ATP5A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)7.91720357
2NADH metabolic process (GO:0006734)6.11791545
3regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.51671672
4lysine metabolic process (GO:0006553)5.49044372
5lysine catabolic process (GO:0006554)5.49044372
6sarcomere organization (GO:0045214)5.32026095
7cardiac myofibril assembly (GO:0055003)5.15312103
8regulation of acyl-CoA biosynthetic process (GO:0050812)5.06672596
9regulation of coenzyme metabolic process (GO:0051196)5.01558041
10regulation of cofactor metabolic process (GO:0051193)5.01558041
11oxaloacetate metabolic process (GO:0006107)5.01034813
122-oxoglutarate metabolic process (GO:0006103)5.00223936
13negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.98214848
14succinate metabolic process (GO:0006105)4.96041056
15tricarboxylic acid metabolic process (GO:0072350)4.93448087
16oxidative phosphorylation (GO:0006119)4.89796475
17carnitine shuttle (GO:0006853)4.74583704
18negative regulation of potassium ion transmembrane transport (GO:1901380)4.73419285
19aspartate family amino acid catabolic process (GO:0009068)4.61620753
20cardiac muscle contraction (GO:0060048)4.58294363
21cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.50833198
22fatty acid transmembrane transport (GO:1902001)4.17674066
23myofibril assembly (GO:0030239)4.08277046
24positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.06982938
25muscle filament sliding (GO:0030049)4.06094113
26actin-myosin filament sliding (GO:0033275)4.06094113
27cell communication by electrical coupling (GO:0010644)4.02774791
28regulation of sulfur metabolic process (GO:0042762)3.98863030
29plasma membrane repair (GO:0001778)3.91532684
30* mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.91076148
31cardiac muscle cell development (GO:0055013)3.88798159
32regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.87437564
33ventricular cardiac muscle cell action potential (GO:0086005)3.87204810
34regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.86533902
35cell communication involved in cardiac conduction (GO:0086065)3.81262287
36regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.70679322
37regulation of fatty acid oxidation (GO:0046320)3.69702133
38fatty acid beta-oxidation (GO:0006635)3.68498342
39establishment of integrated proviral latency (GO:0075713)3.68229380
40gluconeogenesis (GO:0006094)3.65299681
41amino-acid betaine transport (GO:0015838)3.65206260
42carnitine transport (GO:0015879)3.65206260
43establishment of protein localization to mitochondrial membrane (GO:0090151)3.63724718
44cardiac cell development (GO:0055006)3.59068664
45carnitine transmembrane transport (GO:1902603)3.58207234
46regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.54403796
47cullin deneddylation (GO:0010388)3.51316606
48actomyosin structure organization (GO:0031032)3.51253327
49* ATP synthesis coupled proton transport (GO:0015986)3.42263613
50* energy coupled proton transport, down electrochemical gradient (GO:0015985)3.42263613
51bundle of His cell to Purkinje myocyte communication (GO:0086069)3.36737437
52acetyl-CoA metabolic process (GO:0006084)3.36427459
53membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.36232188
54striated muscle contraction (GO:0006941)3.35925064
55hexose biosynthetic process (GO:0019319)3.35800719
56cardiac muscle hypertrophy (GO:0003300)3.28812130
57* respiratory electron transport chain (GO:0022904)3.26568288
58branched-chain amino acid catabolic process (GO:0009083)3.23243952
59cellular ketone body metabolic process (GO:0046950)3.22978597
60protein deneddylation (GO:0000338)3.19388020
61actin-mediated cell contraction (GO:0070252)3.18748150
62* electron transport chain (GO:0022900)3.16596499
63fatty acid homeostasis (GO:0055089)3.16095045
64regulation of actin filament-based movement (GO:1903115)3.15845104
65regulation of membrane repolarization (GO:0060306)3.15430222
66chromatin remodeling at centromere (GO:0031055)3.15225762
67negative regulation of cell size (GO:0045792)3.12179798
68regulation of the force of heart contraction (GO:0002026)3.10548309
69striated muscle hypertrophy (GO:0014897)3.10491377
70branched-chain amino acid metabolic process (GO:0009081)3.10134899
71monosaccharide biosynthetic process (GO:0046364)3.09132783
72glycolytic process (GO:0006096)3.09083235
73water-soluble vitamin biosynthetic process (GO:0042364)3.07252226
74DNA strand elongation involved in DNA replication (GO:0006271)3.07189375
75regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.06777187
76regulation of mitochondrial translation (GO:0070129)3.06636298
77fatty acid oxidation (GO:0019395)3.05779642
78proteasome assembly (GO:0043248)3.05641690
79CENP-A containing nucleosome assembly (GO:0034080)3.05496372
80valine metabolic process (GO:0006573)3.05074351
81heart trabecula formation (GO:0060347)3.04607542
82short-chain fatty acid metabolic process (GO:0046459)3.04503554
83pyruvate metabolic process (GO:0006090)3.03798441
84L-serine metabolic process (GO:0006563)3.03553592
85somatic hypermutation of immunoglobulin genes (GO:0016446)3.01292189
86somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01292189
87sodium ion export (GO:0071436)3.01238945
88quaternary ammonium group transport (GO:0015697)3.00914354
89regulation of translational termination (GO:0006449)2.99066018
90fatty acid catabolic process (GO:0009062)2.98436220
91lipid oxidation (GO:0034440)2.97757908
92DNA ligation (GO:0006266)2.96616899
93cardiac muscle tissue morphogenesis (GO:0055008)2.96502679
94cardiac muscle cell action potential involved in contraction (GO:0086002)2.95592871
95dicarboxylic acid biosynthetic process (GO:0043650)2.94266120
96membrane repolarization during action potential (GO:0086011)2.93860562
97glyoxylate metabolic process (GO:0046487)2.93689256
98regulation of fatty acid beta-oxidation (GO:0031998)2.93543606
99IMP biosynthetic process (GO:0006188)2.92883323
100negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.92190223
101mitochondrial respiratory chain complex I assembly (GO:0032981)2.92121441
102NADH dehydrogenase complex assembly (GO:0010257)2.92121441
103mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92121441
104chaperone-mediated protein transport (GO:0072321)2.91670821
105DNA strand elongation (GO:0022616)2.89746738
106adult heart development (GO:0007512)2.88957852
107carnitine metabolic process (GO:0009437)2.88544416
108cardiac muscle cell action potential (GO:0086001)2.86059422
109galactose catabolic process (GO:0019388)2.83549169
110ketone body metabolic process (GO:1902224)2.82818284
111regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82210864
112regulation of sequestering of triglyceride (GO:0010889)2.81773126
113DNA double-strand break processing (GO:0000729)2.81540269
114aerobic respiration (GO:0009060)2.81463231
115L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.80791345
116ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.80496977
117mitochondrial respiratory chain complex assembly (GO:0033108)2.80479208
118regulation of sarcomere organization (GO:0060297)2.80329842
119heart process (GO:0003015)2.79046077
120heart contraction (GO:0060047)2.79046077
121protein complex biogenesis (GO:0070271)2.77160357
122mitochondrial fusion (GO:0008053)2.77094208
123positive regulation of fatty acid oxidation (GO:0046321)2.77059190
124formation of translation preinitiation complex (GO:0001731)2.76795990
125tRNA aminoacylation for protein translation (GO:0006418)2.76674339
126IMP metabolic process (GO:0046040)2.74956048
127ubiquinone metabolic process (GO:0006743)2.74140323
128regulation of skeletal muscle contraction (GO:0014819)2.73918271
129amino acid activation (GO:0043038)2.73055364
130tRNA aminoacylation (GO:0043039)2.73055364
131establishment of viral latency (GO:0019043)2.72856462
132DNA damage response, detection of DNA damage (GO:0042769)2.71391342
133telomere maintenance via semi-conservative replication (GO:0032201)2.71123778
134anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70920689
135ubiquinone biosynthetic process (GO:0006744)2.70748038
136mitochondrial RNA metabolic process (GO:0000959)2.70580909
137regulation of translational fidelity (GO:0006450)2.70064215
138* ATP biosynthetic process (GO:0006754)2.69878154
139positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.67818066
140mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.66282516
141DNA replication checkpoint (GO:0000076)2.65740665
142purine nucleobase biosynthetic process (GO:0009113)2.65348316
143synapsis (GO:0007129)2.64801032
144non-recombinational repair (GO:0000726)2.63352431
145double-strand break repair via nonhomologous end joining (GO:0006303)2.63352431
146aldehyde catabolic process (GO:0046185)2.63091589
147inner mitochondrial membrane organization (GO:0007007)2.63058847
148respiratory chain complex IV assembly (GO:0008535)2.61261052
149negative regulation of ligase activity (GO:0051352)2.60164659
150negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60164659
151protein targeting to mitochondrion (GO:0006626)2.59765145
152cellular respiration (GO:0045333)2.59697564
153histone exchange (GO:0043486)2.58644183
154ribosome assembly (GO:0042255)2.52888755
155nucleobase biosynthetic process (GO:0046112)2.50951805
156establishment of protein localization to mitochondrion (GO:0072655)2.48572343
157DNA replication-dependent nucleosome assembly (GO:0006335)2.47481752
158DNA replication-dependent nucleosome organization (GO:0034723)2.47481752
159protein localization to mitochondrion (GO:0070585)2.46036128
160DNA replication-independent nucleosome assembly (GO:0006336)2.40796360
161DNA replication-independent nucleosome organization (GO:0034724)2.40796360
162exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.40791711
163nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.40772646
164regulation of cellular amino acid metabolic process (GO:0006521)2.39370436
165maturation of 5.8S rRNA (GO:0000460)2.37484507
166DNA catabolic process, exonucleolytic (GO:0000738)2.36089935
167resolution of meiotic recombination intermediates (GO:0000712)2.36069910
168ribosomal small subunit assembly (GO:0000028)2.36015458
169RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.35857739
170tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.35857739
171ribosomal large subunit biogenesis (GO:0042273)2.35278453
172mitotic spindle checkpoint (GO:0071174)2.35185886
173protein neddylation (GO:0045116)2.34773420
174L-methionine salvage (GO:0071267)2.33851677
175L-methionine biosynthetic process (GO:0071265)2.33851677
176amino acid salvage (GO:0043102)2.33851677
177spliceosomal snRNP assembly (GO:0000387)2.33444613
178positive regulation of mitochondrial fission (GO:0090141)2.32003538
179spindle checkpoint (GO:0031577)2.31756397
180nucleotide-excision repair, DNA gap filling (GO:0006297)2.31689632
181positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.30063606
182DNA unwinding involved in DNA replication (GO:0006268)2.29650797
183transcription elongation from RNA polymerase III promoter (GO:0006385)2.29263795

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.49931587
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.42994755
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.08921116
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.97735572
5E2F7_22180533_ChIP-Seq_HELA_Human3.76995827
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.75345572
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.43241304
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.41714418
9ZNF263_19887448_ChIP-Seq_K562_Human3.26251781
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.17127350
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.06605556
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.79630719
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.79048243
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.65428395
15CLOCK_20551151_ChIP-Seq_293T_Human2.57802464
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57486435
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.54926156
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35148945
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.32908367
20* MYC_18555785_ChIP-Seq_MESCs_Mouse2.28954508
21* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.18530665
22ESR1_15608294_ChIP-ChIP_MCF-7_Human2.08154049
23* RXR_22158963_ChIP-Seq_LIVER_Mouse2.02638485
24AR_21909140_ChIP-Seq_LNCAP_Human2.02424909
25IGF1R_20145208_ChIP-Seq_DFB_Human2.02181912
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.97298437
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95537259
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93852251
29ELK1_19687146_ChIP-ChIP_HELA_Human1.93751942
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.92466564
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91378579
32VDR_23849224_ChIP-Seq_CD4+_Human1.88605096
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87473878
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87152757
35FOXP3_21729870_ChIP-Seq_TREG_Human1.85151142
36* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.83613552
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.79458548
38TTF2_22483619_ChIP-Seq_HELA_Human1.77694522
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.72881012
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71129300
41MYC_18940864_ChIP-ChIP_HL60_Human1.70383286
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68751102
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68386999
44* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66145639
45* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66070721
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.66028093
47MYC_22102868_ChIP-Seq_BL_Human1.65775177
48DCP1A_22483619_ChIP-Seq_HELA_Human1.65288873
49* TBX20_22328084_ChIP-Seq_HEART_Mouse1.61726240
50* TBX20_22080862_ChIP-Seq_HEART_Mouse1.61726240
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56710216
52ATF3_27146783_Chip-Seq_COLON_Human1.54514878
53FUS_26573619_Chip-Seq_HEK293_Human1.54094555
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51122639
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49876399
56* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49304866
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48562334
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48050457
59LXR_22158963_ChIP-Seq_LIVER_Mouse1.46922284
60ZNF274_21170338_ChIP-Seq_K562_Hela1.46916534
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.45610367
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44673771
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.44566276
64* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44514648
65EWS_26573619_Chip-Seq_HEK293_Human1.44395238
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.44064055
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43806703
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.43232543
69IRF1_19129219_ChIP-ChIP_H3396_Human1.42633026
70CIITA_25753668_ChIP-Seq_RAJI_Human1.41238298
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.40905882
72GATA4_21415370_ChIP-Seq_HL-1_Mouse1.38582853
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37850322
74EZH2_22144423_ChIP-Seq_EOC_Human1.37591508
75* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36532718
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36214652
77VDR_22108803_ChIP-Seq_LS180_Human1.35333576
78MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.30368009
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30262844
80THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28571382
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28432630
82LXR_22292898_ChIP-Seq_THP-1_Human1.27682148
83XRN2_22483619_ChIP-Seq_HELA_Human1.25376271
84NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24358017
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23969146
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23521552
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23452169
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22646689
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21068023
90* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20599987
91GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.19449897
92E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18949303
93RACK7_27058665_Chip-Seq_MCF-7_Human1.18885476
94NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.18660139
95P68_20966046_ChIP-Seq_HELA_Human1.17604476
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16387383
97NANOG_21062744_ChIP-ChIP_HESCs_Human1.16136712
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15630878
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14775036
100ETS1_20019798_ChIP-Seq_JURKAT_Human1.11791776
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11511283
102OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11355289
103* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10319022
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09440224
105TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08861024
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08681711
107SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08353340
108EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08117703
109ESR1_20079471_ChIP-ChIP_T-47D_Human1.07201179
110* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06462625
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06436844
112POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04792168
113* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04514594
114* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04455785
115TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04210227
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02052175
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01719930
118* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00955375
119CREB1_26743006_Chip-Seq_LNCaP_Human1.00935511
120KDM2B_26808549_Chip-Seq_DND41_Human1.00818539
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00755084
122SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00740965
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00735129
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99364808
125EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99276247
126ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98660717
127* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98613169
128MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98400390
129MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96863438
130RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96811486
131E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96543315
132POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96323660
133TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96081366
134E2F1_21310950_ChIP-Seq_MCF-7_Human0.95907545
135TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95585357
136FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95511966
137TAF15_26573619_Chip-Seq_HEK293_Human0.95394843
138CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93947331
139CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93558268
140RARB_27405468_Chip-Seq_BRAIN_Mouse0.92628509
141SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92527146
142SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91657836
143GATA1_26923725_Chip-Seq_HPCs_Mouse0.91591478
144KDM5A_27292631_Chip-Seq_BREAST_Human0.91514939
145* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.90604027
146P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90480706
147GBX2_23144817_ChIP-Seq_PC3_Human0.90386886
148GABP_19822575_ChIP-Seq_HepG2_Human0.89911564
149CHD1_26751641_Chip-Seq_LNCaP_Human0.89812149
150DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88599376
151ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88563713
152ELK3_25401928_ChIP-Seq_HUVEC_Human0.88562183
153RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87547770
154FLI1_27457419_Chip-Seq_LIVER_Mouse0.87149426
155RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86797267
156SOX17_20123909_ChIP-Seq_XEN_Mouse0.86453370
157* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85746361
158PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85455895
159CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85186898
160SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84944954
161SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84296326
162MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81093826
163KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80687175
164RNF2_27304074_Chip-Seq_NSC_Mouse0.79537817
165HTT_18923047_ChIP-ChIP_STHdh_Human0.76962609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.16090160
2MP0004084_abnormal_cardiac_muscle4.73790093
3MP0003646_muscle_fatigue4.18498447
4MP0000751_myopathy3.98867611
5MP0004215_abnormal_myocardial_fiber3.82382158
6MP0004036_abnormal_muscle_relaxation3.33222632
7MP0005330_cardiomyopathy3.09632401
8MP0008058_abnormal_DNA_repair2.76428448
9MP0003693_abnormal_embryo_hatching2.74930807
10MP0010094_abnormal_chromosome_stability2.61338920
11MP0004130_abnormal_muscle_cell2.61002389
12MP0000749_muscle_degeneration2.54497914
13MP0008877_abnormal_DNA_methylation2.54414958
14MP0004087_abnormal_muscle_fiber2.52468900
15MP0002972_abnormal_cardiac_muscle2.40889644
16MP0008775_abnormal_heart_ventricle2.37853152
17MP0006036_abnormal_mitochondrial_physio2.30808359
18MP0003221_abnormal_cardiomyocyte_apopto2.27358870
19MP0004233_abnormal_muscle_weight2.26695643
20MP0002269_muscular_atrophy2.26074345
21MP0003806_abnormal_nucleotide_metabolis2.22195789
22MP0000372_irregular_coat_pigmentation2.17610766
23MP0005360_urolithiasis2.17541933
24MP0005620_abnormal_muscle_contractility2.13754155
25MP0003111_abnormal_nucleus_morphology2.11109746
26MP0001529_abnormal_vocalization2.08539247
27MP0002102_abnormal_ear_morphology2.06387834
28MP0001544_abnormal_cardiovascular_syste2.06272045
29MP0005385_cardiovascular_system_phenoty2.06272045
30MP0003137_abnormal_impulse_conducting2.04684997
31MP0010630_abnormal_cardiac_muscle2.03580952
32MP0003705_abnormal_hypodermis_morpholog2.03356923
33MP0006138_congestive_heart_failure1.97452715
34MP0000747_muscle_weakness1.92665817
35MP0000750_abnormal_muscle_regeneration1.91188132
36MP0003136_yellow_coat_color1.86740408
37MP0002938_white_spotting1.86057764
38MP0003880_abnormal_central_pattern1.81812810
39MP0002106_abnormal_muscle_physiology1.78108648
40MP0004043_abnormal_pH_regulation1.77692684
41MP0005666_abnormal_adipose_tissue1.77094798
42MP0004484_altered_response_of1.76921736
43MP0008932_abnormal_embryonic_tissue1.76072819
44MP0010234_abnormal_vibrissa_follicle1.73456815
45MP0003718_maternal_effect1.71732160
46MP0003077_abnormal_cell_cycle1.66182897
47MP0006035_abnormal_mitochondrial_morpho1.59473818
48MP0006292_abnormal_olfactory_placode1.56891224
49MP0004085_abnormal_heartbeat1.54917312
50MP0002139_abnormal_hepatobiliary_system1.51011848
51MP0003123_paternal_imprinting1.49305543
52MP0000759_abnormal_skeletal_muscle1.46315468
53MP0005332_abnormal_amino_acid1.45665461
54MP0006072_abnormal_retinal_apoptosis1.44380674
55MP0004145_abnormal_muscle_electrophysio1.42603327
56MP0001293_anophthalmia1.41494021
57MP0003121_genomic_imprinting1.41488068
58MP0003567_abnormal_fetal_cardiomyocyte1.38590803
59MP0005369_muscle_phenotype1.38564068
60MP0002909_abnormal_adrenal_gland1.35793976
61MP0005085_abnormal_gallbladder_physiolo1.33855816
62MP0003787_abnormal_imprinting1.31725094
63MP0001984_abnormal_olfaction1.31567354
64MP0004270_analgesia1.31069072
65MP0008789_abnormal_olfactory_epithelium1.30293175
66MP0003890_abnormal_embryonic-extraembry1.29351580
67MP0005670_abnormal_white_adipose1.28214923
68MP0008961_abnormal_basal_metabolism1.27399252
69MP0003941_abnormal_skin_development1.27124573
70MP0000013_abnormal_adipose_tissue1.26990360
71MP0006276_abnormal_autonomic_nervous1.25826764
72MP0008007_abnormal_cellular_replicative1.23227819
73MP0005375_adipose_tissue_phenotype1.22932892
74MP0002234_abnormal_pharynx_morphology1.22460872
75MP0005266_abnormal_metabolism1.19215929
76MP0009697_abnormal_copulation1.18134666
77MP0005187_abnormal_penis_morphology1.17256687
78MP0002160_abnormal_reproductive_system1.17053401
79MP0003937_abnormal_limbs/digits/tail_de1.16605430
80MP0004185_abnormal_adipocyte_glucose1.16530638
81MP0005394_taste/olfaction_phenotype1.14648530
82MP0005499_abnormal_olfactory_system1.14648530
83MP0002272_abnormal_nervous_system1.11958367
84MP0009046_muscle_twitch1.11289940
85MP0001188_hyperpigmentation1.09539853
86MP0002127_abnormal_cardiovascular_syste1.08480409
87MP0005365_abnormal_bile_salt1.08439741
88MP0003283_abnormal_digestive_organ1.08347806
89MP0001730_embryonic_growth_arrest1.07183428
90MP0003315_abnormal_perineum_morphology1.06482277
91MP0002734_abnormal_mechanical_nocicepti1.06391138
92MP0003186_abnormal_redox_activity1.06372451
93MP0001485_abnormal_pinna_reflex1.06004749
94MP0005253_abnormal_eye_physiology1.04740065
95MP0002638_abnormal_pupillary_reflex1.04313919
96MP0010352_gastrointestinal_tract_polyps1.03724770
97MP0002332_abnormal_exercise_endurance1.02512059
98MP0005171_absent_coat_pigmentation1.02137055
99MP0000537_abnormal_urethra_morphology1.00523678
100MP0005423_abnormal_somatic_nervous1.00303121
101MP0000266_abnormal_heart_morphology1.00111554
102MP0010329_abnormal_lipoprotein_level0.99189224
103MP0010030_abnormal_orbit_morphology0.98878171
104MP0004133_heterotaxia0.98732259
105MP0000003_abnormal_adipose_tissue0.98277256
106MP0000049_abnormal_middle_ear0.94048279
107MP0005319_abnormal_enzyme/_coenzyme0.93458388
108MP0005551_abnormal_eye_electrophysiolog0.92656792
109MP0009780_abnormal_chondrocyte_physiolo0.92019933
110MP0002822_catalepsy0.91791141
111MP0009643_abnormal_urine_homeostasis0.91348488
112MP0003984_embryonic_growth_retardation0.90606180
113MP0001661_extended_life_span0.90054041
114MP0002088_abnormal_embryonic_growth/wei0.89241163
115MP0002084_abnormal_developmental_patter0.88602984
116MP0001756_abnormal_urination0.86206353
117MP0008057_abnormal_DNA_replication0.85120592
118MP0003252_abnormal_bile_duct0.84043228
119MP0002751_abnormal_autonomic_nervous0.83986822
120MP0009745_abnormal_behavioral_response0.83837348
121MP0002078_abnormal_glucose_homeostasis0.83597829
122MP0002736_abnormal_nociception_after0.83573014
123MP0000631_abnormal_neuroendocrine_gland0.83316496
124MP0002210_abnormal_sex_determination0.82976575
125MP0005584_abnormal_enzyme/coenzyme_acti0.82864793
126MP0003566_abnormal_cell_adhesion0.82509759
127MP0002971_abnormal_brown_adipose0.82504131
128MP0005646_abnormal_pituitary_gland0.82129417
129MP0003828_pulmonary_edema0.81666324
130MP0002090_abnormal_vision0.81374424
131MP0003786_premature_aging0.80827105
132MP0000778_abnormal_nervous_system0.79800690
133MP0001177_atelectasis0.77881142
134MP0002233_abnormal_nose_morphology0.77790150
135MP0004957_abnormal_blastocyst_morpholog0.77544435
136MP0005380_embryogenesis_phenotype0.76101844
137MP0001672_abnormal_embryogenesis/_devel0.76101844
138MP0004147_increased_porphyrin_level0.75709258
139MP0001929_abnormal_gametogenesis0.75248454
140MP0003635_abnormal_synaptic_transmissio0.74846822
141MP0003329_amyloid_beta_deposits0.74288085
142MP0004859_abnormal_synaptic_plasticity0.71342624
143MP0002118_abnormal_lipid_homeostasis0.70945590
144MP0009672_abnormal_birth_weight0.70584230
145MP0005535_abnormal_body_temperature0.70053735
146MP0000358_abnormal_cell_content/0.69534818
147MP0001697_abnormal_embryo_size0.69438648
148MP0008875_abnormal_xenobiotic_pharmacok0.68970671
149MP0000230_abnormal_systemic_arterial0.68774231
150MP0002080_prenatal_lethality0.67700940
151MP0009840_abnormal_foam_cell0.65779503
152MP0003195_calcinosis0.63507138
153MP0004197_abnormal_fetal_growth/weight/0.62665038
154MP0001765_abnormal_ion_homeostasis0.62509405
155MP0005083_abnormal_biliary_tract0.60248445
156MP0005165_increased_susceptibility_to0.59056188
157MP0002970_abnormal_white_adipose0.58289796
158MP0001666_abnormal_nutrient_absorption0.57445283
159MP0003119_abnormal_digestive_system0.55239238
160MP0002086_abnormal_extraembryonic_tissu0.55067705
161MP0003122_maternal_imprinting0.52501251
162MP0001849_ear_inflammation0.52175007

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.29145976
2Myoglobinuria (HP:0002913)4.83443842
3Exercise-induced muscle cramps (HP:0003710)4.78308090
4Exercise-induced myalgia (HP:0003738)4.25687874
5Ventricular tachycardia (HP:0004756)4.00935244
6Rhabdomyolysis (HP:0003201)3.91179777
7Ketoacidosis (HP:0001993)3.81003930
8Palpitations (HP:0001962)3.71681945
9Right ventricular cardiomyopathy (HP:0011663)3.48583256
10Hypoglycemic coma (HP:0001325)3.46928432
11Calf muscle hypertrophy (HP:0008981)3.43350111
12Atrial fibrillation (HP:0005110)3.32180806
13Bundle branch block (HP:0011710)3.26715050
14Lipoatrophy (HP:0100578)3.22967485
15Ventricular fibrillation (HP:0001663)3.19935655
16Primary atrial arrhythmia (HP:0001692)3.14420716
17Conjunctival hamartoma (HP:0100780)3.12814939
18Ragged-red muscle fibers (HP:0003200)3.11660322
19Hyperglycinuria (HP:0003108)3.09160813
20Supraventricular tachycardia (HP:0004755)3.09045794
21Abnormality of the left ventricular outflow tract (HP:0011103)3.08961220
22Subaortic stenosis (HP:0001682)3.08961220
23Ketosis (HP:0001946)3.07309203
24Supraventricular arrhythmia (HP:0005115)3.06181174
25Abnormality of fatty-acid metabolism (HP:0004359)3.06026120
26Abnormality of the calf musculature (HP:0001430)3.05642663
27Muscle fiber splitting (HP:0003555)3.04374360
28Muscle hypertrophy of the lower extremities (HP:0008968)3.03628131
29Syncope (HP:0001279)2.99599797
30Hepatic necrosis (HP:0002605)2.99089352
31Ventricular arrhythmia (HP:0004308)2.92215433
32Colon cancer (HP:0003003)2.87902687
33Hyperammonemia (HP:0001987)2.87081420
34Abnormality of the labia minora (HP:0012880)2.86861299
35Increased serum pyruvate (HP:0003542)2.86382655
36Abnormality of glycolysis (HP:0004366)2.86382655
37Pheochromocytoma (HP:0002666)2.84474967
38Abnormal mitochondria in muscle tissue (HP:0008316)2.78045486
39Hyporeflexia of lower limbs (HP:0002600)2.77927688
40Neoplasm of the adrenal gland (HP:0100631)2.77482311
41Dicarboxylic aciduria (HP:0003215)2.76546719
42Abnormality of dicarboxylic acid metabolism (HP:0010995)2.76546719
43Gout (HP:0001997)2.73206205
44Dilated cardiomyopathy (HP:0001644)2.73083847
45Increased hepatocellular lipid droplets (HP:0006565)2.72990948
46Abnormality of serum amino acid levels (HP:0003112)2.71819928
47Increased connective tissue (HP:0009025)2.71013626
48Abnormality of serine family amino acid metabolism (HP:0010894)2.69074214
49Abnormality of glycine metabolism (HP:0010895)2.69074214
50Lipid accumulation in hepatocytes (HP:0006561)2.65751099
51Asymmetric septal hypertrophy (HP:0001670)2.64992009
52Angiofibromas (HP:0010615)2.60034892
53Adenoma sebaceum (HP:0009720)2.60034892
54Prolonged QT interval (HP:0001657)2.59789431
55Hamartoma of the eye (HP:0010568)2.58973590
56Increased serum lactate (HP:0002151)2.58452304
57EMG: myopathic abnormalities (HP:0003458)2.58189376
58Difficulty running (HP:0009046)2.56502889
59Acute encephalopathy (HP:0006846)2.54442707
60Atrioventricular block (HP:0001678)2.53929511
61Cerebral edema (HP:0002181)2.53252074
62Dysmetric saccades (HP:0000641)2.51867378
63Increased intramyocellular lipid droplets (HP:0012240)2.51367404
64Neuroendocrine neoplasm (HP:0100634)2.47629570
65Heart block (HP:0012722)2.46941494
66Myotonia (HP:0002486)2.45929921
67Multiple enchondromatosis (HP:0005701)2.44405812
68Hepatocellular necrosis (HP:0001404)2.41942652
69Acute necrotizing encephalopathy (HP:0006965)2.40697844
70Methylmalonic acidemia (HP:0002912)2.40598868
71Limb-girdle muscle atrophy (HP:0003797)2.38577476
72Lymphangioma (HP:0100764)2.35336799
73Athetosis (HP:0002305)2.34874169
74Abnormality of alanine metabolism (HP:0010916)2.33677420
75Hyperalaninemia (HP:0003348)2.33677420
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33677420
77Exercise intolerance (HP:0003546)2.30176726
78Increased muscle lipid content (HP:0009058)2.28887793
79Generalized aminoaciduria (HP:0002909)2.27510635
80Muscle stiffness (HP:0003552)2.27117018
81Difficulty climbing stairs (HP:0003551)2.25808505
82Abnormal atrioventricular conduction (HP:0005150)2.24764038
83Methylmalonic aciduria (HP:0012120)2.22229773
84Myokymia (HP:0002411)2.20991048
85Lactic acidosis (HP:0003128)2.20938294
86Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19931015
87Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19931015
88Neoplasm of the peripheral nervous system (HP:0100007)2.14806403
89Increased CSF lactate (HP:0002490)2.14618271
90Proximal tubulopathy (HP:0000114)2.13914370
91Birth length less than 3rd percentile (HP:0003561)2.08355168
92Abnormal lung lobation (HP:0002101)2.06836176
93Reticulocytopenia (HP:0001896)2.06264851
94Hyperglycinemia (HP:0002154)2.05005049
95Increased purine levels (HP:0004368)2.03140952
96Hyperuricemia (HP:0002149)2.03140952
97Renal Fanconi syndrome (HP:0001994)2.02274976
98Leukodystrophy (HP:0002415)2.02082563
99Progressive macrocephaly (HP:0004481)2.01517425
100Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98983486
101Resting tremor (HP:0002322)1.98726907
102Metabolic acidosis (HP:0001942)1.98594129
103Stenosis of the external auditory canal (HP:0000402)1.98042983
104Microvesicular hepatic steatosis (HP:0001414)1.97568139
105Nemaline bodies (HP:0003798)1.97279817
106Rimmed vacuoles (HP:0003805)1.96519982
107Ependymoma (HP:0002888)1.96174110
108Esophageal neoplasm (HP:0100751)1.95590354
109Neoplasm of head and neck (HP:0012288)1.95590354
110Muscle fiber inclusion bodies (HP:0100299)1.94681300
111Abnormal EKG (HP:0003115)1.94485384
112Chromsome breakage (HP:0040012)1.93321869
113Lethargy (HP:0001254)1.92198625
114Chromosomal breakage induced by crosslinking agents (HP:0003221)1.91330987
115Mitochondrial inheritance (HP:0001427)1.91134080
116Neoplasm of the rectum (HP:0100743)1.90554488
117Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.88136774
118Cavernous hemangioma (HP:0001048)1.86482840
119Respiratory failure (HP:0002878)1.85989611
120Nausea (HP:0002018)1.85362176
121Late onset (HP:0003584)1.83454062
122Meckel diverticulum (HP:0002245)1.83402757
123Abnormality of the lower motor neuron (HP:0002366)1.82517314
124Type 1 muscle fiber predominance (HP:0003803)1.81649850
125Neonatal death (HP:0003811)1.81386500
126Abnormality of the vocal cords (HP:0008777)1.79840361
127Optic disc pallor (HP:0000543)1.79125485
128CNS demyelination (HP:0007305)1.79117534
129Cerebral hypomyelination (HP:0006808)1.77184253
130CNS hypomyelination (HP:0003429)1.76806121
131Abnormality of the ileum (HP:0001549)1.76018026
132Type I transferrin isoform profile (HP:0003642)1.75473171
133Aplasia/Hypoplasia of the uvula (HP:0010293)1.73673673
134Abnormality of chromosome stability (HP:0003220)1.71371248
135Hypoplastic pelvis (HP:0008839)1.65082153
136Abnormality of urine glucose concentration (HP:0011016)1.63956093
137Glycosuria (HP:0003076)1.63956093
138Medial flaring of the eyebrow (HP:0010747)1.63845356
139Cortical dysplasia (HP:0002539)1.63438684
140Abnormality of aspartate family amino acid metabolism (HP:0010899)1.60746828
141Abnormality of cells of the erythroid lineage (HP:0012130)1.59103128
142Abnormality of methionine metabolism (HP:0010901)1.57724667
143Reduced antithrombin III activity (HP:0001976)1.57468993
144Poor suck (HP:0002033)1.55338782
145Abnormal number of erythroid precursors (HP:0012131)1.54986834
146Failure to thrive in infancy (HP:0001531)1.54138612
147Shoulder girdle muscle weakness (HP:0003547)1.53632952
148Abnormal protein glycosylation (HP:0012346)1.50741792
149Abnormal glycosylation (HP:0012345)1.50741792
150Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.50741792
151Abnormal protein N-linked glycosylation (HP:0012347)1.50741792
152Hyperinsulinemic hypoglycemia (HP:0000825)1.50424523
153Gait imbalance (HP:0002141)1.49689957
154Gonadotropin excess (HP:0000837)1.49620518
155Abnormality of the vitamin B12 metabolism (HP:0004341)1.47437761
156Congenital primary aphakia (HP:0007707)1.45543554
157X-linked dominant inheritance (HP:0001423)1.44923792
158Vaginal atresia (HP:0000148)1.44574539
159Neoplasm of the colon (HP:0100273)1.44318296

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.71816897
2PKN24.31940526
3TRIB34.13669860
4LMTK24.01174969
5PDK33.61755727
6PDK43.61755727
7TTN3.44510683
8BCKDK3.04252783
9SRPK12.49808492
10OBSCN2.31660289
11VRK22.25256320
12PBK2.23263170
13ZAK2.21533053
14STK162.21160780
15PHKG12.17313735
16PHKG22.17313735
17MYLK2.07080857
18SCYL21.95073791
19TRIM281.93276473
20CDK191.88433841
21EEF2K1.85963577
22PLK41.83016153
23PDK21.81215479
24RIPK11.65674790
25PLK31.62033319
26MKNK11.61131269
27EIF2AK31.54420632
28CSNK1G31.44496276
29PLK11.42749284
30CSNK1G21.40663942
31CSNK1G11.34464046
32KSR21.34218628
33BCR1.33262531
34VRK11.32615854
35TLK11.32564395
36TAF11.29985228
37WNK41.27297814
38EPHA41.25929266
39CSNK1A1L1.24233498
40WNK31.23417560
41MAP3K101.21472294
42BMPR1B1.19479255
43ATR1.19015846
44PLK21.18879038
45DYRK21.16161845
46FLT31.14895351
47MAP2K71.08975162
48MKNK21.08876735
49MARK11.07555748
50DMPK1.07148330
51NUAK11.06271368
52MAP4K21.06094770
53CASK1.04274351
54ILK1.04259494
55TSSK60.99393399
56STK240.98919205
57PTK60.97594993
58PAK30.97302242
59KSR10.94558128
60MAP3K40.93330040
61PDGFRA0.93285455
62WEE10.93044458
63CDC70.90787888
64GRK10.90742349
65MAP3K90.90159250
66MAP3K120.89898039
67MINK10.89735384
68ACVR1B0.88766641
69OXSR10.88038780
70ERBB30.87923182
71MAP2K40.87468392
72MAPKAPK30.84585479
73LATS20.83857623
74LRRK20.82549040
75ALK0.81111526
76STK380.80441659
77PAK40.80096800
78STK38L0.79041571
79PRKD30.76911226
80AURKA0.76224748
81SIK10.75973467
82MAP3K70.75928742
83CHEK20.75622676
84PAK60.75572434
85TTK0.75352406
86TESK10.74547877
87RPS6KB20.73331090
88PIK3CA0.72627833
89PRKAA10.72027707
90MST40.72015369
91BUB10.71443334
92TNIK0.71023936
93ATM0.70787819
94CAMKK10.70452628
95PINK10.70137923
96BRSK10.68444950
97DAPK30.68113160
98TGFBR10.67404367
99RET0.65757119
100MAP2K30.64925306
101CDC42BPA0.64726330
102MAP3K80.61280532
103STK390.61233106
104PRKCG0.60269598
105MAP3K50.60059898
106CDK40.58413191
107AKT20.58161174
108PNCK0.57457321
109MAPK130.57429750
110ROCK10.57188557
111LIMK10.55666945
112CHEK10.53922969
113CDK140.53838276
114FER0.53824734
115PASK0.53474845
116DAPK10.53354796
117CSNK1E0.53108704
118CAMK2A0.53023171
119CSNK2A10.52692740
120PRKDC0.52331929
121MAP2K10.51555404
122FGFR10.51307118
123CDK180.51215734
124CSNK2A20.49955882
125CDK11A0.48794239
126NEK20.48777094
127NME10.48374288
128NME20.48157189
129CDK150.47619804
130PRKD10.46805784
131MTOR0.46647851
132EIF2AK20.46535506
133DAPK20.45916193
134TAOK10.45226182
135TIE10.44673778
136CSNK1A10.43259489
137PIM20.42548783
138RPS6KA50.41848889
139CDK20.40829882
140MAP3K110.40035264
141CDK70.40004717
142PRKCE0.39843541
143CDK10.39364203
144SGK30.36767454
145EIF2AK10.36239574
146MAPK110.34539628
147PDK10.34460290
148CCNB10.33966730
149CAMK2D0.33945260
150AURKB0.32024248
151PRKACG0.31685085
152MAPK120.31069717
153PDPK10.30611273
154BRSK20.29951103
155STK40.29389100
156PRKACB0.29282652
157PRKG20.29186598
158CAMK40.27292983
159ROCK20.26636822
160NTRK30.26568475
161MAP3K20.26420300
162MAP3K30.23591536
163PAK20.23050213
164CAMK1D0.22265792

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.25075476
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012105.00034767
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38235874
4Propanoate metabolism_Homo sapiens_hsa006403.16089215
5Carbon metabolism_Homo sapiens_hsa012003.04862152
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.80167868
7Fatty acid degradation_Homo sapiens_hsa000712.79307507
8Proteasome_Homo sapiens_hsa030502.58931376
9Pyruvate metabolism_Homo sapiens_hsa006202.54576918
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.53284864
11Cardiac muscle contraction_Homo sapiens_hsa042602.27400518
12Biosynthesis of amino acids_Homo sapiens_hsa012302.23098321
13Fatty acid metabolism_Homo sapiens_hsa012122.12029191
14Butanoate metabolism_Homo sapiens_hsa006502.10135851
15Non-homologous end-joining_Homo sapiens_hsa034502.07878003
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.02773792
17Parkinsons disease_Homo sapiens_hsa050121.83507119
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79427076
19Base excision repair_Homo sapiens_hsa034101.77249879
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75636590
21Protein export_Homo sapiens_hsa030601.74254422
22Ribosome_Homo sapiens_hsa030101.73498562
23Nitrogen metabolism_Homo sapiens_hsa009101.71700596
24RNA polymerase_Homo sapiens_hsa030201.71160782
25Homologous recombination_Homo sapiens_hsa034401.63537715
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60900256
27Nucleotide excision repair_Homo sapiens_hsa034201.59894615
28* Oxidative phosphorylation_Homo sapiens_hsa001901.58006551
29Dilated cardiomyopathy_Homo sapiens_hsa054141.50227713
30Arginine biosynthesis_Homo sapiens_hsa002201.46832842
31Fanconi anemia pathway_Homo sapiens_hsa034601.36909295
32Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36388808
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35826371
34Steroid biosynthesis_Homo sapiens_hsa001001.33732251
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32976084
36RNA degradation_Homo sapiens_hsa030181.27229461
37Tryptophan metabolism_Homo sapiens_hsa003801.22332744
38Spliceosome_Homo sapiens_hsa030401.22289567
39PPAR signaling pathway_Homo sapiens_hsa033201.19251389
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.16886647
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13878486
42Sulfur relay system_Homo sapiens_hsa041221.13273342
43Alzheimers disease_Homo sapiens_hsa050101.11337862
44Pyrimidine metabolism_Homo sapiens_hsa002401.10580442
45Vitamin B6 metabolism_Homo sapiens_hsa007501.10137676
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08951280
47Basal transcription factors_Homo sapiens_hsa030221.06379877
48Huntingtons disease_Homo sapiens_hsa050161.05916641
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05643705
50Fructose and mannose metabolism_Homo sapiens_hsa000511.04811432
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.04613552
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01199129
53Glucagon signaling pathway_Homo sapiens_hsa049221.01023352
54Cell cycle_Homo sapiens_hsa041101.00334300
55beta-Alanine metabolism_Homo sapiens_hsa004100.99118087
56Purine metabolism_Homo sapiens_hsa002300.97778499
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96359919
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93718049
59Pentose phosphate pathway_Homo sapiens_hsa000300.91527498
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91344840
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90028575
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.89044050
63Starch and sucrose metabolism_Homo sapiens_hsa005000.88097097
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87292622
65Bile secretion_Homo sapiens_hsa049760.86311613
66Galactose metabolism_Homo sapiens_hsa000520.83992701
67Insulin signaling pathway_Homo sapiens_hsa049100.80035987
68Lysine degradation_Homo sapiens_hsa003100.77165414
69Insulin resistance_Homo sapiens_hsa049310.75828030
70Peroxisome_Homo sapiens_hsa041460.74411127
71AMPK signaling pathway_Homo sapiens_hsa041520.73476699
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72330464
73Nicotine addiction_Homo sapiens_hsa050330.72224958
74Selenocompound metabolism_Homo sapiens_hsa004500.71073709
75Folate biosynthesis_Homo sapiens_hsa007900.63891069
76mRNA surveillance pathway_Homo sapiens_hsa030150.63232912
77Phototransduction_Homo sapiens_hsa047440.62515517
78Phenylalanine metabolism_Homo sapiens_hsa003600.62126162
79Fat digestion and absorption_Homo sapiens_hsa049750.61677088
80Fatty acid biosynthesis_Homo sapiens_hsa000610.56603698
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.55417061
82Arginine and proline metabolism_Homo sapiens_hsa003300.54444101
83Gastric acid secretion_Homo sapiens_hsa049710.54243690
84One carbon pool by folate_Homo sapiens_hsa006700.53223975
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51298364
86Vitamin digestion and absorption_Homo sapiens_hsa049770.49599494
87Glycerolipid metabolism_Homo sapiens_hsa005610.48247420
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47515556
89HIF-1 signaling pathway_Homo sapiens_hsa040660.46141518
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45951628
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45623337
92Viral myocarditis_Homo sapiens_hsa054160.44233289
93Oocyte meiosis_Homo sapiens_hsa041140.43924011
94mTOR signaling pathway_Homo sapiens_hsa041500.43822612
95Sulfur metabolism_Homo sapiens_hsa009200.43798184
96Fatty acid elongation_Homo sapiens_hsa000620.43206607
97Type II diabetes mellitus_Homo sapiens_hsa049300.41565252
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.41039391
99Tight junction_Homo sapiens_hsa045300.40136400
100Retinol metabolism_Homo sapiens_hsa008300.39048157
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38708125
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38695064
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38181315
104Synaptic vesicle cycle_Homo sapiens_hsa047210.37602792
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37325478
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36929557
107DNA replication_Homo sapiens_hsa030300.35865902
108Chemical carcinogenesis_Homo sapiens_hsa052040.34151507
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33538504
110Collecting duct acid secretion_Homo sapiens_hsa049660.32713006
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32074484
112Caffeine metabolism_Homo sapiens_hsa002320.31414378
113Long-term potentiation_Homo sapiens_hsa047200.30111804
114Insulin secretion_Homo sapiens_hsa049110.30036272
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.29041823
116GABAergic synapse_Homo sapiens_hsa047270.28845775
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28691041
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28672421
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27885984
120Gap junction_Homo sapiens_hsa045400.27731951
121Oxytocin signaling pathway_Homo sapiens_hsa049210.27534819
122* Metabolic pathways_Homo sapiens_hsa011000.27314273
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26899677
124Linoleic acid metabolism_Homo sapiens_hsa005910.26863051
125N-Glycan biosynthesis_Homo sapiens_hsa005100.26554598
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26069638
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.24218916
128Taste transduction_Homo sapiens_hsa047420.23756461
129Glutathione metabolism_Homo sapiens_hsa004800.23348892
130Thyroid hormone synthesis_Homo sapiens_hsa049180.23163909
131Tyrosine metabolism_Homo sapiens_hsa003500.21793631
132Mismatch repair_Homo sapiens_hsa034300.21004396
133RNA transport_Homo sapiens_hsa030130.20476843
134Renin secretion_Homo sapiens_hsa049240.19490537
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.16849750
136Thyroid cancer_Homo sapiens_hsa052160.16069647
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14646127
138Estrogen signaling pathway_Homo sapiens_hsa049150.14457931
139Focal adhesion_Homo sapiens_hsa045100.14087943
140Dopaminergic synapse_Homo sapiens_hsa047280.13723573
141Calcium signaling pathway_Homo sapiens_hsa040200.13455875

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