CAMK1G2.38318643
12RIPK42.30651060
13AKT32.27329510
14TRPM72.09003707
15PNCK2.07938106
16SIK22.03976431
17NTRK21.97631431
18BLK1.93407109
19LATS11.88531701
20TRIB31.88344592
21MARK11.83682408
22TGFBR21.81018167
23LATS21.75169098
24MAP2K71.74493532
25DAPK21.71081088
26MAP3K41.69256954
27INSRR1.69136473
28PDGFRB1.66514480
29PKN21.66156555
30EPHB11.58177573
31FES1.52704247
32CAMK1D1.52168022
33MAPK131.51877308
34GRK71.50264801
35DMPK1.44693050
36EPHB21.42812131
37PAK61.42130004
38MAP3K91.41516569
39* PTK21.41071585
40MKNK21.32568532
41MARK21.32454861
42FLT31.32182356
43JAK11.31992503
44NTRK11.27959141
45CAMK11.26892929
46CDK51.25759428
47MAP3K131.24622329
48GRK51.23090655
49MINK11.22904100
50MOS1.22446106
51PIK3CG1.21695970
52MET1.18803493
53TAOK31.18356347
54PKN11.16315315
55ICK1.15189773
56STK111.08606978
57SIK11.08084998
58TNK21.05738018
59MAPK71.04781532
60NEK61.00506642
61WNK10.99980033
62CDC42BPA0.99861777
63STK38L0.99375980
64SGK10.99180221
65ERN10.98507817
66MTOR0.98055581
67MAPKAPK50.95986368
68CDK120.95687781
69UHMK10.95200942
70FGR0.94710571
71MAP2K40.93384001
72MUSK0.92995377
73CDK30.92820295
74PRKD30.92518823
75PTK2B0.92241983
76MAP3K20.91383381
77ZAP700.91323846
78PRKD20.88385234
79CAMK2A0.88009606
80KSR20.86702811
81FGFR30.86649195
82FER0.86236787
83PHKG10.85905232
84PHKG20.85905232
85PIK3CA0.85855311
86EPHA30.84724660
87ADRBK20.83665829
88EEF2K0.82598008
89PRPF4B0.82117339
90PRKAA20.81833274
91LIMK10.81412990
92OXSR10.79813666
93CDK190.79724617
94FGFR40.79657443
95LMTK20.78458087
96MAP2K30.76814664
97DYRK1A0.75879317
98TESK10.75259082
99CAMKK10.74862083
100MAP3K120.73353924
101STK390.72996997
102MAP3K70.72488684
103STK380.72423618
104MELK0.70408556
105PAK30.69759401
106MAP3K30.69527036
107SGK20.68745257
108PRKCE0.68085918
109BMPR20.67988365
110PDPK10.67960408
111PRKD10.67638550
112KIT0.67313038
113SGK2230.65358558
114SGK4940.65358558
115TAOK10.62525989
116ROCK20.61727708
117PLK20.61505881
118GSK3A0.60712665
119MAP2K10.60294420
120PRKG10.59205231
121TYRO30.59165589
122PRKCG0.57546772
123FYN0.57126442
124SGK30.56890146
125CSNK1G20.56659643
126PRKCH0.55760224
127CDK60.55586751
128ADRBK10.55081623
129CAMK2B0.54930158
130PAK20.54776049
131PDK10.54274451
132HIPK20.53910061
133RPS6KA30.53772979
134RPS6KA20.53157597
135PAK40.52954694
136IRAK20.51132696
137KSR10.49766743
138FGFR20.49756012
139NLK0.49551043
140GRK10.49437614
141ROCK10.49259140
142MAPK100.49092275
143RET0.49080147
144JAK30.48930127
145MAP3K10.48050110
146PTK60.48029146
147TIE10.46961561
148MAPK120.45088294
149MAP3K60.44296646
150CAMK40.44251811
151PRKCQ0.43955114
152CAMKK20.43337354
153RPS6KL10.42515918
154RPS6KC10.42515918
155MST1R0.41528955
156DAPK10.41050147
157MAPKAPK30.40762941
158MAPK40.39160569
159TYK20.39148958
160STK240.38318612
161ILK0.36782615
162STK100.36635969
163RAF10.35519842

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.02347085
2Glutamatergic synapse_Homo sapiens_hsa047242.20267180
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.18848014
4Circadian entrainment_Homo sapiens_hsa047132.15139952
5Morphine addiction_Homo sapiens_hsa050322.12014950
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.03230027
7Olfactory transduction_Homo sapiens_hsa047402.01594263
8GABAergic synapse_Homo sapiens_hsa047271.93798227
9* Salivary secretion_Homo sapiens_hsa049701.91454434
10Amphetamine addiction_Homo sapiens_hsa050311.90417662
11Renin secretion_Homo sapiens_hsa049241.90330491
12Long-term potentiation_Homo sapiens_hsa047201.88180952
13Taste transduction_Homo sapiens_hsa047421.85692597
14Gastric acid secretion_Homo sapiens_hsa049711.85195088
15Synaptic vesicle cycle_Homo sapiens_hsa047211.74679837
16Amoebiasis_Homo sapiens_hsa051461.73382562
17Serotonergic synapse_Homo sapiens_hsa047261.72206609
18Adherens junction_Homo sapiens_hsa045201.68339216
19Proteoglycans in cancer_Homo sapiens_hsa052051.67193124
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.64570547
21Oxytocin signaling pathway_Homo sapiens_hsa049211.62953361
22* Calcium signaling pathway_Homo sapiens_hsa040201.60806284
23Insulin secretion_Homo sapiens_hsa049111.60717161
24Long-term depression_Homo sapiens_hsa047301.57315913
25Cholinergic synapse_Homo sapiens_hsa047251.56042838
26Dopaminergic synapse_Homo sapiens_hsa047281.53775296
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.52485376
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46004298
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44712067
30Cocaine addiction_Homo sapiens_hsa050301.43716386
31Protein digestion and absorption_Homo sapiens_hsa049741.42073758
32Axon guidance_Homo sapiens_hsa043601.37739094
33* cAMP signaling pathway_Homo sapiens_hsa040241.36169693
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.32115902
35Chronic myeloid leukemia_Homo sapiens_hsa052201.30146557
36* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29671259
37Phototransduction_Homo sapiens_hsa047441.29338472
38GnRH signaling pathway_Homo sapiens_hsa049121.26309619
39Small cell lung cancer_Homo sapiens_hsa052221.25531171
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23357717
41Dorso-ventral axis formation_Homo sapiens_hsa043201.23102535
42Type II diabetes mellitus_Homo sapiens_hsa049301.22975057
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.21582178
44Collecting duct acid secretion_Homo sapiens_hsa049661.21137806
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.18012002
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15445698
47Gap junction_Homo sapiens_hsa045401.13565010
48* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12208705
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11092689
50MicroRNAs in cancer_Homo sapiens_hsa052061.10072241
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09000361
52PI3K-Akt signaling pathway_Homo sapiens_hsa041511.08912140
53Pancreatic cancer_Homo sapiens_hsa052121.07808845
54Endometrial cancer_Homo sapiens_hsa052131.06243035
55Melanogenesis_Homo sapiens_hsa049161.05834859
56Dilated cardiomyopathy_Homo sapiens_hsa054141.03266973
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99982562
58ErbB signaling pathway_Homo sapiens_hsa040120.98671677
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98636150
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97191853
61Pathways in cancer_Homo sapiens_hsa052000.97009309
62Prion diseases_Homo sapiens_hsa050200.95792116
63Estrogen signaling pathway_Homo sapiens_hsa049150.95450665
64Non-small cell lung cancer_Homo sapiens_hsa052230.95258571
65Malaria_Homo sapiens_hsa051440.95151119
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92669755
67Autoimmune thyroid disease_Homo sapiens_hsa053200.91584101
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91518265
69mTOR signaling pathway_Homo sapiens_hsa041500.90409625
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.89926206
71Hippo signaling pathway_Homo sapiens_hsa043900.88671427
72Choline metabolism in cancer_Homo sapiens_hsa052310.86327672
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85775466
74Hedgehog signaling pathway_Homo sapiens_hsa043400.84843180
75Glioma_Homo sapiens_hsa052140.83712959
76MAPK signaling pathway_Homo sapiens_hsa040100.83618419
77Ras signaling pathway_Homo sapiens_hsa040140.83227960
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82328044
79Prostate cancer_Homo sapiens_hsa052150.82082605
80Acute myeloid leukemia_Homo sapiens_hsa052210.81875627
81Basal cell carcinoma_Homo sapiens_hsa052170.81061824
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.80925102
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80392842
84Tight junction_Homo sapiens_hsa045300.80350342
85Notch signaling pathway_Homo sapiens_hsa043300.80106407
86Ovarian steroidogenesis_Homo sapiens_hsa049130.79795824
87* Pancreatic secretion_Homo sapiens_hsa049720.79058573
88Prolactin signaling pathway_Homo sapiens_hsa049170.77903943
89TGF-beta signaling pathway_Homo sapiens_hsa043500.77676595
90Sphingolipid metabolism_Homo sapiens_hsa006000.77437418
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76677575
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.75781030
93Wnt signaling pathway_Homo sapiens_hsa043100.75179297
94Platelet activation_Homo sapiens_hsa046110.74801458
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73486866
96Endocytosis_Homo sapiens_hsa041440.72201331
97Bladder cancer_Homo sapiens_hsa052190.72119968
98Rap1 signaling pathway_Homo sapiens_hsa040150.71862582
99Thyroid cancer_Homo sapiens_hsa052160.71476191
100Colorectal cancer_Homo sapiens_hsa052100.70590624
101Insulin signaling pathway_Homo sapiens_hsa049100.68636179
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66910169
103Circadian rhythm_Homo sapiens_hsa047100.66771784
104Inositol phosphate metabolism_Homo sapiens_hsa005620.64002467
105FoxO signaling pathway_Homo sapiens_hsa040680.63740990
106Cardiac muscle contraction_Homo sapiens_hsa042600.63557781
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63042116
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62969835
109Toxoplasmosis_Homo sapiens_hsa051450.61588487
110AMPK signaling pathway_Homo sapiens_hsa041520.61345386
111Melanoma_Homo sapiens_hsa052180.60132422
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60017283
113Insulin resistance_Homo sapiens_hsa049310.59498649
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59290443
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58984984
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57981937
117Thyroid hormone synthesis_Homo sapiens_hsa049180.57789129
118ECM-receptor interaction_Homo sapiens_hsa045120.57402553
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57104553
120African trypanosomiasis_Homo sapiens_hsa051430.54261412
121Glucagon signaling pathway_Homo sapiens_hsa049220.54169853
122Renal cell carcinoma_Homo sapiens_hsa052110.53548567
123Chemokine signaling pathway_Homo sapiens_hsa040620.52795563
124VEGF signaling pathway_Homo sapiens_hsa043700.52037725
125Allograft rejection_Homo sapiens_hsa053300.51262025
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49256053
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49193773
128Fatty acid biosynthesis_Homo sapiens_hsa000610.47990709
129Focal adhesion_Homo sapiens_hsa045100.47483683
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46881992
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46075307
132ABC transporters_Homo sapiens_hsa020100.45642740
133Graft-versus-host disease_Homo sapiens_hsa053320.45541022
134Ether lipid metabolism_Homo sapiens_hsa005650.45008363
135Type I diabetes mellitus_Homo sapiens_hsa049400.43162629
136Rheumatoid arthritis_Homo sapiens_hsa053230.41835474
137Alcoholism_Homo sapiens_hsa050340.41207719
138T cell receptor signaling pathway_Homo sapiens_hsa046600.40672757
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.40382878
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39745709
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.39136612
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38927162

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »