ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.52468532
2	DNA deamination (GO:0045006)	5.20015291
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.15247877
4	ATP synthesis coupled proton transport (GO:0015986)	5.15247877
5	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.06296240
6	proteasome assembly (GO:0043248)	4.98040213
7	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.85520385
8	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.85520385
9	regulation of cilium movement (GO:0003352)	4.73325684
10	chaperone-mediated protein transport (GO:0072321)	4.64545554
11	respiratory electron transport chain (GO:0022904)	4.36093102
12	electron transport chain (GO:0022900)	4.31074919
13	water-soluble vitamin biosynthetic process (GO:0042364)	4.17203068
14	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.02883897
15	positive regulation of defense response to virus by host (GO:0002230)	3.72104578
16	cytidine deamination (GO:0009972)	3.63297215
17	cytidine metabolic process (GO:0046087)	3.63297215
18	cytidine catabolic process (GO:0006216)	3.63297215
19	protein complex biogenesis (GO:0070271)	3.58691013
20	protein-cofactor linkage (GO:0018065)	3.56412893
21	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.48587727
22	base-excision repair, AP site formation (GO:0006285)	3.41673544
23	mitochondrial respiratory chain complex assembly (GO:0033108)	3.40802271
24	iron-sulfur cluster assembly (GO:0016226)	3.40675157
25	metallo-sulfur cluster assembly (GO:0031163)	3.40675157
26	cullin deneddylation (GO:0010388)	3.38461758
27	regulation of defense response to virus by host (GO:0050691)	3.38411291
28	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.37435547
29	oxidative phosphorylation (GO:0006119)	3.37189510
30	regulation of cellular amino acid metabolic process (GO:0006521)	3.35981909
31	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.35914426
32	regulation of oxidative phosphorylation (GO:0002082)	3.34416207
33	protein deneddylation (GO:0000338)	3.33167178
34	hydrogen ion transmembrane transport (GO:1902600)	3.32464216
35	purine deoxyribonucleotide catabolic process (GO:0009155)	3.32298100
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.20350854
37	NADH dehydrogenase complex assembly (GO:0010257)	3.20350854
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.20350854
39	proton transport (GO:0015992)	3.17117805
40	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.16517765
41	hydrogen transport (GO:0006818)	3.12622490
42	peptidyl-histidine modification (GO:0018202)	3.12541412
43	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.11796935
44	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.11796935
45	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.11796935
46	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.10465875
47	ATP biosynthetic process (GO:0006754)	3.08819501
48	signal peptide processing (GO:0006465)	3.06670056
49	aldehyde catabolic process (GO:0046185)	3.05457057
50	ribosomal small subunit assembly (GO:0000028)	3.04215281
51	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.03628029
52	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.00279049
53	cellular response to zinc ion (GO:0071294)	2.98280124
54	respiratory chain complex IV assembly (GO:0008535)	2.97695202
55	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.94426690
56	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.94426690
57	mannosylation (GO:0097502)	2.94094612
58	positive regulation of protein homodimerization activity (GO:0090073)	2.92925697
59	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.92149635
60	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.92149635
61	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.91738282
62	negative regulation of ligase activity (GO:0051352)	2.85947883
63	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.85947883
64	protein K6-linked ubiquitination (GO:0085020)	2.85396549
65	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.84643316
66	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.84025361
67	nonmotile primary cilium assembly (GO:0035058)	2.83139274
68	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.78995853
69	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.78826282
70	protein neddylation (GO:0045116)	2.78304840
71	indolalkylamine metabolic process (GO:0006586)	2.73708811
72	tyrosine metabolic process (GO:0006570)	2.73293393
73	peroxisome fission (GO:0016559)	2.69850215
74	multicellular organism reproduction (GO:0032504)	2.69038877
75	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.67440513
76	cellular response to interleukin-15 (GO:0071350)	2.66951717
77	cellular response to exogenous dsRNA (GO:0071360)	2.66536270
78	negative regulation of heart rate (GO:0010459)	2.66460899
79	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.66360302
80	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.65850324
81	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.65751419
82	fusion of sperm to egg plasma membrane (GO:0007342)	2.65410300
83	regulation of microtubule-based movement (GO:0060632)	2.64285891
84	vitamin biosynthetic process (GO:0009110)	2.64086562
85	cellular ketone body metabolic process (GO:0046950)	2.63191425
86	cellular respiration (GO:0045333)	2.61169943
87	ubiquinone biosynthetic process (GO:0006744)	2.56718362
88	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.56653280
89	photoreceptor cell development (GO:0042461)	2.56342651
90	sleep (GO:0030431)	2.55890265
91	organelle disassembly (GO:1903008)	2.55666879
92	tryptophan metabolic process (GO:0006568)	2.53016291
93	translesion synthesis (GO:0019985)	2.52893562
94	cytochrome complex assembly (GO:0017004)	2.51664352
95	regulation of memory T cell differentiation (GO:0043380)	2.48564812
96	telomere maintenance via semi-conservative replication (GO:0032201)	2.48149811
97	purine deoxyribonucleotide metabolic process (GO:0009151)	2.46934967
98	pseudouridine synthesis (GO:0001522)	2.46835738
99	negative regulation of response to food (GO:0032096)	2.46377632
100	negative regulation of appetite (GO:0032099)	2.46377632

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.35573640
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.10665803
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.53947722
4	FLI1_27457419_Chip-Seq_LIVER_Mouse	3.03631501
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.97882911
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.91710911
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.83601010
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.80367998
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.79576763
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.69453647
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.60827941
12	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.46632323
13	FOXP3_21729870_ChIP-Seq_TREG_Human	2.30037450
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.29603565
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.28805972
16	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.27321953
17	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.26358731
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.25132190
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.21460791
20	VDR_22108803_ChIP-Seq_LS180_Human	2.18264345
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.11281786
22	ELK1_19687146_ChIP-ChIP_HELA_Human	2.03429222
23	TP53_22573176_ChIP-Seq_HFKS_Human	1.86239332
24	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.84963252
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.80814243
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.69880014
27	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.66758138
28	EZH2_22144423_ChIP-Seq_EOC_Human	1.65600887
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.60785336
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.57809529
31	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.57028297
32	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.55114909
33	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.51092750
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.50278780
35	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.48751008
36	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.46487309
37	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.46413300
38	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.44520607
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.42406967
40	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.41656858
41	GATA3_26560356_Chip-Seq_TH2_Human	1.39347254
42	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.37924506
43	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.35650331
44	EWS_26573619_Chip-Seq_HEK293_Human	1.33533117
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32403855
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.31488654
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.31488654
48	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.27432369
49	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.24306514
50	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.21760773
51	GBX2_23144817_ChIP-Seq_PC3_Human	1.20559415
52	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.20494034
53	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.18961408
54	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.18789640
55	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.18072403
56	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.17759137
57	AR_20517297_ChIP-Seq_VCAP_Human	1.17676850
58	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.17518519
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16874127
60	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.14206292
61	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.12555937
62	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.11313550
63	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.09006548
64	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.07722674
65	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07626692
66	BCAT_22108803_ChIP-Seq_LS180_Human	1.07530759
67	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.06988877
68	NCOR_22424771_ChIP-Seq_293T_Human	1.05387527
69	DCP1A_22483619_ChIP-Seq_HELA_Human	1.04896353
70	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.04465916
71	GABP_19822575_ChIP-Seq_HepG2_Human	1.04211703
72	E2F7_22180533_ChIP-Seq_HELA_Human	1.03830813
73	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.03586191
74	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.03458370
75	ERG_20517297_ChIP-Seq_VCAP_Human	1.02853684
76	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.02734885
77	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02701947
78	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.01972275
79	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01479072
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.00571439
81	CBP_20019798_ChIP-Seq_JUKART_Human	1.00571439
82	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.00376804
83	OCT4_20526341_ChIP-Seq_ESCs_Human	0.98582218
84	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98172511
85	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.97470551
86	P53_22387025_ChIP-Seq_ESCs_Mouse	0.97106668
87	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.96015447
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95831449
89	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.95097665
90	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.94828213
91	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.93580563
92	NANOG_19829295_ChIP-Seq_ESCs_Human	0.93250990
93	SOX2_19829295_ChIP-Seq_ESCs_Human	0.93250990
94	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.92764342
95	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.92649722
96	MYB_26560356_Chip-Seq_TH2_Human	0.91790307
97	RBPJ_21746931_ChIP-Seq_IB4_Human	0.91660174
98	FUS_26573619_Chip-Seq_HEK293_Human	0.91321350
99	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.90702874
100	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.90326493

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	3.63303537
2	MP0002102_abnormal_ear_morphology	3.34309737
3	MP0005671_abnormal_response_to	3.27943652
4	MP0006072_abnormal_retinal_apoptosis	3.12126392
5	MP0008877_abnormal_DNA_methylation	2.83485968
6	MP0002822_catalepsy	2.70297700
7	MP0000372_irregular_coat_pigmentation	2.65897047
8	MP0002837_dystrophic_cardiac_calcinosis	2.49230680
9	MP0005646_abnormal_pituitary_gland	2.36263965
10	MP0009697_abnormal_copulation	2.33293997
11	MP0001968_abnormal_touch/_nociception	2.31722588
12	MP0003786_premature_aging	2.26251529
13	MP0001835_abnormal_antigen_presentation	2.25730906
14	MP0002234_abnormal_pharynx_morphology	2.23693305
15	MP0003787_abnormal_imprinting	2.20775511
16	MP0001905_abnormal_dopamine_level	2.10947793
17	MP0001986_abnormal_taste_sensitivity	2.06470457
18	MP0001529_abnormal_vocalization	1.99899921
19	MP0008875_abnormal_xenobiotic_pharmacok	1.82605954
20	MP0003724_increased_susceptibility_to	1.82111137
21	MP0009379_abnormal_foot_pigmentation	1.81612260
22	MP0003195_calcinosis	1.79092995
23	MP0008995_early_reproductive_senescence	1.76193421
24	MP0008058_abnormal_DNA_repair	1.67671035
25	MP0002736_abnormal_nociception_after	1.65751708
26	MP0009764_decreased_sensitivity_to	1.64902107
27	MP0001873_stomach_inflammation	1.61217488
28	MP0005379_endocrine/exocrine_gland_phen	1.57005552
29	MP0005503_abnormal_tendon_morphology	1.56553619
30	MP0003718_maternal_effect	1.56421967
31	MP0005253_abnormal_eye_physiology	1.56374753
32	MP0003646_muscle_fatigue	1.54248782
33	MP0005171_absent_coat_pigmentation	1.51183881
34	MP0005645_abnormal_hypothalamus_physiol	1.48064383
35	MP0001984_abnormal_olfaction	1.47593044
36	MP0008872_abnormal_physiological_respon	1.46613741
37	MP0002735_abnormal_chemical_nociception	1.45322193
38	MP0002876_abnormal_thyroid_physiology	1.44909171
39	MP0006292_abnormal_olfactory_placode	1.42687105
40	MP0001919_abnormal_reproductive_system	1.41966273
41	MP0003186_abnormal_redox_activity	1.40170987
42	MP0002163_abnormal_gland_morphology	1.40052739
43	MP0004885_abnormal_endolymph	1.35927257
44	MP0002148_abnormal_hypersensitivity_rea	1.33050801
45	MP0000685_abnormal_immune_system	1.32357132
46	MP0008789_abnormal_olfactory_epithelium	1.30489466
47	MP0003878_abnormal_ear_physiology	1.29736401
48	MP0005377_hearing/vestibular/ear_phenot	1.29736401
49	MP0005410_abnormal_fertilization	1.28569833
50	MP0003121_genomic_imprinting	1.24811947
51	MP0003763_abnormal_thymus_physiology	1.23878508
52	MP0005551_abnormal_eye_electrophysiolog	1.22645507
53	MP0001764_abnormal_homeostasis	1.22192659
54	MP0006036_abnormal_mitochondrial_physio	1.21396263
55	MP0003866_abnormal_defecation	1.20088437
56	MP0002166_altered_tumor_susceptibility	1.16738399
57	MP0003283_abnormal_digestive_organ	1.14073993
58	MP0004142_abnormal_muscle_tone	1.12992985
59	MP0000427_abnormal_hair_cycle	1.11866906
60	MP0009785_altered_susceptibility_to	1.11533202
61	MP0002933_joint_inflammation	1.10676190
62	MP0006035_abnormal_mitochondrial_morpho	1.08799708
63	MP0002006_tumorigenesis	1.02991909
64	MP0003638_abnormal_response/metabolism_	1.02358831
65	MP0003252_abnormal_bile_duct	0.95561430
66	MP0005389_reproductive_system_phenotype	0.95112114
67	MP0004924_abnormal_behavior	0.93467857
68	MP0005386_behavior/neurological_phenoty	0.93467857
69	MP0001800_abnormal_humoral_immune	0.93350002
70	MP0001661_extended_life_span	0.92613258
71	MP0002282_abnormal_trachea_morphology	0.91998720
72	MP0002277_abnormal_respiratory_mucosa	0.91457273
73	MP0002723_abnormal_immune_serum	0.90466350
74	MP0010094_abnormal_chromosome_stability	0.90268693
75	MP0003011_delayed_dark_adaptation	0.89901385
76	MP0010386_abnormal_urinary_bladder	0.88416889
77	MP0005636_abnormal_mineral_homeostasis	0.88226366
78	MP0005000_abnormal_immune_tolerance	0.86953466
79	MP0004145_abnormal_muscle_electrophysio	0.86908484
80	MP0002272_abnormal_nervous_system	0.86810308
81	MP0003137_abnormal_impulse_conducting	0.83491769
82	MP0002693_abnormal_pancreas_physiology	0.83435487
83	MP0005167_abnormal_blood-brain_barrier	0.82430844
84	MP0003880_abnormal_central_pattern	0.78468013
85	MP0002452_abnormal_antigen_presenting	0.78061661
86	MP0009745_abnormal_behavioral_response	0.77394246
87	MP0005332_abnormal_amino_acid	0.77310539
88	MP0001485_abnormal_pinna_reflex	0.76943152
89	MP0004742_abnormal_vestibular_system	0.76523219
90	MP0001970_abnormal_pain_threshold	0.76464948
91	MP0002138_abnormal_hepatobiliary_system	0.76380645
92	MP0001188_hyperpigmentation	0.75809659
93	MP0001845_abnormal_inflammatory_respons	0.75208191
94	MP0000230_abnormal_systemic_arterial	0.74490053
95	MP0005394_taste/olfaction_phenotype	0.74130539
96	MP0005499_abnormal_olfactory_system	0.74130539
97	MP0001929_abnormal_gametogenesis	0.73990723
98	MP0001819_abnormal_immune_cell	0.73674398
99	MP0002420_abnormal_adaptive_immunity	0.73116355
100	MP0004043_abnormal_pH_regulation	0.72097578

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	5.80744376
2	Lipid accumulation in hepatocytes (HP:0006561)	5.22653054
3	Mitochondrial inheritance (HP:0001427)	4.71316728
4	Renal Fanconi syndrome (HP:0001994)	4.65099528
5	Congenital, generalized hypertrichosis (HP:0004540)	4.53109246
6	Increased intramyocellular lipid droplets (HP:0012240)	4.43907851
7	Increased CSF lactate (HP:0002490)	4.31590377
8	Acute necrotizing encephalopathy (HP:0006965)	4.28303744
9	Hepatocellular necrosis (HP:0001404)	4.23823004
10	Hepatic necrosis (HP:0002605)	4.23070988
11	3-Methylglutaconic aciduria (HP:0003535)	4.05770389
12	Abnormal mitochondria in muscle tissue (HP:0008316)	3.95230304
13	Exertional dyspnea (HP:0002875)	3.86713059
14	Acute encephalopathy (HP:0006846)	3.80820162
15	Progressive macrocephaly (HP:0004481)	3.65770063
16	Increased muscle lipid content (HP:0009058)	3.64119755
17	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.38716577
18	Abnormality of urine glucose concentration (HP:0011016)	3.35807058
19	Glycosuria (HP:0003076)	3.35807058
20	Hypothermia (HP:0002045)	3.22587227
21	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.14890222
22	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.14890222
23	Increased serum lactate (HP:0002151)	3.11814351
24	Cerebral edema (HP:0002181)	3.07497538
25	Generalized aminoaciduria (HP:0002909)	3.05553367
26	Hyperglycinemia (HP:0002154)	2.94571213
27	Lactic acidosis (HP:0003128)	2.92818044
28	Congenital stationary night blindness (HP:0007642)	2.84731691
29	IgG deficiency (HP:0004315)	2.82266852
30	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.80513266
31	Abnormality of renal resorption (HP:0011038)	2.75365550
32	Hyperphosphaturia (HP:0003109)	2.65544128
33	Delayed CNS myelination (HP:0002188)	2.65128156
34	Renal cortical cysts (HP:0000803)	2.65035050
35	Chronic sinusitis (HP:0011109)	2.63906232
36	Respiratory difficulties (HP:0002880)	2.61748527
37	Medial flaring of the eyebrow (HP:0010747)	2.59380444
38	Methylmalonic acidemia (HP:0002912)	2.56263945
39	Conjunctival telangiectasia (HP:0000524)	2.46119635
40	Decreased central vision (HP:0007663)	2.45129518
41	Respiratory failure (HP:0002878)	2.38087704
42	Severe combined immunodeficiency (HP:0004430)	2.35875264
43	Nephrogenic diabetes insipidus (HP:0009806)	2.34418827
44	Degeneration of anterior horn cells (HP:0002398)	2.34121960
45	Abnormality of the anterior horn cell (HP:0006802)	2.34121960
46	Stomach cancer (HP:0012126)	2.34045978
47	Woolly hair (HP:0002224)	2.32344461
48	Abnormality of serine family amino acid metabolism (HP:0010894)	2.31135898
49	Abnormality of glycine metabolism (HP:0010895)	2.31135898
50	Hyperglycinuria (HP:0003108)	2.27262141
51	Thyroiditis (HP:0100646)	2.25680813
52	Congenital primary aphakia (HP:0007707)	2.25078884
53	Type I transferrin isoform profile (HP:0003642)	2.24878387
54	Optic disc pallor (HP:0000543)	2.24216923
55	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.22502263
56	Parakeratosis (HP:0001036)	2.22454139
57	Gait imbalance (HP:0002141)	2.20618390
58	Pancreatic cysts (HP:0001737)	2.19830951
59	Pancytopenia (HP:0001876)	2.17218539
60	Lethargy (HP:0001254)	2.12692494
61	Recurrent bronchitis (HP:0002837)	2.08218900
62	Dicarboxylic aciduria (HP:0003215)	2.07806354
63	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.07806354
64	Exercise intolerance (HP:0003546)	2.07111449
65	Abnormality of the renal cortex (HP:0011035)	2.05559891
66	Abolished electroretinogram (ERG) (HP:0000550)	2.02728819
67	Colon cancer (HP:0003003)	1.99330107
68	Methylmalonic aciduria (HP:0012120)	1.98837221
69	Hypoproteinemia (HP:0003075)	1.98829357
70	Hypoglycemic seizures (HP:0002173)	1.98467975
71	Hypoplasia of the pons (HP:0012110)	1.94139574
72	Neoplasm of the adrenal cortex (HP:0100641)	1.93812098
73	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.93595740
74	Abnormality of B cell number (HP:0010975)	1.93383781
75	Abnormality of the pons (HP:0007361)	1.91356422
76	Inability to walk (HP:0002540)	1.89415689
77	Abnormal urine phosphate concentration (HP:0012599)	1.82391794
78	Renal tubular dysfunction (HP:0000124)	1.82188460
79	Ketosis (HP:0001946)	1.81375510
80	CNS demyelination (HP:0007305)	1.78164635
81	Spinal muscular atrophy (HP:0007269)	1.78083837
82	Abnormality of eosinophils (HP:0001879)	1.75585003
83	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.75102507
84	Metabolic acidosis (HP:0001942)	1.74487500
85	Nephronophthisis (HP:0000090)	1.73709933
86	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.73519187
87	Abnormality of vitamin B metabolism (HP:0004340)	1.71482931
88	B lymphocytopenia (HP:0010976)	1.69447568
89	Molar tooth sign on MRI (HP:0002419)	1.69220943
90	Abnormality of midbrain morphology (HP:0002418)	1.69220943
91	Leukodystrophy (HP:0002415)	1.68902882
92	Microretrognathia (HP:0000308)	1.68757923
93	Rectovaginal fistula (HP:0000143)	1.66987413
94	Rectal fistula (HP:0100590)	1.66987413
95	Hypomagnesemia (HP:0002917)	1.66501618
96	Abnormality of the prostate (HP:0008775)	1.66440117
97	Fibular aplasia (HP:0002990)	1.66044038
98	Alveolar cell carcinoma (HP:0006519)	1.65048306
99	Opisthotonus (HP:0002179)	1.63214193
100	Bronchitis (HP:0012387)	1.62476545

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	5.04938054
2	MAP4K2	4.11642858
3	TAOK3	3.26794152
4	TLK1	3.06792000
5	BMPR2	2.93260608
6	SRPK1	2.92881745
7	TXK	2.88160848
8	BCKDK	2.79023324
9	VRK2	2.62130379
10	STK16	2.32218803
11	MST4	2.19800183
12	LIMK1	2.11379359
13	NUAK1	1.99459975
14	TESK1	1.89921881
15	TIE1	1.86690779
16	GRK1	1.84760730
17	EPHA3	1.77193317
18	VRK1	1.76725934
19	CDC7	1.61358796
20	TESK2	1.48264259
21	ADRBK2	1.42582968
22	AKT3	1.41792290
23	CDK8	1.40381640
24	TRIM28	1.36402767
25	WNK4	1.34512452
26	TEC	1.31896696
27	MAP3K12	1.24092529
28	RIPK4	1.23246228
29	FRK	1.17246228
30	TNK2	1.13900325
31	LATS1	1.12940030
32	EPHA4	1.11751909
33	PLK4	1.11401112
34	KDR	1.09478365
35	PASK	1.09191886
36	DAPK1	1.09182716
37	MYLK	1.05227139
38	PHKG1	1.00963810
39	PHKG2	1.00963810
40	NME1	0.98040572
41	CSNK1G3	0.95807779
42	SCYL2	0.91299680
43	BUB1	0.86511636
44	CDK9	0.81461825
45	IKBKB	0.78236555
46	PIM2	0.76970725
47	ITK	0.76857724
48	CSNK1G1	0.74769268
49	PINK1	0.74137334
50	CSNK1A1L	0.73387495
51	INSRR	0.73233178
52	CASK	0.70969493
53	PLK3	0.70518679
54	CSNK1G2	0.70445130
55	GRK6	0.69171744
56	DYRK2	0.66083727
57	SYK	0.65272525
58	EIF2AK3	0.62405456
59	FES	0.62042675
60	CCNB1	0.61801559
61	CHEK2	0.60192496
62	OXSR1	0.59713827
63	BTK	0.56646840
64	RPS6KA5	0.55805665
65	LCK	0.55104966
66	MAP3K4	0.54129734
67	KIT	0.53682014
68	NEK1	0.51544320
69	EIF2AK2	0.49205607
70	LYN	0.48951965
71	CSF1R	0.47238259
72	MAP2K7	0.47147118
73	IKBKE	0.46760729
74	TSSK6	0.45195213
75	BMPR1B	0.44830843
76	ATR	0.43304873
77	PLK2	0.43036363
78	BRD4	0.42525409
79	PRKCQ	0.42316534
80	CDK3	0.40444809
81	PLK1	0.40226938
82	AURKB	0.38893410
83	IGF1R	0.38704583
84	PRKCE	0.36285427
85	MAP4K1	0.34792358
86	ADRBK1	0.33880545
87	FLT3	0.33363822
88	MAPKAPK5	0.33141669
89	PKN1	0.33058493
90	CSNK2A1	0.32169983
91	MAPK13	0.31413563
92	BCR	0.30106032
93	ABL1	0.29715635
94	DAPK3	0.29452164
95	PRKCA	0.29202372
96	TBK1	0.28285609
97	TAF1	0.26984672
98	MAP3K5	0.26971260
99	CHUK	0.26265594
100	EGFR	0.24467788

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.33007437
2	Proteasome_Homo sapiens_hsa03050	4.15627404
3	Parkinsons disease_Homo sapiens_hsa05012	3.56335522
4	Homologous recombination_Homo sapiens_hsa03440	2.73896778
5	Protein export_Homo sapiens_hsa03060	2.59001486
6	Ribosome_Homo sapiens_hsa03010	2.56596246
7	RNA polymerase_Homo sapiens_hsa03020	2.35662146
8	Alzheimers disease_Homo sapiens_hsa05010	2.25560630
9	Huntingtons disease_Homo sapiens_hsa05016	2.24061722
10	Mismatch repair_Homo sapiens_hsa03430	2.20251204
11	Non-homologous end-joining_Homo sapiens_hsa03450	2.15523518
12	Base excision repair_Homo sapiens_hsa03410	2.15434506
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.06898361
14	DNA replication_Homo sapiens_hsa03030	1.98645099
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.94621093
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.91041610
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.73480499
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.68630330
19	Asthma_Homo sapiens_hsa05310	1.66027905
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.60035648
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.55485366
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.55213917
23	Propanoate metabolism_Homo sapiens_hsa00640	1.47046379
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.46234316
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.42694985
26	RNA degradation_Homo sapiens_hsa03018	1.41814765
27	Sulfur metabolism_Homo sapiens_hsa00920	1.40430772
28	One carbon pool by folate_Homo sapiens_hsa00670	1.37695646
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.35668231
30	Collecting duct acid secretion_Homo sapiens_hsa04966	1.34271482
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.32410732
32	Spliceosome_Homo sapiens_hsa03040	1.30488907
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.29935796
34	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.28855598
35	Basal transcription factors_Homo sapiens_hsa03022	1.20107621
36	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.19450590
37	Peroxisome_Homo sapiens_hsa04146	1.18793760
38	Butanoate metabolism_Homo sapiens_hsa00650	1.16459944
39	Purine metabolism_Homo sapiens_hsa00230	1.12596657
40	Phototransduction_Homo sapiens_hsa04744	1.10737782
41	Allograft rejection_Homo sapiens_hsa05330	1.03801297
42	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.03665879
43	Fanconi anemia pathway_Homo sapiens_hsa03460	1.03145516
44	Graft-versus-host disease_Homo sapiens_hsa05332	0.97986988
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.97716639
46	Type I diabetes mellitus_Homo sapiens_hsa04940	0.96062081
47	Rheumatoid arthritis_Homo sapiens_hsa05323	0.93404299
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.93093134
49	Fatty acid elongation_Homo sapiens_hsa00062	0.90963443
50	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.87339045
51	Caffeine metabolism_Homo sapiens_hsa00232	0.85440970
52	Selenocompound metabolism_Homo sapiens_hsa00450	0.84926828
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.79691610
54	Metabolic pathways_Homo sapiens_hsa01100	0.79300367
55	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.78664868
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.78211206
57	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.70532891
58	Antigen processing and presentation_Homo sapiens_hsa04612	0.70389445
59	Regulation of autophagy_Homo sapiens_hsa04140	0.66785393
60	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.66634381
61	Taste transduction_Homo sapiens_hsa04742	0.66471400
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65809058
63	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.63740341
64	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.60666944
65	Nicotine addiction_Homo sapiens_hsa05033	0.58060219
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.57756563
67	Sulfur relay system_Homo sapiens_hsa04122	0.57364977
68	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.56303333
69	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.55763104
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.53866062
71	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.53396696
72	Morphine addiction_Homo sapiens_hsa05032	0.53365769
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51952793
74	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.50800999
75	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.49086340
76	Folate biosynthesis_Homo sapiens_hsa00790	0.48718239
77	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.46602085
78	Retinol metabolism_Homo sapiens_hsa00830	0.46417316
79	Mineral absorption_Homo sapiens_hsa04978	0.45365598
80	RNA transport_Homo sapiens_hsa03013	0.43576314
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.42956878
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42785898
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.41625178
84	Vibrio cholerae infection_Homo sapiens_hsa05110	0.41508133
85	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.38395348
86	Glutathione metabolism_Homo sapiens_hsa00480	0.36188914
87	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36050898
88	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.35911108
89	Steroid biosynthesis_Homo sapiens_hsa00100	0.35746390
90	Fat digestion and absorption_Homo sapiens_hsa04975	0.34538107
91	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.33530133
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.33529293
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.32150486
94	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.30081662
95	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.29961341
96	Salivary secretion_Homo sapiens_hsa04970	0.28045992
97	Olfactory transduction_Homo sapiens_hsa04740	0.27273613
98	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.26993447
99	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.26783957
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.22914883

ATP5A1P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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