ATP5BP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1growth hormone secretion (GO:0030252)8.17127888
2ganglion development (GO:0061548)7.43895479
3positive regulation of growth hormone secretion (GO:0060124)7.38450981
4response to gravity (GO:0009629)7.28838571
5negative regulation of oligodendrocyte differentiation (GO:0048715)6.71308150
6response to folic acid (GO:0051593)6.56648048
7cerebral cortex neuron differentiation (GO:0021895)6.03074673
8regulation of timing of cell differentiation (GO:0048505)5.86174870
9negative regulation of muscle hypertrophy (GO:0014741)5.73960717
10regulation of transcription involved in cell fate commitment (GO:0060850)5.55814716
11neuroblast proliferation (GO:0007405)5.37809474
12lung secretory cell differentiation (GO:0061140)5.25826773
13spinal cord association neuron differentiation (GO:0021527)5.14629899
14regulation of development, heterochronic (GO:0040034)5.04343354
15multicellular organismal movement (GO:0050879)4.97260279
16musculoskeletal movement (GO:0050881)4.97260279
17auditory behavior (GO:0031223)4.85733999
18skeletal muscle adaptation (GO:0043501)4.73516839
19muscle atrophy (GO:0014889)4.63959125
20sympathetic nervous system development (GO:0048485)4.58376647
21striated muscle atrophy (GO:0014891)4.57466974
22regulation of growth hormone secretion (GO:0060123)4.55231583
23cullin deneddylation (GO:0010388)4.52354567
24positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.34539929
25olfactory bulb development (GO:0021772)4.28621486
26reflex (GO:0060004)4.26009606
27protein deneddylation (GO:0000338)4.16933522
28RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.16406537
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.16406537
30neuron fate commitment (GO:0048663)4.09640701
31postsynaptic membrane organization (GO:0001941)4.03033875
32forebrain neuron differentiation (GO:0021879)3.91119974
33regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.86991462
34synaptic vesicle maturation (GO:0016188)3.86177492
35positive regulation of circadian rhythm (GO:0042753)3.85191319
36regulation of skeletal muscle contraction (GO:0014819)3.85103704
37mechanosensory behavior (GO:0007638)3.76844569
38positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.67763276
39dendritic spine morphogenesis (GO:0060997)3.58575132
40negative regulation of glial cell differentiation (GO:0045686)3.56764221
41neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.53838707
42microtubule nucleation (GO:0007020)3.50505174
43gamma-aminobutyric acid transport (GO:0015812)3.50032068
44response to muscle activity (GO:0014850)3.46696271
45hippocampus development (GO:0021766)3.46591570
46platelet dense granule organization (GO:0060155)3.44155279
47response to food (GO:0032094)3.43224584
48pyrimidine nucleobase catabolic process (GO:0006208)3.39951591
49oligodendrocyte development (GO:0014003)3.39265732
50glycine transport (GO:0015816)3.34954159
51central nervous system neuron development (GO:0021954)3.28481538
52glandular epithelial cell differentiation (GO:0002067)3.26788695
53behavioral response to ethanol (GO:0048149)3.26758478
54actin-myosin filament sliding (GO:0033275)3.25840915
55muscle filament sliding (GO:0030049)3.25840915
56regulation of oligodendrocyte differentiation (GO:0048713)3.25384184
57negative regulation of cAMP-mediated signaling (GO:0043951)3.24385671
58negative regulation of Notch signaling pathway (GO:0045746)3.21570423
59neuron fate specification (GO:0048665)3.15557912
60regulation of circadian sleep/wake cycle (GO:0042749)3.14953303
61regulation of circadian sleep/wake cycle, sleep (GO:0045187)3.14953303
62alternative mRNA splicing, via spliceosome (GO:0000380)3.13126369
63behavioral response to nicotine (GO:0035095)3.11149972
64regulation of vesicle fusion (GO:0031338)3.07320700
65response to auditory stimulus (GO:0010996)3.05614125
66positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.05123119
67positive regulation of endothelial cell differentiation (GO:0045603)3.02243382
68negative regulation of skeletal muscle tissue development (GO:0048642)2.96916976
69astrocyte differentiation (GO:0048708)2.92523279
70response to lithium ion (GO:0010226)2.89131267
71vocalization behavior (GO:0071625)2.85412967
72dosage compensation (GO:0007549)2.83657380
73skeletal muscle tissue regeneration (GO:0043403)2.81766103
74positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.79662886
75regulation of gene expression by genetic imprinting (GO:0006349)2.75201549
76negative regulation of acute inflammatory response (GO:0002674)2.74570431
77neuromuscular synaptic transmission (GO:0007274)2.71126632
78negative regulation of gliogenesis (GO:0014014)2.69510630
79response to inactivity (GO:0014854)2.66733792
80nucleobase catabolic process (GO:0046113)2.66470863
81regulation of isotype switching to IgG isotypes (GO:0048302)2.65374611
82regulation of voltage-gated calcium channel activity (GO:1901385)2.63674566
83regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.58463448
84negative regulation of amino acid transport (GO:0051956)2.57482391
85cellular potassium ion homeostasis (GO:0030007)2.55802048
86peristalsis (GO:0030432)2.55398100
87transmission of nerve impulse (GO:0019226)2.54151554
88positive regulation of interleukin-17 production (GO:0032740)2.53598994
89embryonic cranial skeleton morphogenesis (GO:0048701)2.53567857
90regulation of synaptic vesicle exocytosis (GO:2000300)2.52084056
91negative regulation of cytosolic calcium ion concentration (GO:0051481)2.48791378
92regulation of endothelial cell differentiation (GO:0045601)2.47814974
93circadian sleep/wake cycle process (GO:0022410)2.47457847
94prostate gland growth (GO:0060736)2.45707723
95actin-mediated cell contraction (GO:0070252)2.44526506
96glial cell development (GO:0021782)2.42973646
97neuron cell-cell adhesion (GO:0007158)2.42335630
98regulation of glycogen (starch) synthase activity (GO:2000465)2.41883775
99negative regulation of synaptic transmission, GABAergic (GO:0032229)2.38671135
100L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.38637320

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.43360839
2VDR_22108803_ChIP-Seq_LS180_Human4.23759838
3EZH2_22144423_ChIP-Seq_EOC_Human3.95799891
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.93395508
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.74007212
6TAF15_26573619_Chip-Seq_HEK293_Human2.89908508
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.77963335
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.68550124
9REST_21632747_ChIP-Seq_MESCs_Mouse2.30568687
10GBX2_23144817_ChIP-Seq_PC3_Human2.19860589
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19060893
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.16965316
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.16965316
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.16965316
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09471652
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.01295929
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.00805055
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.90529482
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89471596
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89274836
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87114794
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82222290
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77657995
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77657995
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77439658
26IGF1R_20145208_ChIP-Seq_DFB_Human1.76399599
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.75231477
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69751789
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67228600
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.62731467
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61408928
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.59320566
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57674054
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.57541302
35TP53_20018659_ChIP-ChIP_R1E_Mouse1.56209721
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51456976
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49020502
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48988205
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.48531135
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45834542
41CBP_20019798_ChIP-Seq_JUKART_Human1.45834542
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.45430525
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37778997
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37778997
45TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.37659980
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.36448933
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.36104560
48ZNF274_21170338_ChIP-Seq_K562_Hela1.35547811
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34412215
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31171303
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.27354039
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27127093
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26046882
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24966409
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.24603829
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23552871
57KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22380322
58CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.21448022
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17579955
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17192077
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16984627
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14567729
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14178620
64CIITA_25753668_ChIP-Seq_RAJI_Human1.13705464
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.12916509
66TP53_22573176_ChIP-Seq_HFKS_Human1.12520945
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12381103
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12245345
69FUS_26573619_Chip-Seq_HEK293_Human1.07629496
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.06756293
71SMAD4_21799915_ChIP-Seq_A2780_Human1.05984628
72P300_19829295_ChIP-Seq_ESCs_Human1.03555424
73SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01900451
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01537119
75MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01452302
76PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99559562
77JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.96574038
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93066119
79PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92643651
80PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92031448
81PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91697892
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91394282
83NCOR_22424771_ChIP-Seq_293T_Human0.91375970
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90251541
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90157819
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88568450
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86807150
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85428296
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84818572
90ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84732994
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84547646
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83807355
93ETS1_20019798_ChIP-Seq_JURKAT_Human0.83447846
94SMAD3_21741376_ChIP-Seq_EPCs_Human0.82300994
95SOX9_26525672_Chip-Seq_HEART_Mouse0.82223446
96STAT3_23295773_ChIP-Seq_U87_Human0.81332868
97GATA1_22025678_ChIP-Seq_K562_Human0.78563307
98VDR_23849224_ChIP-Seq_CD4+_Human0.78484521
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.77559070
100STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.77369922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy7.43950775
2MP0008789_abnormal_olfactory_epithelium4.96739215
3MP0005499_abnormal_olfactory_system3.95392490
4MP0005394_taste/olfaction_phenotype3.95392490
5MP0006072_abnormal_retinal_apoptosis2.99477769
6MP0001529_abnormal_vocalization2.98536732
7MP0001348_abnormal_lacrimal_gland2.87575741
8MP0001968_abnormal_touch/_nociception2.72286637
9MP0005646_abnormal_pituitary_gland2.69772525
10MP0004270_analgesia2.69297717
11MP0002095_abnormal_skin_pigmentation2.43539405
12MP0002735_abnormal_chemical_nociception2.33113290
13MP0009745_abnormal_behavioral_response2.08897953
14MP0005423_abnormal_somatic_nervous2.08037555
15MP0000013_abnormal_adipose_tissue2.05100262
16MP0002734_abnormal_mechanical_nocicepti2.00603610
17MP0004145_abnormal_muscle_electrophysio1.98740162
18MP0004885_abnormal_endolymph1.91961238
19MP0001986_abnormal_taste_sensitivity1.81245709
20MP0002736_abnormal_nociception_after1.81072109
21MP0005670_abnormal_white_adipose1.74393476
22MP0002102_abnormal_ear_morphology1.63350997
23MP0002733_abnormal_thermal_nociception1.60920218
24MP0000747_muscle_weakness1.59362984
25MP0002751_abnormal_autonomic_nervous1.58354163
26MP0008872_abnormal_physiological_respon1.54640725
27MP0003635_abnormal_synaptic_transmissio1.53511398
28MP0001984_abnormal_olfaction1.51045971
29MP0006276_abnormal_autonomic_nervous1.50721149
30MP0001905_abnormal_dopamine_level1.44928000
31MP0005253_abnormal_eye_physiology1.43059116
32MP0005645_abnormal_hypothalamus_physiol1.41453168
33MP0005386_behavior/neurological_phenoty1.37910878
34MP0004924_abnormal_behavior1.37910878
35MP0004036_abnormal_muscle_relaxation1.37700853
36MP0001502_abnormal_circadian_rhythm1.36086459
37MP0000049_abnormal_middle_ear1.36077484
38MP0002064_seizures1.34348916
39MP0001440_abnormal_grooming_behavior1.26165652
40MP0008995_early_reproductive_senescence1.25198312
41MP0004147_increased_porphyrin_level1.23090212
42MP0002089_abnormal_postnatal_growth/wei1.22519718
43MP0003705_abnormal_hypodermis_morpholog1.22079716
44MP0002184_abnormal_innervation1.21048929
45MP0003786_premature_aging1.20790419
46MP0000778_abnormal_nervous_system1.20543750
47MP0000631_abnormal_neuroendocrine_gland1.20120057
48MP0001188_hyperpigmentation1.20098014
49MP0000003_abnormal_adipose_tissue1.19927643
50MP0005083_abnormal_biliary_tract1.19385941
51MP0000566_synostosis1.19065411
52MP0002063_abnormal_learning/memory/cond1.18591889
53MP0002572_abnormal_emotion/affect_behav1.18540177
54MP0002272_abnormal_nervous_system1.17337644
55MP0001970_abnormal_pain_threshold1.16522795
56MP0000955_abnormal_spinal_cord1.14707416
57MP0000569_abnormal_digit_pigmentation1.11325661
58MP0003045_fibrosis1.09393323
59MP0002638_abnormal_pupillary_reflex1.09180688
60MP0002069_abnormal_eating/drinking_beha1.07318643
61MP0002876_abnormal_thyroid_physiology1.06857552
62MP0004142_abnormal_muscle_tone1.03577954
63MP0000427_abnormal_hair_cycle1.03377651
64MP0001270_distended_abdomen1.01743604
65MP0001486_abnormal_startle_reflex1.00506082
66MP0004811_abnormal_neuron_physiology1.00384562
67MP0000759_abnormal_skeletal_muscle1.00068833
68MP0003787_abnormal_imprinting1.00035669
69MP0002557_abnormal_social/conspecific_i0.98176484
70MP0003646_muscle_fatigue0.95956042
71MP0005409_darkened_coat_color0.95665926
72MP0004742_abnormal_vestibular_system0.94650580
73MP0004484_altered_response_of0.90829701
74MP0004859_abnormal_synaptic_plasticity0.85377123
75MP0000372_irregular_coat_pigmentation0.84712186
76MP0002882_abnormal_neuron_morphology0.83279930
77MP0001664_abnormal_digestion0.77957748
78MP0002138_abnormal_hepatobiliary_system0.75990192
79MP0002233_abnormal_nose_morphology0.74829087
80MP0002066_abnormal_motor_capabilities/c0.74785055
81MP0008877_abnormal_DNA_methylation0.73975245
82MP0003959_abnormal_lean_body0.71386328
83MP0009046_muscle_twitch0.69409118
84MP0002269_muscular_atrophy0.69269164
85MP0005167_abnormal_blood-brain_barrier0.69109411
86MP0003329_amyloid_beta_deposits0.68631363
87MP0005551_abnormal_eye_electrophysiolog0.68597414
88MP0005620_abnormal_muscle_contractility0.68149700
89MP0002067_abnormal_sensory_capabilities0.67378630
90MP0003938_abnormal_ear_development0.66939427
91MP0000604_amyloidosis0.65304219
92MP0000749_muscle_degeneration0.64963733
93MP0004215_abnormal_myocardial_fiber0.64150200
94MP0005084_abnormal_gallbladder_morpholo0.63690679
95MP0002075_abnormal_coat/hair_pigmentati0.61004989
96MP0001943_abnormal_respiration0.58536273
97MP0002152_abnormal_brain_morphology0.55147464
98MP0000537_abnormal_urethra_morphology0.54684536
99MP0001756_abnormal_urination0.53344783
100MP0002752_abnormal_somatic_nervous0.51347280

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)5.39899750
2Hypoventilation (HP:0002791)4.72688889
3Action tremor (HP:0002345)4.35623735
4Abnormality of alanine metabolism (HP:0010916)3.73906915
5Hyperalaninemia (HP:0003348)3.73906915
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.73906915
7Mask-like facies (HP:0000298)3.22973947
8Absent speech (HP:0001344)3.09632815
9Deformed tarsal bones (HP:0008119)3.06845739
10Neuroblastic tumors (HP:0004376)3.01266795
11Peripheral primitive neuroectodermal neoplasm (HP:0030067)3.01266795
12Neuroblastoma (HP:0003006)3.01266795
13Primitive neuroectodermal tumor (HP:0030065)3.01266795
14Calcaneovalgus deformity (HP:0001848)3.00118669
15Aqueductal stenosis (HP:0002410)2.98839484
16Mutism (HP:0002300)2.96866677
17Poor speech (HP:0002465)2.93160107
18Progressive cerebellar ataxia (HP:0002073)2.93147654
19Myopathic facies (HP:0002058)2.91970210
20Abnormality of the columella (HP:0009929)2.87184705
21Decreased electroretinogram (ERG) amplitude (HP:0000654)2.75124655
22Congenital sensorineural hearing impairment (HP:0008527)2.73998753
23Hypsarrhythmia (HP:0002521)2.63346783
24EEG with generalized epileptiform discharges (HP:0011198)2.60557823
25Chronic hepatic failure (HP:0100626)2.59733362
26Epileptic encephalopathy (HP:0200134)2.59244261
27Periorbital edema (HP:0100539)2.51429531
28Methylmalonic acidemia (HP:0002912)2.49625717
29Ankle clonus (HP:0011448)2.48639849
30Constricted visual fields (HP:0001133)2.48303842
31Torticollis (HP:0000473)2.47519307
32Epileptiform EEG discharges (HP:0011182)2.45551208
33Ulnar deviation of the wrist (HP:0003049)2.44272161
34Oligomenorrhea (HP:0000876)2.43879495
35Reduced subcutaneous adipose tissue (HP:0003758)2.41615111
36Facial edema (HP:0000282)2.40787037
372-3 toe syndactyly (HP:0004691)2.39900725
38Sleep apnea (HP:0010535)2.36139741
39Short tibia (HP:0005736)2.34115679
40Fibular aplasia (HP:0002990)2.30690839
41Round ear (HP:0100830)2.29967140
42Stenosis of the external auditory canal (HP:0000402)2.27377828
43Broad-based gait (HP:0002136)2.27023327
44Attenuation of retinal blood vessels (HP:0007843)2.23087853
45Nemaline bodies (HP:0003798)2.22568503
46Obstructive sleep apnea (HP:0002870)2.21171390
47Insulin-resistant diabetes mellitus (HP:0000831)2.18630961
48Abolished electroretinogram (ERG) (HP:0000550)2.17072689
49Absent phalangeal crease (HP:0006109)2.16102855
50Abnormality of the phalanges of the 2nd finger (HP:0009541)2.15299325
51Anxiety (HP:0000739)2.11839579
52Progressive microcephaly (HP:0000253)2.10365729
53Abnormality of midbrain morphology (HP:0002418)2.07336967
54Molar tooth sign on MRI (HP:0002419)2.07336967
55True hermaphroditism (HP:0010459)2.05821966
56Atonic seizures (HP:0010819)2.04563311
57Abnormality of homocysteine metabolism (HP:0010919)2.02111338
58Homocystinuria (HP:0002156)2.02111338
59Intellectual disability, moderate (HP:0002342)2.01708873
60Malignant neoplasm of the central nervous system (HP:0100836)2.01694381
61Aplasia/Hypoplasia of the tibia (HP:0005772)2.00460109
62Submucous cleft hard palate (HP:0000176)1.99715449
63Stomatitis (HP:0010280)1.99641217
64Cerebral hypomyelination (HP:0006808)1.98557829
65Abnormality of the lower motor neuron (HP:0002366)1.97693706
66Absent septum pellucidum (HP:0001331)1.93838664
67Abnormality of the middle phalanges of the toes (HP:0010183)1.93387488
68Exercise-induced myalgia (HP:0003738)1.92740163
69Urinary bladder sphincter dysfunction (HP:0002839)1.91845668
70Pendular nystagmus (HP:0012043)1.91548677
71Synostosis involving the elbow (HP:0003938)1.89693116
72Humeroradial synostosis (HP:0003041)1.89693116
73Mesomelia (HP:0003027)1.89498010
74Neuroectodermal neoplasm (HP:0030061)1.87905363
75Neuroepithelial neoplasm (HP:0030063)1.87905363
76Nervous tissue neoplasm (HP:0030060)1.87905363
77Bony spicule pigmentary retinopathy (HP:0007737)1.87579192
78Fatigue (HP:0012378)1.86018237
79Muscle fiber inclusion bodies (HP:0100299)1.85937121
80Supranuclear gaze palsy (HP:0000605)1.84347244
81Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.83498953
82Hyperglycemia (HP:0003074)1.83084233
83Hypoplasia of the uterus (HP:0000013)1.82954105
84Distal arthrogryposis (HP:0005684)1.82353277
85Nephronophthisis (HP:0000090)1.80049692
86Pancreatic fibrosis (HP:0100732)1.78647286
87Aplasia/hypoplasia of the uterus (HP:0008684)1.77689707
88Nonprogressive disorder (HP:0003680)1.77643580
89Severe visual impairment (HP:0001141)1.77519725
90Conjunctival hamartoma (HP:0100780)1.77380487
91Brittle hair (HP:0002299)1.74410828
92Maternal diabetes (HP:0009800)1.73472156
93Pancreatic cysts (HP:0001737)1.70467134
94Craniofacial dystonia (HP:0012179)1.69541984
953-Methylglutaconic aciduria (HP:0003535)1.69160469
96Midline defect of the nose (HP:0004122)1.68401335
97Chronic diarrhea (HP:0002028)1.67285894
98Delayed CNS myelination (HP:0002188)1.67281863
99Abnormality of the septum pellucidum (HP:0007375)1.66811825
100Type I diabetes mellitus (HP:0100651)1.64141464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG24.19486274
2PHKG14.19486274
3PAK63.29866222
4MARK13.22948571
5CASK2.87989332
6TESK22.86216067
7TESK12.69543486
8TAOK32.51821853
9FGFR22.34827589
10LIMK12.27221753
11DYRK21.89879378
12TXK1.89216671
13ADRBK21.83310497
14INSRR1.82622367
15CSNK1G21.74512923
16MOS1.70512829
17LMTK21.65071588
18NUAK11.60060825
19NTRK21.52798907
20PRKD31.48639851
21SIK31.45746772
22FRK1.40465252
23VRK21.32456523
24MUSK1.30402144
25SGK4941.28094053
26SGK2231.28094053
27CSNK1G31.26229411
28EPHA31.25645701
29TNIK1.25299067
30CSNK1G11.23615524
31TRIM281.23165103
32NTRK31.22872126
33NLK1.13883889
34MAPK131.13497679
35EIF2AK31.11203112
36MINK11.10838867
37DAPK21.09005029
38CDK91.07849373
39MAP3K121.06608712
40EPHB21.04723048
41SGK21.04273685
42CSNK1A1L1.02210528
43OBSCN1.01664895
44NEK90.99612016
45GRK70.91754062
46STK110.90509788
47AURKA0.89123710
48PRKCE0.88800849
49PLK20.86953214
50CAMKK10.86727016
51SGK30.85668925
52SCYL20.85361733
53MAP2K70.85013156
54FES0.80763183
55TSSK60.80615141
56TIE10.78053886
57CAMKK20.77508214
58TYRO30.72444875
59JAK30.71683210
60BMPR1B0.69449727
61RIPK10.63481778
62KDR0.62958466
63CCNB10.62459223
64PRKCG0.59723892
65KSR10.58042373
66RPS6KA20.56399600
67MST40.53150031
68PAK30.51980660
69DYRK1A0.51097990
70CDK50.50869541
71BCR0.50476047
72EIF2AK20.50370267
73NTRK10.50078961
74TAF10.49966710
75ADRBK10.47803417
76MAP3K40.46719951
77MAP2K20.44855605
78RPS6KA10.44432133
79CSNK1A10.43612991
80CAMK2D0.42758484
81RPS6KA30.42404023
82IRAK10.42252636
83SIK20.41896310
84BCKDK0.41295044
85FGR0.40237784
86CAMK2A0.39683967
87MAP2K10.39326674
88GRK10.36105396
89PRKG10.35743227
90MAPK80.35528106
91VRK10.35308937
92CAMK2G0.34642697
93MAP4K20.34282360
94DYRK1B0.34146999
95ROCK10.33213455
96EPHB10.32678753
97WNK40.32073741
98ERBB20.30609665
99SGK10.30452871
100RPS6KB10.29516976

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.79787786
2GABAergic synapse_Homo sapiens_hsa047272.76421130
3Morphine addiction_Homo sapiens_hsa050322.76012374
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.61504878
5Nicotine addiction_Homo sapiens_hsa050332.57157743
6Proteasome_Homo sapiens_hsa030502.49846321
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.29329548
8Dopaminergic synapse_Homo sapiens_hsa047282.15859983
9Phototransduction_Homo sapiens_hsa047442.11654720
10Nitrogen metabolism_Homo sapiens_hsa009102.10536174
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09065996
12Circadian rhythm_Homo sapiens_hsa047101.97753379
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.95669900
14Asthma_Homo sapiens_hsa053101.88449300
15Circadian entrainment_Homo sapiens_hsa047131.88405910
16Tight junction_Homo sapiens_hsa045301.86100215
17Collecting duct acid secretion_Homo sapiens_hsa049661.85800706
18Regulation of autophagy_Homo sapiens_hsa041401.77429539
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73758836
20Arginine biosynthesis_Homo sapiens_hsa002201.58423286
21Spliceosome_Homo sapiens_hsa030401.50492746
22Glutamatergic synapse_Homo sapiens_hsa047241.50147444
23Cholinergic synapse_Homo sapiens_hsa047251.48017678
24Hedgehog signaling pathway_Homo sapiens_hsa043401.45561920
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44103636
26Insulin secretion_Homo sapiens_hsa049111.43186507
27Oxidative phosphorylation_Homo sapiens_hsa001901.41413803
28Autoimmune thyroid disease_Homo sapiens_hsa053201.39334440
29Salivary secretion_Homo sapiens_hsa049701.36247242
30mRNA surveillance pathway_Homo sapiens_hsa030151.30720302
31Cocaine addiction_Homo sapiens_hsa050301.29864993
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28956310
33Serotonergic synapse_Homo sapiens_hsa047261.28859204
34Parkinsons disease_Homo sapiens_hsa050121.27032640
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26774580
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21040692
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15146011
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15137489
39One carbon pool by folate_Homo sapiens_hsa006701.11302487
40Allograft rejection_Homo sapiens_hsa053301.10788254
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10663649
42Gastric acid secretion_Homo sapiens_hsa049711.09460111
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09211084
44Taste transduction_Homo sapiens_hsa047421.07770148
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.06171246
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05524120
47Olfactory transduction_Homo sapiens_hsa047401.04759963
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04385744
49Sulfur metabolism_Homo sapiens_hsa009201.00010993
50Amphetamine addiction_Homo sapiens_hsa050310.99632404
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.97738918
52Renin secretion_Homo sapiens_hsa049240.96707646
53Alzheimers disease_Homo sapiens_hsa050100.95721226
54Vibrio cholerae infection_Homo sapiens_hsa051100.95621757
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88467052
56RNA transport_Homo sapiens_hsa030130.86879602
57Basal transcription factors_Homo sapiens_hsa030220.83294253
58Oocyte meiosis_Homo sapiens_hsa041140.80729563
59Oxytocin signaling pathway_Homo sapiens_hsa049210.80035158
60Huntingtons disease_Homo sapiens_hsa050160.78934134
61Chemical carcinogenesis_Homo sapiens_hsa052040.78294038
62Protein export_Homo sapiens_hsa030600.76503866
63RNA polymerase_Homo sapiens_hsa030200.75532723
64Cardiac muscle contraction_Homo sapiens_hsa042600.74926858
65Calcium signaling pathway_Homo sapiens_hsa040200.73604022
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70140515
67Primary immunodeficiency_Homo sapiens_hsa053400.69928950
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68405589
69Rheumatoid arthritis_Homo sapiens_hsa053230.68288225
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66866642
71Long-term depression_Homo sapiens_hsa047300.66529425
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65384892
73Vitamin digestion and absorption_Homo sapiens_hsa049770.64416129
74Alcoholism_Homo sapiens_hsa050340.63963931
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61412919
76cAMP signaling pathway_Homo sapiens_hsa040240.59745687
77Estrogen signaling pathway_Homo sapiens_hsa049150.59023003
78Peroxisome_Homo sapiens_hsa041460.56488980
79Glutathione metabolism_Homo sapiens_hsa004800.53922246
80Biosynthesis of amino acids_Homo sapiens_hsa012300.53406807
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51966910
82RNA degradation_Homo sapiens_hsa030180.51927530
83Wnt signaling pathway_Homo sapiens_hsa043100.51757120
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51599132
85Glucagon signaling pathway_Homo sapiens_hsa049220.50035197
86Thyroid hormone synthesis_Homo sapiens_hsa049180.46781684
87Retinol metabolism_Homo sapiens_hsa008300.46422564
88Ether lipid metabolism_Homo sapiens_hsa005650.45247422
89Carbon metabolism_Homo sapiens_hsa012000.45052096
90Butanoate metabolism_Homo sapiens_hsa006500.43378055
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40990161
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37776856
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.36766395
94Axon guidance_Homo sapiens_hsa043600.35386322
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35377275
96Hippo signaling pathway_Homo sapiens_hsa043900.34360123
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.34094408
98T cell receptor signaling pathway_Homo sapiens_hsa046600.32276446
99MAPK signaling pathway_Homo sapiens_hsa040100.31893674
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.31639763

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