ATP5A1P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1substrate-independent telencephalic tangential migration (GO:0021826)8.17562827
2substrate-independent telencephalic tangential interneuron migration (GO:0021843)8.17562827
3nonmotile primary cilium assembly (GO:0035058)7.72576156
4cornea development in camera-type eye (GO:0061303)7.17448553
5maturation of SSU-rRNA (GO:0030490)5.94347989
6ribosomal small subunit biogenesis (GO:0042274)5.55111052
7regulation of timing of cell differentiation (GO:0048505)5.35998541
8left/right axis specification (GO:0070986)5.28364926
9somite development (GO:0061053)5.21593495
10behavioral response to nicotine (GO:0035095)5.14103793
11response to gravity (GO:0009629)4.91029206
12regulation of development, heterochronic (GO:0040034)4.89274508
13viral transcription (GO:0019083)4.82712044
14chaperone-mediated protein transport (GO:0072321)4.58271175
15translational termination (GO:0006415)4.54639625
16astrocyte differentiation (GO:0048708)4.20534706
17translational elongation (GO:0006414)4.12747575
18segment specification (GO:0007379)4.04823732
19dorsal/ventral axis specification (GO:0009950)4.03193192
20positive regulation of cell fate commitment (GO:0010455)4.02134717
21ribosomal small subunit assembly (GO:0000028)3.97585408
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.87180365
23ATP synthesis coupled proton transport (GO:0015986)3.85248104
24energy coupled proton transport, down electrochemical gradient (GO:0015985)3.85248104
25cotranslational protein targeting to membrane (GO:0006613)3.80627054
26cell proliferation in forebrain (GO:0021846)3.78934208
27protein targeting to ER (GO:0045047)3.77049203
28glandular epithelial cell differentiation (GO:0002067)3.73696986
29protein localization to endoplasmic reticulum (GO:0070972)3.67904807
30establishment of protein localization to endoplasmic reticulum (GO:0072599)3.60329695
31positive regulation of neuroblast proliferation (GO:0002052)3.53266479
32hindbrain development (GO:0030902)3.48857743
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.48806273
34lens development in camera-type eye (GO:0002088)3.43710400
35cellular protein complex disassembly (GO:0043624)3.38615870
36viral life cycle (GO:0019058)3.35875076
37response to folic acid (GO:0051593)3.35382744
38dorsal/ventral pattern formation (GO:0009953)3.31457874
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.30365635
40ribosomal large subunit biogenesis (GO:0042273)3.27260694
41photoreceptor cell development (GO:0042461)3.22816474
42aldehyde catabolic process (GO:0046185)3.22575861
43negative regulation of muscle hypertrophy (GO:0014741)3.21895034
44nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.21812076
45regulation of transcription involved in cell fate commitment (GO:0060850)3.21362268
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19086247
47mitochondrial respiratory chain complex I assembly (GO:0032981)3.18710125
48NADH dehydrogenase complex assembly (GO:0010257)3.18710125
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.18710125
50pituitary gland development (GO:0021983)3.16984616
51regulation of gene expression by genetic imprinting (GO:0006349)3.16635646
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16295433
53limb development (GO:0060173)3.13411167
54appendage development (GO:0048736)3.13411167
55metallo-sulfur cluster assembly (GO:0031163)3.12909135
56iron-sulfur cluster assembly (GO:0016226)3.12909135
57smoothened signaling pathway (GO:0007224)3.07641360
58positive regulation of neurological system process (GO:0031646)3.05373036
59DNA deamination (GO:0045006)3.04943203
60negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.01282899
61genetic imprinting (GO:0071514)3.00844153
62translational initiation (GO:0006413)3.00743653
63mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.98354300
64eye photoreceptor cell development (GO:0042462)2.96724553
65skeletal muscle tissue regeneration (GO:0043403)2.96237546
66indolalkylamine metabolic process (GO:0006586)2.95551719
67protein complex disassembly (GO:0043241)2.95457617
68protein complex biogenesis (GO:0070271)2.95286113
69dentate gyrus development (GO:0021542)2.95245731
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.94334079
71metanephric tubule development (GO:0072170)2.91799379
72metanephric nephron tubule development (GO:0072234)2.91799379
73positive regulation of mitochondrial fission (GO:0090141)2.88740619
74protein peptidyl-prolyl isomerization (GO:0000413)2.87350240
75macromolecular complex disassembly (GO:0032984)2.85723212
76cellular component biogenesis (GO:0044085)2.85685165
77ribonucleoprotein complex biogenesis (GO:0022613)2.85197680
78platelet dense granule organization (GO:0060155)2.82240213
79cilium morphogenesis (GO:0060271)2.82195104
80glandular epithelial cell development (GO:0002068)2.80207893
81pyrimidine nucleobase catabolic process (GO:0006208)2.76632978
82negative regulation of telomere maintenance (GO:0032205)2.72986877
83translation (GO:0006412)2.72689581
84regulation of glucokinase activity (GO:0033131)2.72154202
85regulation of hexokinase activity (GO:1903299)2.72154202
86regulation of telomerase activity (GO:0051972)2.69632513
87positive regulation of defense response to virus by host (GO:0002230)2.68964364
88kidney morphogenesis (GO:0060993)2.68635917
89epithelial cilium movement (GO:0003351)2.66189848
90kynurenine metabolic process (GO:0070189)2.65066286
91neuron fate commitment (GO:0048663)2.64036826
92protein targeting to membrane (GO:0006612)2.62551665
93regulation of neuroblast proliferation (GO:1902692)2.60954811
94forebrain neuron differentiation (GO:0021879)2.59928007
95protein neddylation (GO:0045116)2.59390506
96head development (GO:0060322)2.59389309
97spinal cord association neuron differentiation (GO:0021527)2.58651264
98regulation of cilium movement (GO:0003352)2.57630075
99negative regulation of oligodendrocyte differentiation (GO:0048715)2.57216401
100synaptic transmission, cholinergic (GO:0007271)2.56814246

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.41833162
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.84772387
3CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.59423212
4VDR_22108803_ChIP-Seq_LS180_Human3.51887744
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.39242439
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.68762611
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.66159123
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59695600
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.51341067
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41883724
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.39578126
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.36979582
13POU5F1_16153702_ChIP-ChIP_HESCs_Human2.22476636
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06928162
15TAF15_26573619_Chip-Seq_HEK293_Human2.05861790
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.02446806
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.01014441
18ZNF274_21170338_ChIP-Seq_K562_Hela1.91414937
19IGF1R_20145208_ChIP-Seq_DFB_Human1.91194441
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.85427307
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.81174270
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75317723
23RNF2_27304074_Chip-Seq_NSC_Mouse1.73157874
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68728436
25ELK1_19687146_ChIP-ChIP_HELA_Human1.68718362
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66260734
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62363657
28GBX2_23144817_ChIP-Seq_PC3_Human1.61662731
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61072564
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58053546
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57755410
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56103722
33IRF1_19129219_ChIP-ChIP_H3396_Human1.52922650
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47016825
35MYC_18940864_ChIP-ChIP_HL60_Human1.45793036
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.41585437
37RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.41504757
38FUS_26573619_Chip-Seq_HEK293_Human1.39834735
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.39658844
40TTF2_22483619_ChIP-Seq_HELA_Human1.38543246
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.38337631
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37808964
43P300_19829295_ChIP-Seq_ESCs_Human1.37755129
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36052308
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35961808
46TP53_22573176_ChIP-Seq_HFKS_Human1.35368120
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.34060007
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33995961
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31474877
50TDRD3_21172665_ChIP-Seq_MCF-7_Human1.31203032
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30680247
52REST_21632747_ChIP-Seq_MESCs_Mouse1.29252974
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27986345
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25918046
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23980769
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23980769
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21463681
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21347636
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20655176
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20655176
61TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.20242035
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18080628
63VDR_23849224_ChIP-Seq_CD4+_Human1.15508717
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.13220511
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12919857
66SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09109883
67ERA_21632823_ChIP-Seq_H3396_Human1.08983512
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.08895170
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08109070
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.07607049
71AR_20517297_ChIP-Seq_VCAP_Human1.07308249
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04949534
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04556135
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04512788
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03943470
76HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.03651143
77FOXP3_21729870_ChIP-Seq_TREG_Human1.02162574
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01530936
79CBP_20019798_ChIP-Seq_JUKART_Human1.01530936
80NCOR_22424771_ChIP-Seq_293T_Human1.01506868
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01386373
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00731779
83CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00569177
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00527882
85CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98609800
86NANOG_16153702_ChIP-ChIP_HESCs_Human0.98229274
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97955663
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96737858
89MYC_18555785_ChIP-Seq_MESCs_Mouse0.96379655
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.95282357
91PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94973666
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93542939
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92718201
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92502151
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92484692
96FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90615841
97FOXA1_25329375_ChIP-Seq_VCAP_Human0.90615841
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.90472205
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.88775672
100EWS_26573619_Chip-Seq_HEK293_Human0.85055689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode8.07266307
2MP0003787_abnormal_imprinting5.05397779
3MP0005257_abnormal_intraocular_pressure5.00487136
4MP0008789_abnormal_olfactory_epithelium4.60348223
5MP0005499_abnormal_olfactory_system3.77383048
6MP0005394_taste/olfaction_phenotype3.77383048
7MP0008877_abnormal_DNA_methylation3.63932173
8MP0002638_abnormal_pupillary_reflex3.55892525
9MP0009379_abnormal_foot_pigmentation3.42999474
10MP0005083_abnormal_biliary_tract2.88823531
11MP0002938_white_spotting2.31368967
12MP0002163_abnormal_gland_morphology2.25519721
13MP0003121_genomic_imprinting2.14804093
14MP0003123_paternal_imprinting1.93413248
15MP0010030_abnormal_orbit_morphology1.90321794
16MP0005084_abnormal_gallbladder_morpholo1.83686283
17MP0000049_abnormal_middle_ear1.80834576
18MP0006276_abnormal_autonomic_nervous1.79322955
19MP0002160_abnormal_reproductive_system1.75771342
20MP0000613_abnormal_salivary_gland1.71796733
21MP0002102_abnormal_ear_morphology1.58644878
22MP0001293_anophthalmia1.55187316
23MP0000778_abnormal_nervous_system1.48131782
24MP0004142_abnormal_muscle_tone1.42860611
25MP0005646_abnormal_pituitary_gland1.40628092
26MP0003283_abnormal_digestive_organ1.37509978
27MP0004145_abnormal_muscle_electrophysio1.37104654
28MP0003937_abnormal_limbs/digits/tail_de1.33503848
29MP0003880_abnormal_central_pattern1.32063907
30MP0006072_abnormal_retinal_apoptosis1.26853312
31MP0009046_muscle_twitch1.26375295
32MP0005379_endocrine/exocrine_gland_phen1.09156840
33MP0004133_heterotaxia1.07485191
34MP0005551_abnormal_eye_electrophysiolog1.04679339
35MP0000647_abnormal_sebaceous_gland1.02113903
36MP0002177_abnormal_outer_ear1.01064502
37MP0001270_distended_abdomen1.01026940
38MP0000631_abnormal_neuroendocrine_gland1.00085501
39MP0002822_catalepsy0.99020967
40MP0005085_abnormal_gallbladder_physiolo0.98123529
41MP0001905_abnormal_dopamine_level0.95367208
42MP0005389_reproductive_system_phenotype0.95226583
43MP0003122_maternal_imprinting0.95054063
44MP0005195_abnormal_posterior_eye0.94966672
45MP0002233_abnormal_nose_morphology0.94916581
46MP0009053_abnormal_anal_canal0.93040317
47MP0000955_abnormal_spinal_cord0.91633905
48MP0001968_abnormal_touch/_nociception0.90395826
49MP0002272_abnormal_nervous_system0.89815138
50MP0001324_abnormal_eye_pigmentation0.89801548
51MP0002095_abnormal_skin_pigmentation0.87915810
52MP0004134_abnormal_chest_morphology0.87548388
53MP0002752_abnormal_somatic_nervous0.87186959
54MP0002184_abnormal_innervation0.87054814
55MP0002734_abnormal_mechanical_nocicepti0.85888906
56MP0001529_abnormal_vocalization0.85617116
57MP0001286_abnormal_eye_development0.85012627
58MP0003938_abnormal_ear_development0.84977926
59MP0002736_abnormal_nociception_after0.83504116
60MP0002837_dystrophic_cardiac_calcinosis0.83082637
61MP0009745_abnormal_behavioral_response0.80632335
62MP0002557_abnormal_social/conspecific_i0.79806536
63MP0000428_abnormal_craniofacial_morphol0.79244767
64MP0002876_abnormal_thyroid_physiology0.78704807
65MP0003119_abnormal_digestive_system0.78404085
66MP0003755_abnormal_palate_morphology0.77981140
67MP0002653_abnormal_ependyma_morphology0.76038651
68MP0002092_abnormal_eye_morphology0.71852650
69MP0002111_abnormal_tail_morphology0.71145611
70MP0002932_abnormal_joint_morphology0.70762567
71MP0005391_vision/eye_phenotype0.67339513
72MP0005423_abnormal_somatic_nervous0.67047226
73MP0002572_abnormal_emotion/affect_behav0.66932483
74MP0002234_abnormal_pharynx_morphology0.66646849
75MP0005220_abnormal_exocrine_pancreas0.66368458
76MP0003646_muscle_fatigue0.66176608
77MP0002116_abnormal_craniofacial_bone0.66091236
78MP0005645_abnormal_hypothalamus_physiol0.65158604
79MP0010386_abnormal_urinary_bladder0.63551334
80MP0001299_abnormal_eye_distance/0.61438534
81MP0002089_abnormal_postnatal_growth/wei0.60459988
82MP0001919_abnormal_reproductive_system0.59809667
83MP0001986_abnormal_taste_sensitivity0.59401225
84MP0002928_abnormal_bile_duct0.59133404
85MP0003011_delayed_dark_adaptation0.57496060
86MP0003635_abnormal_synaptic_transmissio0.56554230
87MP0001944_abnormal_pancreas_morphology0.55779800
88MP0000026_abnormal_inner_ear0.54739109
89MP0002064_seizures0.54357047
90MP0000538_abnormal_urinary_bladder0.54069577
91MP0004147_increased_porphyrin_level0.53558251
92MP0004859_abnormal_synaptic_plasticity0.53278487
93MP0002210_abnormal_sex_determination0.53183318
94MP0003861_abnormal_nervous_system0.53006988
95MP0001502_abnormal_circadian_rhythm0.51605069
96MP0003942_abnormal_urinary_system0.51413289
97MP0005410_abnormal_fertilization0.50027520
98MP0001970_abnormal_pain_threshold0.49203812
99MP0002735_abnormal_chemical_nociception0.48990325
100MP0002882_abnormal_neuron_morphology0.48353515

Predicted human phenotypes

RankGene SetZ-score
1Molar tooth sign on MRI (HP:0002419)5.76484783
2Abnormality of midbrain morphology (HP:0002418)5.76484783
3Hypoplasia of the fovea (HP:0007750)5.40740090
4Aplasia/Hypoplasia of the fovea (HP:0008060)5.40740090
5Aplasia/Hypoplasia of the sacrum (HP:0008517)4.77563103
6Abnormality of the fovea (HP:0000493)4.51686166
7Pancreatic fibrosis (HP:0100732)4.17664979
8Absent rod-and cone-mediated responses on ERG (HP:0007688)4.05560167
9Anencephaly (HP:0002323)3.76065529
10Reticulocytopenia (HP:0001896)3.74247011
11Pancreatic cysts (HP:0001737)3.69017610
12Pendular nystagmus (HP:0012043)3.64890011
13True hermaphroditism (HP:0010459)3.46781281
14Aplasia/Hypoplasia of the macula (HP:0008059)3.26442694
15Optic nerve coloboma (HP:0000588)3.24245164
16Aplasia/Hypoplasia affecting the retina (HP:0008061)3.06979328
17Increased corneal curvature (HP:0100692)2.91834323
18Keratoconus (HP:0000563)2.91834323
19Acute necrotizing encephalopathy (HP:0006965)2.86377609
20Abnormal rod and cone electroretinograms (HP:0008323)2.83159476
21Optic nerve hypoplasia (HP:0000609)2.79748104
22Decreased central vision (HP:0007663)2.79341325
23Mask-like facies (HP:0000298)2.79064075
24Nephronophthisis (HP:0000090)2.68468983
25Absent phalangeal crease (HP:0006109)2.62635273
26Cystic liver disease (HP:0006706)2.57507625
27Fused cervical vertebrae (HP:0002949)2.57157890
28Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.56964633
29Mitochondrial inheritance (HP:0001427)2.56016241
30Postaxial foot polydactyly (HP:0001830)2.54491168
31Abolished electroretinogram (ERG) (HP:0000550)2.50312905
32Abnormal mitochondria in muscle tissue (HP:0008316)2.50236704
33Abnormality of the phalanges of the 5th finger (HP:0004213)2.46045716
34Abnormality of cells of the erythroid lineage (HP:0012130)2.44164559
35Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.43314128
36Progressive macrocephaly (HP:0004481)2.40640213
37Oligodactyly (hands) (HP:0001180)2.40292524
38Palpebral edema (HP:0100540)2.40016270
39Short middle phalanx of the 5th finger (HP:0004220)2.39903848
40Neoplasm of the adrenal cortex (HP:0100641)2.37270612
41Difficulty running (HP:0009046)2.33458656
42Adrenal hypoplasia (HP:0000835)2.32833992
43Renal dysplasia (HP:0000110)2.31615634
44Type II lissencephaly (HP:0007260)2.29197543
45Symphalangism affecting the phalanges of the hand (HP:0009773)2.26763115
46Abnormality of the 4th metacarpal (HP:0010012)2.25939485
47Aplasia/Hypoplasia of the lens (HP:0008063)2.24775391
48Neonatal hypoglycemia (HP:0001998)2.23985562
49Medial flaring of the eyebrow (HP:0010747)2.22949036
50Abnormal pancreas size (HP:0012094)2.22754493
51Increased CSF lactate (HP:0002490)2.22161726
52Acute encephalopathy (HP:0006846)2.18733717
53Abnormality of the renal medulla (HP:0100957)2.18683071
54Sclerocornea (HP:0000647)2.15745795
55Abnormal number of erythroid precursors (HP:0012131)2.15088828
56Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.14375350
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.13021489
58Abnormal finger flexion creases (HP:0006143)2.09457659
59Esophageal atresia (HP:0002032)2.07415007
60Congenital glaucoma (HP:0001087)2.07259761
61Diastasis recti (HP:0001540)2.05907093
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05291179
63Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.05185721
64Hepatic necrosis (HP:0002605)2.05177818
65Hip dysplasia (HP:0001385)2.01929939
66Macrocytic anemia (HP:0001972)2.01783339
67Hepatocellular necrosis (HP:0001404)1.99076015
68Attenuation of retinal blood vessels (HP:0007843)1.98661008
69Myokymia (HP:0002411)1.95985997
70Congenital hepatic fibrosis (HP:0002612)1.95971787
71Preaxial hand polydactyly (HP:0001177)1.92125185
72Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.91899157
73Decreased circulating renin level (HP:0003351)1.91111193
74Cerebral edema (HP:0002181)1.90301744
75Colon cancer (HP:0003003)1.88364000
76Oculomotor apraxia (HP:0000657)1.87577381
77Oligodactyly (HP:0012165)1.87408447
78Status epilepticus (HP:0002133)1.87108599
79Abnormality of the middle phalanges of the toes (HP:0010183)1.86167181
80Limb dystonia (HP:0002451)1.85129319
81Absent thumb (HP:0009777)1.83695876
82Gait imbalance (HP:0002141)1.83610944
83Abnormal drinking behavior (HP:0030082)1.83176557
84Polydipsia (HP:0001959)1.83176557
85Narrow forehead (HP:0000341)1.82046973
86Anophthalmia (HP:0000528)1.78629793
87Dandy-Walker malformation (HP:0001305)1.76204660
88Abnormality of the distal phalanges of the toes (HP:0010182)1.74335539
89Pallor (HP:0000980)1.72946702
90Fibular hypoplasia (HP:0003038)1.71795159
91Congenital primary aphakia (HP:0007707)1.69967681
92Iris coloboma (HP:0000612)1.69661884
93Increased intramyocellular lipid droplets (HP:0012240)1.69563189
94Forearm undergrowth (HP:0009821)1.66682913
95Furrowed tongue (HP:0000221)1.66671570
96Abnormal hemoglobin (HP:0011902)1.66620849
97Holoprosencephaly (HP:0001360)1.65261331
98Abnormality of cochlea (HP:0000375)1.63239071
99Hip contracture (HP:0003273)1.62852483
100Renal Fanconi syndrome (HP:0001994)1.61227540

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.60435291
2MAPK133.39034937
3EPHB22.98489900
4PTK2B2.75264339
5FRK2.46257351
6HIPK22.25582251
7TLK12.24874328
8CDK192.15820264
9TRIM282.14652809
10ZAK2.08859336
11CSNK1G32.06931628
12LIMK11.99142279
13CSNK1G21.98821995
14BCR1.97965458
15PHKG11.89340998
16PHKG21.89340998
17MAP4K21.88914698
18CSNK1G11.88370225
19GRK11.87562770
20VRK21.79785551
21NME21.76165894
22MARK21.74083210
23STK161.64999319
24CCNB11.59147927
25TIE11.52325072
26CSNK1A1L1.49551536
27MUSK1.46949119
28WNK41.45116969
29WNK31.44493401
30MAPK71.37410736
31SRPK11.34838242
32MAP3K41.32660101
33PINK11.32658560
34ADRBK21.30427863
35PRKCI1.28540408
36STK111.17631811
37NUAK11.16718273
38TESK11.14549442
39PIM21.12633385
40MARK11.12071360
41MAP2K71.10198468
42MAPKAPK31.07777382
43OBSCN1.03973331
44OXSR11.03170583
45WNK11.02418311
46AURKA1.00485624
47DYRK20.99748090
48CHEK20.86432286
49TYRO30.83565043
50MINK10.83482676
51INSRR0.82551080
52PRKCG0.80828197
53TAOK30.78343397
54LRRK20.78256857
55PAK30.78032272
56RPS6KA20.77400109
57RPS6KA60.76347911
58ARAF0.76263969
59MARK30.73249137
60PAK60.72857346
61RPS6KC10.71361146
62RPS6KL10.71361146
63DYRK30.68145693
64PLK20.65077956
65CASK0.64806319
66CSNK1A10.62289425
67IRAK10.61328521
68CDC70.60734651
69PIK3CA0.59963570
70TAOK10.58408456
71VRK10.57846342
72BMPR1B0.56772974
73EPHA20.55967002
74PRKACA0.54056343
75DYRK1B0.53878388
76KSR10.52959121
77RPS6KA50.51010543
78DAPK30.50224384
79CAMK2D0.49614162
80CSNK1D0.49026601
81ROCK10.47235154
82IRAK20.46699943
83GSK3A0.46682003
84GRK70.46676099
85STK30.46169280
86EPHA40.44391681
87NTRK20.43926482
88CSNK2A20.43658109
89CSNK2A10.43210552
90LMTK20.42608670
91CAMK2G0.42430992
92CSNK1E0.40541081
93STK390.40536759
94AURKB0.40080214
95CAMK2A0.39927951
96WEE10.39093084
97TTK0.38086416
98CAMK10.37040568
99ABL20.34938325
100RPS6KB10.33388072

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.13078928
2Oxidative phosphorylation_Homo sapiens_hsa001903.58171598
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.15580258
4Parkinsons disease_Homo sapiens_hsa050123.09524211
5Cardiac muscle contraction_Homo sapiens_hsa042602.51774657
6Huntingtons disease_Homo sapiens_hsa050162.31936803
7Alzheimers disease_Homo sapiens_hsa050102.26685725
8One carbon pool by folate_Homo sapiens_hsa006702.21005495
9RNA degradation_Homo sapiens_hsa030182.19691057
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90062134
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.72669295
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69069353
13Proteasome_Homo sapiens_hsa030501.68397768
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59434043
15Hedgehog signaling pathway_Homo sapiens_hsa043401.59083179
16Tryptophan metabolism_Homo sapiens_hsa003801.55263428
17Protein export_Homo sapiens_hsa030601.51372993
18Nicotine addiction_Homo sapiens_hsa050331.47504831
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45915060
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43545960
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41907714
22Basal cell carcinoma_Homo sapiens_hsa052171.40854203
23Nitrogen metabolism_Homo sapiens_hsa009101.39700342
24RNA polymerase_Homo sapiens_hsa030201.38874542
25Phototransduction_Homo sapiens_hsa047441.37559682
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.35470039
27Mismatch repair_Homo sapiens_hsa034301.33905495
28Insulin secretion_Homo sapiens_hsa049111.33744723
29Peroxisome_Homo sapiens_hsa041461.27397460
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27000254
31Fanconi anemia pathway_Homo sapiens_hsa034601.22304000
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18267241
33Sulfur relay system_Homo sapiens_hsa041221.10690668
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04922536
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04675845
36Chemical carcinogenesis_Homo sapiens_hsa052041.04311717
37Fatty acid elongation_Homo sapiens_hsa000621.03311906
38Homologous recombination_Homo sapiens_hsa034401.01676944
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99347189
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97390319
41Steroid biosynthesis_Homo sapiens_hsa001000.96507643
42Tight junction_Homo sapiens_hsa045300.95050978
43Asthma_Homo sapiens_hsa053100.90686998
44Spliceosome_Homo sapiens_hsa030400.90326654
45Butanoate metabolism_Homo sapiens_hsa006500.89306063
46RNA transport_Homo sapiens_hsa030130.88944982
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88177507
48Gastric acid secretion_Homo sapiens_hsa049710.85392778
49Pyruvate metabolism_Homo sapiens_hsa006200.83325954
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.79861575
51Phenylalanine metabolism_Homo sapiens_hsa003600.79648960
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78990788
53Morphine addiction_Homo sapiens_hsa050320.78747736
54Axon guidance_Homo sapiens_hsa043600.78327542
55Nucleotide excision repair_Homo sapiens_hsa034200.76493752
56Basal transcription factors_Homo sapiens_hsa030220.75378901
57Pyrimidine metabolism_Homo sapiens_hsa002400.75375286
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75302844
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74239353
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74096068
61Salivary secretion_Homo sapiens_hsa049700.73245348
62Mineral absorption_Homo sapiens_hsa049780.73180348
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73075640
64Olfactory transduction_Homo sapiens_hsa047400.72249542
65Regulation of autophagy_Homo sapiens_hsa041400.70783140
66Retinol metabolism_Homo sapiens_hsa008300.70397305
67Carbon metabolism_Homo sapiens_hsa012000.70274812
68beta-Alanine metabolism_Homo sapiens_hsa004100.68148445
69Linoleic acid metabolism_Homo sapiens_hsa005910.67493916
70Serotonergic synapse_Homo sapiens_hsa047260.67031357
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66499117
72Systemic lupus erythematosus_Homo sapiens_hsa053220.65952202
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63978412
74Base excision repair_Homo sapiens_hsa034100.61853809
75Metabolic pathways_Homo sapiens_hsa011000.61731455
76Fat digestion and absorption_Homo sapiens_hsa049750.61441236
77Tyrosine metabolism_Homo sapiens_hsa003500.59895180
78DNA replication_Homo sapiens_hsa030300.59061007
79Wnt signaling pathway_Homo sapiens_hsa043100.57292497
80Circadian entrainment_Homo sapiens_hsa047130.55527342
81Hippo signaling pathway_Homo sapiens_hsa043900.55386106
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54220190
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53452877
84Dopaminergic synapse_Homo sapiens_hsa047280.53351501
85GABAergic synapse_Homo sapiens_hsa047270.52630939
86Propanoate metabolism_Homo sapiens_hsa006400.52441046
87Purine metabolism_Homo sapiens_hsa002300.51740159
88Bile secretion_Homo sapiens_hsa049760.49872889
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48496302
90Fatty acid degradation_Homo sapiens_hsa000710.48105898
91Taste transduction_Homo sapiens_hsa047420.44518539
92Alcoholism_Homo sapiens_hsa050340.44153482
93Synaptic vesicle cycle_Homo sapiens_hsa047210.43878268
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43045898
95Type I diabetes mellitus_Homo sapiens_hsa049400.41892910
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.40451600
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40268041
98Oxytocin signaling pathway_Homo sapiens_hsa049210.37289981
99Calcium signaling pathway_Homo sapiens_hsa040200.36901087
100Ovarian steroidogenesis_Homo sapiens_hsa049130.36811130

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