ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.99302394
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	7.91941372
3	ribosomal small subunit assembly (GO:0000028)	7.89984002
4	translational termination (GO:0006415)	7.70610188
5	ATP synthesis coupled proton transport (GO:0015986)	7.60948890
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	7.60948890
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.80064826
8	cotranslational protein targeting to membrane (GO:0006613)	6.79573553
9	protein targeting to ER (GO:0045047)	6.73588365
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.46559442
11	translational elongation (GO:0006414)	6.34534452
12	protein localization to endoplasmic reticulum (GO:0070972)	6.33370529
13	cellular protein complex disassembly (GO:0043624)	5.90429580
14	ribosomal small subunit biogenesis (GO:0042274)	5.81462318
15	viral life cycle (GO:0019058)	5.64590822
16	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.51585986
17	maturation of SSU-rRNA (GO:0030490)	5.50508819
18	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.47911434
19	respiratory electron transport chain (GO:0022904)	5.33191539
20	electron transport chain (GO:0022900)	5.24728111
21	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.17133478
22	translational initiation (GO:0006413)	5.15466240
23	ribosomal large subunit biogenesis (GO:0042273)	4.98451751
24	protein complex disassembly (GO:0043241)	4.98393876
25	chaperone-mediated protein transport (GO:0072321)	4.90784112
26	macromolecular complex disassembly (GO:0032984)	4.76233969
27	protein targeting to membrane (GO:0006612)	4.55170841
28	translation (GO:0006412)	4.24162027
29	ATP biosynthetic process (GO:0006754)	4.23936236
30	protein neddylation (GO:0045116)	4.21392975
31	behavioral response to nicotine (GO:0035095)	4.20863627
32	hydrogen ion transmembrane transport (GO:1902600)	4.10244211
33	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.08812517
34	protein complex biogenesis (GO:0070271)	4.03322466
35	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.01173366
36	NADH dehydrogenase complex assembly (GO:0010257)	4.01173366
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.01173366
38	mRNA catabolic process (GO:0006402)	3.86230183
39	sequestering of actin monomers (GO:0042989)	3.83546886
40	proton transport (GO:0015992)	3.73640698
41	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.68946196
42	mitochondrial respiratory chain complex assembly (GO:0033108)	3.67030412
43	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.66825900
44	hydrogen transport (GO:0006818)	3.66450291
45	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.52952460
46	protein-cofactor linkage (GO:0018065)	3.52627401
47	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.52447333
48	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.52447333
49	RNA catabolic process (GO:0006401)	3.49999347
50	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.43045210
51	establishment of protein localization to membrane (GO:0090150)	3.19507490
52	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.18243058
53	cellular component biogenesis (GO:0044085)	3.12105404
54	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.09037618
55	protein targeting (GO:0006605)	3.01381821
56	ribonucleoprotein complex biogenesis (GO:0022613)	2.97011031
57	DNA deamination (GO:0045006)	2.90614190
58	positive regulation of respiratory burst (GO:0060267)	2.90270936
59	intracellular protein transmembrane import (GO:0044743)	2.90071210
60	nucleoside triphosphate biosynthetic process (GO:0009142)	2.88490958
61	nonmotile primary cilium assembly (GO:0035058)	2.84149686
62	water-soluble vitamin biosynthetic process (GO:0042364)	2.83135505
63	regulation of cellular respiration (GO:0043457)	2.81239662
64	chromatin remodeling at centromere (GO:0031055)	2.74724541
65	epithelial cilium movement (GO:0003351)	2.73558075
66	neuron fate determination (GO:0048664)	2.73250967
67	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.69297667
68	establishment of protein localization to organelle (GO:0072594)	2.69083521
69	aldehyde catabolic process (GO:0046185)	2.64387676
70	kynurenine metabolic process (GO:0070189)	2.63497989
71	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.61603999
72	termination of RNA polymerase III transcription (GO:0006386)	2.61603999
73	platelet dense granule organization (GO:0060155)	2.60460320
74	CENP-A containing nucleosome assembly (GO:0034080)	2.59153440
75	respiratory chain complex IV assembly (GO:0008535)	2.52078920
76	organelle disassembly (GO:1903008)	2.50138429
77	protein localization to membrane (GO:0072657)	2.47891834
78	spliceosomal complex assembly (GO:0000245)	2.47485989
79	oxidative phosphorylation (GO:0006119)	2.46057706
80	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.42817786
81	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.42817786
82	endoderm formation (GO:0001706)	2.40867989
83	positive regulation of prostaglandin secretion (GO:0032308)	2.40746282
84	indole-containing compound catabolic process (GO:0042436)	2.40261571
85	indolalkylamine catabolic process (GO:0046218)	2.40261571
86	tryptophan catabolic process (GO:0006569)	2.40261571
87	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.38823580
88	cytochrome complex assembly (GO:0017004)	2.36741950
89	centriole replication (GO:0007099)	2.36735624
90	cardiovascular system development (GO:0072358)	2.36699464
91	peptidyl-histidine modification (GO:0018202)	2.34093516
92	indolalkylamine metabolic process (GO:0006586)	2.33102977
93	negative regulation of heart rate (GO:0010459)	2.32378958
94	establishment of protein localization to mitochondrion (GO:0072655)	2.31669250
95	protein targeting to mitochondrion (GO:0006626)	2.31379484
96	GPI anchor metabolic process (GO:0006505)	2.31344695
97	pseudouridine synthesis (GO:0001522)	2.31077151
98	pyrimidine nucleobase catabolic process (GO:0006208)	2.28059866
99	cilium movement (GO:0003341)	2.26804049
100	mitochondrial transport (GO:0006839)	2.25173188

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.33992291
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.04278078
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.81501387
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.51856677
5	VDR_22108803_ChIP-Seq_LS180_Human	3.28412105
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.22864193
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.06195273
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.43778367
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.20594552
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.16662862
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.13566502
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.12558181
13	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.09240978
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.04405793
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.02658978
16	VDR_23849224_ChIP-Seq_CD4+_Human	1.96384441
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.89656510
18	MYC_18940864_ChIP-ChIP_HL60_Human	1.87736250
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.78755303
20	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.78604132
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.77064453
22	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.76466799
23	FUS_26573619_Chip-Seq_HEK293_Human	1.72822975
24	EWS_26573619_Chip-Seq_HEK293_Human	1.72179552
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.71746478
26	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.69923470
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.69520341
28	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.68561114
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.67683055
30	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.60049936
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.58746623
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.57858433
33	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.51564054
34	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.49349954
35	GBX2_23144817_ChIP-Seq_PC3_Human	1.48248723
36	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.42011268
37	P300_19829295_ChIP-Seq_ESCs_Human	1.41140645
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40204643
39	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.39769005
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.38124126
41	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.38095644
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37827813
43	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.36686072
44	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.36599041
45	RNF2_27304074_Chip-Seq_NSC_Mouse	1.35656002
46	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.35099417
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.31687134
48	IGF1R_20145208_ChIP-Seq_DFB_Human	1.29891423
49	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29248769
50	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.23826836
51	NCOR_22424771_ChIP-Seq_293T_Human	1.22603150
52	NANOG_20526341_ChIP-Seq_ESCs_Human	1.22329389
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20361450
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20361450
55	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.20194286
56	XRN2_22483619_ChIP-Seq_HELA_Human	1.18463369
57	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.18077266
58	AR_20517297_ChIP-Seq_VCAP_Human	1.17166243
59	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.15146706
60	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.14631970
61	ER_23166858_ChIP-Seq_MCF-7_Human	1.14402959
62	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.14142407
63	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.13029635
64	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.12759567
65	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12336170
66	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12336170
67	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11995120
68	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.11060550
69	IRF1_19129219_ChIP-ChIP_H3396_Human	1.10544910
70	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.08919256
71	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07885518
72	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07381279
73	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04951177
74	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03409534
75	REST_21632747_ChIP-Seq_MESCs_Mouse	1.02602044
76	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.02468284
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00979501
78	ERG_20517297_ChIP-Seq_VCAP_Human	1.00117128
79	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.00081362
80	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.00018386
81	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.99801280
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98805805
83	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.98532892
84	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98337997
85	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.98088315
86	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97187910
87	MYC_19829295_ChIP-Seq_ESCs_Human	0.94883901
88	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.94293919
89	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.94151228
90	ERA_21632823_ChIP-Seq_H3396_Human	0.94080692
91	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.94015536
92	CBP_20019798_ChIP-Seq_JUKART_Human	0.94015536
93	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.93929321
94	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.93469621
95	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.86970757
96	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.86890177
97	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.85524505
98	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.85498659
99	TCF4_22108803_ChIP-Seq_LS180_Human	0.85494029
100	GABP_19822575_ChIP-Seq_HepG2_Human	0.83397438

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.37642411
2	MP0006292_abnormal_olfactory_placode	3.24699203
3	MP0000569_abnormal_digit_pigmentation	2.76579426
4	MP0005377_hearing/vestibular/ear_phenot	2.47613221
5	MP0003878_abnormal_ear_physiology	2.47613221
6	MP0004142_abnormal_muscle_tone	2.43912656
7	MP0002938_white_spotting	2.41165430
8	MP0000566_synostosis	2.31001492
9	MP0006072_abnormal_retinal_apoptosis	2.21954229
10	MP0003787_abnormal_imprinting	2.06802417
11	MP0008789_abnormal_olfactory_epithelium	1.97241761
12	MP0003880_abnormal_central_pattern	1.96594699
13	MP0005174_abnormal_tail_pigmentation	1.94217374
14	MP0002653_abnormal_ependyma_morphology	1.87960212
15	MP0003122_maternal_imprinting	1.87650193
16	MP0004145_abnormal_muscle_electrophysio	1.84898287
17	MP0008877_abnormal_DNA_methylation	1.81135848
18	MP0005551_abnormal_eye_electrophysiolog	1.74268630
19	MP0005084_abnormal_gallbladder_morpholo	1.72583058
20	MP0002095_abnormal_skin_pigmentation	1.71942303
21	MP0003121_genomic_imprinting	1.70965294
22	MP0004742_abnormal_vestibular_system	1.65981672
23	MP0001293_anophthalmia	1.65033082
24	MP0005671_abnormal_response_to	1.63866136
25	MP0004885_abnormal_endolymph	1.61107154
26	MP0002277_abnormal_respiratory_mucosa	1.60477900
27	MP0006276_abnormal_autonomic_nervous	1.59458612
28	MP0001905_abnormal_dopamine_level	1.58644256
29	MP0002638_abnormal_pupillary_reflex	1.56815436
30	MP0003123_paternal_imprinting	1.53212198
31	MP0008872_abnormal_physiological_respon	1.49104306
32	MP0005394_taste/olfaction_phenotype	1.48133471
33	MP0005499_abnormal_olfactory_system	1.48133471
34	MP0001485_abnormal_pinna_reflex	1.47368529
35	MP0002837_dystrophic_cardiac_calcinosis	1.46750109
36	MP0004133_heterotaxia	1.46494300
37	MP0002272_abnormal_nervous_system	1.44368966
38	MP0009745_abnormal_behavioral_response	1.43047124
39	MP0001968_abnormal_touch/_nociception	1.40086524
40	MP0009046_muscle_twitch	1.39712901
41	MP0002102_abnormal_ear_morphology	1.35131624
42	MP0000631_abnormal_neuroendocrine_gland	1.35010940
43	MP0001984_abnormal_olfaction	1.32388755
44	MP0010030_abnormal_orbit_morphology	1.32065195
45	MP0005075_abnormal_melanosome_morpholog	1.28660102
46	MP0002736_abnormal_nociception_after	1.26980423
47	MP0001529_abnormal_vocalization	1.26892637
48	MP0002876_abnormal_thyroid_physiology	1.21025580
49	MP0000049_abnormal_middle_ear	1.16479739
50	MP0001970_abnormal_pain_threshold	1.13556649
51	MP0008875_abnormal_xenobiotic_pharmacok	1.12514663
52	MP0000427_abnormal_hair_cycle	1.12437067
53	MP0002734_abnormal_mechanical_nocicepti	1.07422805
54	MP0003011_delayed_dark_adaptation	1.07066523
55	MP0005195_abnormal_posterior_eye	1.06918849
56	MP0000026_abnormal_inner_ear	1.05134158
57	MP0002557_abnormal_social/conspecific_i	1.05025966
58	MP0000372_irregular_coat_pigmentation	1.04820578
59	MP0002234_abnormal_pharynx_morphology	1.04190024
60	MP0003136_yellow_coat_color	1.03005637
61	MP0001324_abnormal_eye_pigmentation	1.01258769
62	MP0002733_abnormal_thermal_nociception	1.00581176
63	MP0004147_increased_porphyrin_level	1.00212216
64	MP0003646_muscle_fatigue	0.98990175
65	MP0000778_abnormal_nervous_system	0.98769099
66	MP0001440_abnormal_grooming_behavior	0.98556861
67	MP0001986_abnormal_taste_sensitivity	0.97085624
68	MP0008995_early_reproductive_senescence	0.96969746
69	MP0005253_abnormal_eye_physiology	0.95865825
70	MP0002572_abnormal_emotion/affect_behav	0.95309530
71	MP0002067_abnormal_sensory_capabilities	0.94976188
72	MP0009764_decreased_sensitivity_to	0.94655034
73	MP0002752_abnormal_somatic_nervous	0.93262364
74	MP0005423_abnormal_somatic_nervous	0.93149756
75	MP0005360_urolithiasis	0.90522273
76	MP0001188_hyperpigmentation	0.89974922
77	MP0001963_abnormal_hearing_physiology	0.89431881
78	MP0003195_calcinosis	0.88877839
79	MP0001286_abnormal_eye_development	0.88031646
80	MP0005645_abnormal_hypothalamus_physiol	0.86202812
81	MP0008961_abnormal_basal_metabolism	0.82120082
82	MP0005389_reproductive_system_phenotype	0.81560563
83	MP0003938_abnormal_ear_development	0.80581988
84	MP0002064_seizures	0.79346075
85	MP0003806_abnormal_nucleotide_metabolis	0.78449186
86	MP0001835_abnormal_antigen_presentation	0.76258805
87	MP0003283_abnormal_digestive_organ	0.74846219
88	MP0001486_abnormal_startle_reflex	0.73785701
89	MP0002233_abnormal_nose_morphology	0.73428798
90	MP0002163_abnormal_gland_morphology	0.72934185
91	MP0003186_abnormal_redox_activity	0.72320620
92	MP0000955_abnormal_spinal_cord	0.71205761
93	MP0005646_abnormal_pituitary_gland	0.70791534
94	MP0003937_abnormal_limbs/digits/tail_de	0.69853389
95	MP0005332_abnormal_amino_acid	0.69595488
96	MP0009250_abnormal_appendicular_skeleto	0.69503155
97	MP0002822_catalepsy	0.69329836
98	MP0002735_abnormal_chemical_nociception	0.68601016
99	MP0002063_abnormal_learning/memory/cond	0.68600533
100	MP0001919_abnormal_reproductive_system	0.68166683

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.16339891
2	Acute necrotizing encephalopathy (HP:0006965)	4.51886677
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.30490203
4	Macrocytic anemia (HP:0001972)	4.29719841
5	Mitochondrial inheritance (HP:0001427)	3.97897524
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.90971544
7	Congenital, generalized hypertrichosis (HP:0004540)	3.80044962
8	Acute encephalopathy (HP:0006846)	3.75221459
9	3-Methylglutaconic aciduria (HP:0003535)	3.73016687
10	Progressive macrocephaly (HP:0004481)	3.66963659
11	Abnormal number of erythroid precursors (HP:0012131)	3.64761591
12	Increased CSF lactate (HP:0002490)	3.58946840
13	Increased hepatocellular lipid droplets (HP:0006565)	3.51500070
14	Pancreatic fibrosis (HP:0100732)	3.49180881
15	Pallor (HP:0000980)	3.46277900
16	Hepatocellular necrosis (HP:0001404)	3.34586844
17	Abnormality of midbrain morphology (HP:0002418)	3.33107386
18	Molar tooth sign on MRI (HP:0002419)	3.33107386
19	Lipid accumulation in hepatocytes (HP:0006561)	3.20101346
20	Pancreatic cysts (HP:0001737)	3.18526219
21	Hepatic necrosis (HP:0002605)	3.14265745
22	Optic disc pallor (HP:0000543)	3.07490930
23	Congenital stationary night blindness (HP:0007642)	3.03914364
24	Nephronophthisis (HP:0000090)	2.99086226
25	Cerebral edema (HP:0002181)	2.90588468
26	Medial flaring of the eyebrow (HP:0010747)	2.86342851
27	Renal Fanconi syndrome (HP:0001994)	2.85636822
28	Myokymia (HP:0002411)	2.80900793
29	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.80108924
30	Abnormality of alanine metabolism (HP:0010916)	2.80108924
31	Hyperalaninemia (HP:0003348)	2.80108924
32	True hermaphroditism (HP:0010459)	2.79257908
33	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.73780938
34	Abnormal ciliary motility (HP:0012262)	2.57621599
35	Stenosis of the external auditory canal (HP:0000402)	2.56683800
36	Methylmalonic acidemia (HP:0002912)	2.53232096
37	Exertional dyspnea (HP:0002875)	2.48179678
38	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.45343786
39	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.45343786
40	Limb dystonia (HP:0002451)	2.41824941
41	Methylmalonic aciduria (HP:0012120)	2.41030080
42	Abnormality of the renal medulla (HP:0100957)	2.36305382
43	Abnormal respiratory epithelium morphology (HP:0012253)	2.34419064
44	Abnormal respiratory motile cilium morphology (HP:0005938)	2.34419064
45	Sclerocornea (HP:0000647)	2.34418759
46	Lactic acidosis (HP:0003128)	2.33960104
47	Abnormal rod and cone electroretinograms (HP:0008323)	2.33768245
48	Increased intramyocellular lipid droplets (HP:0012240)	2.33137350
49	Depressed nasal ridge (HP:0000457)	2.31106762
50	Increased serum lactate (HP:0002151)	2.29377792
51	Abolished electroretinogram (ERG) (HP:0000550)	2.28489370
52	Abnormal respiratory motile cilium physiology (HP:0012261)	2.27428210
53	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.25005984
54	Abnormality of the labia minora (HP:0012880)	2.23503345
55	Hypothermia (HP:0002045)	2.23337402
56	Aplastic anemia (HP:0001915)	2.22326100
57	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.21643053
58	Hypoplasia of the pons (HP:0012110)	2.18338071
59	Leukodystrophy (HP:0002415)	2.17612170
60	Abnormality of renal resorption (HP:0011038)	2.15136519
61	IgG deficiency (HP:0004315)	2.10023791
62	Gait imbalance (HP:0002141)	2.08440212
63	Abnormality of the pons (HP:0007361)	2.06672076
64	Anencephaly (HP:0002323)	2.06631380
65	Chronic hepatic failure (HP:0100626)	2.05799734
66	Absent thumb (HP:0009777)	2.05419310
67	Type II lissencephaly (HP:0007260)	2.03928467
68	Constricted visual fields (HP:0001133)	2.01969735
69	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.01417540
70	Absent/shortened dynein arms (HP:0200106)	2.01417540
71	Congenital primary aphakia (HP:0007707)	1.98678648
72	Abnormality of the renal cortex (HP:0011035)	1.96941169
73	Lethargy (HP:0001254)	1.95950954
74	Retinal dysplasia (HP:0007973)	1.95121139
75	Abnormality of serum amino acid levels (HP:0003112)	1.94941121
76	Myotonia (HP:0002486)	1.93859247
77	Colon cancer (HP:0003003)	1.93623373
78	Type 2 muscle fiber atrophy (HP:0003554)	1.91439096
79	Nephrogenic diabetes insipidus (HP:0009806)	1.90898178
80	Male pseudohermaphroditism (HP:0000037)	1.90401717
81	Triphalangeal thumb (HP:0001199)	1.90005759
82	Rhinitis (HP:0012384)	1.88684223
83	Elevated erythrocyte sedimentation rate (HP:0003565)	1.86736276
84	Increased muscle lipid content (HP:0009058)	1.85665505
85	Septo-optic dysplasia (HP:0100842)	1.85277364
86	Bony spicule pigmentary retinopathy (HP:0007737)	1.83797873
87	Respiratory difficulties (HP:0002880)	1.82172510
88	Maternal diabetes (HP:0009800)	1.81924271
89	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.80962243
90	Rib fusion (HP:0000902)	1.80686212
91	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.78415366
92	Progressive cerebellar ataxia (HP:0002073)	1.78384485
93	Attenuation of retinal blood vessels (HP:0007843)	1.77662313
94	Cystic liver disease (HP:0006706)	1.77573740
95	Respiratory failure (HP:0002878)	1.77092149
96	Postaxial foot polydactyly (HP:0001830)	1.76748872
97	Hyperphosphaturia (HP:0003109)	1.76505434
98	Glycosuria (HP:0003076)	1.76360347
99	Abnormality of urine glucose concentration (HP:0011016)	1.76360347
100	Optic nerve hypoplasia (HP:0000609)	1.74215130

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	3.84446789
2	TLK1	3.77974435
3	MAP3K12	2.83755518
4	WNK4	2.65238524
5	MAP4K2	2.57438105
6	TAOK3	2.56688071
7	ZAK	2.33967720
8	WNK3	2.08661142
9	TXK	2.00546555
10	DYRK2	1.99361994
11	GRK1	1.97941375
12	STK16	1.96287217
13	NME1	1.96167476
14	BCKDK	1.81677341
15	ADRBK2	1.80846160
16	NUAK1	1.77121765
17	VRK1	1.69809469
18	MAP2K7	1.59842832
19	VRK2	1.58741598
20	OXSR1	1.56742972
21	CASK	1.48213233
22	MAP3K4	1.46116142
23	BMPR1B	1.31544202
24	CDC7	1.29274199
25	PASK	1.26625892
26	BUB1	1.24908224
27	STK39	1.21486154
28	PINK1	1.17070230
29	MARK1	1.14160934
30	CDK8	1.09052723
31	BMPR2	1.08164692
32	INSRR	1.07318188
33	TESK2	1.06754881
34	NEK2	1.04986365
35	PNCK	1.00429905
36	EPHB2	0.98145756
37	LIMK1	0.96493966
38	PLK4	0.95325619
39	PHKG1	0.93600092
40	PHKG2	0.93600092
41	FRK	0.90365263
42	KIT	0.89395677
43	PDK2	0.89387719
44	TGFBR1	0.88894142
45	MKNK1	0.86003336
46	MYLK	0.85636425
47	SRPK1	0.83780171
48	PRKCQ	0.80769476
49	MKNK2	0.80043358
50	ERBB3	0.79952462
51	ADRBK1	0.76469806
52	TNIK	0.76345393
53	ARAF	0.75618552
54	AURKB	0.75274128
55	PRKCG	0.75058827
56	PIK3CA	0.74984919
57	WEE1	0.72274796
58	RPS6KA5	0.71981660
59	OBSCN	0.70825566
60	TIE1	0.69252366
61	CSNK2A2	0.68403910
62	TEC	0.68390480
63	IKBKB	0.67038527
64	CSNK1G3	0.66836202
65	GRK6	0.65625267
66	KDR	0.64111013
67	TRIM28	0.61093330
68	NEK1	0.60267769
69	DYRK3	0.59741844
70	MAP3K9	0.59036358
71	CSNK1G2	0.58794282
72	MAPK13	0.58665229
73	MAP2K4	0.53026302
74	AURKA	0.52617576
75	ITK	0.51618420
76	DAPK3	0.50571502
77	GRK7	0.48349460
78	MAPK15	0.47694044
79	PLK1	0.47558991
80	SYK	0.47531327
81	STK11	0.47204197
82	MAP2K2	0.47192596
83	PRKACA	0.47081136
84	CSNK2A1	0.46810393
85	MATK	0.45366070
86	PRKCD	0.45010946
87	CSF1R	0.44836851
88	CSNK1G1	0.43723215
89	PLK3	0.42182085
90	PRKG1	0.41473256
91	FLT3	0.41390997
92	PRKCA	0.40273853
93	CAMK1	0.39641116
94	MAP2K6	0.39565578
95	MINK1	0.39378715
96	MUSK	0.39364149
97	PRKACB	0.37575108
98	BTK	0.37444617
99	CDK3	0.37152274
100	EPHA4	0.36484542

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.97306876
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.99330355
3	Parkinsons disease_Homo sapiens_hsa05012	4.16772766
4	Protein export_Homo sapiens_hsa03060	3.33942999
5	Alzheimers disease_Homo sapiens_hsa05010	2.93730169
6	Huntingtons disease_Homo sapiens_hsa05016	2.74981186
7	Asthma_Homo sapiens_hsa05310	2.73752893
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.69111966
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.49563107
10	Proteasome_Homo sapiens_hsa03050	2.37647930
11	RNA polymerase_Homo sapiens_hsa03020	1.98565272
12	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.93027529
13	Basal transcription factors_Homo sapiens_hsa03022	1.88299677
14	Homologous recombination_Homo sapiens_hsa03440	1.56099386
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.49153557
16	Graft-versus-host disease_Homo sapiens_hsa05332	1.47190138
17	Allograft rejection_Homo sapiens_hsa05330	1.46415949
18	Phototransduction_Homo sapiens_hsa04744	1.44271448
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.42575882
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.41859690
21	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.38362100
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.34344970
23	RNA degradation_Homo sapiens_hsa03018	1.30850426
24	Type I diabetes mellitus_Homo sapiens_hsa04940	1.26764694
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.24267614
26	Nicotine addiction_Homo sapiens_hsa05033	1.16148006
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.14251597
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.09242933
29	Rheumatoid arthritis_Homo sapiens_hsa05323	1.05968508
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.03506098
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.03026407
32	Fanconi anemia pathway_Homo sapiens_hsa03460	0.97547152
33	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.97279198
34	Sulfur relay system_Homo sapiens_hsa04122	0.94963793
35	Caffeine metabolism_Homo sapiens_hsa00232	0.92791179
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.89660665
37	Mismatch repair_Homo sapiens_hsa03430	0.89505187
38	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.88471710
39	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87335150
40	Peroxisome_Homo sapiens_hsa04146	0.83045835
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.81283602
42	Propanoate metabolism_Homo sapiens_hsa00640	0.81170616
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.81155147
44	Steroid biosynthesis_Homo sapiens_hsa00100	0.80295229
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80261659
46	Antigen processing and presentation_Homo sapiens_hsa04612	0.79663293
47	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.77911824
48	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.77911574
49	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.77898947
50	Sulfur metabolism_Homo sapiens_hsa00920	0.76423444
51	Regulation of autophagy_Homo sapiens_hsa04140	0.76186227
52	Butanoate metabolism_Homo sapiens_hsa00650	0.75140645
53	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.74675563
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.73848728
55	Pyrimidine metabolism_Homo sapiens_hsa00240	0.73502047
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72503765
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71641106
58	Purine metabolism_Homo sapiens_hsa00230	0.70136799
59	Spliceosome_Homo sapiens_hsa03040	0.64478751
60	Metabolic pathways_Homo sapiens_hsa01100	0.60892657
61	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.60891607
62	Folate biosynthesis_Homo sapiens_hsa00790	0.57895138
63	Olfactory transduction_Homo sapiens_hsa04740	0.55709607
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.54781857
65	Morphine addiction_Homo sapiens_hsa05032	0.54345986
66	Primary immunodeficiency_Homo sapiens_hsa05340	0.53629960
67	One carbon pool by folate_Homo sapiens_hsa00670	0.53338322
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51275835
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50474622
70	Retinol metabolism_Homo sapiens_hsa00830	0.49690452
71	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.49135677
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.45457352
73	DNA replication_Homo sapiens_hsa03030	0.44199386
74	GABAergic synapse_Homo sapiens_hsa04727	0.43750426
75	Taste transduction_Homo sapiens_hsa04742	0.43641270
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43104912
77	Base excision repair_Homo sapiens_hsa03410	0.42813529
78	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42358761
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41347622
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.41143941
81	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.40477056
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.40365929
83	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.39084562
84	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.38828490
85	Basal cell carcinoma_Homo sapiens_hsa05217	0.38514722
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36374427
87	Viral myocarditis_Homo sapiens_hsa05416	0.35544913
88	RNA transport_Homo sapiens_hsa03013	0.35337834
89	Serotonergic synapse_Homo sapiens_hsa04726	0.34587596
90	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33056792
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31828805
92	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.30045479
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.28229197
94	Insulin secretion_Homo sapiens_hsa04911	0.27620604
95	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.27548028
96	Circadian entrainment_Homo sapiens_hsa04713	0.26426158
97	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.26115348
98	Glutamatergic synapse_Homo sapiens_hsa04724	0.23228692
99	Leishmaniasis_Homo sapiens_hsa05140	0.23183801
100	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.22208674

ATP5A1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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