ATP5C1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tooth mineralization (GO:0034505)9.84462318
2positive regulation of protein sumoylation (GO:0033235)8.62803113
3negative regulation of T-helper cell differentiation (GO:0045623)8.25211807
4negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)8.25211807
5protein K11-linked deubiquitination (GO:0035871)8.18888064
6seminiferous tubule development (GO:0072520)7.75241865
7regulation of T-helper 1 cell differentiation (GO:0045625)7.39310133
8detection of chemical stimulus involved in sensory perception (GO:0050907)7.19027371
9positive regulation of RNA splicing (GO:0033120)7.17051108
10regulation of T-helper 2 cell differentiation (GO:0045628)7.14869931
11negative regulation of type 2 immune response (GO:0002829)7.00228575
12negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)6.86955080
13activation of protein kinase A activity (GO:0034199)6.56082712
14positive regulation of mitochondrial fission (GO:0090141)6.27091212
15negative regulation of alpha-beta T cell differentiation (GO:0046639)6.20499699
16righting reflex (GO:0060013)5.85625498
17cAMP biosynthetic process (GO:0006171)5.74069508
18enteric nervous system development (GO:0048484)5.69699747
19synaptic transmission, dopaminergic (GO:0001963)5.60220975
20dendritic spine morphogenesis (GO:0060997)5.58902225
21regulation of protein sumoylation (GO:0033233)5.52132841
22icosanoid secretion (GO:0032309)5.40069191
23arachidonic acid secretion (GO:0050482)5.40069191
24positive regulation of T-helper 1 type immune response (GO:0002827)5.38295644
25detection of chemical stimulus (GO:0009593)5.18074735
26phosphatidylinositol acyl-chain remodeling (GO:0036149)5.11009973
27energy coupled proton transport, down electrochemical gradient (GO:0015985)4.78181493
28ATP synthesis coupled proton transport (GO:0015986)4.78181493
29regulation of mitochondrial fission (GO:0090140)4.67140595
30heterotypic cell-cell adhesion (GO:0034113)4.65235072
31positive regulation of T-helper cell differentiation (GO:0045624)4.60453511
32phosphatidylserine acyl-chain remodeling (GO:0036150)4.60232466
33exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.51114191
34cilium or flagellum-dependent cell motility (GO:0001539)4.46285238
35hepatocyte apoptotic process (GO:0097284)4.42309013
36fatty acid derivative transport (GO:1901571)4.35141036
37icosanoid transport (GO:0071715)4.35141036
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.32964531
39cellular response to ATP (GO:0071318)4.23887111
40neural tube formation (GO:0001841)4.19501874
41DNA deamination (GO:0045006)4.06754114
42drug transmembrane transport (GO:0006855)4.01169025
43phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.99014992
44negative regulation of cytosolic calcium ion concentration (GO:0051481)3.97076915
45ATP hydrolysis coupled proton transport (GO:0015991)3.93363235
46energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.93363235
47endothelial cell differentiation (GO:0045446)3.93197965
48negative regulation of alpha-beta T cell activation (GO:0046636)3.91914784
49regulation of T-helper 1 type immune response (GO:0002825)3.86278611
50attachment of spindle microtubules to kinetochore (GO:0008608)3.79502185
51embryonic digestive tract morphogenesis (GO:0048557)3.71553394
52positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.67406654
53chemosensory behavior (GO:0007635)3.61752574
54monoamine transport (GO:0015844)3.57810386
55retina layer formation (GO:0010842)3.51616061
56reflex (GO:0060004)3.46537509
57phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.46071840
58neuronal ion channel clustering (GO:0045161)3.45359417
59positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.42895547
60regulation of T-helper cell differentiation (GO:0045622)3.42386316
61nephron epithelium morphogenesis (GO:0072088)3.38609037
62nephron tubule morphogenesis (GO:0072078)3.38609037
63protein localization to synapse (GO:0035418)3.35623308
64positive regulation of membrane potential (GO:0045838)3.34467981
65cytidine deamination (GO:0009972)3.33816223
66cytidine metabolic process (GO:0046087)3.33816223
67cytidine catabolic process (GO:0006216)3.33816223
68negative regulation of T cell differentiation (GO:0045581)3.27528622
69vocalization behavior (GO:0071625)3.27152344
70water transport (GO:0006833)3.20633139
71regulation of cAMP-mediated signaling (GO:0043949)3.12009614
72detection of light stimulus involved in visual perception (GO:0050908)3.10341194
73detection of light stimulus involved in sensory perception (GO:0050962)3.10341194
74chaperone-mediated protein transport (GO:0072321)3.09962818
75phosphatidylcholine acyl-chain remodeling (GO:0036151)3.01429357
76cyclic purine nucleotide metabolic process (GO:0052652)2.97856149
77negative regulation of astrocyte differentiation (GO:0048712)2.97458800
78neuromuscular process controlling posture (GO:0050884)2.96371331
79left/right axis specification (GO:0070986)2.95405668
80regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.94390071
81regulation of type 2 immune response (GO:0002828)2.94144807
82fluid transport (GO:0042044)2.93347391
83cyclic nucleotide biosynthetic process (GO:0009190)2.90767146
84positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.88336130
85response to dietary excess (GO:0002021)2.85751353
86regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.85061895
87negative regulation of actin filament bundle assembly (GO:0032232)2.85015179
88single fertilization (GO:0007338)2.81254417
89response to nicotine (GO:0035094)2.71550991
90cAMP metabolic process (GO:0046058)2.70498209
91adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)2.69627402
92potassium ion transmembrane transport (GO:0071805)2.67943780
93cellular potassium ion transport (GO:0071804)2.67943780
94cellular response to glucagon stimulus (GO:0071377)2.67909522
95positive thymic T cell selection (GO:0045059)2.67499428
96dendritic spine organization (GO:0097061)2.66661925
97mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.64889706
98pyrimidine ribonucleoside catabolic process (GO:0046133)2.64847726
99regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.62735116
100detection of chemical stimulus involved in sensory perception of smell (GO:0050911)11.2865227

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse8.91766292
2VDR_22108803_ChIP-Seq_LS180_Human5.38376834
3IGF1R_20145208_ChIP-Seq_DFB_Human4.48652792
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.08467886
5AR_21572438_ChIP-Seq_LNCaP_Human3.38521453
6ZNF274_21170338_ChIP-Seq_K562_Hela2.60082417
7EZH2_22144423_ChIP-Seq_EOC_Human2.50333298
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29575357
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28666982
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08798122
11PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.05178501
12GBX2_23144817_ChIP-Seq_PC3_Human1.92727912
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.83423174
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78756634
15ER_23166858_ChIP-Seq_MCF-7_Human1.78436703
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73067238
17SMAD3_21741376_ChIP-Seq_EPCs_Human1.69009526
18TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67996006
19POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.67996006
20RNF2_27304074_Chip-Seq_NSC_Mouse1.61306864
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60339376
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58449779
23SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57283897
24YY1_22570637_ChIP-Seq_MALME-3M_Human1.55806740
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49237225
26FUS_26573619_Chip-Seq_HEK293_Human1.47342073
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43904843
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41785287
29CBP_20019798_ChIP-Seq_JUKART_Human1.40953583
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40953583
31EWS_26573619_Chip-Seq_HEK293_Human1.40456260
32NANOG_18555785_Chip-Seq_ESCs_Mouse1.40426591
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.40023809
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35270055
35P300_19829295_ChIP-Seq_ESCs_Human1.34528465
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.31969755
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31454938
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.31225729
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.30016325
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29224492
41BCAT_22108803_ChIP-Seq_LS180_Human1.28854614
42ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28578573
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28154482
44GATA6_21074721_ChIP-Seq_CACO-2_Human1.27840021
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27196345
46PHF8_20622853_ChIP-Seq_HELA_Human1.25288541
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25046352
48TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.24592713
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.24406190
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24406190
51TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.23503506
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.23315797
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23157801
54PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22801100
55HNFA_21074721_ChIP-Seq_CACO-2_Human1.20784474
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.19991839
57TCF4_22108803_ChIP-Seq_LS180_Human1.18804932
58TP53_16413492_ChIP-PET_HCT116_Human1.18724126
59TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18572270
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18503311
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18067141
62PRDM14_20953172_ChIP-Seq_ESCs_Human1.17151649
63SMAD4_21799915_ChIP-Seq_A2780_Human1.16979088
64STAT3_23295773_ChIP-Seq_U87_Human1.16335882
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15872881
66TAF15_26573619_Chip-Seq_HEK293_Human1.15651716
67PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.15175546
68SOX2_19829295_ChIP-Seq_ESCs_Human1.14628809
69NANOG_19829295_ChIP-Seq_ESCs_Human1.14628809
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14354045
71SOX2_18555785_Chip-Seq_ESCs_Mouse1.14185372
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13252246
73SMAD4_21741376_ChIP-Seq_EPCs_Human1.12891716
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12791895
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.12537785
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.12532761
77EGR1_19032775_ChIP-ChIP_M12_Human1.12425024
78CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.12045909
79ETV1_20927104_ChIP-Seq_GIST48_Human1.11778199
80SMAD3_21741376_ChIP-Seq_HESCs_Human1.10368701
81NANOG_20526341_ChIP-Seq_ESCs_Human1.09274391
82P53_22387025_ChIP-Seq_ESCs_Mouse1.07931174
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07431714
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.06247831
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04837393
86AR_25329375_ChIP-Seq_VCAP_Human1.04514263
87GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03928076
88JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02459415
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01241474
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.00824063
91TBL1_22424771_ChIP-Seq_293T_Human1.00804068
92NCOR_22424771_ChIP-Seq_293T_Human0.99942823
93STAT3_18555785_Chip-Seq_ESCs_Mouse0.99800125
94PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99134932
95KLF4_18555785_Chip-Seq_ESCs_Mouse0.99087331
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98912989
97JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98223128
98RBPJ_21746931_ChIP-Seq_IB4_Human0.97691261
99NFYB_21822215_ChIP-Seq_K562_Human0.95675568
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94119113

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005084_abnormal_gallbladder_morpholo9.89452630
2MP0008961_abnormal_basal_metabolism7.17647910
3MP0006072_abnormal_retinal_apoptosis3.05175001
4MP0004130_abnormal_muscle_cell2.85569105
5MP0003252_abnormal_bile_duct2.78663388
6MP0004133_heterotaxia2.48250762
7MP0005646_abnormal_pituitary_gland2.15736919
8MP0002928_abnormal_bile_duct2.11793007
9MP0002751_abnormal_autonomic_nervous2.09865991
10MP0003880_abnormal_central_pattern2.08363274
11MP0005379_endocrine/exocrine_gland_phen2.02418628
12MP0004264_abnormal_extraembryonic_tissu1.97405125
13MP0002102_abnormal_ear_morphology1.81343508
14MP0005448_abnormal_energy_balance1.79770455
15MP0005671_abnormal_response_to1.78653710
16MP0001968_abnormal_touch/_nociception1.77929908
17MP0002837_dystrophic_cardiac_calcinosis1.69029597
18MP0002736_abnormal_nociception_after1.59395889
19MP0003943_abnormal_hepatobiliary_system1.47816981
20MP0003195_calcinosis1.46371062
21MP0003718_maternal_effect1.38779743
22MP0005253_abnormal_eye_physiology1.35154564
23MP0009764_decreased_sensitivity_to1.32874373
24MP0001835_abnormal_antigen_presentation1.32740489
25MP0005220_abnormal_exocrine_pancreas1.32486019
26MP0008875_abnormal_xenobiotic_pharmacok1.31608563
27MP0005551_abnormal_eye_electrophysiolog1.29879029
28MP0001905_abnormal_dopamine_level1.29414175
29MP0001270_distended_abdomen1.23042928
30MP0004147_increased_porphyrin_level1.21965171
31MP0008872_abnormal_physiological_respon1.20027049
32MP0001800_abnormal_humoral_immune1.19721006
33MP0002909_abnormal_adrenal_gland1.17610489
34MP0002572_abnormal_emotion/affect_behav1.10727411
35MP0005408_hypopigmentation1.10275202
36MP0001529_abnormal_vocalization1.07728240
37MP0006276_abnormal_autonomic_nervous1.06701617
38MP0000372_irregular_coat_pigmentation1.05006530
39MP0002693_abnormal_pancreas_physiology1.04680204
40MP0002277_abnormal_respiratory_mucosa1.01909002
41MP0002405_respiratory_system_inflammati0.99460418
42MP0003866_abnormal_defecation0.95657385
43MP0003646_muscle_fatigue0.95135491
44MP0005423_abnormal_somatic_nervous0.94978654
45MP0000465_gastrointestinal_hemorrhage0.94526626
46MP0002138_abnormal_hepatobiliary_system0.93508321
47MP0009785_altered_susceptibility_to0.90607627
48MP0008877_abnormal_DNA_methylation0.90505712
49MP0000470_abnormal_stomach_morphology0.90079454
50MP0004145_abnormal_muscle_electrophysio0.89877033
51MP0001944_abnormal_pancreas_morphology0.87716527
52MP0002163_abnormal_gland_morphology0.87122911
53MP0009046_muscle_twitch0.86821799
54MP0001790_abnormal_immune_system0.85372400
55MP0005387_immune_system_phenotype0.85372400
56MP0005000_abnormal_immune_tolerance0.85171097
57MP0001486_abnormal_startle_reflex0.84956031
58MP0002148_abnormal_hypersensitivity_rea0.84783515
59MP0001986_abnormal_taste_sensitivity0.83806124
60MP0008469_abnormal_protein_level0.81745309
61MP0002234_abnormal_pharynx_morphology0.80985783
62MP0001485_abnormal_pinna_reflex0.80874669
63MP0002723_abnormal_immune_serum0.79591593
64MP0005360_urolithiasis0.79417554
65MP0005332_abnormal_amino_acid0.79060283
66MP0009745_abnormal_behavioral_response0.77524988
67MP0006292_abnormal_olfactory_placode0.76715788
68MP0003638_abnormal_response/metabolism_0.75416414
69MP0002136_abnormal_kidney_physiology0.74855309
70MP0001845_abnormal_inflammatory_respons0.74776929
71MP0001501_abnormal_sleep_pattern0.73326218
72MP0004019_abnormal_vitamin_homeostasis0.73197739
73MP0005377_hearing/vestibular/ear_phenot0.72560546
74MP0003878_abnormal_ear_physiology0.72560546
75MP0000604_amyloidosis0.72030083
76MP0002420_abnormal_adaptive_immunity0.71952913
77MP0002452_abnormal_antigen_presenting0.71604173
78MP0001819_abnormal_immune_cell0.71132592
79MP0000703_abnormal_thymus_morphology0.70206608
80MP0004742_abnormal_vestibular_system0.70117241
81MP0003786_premature_aging0.69275903
82MP0009333_abnormal_splenocyte_physiolog0.69195859
83MP0002272_abnormal_nervous_system0.69043601
84MP0005410_abnormal_fertilization0.66405687
85MP0002822_catalepsy0.65737179
86MP0003763_abnormal_thymus_physiology0.63750172
87MP0005165_increased_susceptibility_to0.63341382
88MP0002735_abnormal_chemical_nociception0.62715470
89MP0005645_abnormal_hypothalamus_physiol0.60371668
90MP0002098_abnormal_vibrissa_morphology0.59239880
91MP0003953_abnormal_hormone_level0.58322745
92MP0000716_abnormal_immune_system0.57105535
93MP0002398_abnormal_bone_marrow0.56783475
94MP0003724_increased_susceptibility_to0.56562842
95MP0002733_abnormal_thermal_nociception0.55806051
96MP0001970_abnormal_pain_threshold0.55697550
97MP0003137_abnormal_impulse_conducting0.55174132
98MP0002078_abnormal_glucose_homeostasis0.55142239
99MP0003635_abnormal_synaptic_transmissio0.54890160
100MP0001919_abnormal_reproductive_system0.54879040

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)7.37431753
2Overgrowth (HP:0001548)6.33989572
3Abnormality of renal resorption (HP:0011038)6.22782949
4Abnormality of dental color (HP:0011073)5.73489232
5Polyuria (HP:0000103)5.72037244
6Abnormality of calcium-phosphate metabolism (HP:0100530)5.70476674
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.00497430
8Abnormal urine output (HP:0012590)4.82433330
9Osteomalacia (HP:0002749)4.79149893
10Abnormality of renal excretion (HP:0011036)4.29370978
11Abnormality of the dental pulp (HP:0006479)3.99413299
12Abnormality of midbrain morphology (HP:0002418)3.73289544
13Molar tooth sign on MRI (HP:0002419)3.73289544
14Chronic bronchitis (HP:0004469)3.38866185
15Nephronophthisis (HP:0000090)3.38184491
16Inability to walk (HP:0002540)3.35619154
17Volvulus (HP:0002580)3.28580724
18IgM deficiency (HP:0002850)3.27684566
19Abnormality of urine glucose concentration (HP:0011016)3.16358382
20Glycosuria (HP:0003076)3.16358382
21Abnormal respiratory motile cilium physiology (HP:0012261)3.14225572
22Hyperphosphaturia (HP:0003109)3.02211589
23Absent rod-and cone-mediated responses on ERG (HP:0007688)2.88993986
24Round ear (HP:0100830)2.86777749
25Abnormality of the renal medulla (HP:0100957)2.80271271
26Congenital stationary night blindness (HP:0007642)2.75500259
27Rhinitis (HP:0012384)2.72949601
28Tachypnea (HP:0002789)2.68165844
29Abnormal rod and cone electroretinograms (HP:0008323)2.62141192
30Autoimmune thrombocytopenia (HP:0001973)2.61110627
31Panhypogammaglobulinemia (HP:0003139)2.53379988
32Degeneration of anterior horn cells (HP:0002398)2.49814910
33Abnormality of the anterior horn cell (HP:0006802)2.49814910
34Aplastic anemia (HP:0001915)2.48915896
35Abnormal urine phosphate concentration (HP:0012599)2.44244842
36Toxemia of pregnancy (HP:0100603)2.40207596
37True hermaphroditism (HP:0010459)2.32027811
38Mitochondrial inheritance (HP:0001427)2.24917153
39Prominent supraorbital ridges (HP:0000336)2.17669106
40Acute necrotizing encephalopathy (HP:0006965)2.17647319
41Abolished electroretinogram (ERG) (HP:0000550)2.14686678
42Nephrocalcinosis (HP:0000121)2.14675767
43Increased CSF lactate (HP:0002490)2.13769259
44Drooling (HP:0002307)2.13005475
45Hypoproteinemia (HP:0003075)2.11712653
46Pancreatic fibrosis (HP:0100732)2.10190605
47Type II lissencephaly (HP:0007260)2.07489487
48Decreased central vision (HP:0007663)2.03436201
49Congenital, generalized hypertrichosis (HP:0004540)2.01206657
50Progressive macrocephaly (HP:0004481)2.00308340
51Excessive salivation (HP:0003781)1.99104020
52Renal Fanconi syndrome (HP:0001994)1.97256369
53Hepatocellular necrosis (HP:0001404)1.95782564
54Pancreatic cysts (HP:0001737)1.94888717
55Polydipsia (HP:0001959)1.94692506
56Abnormal drinking behavior (HP:0030082)1.94692506
57Absent/shortened dynein arms (HP:0200106)1.93420676
58Dynein arm defect of respiratory motile cilia (HP:0012255)1.93420676
59Stomatitis (HP:0010280)1.91876639
60Acute encephalopathy (HP:0006846)1.88653448
61Attenuation of retinal blood vessels (HP:0007843)1.88502634
62Gaze-evoked nystagmus (HP:0000640)1.87028653
63Poor speech (HP:0002465)1.85252189
64Hepatic necrosis (HP:0002605)1.83623526
65Abnormal delayed hypersensitivity skin test (HP:0002963)1.82933648
66Severe muscular hypotonia (HP:0006829)1.81953101
67Increased hepatocellular lipid droplets (HP:0006565)1.80951075
68Anhidrosis (HP:0000970)1.78250086
69Renal tubular dysfunction (HP:0000124)1.78134104
70Renal cortical cysts (HP:0000803)1.77033279
71Generalized aminoaciduria (HP:0002909)1.76857883
72Abnormal mitochondria in muscle tissue (HP:0008316)1.75088416
73Small hand (HP:0200055)1.73897930
74IgG deficiency (HP:0004315)1.72342768
75Pendular nystagmus (HP:0012043)1.70602413
76B lymphocytopenia (HP:0010976)1.69710959
77Petechiae (HP:0000967)1.68851725
78Lip pit (HP:0100267)1.68069078
79Abnormality of the prostate (HP:0008775)1.65980050
80Bony spicule pigmentary retinopathy (HP:0007737)1.64068124
81Abnormality of the renal cortex (HP:0011035)1.63780107
82Abnormality of B cell number (HP:0010975)1.62261773
83Nephropathy (HP:0000112)1.61264115
84Medial flaring of the eyebrow (HP:0010747)1.60956152
85Constricted visual fields (HP:0001133)1.60555570
86Bronchitis (HP:0012387)1.59959407
87Depressed nasal tip (HP:0000437)1.59310858
88Pancytopenia (HP:0001876)1.55278514
89Thyroiditis (HP:0100646)1.55023460
90Hypomagnesemia (HP:0002917)1.54872793
91Cerebral edema (HP:0002181)1.51988972
92Agammaglobulinemia (HP:0004432)1.51276132
93Lipid accumulation in hepatocytes (HP:0006561)1.51189456
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.50437858
95Amniotic constriction ring (HP:0009775)1.49799358
96Abnormality of placental membranes (HP:0011409)1.49799358
97Thick eyebrow (HP:0000574)1.49751111
98Lipoatrophy (HP:0100578)1.49549066
99Abnormal ciliary motility (HP:0012262)1.49363334
100Abnormal respiratory epithelium morphology (HP:0012253)1.49042534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK29.34799737
2MAP4K14.33739277
3STK33.27844423
4BLK2.45298282
5TXK2.42026466
6TNIK2.25163749
7FRK2.11273825
8RIPK42.08761959
9ZAK1.89874530
10MAP4K21.78405040
11BMPR21.72750232
12PLK41.66672832
13KDR1.64285964
14NUAK11.59846291
15ADRBK21.55632435
16GRK11.48266424
17PINK11.37947950
18VRK11.28379311
19INSRR1.27601188
20EIF2AK31.25724810
21VRK21.22742588
22TIE11.14524494
23WNK31.11496497
24MAP3K121.08476894
25TLK11.03286741
26PLK21.01182364
27MATK0.99945315
28STK390.99737271
29OXSR10.99265328
30TESK20.95438451
31MST40.93549619
32STK160.93164407
33BUB10.89888366
34TAOK30.89218504
35PRKCQ0.88223482
36BMPR1B0.88059809
37WNK40.86386625
38SYK0.86238109
39TEC0.81707707
40CDK80.79260761
41PLK30.76450684
42BCR0.76067667
43ERBB30.73801897
44MYLK0.73262768
45DAPK10.71969327
46MUSK0.69767623
47OBSCN0.68529251
48ACVR1B0.65825369
49TRIM280.64369099
50PLK10.63047705
51MAPK130.59667854
52ITK0.59235106
53STK240.58007061
54PIK3CG0.57776260
55KIT0.57572939
56FGFR10.56201354
57SRPK10.56193295
58PRKCE0.55800723
59IKBKB0.54482218
60NEK10.52964803
61PRKCG0.51573245
62PRKACA0.50738506
63BCKDK0.50514314
64STK38L0.49928100
65ROCK10.49645204
66CSNK1G30.49463599
67PHKG20.48052627
68PHKG10.48052627
69ADRBK10.47959658
70GRK50.47424667
71ABL10.47230623
72LCK0.47037143
73PAK30.46387455
74EIF2AK10.45137841
75HIPK20.44692020
76CAMK2A0.44562621
77CHUK0.44388869
78MAP3K40.44083591
79PRKACG0.43511758
80CDC42BPA0.42997283
81PRKCA0.42260704
82LYN0.41742867
83GRK60.38278283
84ROCK20.38061220
85CSNK1G20.37867167
86CSNK1G10.37692333
87SRC0.35761421
88SCYL20.35570643
89FLT30.35338980
90PRKG10.34703678
91DAPK20.34682537
92NLK0.33765467
93TAF10.31982791
94IGF1R0.31549500
95MINK10.31337271
96GRK70.30225923
97DAPK30.30167961
98IKBKE0.30089866
99CDK190.29865899
100PRKCB0.28964625

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.65576042
2Sulfur metabolism_Homo sapiens_hsa009203.31513808
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.02225006
4Linoleic acid metabolism_Homo sapiens_hsa005912.97808237
5Sulfur relay system_Homo sapiens_hsa041222.74297720
6Oxidative phosphorylation_Homo sapiens_hsa001902.43742678
7Ovarian steroidogenesis_Homo sapiens_hsa049132.37120718
8Parkinsons disease_Homo sapiens_hsa050122.24270461
9Collecting duct acid secretion_Homo sapiens_hsa049662.16408202
10Proteasome_Homo sapiens_hsa030502.03522567
11Salivary secretion_Homo sapiens_hsa049701.97353551
12Asthma_Homo sapiens_hsa053101.96180183
13Taste transduction_Homo sapiens_hsa047421.77236659
14Type I diabetes mellitus_Homo sapiens_hsa049401.73424317
15Fat digestion and absorption_Homo sapiens_hsa049751.72795679
16Circadian entrainment_Homo sapiens_hsa047131.70081562
17Allograft rejection_Homo sapiens_hsa053301.68377658
18Autoimmune thyroid disease_Homo sapiens_hsa053201.67066999
19Pancreatic secretion_Homo sapiens_hsa049721.67019011
20Primary immunodeficiency_Homo sapiens_hsa053401.59745782
21Graft-versus-host disease_Homo sapiens_hsa053321.56855375
22Gastric acid secretion_Homo sapiens_hsa049711.54277851
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.50187301
24Glutamatergic synapse_Homo sapiens_hsa047241.46485705
25Thyroid hormone synthesis_Homo sapiens_hsa049181.45935287
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.43988418
27Insulin secretion_Homo sapiens_hsa049111.42308427
28Arachidonic acid metabolism_Homo sapiens_hsa005901.41759391
29Ether lipid metabolism_Homo sapiens_hsa005651.40614750
30Morphine addiction_Homo sapiens_hsa050321.37166890
31Rheumatoid arthritis_Homo sapiens_hsa053231.36629922
32Vibrio cholerae infection_Homo sapiens_hsa051101.31913783
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.31674049
34Synaptic vesicle cycle_Homo sapiens_hsa047211.31230901
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.31086344
36Amphetamine addiction_Homo sapiens_hsa050311.30821178
37RNA degradation_Homo sapiens_hsa030181.29465051
38Bile secretion_Homo sapiens_hsa049761.29453642
39GABAergic synapse_Homo sapiens_hsa047271.26403530
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23127015
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18256872
42Cocaine addiction_Homo sapiens_hsa050301.14245853
43Alzheimers disease_Homo sapiens_hsa050101.13636032
44Huntingtons disease_Homo sapiens_hsa050161.07722765
45Protein export_Homo sapiens_hsa030601.05467313
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03553093
47Nicotine addiction_Homo sapiens_hsa050330.92594158
48Caffeine metabolism_Homo sapiens_hsa002320.88354420
49Dilated cardiomyopathy_Homo sapiens_hsa054140.86166260
50Phototransduction_Homo sapiens_hsa047440.84757620
51RNA polymerase_Homo sapiens_hsa030200.83952799
52Calcium signaling pathway_Homo sapiens_hsa040200.82880412
53Serotonergic synapse_Homo sapiens_hsa047260.81157279
54Oxytocin signaling pathway_Homo sapiens_hsa049210.79719051
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79257746
56Antigen processing and presentation_Homo sapiens_hsa046120.78470836
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.77758188
58Pyruvate metabolism_Homo sapiens_hsa006200.73803728
59Nitrogen metabolism_Homo sapiens_hsa009100.68332006
60Purine metabolism_Homo sapiens_hsa002300.67650168
61Oocyte meiosis_Homo sapiens_hsa041140.66506288
62Platelet activation_Homo sapiens_hsa046110.64848229
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63518488
64Cardiac muscle contraction_Homo sapiens_hsa042600.63374860
65Cholinergic synapse_Homo sapiens_hsa047250.62621631
66Chemical carcinogenesis_Homo sapiens_hsa052040.60558491
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58218594
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57860437
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56743836
70Basal transcription factors_Homo sapiens_hsa030220.56569639
71Hematopoietic cell lineage_Homo sapiens_hsa046400.56442365
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54016678
73Melanogenesis_Homo sapiens_hsa049160.53903424
74Homologous recombination_Homo sapiens_hsa034400.52993157
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52782302
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51596432
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50903660
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50308916
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.48877025
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48283354
81Retinol metabolism_Homo sapiens_hsa008300.47266848
82Fanconi anemia pathway_Homo sapiens_hsa034600.46444637
83Staphylococcus aureus infection_Homo sapiens_hsa051500.46026636
84Gap junction_Homo sapiens_hsa045400.44878813
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.44756041
86Systemic lupus erythematosus_Homo sapiens_hsa053220.44012154
87Dopaminergic synapse_Homo sapiens_hsa047280.41396606
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40340529
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39601228
90Tryptophan metabolism_Homo sapiens_hsa003800.39345138
91Dorso-ventral axis formation_Homo sapiens_hsa043200.36173969
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34397490
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33702897
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.32907815
95Butanoate metabolism_Homo sapiens_hsa006500.31545377
96Chemokine signaling pathway_Homo sapiens_hsa040620.27414881
97African trypanosomiasis_Homo sapiens_hsa051430.26854960
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25727958
99Circadian rhythm_Homo sapiens_hsa047100.24498234
100GnRH signaling pathway_Homo sapiens_hsa049120.24374245

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