ATP5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)6.32415441
2establishment of integrated proviral latency (GO:0075713)4.72386192
3NADH metabolic process (GO:0006734)4.62917599
4regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.44046345
5oxidative phosphorylation (GO:0006119)4.39325136
6DNA unwinding involved in DNA replication (GO:0006268)4.35822420
7regulation of cofactor metabolic process (GO:0051193)4.29288390
8regulation of coenzyme metabolic process (GO:0051196)4.29288390
9regulation of translational fidelity (GO:0006450)4.07653039
10lysine catabolic process (GO:0006554)4.06675475
11lysine metabolic process (GO:0006553)4.06675475
12regulation of acyl-CoA biosynthetic process (GO:0050812)4.05627190
13establishment of viral latency (GO:0019043)4.02347623
14regulation of translational termination (GO:0006449)4.01486738
15proteasome assembly (GO:0043248)3.92582255
16tricarboxylic acid metabolic process (GO:0072350)3.87252240
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.85336233
18sarcomere organization (GO:0045214)3.84476949
19L-serine metabolic process (GO:0006563)3.82500680
20cardiac myofibril assembly (GO:0055003)3.78854896
21folic acid-containing compound biosynthetic process (GO:0009396)3.74283679
22cullin deneddylation (GO:0010388)3.72899627
23regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.70465433
24* mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.62928124
25anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.62450356
26positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.60617665
27IMP biosynthetic process (GO:0006188)3.59169911
28cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.57760103
29negative regulation of ligase activity (GO:0051352)3.53620814
30negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.53620814
31oxaloacetate metabolic process (GO:0006107)3.50270566
32protein deneddylation (GO:0000338)3.49318270
33negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.48063344
34regulation of cellular amino acid metabolic process (GO:0006521)3.46570997
35negative regulation of potassium ion transmembrane transport (GO:1901380)3.41722072
36regulation of sulfur metabolic process (GO:0042762)3.40291004
37peptidyl-arginine omega-N-methylation (GO:0035247)3.40254219
382-oxoglutarate metabolic process (GO:0006103)3.39399359
39succinate metabolic process (GO:0006105)3.37304326
40proline biosynthetic process (GO:0006561)3.33398581
41telomere maintenance via semi-conservative replication (GO:0032201)3.32506915
42cardiac muscle contraction (GO:0060048)3.31505947
43aspartate family amino acid catabolic process (GO:0009068)3.30712280
44signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.26574912
45intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.26574912
46IMP metabolic process (GO:0046040)3.26025277
47DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.25853560
48signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.24778138
49signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.24778138
50signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.24778138
51mitotic nuclear envelope disassembly (GO:0007077)3.23988369
52cell communication by electrical coupling (GO:0010644)3.23476522
53mitotic sister chromatid segregation (GO:0000070)3.22671043
54nucleobase biosynthetic process (GO:0046112)3.22305458
55signal transduction involved in DNA integrity checkpoint (GO:0072401)3.22023857
56signal transduction involved in DNA damage checkpoint (GO:0072422)3.22023857
57carnitine shuttle (GO:0006853)3.21192626
58regulation of mitochondrial translation (GO:0070129)3.19447256
59chaperone-mediated protein complex assembly (GO:0051131)3.18546612
60signal transduction involved in cell cycle checkpoint (GO:0072395)3.18157077
61positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.17258350
62nuclear pore organization (GO:0006999)3.16604807
63nuclear envelope disassembly (GO:0051081)3.14989974
64membrane disassembly (GO:0030397)3.14989974
65double-strand break repair via nonhomologous end joining (GO:0006303)3.13939700
66non-recombinational repair (GO:0000726)3.13939700
67DNA replication-dependent nucleosome assembly (GO:0006335)3.08915939
68DNA replication-dependent nucleosome organization (GO:0034723)3.08915939
69* ATP synthesis coupled proton transport (GO:0015986)3.08340533
70* energy coupled proton transport, down electrochemical gradient (GO:0015985)3.08340533
71cardiac muscle cell development (GO:0055013)3.08338920
72plasma membrane repair (GO:0001778)3.07240221
73peptidyl-lysine dimethylation (GO:0018027)3.05989617
74protein localization to kinetochore (GO:0034501)3.05615863
75de novo protein folding (GO:0006458)3.04726266
76muscle filament sliding (GO:0030049)3.03797861
77actin-myosin filament sliding (GO:0033275)3.03797861
78DNA damage response, detection of DNA damage (GO:0042769)3.03570434
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01019788
80gluconeogenesis (GO:0006094)3.00244489
81negative regulation of cell size (GO:0045792)3.00021381
82positive regulation of ligase activity (GO:0051351)2.99667564
83de novo posttranslational protein folding (GO:0051084)2.99011639
84regulation of ubiquitin-protein transferase activity (GO:0051438)2.98023641
85purine nucleobase biosynthetic process (GO:0009113)2.97144692
86regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.96851404
87protein maturation by protein folding (GO:0022417)2.95848858
88glycolytic process (GO:0006096)2.94575016
89sister chromatid segregation (GO:0000819)2.93914411
90histone arginine methylation (GO:0034969)2.92678259
91DNA ligation (GO:0006266)2.91964650
92peptidyl-arginine N-methylation (GO:0035246)2.91862312
93peptidyl-arginine methylation (GO:0018216)2.91862312
94membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.91546529
95nucleobase-containing small molecule interconversion (GO:0015949)2.91494281
96nuclear pore complex assembly (GO:0051292)2.90443473
97branched-chain amino acid catabolic process (GO:0009083)2.87795008
98mitotic metaphase plate congression (GO:0007080)2.87673689
99positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.85821666
100DNA replication initiation (GO:0006270)2.85736773
101mitotic chromosome condensation (GO:0007076)2.85318517
102spliceosomal snRNP assembly (GO:0000387)2.84408023
103DNA strand elongation involved in DNA replication (GO:0006271)2.83966128
104regulation of ligase activity (GO:0051340)2.83962071
105L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.83499393
106cardiac cell development (GO:0055006)2.83012769
107ventricular cardiac muscle cell action potential (GO:0086005)2.82033992
108mitotic G1 DNA damage checkpoint (GO:0031571)2.81566055
109cell communication involved in cardiac conduction (GO:0086065)2.76988934
110sodium ion export (GO:0071436)2.75212015
111hexose biosynthetic process (GO:0019319)2.75034378
112mitochondrial RNA metabolic process (GO:0000959)2.73340975
113protein targeting to mitochondrion (GO:0006626)2.73153261
114formation of translation preinitiation complex (GO:0001731)2.72062283
115pentose-phosphate shunt (GO:0006098)2.71711912
116myofibril assembly (GO:0030239)2.71177850
117telomere maintenance via recombination (GO:0000722)2.70789104
118NADPH regeneration (GO:0006740)2.70278517
119pore complex assembly (GO:0046931)2.70201958
120galactose catabolic process (GO:0019388)2.69142354
121regulation of translational elongation (GO:0006448)2.68976882
122serine family amino acid biosynthetic process (GO:0009070)2.67658745
123fatty acid transmembrane transport (GO:1902001)2.64927263
124histone H2A acetylation (GO:0043968)2.64801907
125mitotic recombination (GO:0006312)2.64590352
126ventricular cardiac muscle cell development (GO:0055015)2.64458722
127retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.63815481
128regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.63249464
129mitochondrial fusion (GO:0008053)2.63097310
130pyruvate metabolic process (GO:0006090)2.62817186
131regulation of cellular amine metabolic process (GO:0033238)2.60273223
132nuclear envelope reassembly (GO:0031468)2.60083574
133mitotic nuclear envelope reassembly (GO:0007084)2.60083574
134protein localization to mitochondrion (GO:0070585)2.60022506
135membrane repolarization during action potential (GO:0086011)2.59942233
136DNA strand elongation (GO:0022616)2.59724336
137COPI coating of Golgi vesicle (GO:0048205)2.59427219
138Golgi transport vesicle coating (GO:0048200)2.59427219
139regulation of fatty acid oxidation (GO:0046320)2.57814424
140DNA duplex unwinding (GO:0032508)2.57572543
141tRNA aminoacylation for protein translation (GO:0006418)2.56435086
142monosaccharide biosynthetic process (GO:0046364)2.54408635
143DNA geometric change (GO:0032392)2.54246795
144actomyosin structure organization (GO:0031032)2.53628802
145negative regulation of microtubule polymerization (GO:0031115)2.53427899
146* purine nucleoside monophosphate biosynthetic process (GO:0009127)2.53260451
147* purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.53260451
148nuclear envelope organization (GO:0006998)2.53195229
149spliceosomal tri-snRNP complex assembly (GO:0000244)2.52799676
150amino acid activation (GO:0043038)2.49465822
151tRNA aminoacylation (GO:0043039)2.49465822
152pre-miRNA processing (GO:0031054)2.48571871
153ribosome assembly (GO:0042255)2.47914299
154epithelial cell-cell adhesion (GO:0090136)2.46236598
155* respiratory electron transport chain (GO:0022904)2.45083434
156carnitine transport (GO:0015879)2.44840682
157amino-acid betaine transport (GO:0015838)2.44840682

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.04927476
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.44598185
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.84528689
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.77296879
5* MYC_18555785_ChIP-Seq_MESCs_Mouse3.76187237
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.28249034
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.85777606
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71195005
9* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.60744144
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59650274
11ZNF263_19887448_ChIP-Seq_K562_Human2.55691109
12AR_21909140_ChIP-Seq_LNCAP_Human2.47445561
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28772510
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28064132
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21148767
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18252995
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.15496290
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.10180003
19ESR1_15608294_ChIP-ChIP_MCF-7_Human2.06162814
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02685177
21* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.01243704
22* XRN2_22483619_ChIP-Seq_HELA_Human2.00859651
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.91175985
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90938681
25* SRF_21415370_ChIP-Seq_HL-1_Mouse1.86314040
26STAT3_1855785_ChIP-Seq_MESCs_Mouse1.86068694
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.85512828
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84703781
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83645251
30MYC_22102868_ChIP-Seq_BL_Human1.81644009
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78949936
32CLOCK_20551151_ChIP-Seq_293T_Human1.78589094
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.77704459
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.75494846
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74940502
36* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74350542
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74344686
38ELK1_19687146_ChIP-ChIP_HELA_Human1.72641261
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72293383
40* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72118738
41* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.71371628
42* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64222914
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63899939
44CIITA_25753668_ChIP-Seq_RAJI_Human1.61236903
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58416131
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55925697
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54800872
48KLF4_18555785_ChIP-Seq_MESCs_Mouse1.53375441
49* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52789405
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52677919
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51382562
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51175704
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.50084057
54* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47847862
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.43978959
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43905235
57ATF3_27146783_Chip-Seq_COLON_Human1.43522739
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41576280
59GABP_19822575_ChIP-Seq_HepG2_Human1.41090480
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40274526
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.38179576
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36666963
63* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33059976
64* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32973861
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.30953062
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30202610
67DCP1A_22483619_ChIP-Seq_HELA_Human1.29478529
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28024640
69TTF2_22483619_ChIP-Seq_HELA_Human1.26840017
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24287465
71CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24107643
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21158294
73* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20806797
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19886871
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18392071
76ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.18093910
77TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.17749755
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.16526539
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14292516
80KDM5A_27292631_Chip-Seq_BREAST_Human1.14113621
81* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13820964
82SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.12600438
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12516590
84* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11226763
85SOX17_20123909_ChIP-Seq_XEN_Mouse1.11208952
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10204289
87* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09910426
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09860781
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09784117
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09704004
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09299883
92RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07569449
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06184777
94* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06146597
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05895272
96CHD1_26751641_Chip-Seq_LNCaP_Human1.05019349
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04591537
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04124581
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03577017
100* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03535925
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02705570
102NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02569385
103MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.00552125
104CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99593319
105SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98680115
106FOXP3_21729870_ChIP-Seq_TREG_Human0.98673408
107GABP_17652178_ChIP-ChIP_JURKAT_Human0.98550329
108* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98243278
109YY1_21170310_ChIP-Seq_MESCs_Mouse0.97114206
110P68_20966046_ChIP-Seq_HELA_Human0.96249332
111VDR_23849224_ChIP-Seq_CD4+_Human0.94842818
112TFEB_21752829_ChIP-Seq_HELA_Human0.94681359
113GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.93154598
114TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93094453
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92893538
116* FOXP1_21924763_ChIP-Seq_HESCs_Human0.91847077
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91237583
118* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91175318
119PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91110554
120RACK7_27058665_Chip-Seq_MCF-7_Human0.90585913
121ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90546505
122CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90383950
123* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90303431
124SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89541803
125TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.87864696
126MYC_18940864_ChIP-ChIP_HL60_Human0.86222685

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle3.88598845
2MP0002837_dystrophic_cardiac_calcinosis3.47081023
3MP0008058_abnormal_DNA_repair3.31731008
4MP0004215_abnormal_myocardial_fiber3.14331874
5MP0000751_myopathy3.06095973
6MP0003646_muscle_fatigue2.98298668
7MP0004233_abnormal_muscle_weight2.60741552
8MP0005330_cardiomyopathy2.56249630
9MP0003123_paternal_imprinting2.53996637
10MP0003705_abnormal_hypodermis_morpholog2.49170898
11MP0004036_abnormal_muscle_relaxation2.39476531
12MP0010352_gastrointestinal_tract_polyps2.37645686
13MP0004957_abnormal_blastocyst_morpholog2.25383388
14MP0004087_abnormal_muscle_fiber2.22088318
15MP0002269_muscular_atrophy2.18559597
16MP0003221_abnormal_cardiomyocyte_apopto2.13010005
17MP0001529_abnormal_vocalization2.12659796
18MP0003806_abnormal_nucleotide_metabolis2.07814828
19MP0000749_muscle_degeneration2.06571368
20MP0010234_abnormal_vibrissa_follicle2.00926857
21MP0001730_embryonic_growth_arrest2.00779202
22MP0008775_abnormal_heart_ventricle1.98811657
23MP0003693_abnormal_embryo_hatching1.95411386
24MP0000537_abnormal_urethra_morphology1.94643992
25MP0003941_abnormal_skin_development1.90709692
26MP0000750_abnormal_muscle_regeneration1.90018643
27MP0003111_abnormal_nucleus_morphology1.88006069
28MP0006036_abnormal_mitochondrial_physio1.86234304
29MP0000747_muscle_weakness1.85279426
30MP0004130_abnormal_muscle_cell1.84354867
31MP0002972_abnormal_cardiac_muscle1.82404508
32MP0010630_abnormal_cardiac_muscle1.80719956
33MP0010094_abnormal_chromosome_stability1.80222300
34MP0003718_maternal_effect1.79190876
35MP0005451_abnormal_body_composition1.74298076
36MP0003186_abnormal_redox_activity1.74187693
37MP0003137_abnormal_impulse_conducting1.73256649
38MP0009697_abnormal_copulation1.72571458
39MP0003567_abnormal_fetal_cardiomyocyte1.72128028
40MP0003283_abnormal_digestive_organ1.70868606
41MP0003077_abnormal_cell_cycle1.69198972
42MP0005666_abnormal_adipose_tissue1.67481473
43MP0006138_congestive_heart_failure1.63669516
44MP0005385_cardiovascular_system_phenoty1.62462915
45MP0001544_abnormal_cardiovascular_syste1.62462915
46MP0005620_abnormal_muscle_contractility1.61549424
47MP0000372_irregular_coat_pigmentation1.57351951
48MP0003786_premature_aging1.54065956
49MP0002106_abnormal_muscle_physiology1.46112439
50MP0004185_abnormal_adipocyte_glucose1.43232410
51MP0003984_embryonic_growth_retardation1.42930726
52MP0005394_taste/olfaction_phenotype1.41851764
53MP0005499_abnormal_olfactory_system1.41851764
54MP0002088_abnormal_embryonic_growth/wei1.40511065
55MP0001697_abnormal_embryo_size1.40252397
56MP0008789_abnormal_olfactory_epithelium1.39843779
57MP0000759_abnormal_skeletal_muscle1.38945042
58MP0005187_abnormal_penis_morphology1.38242652
59MP0005380_embryogenesis_phenotype1.36526543
60MP0001672_abnormal_embryogenesis/_devel1.36526543
61MP0006035_abnormal_mitochondrial_morpho1.34177860
62MP0001727_abnormal_embryo_implantation1.30481184
63MP0002080_prenatal_lethality1.29267004
64MP0002084_abnormal_developmental_patter1.27389218
65MP0004197_abnormal_fetal_growth/weight/1.25653322
66MP0004043_abnormal_pH_regulation1.22934860
67MP0000350_abnormal_cell_proliferation1.22318503
68MP0004484_altered_response_of1.21021559
69MP0003315_abnormal_perineum_morphology1.19666697
70MP0008260_abnormal_autophagy1.19372090
71MP0005375_adipose_tissue_phenotype1.18373738
72MP0005670_abnormal_white_adipose1.15844017
73MP0005076_abnormal_cell_differentiation1.14286338
74MP0005266_abnormal_metabolism1.14001287
75MP0005369_muscle_phenotype1.13996334
76MP0002102_abnormal_ear_morphology1.12852727
77MP0002086_abnormal_extraembryonic_tissu1.12614191
78MP0004145_abnormal_muscle_electrophysio1.11350359
79MP0002085_abnormal_embryonic_tissue1.11159791
80MP0002234_abnormal_pharynx_morphology1.10405226
81MP0001346_abnormal_lacrimal_gland1.09986536
82MP0003566_abnormal_cell_adhesion1.09892597
83MP0010307_abnormal_tumor_latency1.09750201
84MP0004085_abnormal_heartbeat1.08105299
85MP0000313_abnormal_cell_death1.06904536
86MP0000013_abnormal_adipose_tissue1.06449610
87MP0002909_abnormal_adrenal_gland1.06335920
88MP0004270_analgesia1.06004073
89MP0008932_abnormal_embryonic_tissue1.05878995
90MP0001661_extended_life_span1.05718148
91MP0005501_abnormal_skin_physiology1.05678059
92MP0000266_abnormal_heart_morphology1.05172304
93MP0009672_abnormal_birth_weight1.03651168
94MP0008961_abnormal_basal_metabolism1.03086071
95MP0010030_abnormal_orbit_morphology1.02820643
96MP0000003_abnormal_adipose_tissue1.01125462
97MP0000358_abnormal_cell_content/1.00609023
98MP0003119_abnormal_digestive_system0.99225682
99MP0002090_abnormal_vision0.97550729
100MP0002822_catalepsy0.95785604
101MP0003121_genomic_imprinting0.95387889
102MP0002127_abnormal_cardiovascular_syste0.94166055
103MP0008057_abnormal_DNA_replication0.93570567
104MP0000733_abnormal_muscle_development0.91846443
105MP0001984_abnormal_olfaction0.90978554
106MP0003878_abnormal_ear_physiology0.88867827
107MP0005377_hearing/vestibular/ear_phenot0.88867827
108MP0005408_hypopigmentation0.86312006
109MP0006054_spinal_hemorrhage0.83311728
110MP0005332_abnormal_amino_acid0.82384913
111MP0001764_abnormal_homeostasis0.82201485
112MP0005623_abnormal_meninges_morphology0.80760073
113MP0009703_decreased_birth_body0.80016262
114MP0002089_abnormal_postnatal_growth/wei0.79862649
115MP0004264_abnormal_extraembryonic_tissu0.79334515
116MP0009053_abnormal_anal_canal0.78646819
117MP0004782_abnormal_surfactant_physiolog0.76162187
118MP0003122_maternal_imprinting0.75937439
119MP0008007_abnormal_cellular_replicative0.75654384
120MP0002938_white_spotting0.74337537
121MP0008877_abnormal_DNA_methylation0.73168366
122MP0000566_synostosis0.73032112
123MP0003880_abnormal_central_pattern0.72344585
124MP0001849_ear_inflammation0.72208210
125MP0005384_cellular_phenotype0.71863058
126MP0003890_abnormal_embryonic-extraembry0.70630262
127MP0002332_abnormal_exercise_endurance0.70363115
128MP0008995_early_reproductive_senescence0.68334973
129MP0002653_abnormal_ependyma_morphology0.68220507
130MP0005360_urolithiasis0.67499334
131MP0002796_impaired_skin_barrier0.67064041
132MP0005248_abnormal_Harderian_gland0.65932899
133MP0002970_abnormal_white_adipose0.65274372
134MP0003115_abnormal_respiratory_system0.65074259
135MP0004147_increased_porphyrin_level0.64898548
136MP0000647_abnormal_sebaceous_gland0.63977570
137MP0008770_decreased_survivor_rate0.63933835
138MP0004859_abnormal_synaptic_plasticity0.63868225
139MP0002877_abnormal_melanocyte_morpholog0.63578310
140MP0004272_abnormal_basement_membrane0.62738786
141MP0003937_abnormal_limbs/digits/tail_de0.61808992
142MP0002697_abnormal_eye_size0.61299622
143MP0002210_abnormal_sex_determination0.61255055
144MP0001756_abnormal_urination0.60857861
145MP0001929_abnormal_gametogenesis0.60446893
146MP0002736_abnormal_nociception_after0.59828412

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)4.65925457
2Abnormal gallbladder physiology (HP:0012438)4.65925457
3Sudden death (HP:0001699)4.25562875
4Myoglobinuria (HP:0002913)4.16229453
5Exercise-induced muscle cramps (HP:0003710)3.93834300
6Microvesicular hepatic steatosis (HP:0001414)3.69781201
7Rhabdomyolysis (HP:0003201)3.60434002
8Cortical dysplasia (HP:0002539)3.14523688
9Ependymoma (HP:0002888)3.13359170
10Angiofibromas (HP:0010615)3.11237642
11Adenoma sebaceum (HP:0009720)3.11237642
12Ventricular tachycardia (HP:0004756)3.03777557
13Exercise-induced myalgia (HP:0003738)3.02560943
14Degeneration of anterior horn cells (HP:0002398)2.94324675
15Abnormality of the anterior horn cell (HP:0006802)2.94324675
16Palpitations (HP:0001962)2.91576138
17Ventricular fibrillation (HP:0001663)2.88783201
18Cerebral hypomyelination (HP:0006808)2.87065694
19Ketoacidosis (HP:0001993)2.84985275
20Ragged-red muscle fibers (HP:0003200)2.81101144
21Hypoglycemic coma (HP:0001325)2.76893869
22Increased serum lactate (HP:0002151)2.71989486
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71005114
24Abnormality of alanine metabolism (HP:0010916)2.71005114
25Hyperalaninemia (HP:0003348)2.71005114
26Right ventricular cardiomyopathy (HP:0011663)2.68165057
27Lipoatrophy (HP:0100578)2.64326703
28Neoplasm of the adrenal gland (HP:0100631)2.63724658
29Increased intramyocellular lipid droplets (HP:0012240)2.60205169
30Abnormality of glycolysis (HP:0004366)2.59161876
31Increased serum pyruvate (HP:0003542)2.59161876
32Exercise intolerance (HP:0003546)2.56669401
33Multiple enchondromatosis (HP:0005701)2.55326467
34Cholelithiasis (HP:0001081)2.53349728
35Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53237557
36Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53237557
37Mitochondrial inheritance (HP:0001427)2.51531317
38Bundle branch block (HP:0011710)2.51374253
39Subaortic stenosis (HP:0001682)2.51186265
40Abnormality of the left ventricular outflow tract (HP:0011103)2.51186265
41Conjunctival hamartoma (HP:0100780)2.49022637
42Atrial fibrillation (HP:0005110)2.46507074
43Abnormal gallbladder morphology (HP:0012437)2.44726432
44Abnormality of the astrocytes (HP:0100707)2.42405707
45Astrocytoma (HP:0009592)2.42405707
46Supraventricular tachycardia (HP:0004755)2.41407208
47Postnatal microcephaly (HP:0005484)2.41068372
48Type I transferrin isoform profile (HP:0003642)2.40384316
49Supraventricular arrhythmia (HP:0005115)2.39728737
50Primary atrial arrhythmia (HP:0001692)2.39290893
51Ventricular arrhythmia (HP:0004308)2.38773359
52Increased connective tissue (HP:0009025)2.38308290
53Progressive muscle weakness (HP:0003323)2.37878824
54Dysmetric saccades (HP:0000641)2.37675959
55Hepatic necrosis (HP:0002605)2.36772445
56Difficulty climbing stairs (HP:0003551)2.34627679
57Hyperglycinuria (HP:0003108)2.33677350
58Athetosis (HP:0002305)2.33312461
59Hyporeflexia of lower limbs (HP:0002600)2.32187907
60Pheochromocytoma (HP:0002666)2.30416235
61Neoplasm of the rectum (HP:0100743)2.29998047
62Muscle fiber splitting (HP:0003555)2.29435960
63Lymphangioma (HP:0100764)2.28408284
64Upper limb muscle weakness (HP:0003484)2.28372713
65Limb-girdle muscle atrophy (HP:0003797)2.27675267
66Abnormality of the calf musculature (HP:0001430)2.27655062
67Calf muscle hypertrophy (HP:0008981)2.27400978
68Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25640585
69Syncope (HP:0001279)2.23944391
70Increased hepatocellular lipid droplets (HP:0006565)2.23645603
71Hamartoma of the eye (HP:0010568)2.19663957
72Abnormal mitochondria in muscle tissue (HP:0008316)2.18787558
73Colon cancer (HP:0003003)2.17762425
74Prolonged QT interval (HP:0001657)2.17638144
75Lipid accumulation in hepatocytes (HP:0006561)2.16001055
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15854325
77Dicarboxylic aciduria (HP:0003215)2.15854325
78Chromsome breakage (HP:0040012)2.15359733
79Hyperammonemia (HP:0001987)2.15105185
80Progressive macrocephaly (HP:0004481)2.15093863
81Hypokinesia (HP:0002375)2.14556863
82Abnormality of fatty-acid metabolism (HP:0004359)2.13936158
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13586382
84Abnormal protein N-linked glycosylation (HP:0012347)2.13586382
85Abnormal protein glycosylation (HP:0012346)2.13586382
86Abnormal glycosylation (HP:0012345)2.13586382
87Dilated cardiomyopathy (HP:0001644)2.13572817
88Emotional lability (HP:0000712)2.12159238
89Ketosis (HP:0001946)2.11834358
90Difficulty running (HP:0009046)2.11614840
91Abnormality of the labia minora (HP:0012880)2.10522257
92CNS hypomyelination (HP:0003429)2.09470672
93Hyperglycinemia (HP:0002154)2.07105853
94Abnormality of glycine metabolism (HP:0010895)2.06142150
95Abnormality of serine family amino acid metabolism (HP:0010894)2.06142150
96Nemaline bodies (HP:0003798)2.04782695
97Neoplasm of the small intestine (HP:0100833)2.02534423
98Increased muscle lipid content (HP:0009058)2.01969215
99Hand muscle atrophy (HP:0009130)2.01762703
100Fibroma (HP:0010614)2.01176844
101Reduced antithrombin III activity (HP:0001976)1.98789379
102Neoplasm of the peripheral nervous system (HP:0100007)1.98764494
103Hyperacusis (HP:0010780)1.97267976
104Upper limb amyotrophy (HP:0009129)1.96624378
105Distal upper limb amyotrophy (HP:0007149)1.96624378
106Rimmed vacuoles (HP:0003805)1.96483288
107Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.95839925
108EMG: myopathic abnormalities (HP:0003458)1.95742052
109Gout (HP:0001997)1.95181335
110Abnormality of the gallbladder (HP:0005264)1.94519234
111Intestinal polyposis (HP:0200008)1.93966274
112Neuroendocrine neoplasm (HP:0100634)1.93462544
113Hepatocellular necrosis (HP:0001404)1.93004863
114Atrioventricular block (HP:0001678)1.92783488
115Pelvic girdle muscle weakness (HP:0003749)1.92201059
116CNS demyelination (HP:0007305)1.92018021
117Respiratory failure (HP:0002878)1.91954287
118Muscle hypertrophy of the lower extremities (HP:0008968)1.91297549
119Muscle fiber inclusion bodies (HP:0100299)1.91084283
120Spastic diplegia (HP:0001264)1.91078899
121Intestinal polyp (HP:0005266)1.90224000
122Abnormality of serum amino acid levels (HP:0003112)1.89990726
123Secondary amenorrhea (HP:0000869)1.89333500
124Myotonia (HP:0002486)1.89249618
125Fibrous tissue neoplasm (HP:0012316)1.88750584
126Acute encephalopathy (HP:0006846)1.87395139
127Lethargy (HP:0001254)1.87353220
128Shoulder girdle muscle weakness (HP:0003547)1.85311116
129Abnormality of methionine metabolism (HP:0010901)1.84286900
130Glioma (HP:0009733)1.83642277
131Ovarian neoplasm (HP:0100615)1.82903183
132Centrally nucleated skeletal muscle fibers (HP:0003687)1.82755970
133Lactic acidosis (HP:0003128)1.82591370
134Biliary tract neoplasm (HP:0100574)1.82531563
135Muscle stiffness (HP:0003552)1.82348183
136Atrophy/Degeneration involving motor neurons (HP:0007373)1.82055017
137Abnormality of the lower motor neuron (HP:0002366)1.81252043
138Heart block (HP:0012722)1.80041964
139Type 1 muscle fiber predominance (HP:0003803)1.79902970
140Cerebral edema (HP:0002181)1.79725054
141Rectal prolapse (HP:0002035)1.79014786
142Acute necrotizing encephalopathy (HP:0006965)1.78057910
143Increased CSF lactate (HP:0002490)1.78003185
144Birth length less than 3rd percentile (HP:0003561)1.77233999
145Progressive external ophthalmoplegia (HP:0000590)1.76821519
146Asymmetric septal hypertrophy (HP:0001670)1.76022445
147Insomnia (HP:0100785)1.75102108
148Myopathic facies (HP:0002058)1.74432325
149Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72165468
150Reticulocytosis (HP:0001923)1.71140566
151Abnormality of the hip-girdle musculature (HP:0001445)1.70312710
152Abnormality of the musculature of the pelvis (HP:0001469)1.70312710
153Increased nuchal translucency (HP:0010880)1.69080030
154Spastic paraparesis (HP:0002313)1.64266525
155Unsteady gait (HP:0002317)1.62853649
156Insidious onset (HP:0003587)1.61493981
157Termporal pattern (HP:0011008)1.61493981
158Leukodystrophy (HP:0002415)1.61298730
159Poor suck (HP:0002033)1.59754190
160Abnormality of the preputium (HP:0100587)1.58401834
161Fasciculations (HP:0002380)1.55929979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.77702757
2PKN23.66896931
3PBK3.52697093
4SRPK13.51929599
5TRIB33.31573011
6PDK32.81591621
7PDK42.81591621
8VRK22.64058155
9TTN2.47680295
10CDC72.47294608
11SCYL22.45054571
12LMTK22.43204087
13TRIM282.43057961
14EIF2AK32.35822558
15WEE12.27649969
16BCKDK2.26378061
17EEF2K2.25737762
18NME21.77681766
19BCR1.70313036
20NEK21.61128056
21BUB11.59274035
22KSR21.58321504
23OBSCN1.47536509
24PIM21.45678372
25TTK1.44182175
26EIF2AK11.43261661
27TESK11.42176126
28STK161.41643606
29NME11.41108311
30TESK21.37237359
31KSR11.30138019
32MAP3K101.28255252
33CSNK1G31.28232418
34TSSK61.26023712
35PDK21.24934973
36LATS21.24557673
37RPS6KB21.23338755
38RIPK11.21807044
39PAK41.20712588
40FLT31.20035627
41CCNB11.18533016
42MAP3K121.15837278
43MAPKAPK31.15283842
44BRSK21.15103349
45WNK31.14215794
46SMG11.13935961
47CSNK1A1L1.12912369
48PHKG21.10843190
49PHKG11.10843190
50ARAF1.10207546
51BRSK11.06117687
52SIK31.05677695
53PLK41.04383594
54LIMK11.04249133
55ILK1.03657383
56MAP3K81.02411427
57LRRK21.00437595
58CSNK1G10.99727508
59MAP3K90.98985030
60PASK0.95970111
61DMPK0.92946461
62MINK10.92153527
63MYLK0.92027628
64PRKD30.91756681
65PDGFRA0.91671448
66TGFBR10.91579952
67ALK0.91199212
68MAP4K20.87677481
69CSNK1G20.87580896
70PAK60.86452195
71WNK40.83938168
72PLK10.83667598
73MKNK10.82629660
74AURKB0.82458702
75MST40.81986557
76CDK40.81914552
77MAP2K70.81433866
78MST1R0.80055568
79PLK30.79106082
80CAMK1D0.78774336
81ERBB30.77058249
82ACVR1B0.75319496
83PAK30.75200052
84FGFR10.74801026
85STK38L0.74325717
86CAMKK10.74035833
87MTOR0.72214621
88VRK10.71896089
89EPHA20.69841395
90BRAF0.69448203
91STK380.68747950
92AKT20.68549692
93PTK60.68524387
94EIF2AK20.67413410
95ATR0.67210443
96MAP3K40.65205175
97EPHA40.64740175
98AURKA0.59988130
99CDK120.59790381
100MAP3K50.57147615
101CHEK10.56681723
102DAPK30.56260774
103CLK10.54338038
104CDK80.53978082
105ZAK0.53706742
106MAP3K110.53565077
107PAK20.53555176
108ATM0.53195318
109SIK10.52303168
110RAF10.51944493
111LATS10.51325864
112DYRK20.50705576
113MARK10.50352449
114MAP2K10.50058045
115RET0.49660527
116CDK140.49277570
117PNCK0.48306319
118TLK10.47732623
119ERBB40.47376273
120CDC42BPA0.47209770
121CDK10.45681600
122ICK0.45473467
123CSNK2A20.45197355
124CDK150.44770031
125CDK60.43949275
126CDK180.43733939
127CSNK1E0.43625501
128TAF10.43363335
129CSNK2A10.43090116
130PLK20.42985888
131CDK20.42751706
132TAOK10.41335455
133KDR0.40458729
134RPS6KA40.40313083
135PRKAA10.40292124
136FER0.39999946
137CDK70.39584239
138CDK11A0.39206196
139CAMK2G0.38992451
140PAK10.38693128
141PTK20.38503190
142ROCK10.38288466
143DAPK10.37880434
144CHEK20.37418592

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.82039425
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.61414629
3Carbon metabolism_Homo sapiens_hsa012002.96993206
4Propanoate metabolism_Homo sapiens_hsa006402.42159704
5Biosynthesis of amino acids_Homo sapiens_hsa012302.40708973
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.35144192
7Pyruvate metabolism_Homo sapiens_hsa006202.26876199
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.26297064
9DNA replication_Homo sapiens_hsa030302.23069509
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16653186
11Cardiac muscle contraction_Homo sapiens_hsa042602.16384655
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.14883063
13Fatty acid elongation_Homo sapiens_hsa000622.12420396
14Fatty acid degradation_Homo sapiens_hsa000712.00747207
15Non-homologous end-joining_Homo sapiens_hsa034501.94215530
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85225192
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78213587
18Mismatch repair_Homo sapiens_hsa034301.75018097
19Parkinsons disease_Homo sapiens_hsa050121.70554319
20Nitrogen metabolism_Homo sapiens_hsa009101.65437686
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57360616
22One carbon pool by folate_Homo sapiens_hsa006701.50031037
23RNA transport_Homo sapiens_hsa030131.48941237
24Fatty acid metabolism_Homo sapiens_hsa012121.45238811
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44699477
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.41817976
27RNA polymerase_Homo sapiens_hsa030201.41595181
28Steroid biosynthesis_Homo sapiens_hsa001001.39997595
29Butanoate metabolism_Homo sapiens_hsa006501.39006152
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.27863819
31* Oxidative phosphorylation_Homo sapiens_hsa001901.26046405
32Protein export_Homo sapiens_hsa030601.24999135
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.23460472
34Dilated cardiomyopathy_Homo sapiens_hsa054141.21550271
35Vitamin B6 metabolism_Homo sapiens_hsa007501.20002060
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19333129
37Cell cycle_Homo sapiens_hsa041101.18271278
38Huntingtons disease_Homo sapiens_hsa050161.14010641
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12453705
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11790768
41Oocyte meiosis_Homo sapiens_hsa041141.10742995
42Pentose phosphate pathway_Homo sapiens_hsa000301.08157943
43Fructose and mannose metabolism_Homo sapiens_hsa000511.01071612
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99019018
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98254675
46Spliceosome_Homo sapiens_hsa030400.97728471
47Glucagon signaling pathway_Homo sapiens_hsa049220.96464308
48Fanconi anemia pathway_Homo sapiens_hsa034600.93603170
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92565538
50Alzheimers disease_Homo sapiens_hsa050100.90778602
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89553403
52Arginine biosynthesis_Homo sapiens_hsa002200.88277331
53Folate biosynthesis_Homo sapiens_hsa007900.86845349
54Purine metabolism_Homo sapiens_hsa002300.84858137
55Sulfur metabolism_Homo sapiens_hsa009200.84855249
56Phenylalanine metabolism_Homo sapiens_hsa003600.84502960
57Vibrio cholerae infection_Homo sapiens_hsa051100.83138972
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82999650
59Selenocompound metabolism_Homo sapiens_hsa004500.82730365
60Proteasome_Homo sapiens_hsa030500.82682651
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79127742
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79038034
63Galactose metabolism_Homo sapiens_hsa000520.78897533
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78661241
65Insulin signaling pathway_Homo sapiens_hsa049100.77566395
66AMPK signaling pathway_Homo sapiens_hsa041520.73843631
67Nucleotide excision repair_Homo sapiens_hsa034200.73516973
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73335131
69N-Glycan biosynthesis_Homo sapiens_hsa005100.70604450
70Lysine degradation_Homo sapiens_hsa003100.70073973
71Base excision repair_Homo sapiens_hsa034100.68987180
72* Metabolic pathways_Homo sapiens_hsa011000.67574189
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66665410
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66501288
75PPAR signaling pathway_Homo sapiens_hsa033200.66178787
76Basal transcription factors_Homo sapiens_hsa030220.66131569
77Thyroid cancer_Homo sapiens_hsa052160.65755083
78mTOR signaling pathway_Homo sapiens_hsa041500.65463725
79HIF-1 signaling pathway_Homo sapiens_hsa040660.65353448
80mRNA surveillance pathway_Homo sapiens_hsa030150.64887190
81Tight junction_Homo sapiens_hsa045300.63450896
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58857289
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56416872
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55791518
85Insulin resistance_Homo sapiens_hsa049310.55369414
86Synaptic vesicle cycle_Homo sapiens_hsa047210.55070672
87Peroxisome_Homo sapiens_hsa041460.54301012
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53100460
89Bladder cancer_Homo sapiens_hsa052190.49663896
90Pyrimidine metabolism_Homo sapiens_hsa002400.48828775
91Tyrosine metabolism_Homo sapiens_hsa003500.47223162
92beta-Alanine metabolism_Homo sapiens_hsa004100.46946276
93Viral myocarditis_Homo sapiens_hsa054160.46095222
94Bile secretion_Homo sapiens_hsa049760.44470899
95Fatty acid biosynthesis_Homo sapiens_hsa000610.43518466
96Long-term potentiation_Homo sapiens_hsa047200.43340805
97Tryptophan metabolism_Homo sapiens_hsa003800.43039155
98Ribosome_Homo sapiens_hsa030100.42774435
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42339296
100RNA degradation_Homo sapiens_hsa030180.42165834
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41852958
102Hippo signaling pathway_Homo sapiens_hsa043900.40369013
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39901694
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39640261
105Fat digestion and absorption_Homo sapiens_hsa049750.39622728
106Sulfur relay system_Homo sapiens_hsa041220.38731568
107Arginine and proline metabolism_Homo sapiens_hsa003300.38285337
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38131270
109Gastric acid secretion_Homo sapiens_hsa049710.37606245
110Gap junction_Homo sapiens_hsa045400.37271707
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36678228
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36018571
113Starch and sucrose metabolism_Homo sapiens_hsa005000.35272377
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.35160963
115Homologous recombination_Homo sapiens_hsa034400.34588924
116Glioma_Homo sapiens_hsa052140.34109969
117p53 signaling pathway_Homo sapiens_hsa041150.33808423
118Glycerolipid metabolism_Homo sapiens_hsa005610.33393584
119Endometrial cancer_Homo sapiens_hsa052130.32911969
120Alcoholism_Homo sapiens_hsa050340.32321694
121Glutathione metabolism_Homo sapiens_hsa004800.31550555
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.30957637
123Adherens junction_Homo sapiens_hsa045200.30790754
124Viral carcinogenesis_Homo sapiens_hsa052030.30636575
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29809372
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28981627
127Thyroid hormone synthesis_Homo sapiens_hsa049180.28103062
128Systemic lupus erythematosus_Homo sapiens_hsa053220.27644173
129Collecting duct acid secretion_Homo sapiens_hsa049660.23775724
130Epstein-Barr virus infection_Homo sapiens_hsa051690.14271533
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.11328771
132Vitamin digestion and absorption_Homo sapiens_hsa049770.08529159
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.04630486

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