ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	indolalkylamine metabolic process (GO:0006586)	4.84110564
2	indole-containing compound catabolic process (GO:0042436)	4.64122760
3	indolalkylamine catabolic process (GO:0046218)	4.64122760
4	tryptophan catabolic process (GO:0006569)	4.64122760
5	neural tube formation (GO:0001841)	4.29870204
6	protein K11-linked deubiquitination (GO:0035871)	4.29297158
7	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.28635963
8	kynurenine metabolic process (GO:0070189)	4.13244636
9	photoreceptor cell maintenance (GO:0045494)	4.08617266
10	tryptophan metabolic process (GO:0006568)	4.08547955
11	detection of light stimulus involved in sensory perception (GO:0050962)	3.89728138
12	detection of light stimulus involved in visual perception (GO:0050908)	3.89728138
13	tachykinin receptor signaling pathway (GO:0007217)	3.81906508
14	signal peptide processing (GO:0006465)	3.80262469
15	behavioral response to ethanol (GO:0048149)	3.59722299
16	establishment of protein localization to Golgi (GO:0072600)	3.57629845
17	dopamine transport (GO:0015872)	3.56346672
18	response to pheromone (GO:0019236)	3.55306310
19	sphingoid metabolic process (GO:0046519)	3.52300921
20	cellular ketone body metabolic process (GO:0046950)	3.42591506
21	reflex (GO:0060004)	3.41152647
22	indole-containing compound metabolic process (GO:0042430)	3.39015617
23	monoubiquitinated protein deubiquitination (GO:0035520)	3.38232953
24	regulation of protein glycosylation (GO:0060049)	3.36021693
25	gamma-aminobutyric acid transport (GO:0015812)	3.35177026
26	positive regulation of developmental pigmentation (GO:0048087)	3.32695985
27	cellular biogenic amine catabolic process (GO:0042402)	3.30593722
28	amine catabolic process (GO:0009310)	3.30593722
29	cilium or flagellum-dependent cell motility (GO:0001539)	3.26331979
30	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.25487004
31	retinal cone cell development (GO:0046549)	3.16972733
32	DNA methylation involved in gamete generation (GO:0043046)	3.16418037
33	rRNA catabolic process (GO:0016075)	3.15660328
34	prenylation (GO:0097354)	3.15647094
35	protein prenylation (GO:0018342)	3.15647094
36	oxidative demethylation (GO:0070989)	3.15174285
37	protein K48-linked deubiquitination (GO:0071108)	3.14953667
38	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.14026551
39	regulation of meiosis I (GO:0060631)	3.13441988
40	L-fucose catabolic process (GO:0042355)	3.13312323
41	fucose catabolic process (GO:0019317)	3.13312323
42	L-fucose metabolic process (GO:0042354)	3.13312323
43	piRNA metabolic process (GO:0034587)	3.12712086
44	regulation of hippo signaling (GO:0035330)	3.12342311
45	regulation of pigment cell differentiation (GO:0050932)	3.05636515
46	ketone body metabolic process (GO:1902224)	3.01021500
47	benzene-containing compound metabolic process (GO:0042537)	3.00010728
48	auditory receptor cell stereocilium organization (GO:0060088)	2.98715397
49	reciprocal DNA recombination (GO:0035825)	2.97031872
50	reciprocal meiotic recombination (GO:0007131)	2.97031872
51	aromatic amino acid family catabolic process (GO:0009074)	2.96031670
52	NAD biosynthetic process (GO:0009435)	2.95514155
53	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.93658946
54	axoneme assembly (GO:0035082)	2.89932593
55	negative regulation of mast cell activation (GO:0033004)	2.87365762
56	cilium morphogenesis (GO:0060271)	2.86332696
57	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.86038313
58	proline transport (GO:0015824)	2.84937728
59	acrosome assembly (GO:0001675)	2.84696313
60	protein targeting to Golgi (GO:0000042)	2.84273959
61	protein K63-linked deubiquitination (GO:0070536)	2.83608029
62	regulation of sarcomere organization (GO:0060297)	2.83122960
63	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.82649814
64	aromatic amino acid family metabolic process (GO:0009072)	2.81611308
65	inner ear receptor stereocilium organization (GO:0060122)	2.78574053
66	behavioral response to nicotine (GO:0035095)	2.72920000
67	serotonin metabolic process (GO:0042428)	2.70235823
68	cellular response to sterol (GO:0036315)	2.66756751
69	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.65400511
70	meiotic chromosome segregation (GO:0045132)	2.63460366
71	centriole replication (GO:0007099)	2.62474099
72	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.61685322
73	central nervous system neuron axonogenesis (GO:0021955)	2.60584841
74	transmission of nerve impulse (GO:0019226)	2.60516361
75	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.59574349
76	presynaptic membrane assembly (GO:0097105)	2.57186060
77	multicellular organism reproduction (GO:0032504)	2.55676168
78	primary amino compound metabolic process (GO:1901160)	2.54476851
79	thyroid hormone metabolic process (GO:0042403)	2.53757921
80	protein targeting to vacuole (GO:0006623)	2.53568296
81	protein targeting to lysosome (GO:0006622)	2.53568296
82	establishment of protein localization to vacuole (GO:0072666)	2.53568296
83	glycosphingolipid biosynthetic process (GO:0006688)	2.53008191
84	sphingosine metabolic process (GO:0006670)	2.52262352
85	nonmotile primary cilium assembly (GO:0035058)	2.52081088
86	cilium organization (GO:0044782)	2.50767206
87	neuronal action potential (GO:0019228)	2.49708823
88	pyrimidine nucleobase catabolic process (GO:0006208)	2.49674467
89	regulation of collateral sprouting (GO:0048670)	2.48737329
90	platelet dense granule organization (GO:0060155)	2.48539557
91	startle response (GO:0001964)	2.47848118
92	protein-chromophore linkage (GO:0018298)	2.47661917
93	cilium assembly (GO:0042384)	2.47366907
94	regulation of cilium movement (GO:0003352)	2.47141226
95	negative regulation of cAMP-mediated signaling (GO:0043951)	2.46465161
96	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.46250582
97	flavonoid metabolic process (GO:0009812)	2.45805554
98	anterograde synaptic vesicle transport (GO:0048490)	2.43763683
99	righting reflex (GO:0060013)	2.42666482
100	visual perception (GO:0007601)	2.41445451

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.51978037
2	ZNF274_21170338_ChIP-Seq_K562_Hela	2.96024966
3	VDR_22108803_ChIP-Seq_LS180_Human	2.90350170
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.75829459
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.69708834
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.68937730
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.52823676
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.49961862
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.44034260
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.41387906
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.37977055
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.32016216
13	P300_19829295_ChIP-Seq_ESCs_Human	2.30552369
14	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.17133571
15	ER_23166858_ChIP-Seq_MCF-7_Human	2.12373431
16	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.11545778
17	FUS_26573619_Chip-Seq_HEK293_Human	2.02926535
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.99658598
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.98322852
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.94151001
21	STAT3_23295773_ChIP-Seq_U87_Human	1.91010824
22	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.87134296
23	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.86082904
24	EWS_26573619_Chip-Seq_HEK293_Human	1.85057522
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.84916296
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.81840181
27	AR_21572438_ChIP-Seq_LNCaP_Human	1.78852272
28	EZH2_22144423_ChIP-Seq_EOC_Human	1.78720111
29	TCF4_23295773_ChIP-Seq_U87_Human	1.75707873
30	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.75353718
31	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.74534700
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.71629594
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.67486745
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.67486745
35	AR_25329375_ChIP-Seq_VCAP_Human	1.62006295
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.61373634
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.58436055
38	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.55081382
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.54964314
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53800601
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.53800601
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.53425800
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.53237888
44	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.52033364
45	TCF4_22108803_ChIP-Seq_LS180_Human	1.50716858
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.47287152
47	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.46865716
48	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.41966080
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.41384475
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.41044767
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.41044767
52	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.40449095
53	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.39470146
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.38603477
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.37361505
56	CDX2_22108803_ChIP-Seq_LS180_Human	1.36768336
57	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.34772561
58	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.33777015
59	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.33630971
60	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.33302625
61	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.32998006
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.32523288
63	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.31400137
64	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.28815508
65	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.27199307
66	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.27013683
67	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.26257616
68	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25347091
69	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.24274461
70	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.23554560
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.21393400
72	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.20646170
73	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.20333425
74	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.19428418
75	TP53_22573176_ChIP-Seq_HFKS_Human	1.19415054
76	P53_22387025_ChIP-Seq_ESCs_Mouse	1.17381573
77	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.14715702
78	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.14033144
79	TP53_16413492_ChIP-PET_HCT116_Human	1.13651685
80	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.11978706
81	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11288709
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11079585
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11079585
84	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.10578937
85	KDM2B_26808549_Chip-Seq_REH_Human	1.10286554
86	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.10058525
87	REST_21632747_ChIP-Seq_MESCs_Mouse	1.09488837
88	P300_18555785_Chip-Seq_ESCs_Mouse	1.09131336
89	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.09109078
90	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.08384991
91	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.06763550
92	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.05757277
93	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.04257517
94	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.03830421
95	IRF1_19129219_ChIP-ChIP_H3396_Human	1.02527480
96	CJUN_26792858_Chip-Seq_BT549_Human	1.01576729
97	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.00951400
98	AHR_22903824_ChIP-Seq_MCF-7_Human	0.99558369
99	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98319655
100	DROSHA_22980978_ChIP-Seq_HELA_Human	0.98204559

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.36820363
2	MP0003195_calcinosis	3.51311786
3	MP0005551_abnormal_eye_electrophysiolog	2.76404724
4	MP0008057_abnormal_DNA_replication	2.72974580
5	MP0002837_dystrophic_cardiac_calcinosis	2.70634301
6	MP0008877_abnormal_DNA_methylation	2.64950736
7	MP0002736_abnormal_nociception_after	2.63495001
8	MP0001968_abnormal_touch/_nociception	2.61445367
9	MP0001501_abnormal_sleep_pattern	2.46662052
10	MP0003136_yellow_coat_color	2.42118206
11	MP0009046_muscle_twitch	2.35053003
12	MP0005171_absent_coat_pigmentation	2.30362090
13	MP0004147_increased_porphyrin_level	2.22715742
14	MP0002102_abnormal_ear_morphology	2.12407355
15	MP0003646_muscle_fatigue	2.04118354
16	MP0000427_abnormal_hair_cycle	2.02316396
17	MP0009745_abnormal_behavioral_response	1.98556454
18	MP0001486_abnormal_startle_reflex	1.94199449
19	MP0003787_abnormal_imprinting	1.94066347
20	MP0003880_abnormal_central_pattern	1.93093686
21	MP0006054_spinal_hemorrhage	1.88326524
22	MP0008872_abnormal_physiological_respon	1.87921005
23	MP0001984_abnormal_olfaction	1.85920352
24	MP0002653_abnormal_ependyma_morphology	1.76904416
25	MP0001986_abnormal_taste_sensitivity	1.74621841
26	MP0004043_abnormal_pH_regulation	1.71226578
27	MP0006276_abnormal_autonomic_nervous	1.63894125
28	MP0005253_abnormal_eye_physiology	1.62690118
29	MP0005646_abnormal_pituitary_gland	1.56990850
30	MP0005670_abnormal_white_adipose	1.54674663
31	MP0002272_abnormal_nervous_system	1.50347257
32	MP0003950_abnormal_plasma_membrane	1.45527712
33	MP0001485_abnormal_pinna_reflex	1.44302377
34	MP0004924_abnormal_behavior	1.34409998
35	MP0005386_behavior/neurological_phenoty	1.34409998
36	MP0002572_abnormal_emotion/affect_behav	1.29400276
37	MP0006072_abnormal_retinal_apoptosis	1.29127174
38	MP0001970_abnormal_pain_threshold	1.29088095
39	MP0003635_abnormal_synaptic_transmissio	1.27812262
40	MP0002735_abnormal_chemical_nociception	1.27453599
41	MP0005174_abnormal_tail_pigmentation	1.26222369
42	MP0005085_abnormal_gallbladder_physiolo	1.25985934
43	MP0002138_abnormal_hepatobiliary_system	1.25776070
44	MP0002733_abnormal_thermal_nociception	1.24693189
45	MP0005310_abnormal_salivary_gland	1.22061610
46	MP0004484_altered_response_of	1.21328773
47	MP0005075_abnormal_melanosome_morpholog	1.20516942
48	MP0002876_abnormal_thyroid_physiology	1.19732253
49	MP0000372_irregular_coat_pigmentation	1.19019010
50	MP0004142_abnormal_muscle_tone	1.18853653
51	MP0002938_white_spotting	1.17212994
52	MP0002064_seizures	1.16714451
53	MP0003183_abnormal_peptide_metabolism	1.15600379
54	MP0002067_abnormal_sensory_capabilities	1.15079137
55	MP0005410_abnormal_fertilization	1.14763516
56	MP0002928_abnormal_bile_duct	1.13363581
57	MP0003718_maternal_effect	1.13018567
58	MP0002229_neurodegeneration	1.12826522
59	MP0004885_abnormal_endolymph	1.11172237
60	MP0004215_abnormal_myocardial_fiber	1.10807174
61	MP0002095_abnormal_skin_pigmentation	1.09418543
62	MP0003045_fibrosis	1.07012969
63	MP0003252_abnormal_bile_duct	1.02690781
64	MP0001764_abnormal_homeostasis	1.01920320
65	MP0003011_delayed_dark_adaptation	1.01810889
66	MP0002557_abnormal_social/conspecific_i	0.98479318
67	MP0004742_abnormal_vestibular_system	0.97634759
68	MP0005266_abnormal_metabolism	0.96849227
69	MP0003698_abnormal_male_reproductive	0.95918644
70	MP0000371_diluted_coat_color	0.93327607
71	MP0005360_urolithiasis	0.91351965
72	MP0010386_abnormal_urinary_bladder	0.90585813
73	MP0003633_abnormal_nervous_system	0.89467666
74	MP0000383_abnormal_hair_follicle	0.89413737
75	MP0002063_abnormal_learning/memory/cond	0.89261982
76	MP0003890_abnormal_embryonic-extraembry	0.88910953
77	MP0000015_abnormal_ear_pigmentation	0.88152138
78	MP0002168_other_aberrant_phenotype	0.85869537
79	MP0002751_abnormal_autonomic_nervous	0.85500274
80	MP0002734_abnormal_mechanical_nocicepti	0.84887489
81	MP0004381_abnormal_hair_follicle	0.84660363
82	MP0005195_abnormal_posterior_eye	0.84634128
83	MP0008058_abnormal_DNA_repair	0.84264574
84	MP0005395_other_phenotype	0.83882283
85	MP0002752_abnormal_somatic_nervous	0.83793152
86	MP0000631_abnormal_neuroendocrine_gland	0.83593383
87	MP0005645_abnormal_hypothalamus_physiol	0.81837753
88	MP0001963_abnormal_hearing_physiology	0.81666932
89	MP0003879_abnormal_hair_cell	0.81528212
90	MP0001529_abnormal_vocalization	0.81005603
91	MP0001324_abnormal_eye_pigmentation	0.80837816
92	MP0000230_abnormal_systemic_arterial	0.79287581
93	MP0002234_abnormal_pharynx_morphology	0.79085916
94	MP0009780_abnormal_chondrocyte_physiolo	0.78890955
95	MP0004085_abnormal_heartbeat	0.77676265
96	MP0003137_abnormal_impulse_conducting	0.76324330
97	MP0005423_abnormal_somatic_nervous	0.75135377
98	MP0008875_abnormal_xenobiotic_pharmacok	0.74544484
99	MP0002132_abnormal_respiratory_system	0.74217901
100	MP0002638_abnormal_pupillary_reflex	0.74189257

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.47583687
2	Gaze-evoked nystagmus (HP:0000640)	4.08530201
3	Pancreatic fibrosis (HP:0100732)	3.98231390
4	True hermaphroditism (HP:0010459)	3.79803867
5	Hyperventilation (HP:0002883)	3.71671830
6	Protruding tongue (HP:0010808)	3.51501992
7	Genetic anticipation (HP:0003743)	3.40258359
8	Attenuation of retinal blood vessels (HP:0007843)	3.35836160
9	Molar tooth sign on MRI (HP:0002419)	3.31786691
10	Abnormality of midbrain morphology (HP:0002418)	3.31786691
11	Abnormality of the renal cortex (HP:0011035)	3.29784932
12	Progressive cerebellar ataxia (HP:0002073)	3.12808068
13	Absent speech (HP:0001344)	3.05376547
14	Febrile seizures (HP:0002373)	3.02535020
15	Medial flaring of the eyebrow (HP:0010747)	2.98318461
16	Nephronophthisis (HP:0000090)	2.98003112
17	Congenital stationary night blindness (HP:0007642)	2.96195821
18	Abnormality of the renal medulla (HP:0100957)	2.89597436
19	Chronic hepatic failure (HP:0100626)	2.89480214
20	Bony spicule pigmentary retinopathy (HP:0007737)	2.87148696
21	Focal motor seizures (HP:0011153)	2.85236523
22	Cystic liver disease (HP:0006706)	2.82113120
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.71235592
24	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.70565510
25	Abnormality of alanine metabolism (HP:0010916)	2.70565510
26	Hyperalaninemia (HP:0003348)	2.70565510
27	Type II lissencephaly (HP:0007260)	2.70017272
28	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.66160086
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.57416859
30	Pendular nystagmus (HP:0012043)	2.57162268
31	Fair hair (HP:0002286)	2.57071958
32	Congenital sensorineural hearing impairment (HP:0008527)	2.56331530
33	Gait imbalance (HP:0002141)	2.55439955
34	Abnormality of macular pigmentation (HP:0008002)	2.55361520
35	Congenital primary aphakia (HP:0007707)	2.53275916
36	Inability to walk (HP:0002540)	2.52105153
37	Abolished electroretinogram (ERG) (HP:0000550)	2.50081212
38	Dialeptic seizures (HP:0011146)	2.49246576
39	Focal seizures (HP:0007359)	2.49174905
40	Abnormal biliary tract physiology (HP:0012439)	2.48638504
41	Bile duct proliferation (HP:0001408)	2.48638504
42	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.46375685
43	Decreased central vision (HP:0007663)	2.43199677
44	Renal cortical cysts (HP:0000803)	2.39993479
45	Intestinal atresia (HP:0011100)	2.38246764
46	Progressive inability to walk (HP:0002505)	2.34645641
47	Nephrogenic diabetes insipidus (HP:0009806)	2.29715838
48	Hypoplastic iliac wings (HP:0002866)	2.28765508
49	Widely spaced teeth (HP:0000687)	2.28065446
50	Generalized hypopigmentation of hair (HP:0011358)	2.27468825
51	Stomach cancer (HP:0012126)	2.25792636
52	Large for gestational age (HP:0001520)	2.24973084
53	Cerebellar dysplasia (HP:0007033)	2.24625093
54	Thyroid-stimulating hormone excess (HP:0002925)	2.23421819
55	Sclerocornea (HP:0000647)	2.22932552
56	Genital tract atresia (HP:0001827)	2.20482805
57	Lissencephaly (HP:0001339)	2.20245809
58	Retinitis pigmentosa (HP:0000510)	2.20188217
59	Congenital hepatic fibrosis (HP:0002612)	2.18450376
60	Acanthocytosis (HP:0001927)	2.17186793
61	Tubular atrophy (HP:0000092)	2.14236233
62	Central scotoma (HP:0000603)	2.13734851
63	Furrowed tongue (HP:0000221)	2.12963112
64	Increased corneal curvature (HP:0100692)	2.11184702
65	Keratoconus (HP:0000563)	2.11184702
66	Broad-based gait (HP:0002136)	2.06579835
67	Vaginal atresia (HP:0000148)	2.03699720
68	Amelogenesis imperfecta (HP:0000705)	2.03648492
69	Polydipsia (HP:0001959)	2.00384394
70	Abnormal drinking behavior (HP:0030082)	2.00384394
71	Anencephaly (HP:0002323)	1.99341699
72	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.94347432
73	Hypoplasia of the fovea (HP:0007750)	1.94347432
74	Poor coordination (HP:0002370)	1.92258168
75	Abnormality of the labia minora (HP:0012880)	1.92168552
76	Hypothermia (HP:0002045)	1.90559362
77	Volvulus (HP:0002580)	1.87293859
78	Constricted visual fields (HP:0001133)	1.86665005
79	Macular degeneration (HP:0000608)	1.85279315
80	Short foot (HP:0001773)	1.84627454
81	Decreased circulating renin level (HP:0003351)	1.82710198
82	Retinal dysplasia (HP:0007973)	1.80816114
83	Astigmatism (HP:0000483)	1.78781686
84	Clumsiness (HP:0002312)	1.77998794
85	Abnormality of dental color (HP:0011073)	1.77106575
86	Male pseudohermaphroditism (HP:0000037)	1.75702068
87	Occipital encephalocele (HP:0002085)	1.75597408
88	Optic nerve hypoplasia (HP:0000609)	1.75366430
89	Abnormal ciliary motility (HP:0012262)	1.72784577
90	Drooling (HP:0002307)	1.72257050
91	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.71994931
92	Severe visual impairment (HP:0001141)	1.70392964
93	Facial diplegia (HP:0001349)	1.69231552
94	Abnormal protein glycosylation (HP:0012346)	1.69223454
95	Abnormal glycosylation (HP:0012345)	1.69223454
96	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.69223454
97	Abnormal protein N-linked glycosylation (HP:0012347)	1.69223454
98	Polyuria (HP:0000103)	1.69094933
99	Postaxial foot polydactyly (HP:0001830)	1.68011227
100	Narrow forehead (HP:0000341)	1.67183610

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.79010023
2	INSRR	3.42028396
3	CASK	3.00750778
4	ACVR1B	2.81821400
5	STK38L	2.70731961
6	WNK3	2.42318564
7	MAP4K2	2.40836801
8	ADRBK2	2.38076333
9	BMPR1B	2.21383924
10	LATS1	2.15821674
11	PINK1	2.06906126
12	MAP3K4	1.78653948
13	TNIK	1.73627926
14	MAPK13	1.68571371
15	ZAK	1.67353763
16	GRK1	1.60739542
17	PDK2	1.57016588
18	OXSR1	1.54578808
19	MST4	1.51335043
20	NUAK1	1.47065750
21	PIK3CG	1.46124926
22	MARK1	1.40335769
23	MUSK	1.38691909
24	ADRBK1	1.31537755
25	MKNK2	1.29976261
26	TAOK3	1.28622829
27	STK3	1.27323005
28	STK39	1.24565262
29	TRIM28	1.21758716
30	PTK2B	1.14905917
31	STK38	1.12513608
32	NTRK3	1.10037396
33	PRKCE	1.03150944
34	CAMKK2	0.98302669
35	PAK3	0.95894471
36	DAPK2	0.91049829
37	PLK2	0.90428500
38	TNK2	0.90215497
39	NLK	0.90175006
40	AKT3	0.81536045
41	FER	0.81406082
42	ERBB3	0.79383804
43	BRSK2	0.78524529
44	BLK	0.76386709
45	BCR	0.74236361
46	TEC	0.72996750
47	MAP2K7	0.72621879
48	PRKCG	0.71874038
49	EPHA4	0.71862342
50	GRK5	0.65552869
51	MKNK1	0.63245353
52	MARK3	0.63115761
53	EIF2AK3	0.61391452
54	MAP3K12	0.60941181
55	BMPR2	0.60754822
56	WNK4	0.59807760
57	CAMK2A	0.55137018
58	TXK	0.55045942
59	CSNK1A1L	0.54786372
60	SGK2	0.54783746
61	PRKAA2	0.53072974
62	TGFBR1	0.50551819
63	FGFR2	0.48447355
64	CSNK1G1	0.44496636
65	MAP2K4	0.44152025
66	PIK3CA	0.43892361
67	CCNB1	0.39733515
68	CSNK1D	0.38849314
69	CSNK1G2	0.38159356
70	PKN1	0.38042575
71	DYRK2	0.36899473
72	PLK3	0.34999602
73	DYRK3	0.34507436
74	PRKACA	0.33542630
75	PRKCI	0.33270785
76	STK11	0.32618908
77	CSNK1G3	0.32304404
78	IRAK1	0.32085834
79	MAPKAPK5	0.31631448
80	ERBB2	0.31509833
81	CAMK4	0.29761196
82	DYRK1A	0.28747069
83	TRPM7	0.28721743
84	MELK	0.28714265
85	YES1	0.28427135
86	ERBB4	0.28320213
87	MAP3K2	0.26962757
88	PRKACB	0.26774960
89	CSNK1A1	0.26578372
90	PLK4	0.26256446
91	PRKCQ	0.25734202
92	ABL1	0.24862819
93	MAP3K7	0.24169915
94	RPS6KA5	0.23981835
95	PRKCB	0.23019512
96	CDK3	0.22780396
97	CLK1	0.22402916
98	PNCK	0.21743162
99	ITK	0.21257051
100	SGK1	0.20911415

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.24844861
2	Phototransduction_Homo sapiens_hsa04744	3.14053990
3	Butanoate metabolism_Homo sapiens_hsa00650	3.00927820
4	Nicotine addiction_Homo sapiens_hsa05033	2.60351388
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.47206101
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.47086671
7	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.38086708
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.22175234
9	Tryptophan metabolism_Homo sapiens_hsa00380	2.16355263
10	Taste transduction_Homo sapiens_hsa04742	2.07631656
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.03607690
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.01554517
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.97520861
14	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.93377359
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.85996482
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.85482562
17	Propanoate metabolism_Homo sapiens_hsa00640	1.78959614
18	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.76032156
19	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.75653545
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.74177195
21	ABC transporters_Homo sapiens_hsa02010	1.69919280
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.69549966
23	Caffeine metabolism_Homo sapiens_hsa00232	1.67717880
24	Olfactory transduction_Homo sapiens_hsa04740	1.56887613
25	Non-homologous end-joining_Homo sapiens_hsa03450	1.54163340
26	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.53761441
27	Morphine addiction_Homo sapiens_hsa05032	1.51188961
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.45578514
29	Retinol metabolism_Homo sapiens_hsa00830	1.44547316
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.36611377
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.35160082
32	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.34060289
33	Glutamatergic synapse_Homo sapiens_hsa04724	1.30219572
34	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.29819358
35	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.28568629
36	Basal transcription factors_Homo sapiens_hsa03022	1.26855764
37	beta-Alanine metabolism_Homo sapiens_hsa00410	1.21664242
38	Homologous recombination_Homo sapiens_hsa03440	1.16909173
39	Sphingolipid metabolism_Homo sapiens_hsa00600	1.16370205
40	GABAergic synapse_Homo sapiens_hsa04727	1.13221387
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.12342831
42	Serotonergic synapse_Homo sapiens_hsa04726	1.11244594
43	Circadian entrainment_Homo sapiens_hsa04713	1.09929687
44	Peroxisome_Homo sapiens_hsa04146	1.08216771
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.07590990
46	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.01667949
47	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.01106319
48	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.99496380
49	Regulation of autophagy_Homo sapiens_hsa04140	0.98102845
50	Calcium signaling pathway_Homo sapiens_hsa04020	0.98078254
51	Fanconi anemia pathway_Homo sapiens_hsa03460	0.97592651
52	Fatty acid degradation_Homo sapiens_hsa00071	0.94696431
53	Insulin secretion_Homo sapiens_hsa04911	0.94294177
54	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.91582453
55	Histidine metabolism_Homo sapiens_hsa00340	0.90687804
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.89578933
57	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.88487223
58	Salivary secretion_Homo sapiens_hsa04970	0.87474310
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.85120828
60	Long-term depression_Homo sapiens_hsa04730	0.80652617
61	Dopaminergic synapse_Homo sapiens_hsa04728	0.76758098
62	Fatty acid metabolism_Homo sapiens_hsa01212	0.70417196
63	One carbon pool by folate_Homo sapiens_hsa00670	0.69476314
64	Lysine degradation_Homo sapiens_hsa00310	0.67706199
65	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.65059845
66	RNA degradation_Homo sapiens_hsa03018	0.64446172
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64234266
68	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.62250628
69	Amphetamine addiction_Homo sapiens_hsa05031	0.62250138
70	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.60696360
71	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.58650969
72	Protein export_Homo sapiens_hsa03060	0.57681916
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54926547
74	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.51650145
75	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.50109922
76	Cocaine addiction_Homo sapiens_hsa05030	0.49351231
77	cAMP signaling pathway_Homo sapiens_hsa04024	0.48874528
78	Cholinergic synapse_Homo sapiens_hsa04725	0.48202804
79	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.47541286
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.46068326
81	Gastric acid secretion_Homo sapiens_hsa04971	0.45786665
82	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.43342001
83	Metabolic pathways_Homo sapiens_hsa01100	0.42001005
84	Circadian rhythm_Homo sapiens_hsa04710	0.41247412
85	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.40374150
86	PPAR signaling pathway_Homo sapiens_hsa03320	0.39504411
87	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.38641002
88	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.38025698
89	Renin secretion_Homo sapiens_hsa04924	0.37024578
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.35565689
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.35229899
92	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.35194881
93	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.33337788
94	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.29938166
95	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.29545734
96	Type II diabetes mellitus_Homo sapiens_hsa04930	0.28338740
97	Mineral absorption_Homo sapiens_hsa04978	0.26302045
98	Sulfur relay system_Homo sapiens_hsa04122	0.25796377
99	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.25348113
100	Purine metabolism_Homo sapiens_hsa00230	0.25079453

ATP5A1P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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