ATP4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1digestion (GO:0007586)9.90275081
2epithelial structure maintenance (GO:0010669)9.09122636
3neutrophil mediated immunity (GO:0002446)8.72522317
4potassium ion export (GO:0071435)8.60254830
5pH reduction (GO:0045851)8.10724861
6tongue development (GO:0043586)7.90978527
7phosphatidylserine acyl-chain remodeling (GO:0036150)7.35853775
8lung secretory cell differentiation (GO:0061140)7.18742803
9leukotriene biosynthetic process (GO:0019370)7.05853231
10cobalamin metabolic process (GO:0009235)7.00926371
11arachidonic acid secretion (GO:0050482)6.99051654
12icosanoid secretion (GO:0032309)6.99051654
13myeloid leukocyte mediated immunity (GO:0002444)6.80721287
14phosphatidylinositol acyl-chain remodeling (GO:0036149)6.75582652
15extracellular fibril organization (GO:0043206)6.54732344
16phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.47159705
17growth hormone secretion (GO:0030252)6.38360578
18icosanoid transport (GO:0071715)6.27850098
19fatty acid derivative transport (GO:1901571)6.27850098
20protein autoprocessing (GO:0016540)6.24781322
21digestive system process (GO:0022600)6.19724424
22sulfation (GO:0051923)6.13510945
23regulation of pH (GO:0006885)5.93057543
24protein retention in ER lumen (GO:0006621)5.75794714
25regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.75089506
26antibacterial humoral response (GO:0019731)5.74441107
27glutathione derivative biosynthetic process (GO:1901687)5.72448033
28glutathione derivative metabolic process (GO:1901685)5.72448033
29vitamin transport (GO:0051180)5.67158724
30leukotriene metabolic process (GO:0006691)5.65867838
31positive regulation of growth hormone secretion (GO:0060124)5.62963799
32innate immune response in mucosa (GO:0002227)5.57049343
33phosphatidylserine metabolic process (GO:0006658)5.56212099
34fibril organization (GO:0097435)5.53035294
35antimicrobial humoral response (GO:0019730)5.37305406
36O-glycan processing (GO:0016266)5.37128973
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.30044852
38energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)5.27700738
39ATP hydrolysis coupled proton transport (GO:0015991)5.27700738
40phosphatidylethanolamine acyl-chain remodeling (GO:0036152)5.21820024
41regulation of transforming growth factor beta2 production (GO:0032909)5.05815104
423-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.97396188
43purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.97396188
44acid secretion (GO:0046717)4.95834613
45chondrocyte proliferation (GO:0035988)4.89629497
46phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.86318849
47negative regulation of interleukin-1 beta production (GO:0032691)4.78442566
48regulation of cardioblast differentiation (GO:0051890)4.74097053
49membrane repolarization (GO:0086009)4.72453089
50peptidyl-proline hydroxylation (GO:0019511)4.69828864
51extracellular matrix assembly (GO:0085029)4.55276023
52central nervous system myelination (GO:0022010)4.54288182
53axon ensheathment in central nervous system (GO:0032291)4.54288182
54diacylglycerol metabolic process (GO:0046339)4.53396976
55alditol phosphate metabolic process (GO:0052646)4.49778022
56mucosal immune response (GO:0002385)4.48241202
57thyroid hormone metabolic process (GO:0042403)4.47939231
58negative regulation of interleukin-1 production (GO:0032692)4.42572826
59ATP biosynthetic process (GO:0006754)4.38812416
60thyroid hormone generation (GO:0006590)4.38033649
61calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.31357344
62embryonic foregut morphogenesis (GO:0048617)4.28669144
63lung epithelial cell differentiation (GO:0060487)4.27128345
64organ or tissue specific immune response (GO:0002251)4.23722731
65lung vasculature development (GO:0060426)4.20163368
66outflow tract septum morphogenesis (GO:0003148)4.19830200
67lung cell differentiation (GO:0060479)4.19602999
68regulation of growth hormone secretion (GO:0060123)4.09406880
69cellular response to BMP stimulus (GO:0071773)4.07967218
70response to BMP (GO:0071772)4.07967218
71phosphatidylcholine acyl-chain remodeling (GO:0036151)4.03966570
72respiratory tube development (GO:0030323)3.99214316
73ethanol oxidation (GO:0006069)3.97112566
74adult feeding behavior (GO:0008343)3.96385745
75protein O-linked glycosylation (GO:0006493)3.90266678
76keratan sulfate catabolic process (GO:0042340)3.89584134
77bundle of His cell to Purkinje myocyte communication (GO:0086069)3.89315920
78phosphatidic acid biosynthetic process (GO:0006654)3.85364832
79phosphatidic acid metabolic process (GO:0046473)3.85364832
80monovalent inorganic cation homeostasis (GO:0055067)3.84009322
81myelin maintenance (GO:0043217)3.81825027
82valine metabolic process (GO:0006573)3.72439104
83protein hydroxylation (GO:0018126)3.69447587
84somite development (GO:0061053)3.67998509
85sulfate transmembrane transport (GO:1902358)3.64354243
86endocrine hormone secretion (GO:0060986)3.62551730
87regulation of glucocorticoid secretion (GO:2000849)3.61165568
88ventricular cardiac muscle cell action potential (GO:0086005)3.61037439
89sequestering of extracellular ligand from receptor (GO:0035581)3.57592064
90tetrapyrrole metabolic process (GO:0033013)3.55000350
91embryonic camera-type eye morphogenesis (GO:0048596)3.47747994
92glandular epithelial cell differentiation (GO:0002067)3.46239759
93branched-chain amino acid catabolic process (GO:0009083)3.42636833
94tight junction assembly (GO:0070830)3.40611465
95endocardial cushion development (GO:0003197)3.40379514
96smooth muscle tissue development (GO:0048745)3.38652516
97lung epithelium development (GO:0060428)3.37616500
98phospholipid scrambling (GO:0017121)3.36683512
99purine nucleoside monophosphate biosynthetic process (GO:0009127)3.33106995
100purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.33106995
101organ formation (GO:0048645)3.30795416
102phosphatidylglycerol metabolic process (GO:0046471)3.30722886
103negative regulation of digestive system process (GO:0060457)3.29790051
104positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.23544698
105positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.20903830
106L-fucose catabolic process (GO:0042355)3.19467661
107fucose catabolic process (GO:0019317)3.19467661
108L-fucose metabolic process (GO:0042354)3.19467661
109regulation of membrane repolarization (GO:0060306)3.18304268
110heart morphogenesis (GO:0003007)3.18009558
111bicarbonate transport (GO:0015701)3.15863735
112purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.15857147
113sodium ion export (GO:0071436)3.15791252
114embryonic digestive tract morphogenesis (GO:0048557)3.15373098
115response to iron ion (GO:0010039)3.13561990
116embryonic retina morphogenesis in camera-type eye (GO:0060059)3.13253203
117long-chain fatty acid transport (GO:0015909)3.11888297
118potassium ion import (GO:0010107)3.11294078
119purine nucleoside triphosphate biosynthetic process (GO:0009145)3.10204715
120basement membrane organization (GO:0071711)3.09018040
121glycerol metabolic process (GO:0006071)3.08650369
122cell differentiation involved in metanephros development (GO:0072202)3.08130024
123mesenchymal cell differentiation involved in kidney development (GO:0072161)3.08061773
124mesenchymal cell differentiation involved in renal system development (GO:2001012)3.08061773
125positive regulation of neurological system process (GO:0031646)3.07659553
126atrioventricular valve morphogenesis (GO:0003181)3.06900975
127cellular response to gonadotropin stimulus (GO:0071371)3.06584457
128regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.05343194
129sulfate transport (GO:0008272)3.04500190
130intestinal epithelial cell development (GO:0060576)3.01347464
131icosanoid biosynthetic process (GO:0046456)3.00573826
132fatty acid derivative biosynthetic process (GO:1901570)3.00573826
133membrane repolarization during action potential (GO:0086011)3.00392404
134positive regulation of calcium ion transport into cytosol (GO:0010524)3.00296944
135branched-chain amino acid metabolic process (GO:0009081)2.98294895
136regulation of transforming growth factor beta1 production (GO:0032908)2.97910968
137xenobiotic metabolic process (GO:0006805)2.97081080
138cellular response to arsenic-containing substance (GO:0071243)2.92967223
139glomerulus development (GO:0032835)2.89370383
140regulation of cardiac muscle cell differentiation (GO:2000725)2.88695695
141extracellular negative regulation of signal transduction (GO:1900116)2.86637330
142extracellular regulation of signal transduction (GO:1900115)2.86637330
143regulation of corticosteroid hormone secretion (GO:2000846)2.86540728
144establishment of apical/basal cell polarity (GO:0035089)2.85125219
145positive regulation of steroid hormone secretion (GO:2000833)2.83954259
146sulfur amino acid catabolic process (GO:0000098)2.81047318
147alditol metabolic process (GO:0019400)2.80501570
148cell proliferation involved in kidney development (GO:0072111)2.80371606
149ribonucleoside triphosphate biosynthetic process (GO:0009201)2.80240569
150regulation of heart rate by cardiac conduction (GO:0086091)2.80001720
151regulation of skeletal muscle contraction (GO:0014819)2.79938340
152glutathione metabolic process (GO:0006749)2.79369719
153nucleoside triphosphate biosynthetic process (GO:0009142)2.79154581
154cardiac muscle hypertrophy in response to stress (GO:0014898)2.77775864
155muscle hypertrophy in response to stress (GO:0003299)2.77775864
156cardiac muscle adaptation (GO:0014887)2.77775864
157cardiac conduction (GO:0061337)2.76624973
158diaphragm development (GO:0060539)2.74044537
159epithelial cell-cell adhesion (GO:0090136)2.73217581
160skeletal muscle organ development (GO:0060538)2.68464201
161regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.67999619
162positive regulation of chemokine secretion (GO:0090197)2.67932385
163negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.67486824
164phosphatidylinositol phosphorylation (GO:0046854)2.66872499
165regulation of cardiac muscle cell apoptotic process (GO:0010665)2.60484500
166positive regulation of pseudopodium assembly (GO:0031274)2.59643203
167smooth muscle cell differentiation (GO:0051145)2.59119433
168ribonucleoside monophosphate biosynthetic process (GO:0009156)2.57189973
169negative regulation of T cell differentiation in thymus (GO:0033085)2.55996262
170type B pancreatic cell development (GO:0003323)2.55663447
171type B pancreatic cell proliferation (GO:0044342)2.52010265
172regulation of phospholipase A2 activity (GO:0032429)12.6224430
173regulation of proton transport (GO:0010155)12.1180487
174maintenance of gastrointestinal epithelium (GO:0030277)11.8946463

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human6.05839091
2ESR1_15608294_ChIP-ChIP_MCF-7_Human5.03011036
3SOX2_27498859_Chip-Seq_STOMACH_Mouse5.01794448
4EGR1_19032775_ChIP-ChIP_M12_Human4.20020191
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.10394554
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.61727425
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.53358530
8SRY_22984422_ChIP-ChIP_TESTIS_Rat3.47559106
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.32937942
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.32937942
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.32937942
12ESR2_21235772_ChIP-Seq_MCF-7_Human3.10641339
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.07573501
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.02947973
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.92551675
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79974666
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.74746690
18GATA4_25053715_ChIP-Seq_YYC3_Human2.71963287
19EZH2_22144423_ChIP-Seq_EOC_Human2.66018902
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.61668089
21HTT_18923047_ChIP-ChIP_STHdh_Human2.47067839
22PPAR_26484153_Chip-Seq_NCI-H1993_Human2.37668682
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.22525919
24LXR_22292898_ChIP-Seq_THP-1_Human1.97469120
25GATA6_25053715_ChIP-Seq_YYC3_Human1.97039613
26ISL1_27105846_Chip-Seq_CPCs_Mouse1.96492021
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.95818008
28PPARA_22158963_ChIP-Seq_LIVER_Mouse1.94295120
29SOX2_20726797_ChIP-Seq_SW620_Human1.87340781
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.86600903
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85247370
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85247370
33KLF5_25053715_ChIP-Seq_YYC3_Human1.81551631
34ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.81363316
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.81088529
36LXR_22158963_ChIP-Seq_LIVER_Mouse1.80848288
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.80479389
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.73841829
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.73267523
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73005333
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72502580
42VDR_22108803_ChIP-Seq_LS180_Human1.69187445
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.64038143
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62141362
45RNF2_27304074_Chip-Seq_NSC_Mouse1.60680676
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58931632
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57362615
48TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.55727276
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53766708
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52125028
51SMAD3_21741376_ChIP-Seq_HESCs_Human1.51163278
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47229790
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.45893510
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.44770347
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.44757458
56STAT1_20625510_ChIP-Seq_HELA_Human1.44237204
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42542972
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41397593
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.41150576
60GATA3_24758297_ChIP-Seq_MCF-7_Human1.40278422
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.40076606
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39836646
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.39452818
64ELK4_26923725_Chip-Seq_MESODERM_Mouse1.35963539
65GBX2_23144817_ChIP-Seq_PC3_Human1.35116298
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.34681258
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33820963
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.32775877
69SMAD4_21741376_ChIP-Seq_HESCs_Human1.32074807
70RACK7_27058665_Chip-Seq_MCF-7_Human1.24649568
71YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23902896
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23875961
73FOXA2_19822575_ChIP-Seq_HepG2_Human1.22986231
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.21228149
75SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21225007
76AR_21572438_ChIP-Seq_LNCaP_Human1.20881499
77RING1B_27294783_Chip-Seq_NPCs_Mouse1.20139899
78BCAT_22108803_ChIP-Seq_LS180_Human1.19129434
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19014068
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18367786
81BCOR_27268052_Chip-Seq_Bcells_Human1.18270366
82KDM2B_26808549_Chip-Seq_REH_Human1.17831318
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.17824024
84EGR1_19374776_ChIP-ChIP_THP-1_Human1.17122890
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16923017
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15327605
87JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13591220
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13520101
89* ARNT_22903824_ChIP-Seq_MCF-7_Human1.13273592
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12730222
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11432316
92RUNX1_27514584_Chip-Seq_MCF-7_Human1.11386192
93KDM2B_26808549_Chip-Seq_K562_Human1.10133293
94NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08653931
95NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08132014
96TRIM28_21343339_ChIP-Seq_HEK293_Human1.07819171
97SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07696509
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07647977
99MYC_19829295_ChIP-Seq_ESCs_Human1.06606137
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04543577
101* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04040123
102P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03772569
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03222113
104GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.02522143
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01814973
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01687847
107ZNF274_21170338_ChIP-Seq_K562_Hela1.01478921
108SOX2_16153702_ChIP-ChIP_HESCs_Human1.00979320
109CLOCK_20551151_ChIP-Seq_293T_Human1.00825958
110DROSHA_22980978_ChIP-Seq_HELA_Human1.00631295
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00518654
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00452399
113WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00434199
114ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00358986
115ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00211948
116SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00020824
117ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98585633
118TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98520143
119FUS_26573619_Chip-Seq_HEK293_Human0.97441305
120TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97412765
121ZNF263_19887448_ChIP-Seq_K562_Human0.97333077
122RXR_22108803_ChIP-Seq_LS180_Human0.95993969
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95282025
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95282025
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95179031
126* AHR_22903824_ChIP-Seq_MCF-7_Human0.94659168
127SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93683832
128NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93500063
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.93268705
130CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92764870
131NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92761606
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92761606
133CREB1_26743006_Chip-Seq_LNCaP_Human0.91734859
134STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91399488
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91077467
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.90800223
137CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90287008
138SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90241512
139MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90073614
140DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88405069
141GATA2_21666600_ChIP-Seq_HMVEC_Human0.88322353
142GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87026955
143TBX20_22328084_ChIP-Seq_HEART_Mouse0.85965896
144TBX20_22080862_ChIP-Seq_HEART_Mouse0.85965896
145ATF3_27146783_Chip-Seq_COLON_Human0.85942428
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85844846
147SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85682328
148TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.84559845
149SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84416765
150SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84416765
151CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84301657
152NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84296593
153BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82399921
154CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82137667
155CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82059012
156SA1_27219007_Chip-Seq_ERYTHROID_Human0.82057991
157PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78892724
158SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.78337267
159FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76734949
160P300_27058665_Chip-Seq_ZR-75-30cells_Human0.76493372
161SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.76216745
162FOXM1_26456572_ChIP-Seq_MCF-7_Human0.75231614
163NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.75061153
164FOXH1_21741376_ChIP-Seq_ESCs_Human0.74592872
165FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.73019671
166TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.72477459
167GATA1_19941826_ChIP-Seq_K562_Human0.72264340
168HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.72061400

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001664_abnormal_digestion7.68064942
2MP0001666_abnormal_nutrient_absorption6.38446254
3MP0001873_stomach_inflammation5.58857971
4* MP0000470_abnormal_stomach_morphology5.33254191
5MP0005275_abnormal_skin_tensile4.78198121
6MP0003806_abnormal_nucleotide_metabolis4.53671715
7MP0005083_abnormal_biliary_tract4.02878387
8MP0003868_abnormal_feces_composition4.00471389
9MP0005503_abnormal_tendon_morphology3.44824661
10MP0005085_abnormal_gallbladder_physiolo2.46108651
11MP0005165_increased_susceptibility_to2.34802116
12MP0001663_abnormal_digestive_system2.22969273
13MP0000566_synostosis2.19108524
14MP0010234_abnormal_vibrissa_follicle2.15961749
15MP0005381_digestive/alimentary_phenotyp2.01282036
16* MP0008004_abnormal_stomach_pH10.4769034
17MP0010329_abnormal_lipoprotein_level1.92194208
18MP0001958_emphysema1.70891626
19MP0002909_abnormal_adrenal_gland1.65324839
20MP0008875_abnormal_xenobiotic_pharmacok1.57916503
21MP0005365_abnormal_bile_salt1.55388148
22MP0004264_abnormal_extraembryonic_tissu1.48660546
23MP0004272_abnormal_basement_membrane1.46129520
24MP0006054_spinal_hemorrhage1.46040972
25MP0000534_abnormal_ureter_morphology1.42432360
26MP0000477_abnormal_intestine_morphology1.39978792
27MP0003705_abnormal_hypodermis_morpholog1.36491941
28MP0010368_abnormal_lymphatic_system1.29151185
29MP0005266_abnormal_metabolism1.25404296
30MP0003186_abnormal_redox_activity1.25187434
31MP0009384_cardiac_valve_regurgitation1.24369152
32MP0003943_abnormal_hepatobiliary_system1.22049144
33MP0002837_dystrophic_cardiac_calcinosis1.17448355
34MP0002118_abnormal_lipid_homeostasis1.17261030
35MP0005508_abnormal_skeleton_morphology1.12366334
36MP0003119_abnormal_digestive_system1.06728737
37MP0002108_abnormal_muscle_morphology1.05661398
38MP0000462_abnormal_digestive_system1.05348062
39MP0002139_abnormal_hepatobiliary_system1.03738891
40MP0000538_abnormal_urinary_bladder0.99219908
41MP0010386_abnormal_urinary_bladder0.98945176
42MP0005670_abnormal_white_adipose0.98941773
43MP0000516_abnormal_urinary_system0.98857256
44MP0005367_renal/urinary_system_phenotyp0.98857256
45MP0003283_abnormal_digestive_organ0.98080539
46MP0000467_abnormal_esophagus_morphology0.95750252
47MP0004185_abnormal_adipocyte_glucose0.95450935
48MP0004484_altered_response_of0.94805817
49MP0003890_abnormal_embryonic-extraembry0.94685272
50MP0003942_abnormal_urinary_system0.94344142
51MP0002970_abnormal_white_adipose0.93130208
52MP0000537_abnormal_urethra_morphology0.91988802
53MP0004134_abnormal_chest_morphology0.90247749
54MP0005452_abnormal_adipose_tissue0.89943660
55MP0000049_abnormal_middle_ear0.88670984
56MP0002249_abnormal_larynx_morphology0.88168105
57MP0003075_altered_response_to0.87842418
58MP0000767_abnormal_smooth_muscle0.86853108
59MP0002127_abnormal_cardiovascular_syste0.84869521
60MP0001879_abnormal_lymphatic_vessel0.84767465
61MP0003941_abnormal_skin_development0.84153870
62MP0002009_preneoplasia0.83823433
63MP0009250_abnormal_appendicular_skeleto0.82841617
64MP0003115_abnormal_respiratory_system0.82587829
65MP0003191_abnormal_cellular_cholesterol0.80231791
66MP0004130_abnormal_muscle_cell0.78235469
67MP0002896_abnormal_bone_mineralization0.77495835
68MP0000762_abnormal_tongue_morphology0.76874636
69MP0005334_abnormal_fat_pad0.76219820
70MP0001243_abnormal_dermal_layer0.74474808
71MP0002796_impaired_skin_barrier0.73551709
72* MP0003953_abnormal_hormone_level0.71727402
73MP0002078_abnormal_glucose_homeostasis0.69915861
74MP0009703_decreased_birth_body0.69811139
75MP0000490_abnormal_crypts_of0.69628948
76MP0003279_aneurysm0.69061693
77MP0003937_abnormal_limbs/digits/tail_de0.68970880
78MP0005257_abnormal_intraocular_pressure0.68630746
79MP0003137_abnormal_impulse_conducting0.67643048
80MP0004215_abnormal_myocardial_fiber0.64446972
81MP0010030_abnormal_orbit_morphology0.64147844
82MP0005360_urolithiasis0.63650908
83MP0005409_darkened_coat_color0.63221803
84MP0003935_abnormal_craniofacial_develop0.62639781
85MP0003566_abnormal_cell_adhesion0.62569935
86MP0000733_abnormal_muscle_development0.61640881
87MP0000751_myopathy0.59582365
88MP0004858_abnormal_nervous_system0.59451191
89MP0010155_abnormal_intestine_physiology0.59066990
90MP0005166_decreased_susceptibility_to0.58891853
91MP0003329_amyloid_beta_deposits0.58854976
92MP0002932_abnormal_joint_morphology0.58060797
93MP0000432_abnormal_head_morphology0.58019700
94MP0003385_abnormal_body_wall0.56236988
95MP0005319_abnormal_enzyme/_coenzyme0.54679084
96MP0005376_homeostasis/metabolism_phenot0.54473145
97MP0004859_abnormal_synaptic_plasticity0.53186910
98MP0004197_abnormal_fetal_growth/weight/0.52723668
99MP0002925_abnormal_cardiovascular_devel0.52380016
100MP0008770_decreased_survivor_rate0.51831846
101MP0002697_abnormal_eye_size0.51061956
102MP0001756_abnormal_urination0.50297533
103MP0002876_abnormal_thyroid_physiology0.49895168
104MP0009672_abnormal_birth_weight0.49866974
105* MP0009642_abnormal_blood_homeostasis0.49674377
106MP0000428_abnormal_craniofacial_morphol0.49147234
107MP0004947_skin_inflammation0.48568433
108MP0000266_abnormal_heart_morphology0.48082205
109MP0002116_abnormal_craniofacial_bone0.48081382
110MP0001270_distended_abdomen0.47935810
111MP0005595_abnormal_vascular_smooth0.47871452
112MP0005332_abnormal_amino_acid0.47835935
113MP0000598_abnormal_liver_morphology0.47454683
114MP0003656_abnormal_erythrocyte_physiolo0.47388731
115MP0002751_abnormal_autonomic_nervous0.46693612
116MP0005584_abnormal_enzyme/coenzyme_acti0.46297882
117MP0005076_abnormal_cell_differentiation0.45674297
118MP0000163_abnormal_cartilage_morphology0.44785809
119MP0000013_abnormal_adipose_tissue0.43952417
120MP0000230_abnormal_systemic_arterial0.43773132
121MP0003690_abnormal_glial_cell0.43455532
122MP0008438_abnormal_cutaneous_collagen0.43108857
123MP0009840_abnormal_foam_cell0.42662855
124MP0003122_maternal_imprinting0.42658954
125MP0000367_abnormal_coat/_hair0.42502226
126MP0001299_abnormal_eye_distance/0.42010178
127MP0002938_white_spotting0.41960882
128MP0002115_abnormal_skeleton_extremities0.41941744
129MP0010630_abnormal_cardiac_muscle0.41739026
130MP0002069_abnormal_eating/drinking_beha0.41284281
131MP0003866_abnormal_defecation0.41152199
132MP0004043_abnormal_pH_regulation0.41031953
133MP0003252_abnormal_bile_duct0.40356659
134MP0002111_abnormal_tail_morphology0.40211935
135MP0010352_gastrointestinal_tract_polyps0.40108865
136MP0002084_abnormal_developmental_patter0.40108045
137MP0009643_abnormal_urine_homeostasis0.40054507
138MP0004019_abnormal_vitamin_homeostasis0.39888075
139MP0003221_abnormal_cardiomyocyte_apopto0.39820693
140MP0001440_abnormal_grooming_behavior0.39740958
141MP0001614_abnormal_blood_vessel0.38961322
142MP0000465_gastrointestinal_hemorrhage0.38174069
143MP0005310_abnormal_salivary_gland0.38088208
144MP0005408_hypopigmentation0.38044557
145MP0002109_abnormal_limb_morphology0.37063832
146MP0000609_abnormal_liver_physiology0.36835213
147MP0001216_abnormal_epidermal_layer0.35149076
148MP0002128_abnormal_blood_circulation0.34197283
149MP0000604_amyloidosis0.34047064
150MP0002060_abnormal_skin_morphology0.32773513
151MP0009780_abnormal_chondrocyte_physiolo0.32526262
152MP0006138_congestive_heart_failure0.31333519
153MP0001485_abnormal_pinna_reflex0.30365924
154MP0002972_abnormal_cardiac_muscle0.29446610
155MP0001849_ear_inflammation0.27545188
156MP0005220_abnormal_exocrine_pancreas0.27426448
157MP0010678_abnormal_skin_adnexa0.27011585
158MP0000343_altered_response_to0.26990326
159MP0002693_abnormal_pancreas_physiology0.25324264
160MP0001845_abnormal_inflammatory_respons0.24633951
161MP0002877_abnormal_melanocyte_morpholog0.24046848
162MP0004270_analgesia0.24046797
163MP0009931_abnormal_skin_appearance0.23423956
164MP0005620_abnormal_muscle_contractility0.23119141
165MP0003638_abnormal_response/metabolism_0.22633004
166MP0000003_abnormal_adipose_tissue0.22479394
167MP0005666_abnormal_adipose_tissue0.22025630

Predicted human phenotypes

RankGene SetZ-score
1Megaloblastic anemia (HP:0001889)9.82863462
2Abnormality of the vitamin B12 metabolism (HP:0004341)9.23818011
3Abnormality of vitamin B metabolism (HP:0004340)8.70813430
4Abnormality of vitamin metabolism (HP:0100508)7.10620494
5Right ventricular cardiomyopathy (HP:0011663)5.18701702
6Gout (HP:0001997)4.92520753
7Ventricular fibrillation (HP:0001663)4.02547801
8Abnormal pancreas size (HP:0012094)4.02251747
9Macrocytic anemia (HP:0001972)3.88797533
10Goiter (HP:0000853)3.57510278
11Abnormality of the aortic arch (HP:0012303)3.57182354
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.34635110
13Short 4th metacarpal (HP:0010044)3.34635110
14Syncope (HP:0001279)3.16554941
15Paresthesia (HP:0003401)2.97860971
16Patent foramen ovale (HP:0001655)2.91541308
17Increased purine levels (HP:0004368)2.72149996
18Hyperuricemia (HP:0002149)2.72149996
19Abnormal umbilical cord blood vessels (HP:0011403)2.69356101
20Single umbilical artery (HP:0001195)2.69356101
21Abnormality of the fetal cardiovascular system (HP:0010948)2.69356101
22Cerebral aneurysm (HP:0004944)2.62555853
23Aortic dissection (HP:0002647)2.56658531
24Congenital malformation of the right heart (HP:0011723)2.51288749
25Double outlet right ventricle (HP:0001719)2.51288749
26Malnutrition (HP:0004395)2.49428238
27Tubulointerstitial nephritis (HP:0001970)2.48781902
28Abnormality of the 4th metacarpal (HP:0010012)2.39689713
29Ketoacidosis (HP:0001993)2.37271336
30Ketosis (HP:0001946)2.33016309
31Palpitations (HP:0001962)2.27800197
32Aortic aneurysm (HP:0004942)2.22465079
33Intrahepatic cholestasis (HP:0001406)2.20697925
34Abnormality of purine metabolism (HP:0004352)2.19962301
35Ventricular arrhythmia (HP:0004308)2.19327454
36Neoplasm of the heart (HP:0100544)2.14780862
37Glomerulosclerosis (HP:0000096)2.12304775
38Renal salt wasting (HP:0000127)2.11553536
39Tubulointerstitial fibrosis (HP:0005576)2.08893972
40Bladder diverticulum (HP:0000015)2.06266713
41Woolly hair (HP:0002224)2.05178070
42Abnormality of the middle phalanges of the toes (HP:0010183)2.05125665
43Lymphangioma (HP:0100764)2.03608673
44Abnormality of the distal phalanx of the thumb (HP:0009617)2.03232940
45Abnormal number of erythroid precursors (HP:0012131)18.6074112
46Abnormality of cells of the erythroid lineage (HP:0012130)16.6191043
47Neonatal short-limb short stature (HP:0008921)1.97028390
48Prolonged QT interval (HP:0001657)1.95880616
49Arterial tortuosity (HP:0005116)1.95379872
50Cupped ribs (HP:0000887)1.94681322
51Short tibia (HP:0005736)1.92718276
52Premature rupture of membranes (HP:0001788)1.91395086
53Hyperglycinuria (HP:0003108)1.90732295
54Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.84640189
55Juvenile onset (HP:0003621)1.83425744
56Pulmonary artery stenosis (HP:0004415)1.81551010
57Hyperglycinemia (HP:0002154)1.81429116
58Annular pancreas (HP:0001734)1.80672106
59Deep venous thrombosis (HP:0002625)1.79890190
60Sensorimotor neuropathy (HP:0007141)1.79809435
61Hyperammonemia (HP:0001987)1.78593473
62Aplasia/Hypoplasia of the tibia (HP:0005772)1.75699618
63Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.75570465
64Abnormality of fatty-acid metabolism (HP:0004359)1.74767053
65Abnormality of the phalanges of the hallux (HP:0010057)1.74589755
66Vascular tortuosity (HP:0004948)1.74414885
67Cutaneous finger syndactyly (HP:0010554)1.73493860
68Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.73209361
69Abnormality of glycine metabolism (HP:0010895)1.69521537
70Abnormality of serine family amino acid metabolism (HP:0010894)1.69521537
71Broad palm (HP:0001169)1.68550896
72Abnormality of the proximal phalanges of the hand (HP:0009834)1.67995881
73Abnormality of monocarboxylic acid metabolism (HP:0010996)1.66117263
74Abnormal cartilage morphology (HP:0002763)1.63865982
75Lethargy (HP:0001254)1.63825107
76Abnormality of the 2nd finger (HP:0004100)1.63495902
77Back pain (HP:0003418)1.62415538
78Frequent falls (HP:0002359)1.59044559
79Abnormality of the ischium (HP:0003174)1.57304099
80Gastrointestinal dysmotility (HP:0002579)1.56727886
81Hypoglycemic coma (HP:0001325)1.56416660
82Flared iliac wings (HP:0002869)1.52525081
83Aplasia involving bones of the extremities (HP:0009825)1.52433247
84Aplasia involving bones of the upper limbs (HP:0009823)1.52433247
85Aplasia of the phalanges of the hand (HP:0009802)1.52433247
86Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.52403589
87Abnormality of the umbilical cord (HP:0010881)1.52149992
88Infantile muscular hypotonia (HP:0008947)1.51158666
89Ventricular tachycardia (HP:0004756)1.51000791
90Tubular atrophy (HP:0000092)1.48981369
91Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.47577531
92Short phalanx of the thumb (HP:0009660)1.47424527
93Hypoalphalipoproteinemia (HP:0003233)1.45923777
94Bronchomalacia (HP:0002780)1.45604700
95Cutaneous syndactyly (HP:0012725)1.45579752
96Cervical subluxation (HP:0003308)1.45379206
97Facial diplegia (HP:0001349)1.44853409
98Sudden cardiac death (HP:0001645)1.43885439
99Broad face (HP:0000283)1.43049563
100Dilatation of the ascending aorta (HP:0005111)1.42405480
101Abnormality of permanent molar morphology (HP:0011071)1.42250703
102Abnormality of the dental root (HP:0006486)1.42250703
103Taurodontia (HP:0000679)1.42250703
104Pancreatitis (HP:0001733)1.42230957
105Conjunctival hamartoma (HP:0100780)1.40604917
106Abnormality of the gastric mucosa (HP:0004295)1.39694936
107Atrophic scars (HP:0001075)1.39328959
108Turricephaly (HP:0000262)1.38773182
109Relative macrocephaly (HP:0004482)1.38394931
110Visceral angiomatosis (HP:0100761)1.38379485
111Mitral valve prolapse (HP:0001634)1.38316769
112Aneurysm (HP:0002617)1.37604010
113Wide anterior fontanel (HP:0000260)1.37548298
114Spastic diplegia (HP:0001264)1.36918321
115Abnormal ossification of hand bones (HP:0005921)1.36712147
116Abnormality of molar morphology (HP:0011070)1.36636091
117Abnormality of molar (HP:0011077)1.36636091
118Soft skin (HP:0000977)1.36358503
119Hemorrhage of the eye (HP:0011885)1.35441925
120Transposition of the great arteries (HP:0001669)1.33368191
121Abnormal connection of the cardiac segments (HP:0011545)1.33368191
122Abnormal ventriculo-arterial connection (HP:0011563)1.33368191
123Xanthomatosis (HP:0000991)1.33278544
124Short humerus (HP:0005792)1.32884973
125Cerebral hemorrhage (HP:0001342)1.32534225
126Renal hypoplasia (HP:0000089)1.32049196
127Germ cell neoplasia (HP:0100728)1.31482561
128Protrusio acetabuli (HP:0003179)1.31014237
129Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.30946238
130Abnormal hand bone ossification (HP:0010660)1.29603890
131Abnormal biliary tract morphology (HP:0012440)1.29563240
132Hyperglycemia (HP:0003074)1.27952810
133Truncus arteriosus (HP:0001660)1.27936212
134Ankyloglossia (HP:0010296)1.27781517
135Limited hip movement (HP:0008800)1.27684924
136Aortic regurgitation (HP:0001659)1.27215713
137Seborrheic dermatitis (HP:0001051)1.26720858
138Abnormality of nucleobase metabolism (HP:0010932)1.26670388
139Abdominal situs inversus (HP:0003363)1.26350078
140Abnormality of abdominal situs (HP:0011620)1.26350078
141Broad forehead (HP:0000337)1.26132518
142Short middle phalanx of finger (HP:0005819)1.25293873
143Hemangiomatosis (HP:0007461)1.24580336
144Abnormality of the renal cortex (HP:0011035)1.24398859
145Abnormality of the epiphyses of the hand (HP:0005924)1.23989704
146Ankle contracture (HP:0006466)1.23918053
147Stroke (HP:0001297)1.22500455
148Abnormal EKG (HP:0003115)1.22371772
149Fragile skin (HP:0001030)1.22150504
150Aplasia/hypoplasia of the humerus (HP:0006507)1.22018025
151Abnormality of the dental pulp (HP:0006479)1.21915050
152Growth hormone excess (HP:0000845)1.21072457
153Abnormality of dicarboxylic acid metabolism (HP:0010995)1.19648643
154Dicarboxylic aciduria (HP:0003215)1.19648643
155Vascular calcification (HP:0004934)1.18038497
156Testicular neoplasm (HP:0010788)1.17571797
157Hyperparathyroidism (HP:0000843)1.16041683
158Abnormality of oral frenula (HP:0000190)1.15251249
159Hypotension (HP:0002615)1.14239670
160Macroglossia (HP:0000158)1.13579709
161Curly hair (HP:0002212)1.13325811
162Increased variability in muscle fiber diameter (HP:0003557)1.13099024
163Scapular winging (HP:0003691)1.12897449
164Pustule (HP:0200039)1.12645203
165Rectal prolapse (HP:0002035)1.12450234
166Osteolytic defects of the phalanges of the hand (HP:0009771)1.12301893
167Osteolytic defects of the hand bones (HP:0009699)1.12301893
168Pheochromocytoma (HP:0002666)1.11287889
169Cardiovascular calcification (HP:0011915)1.11257470
170Type 1 muscle fiber predominance (HP:0003803)1.10509569
171Vomiting (HP:0002013)1.08827683
172Broad metatarsal (HP:0001783)1.08721469
173Amyloidosis (HP:0011034)1.08592216
174Hypoplastic left heart (HP:0004383)1.07986303
175Metabolic acidosis (HP:0001942)1.06798006
176Esophageal varix (HP:0002040)1.06586310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST46.16854990
2MST1R5.53361827
3BCKDK4.12424315
4MYLK3.92211782
5TRIB33.72355967
6MAPK153.11182845
7LRRK22.75516939
8KSR22.67878719
9PIK3CG2.62122103
10ERBB42.57038103
11PKN22.48604359
12MET2.39629237
13RIPK42.39069463
14ZAP701.96163671
15LATS11.83286714
16STK101.73486787
17ERN11.63128068
18LMTK21.58833915
19PAK31.57179440
20PDGFRB1.55278127
21WNK41.53196917
22MAP3K21.52425747
23MAP3K91.48277553
24PDK21.46841903
25PTK61.45991329
26STK391.45869689
27ROCK21.41456939
28GRK71.41438080
29NUAK11.40720724
30MAP3K101.35871731
31TTN1.32667012
32PRKCI1.24462266
33FER1.10674087
34MAP2K11.10170905
35STK38L1.09286573
36TESK11.08343034
37PDK31.07838311
38PDK41.07838311
39DDR21.06030358
40ROCK10.96592291
41RPS6KA20.95885185
42BRD40.95874456
43PAK20.91447047
44EPHB10.89803490
45FGFR30.88653612
46PAK60.86667383
47MAP2K20.82820995
48TIE10.81479652
49PDPK10.80962729
50INSRR0.79326689
51PRKG20.79297689
52NEK10.76601772
53FGFR40.75322824
54NME10.72828135
55NTRK10.72530566
56AKT30.72087865
57CDK30.71528859
58LIMK10.69431940
59NEK20.66577600
60SMG10.65198975
61RIPK10.64844845
62MAP3K80.63338267
63KSR10.62681851
64EEF2K0.61799100
65PDK10.58768253
66FRK0.57142187
67DMPK0.56960645
68CASK0.56948887
69PTK20.56393770
70CDC42BPA0.56383598
71NTRK30.56331002
72FYN0.56068699
73PAK10.54100543
74CAMK1G0.54026264
75PAK40.53846394
76RET0.53798906
77NLK0.53416911
78STK110.53118650
79CDK120.53051394
80RAF10.52343192
81DAPK30.52334574
82CAMK1D0.52218373
83VRK10.51084620
84LATS20.50611908
85MAP2K60.49857851
86ICK0.49382121
87RPS6KL10.48243297
88RPS6KC10.48243297
89EGFR0.48164699
90MTOR0.47772900
91PIK3CA0.46869873
92SGK2230.46327546
93SGK4940.46327546
94JAK20.45458582
95NME20.44966630
96PHKG20.44605533
97PHKG10.44605533
98CAMK40.42055954
99WNK10.40945851
100SGK20.40185312
101MINK10.39970295
102PDGFRA0.39922462
103WEE10.39385718
104OXSR10.39255364
105EPHB20.39072962
106MELK0.38085343
107TYRO30.37058805
108MATK0.36955533
109MARK20.36459892
110GRK60.36213285
111PRKAA20.35177974
112FGFR10.34885076
113BMX0.33408728
114FGFR20.33281889
115SRC0.33215877
116CDK90.33202391
117RPS6KB20.33192556
118RPS6KA60.33170127
119ILK0.31808302
120TGFBR20.31150629
121MAP3K120.31108920
122STK30.30942761
123ALK0.30934215
124CAMK10.30070585
125CAMKK10.29023629
126KDR0.28502369
127PRKD30.28476094
128MAPK10.28312295
129BRSK20.27080238
130MAPK30.26986690
131CDK190.26546796
132MAP2K40.26515519
133CSK0.26166320
134ERBB20.25815280
135NEK90.25672418
136AKT20.24150383
137GSK3A0.23341827
138PTK2B0.22560382
139SGK30.22110833
140CDK50.21757022
141MAP3K10.21697543
142RPS6KA10.21602792
143PRKACB0.21522229
144MAP3K40.21391314
145MAPK70.21251294
146PRKD10.21087424
147MAP3K130.20276748
148IGF1R0.19635059
149GSK3B0.17831920
150MKNK20.16897897
151INSR0.16811431
152AKT10.16457180
153PRKDC0.16181635
154ADRBK10.15872539
155FGR0.14453525
156BMPR1B0.14262210
157PNCK0.13198155

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.05430538
2* Collecting duct acid secretion_Homo sapiens_hsa049664.77535231
3Vitamin digestion and absorption_Homo sapiens_hsa049774.56564655
4* Gastric acid secretion_Homo sapiens_hsa049714.39682578
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.23480157
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.87019145
7Linoleic acid metabolism_Homo sapiens_hsa005913.67264256
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.21014959
9Chemical carcinogenesis_Homo sapiens_hsa052042.86147529
10Sulfur metabolism_Homo sapiens_hsa009202.49653124
11Protein digestion and absorption_Homo sapiens_hsa049742.49426740
12Ether lipid metabolism_Homo sapiens_hsa005652.30691527
13Glutathione metabolism_Homo sapiens_hsa004802.25347744
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.04247277
15Pancreatic secretion_Homo sapiens_hsa049721.96761465
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.84701119
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84537923
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.79666610
19Fatty acid degradation_Homo sapiens_hsa000711.49552476
20Propanoate metabolism_Homo sapiens_hsa006401.45086896
21Arachidonic acid metabolism_Homo sapiens_hsa005901.41541382
22Nitrogen metabolism_Homo sapiens_hsa009101.31776439
23Hedgehog signaling pathway_Homo sapiens_hsa043401.24374999
24Glycerolipid metabolism_Homo sapiens_hsa005611.23291677
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22124437
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.17772910
27Retinol metabolism_Homo sapiens_hsa008301.15035571
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10523948
29ECM-receptor interaction_Homo sapiens_hsa045121.09289020
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06302625
31Bile secretion_Homo sapiens_hsa049761.01725087
32Thyroid hormone synthesis_Homo sapiens_hsa049181.01214539
33Glycerophospholipid metabolism_Homo sapiens_hsa005640.98104198
34Focal adhesion_Homo sapiens_hsa045100.97170819
35Basal cell carcinoma_Homo sapiens_hsa052170.97136440
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97095840
37Inositol phosphate metabolism_Homo sapiens_hsa005620.95325977
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92920860
39* Oxidative phosphorylation_Homo sapiens_hsa001900.92298084
40Notch signaling pathway_Homo sapiens_hsa043300.90605272
41Butanoate metabolism_Homo sapiens_hsa006500.87670864
42Adherens junction_Homo sapiens_hsa045200.86813769
43Phenylalanine metabolism_Homo sapiens_hsa003600.82951886
44beta-Alanine metabolism_Homo sapiens_hsa004100.81097231
45Histidine metabolism_Homo sapiens_hsa003400.80104589
46Arginine biosynthesis_Homo sapiens_hsa002200.79032005
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77805012
48Carbon metabolism_Homo sapiens_hsa012000.77046527
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76075696
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73450596
51Pyruvate metabolism_Homo sapiens_hsa006200.68514354
52TGF-beta signaling pathway_Homo sapiens_hsa043500.67654517
53Fatty acid metabolism_Homo sapiens_hsa012120.66336169
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66136078
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65528834
56Chronic myeloid leukemia_Homo sapiens_hsa052200.65374143
57Lysine degradation_Homo sapiens_hsa003100.63057252
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61397347
59Tyrosine metabolism_Homo sapiens_hsa003500.61355445
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59471718
61Hepatitis C_Homo sapiens_hsa051600.58971633
62Choline metabolism in cancer_Homo sapiens_hsa052310.57409478
63Amoebiasis_Homo sapiens_hsa051460.53893487
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52347828
65Hippo signaling pathway_Homo sapiens_hsa043900.51700180
66Small cell lung cancer_Homo sapiens_hsa052220.50973231
67Salivary secretion_Homo sapiens_hsa049700.49039859
68Biosynthesis of amino acids_Homo sapiens_hsa012300.48168707
69Renal cell carcinoma_Homo sapiens_hsa052110.46169551
70Pathways in cancer_Homo sapiens_hsa052000.45127008
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45122921
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44229365
73Mineral absorption_Homo sapiens_hsa049780.43464054
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43440929
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42206449
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.41856374
77ErbB signaling pathway_Homo sapiens_hsa040120.41734782
78Taste transduction_Homo sapiens_hsa047420.40987299
79PPAR signaling pathway_Homo sapiens_hsa033200.40641744
80Circadian rhythm_Homo sapiens_hsa047100.39294444
81Tryptophan metabolism_Homo sapiens_hsa003800.38488418
82Prostate cancer_Homo sapiens_hsa052150.38445289
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37837994
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37025726
85Axon guidance_Homo sapiens_hsa043600.35667694
86Melanogenesis_Homo sapiens_hsa049160.35551562
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.35370626
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35201481
89Tight junction_Homo sapiens_hsa045300.34847341
90Colorectal cancer_Homo sapiens_hsa052100.34773982
91Rap1 signaling pathway_Homo sapiens_hsa040150.34693852
92Cocaine addiction_Homo sapiens_hsa050300.34680995
93Endometrial cancer_Homo sapiens_hsa052130.34645057
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.32686058
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.31585147
96Wnt signaling pathway_Homo sapiens_hsa043100.30008578
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.28993106
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28874734
99Bladder cancer_Homo sapiens_hsa052190.28414535
100Cardiac muscle contraction_Homo sapiens_hsa042600.28107782
101MicroRNAs in cancer_Homo sapiens_hsa052060.28107271
102Lysosome_Homo sapiens_hsa041420.27689354
103Platelet activation_Homo sapiens_hsa046110.27462540
104Fatty acid biosynthesis_Homo sapiens_hsa000610.27134813
105Pentose phosphate pathway_Homo sapiens_hsa000300.26745943
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25670608
107Calcium signaling pathway_Homo sapiens_hsa040200.25323503
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23597295
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.23344671
110Peroxisome_Homo sapiens_hsa041460.22666428
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21587262
112AMPK signaling pathway_Homo sapiens_hsa041520.21111937
113Estrogen signaling pathway_Homo sapiens_hsa049150.20455895
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.19778255
115Insulin signaling pathway_Homo sapiens_hsa049100.19430436
116Fatty acid elongation_Homo sapiens_hsa000620.18593642
117Melanoma_Homo sapiens_hsa052180.18331066
118mTOR signaling pathway_Homo sapiens_hsa041500.17916637
119Insulin secretion_Homo sapiens_hsa049110.17544908
120Thyroid cancer_Homo sapiens_hsa052160.17252222
121Circadian entrainment_Homo sapiens_hsa047130.16776682
122Prolactin signaling pathway_Homo sapiens_hsa049170.15939910
123Renin secretion_Homo sapiens_hsa049240.15536362
124Glioma_Homo sapiens_hsa052140.13451305
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.12798325
126Cholinergic synapse_Homo sapiens_hsa047250.12775987
127Endocytosis_Homo sapiens_hsa041440.12665568
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12461947
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11866400
130Fructose and mannose metabolism_Homo sapiens_hsa000510.11829422
131Amphetamine addiction_Homo sapiens_hsa050310.11403971
132Non-small cell lung cancer_Homo sapiens_hsa052230.10793272
133cAMP signaling pathway_Homo sapiens_hsa040240.10419785
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.10214253
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.09290830
136Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.08974966
137VEGF signaling pathway_Homo sapiens_hsa043700.08635261
138Vibrio cholerae infection_Homo sapiens_hsa051100.07884692
139ABC transporters_Homo sapiens_hsa020100.07542260
140GnRH signaling pathway_Homo sapiens_hsa049120.07496253
141Proteoglycans in cancer_Homo sapiens_hsa052050.06418584
142Insulin resistance_Homo sapiens_hsa049310.06342157
143Long-term potentiation_Homo sapiens_hsa047200.06290573
144Metabolic pathways_Homo sapiens_hsa011000.06253278
145Ras signaling pathway_Homo sapiens_hsa040140.06023126
146Dorso-ventral axis formation_Homo sapiens_hsa043200.05476013
147Glucagon signaling pathway_Homo sapiens_hsa049220.04814863
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.03848914
149Dilated cardiomyopathy_Homo sapiens_hsa054140.03796405
150Alzheimers disease_Homo sapiens_hsa050100.01768396
151Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.01541160
152African trypanosomiasis_Homo sapiens_hsa051430.00960951
153Gap junction_Homo sapiens_hsa04540-0.0095533
154Regulation of actin cytoskeleton_Homo sapiens_hsa04810-0.0092215
155Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0090262
156Starch and sucrose metabolism_Homo sapiens_hsa00500-0.0070479
157Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0056753
158Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0048696

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