ATP4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1digestion (GO:0007586)9.66081955
2tongue development (GO:0043586)9.26097983
3potassium ion export (GO:0071435)9.20700418
4epithelial structure maintenance (GO:0010669)8.50260747
5neutrophil mediated immunity (GO:0002446)7.70054282
6lung secretory cell differentiation (GO:0061140)7.42140272
7cobalamin metabolic process (GO:0009235)6.91125941
8regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)6.74488008
9phosphatidylserine acyl-chain remodeling (GO:0036150)6.71189592
10protein autoprocessing (GO:0016540)6.57702953
11leukotriene biosynthetic process (GO:0019370)6.52608775
12protein retention in ER lumen (GO:0006621)6.17292461
13sulfation (GO:0051923)6.07963884
14digestive system process (GO:0022600)6.06398723
15phosphatidylinositol acyl-chain remodeling (GO:0036149)6.04694137
16myeloid leukocyte mediated immunity (GO:0002444)6.03100774
17icosanoid secretion (GO:0032309)6.01635783
18arachidonic acid secretion (GO:0050482)6.01635783
19axon ensheathment in central nervous system (GO:0032291)5.99935576
20central nervous system myelination (GO:0022010)5.99935576
21glutathione derivative metabolic process (GO:1901685)5.95749441
22glutathione derivative biosynthetic process (GO:1901687)5.95749441
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.89170652
24extracellular fibril organization (GO:0043206)5.86634942
25phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.75932333
26membrane repolarization (GO:0086009)5.71276380
27vitamin transport (GO:0051180)5.69825689
28purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.66595563
293-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.66595563
30growth hormone secretion (GO:0030252)5.59538503
31icosanoid transport (GO:0071715)5.50029203
32fatty acid derivative transport (GO:1901571)5.50029203
33antibacterial humoral response (GO:0019731)5.49303222
34chondrocyte proliferation (GO:0035988)5.36443863
35O-glycan processing (GO:0016266)5.31804529
36innate immune response in mucosa (GO:0002227)5.25902500
37regulation of transforming growth factor beta2 production (GO:0032909)5.25714166
38regulation of cardioblast differentiation (GO:0051890)5.23780407
39antimicrobial humoral response (GO:0019730)5.16435022
40extracellular matrix assembly (GO:0085029)5.09761921
41phosphatidylserine metabolic process (GO:0006658)5.08720714
42leukotriene metabolic process (GO:0006691)5.04526317
43positive regulation of growth hormone secretion (GO:0060124)5.00737069
44myelin maintenance (GO:0043217)4.92091252
45fibril organization (GO:0097435)4.91961324
46valine metabolic process (GO:0006573)4.91517254
47calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.89760714
48phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.81344237
49regulation of transforming growth factor beta1 production (GO:0032908)4.75957172
50lung vasculature development (GO:0060426)4.49382453
51lung epithelial cell differentiation (GO:0060487)4.45759018
52sulfate transmembrane transport (GO:1902358)4.40232554
53lung cell differentiation (GO:0060479)4.38733471
54outflow tract septum morphogenesis (GO:0003148)4.36996186
55thyroid hormone metabolic process (GO:0042403)4.36364442
56acid secretion (GO:0046717)4.35304546
57diacylglycerol metabolic process (GO:0046339)4.34236999
58tetrapyrrole metabolic process (GO:0033013)4.32808382
59mucosal immune response (GO:0002385)4.32118520
60thyroid hormone generation (GO:0006590)4.30582904
61response to BMP (GO:0071772)4.27029268
62cellular response to BMP stimulus (GO:0071773)4.27029268
63peptidyl-proline hydroxylation (GO:0019511)4.22584677
64alditol phosphate metabolic process (GO:0052646)4.17465866
65ethanol oxidation (GO:0006069)4.16400603
66branched-chain amino acid catabolic process (GO:0009083)4.16244509
67somite development (GO:0061053)4.15639796
68negative regulation of interleukin-1 beta production (GO:0032691)4.13462580
69keratan sulfate catabolic process (GO:0042340)4.08491424
70embryonic foregut morphogenesis (GO:0048617)4.06726479
71organ or tissue specific immune response (GO:0002251)4.06257027
72phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.03302974
73potassium ion import (GO:0010107)4.01704119
74branched-chain amino acid metabolic process (GO:0009081)3.94548923
75lung epithelium development (GO:0060428)3.94546164
76protein O-linked glycosylation (GO:0006493)3.92678877
77embryonic camera-type eye morphogenesis (GO:0048596)3.89657463
78lysine metabolic process (GO:0006553)3.89439118
79lysine catabolic process (GO:0006554)3.89439118
80negative regulation of interleukin-1 production (GO:0032692)3.85185629
81regulation of glucocorticoid secretion (GO:2000849)3.83474363
82tight junction assembly (GO:0070830)3.77893125
83negative regulation of digestive system process (GO:0060457)3.73847208
84adult feeding behavior (GO:0008343)3.72838980
85positive regulation of neurological system process (GO:0031646)3.72319751
86regulation of membrane repolarization (GO:0060306)3.72133618
87regulation of heart rate by cardiac conduction (GO:0086091)3.69021254
88phosphatidylcholine acyl-chain remodeling (GO:0036151)3.68508407
89sulfate transport (GO:0008272)3.57567352
90bundle of His cell to Purkinje myocyte communication (GO:0086069)3.56908429
91mesenchymal cell differentiation involved in kidney development (GO:0072161)3.56631004
92mesenchymal cell differentiation involved in renal system development (GO:2001012)3.56631004
93atrioventricular valve morphogenesis (GO:0003181)3.55233185
94regulation of growth hormone secretion (GO:0060123)3.53119675
95endocrine hormone secretion (GO:0060986)3.53047158
96respiratory tube development (GO:0030323)3.52434488
97basement membrane organization (GO:0071711)3.51066081
98sulfur amino acid catabolic process (GO:0000098)3.51052396
99cardiac muscle adaptation (GO:0014887)3.50772380
100cardiac muscle hypertrophy in response to stress (GO:0014898)3.50772380
101muscle hypertrophy in response to stress (GO:0003299)3.50772380
102phospholipid scrambling (GO:0017121)3.42748214
103organ formation (GO:0048645)3.38910469
104response to iron ion (GO:0010039)3.37535119
105endocardial cushion development (GO:0003197)3.33897809
106protein hydroxylation (GO:0018126)3.33413918
107skeletal muscle organ development (GO:0060538)3.33326930
108phosphatidic acid metabolic process (GO:0046473)3.30926359
109phosphatidic acid biosynthetic process (GO:0006654)3.30926359
110bicarbonate transport (GO:0015701)3.29330335
111embryonic digestive tract morphogenesis (GO:0048557)3.29102871
112smooth muscle tissue development (GO:0048745)3.27121968
113glutathione metabolic process (GO:0006749)3.26858004
114xenobiotic metabolic process (GO:0006805)3.26727935
115membrane repolarization during action potential (GO:0086011)3.25833754
116diaphragm development (GO:0060539)3.24919165
117COPI coating of Golgi vesicle (GO:0048205)3.18986547
118Golgi transport vesicle coating (GO:0048200)3.18986547
119cardiac conduction (GO:0061337)3.18252183
120fucose catabolic process (GO:0019317)3.17923614
121L-fucose metabolic process (GO:0042354)3.17923614
122L-fucose catabolic process (GO:0042355)3.17923614
123positive regulation of chemokine secretion (GO:0090197)3.17046222
124epithelial cell-cell adhesion (GO:0090136)3.14013049
125ventricular cardiac muscle cell action potential (GO:0086005)3.13020922
126cellular ketone body metabolic process (GO:0046950)3.12991161
127glycerol metabolic process (GO:0006071)3.12714208
128regulation of corticosteroid hormone secretion (GO:2000846)3.12177973
129cell differentiation involved in metanephros development (GO:0072202)3.11627636
130glandular epithelial cell differentiation (GO:0002067)3.10885455
131sodium ion export (GO:0071436)3.10762975
132* regulation of pH (GO:0006885)3.07920019
133purine nucleoside bisphosphate metabolic process (GO:0034032)3.07265105
134ribonucleoside bisphosphate metabolic process (GO:0033875)3.07265105
135nucleoside bisphosphate metabolic process (GO:0033865)3.07265105
136positive regulation of pseudopodium assembly (GO:0031274)3.05111780
137cell proliferation involved in kidney development (GO:0072111)3.03621922
138white fat cell differentiation (GO:0050872)2.99911052
139establishment of apical/basal cell polarity (GO:0035089)2.98485599
140phosphatidylglycerol metabolic process (GO:0046471)2.98004048
141* hydrogen ion transmembrane transport (GO:1902600)2.97709265
142positive regulation of steroid hormone secretion (GO:2000833)2.94786002
143drug transmembrane transport (GO:0006855)2.93887910
144type B pancreatic cell proliferation (GO:0044342)2.92469260
145cellular response to epinephrine stimulus (GO:0071872)2.91491272
146heart morphogenesis (GO:0003007)2.89688860
147short-chain fatty acid metabolic process (GO:0046459)2.89502240
148alditol metabolic process (GO:0019400)2.88580046
149positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.85020112
150long-chain fatty acid transport (GO:0015909)2.84428909
151ethanol metabolic process (GO:0006067)2.84063183
152triglyceride metabolic process (GO:0006641)2.82621268
153acylglycerol metabolic process (GO:0006639)2.79879926
154regulation of cardiac muscle cell apoptotic process (GO:0010665)2.79022858
155negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.78979037
156cellular response to gonadotropin stimulus (GO:0071371)2.77197667
157tricarboxylic acid metabolic process (GO:0072350)2.76334605
158cardiac muscle cell action potential involved in contraction (GO:0086002)2.75475401
159neutral lipid metabolic process (GO:0006638)2.74788729
160intestinal absorption (GO:0050892)2.74733401
1612-oxoglutarate metabolic process (GO:0006103)2.74280415
162dicarboxylic acid metabolic process (GO:0043648)2.73757761
163aspartate family amino acid catabolic process (GO:0009068)2.73636541
164embryonic eye morphogenesis (GO:0048048)2.73279584
165cardiac muscle cell action potential (GO:0086001)2.72421230
166regulation of chemokine secretion (GO:0090196)2.72277691
167regulation of pseudopodium assembly (GO:0031272)2.69801498
168membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.68439034
169water-soluble vitamin metabolic process (GO:0006767)2.65905182
170cardiac muscle hypertrophy (GO:0003300)2.65168169
171negative regulation of transcription by competitive promoter binding (GO:0010944)2.64826421
172negative regulation of T cell differentiation in thymus (GO:0033085)2.64387945
173smooth muscle cell differentiation (GO:0051145)2.63052473
174negative regulation of fatty acid transport (GO:2000192)2.62848551
175neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.62643456
176striated muscle hypertrophy (GO:0014897)2.61021459
177maternal placenta development (GO:0001893)2.57220437
178negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.56224981
179phosphatidylinositol phosphorylation (GO:0046854)2.55100321
180regulation of interleukin-13 production (GO:0032656)2.52958626
181renal system development (GO:0072001)2.52092024
182regulation of phospholipase A2 activity (GO:0032429)11.2465678
183maintenance of gastrointestinal epithelium (GO:0030277)11.2163348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX2_27498859_Chip-Seq_STOMACH_Mouse5.43285557
2ESR1_15608294_ChIP-ChIP_MCF-7_Human4.64926802
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.34294405
4EGR1_19032775_ChIP-ChIP_M12_Human4.00459496
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.99248051
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.78630105
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.56911836
8SRY_22984422_ChIP-ChIP_TESTIS_Rat3.39328079
9STAT6_21828071_ChIP-Seq_BEAS2B_Human3.38764002
10ESR1_21235772_ChIP-Seq_MCF-7_Human3.34862119
11ESR2_21235772_ChIP-Seq_MCF-7_Human3.17626928
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.01951468
13GATA4_25053715_ChIP-Seq_YYC3_Human2.93910465
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.92895484
15EZH2_22144423_ChIP-Seq_EOC_Human2.89573683
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.87487111
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.85141904
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.85141904
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.85141904
20HTT_18923047_ChIP-ChIP_STHdh_Human2.57070928
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.53306424
22* LXR_22158963_ChIP-Seq_LIVER_Mouse2.39002083
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.37612907
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.36442693
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.21783314
26GATA6_25053715_ChIP-Seq_YYC3_Human2.19328832
27PPAR_26484153_Chip-Seq_NCI-H1993_Human2.18698476
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99697569
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99697569
30SOX2_20726797_ChIP-Seq_SW620_Human1.97966945
31ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.93792956
32* LXR_22292898_ChIP-Seq_THP-1_Human1.92335305
33ISL1_27105846_Chip-Seq_CPCs_Mouse1.88298807
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82303576
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.81653873
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.81652361
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.81476736
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.80868320
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76180941
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.72085855
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69848730
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69118579
43VDR_22108803_ChIP-Seq_LS180_Human1.67846111
44AHR_22903824_ChIP-Seq_MCF-7_Human1.67471330
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.67021428
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66826977
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66163812
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.64351616
49AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.63829922
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.60172775
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.58458870
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.57459803
53GATA3_24758297_ChIP-Seq_MCF-7_Human1.56850074
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52033164
55ELK4_26923725_Chip-Seq_MESODERM_Mouse1.51795936
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.48929672
57STAT1_20625510_ChIP-Seq_HELA_Human1.48664413
58CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.46737504
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.44959766
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44863071
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43416414
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38867118
63CLOCK_20551151_ChIP-Seq_293T_Human1.38326913
64RACK7_27058665_Chip-Seq_MCF-7_Human1.37141579
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36851384
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35296700
67GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.33339593
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32850109
69ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30928126
70SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29596050
71BCOR_27268052_Chip-Seq_Bcells_Human1.29257416
72* EZH2_27294783_Chip-Seq_ESCs_Mouse1.29014799
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28481243
74FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.26775910
75EP300_21415370_ChIP-Seq_HL-1_Mouse1.26214780
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25987704
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25524473
78TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.25354683
79* KLF5_25053715_ChIP-Seq_YYC3_Human1.25176088
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24790062
81BCAT_22108803_ChIP-Seq_LS180_Human1.24279740
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23894894
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.23183808
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21271493
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20938309
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19141642
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18593174
88KAP1_22055183_ChIP-Seq_ESCs_Mouse1.17993461
89SOX2_16153702_ChIP-ChIP_HESCs_Human1.16940571
90GATA1_26923725_Chip-Seq_HPCs_Mouse1.16927070
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16473609
92RUNX1_27514584_Chip-Seq_MCF-7_Human1.16122474
93FOXA1_25552417_ChIP-Seq_VCAP_Human1.14019649
94CDX2_20551321_ChIP-Seq_CACO-2_Human1.11511938
95DROSHA_22980978_ChIP-Seq_HELA_Human1.11510724
96P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11065703
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10284360
98RNF2_27304074_Chip-Seq_NSC_Mouse1.09032413
99EGR1_19374776_ChIP-ChIP_THP-1_Human1.08676611
100MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08560716
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.08516504
102BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08423410
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08024076
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07784212
105FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06901288
106ZNF274_21170338_ChIP-Seq_K562_Hela1.06026115
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05373011
108CREB1_26743006_Chip-Seq_LNCaP_Human1.05030781
109ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04966891
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03435267
111JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02878313
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01843447
113GATA1_22025678_ChIP-Seq_K562_Human1.01621835
114SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01333652
115TBX20_22328084_ChIP-Seq_HEART_Mouse0.99816699
116TBX20_22080862_ChIP-Seq_HEART_Mouse0.99816699
117ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98460852
118RING1B_27294783_Chip-Seq_ESCs_Mouse0.98030676
119WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97909739
120TP53_20018659_ChIP-ChIP_R1E_Mouse0.97849978
121PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95831957
122KDM2B_26808549_Chip-Seq_K562_Human0.95411631
123ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95231751
124KDM2B_26808549_Chip-Seq_REH_Human0.95133474
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94944806
126SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93725973
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93715556
128MYC_19829295_ChIP-Seq_ESCs_Human0.92987399
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92809856
130CTCF_27219007_Chip-Seq_Bcells_Human0.92773401
131RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91686645
132SA1_27219007_Chip-Seq_ERYTHROID_Human0.91177155
133GATA1_19941826_ChIP-Seq_K562_Human0.91152349
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.90969009
135PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90819927
136SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90509254
137* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90401170
138DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89890345
139* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89558754
140TRIM28_21343339_ChIP-Seq_HEK293_Human0.89504464
141ATF3_27146783_Chip-Seq_COLON_Human0.89272283
142HNF4A_19822575_ChIP-Seq_HepG2_Human0.89208983
143SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89046572
144SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88542578
145ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88276450
146YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87518478
147EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86835366
148SA1_22415368_ChIP-Seq_MEFs_Mouse0.86547066
149RXR_22108803_ChIP-Seq_LS180_Human0.85750575
150CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84835010
151NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84254452
152FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.83798594
153EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83461103
154SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82733136
155PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81329254
156P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.80770622
157SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79072947
158ZNF263_19887448_ChIP-Seq_K562_Human0.78866429
159PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78438821
160GATA2_21666600_ChIP-Seq_HMVEC_Human0.77806124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption4.28326200
2* MP0001664_abnormal_digestion3.83346431
3MP0001873_stomach_inflammation3.58058497
4* MP0000470_abnormal_stomach_morphology3.34980610
5MP0003806_abnormal_nucleotide_metabolis3.27045569
6MP0003868_abnormal_feces_composition2.81658656
7MP0005083_abnormal_biliary_tract2.55906660
8MP0008004_abnormal_stomach_pH16.9711991
9MP0005085_abnormal_gallbladder_physiolo1.90847754
10MP0005275_abnormal_skin_tensile1.80758450
11MP0004043_abnormal_pH_regulation1.67104218
12MP0008438_abnormal_cutaneous_collagen1.56995909
13MP0002139_abnormal_hepatobiliary_system1.55198356
14MP0005365_abnormal_bile_salt1.53327398
15MP0005165_increased_susceptibility_to1.48501489
16MP0008875_abnormal_xenobiotic_pharmacok1.47646573
17MP0010234_abnormal_vibrissa_follicle1.44545645
18MP0001663_abnormal_digestive_system1.43050382
19MP0005360_urolithiasis1.36813654
20MP0005381_digestive/alimentary_phenotyp1.34885046
21MP0005503_abnormal_tendon_morphology1.34857023
22MP0010329_abnormal_lipoprotein_level1.34557966
23MP0000566_synostosis1.31161047
24MP0004264_abnormal_extraembryonic_tissu1.29889653
25MP0002909_abnormal_adrenal_gland1.28832043
26MP0006054_spinal_hemorrhage1.17864017
27MP0003283_abnormal_digestive_organ1.12899737
28MP0003186_abnormal_redox_activity1.02964530
29MP0009643_abnormal_urine_homeostasis0.94148953
30MP0002118_abnormal_lipid_homeostasis0.92049777
31MP0002837_dystrophic_cardiac_calcinosis0.90573856
32MP0005332_abnormal_amino_acid0.90003397
33MP0000462_abnormal_digestive_system0.89608854
34MP0003195_calcinosis0.89049748
35MP0001756_abnormal_urination0.88012094
36MP0004019_abnormal_vitamin_homeostasis0.86554147
37MP0001958_emphysema0.85526584
38MP0005266_abnormal_metabolism0.80926713
39MP0002876_abnormal_thyroid_physiology0.77227343
40MP0003252_abnormal_bile_duct0.76678420
41MP0001765_abnormal_ion_homeostasis0.76056220
42MP0002078_abnormal_glucose_homeostasis0.73336997
43MP0009780_abnormal_chondrocyte_physiolo0.71546917
44MP0005636_abnormal_mineral_homeostasis0.69788557
45MP0002138_abnormal_hepatobiliary_system0.69667954
46MP0009384_cardiac_valve_regurgitation0.69496369
47MP0000013_abnormal_adipose_tissue0.68463478
48MP0005220_abnormal_exocrine_pancreas0.65537979
49* MP0003953_abnormal_hormone_level0.64716060
50MP0004858_abnormal_nervous_system0.62043269
51MP0002970_abnormal_white_adipose0.62010656
52MP0005452_abnormal_adipose_tissue0.59478201
53MP0003191_abnormal_cellular_cholesterol0.59387314
54MP0004272_abnormal_basement_membrane0.59022108
55MP0002693_abnormal_pancreas_physiology0.58845989
56MP0002877_abnormal_melanocyte_morpholog0.57072088
57MP0000467_abnormal_esophagus_morphology0.55966953
58MP0003705_abnormal_hypodermis_morpholog0.55777244
59* MP0000477_abnormal_intestine_morphology0.55652533
60MP0005670_abnormal_white_adipose0.55626381
61MP0005319_abnormal_enzyme/_coenzyme0.55484661
62MP0000537_abnormal_urethra_morphology0.54287683
63MP0004185_abnormal_adipocyte_glucose0.52858162
64MP0003075_altered_response_to0.52735786
65MP0001944_abnormal_pancreas_morphology0.51678861
66MP0005584_abnormal_enzyme/coenzyme_acti0.51342481
67MP0010386_abnormal_urinary_bladder0.51316261
68MP0008961_abnormal_basal_metabolism0.49733157
69MP0005334_abnormal_fat_pad0.49391219
70MP0000534_abnormal_ureter_morphology0.49033885
71MP0003943_abnormal_hepatobiliary_system0.48518549
72MP0000751_myopathy0.47489581
73MP0000490_abnormal_crypts_of0.47482233
74* MP0009642_abnormal_blood_homeostasis0.47340511
75MP0002136_abnormal_kidney_physiology0.47218336
76MP0002108_abnormal_muscle_morphology0.44027483
77MP0005310_abnormal_salivary_gland0.43637874
78MP0010368_abnormal_lymphatic_system0.43114319
79MP0005508_abnormal_skeleton_morphology0.42622678
80MP0004484_altered_response_of0.42341433
81MP0000767_abnormal_smooth_muscle0.42226171
82MP0002796_impaired_skin_barrier0.40902704
83MP0000609_abnormal_liver_physiology0.40356563
84MP0005367_renal/urinary_system_phenotyp0.40193258
85MP0000516_abnormal_urinary_system0.40193258
86MP0000538_abnormal_urinary_bladder0.40160437
87MP0002127_abnormal_cardiovascular_syste0.40072092
88MP0003119_abnormal_digestive_system0.39255943
89MP0003329_amyloid_beta_deposits0.39097248
90MP0000598_abnormal_liver_morphology0.38956474
91MP0005058_abnormal_lysosome_morphology0.37901734
92MP0001485_abnormal_pinna_reflex0.37863441
93MP0005376_homeostasis/metabolism_phenot0.36452356
94MP0003115_abnormal_respiratory_system0.36047731
95MP0004134_abnormal_chest_morphology0.35626975
96MP0005408_hypopigmentation0.34819181
97MP0000762_abnormal_tongue_morphology0.34645661
98MP0002069_abnormal_eating/drinking_beha0.34564191
99MP0001849_ear_inflammation0.34419911
100MP0004130_abnormal_muscle_cell0.34396791
101MP0006036_abnormal_mitochondrial_physio0.33676359
102MP0005166_decreased_susceptibility_to0.33438947
103MP0001243_abnormal_dermal_layer0.33212539
104MP0005257_abnormal_intraocular_pressure0.32264093
105MP0004215_abnormal_myocardial_fiber0.31306537
106MP0000049_abnormal_middle_ear0.31285365
107MP0005409_darkened_coat_color0.31196131
108MP0001879_abnormal_lymphatic_vessel0.31167506
109MP0003942_abnormal_urinary_system0.30838369
110MP0002009_preneoplasia0.30248560
111MP0003866_abnormal_defecation0.29920635
112MP0003137_abnormal_impulse_conducting0.29657580
113MP0009703_decreased_birth_body0.29464707
114MP0002896_abnormal_bone_mineralization0.29370113
115MP0010155_abnormal_intestine_physiology0.29051967
116MP0009672_abnormal_birth_weight0.29049365
117MP0000367_abnormal_coat/_hair0.28025626
118MP0000733_abnormal_muscle_development0.27032745
119MP0004885_abnormal_endolymph0.27019402
120MP0000003_abnormal_adipose_tissue0.26884089
121MP0009840_abnormal_foam_cell0.26675761
122MP0003638_abnormal_response/metabolism_0.26464994
123MP0002249_abnormal_larynx_morphology0.26305151
124MP0005666_abnormal_adipose_tissue0.25939411
125MP0006138_congestive_heart_failure0.25119322
126MP0003172_abnormal_lysosome_physiology0.25063858
127MP0003656_abnormal_erythrocyte_physiolo0.24859571
128MP0010630_abnormal_cardiac_muscle0.24693844
129MP0003300_gastrointestinal_ulcer0.24605075
130MP0005620_abnormal_muscle_contractility0.24592829
131MP0003566_abnormal_cell_adhesion0.24455728
132MP0003959_abnormal_lean_body0.24399991
133MP0004947_skin_inflammation0.24071502
134MP0002060_abnormal_skin_morphology0.22698515
135MP0004197_abnormal_fetal_growth/weight/0.22666248
136MP0005595_abnormal_vascular_smooth0.21851863
137MP0005330_cardiomyopathy0.21632564
138MP0003315_abnormal_perineum_morphology0.21628703
139MP0009250_abnormal_appendicular_skeleto0.21354649
140MP0008469_abnormal_protein_level0.21348710
141MP0005535_abnormal_body_temperature0.21251482
142MP0003937_abnormal_limbs/digits/tail_de0.20534955
143MP0000230_abnormal_systemic_arterial0.20284931
144MP0000266_abnormal_heart_morphology0.20250364
145MP0005375_adipose_tissue_phenotype0.20051771
146MP0002925_abnormal_cardiovascular_devel0.20032310
147MP0005084_abnormal_gallbladder_morpholo0.19997894
148MP0000604_amyloidosis0.19797066
149MP0010030_abnormal_orbit_morphology0.19630715
150MP0002932_abnormal_joint_morphology0.19547405
151MP0001270_distended_abdomen0.19028610
152MP0003122_maternal_imprinting0.18274435
153MP0003279_aneurysm0.18240510
154MP0001299_abnormal_eye_distance/0.18072817
155MP0003935_abnormal_craniofacial_develop0.17884812
156MP0002751_abnormal_autonomic_nervous0.17609371
157MP0001614_abnormal_blood_vessel0.17106355
158MP0009931_abnormal_skin_appearance0.16587697
159MP0000428_abnormal_craniofacial_morphol0.16486382
160MP0002933_joint_inflammation0.15868981
161MP0002697_abnormal_eye_size0.15586227
162MP0000163_abnormal_cartilage_morphology0.15396841
163MP0002116_abnormal_craniofacial_bone0.15237460
164MP0000432_abnormal_head_morphology0.15146316
165MP0003941_abnormal_skin_development0.15031018
166MP0005369_muscle_phenotype0.14885801
167MP0004087_abnormal_muscle_fiber0.14731142
168MP0002089_abnormal_postnatal_growth/wei0.14254240
169MP0002938_white_spotting0.13976790

Predicted human phenotypes

RankGene SetZ-score
1Megaloblastic anemia (HP:0001889)8.31584149
2Abnormality of the vitamin B12 metabolism (HP:0004341)8.01549866
3Abnormality of vitamin B metabolism (HP:0004340)7.65588773
4Abnormality of vitamin metabolism (HP:0100508)6.26152054
5Gout (HP:0001997)6.25691497
6Ketoacidosis (HP:0001993)4.14720207
7Right ventricular cardiomyopathy (HP:0011663)4.00859094
8Hyperuricemia (HP:0002149)3.74408251
9Increased purine levels (HP:0004368)3.74408251
10Abnormality of the aortic arch (HP:0012303)3.59932018
11Ketosis (HP:0001946)3.51289441
12Renal salt wasting (HP:0000127)3.44630403
13Abnormal pancreas size (HP:0012094)3.43956808
14Goiter (HP:0000853)3.40378675
15Abnormality of purine metabolism (HP:0004352)3.31880824
16Macrocytic anemia (HP:0001972)3.28762793
17Hypoglycemic coma (HP:0001325)3.23082159
18Hyperactive renin-angiotensin system (HP:0000841)3.12028473
19Patent foramen ovale (HP:0001655)3.08454844
20Ventricular fibrillation (HP:0001663)2.99698265
21Increased circulating renin level (HP:0000848)2.96163785
22Hyperglycinuria (HP:0003108)2.89321491
23Abnormality of renal excretion (HP:0011036)2.71477231
24Abnormality of chloride homeostasis (HP:0011422)2.66987602
25Generalized aminoaciduria (HP:0002909)2.59824747
26Paresthesia (HP:0003401)2.59656232
27Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.57476129
28Short 4th metacarpal (HP:0010044)2.57476129
29Malnutrition (HP:0004395)2.56817392
30Abnormality of fatty-acid metabolism (HP:0004359)2.55979351
31Hypokalemic alkalosis (HP:0001949)2.55078857
32Intrahepatic cholestasis (HP:0001406)2.54130637
33Syncope (HP:0001279)2.45759024
34Abnormality of serine family amino acid metabolism (HP:0010894)2.44991502
35Abnormality of glycine metabolism (HP:0010895)2.44991502
36Double outlet right ventricle (HP:0001719)2.44439936
37Congenital malformation of the right heart (HP:0011723)2.44439936
38Tubulointerstitial fibrosis (HP:0005576)2.42871368
39Cerebral aneurysm (HP:0004944)2.37694832
40Abnormality of aromatic amino acid family metabolism (HP:0004338)2.37312493
41Abnormal umbilical cord blood vessels (HP:0011403)2.35661215
42Single umbilical artery (HP:0001195)2.35661215
43Abnormality of the fetal cardiovascular system (HP:0010948)2.35661215
44Rectal prolapse (HP:0002035)2.34158936
45Abnormality of the middle phalanges of the toes (HP:0010183)2.26570820
46Glomerulosclerosis (HP:0000096)2.26326459
47Hyperammonemia (HP:0001987)2.25823226
48Proximal tubulopathy (HP:0000114)2.24210842
49Hyperglycinemia (HP:0002154)2.22703553
50Tubulointerstitial nephritis (HP:0001970)2.22094511
51Annular pancreas (HP:0001734)2.18592026
52Palpitations (HP:0001962)2.18373855
53Abnormality of nucleobase metabolism (HP:0010932)2.17241908
54Neonatal short-limb short stature (HP:0008921)2.16981004
55Hypoglycemic seizures (HP:0002173)2.16790988
56Hypomagnesemia (HP:0002917)2.16233872
57Abnormality of renin-angiotensin system (HP:0000847)2.09756625
58Abnormality of monocarboxylic acid metabolism (HP:0010996)2.09390293
59Neoplasm of the heart (HP:0100544)2.08848459
60Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.08369248
61Metabolic alkalosis (HP:0200114)2.06291658
62Hyperinsulinemic hypoglycemia (HP:0000825)2.05844226
63Lethargy (HP:0001254)2.04973230
64Bladder diverticulum (HP:0000015)2.00433511
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00010188
66Abnormal number of erythroid precursors (HP:0012131)15.4156808
67Abnormality of cells of the erythroid lineage (HP:0012130)13.8194544
68Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.96877777
69Tubular atrophy (HP:0000092)1.96474473
70Hyperglycemia (HP:0003074)1.94386921
71Abnormality of the distal phalanx of the thumb (HP:0009617)1.93860766
72Late onset (HP:0003584)1.93368873
73Symptomatic seizures (HP:0011145)1.91925049
74Vacuolated lymphocytes (HP:0001922)1.91858720
75Polyuria (HP:0000103)1.89272995
76Abnormality of magnesium homeostasis (HP:0004921)1.88989394
77Aplasia involving bones of the extremities (HP:0009825)1.88788080
78Aplasia involving bones of the upper limbs (HP:0009823)1.88788080
79Aplasia of the phalanges of the hand (HP:0009802)1.88788080
80Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.86230646
81Hyperparathyroidism (HP:0000843)1.85841159
82Abnormal urine output (HP:0012590)1.85340453
83Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85178307
84Dicarboxylic aciduria (HP:0003215)1.85178307
85Sensorimotor neuropathy (HP:0007141)1.85083748
86Glycosuria (HP:0003076)1.79170077
87Abnormality of urine glucose concentration (HP:0011016)1.79170077
88Abnormality of the renal cortex (HP:0011035)1.79109185
89Hyperaldosteronism (HP:0000859)1.78931052
90Abnormality of the 4th metacarpal (HP:0010012)1.78319516
91Abnormality of the proximal phalanges of the hand (HP:0009834)1.77903377
92Hypotension (HP:0002615)1.77237421
93Pancreatitis (HP:0001733)1.76319366
94Cupped ribs (HP:0000887)1.76286798
95Broad palm (HP:0001169)1.76254238
96Aortic regurgitation (HP:0001659)1.75913440
97Deep venous thrombosis (HP:0002625)1.75744612
98Mucopolysacchariduria (HP:0008155)1.74939691
99Urinary glycosaminoglycan excretion (HP:0003541)1.74939691
100Vascular calcification (HP:0004934)1.73413469
101Pheochromocytoma (HP:0002666)1.72959904
102Abnormality of the phalanges of the hallux (HP:0010057)1.71743441
103Metabolic acidosis (HP:0001942)1.71566617
104Abnormality of the 2nd finger (HP:0004100)1.71321267
105Bronchomalacia (HP:0002780)1.70955953
106Vomiting (HP:0002013)1.70237872
107Lymphangioma (HP:0100764)1.69848849
108Pulmonary artery stenosis (HP:0004415)1.66589294
109Xanthomatosis (HP:0000991)1.66266065
110Aneurysm (HP:0002617)1.65793699
111Dysostosis multiplex (HP:0000943)1.64649945
112Abnormal drinking behavior (HP:0030082)1.63771429
113Polydipsia (HP:0001959)1.63771429
114Conjunctival hamartoma (HP:0100780)1.63131274
115Juvenile onset (HP:0003621)1.62544487
116Alkalosis (HP:0001948)1.59680114
117Abnormality of permanent molar morphology (HP:0011071)1.58790834
118Abnormality of the dental root (HP:0006486)1.58790834
119Taurodontia (HP:0000679)1.58790834
120Aortic dissection (HP:0002647)1.58649355
121Conjugated hyperbilirubinemia (HP:0002908)1.56366573
122Ventricular arrhythmia (HP:0004308)1.56335858
123Premature rupture of membranes (HP:0001788)1.55451365
124Abnormality of glutamine family amino acid metabolism (HP:0010902)1.55178826
125Truncus arteriosus (HP:0001660)1.54205321
126Back pain (HP:0003418)1.54173280
127Cardiovascular calcification (HP:0011915)1.54161301
128Relative macrocephaly (HP:0004482)1.54088506
129Abdominal situs inversus (HP:0003363)1.53293658
130Abnormality of abdominal situs (HP:0011620)1.53293658
131Prolonged QT interval (HP:0001657)1.51918760
132Hypokalemia (HP:0002900)1.51695177
133Cardiomegaly (HP:0001640)1.51591667
134Short tibia (HP:0005736)1.51351469
135Infantile muscular hypotonia (HP:0008947)1.50960433
136Abnormality of molar morphology (HP:0011070)1.50475461
137Abnormality of molar (HP:0011077)1.50475461
138Flared iliac wings (HP:0002869)1.49474119
139Thin bony cortex (HP:0002753)1.49023188
140Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.48048260
141Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.47453887
142Abnormality of mucopolysaccharide metabolism (HP:0011020)1.46806919
143Abnormality of polysaccharide metabolism (HP:0011012)1.46806919
144Abnormality of glycosaminoglycan metabolism (HP:0004371)1.46806919
145Short phalanx of the thumb (HP:0009660)1.45565158
146Aortic aneurysm (HP:0004942)1.42311990
147Spastic diplegia (HP:0001264)1.42290615
148Distal lower limb amyotrophy (HP:0008944)1.42168976
149Transposition of the great arteries (HP:0001669)1.41671893
150Abnormal connection of the cardiac segments (HP:0011545)1.41671893
151Abnormal ventriculo-arterial connection (HP:0011563)1.41671893
152Broad face (HP:0000283)1.41225048
153Abnormal tarsal ossification (HP:0008369)1.41130363
154Cervical subluxation (HP:0003308)1.40632018
155Abnormal ossification of hand bones (HP:0005921)1.39978135
156Abnormality of the dental pulp (HP:0006479)1.38037146
157Abnormality of the umbilical cord (HP:0010881)1.36564456
158Visceral angiomatosis (HP:0100761)1.35592506
159Aplasia/Hypoplasia of the tibia (HP:0005772)1.35143107
160Hemorrhage of the eye (HP:0011885)1.31046433
161Short humerus (HP:0005792)1.30479047
162Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.30321894
163Abnormal hand bone ossification (HP:0010660)1.28410439
164Germ cell neoplasia (HP:0100728)1.27212638
165Abnormal EKG (HP:0003115)1.26794130
166Broad forehead (HP:0000337)1.24867206
167Short femoral neck (HP:0100864)1.23332142
168Abnormality of the epiphyses of the hand (HP:0005924)1.22554878
169Protrusio acetabuli (HP:0003179)1.21369240
170Dilatation of the ascending aorta (HP:0005111)1.20890755
171Preauricular pit (HP:0004467)1.20866543
172Periauricular skin pits (HP:0100277)1.20866543
173Turricephaly (HP:0000262)1.20835235
174Hemangiomatosis (HP:0007461)1.20606319
175Renovascular hypertension (HP:0100817)1.19837407
176Atrophic scars (HP:0001075)1.18284930
177Mitral valve prolapse (HP:0001634)1.17031165
178Cutaneous finger syndactyly (HP:0010554)1.16874437
179Aplasia/hypoplasia of the humerus (HP:0006507)1.16274214
180Soft skin (HP:0000977)1.15407478
181Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.15057298

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.05719679
2MST1R4.77993324
3BCKDK4.71480469
4WNK44.56034725
5MAPK154.00024686
6TRIB33.80657927
7MYLK3.11242340
8ERBB42.72428021
9STK392.69409257
10LRRK22.65647702
11OXSR12.51972286
12PIK3CG2.48106361
13PKN22.43706116
14MAP3K22.22305593
15ERN12.20565016
16KSR22.17618844
17MET2.05594580
18WNK32.00143271
19PTK61.84295772
20LATS11.72619915
21INSRR1.66567997
22RIPK41.59714988
23PAK31.59365935
24SMG11.49801895
25MAP3K101.46900785
26STK101.41414031
27MAP2K21.35356831
28FGFR41.35008037
29ZAP701.32958863
30CDK191.25743954
31PDK21.22725281
32PRKCI1.21420502
33DMPK1.19999069
34PDGFRB1.18703243
35LMTK21.17642146
36FGFR31.09475171
37ROCK21.05010764
38BRD41.04758579
39MAP2K11.03820763
40FER1.02994394
41NEK10.96995192
42NUAK10.96561992
43TIE10.96451596
44FRK0.95382257
45PDK40.91356617
46PDK30.91356617
47NME10.91107193
48TESK10.90416866
49RPS6KA20.89317129
50MAP3K90.88104390
51PDPK10.85453700
52TYRO30.84107472
53NTRK10.80270812
54PTK20.78804647
55SCYL20.77572124
56CDC42BPA0.76582461
57WNK10.76522725
58PRKG20.75181609
59ROCK10.74282344
60NTRK30.74278856
61CDK30.73963498
62EPHB10.72632244
63TTN0.67253605
64ICK0.65919865
65PAK40.65819282
66PAK20.64399451
67STK110.63055591
68PDK10.61852254
69CDK120.61592635
70GRK70.60450141
71EEF2K0.58439518
72MAP3K80.56325698
73LATS20.55108950
74VRK10.54755869
75RET0.54677321
76PRKD30.54635201
77MTOR0.54431699
78SGK4940.53973634
79SGK2230.53973634
80GRK60.53916712
81JAK20.53443519
82STK38L0.53269583
83FGFR10.49554040
84CASK0.48434539
85FLT30.47449152
86FYN0.46230968
87DYRK1B0.45605117
88TAOK30.45589449
89CAMK1D0.45038164
90DDR20.45031903
91KDR0.44967003
92NEK20.44495013
93EPHB20.44107573
94PDGFRA0.41677242
95EGFR0.41054344
96MAPK70.39556695
97NME20.39538891
98RPS6KL10.39304015
99RPS6KC10.39304015
100AKT20.39027703
101MAP3K30.38655962
102SGK30.37341534
103PAK60.35985652
104NLK0.35743362
105PRKAA20.34637891
106MATK0.34276677
107SGK20.33942387
108MAP2K60.32565961
109MAPK10.32547987
110AKT30.32242776
111ILK0.32157902
112DAPK20.31887643
113HIPK20.31813482
114NEK90.31793288
115MAPK30.31138604
116EPHA30.30874801
117FGFR20.29339425
118LIMK10.28330967
119RIPK10.27743937
120SRC0.27686399
121MAPKAPK50.27436871
122TGFBR20.27403735
123MAPK40.27028307
124KSR10.26763891
125GSK3A0.26718949
126CAMK40.26512350
127MELK0.25859436
128RPS6KA60.25746533
129DAPK30.24350798
130CAMK10.23935732
131MARK20.23742835
132MINK10.23629935
133CDK90.22441033
134PRKAA10.22372678
135STK30.22343512
136PIK3CA0.22326970
137AKT10.21767042
138RAF10.21493469
139PRKD10.21126038
140RPS6KA10.20540043
141SIK10.20523745
142PAK10.19684943
143CSK0.19638965
144PRKD20.19389739
145STK380.18751962
146CAMKK10.18730396
147GSK3B0.18701259
148PHKG10.18606735
149PHKG20.18606735
150MAP3K10.18356246
151IGF1R0.18036237
152MAPKAPK30.17989171
153CDK50.17795638
154ERBB20.16994832
155RPS6KB20.16984253

Predicted pathways (KEGG)

RankGene SetZ-score
1* Collecting duct acid secretion_Homo sapiens_hsa049664.61443392
2Fat digestion and absorption_Homo sapiens_hsa049754.28645438
3Vitamin digestion and absorption_Homo sapiens_hsa049774.18564834
4* Gastric acid secretion_Homo sapiens_hsa049713.72888336
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.62215519
6Sulfur metabolism_Homo sapiens_hsa009203.35148798
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.30764817
8Linoleic acid metabolism_Homo sapiens_hsa005913.03844582
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.92262436
10Chemical carcinogenesis_Homo sapiens_hsa052042.51040861
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39889483
12Glutathione metabolism_Homo sapiens_hsa004802.26184229
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.08183824
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.98279795
15Fatty acid degradation_Homo sapiens_hsa000711.94378352
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.93695493
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90508319
18Propanoate metabolism_Homo sapiens_hsa006401.85537036
19Ether lipid metabolism_Homo sapiens_hsa005651.82711678
20Pancreatic secretion_Homo sapiens_hsa049721.73383560
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.67834974
22Nitrogen metabolism_Homo sapiens_hsa009101.54287542
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44526303
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43348140
25Butanoate metabolism_Homo sapiens_hsa006501.41725294
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39451863
27* Oxidative phosphorylation_Homo sapiens_hsa001901.22054610
28Arachidonic acid metabolism_Homo sapiens_hsa005901.17836176
29Glycerolipid metabolism_Homo sapiens_hsa005611.17567043
30Bile secretion_Homo sapiens_hsa049761.16970900
31Pyruvate metabolism_Homo sapiens_hsa006201.09469655
32Thyroid hormone synthesis_Homo sapiens_hsa049181.09273201
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06504297
34beta-Alanine metabolism_Homo sapiens_hsa004101.03715248
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03330455
36Phenylalanine metabolism_Homo sapiens_hsa003601.02745763
37Tryptophan metabolism_Homo sapiens_hsa003801.01527514
38Histidine metabolism_Homo sapiens_hsa003400.98120393
39Hedgehog signaling pathway_Homo sapiens_hsa043400.97503917
40Fatty acid metabolism_Homo sapiens_hsa012120.97448575
41Retinol metabolism_Homo sapiens_hsa008300.93192584
42Carbon metabolism_Homo sapiens_hsa012000.92044328
43Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86524886
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.85552884
45ECM-receptor interaction_Homo sapiens_hsa045120.85494404
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83702481
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83573231
48Peroxisome_Homo sapiens_hsa041460.78132895
49Focal adhesion_Homo sapiens_hsa045100.75779925
50Notch signaling pathway_Homo sapiens_hsa043300.74688044
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74350173
52Glycerophospholipid metabolism_Homo sapiens_hsa005640.72966011
53Arginine biosynthesis_Homo sapiens_hsa002200.72073608
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69625878
55Inositol phosphate metabolism_Homo sapiens_hsa005620.68146651
56Tyrosine metabolism_Homo sapiens_hsa003500.67767658
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.66577898
58Selenocompound metabolism_Homo sapiens_hsa004500.65953502
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.63029105
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61901705
61Adherens junction_Homo sapiens_hsa045200.60596031
62PPAR signaling pathway_Homo sapiens_hsa033200.59535041
63Other glycan degradation_Homo sapiens_hsa005110.59477986
64Hepatitis C_Homo sapiens_hsa051600.57427361
65Basal cell carcinoma_Homo sapiens_hsa052170.57382476
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57273835
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56800511
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55411961
69Lysosome_Homo sapiens_hsa041420.54011943
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52950857
71Mineral absorption_Homo sapiens_hsa049780.51769686
72Cocaine addiction_Homo sapiens_hsa050300.51511502
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51492874
74Chronic myeloid leukemia_Homo sapiens_hsa052200.49062912
75Biosynthesis of amino acids_Homo sapiens_hsa012300.48599445
76Vibrio cholerae infection_Homo sapiens_hsa051100.47956217
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.47851846
78Fatty acid biosynthesis_Homo sapiens_hsa000610.47533068
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44805564
80Insulin secretion_Homo sapiens_hsa049110.44421850
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42765855
82Choline metabolism in cancer_Homo sapiens_hsa052310.42195702
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.41743693
84Cholinergic synapse_Homo sapiens_hsa047250.40909804
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40032913
86cAMP signaling pathway_Homo sapiens_hsa040240.39688395
87Protein export_Homo sapiens_hsa030600.39577826
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37823340
89Fatty acid elongation_Homo sapiens_hsa000620.36322886
90Amoebiasis_Homo sapiens_hsa051460.35497720
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35436590
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35079951
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34319070
94Renal cell carcinoma_Homo sapiens_hsa052110.33948440
95ErbB signaling pathway_Homo sapiens_hsa040120.33846692
96TGF-beta signaling pathway_Homo sapiens_hsa043500.32227456
97Starch and sucrose metabolism_Homo sapiens_hsa005000.31844484
98ABC transporters_Homo sapiens_hsa020100.31759703
99Rap1 signaling pathway_Homo sapiens_hsa040150.31239458
100Folate biosynthesis_Homo sapiens_hsa007900.30782177
101Amphetamine addiction_Homo sapiens_hsa050310.30640036
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29149095
103Taste transduction_Homo sapiens_hsa047420.28819153
104AMPK signaling pathway_Homo sapiens_hsa041520.28591667
105Melanogenesis_Homo sapiens_hsa049160.27846879
106Proteoglycans in cancer_Homo sapiens_hsa052050.27811268
107GnRH signaling pathway_Homo sapiens_hsa049120.27049850
108Gap junction_Homo sapiens_hsa045400.26682899
109Hippo signaling pathway_Homo sapiens_hsa043900.26147983
110Pathways in cancer_Homo sapiens_hsa052000.26130210
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.26087354
112Metabolic pathways_Homo sapiens_hsa011000.25166596
113Lysine degradation_Homo sapiens_hsa003100.25004696
114Fructose and mannose metabolism_Homo sapiens_hsa000510.24991347
115Calcium signaling pathway_Homo sapiens_hsa040200.24908660
116Endometrial cancer_Homo sapiens_hsa052130.24829513
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.24570947
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23988359
119Insulin signaling pathway_Homo sapiens_hsa049100.23710250
120Small cell lung cancer_Homo sapiens_hsa052220.23658507
121Galactose metabolism_Homo sapiens_hsa000520.23644916
122Axon guidance_Homo sapiens_hsa043600.23634010
123Circadian rhythm_Homo sapiens_hsa047100.23070553
124Salivary secretion_Homo sapiens_hsa049700.22593262
125Alzheimers disease_Homo sapiens_hsa050100.22211263
126Pentose phosphate pathway_Homo sapiens_hsa000300.22082569
127Cardiac muscle contraction_Homo sapiens_hsa042600.19542893
128Parkinsons disease_Homo sapiens_hsa050120.19480830
129Prostate cancer_Homo sapiens_hsa052150.19272556
130Renin secretion_Homo sapiens_hsa049240.18422807
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16607708
132Prolactin signaling pathway_Homo sapiens_hsa049170.16323949
133Platelet activation_Homo sapiens_hsa046110.16085646
134Sphingolipid metabolism_Homo sapiens_hsa006000.15994545
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.15551008
136mTOR signaling pathway_Homo sapiens_hsa041500.14629726
137Insulin resistance_Homo sapiens_hsa049310.14502596
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14491331
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.14192300
140Arginine and proline metabolism_Homo sapiens_hsa003300.13963867
141Colorectal cancer_Homo sapiens_hsa052100.13926171
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13311553
143Circadian entrainment_Homo sapiens_hsa047130.13164652
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13091948
145Tight junction_Homo sapiens_hsa045300.13043606
146Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12978058
147Melanoma_Homo sapiens_hsa052180.12962005
148Thyroid cancer_Homo sapiens_hsa052160.12588531
149Oxytocin signaling pathway_Homo sapiens_hsa049210.12326018
150Bladder cancer_Homo sapiens_hsa052190.11202261
151Glucagon signaling pathway_Homo sapiens_hsa049220.09059861
152Estrogen signaling pathway_Homo sapiens_hsa049150.08896063
153N-Glycan biosynthesis_Homo sapiens_hsa005100.03223264
154Adipocytokine signaling pathway_Homo sapiens_hsa049200.02673327
155cGMP-PKG signaling pathway_Homo sapiens_hsa040220.01688533
156Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.01487683
157Protein digestion and absorption_Homo sapiens_hsa049740.01466551
158Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.01362731
159Sulfur relay system_Homo sapiens_hsa041220.01292524

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