Rank | Gene Set | Z-score |
---|---|---|
1 | * mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.54535605 |
2 | * energy coupled proton transport, down electrochemical gradient (GO:0015985) | 6.18579416 |
3 | * ATP synthesis coupled proton transport (GO:0015986) | 6.18579416 |
4 | tricarboxylic acid cycle (GO:0006099) | 5.89699541 |
5 | * respiratory electron transport chain (GO:0022904) | 5.77292196 |
6 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 5.63421534 |
7 | * electron transport chain (GO:0022900) | 5.62853863 |
8 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.53569312 |
9 | * oxidative phosphorylation (GO:0006119) | 5.31188478 |
10 | sarcomere organization (GO:0045214) | 5.20220954 |
11 | NADH metabolic process (GO:0006734) | 4.90621888 |
12 | lysine metabolic process (GO:0006553) | 4.41751729 |
13 | lysine catabolic process (GO:0006554) | 4.41751729 |
14 | GTP biosynthetic process (GO:0006183) | 4.40218165 |
15 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.27201737 |
16 | NADH dehydrogenase complex assembly (GO:0010257) | 4.27201737 |
17 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.27201737 |
18 | cellular protein complex disassembly (GO:0043624) | 4.24053513 |
19 | actin-myosin filament sliding (GO:0033275) | 4.09784472 |
20 | muscle filament sliding (GO:0030049) | 4.09784472 |
21 | 2-oxoglutarate metabolic process (GO:0006103) | 4.07721423 |
22 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.02584858 |
23 | cardiac myofibril assembly (GO:0055003) | 4.00767363 |
24 | oxaloacetate metabolic process (GO:0006107) | 3.98788313 |
25 | maturation of SSU-rRNA (GO:0030490) | 3.98182602 |
26 | UTP biosynthetic process (GO:0006228) | 3.97808217 |
27 | * ATP biosynthetic process (GO:0006754) | 3.96257844 |
28 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.91698681 |
29 | creatine metabolic process (GO:0006600) | 3.84904615 |
30 | viral transcription (GO:0019083) | 3.81791089 |
31 | metallo-sulfur cluster assembly (GO:0031163) | 3.78786355 |
32 | iron-sulfur cluster assembly (GO:0016226) | 3.78786355 |
33 | UTP metabolic process (GO:0046051) | 3.77336014 |
34 | tricarboxylic acid metabolic process (GO:0072350) | 3.76355972 |
35 | aspartate family amino acid catabolic process (GO:0009068) | 3.76194229 |
36 | carnitine shuttle (GO:0006853) | 3.72707477 |
37 | fatty acid beta-oxidation (GO:0006635) | 3.72410143 |
38 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.70034417 |
39 | translational initiation (GO:0006413) | 3.66971141 |
40 | protein complex disassembly (GO:0043241) | 3.64807274 |
41 | translational termination (GO:0006415) | 3.62369574 |
42 | succinate metabolic process (GO:0006105) | 3.60901813 |
43 | cellular ketone body metabolic process (GO:0046950) | 3.58341872 |
44 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 3.56564037 |
45 | cardiac muscle contraction (GO:0060048) | 3.56437187 |
46 | ribosomal small subunit assembly (GO:0000028) | 3.55274020 |
47 | galactose catabolic process (GO:0019388) | 3.54493384 |
48 | glyoxylate metabolic process (GO:0046487) | 3.53937555 |
49 | ubiquinone metabolic process (GO:0006743) | 3.50818253 |
50 | positive regulation of prostaglandin secretion (GO:0032308) | 3.50544774 |
51 | GDP-mannose metabolic process (GO:0019673) | 3.49883688 |
52 | myofibril assembly (GO:0030239) | 3.49526274 |
53 | chaperone-mediated protein transport (GO:0072321) | 3.47840538 |
54 | translational elongation (GO:0006414) | 3.47082831 |
55 | DNA deamination (GO:0045006) | 3.46289884 |
56 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.44344588 |
57 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.40885174 |
58 | quinone biosynthetic process (GO:1901663) | 3.40721433 |
59 | ubiquinone biosynthetic process (GO:0006744) | 3.40721433 |
60 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 3.39625397 |
61 | heart contraction (GO:0060047) | 3.39349562 |
62 | heart process (GO:0003015) | 3.39349562 |
63 | macromolecular complex disassembly (GO:0032984) | 3.36030586 |
64 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 3.35766667 |
65 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.33049274 |
66 | * purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.32902740 |
67 | * purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.32810374 |
68 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 3.32484563 |
69 | fatty acid transmembrane transport (GO:1902001) | 3.31293516 |
70 | CTP metabolic process (GO:0046036) | 3.31176073 |
71 | CTP biosynthetic process (GO:0006241) | 3.31176073 |
72 | translation (GO:0006412) | 3.30914306 |
73 | base-excision repair, AP site formation (GO:0006285) | 3.30227202 |
74 | cardiac muscle cell development (GO:0055013) | 3.28085017 |
75 | branched-chain amino acid catabolic process (GO:0009083) | 3.26443058 |
76 | aerobic respiration (GO:0009060) | 3.22395869 |
77 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.21551034 |
78 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 3.20672315 |
79 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 3.19940074 |
80 | fatty acid catabolic process (GO:0009062) | 3.19915481 |
81 | deoxyribonucleotide catabolic process (GO:0009264) | 3.18255262 |
82 | ventricular cardiac muscle cell action potential (GO:0086005) | 3.18190005 |
83 | * nucleoside triphosphate biosynthetic process (GO:0009142) | 3.18029137 |
84 | protein neddylation (GO:0045116) | 3.17130484 |
85 | protein targeting to membrane (GO:0006612) | 3.16347551 |
86 | fatty acid oxidation (GO:0019395) | 3.15547271 |
87 | actin-mediated cell contraction (GO:0070252) | 3.15270671 |
88 | * purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 3.14983690 |
89 | * purine nucleoside monophosphate biosynthetic process (GO:0009127) | 3.14983690 |
90 | protein targeting to mitochondrion (GO:0006626) | 3.13485641 |
91 | regulation of mitochondrial translation (GO:0070129) | 3.11958650 |
92 | cardiac muscle tissue morphogenesis (GO:0055008) | 3.11921422 |
93 | cytidine deamination (GO:0009972) | 3.11903461 |
94 | cytidine metabolic process (GO:0046087) | 3.11903461 |
95 | cytidine catabolic process (GO:0006216) | 3.11903461 |
96 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.10350402 |
97 | * ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.10338962 |
98 | heme biosynthetic process (GO:0006783) | 3.09088166 |
99 | inner mitochondrial membrane organization (GO:0007007) | 3.08825941 |
100 | ketone body metabolic process (GO:1902224) | 3.08430404 |
101 | lipid oxidation (GO:0034440) | 3.08115604 |
102 | branched-chain amino acid metabolic process (GO:0009081) | 3.08007522 |
103 | peptidyl-histidine modification (GO:0018202) | 3.07483903 |
104 | protein targeting to ER (GO:0045047) | 3.07455236 |
105 | regulation of fatty acid oxidation (GO:0046320) | 3.06900595 |
106 | establishment of protein localization to mitochondrion (GO:0072655) | 3.06612023 |
107 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 3.06604560 |
108 | ribosomal small subunit biogenesis (GO:0042274) | 3.06374266 |
109 | short-chain fatty acid metabolic process (GO:0046459) | 3.06001671 |
110 | cytochrome complex assembly (GO:0017004) | 3.05771447 |
111 | regulation of cellular respiration (GO:0043457) | 3.05702787 |
112 | valine metabolic process (GO:0006573) | 3.05475453 |
113 | nucleotide salvage (GO:0043173) | 3.04396597 |
114 | regulation of cofactor metabolic process (GO:0051193) | 3.03609408 |
115 | regulation of coenzyme metabolic process (GO:0051196) | 3.03609408 |
116 | cardiac cell development (GO:0055006) | 3.03242613 |
117 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 3.02239966 |
118 | heart trabecula formation (GO:0060347) | 3.02051376 |
119 | carnitine metabolic process (GO:0009437) | 3.00830678 |
120 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.00225744 |
121 | * hydrogen ion transmembrane transport (GO:1902600) | 2.99761952 |
122 | acetyl-CoA metabolic process (GO:0006084) | 2.99485018 |
123 | cotranslational protein targeting to membrane (GO:0006613) | 2.99330882 |
124 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 2.99036352 |
125 | nucleoside diphosphate biosynthetic process (GO:0009133) | 2.97894886 |
126 | cellular component biogenesis (GO:0044085) | 2.97309159 |
127 | purine deoxyribonucleotide catabolic process (GO:0009155) | 2.97218903 |
128 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 2.96882174 |
129 | pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208) | 2.96319971 |
130 | carnitine transport (GO:0015879) | 2.96253871 |
131 | amino-acid betaine transport (GO:0015838) | 2.96253871 |
132 | purine nucleotide salvage (GO:0032261) | 2.94043182 |
133 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.93245214 |
134 | actomyosin structure organization (GO:0031032) | 2.92769640 |
135 | regulation of skeletal muscle contraction (GO:0014819) | 2.92555245 |
136 | protein localization to endoplasmic reticulum (GO:0070972) | 2.92450973 |
137 | protein complex biogenesis (GO:0070271) | 2.92039179 |
138 | viral life cycle (GO:0019058) | 2.91094160 |
139 | negative regulation of B cell apoptotic process (GO:0002903) | 2.90744877 |
140 | carnitine transmembrane transport (GO:1902603) | 2.90570878 |
141 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.90304363 |
142 | regulation of oxidative phosphorylation (GO:0002082) | 2.88988838 |
143 | gluconeogenesis (GO:0006094) | 2.88947755 |
144 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 2.88928718 |
145 | L-phenylalanine metabolic process (GO:0006558) | 2.88928718 |
146 | pseudouridine synthesis (GO:0001522) | 2.87285339 |
147 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.86949676 |
148 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.86949676 |
149 | * proton transport (GO:0015992) | 2.86041149 |
150 | regulation of actin filament-based movement (GO:1903115) | 2.85622256 |
151 | * mitochondrial transport (GO:0006839) | 2.85352758 |
152 | sulfur amino acid catabolic process (GO:0000098) | 2.84879635 |
153 | deoxyribose phosphate catabolic process (GO:0046386) | 2.82870170 |
154 | * hydrogen transport (GO:0006818) | 2.81073761 |
155 | termination of RNA polymerase III transcription (GO:0006386) | 2.80900109 |
156 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.80900109 |
157 | respiratory chain complex IV assembly (GO:0008535) | 2.75667414 |
158 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.75418793 |
159 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.75418793 |
160 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 2.73434059 |
161 | positive regulation of icosanoid secretion (GO:0032305) | 2.69449417 |
162 | protein localization to mitochondrion (GO:0070585) | 2.69103424 |
163 | mitochondrial calcium ion transport (GO:0006851) | 2.67825805 |
Rank | Gene Set | Z-score |
---|---|---|
1 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 5.38263450 |
2 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.24114853 |
3 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 4.06731855 |
4 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 2.84011039 |
5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.67840048 |
6 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 2.64488590 |
7 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.62033988 |
8 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 2.47982479 |
9 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.29100574 |
10 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.28546590 |
11 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.18517371 |
12 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.17893123 |
13 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.07055812 |
14 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.03222329 |
15 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.00559052 |
16 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.98897426 |
17 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.97635524 |
18 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.90425693 |
19 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.82760554 |
20 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.82688521 |
21 | * TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.81144897 |
22 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.80175729 |
23 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.78728427 |
24 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.78016317 |
25 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.76472926 |
26 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.76210854 |
27 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.75072779 |
28 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.72544508 |
29 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.72280138 |
30 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.70294475 |
31 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.68753125 |
32 | * LXR_22292898_ChIP-Seq_THP-1_Human | 1.68595735 |
33 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.61987663 |
34 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.60078485 |
35 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.56808498 |
36 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.55599965 |
37 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.53851413 |
38 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.53350028 |
39 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.51782124 |
40 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.50533559 |
41 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.50442841 |
42 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.49592414 |
43 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.49033628 |
44 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.47969632 |
45 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.45983601 |
46 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.45546756 |
47 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.43665888 |
48 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.43650566 |
49 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.41009134 |
50 | * CTCF_20526341_ChIP-Seq_ESCs_Human | 1.39953696 |
51 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.38710267 |
52 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.38612362 |
53 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.35211664 |
54 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.32789651 |
55 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.31802405 |
56 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.31706656 |
57 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.31171610 |
58 | * ATF3_27146783_Chip-Seq_COLON_Human | 1.28496766 |
59 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.27617600 |
60 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.27430171 |
61 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.27317469 |
62 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.26247613 |
63 | * RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.26056678 |
64 | * BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.25993637 |
65 | * P68_20966046_ChIP-Seq_HELA_Human | 1.24690038 |
66 | * CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.24516295 |
67 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.23513023 |
68 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.23449154 |
69 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.22097713 |
70 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.21714338 |
71 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.21300890 |
72 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 1.20034167 |
73 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.19693058 |
74 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 1.19627431 |
75 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.19390445 |
76 | MAF_26560356_Chip-Seq_TH2_Human | 1.19317921 |
77 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.18994431 |
78 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.17543445 |
79 | MYC_22102868_ChIP-Seq_BL_Human | 1.17029776 |
80 | * CTCF_21964334_ChIP-Seq_BJAB-B_Human | 1.16543751 |
81 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.16483543 |
82 | * SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 1.15848506 |
83 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.15604991 |
84 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.14085768 |
85 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.13990019 |
86 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.13776939 |
87 | P300_27268052_Chip-Seq_Bcells_Human | 1.13459410 |
88 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.12940756 |
89 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.12849371 |
90 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.11823209 |
91 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.10237473 |
92 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.09763365 |
93 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.08987153 |
94 | ETS1_21867929_ChIP-Seq_TH2_Mouse | 1.08078540 |
95 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 1.07585148 |
96 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.07543167 |
97 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.07243405 |
98 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.06283434 |
99 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.05719233 |
100 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.05165612 |
101 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.04961672 |
102 | * KDM2B_26808549_Chip-Seq_DND41_Human | 1.04737224 |
103 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.04338497 |
104 | * CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.04179860 |
105 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.03989933 |
106 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 1.03805882 |
107 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.03482979 |
108 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.03296581 |
109 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.03031172 |
110 | * CTCF_21964334_Chip-Seq_Bcells_Human | 1.02983163 |
111 | SPI1_20517297_ChIP-Seq_HL60_Human | 1.02881324 |
112 | ERA_21632823_ChIP-Seq_H3396_Human | 1.02666888 |
113 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.02326328 |
114 | * EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.01859908 |
115 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 1.01211907 |
116 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 1.00770242 |
117 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.00316730 |
118 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.98385137 |
119 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.98385137 |
120 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.98371576 |
121 | * SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.98351454 |
122 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.96977214 |
123 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.96975744 |
124 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.96949304 |
125 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.95653114 |
126 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.95170383 |
127 | SA1_27219007_Chip-Seq_Bcells_Human | 0.94647410 |
128 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.94181756 |
129 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.93880249 |
130 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.93808788 |
131 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92997799 |
132 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.92230311 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002837_dystrophic_cardiac_calcinosis | 5.02780639 |
2 | MP0003646_muscle_fatigue | 4.75917912 |
3 | MP0004084_abnormal_cardiac_muscle | 4.04147095 |
4 | MP0000751_myopathy | 3.63995704 |
5 | MP0003806_abnormal_nucleotide_metabolis | 3.41997806 |
6 | MP0000749_muscle_degeneration | 3.28911797 |
7 | MP0004215_abnormal_myocardial_fiber | 3.25495312 |
8 | MP0005330_cardiomyopathy | 3.23615274 |
9 | MP0005360_urolithiasis | 3.13705638 |
10 | MP0006036_abnormal_mitochondrial_physio | 2.93371487 |
11 | MP0004036_abnormal_muscle_relaxation | 2.90412330 |
12 | MP0002163_abnormal_gland_morphology | 2.60077571 |
13 | MP0002139_abnormal_hepatobiliary_system | 2.59570757 |
14 | MP0000750_abnormal_muscle_regeneration | 2.48308513 |
15 | MP0005085_abnormal_gallbladder_physiolo | 2.33003647 |
16 | MP0004087_abnormal_muscle_fiber | 2.30982208 |
17 | MP0002972_abnormal_cardiac_muscle | 2.22328363 |
18 | MP0009840_abnormal_foam_cell | 2.21051250 |
19 | MP0004858_abnormal_nervous_system | 2.20377823 |
20 | MP0002269_muscular_atrophy | 2.11869034 |
21 | MP0001544_abnormal_cardiovascular_syste | 2.06949921 |
22 | MP0005385_cardiovascular_system_phenoty | 2.06949921 |
23 | MP0008775_abnormal_heart_ventricle | 2.04737402 |
24 | MP0001968_abnormal_touch/_nociception | 1.98193760 |
25 | MP0003137_abnormal_impulse_conducting | 1.97762553 |
26 | MP0005332_abnormal_amino_acid | 1.94638792 |
27 | MP0002249_abnormal_larynx_morphology | 1.89976949 |
28 | MP0005365_abnormal_bile_salt | 1.89057500 |
29 | MP0010630_abnormal_cardiac_muscle | 1.85707234 |
30 | MP0005645_abnormal_hypothalamus_physiol | 1.83892523 |
31 | MP0005620_abnormal_muscle_contractility | 1.80919613 |
32 | MP0002106_abnormal_muscle_physiology | 1.77510253 |
33 | MP0003186_abnormal_redox_activity | 1.76878850 |
34 | MP0004130_abnormal_muscle_cell | 1.76618741 |
35 | MP0000747_muscle_weakness | 1.76134662 |
36 | MP0006035_abnormal_mitochondrial_morpho | 1.75035327 |
37 | MP0005083_abnormal_biliary_tract | 1.72830536 |
38 | MP0000678_abnormal_parathyroid_gland | 1.71333712 |
39 | MP0006138_congestive_heart_failure | 1.70731522 |
40 | MP0003221_abnormal_cardiomyocyte_apopto | 1.69609650 |
41 | MP0009333_abnormal_splenocyte_physiolog | 1.67858243 |
42 | MP0002653_abnormal_ependyma_morphology | 1.60551087 |
43 | MP0005646_abnormal_pituitary_gland | 1.59684822 |
44 | MP0005319_abnormal_enzyme/_coenzyme | 1.58859874 |
45 | MP0001905_abnormal_dopamine_level | 1.56380399 |
46 | MP0002736_abnormal_nociception_after | 1.55753992 |
47 | MP0009643_abnormal_urine_homeostasis | 1.55413692 |
48 | MP0008875_abnormal_xenobiotic_pharmacok | 1.55005968 |
49 | MP0005670_abnormal_white_adipose | 1.54957522 |
50 | MP0003879_abnormal_hair_cell | 1.52918489 |
51 | MP0004484_altered_response_of | 1.51754692 |
52 | MP0003705_abnormal_hypodermis_morpholog | 1.49095940 |
53 | MP0000759_abnormal_skeletal_muscle | 1.47478007 |
54 | MP0003011_delayed_dark_adaptation | 1.46139942 |
55 | MP0005451_abnormal_body_composition | 1.44988687 |
56 | MP0001873_stomach_inflammation | 1.39849879 |
57 | MP0005369_muscle_phenotype | 1.34923377 |
58 | MP0001346_abnormal_lacrimal_gland | 1.33344487 |
59 | MP0002876_abnormal_thyroid_physiology | 1.31210051 |
60 | MP0002234_abnormal_pharynx_morphology | 1.29962015 |
61 | MP0001666_abnormal_nutrient_absorption | 1.29951328 |
62 | MP0005666_abnormal_adipose_tissue | 1.27749526 |
63 | MP0005266_abnormal_metabolism | 1.27168194 |
64 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.25406045 |
65 | MP0003828_pulmonary_edema | 1.25289825 |
66 | MP0010329_abnormal_lipoprotein_level | 1.25219162 |
67 | MP0000681_abnormal_thyroid_gland | 1.25165592 |
68 | MP0004233_abnormal_muscle_weight | 1.24189741 |
69 | MP0003567_abnormal_fetal_cardiomyocyte | 1.23629653 |
70 | MP0003191_abnormal_cellular_cholesterol | 1.23449378 |
71 | MP0005623_abnormal_meninges_morphology | 1.21637751 |
72 | MP0003195_calcinosis | 1.19727407 |
73 | MP0010030_abnormal_orbit_morphology | 1.16461653 |
74 | MP0004145_abnormal_muscle_electrophysio | 1.11668584 |
75 | MP0005379_endocrine/exocrine_gland_phen | 1.11376023 |
76 | MP0000343_altered_response_to | 1.11195154 |
77 | MP0004043_abnormal_pH_regulation | 1.10629676 |
78 | MP0004185_abnormal_adipocyte_glucose | 1.10447801 |
79 | MP0004085_abnormal_heartbeat | 1.10019679 |
80 | MP0005636_abnormal_mineral_homeostasis | 1.09661386 |
81 | MP0002148_abnormal_hypersensitivity_rea | 1.06957513 |
82 | MP0003656_abnormal_erythrocyte_physiolo | 1.05407651 |
83 | MP0005165_increased_susceptibility_to | 1.03969691 |
84 | MP0001756_abnormal_urination | 1.03402643 |
85 | MP0004019_abnormal_vitamin_homeostasis | 1.02985279 |
86 | MP0000049_abnormal_middle_ear | 1.02070509 |
87 | MP0005058_abnormal_lysosome_morphology | 1.01910075 |
88 | MP0002638_abnormal_pupillary_reflex | 1.01208449 |
89 | MP0002822_catalepsy | 1.00970400 |
90 | MP0009379_abnormal_foot_pigmentation | 1.00219538 |
91 | MP0002332_abnormal_exercise_endurance | 0.99990126 |
92 | MP0009745_abnormal_behavioral_response | 0.99224576 |
93 | MP0002160_abnormal_reproductive_system | 0.98345344 |
94 | MP0003252_abnormal_bile_duct | 0.98226017 |
95 | MP0008872_abnormal_physiological_respon | 0.97842407 |
96 | MP0002118_abnormal_lipid_homeostasis | 0.96810919 |
97 | MP0001502_abnormal_circadian_rhythm | 0.96119944 |
98 | MP0005671_abnormal_response_to | 0.95961098 |
99 | MP0002733_abnormal_thermal_nociception | 0.95240879 |
100 | MP0002127_abnormal_cardiovascular_syste | 0.93529704 |
101 | MP0004147_increased_porphyrin_level | 0.90985150 |
102 | MP0002064_seizures | 0.88999853 |
103 | MP0000609_abnormal_liver_physiology | 0.87946476 |
104 | MP0003693_abnormal_embryo_hatching | 0.86653500 |
105 | MP0006292_abnormal_olfactory_placode | 0.86311784 |
106 | MP0003315_abnormal_perineum_morphology | 0.86096008 |
107 | MP0009278_abnormal_bone_marrow | 0.85633477 |
108 | MP0000230_abnormal_systemic_arterial | 0.85163724 |
109 | MP0001970_abnormal_pain_threshold | 0.83655878 |
110 | MP0000003_abnormal_adipose_tissue | 0.81377701 |
111 | MP0004510_myositis | 0.80552512 |
112 | MP0001853_heart_inflammation | 0.80273829 |
113 | MP0001188_hyperpigmentation | 0.79864124 |
114 | MP0005084_abnormal_gallbladder_morpholo | 0.79669463 |
115 | MP0001764_abnormal_homeostasis | 0.79312567 |
116 | MP0005423_abnormal_somatic_nervous | 0.78328583 |
117 | MP0000538_abnormal_urinary_bladder | 0.77428991 |
118 | MP0003279_aneurysm | 0.77174306 |
119 | MP0001881_abnormal_mammary_gland | 0.76937974 |
120 | MP0004142_abnormal_muscle_tone | 0.76674807 |
121 | MP0000358_abnormal_cell_content/ | 0.76495997 |
122 | MP0002277_abnormal_respiratory_mucosa | 0.76094698 |
123 | MP0003566_abnormal_cell_adhesion | 0.75054245 |
124 | MP0000733_abnormal_muscle_development | 0.73963363 |
125 | MP0010368_abnormal_lymphatic_system | 0.73949788 |
126 | MP0005375_adipose_tissue_phenotype | 0.73598404 |
127 | MP0000266_abnormal_heart_morphology | 0.73141443 |
128 | MP0003075_altered_response_to | 0.71514784 |
129 | MP0005377_hearing/vestibular/ear_phenot | 0.70256157 |
130 | MP0003878_abnormal_ear_physiology | 0.70256157 |
131 | MP0005376_homeostasis/metabolism_phenot | 0.69756704 |
132 | MP0000685_abnormal_immune_system | 0.68986232 |
133 | MP0001765_abnormal_ion_homeostasis | 0.67956919 |
134 | MP0000598_abnormal_liver_morphology | 0.67674931 |
135 | MP0001664_abnormal_digestion | 0.66879116 |
136 | MP0006276_abnormal_autonomic_nervous | 0.65380180 |
137 | MP0004957_abnormal_blastocyst_morpholog | 0.64979293 |
138 | MP0002272_abnormal_nervous_system | 0.64863887 |
139 | MP0002078_abnormal_glucose_homeostasis | 0.64146889 |
140 | MP0009053_abnormal_anal_canal | 0.60308793 |
141 | MP0002136_abnormal_kidney_physiology | 0.57948030 |
142 | MP0009642_abnormal_blood_homeostasis | 0.57776575 |
143 | MP0002796_impaired_skin_barrier | 0.54499781 |
144 | MP0001663_abnormal_digestive_system | 0.51817360 |
145 | MP0008469_abnormal_protein_level | 0.51496758 |
146 | MP0003283_abnormal_digestive_organ | 0.50671851 |
147 | MP0002971_abnormal_brown_adipose | 0.49532596 |
148 | MP0002970_abnormal_white_adipose | 0.49320863 |
149 | MP0002128_abnormal_blood_circulation | 0.48936363 |
150 | MP0000013_abnormal_adipose_tissue | 0.48845665 |
151 | MP0000490_abnormal_crypts_of | 0.48315276 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Sudden death (HP:0001699) | 4.94116366 |
2 | Hepatic necrosis (HP:0002605) | 4.81345847 |
3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.49272154 |
4 | Acute necrotizing encephalopathy (HP:0006965) | 4.46005686 |
5 | Hepatocellular necrosis (HP:0001404) | 4.45185847 |
6 | Ventricular tachycardia (HP:0004756) | 4.39349938 |
7 | Acute encephalopathy (HP:0006846) | 4.29251496 |
8 | Myoglobinuria (HP:0002913) | 4.19658002 |
9 | Mitochondrial inheritance (HP:0001427) | 4.19656536 |
10 | Increased muscle lipid content (HP:0009058) | 3.92828989 |
11 | Increased CSF lactate (HP:0002490) | 3.86188004 |
12 | Muscle fiber inclusion bodies (HP:0100299) | 3.85212708 |
13 | Rhabdomyolysis (HP:0003201) | 3.80120040 |
14 | Palpitations (HP:0001962) | 3.79514493 |
15 | Cerebral edema (HP:0002181) | 3.71120845 |
16 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 3.67726805 |
17 | Increased intramyocellular lipid droplets (HP:0012240) | 3.64560826 |
18 | Myopathic facies (HP:0002058) | 3.63910894 |
19 | Dicarboxylic aciduria (HP:0003215) | 3.63082586 |
20 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 3.63082586 |
21 | Nemaline bodies (HP:0003798) | 3.62699449 |
22 | Exercise-induced muscle cramps (HP:0003710) | 3.61293332 |
23 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.56785105 |
24 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.56785105 |
25 | Progressive macrocephaly (HP:0004481) | 3.47177457 |
26 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.46087157 |
27 | Calf muscle hypertrophy (HP:0008981) | 3.45549637 |
28 | Lactic acidosis (HP:0003128) | 3.44919762 |
29 | Lipoatrophy (HP:0100578) | 3.40059520 |
30 | Exercise-induced myalgia (HP:0003738) | 3.39761631 |
31 | Muscle fiber splitting (HP:0003555) | 3.32690126 |
32 | Right ventricular cardiomyopathy (HP:0011663) | 3.27329858 |
33 | Hypoglycemic coma (HP:0001325) | 3.21342098 |
34 | Respiratory failure (HP:0002878) | 3.16039852 |
35 | Lipid accumulation in hepatocytes (HP:0006561) | 3.14881481 |
36 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.11541474 |
37 | Ragged-red muscle fibers (HP:0003200) | 3.10085689 |
38 | Hyperammonemia (HP:0001987) | 3.10041423 |
39 | Ketoacidosis (HP:0001993) | 3.09944419 |
40 | Generalized aminoaciduria (HP:0002909) | 3.07460230 |
41 | Muscle hypertrophy of the lower extremities (HP:0008968) | 3.07048200 |
42 | Exercise intolerance (HP:0003546) | 3.01812676 |
43 | Increased serum lactate (HP:0002151) | 2.95350522 |
44 | Ketosis (HP:0001946) | 2.95156032 |
45 | Dilated cardiomyopathy (HP:0001644) | 2.93927398 |
46 | Hyperglycinuria (HP:0003108) | 2.91176276 |
47 | Atrial fibrillation (HP:0005110) | 2.89469775 |
48 | Supraventricular tachycardia (HP:0004755) | 2.85470411 |
49 | Lethargy (HP:0001254) | 2.81784296 |
50 | Type 1 muscle fiber predominance (HP:0003803) | 2.81439654 |
51 | Abnormality of the calf musculature (HP:0001430) | 2.79445850 |
52 | Supraventricular arrhythmia (HP:0005115) | 2.79281217 |
53 | Asymmetric septal hypertrophy (HP:0001670) | 2.76775792 |
54 | Primary atrial arrhythmia (HP:0001692) | 2.75581443 |
55 | Subaortic stenosis (HP:0001682) | 2.74832460 |
56 | Abnormality of the left ventricular outflow tract (HP:0011103) | 2.74832460 |
57 | Increased hepatocellular lipid droplets (HP:0006565) | 2.74604619 |
58 | Ventricular fibrillation (HP:0001663) | 2.73957099 |
59 | Type II lissencephaly (HP:0007260) | 2.66049062 |
60 | Conjunctival hamartoma (HP:0100780) | 2.65567164 |
61 | Multiple enchondromatosis (HP:0005701) | 2.60294446 |
62 | Syncope (HP:0001279) | 2.60146094 |
63 | Myotonia (HP:0002486) | 2.55907615 |
64 | Abnormality of glycolysis (HP:0004366) | 2.55726133 |
65 | Increased serum pyruvate (HP:0003542) | 2.55726133 |
66 | Ventricular arrhythmia (HP:0004308) | 2.53531615 |
67 | Hyporeflexia of lower limbs (HP:0002600) | 2.51274157 |
68 | EMG: myopathic abnormalities (HP:0003458) | 2.50765372 |
69 | Nausea (HP:0002018) | 2.48680478 |
70 | Microretrognathia (HP:0000308) | 2.48151423 |
71 | Muscle stiffness (HP:0003552) | 2.46889559 |
72 | Glycosuria (HP:0003076) | 2.46057941 |
73 | Abnormality of urine glucose concentration (HP:0011016) | 2.46057941 |
74 | Abnormality of glycine metabolism (HP:0010895) | 2.45910495 |
75 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.45910495 |
76 | Distal arthrogryposis (HP:0005684) | 2.44837987 |
77 | Achilles tendon contracture (HP:0001771) | 2.42633572 |
78 | Testicular atrophy (HP:0000029) | 2.42557951 |
79 | 3-Methylglutaconic aciduria (HP:0003535) | 2.41289193 |
80 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 2.41220447 |
81 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.39107262 |
82 | Proximal tubulopathy (HP:0000114) | 2.38320608 |
83 | Increased connective tissue (HP:0009025) | 2.38054262 |
84 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.37736661 |
85 | Bundle branch block (HP:0011710) | 2.37454514 |
86 | Vomiting (HP:0002013) | 2.36515519 |
87 | Hyperthyroidism (HP:0000836) | 2.35489477 |
88 | Cerebral palsy (HP:0100021) | 2.34777214 |
89 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.34024477 |
90 | Prolonged QT interval (HP:0001657) | 2.31338306 |
91 | Bulbar palsy (HP:0001283) | 2.30855127 |
92 | Gout (HP:0001997) | 2.30162061 |
93 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.28064100 |
94 | CNS demyelination (HP:0007305) | 2.27840464 |
95 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 2.27635166 |
96 | Metabolic acidosis (HP:0001942) | 2.27571723 |
97 | Esophageal neoplasm (HP:0100751) | 2.26220092 |
98 | Neoplasm of head and neck (HP:0012288) | 2.26220092 |
99 | Atrioventricular block (HP:0001678) | 2.25302998 |
100 | Progressive microcephaly (HP:0000253) | 2.24961719 |
101 | Late onset (HP:0003584) | 2.24137056 |
102 | Abnormal number of erythroid precursors (HP:0012131) | 2.24115431 |
103 | Heart block (HP:0012722) | 2.20362769 |
104 | Difficulty climbing stairs (HP:0003551) | 2.18839580 |
105 | Macrocytic anemia (HP:0001972) | 2.16131327 |
106 | Progressive muscle weakness (HP:0003323) | 2.16070279 |
107 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.14714428 |
108 | Absent phalangeal crease (HP:0006109) | 2.14028019 |
109 | Hyperglycinemia (HP:0002154) | 2.13969523 |
110 | Abnormal atrioventricular conduction (HP:0005150) | 2.13435454 |
111 | Abnormality of the Achilles tendon (HP:0005109) | 2.13235729 |
112 | Type I transferrin isoform profile (HP:0003642) | 2.08262269 |
113 | Renal Fanconi syndrome (HP:0001994) | 2.05719109 |
114 | Round ear (HP:0100830) | 2.05046099 |
115 | Optic disc pallor (HP:0000543) | 2.04864412 |
116 | Opisthotonus (HP:0002179) | 2.04346181 |
117 | Neoplasm of the adrenal gland (HP:0100631) | 2.03723204 |
118 | Severe muscular hypotonia (HP:0006829) | 2.03592680 |
119 | Emotional lability (HP:0000712) | 2.02707811 |
120 | Truncus arteriosus (HP:0001660) | 1.98147367 |
121 | Ulnar deviation of the wrist (HP:0003049) | 1.98143982 |
122 | Abnormal cartilage morphology (HP:0002763) | 1.95371711 |
123 | Exertional dyspnea (HP:0002875) | 1.95059483 |
124 | Reticulocytopenia (HP:0001896) | 1.93487656 |
125 | Respiratory difficulties (HP:0002880) | 1.92847778 |
126 | Hyperphosphaturia (HP:0003109) | 1.92247419 |
127 | Pheochromocytoma (HP:0002666) | 1.90724359 |
128 | Limb-girdle muscle atrophy (HP:0003797) | 1.90331454 |
129 | Concave nail (HP:0001598) | 1.89957722 |
130 | Methylmalonic aciduria (HP:0012120) | 1.89588136 |
131 | Pallor (HP:0000980) | 1.86556470 |
132 | Distal lower limb muscle weakness (HP:0009053) | 1.84411272 |
133 | Abnormal protein glycosylation (HP:0012346) | 1.83651000 |
134 | Abnormal glycosylation (HP:0012345) | 1.83651000 |
135 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.83651000 |
136 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.83651000 |
137 | Hypertensive crisis (HP:0100735) | 1.81870430 |
138 | Broad distal phalanx of finger (HP:0009836) | 1.79691089 |
139 | Myokymia (HP:0002411) | 1.79267297 |
140 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.78425696 |
141 | Cerebellar dysplasia (HP:0007033) | 1.74807500 |
142 | Congenital malformation of the right heart (HP:0011723) | 1.74559496 |
143 | Double outlet right ventricle (HP:0001719) | 1.74559496 |
144 | Calcaneovalgus deformity (HP:0001848) | 1.72134467 |
145 | Leukodystrophy (HP:0002415) | 1.70854995 |
146 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.68809552 |
147 | Generalized muscle weakness (HP:0003324) | 1.68019552 |
148 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.67470992 |
149 | Mesangial abnormality (HP:0001966) | 1.66819205 |
150 | Muscle fiber atrophy (HP:0100295) | 1.66368465 |
151 | Neck muscle weakness (HP:0000467) | 1.65539731 |
152 | Hyperalaninemia (HP:0003348) | 1.64887909 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BCKDK | 4.75548439 |
2 | VRK2 | 4.13515126 |
3 | NME2 | 3.74010683 |
4 | MYLK | 3.47556328 |
5 | TRIB3 | 3.46830291 |
6 | PKN2 | 3.19013894 |
7 | TTN | 3.01500177 |
8 | LMTK2 | 2.84172267 |
9 | NEK1 | 2.65075238 |
10 | ERN1 | 2.43786122 |
11 | OBSCN | 2.31916322 |
12 | KDR | 2.25383086 |
13 | MAP3K11 | 2.01508020 |
14 | PDK3 | 1.99896731 |
15 | PDK4 | 1.99896731 |
16 | PHKG2 | 1.99417632 |
17 | PHKG1 | 1.99417632 |
18 | PIM2 | 1.96246527 |
19 | ILK | 1.90526722 |
20 | MAPKAPK3 | 1.87099788 |
21 | CDK19 | 1.72258722 |
22 | TESK2 | 1.67691844 |
23 | SMG1 | 1.62679695 |
24 | BUB1 | 1.62127828 |
25 | NME1 | 1.57314449 |
26 | ARAF | 1.50120184 |
27 | IRAK3 | 1.44604704 |
28 | TESK1 | 1.43638868 |
29 | LRRK2 | 1.39421847 |
30 | DAPK3 | 1.32538173 |
31 | WNK4 | 1.31881268 |
32 | MAP2K3 | 1.31797676 |
33 | FLT3 | 1.26461001 |
34 | STK16 | 1.25411589 |
35 | PIK3CA | 1.25147615 |
36 | MAP2K2 | 1.22047424 |
37 | TAOK3 | 1.17355393 |
38 | TAOK1 | 1.14007595 |
39 | PINK1 | 1.13232362 |
40 | ZAK | 1.12484639 |
41 | LIMK1 | 1.09219949 |
42 | PRKD3 | 1.07627224 |
43 | MUSK | 1.07532671 |
44 | CDK8 | 1.04276303 |
45 | EIF2AK1 | 1.02807721 |
46 | EPHB2 | 1.02636374 |
47 | TIE1 | 1.00781417 |
48 | MAP3K3 | 0.95340052 |
49 | VRK1 | 0.94173635 |
50 | MAP3K10 | 0.90921906 |
51 | CSNK1G3 | 0.90040178 |
52 | ADRBK2 | 0.89811547 |
53 | PDK2 | 0.89739503 |
54 | STK24 | 0.84807127 |
55 | IKBKB | 0.84676048 |
56 | PAK4 | 0.83690662 |
57 | BRAF | 0.83591846 |
58 | DAPK1 | 0.82998372 |
59 | PRKG2 | 0.82714709 |
60 | ABL2 | 0.82316161 |
61 | RPS6KA5 | 0.81937550 |
62 | MAP2K6 | 0.80607503 |
63 | MAP3K9 | 0.80078273 |
64 | DMPK | 0.79914173 |
65 | WEE1 | 0.79784681 |
66 | MAPKAPK5 | 0.79624688 |
67 | SCYL2 | 0.77374263 |
68 | RPS6KB2 | 0.77284909 |
69 | GRK5 | 0.76320223 |
70 | MAP4K1 | 0.76256349 |
71 | RIPK1 | 0.72343839 |
72 | TAOK2 | 0.70986519 |
73 | TBK1 | 0.70300192 |
74 | MAP4K2 | 0.67967847 |
75 | MAPK11 | 0.67367425 |
76 | KIT | 0.66909894 |
77 | MAP3K13 | 0.66729833 |
78 | TLK1 | 0.65932392 |
79 | MAPK12 | 0.65485210 |
80 | MAP3K12 | 0.65172617 |
81 | MAP3K5 | 0.64162152 |
82 | ZAP70 | 0.64054427 |
83 | EEF2K | 0.63620887 |
84 | MAP3K7 | 0.63338270 |
85 | TNK2 | 0.63328652 |
86 | CCNB1 | 0.61277994 |
87 | CAMK2D | 0.60028178 |
88 | NUAK1 | 0.59880368 |
89 | MAP3K8 | 0.58103284 |
90 | PRKD1 | 0.57979567 |
91 | PRKD2 | 0.57351178 |
92 | AKT2 | 0.56762651 |
93 | PAK1 | 0.56165145 |
94 | RPS6KL1 | 0.55170362 |
95 | RPS6KC1 | 0.55170362 |
96 | AURKA | 0.52806444 |
97 | GRK6 | 0.52632660 |
98 | DYRK2 | 0.52246094 |
99 | CHEK2 | 0.50890704 |
100 | RPS6KA6 | 0.50759627 |
101 | HIPK2 | 0.50687994 |
102 | GRK1 | 0.49808883 |
103 | PTK6 | 0.48874428 |
104 | ROCK1 | 0.47843010 |
105 | MAP2K1 | 0.46287838 |
106 | CSNK1A1L | 0.46176808 |
107 | DAPK2 | 0.46064295 |
108 | CAMK2B | 0.45792597 |
109 | ADRBK1 | 0.45439473 |
110 | RPS6KA4 | 0.45143642 |
111 | MST1R | 0.45093128 |
112 | BLK | 0.43060474 |
113 | BRSK1 | 0.42905746 |
114 | SIK1 | 0.42804851 |
115 | AURKB | 0.42801974 |
116 | FGFR4 | 0.42772392 |
117 | PIK3CG | 0.42032626 |
118 | TAF1 | 0.41830353 |
119 | MAP3K1 | 0.41742467 |
120 | KSR2 | 0.41678794 |
121 | CSNK1G2 | 0.41642572 |
122 | PAK3 | 0.41599013 |
123 | CDC7 | 0.41522877 |
124 | TXK | 0.41086158 |
125 | CAMK2G | 0.40565721 |
126 | IRAK4 | 0.40138593 |
127 | PDPK1 | 0.39663967 |
128 | PKN1 | 0.38972742 |
129 | STK38L | 0.38608589 |
130 | CDC42BPA | 0.37563916 |
131 | CDK11A | 0.37372950 |
132 | CSNK2A1 | 0.35659715 |
133 | RPS6KA2 | 0.33878210 |
134 | CSNK1G1 | 0.33695894 |
135 | CSNK2A2 | 0.32496602 |
136 | PRKCI | 0.32247812 |
137 | DYRK3 | 0.31835162 |
138 | STK4 | 0.31808446 |
139 | MAPK4 | 0.31306785 |
140 | RPS6KA1 | 0.31034191 |
141 | PTK2B | 0.30552000 |
142 | MAPKAPK2 | 0.29806289 |
143 | CAMK1 | 0.27359447 |
144 | NEK9 | 0.27005800 |
145 | EIF2AK3 | 0.26280827 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 4.59882480 |
2 | * Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.89058513 |
3 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 3.83072707 |
4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.78555295 |
5 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.86345232 |
6 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.78603605 |
7 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.69248929 |
8 | Ribosome_Homo sapiens_hsa03010 | 2.67316437 |
9 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.65399697 |
10 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.64654162 |
11 | Carbon metabolism_Homo sapiens_hsa01200 | 2.60310717 |
12 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.57530470 |
13 | Alzheimers disease_Homo sapiens_hsa05010 | 2.52791239 |
14 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.45809138 |
15 | Huntingtons disease_Homo sapiens_hsa05016 | 2.42794641 |
16 | Pyruvate metabolism_Homo sapiens_hsa00620 | 2.13239889 |
17 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.81062169 |
18 | Proteasome_Homo sapiens_hsa03050 | 1.80629799 |
19 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.69077524 |
20 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.66760873 |
21 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.60429411 |
22 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.59400368 |
23 | Sulfur relay system_Homo sapiens_hsa04122 | 1.54561566 |
24 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.51405448 |
25 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.45838363 |
26 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.42961857 |
27 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.41184245 |
28 | Homologous recombination_Homo sapiens_hsa03440 | 1.37555966 |
29 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.35406457 |
30 | Peroxisome_Homo sapiens_hsa04146 | 1.32759189 |
31 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.30321825 |
32 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.29973805 |
33 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.26591965 |
34 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.24402677 |
35 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.19771921 |
36 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.19596945 |
37 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.19147742 |
38 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.19088169 |
39 | Galactose metabolism_Homo sapiens_hsa00052 | 1.18094758 |
40 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.17082200 |
41 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.15570252 |
42 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.14086126 |
43 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.13767086 |
44 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.13722663 |
45 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.09890260 |
46 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.05775856 |
47 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.04109915 |
48 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.03413985 |
49 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.02372422 |
50 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.00267945 |
51 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.97042611 |
52 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.95498548 |
53 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.95331648 |
54 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.94825307 |
55 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.91638250 |
56 | DNA replication_Homo sapiens_hsa03030 | 0.91375792 |
57 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.87889706 |
58 | Asthma_Homo sapiens_hsa05310 | 0.81702907 |
59 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.80975588 |
60 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.80016972 |
61 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.78244414 |
62 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.72395505 |
63 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.69492723 |
64 | RNA polymerase_Homo sapiens_hsa03020 | 0.67180798 |
65 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.65972984 |
66 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.64053377 |
67 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.63540371 |
68 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.63253850 |
69 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.63070781 |
70 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.61075583 |
71 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.60689836 |
72 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.60523688 |
73 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.60419267 |
74 | Bile secretion_Homo sapiens_hsa04976 | 0.57751169 |
75 | Allograft rejection_Homo sapiens_hsa05330 | 0.57497194 |
76 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.56871606 |
77 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.50840837 |
78 | Phototransduction_Homo sapiens_hsa04744 | 0.47565204 |
79 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.47470404 |
80 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.46238649 |
81 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.45341443 |
82 | Base excision repair_Homo sapiens_hsa03410 | 0.44972632 |
83 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.42916272 |
84 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.41025490 |
85 | Histidine metabolism_Homo sapiens_hsa00340 | 0.40713245 |
86 | Mismatch repair_Homo sapiens_hsa03430 | 0.40474078 |
87 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.39220617 |
88 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.37480926 |
89 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.33830379 |
90 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.33327270 |
91 | Purine metabolism_Homo sapiens_hsa00230 | 0.31561908 |
92 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.31113293 |
93 | Viral myocarditis_Homo sapiens_hsa05416 | 0.30248185 |
94 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.30219493 |
95 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.29420648 |
96 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.29361623 |
97 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.28862294 |
98 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.28379919 |
99 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.28235425 |
100 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.27733672 |
101 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.27419834 |
102 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.27250865 |
103 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.26965441 |
104 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.26483539 |
105 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.24293956 |
106 | Insulin resistance_Homo sapiens_hsa04931 | 0.23311703 |
107 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.21755752 |
108 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.21692104 |
109 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.19756388 |
110 | Retinol metabolism_Homo sapiens_hsa00830 | 0.19431653 |
111 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.18709979 |
112 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.18697086 |
113 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.16528200 |
114 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.14002663 |
115 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.13872664 |
116 | Lysine degradation_Homo sapiens_hsa00310 | 0.12950758 |
117 | Bladder cancer_Homo sapiens_hsa05219 | 0.12319964 |
118 | Mineral absorption_Homo sapiens_hsa04978 | 0.11289077 |
119 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.11028290 |
120 | Thyroid cancer_Homo sapiens_hsa05216 | 0.10697197 |
121 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.10225475 |
122 | Protein export_Homo sapiens_hsa03060 | 0.08777197 |
123 | Spliceosome_Homo sapiens_hsa03040 | 0.08152963 |
124 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.07763143 |
125 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.06068675 |
126 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.03619019 |
127 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.03462545 |
128 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | -0.0070858 |