ATP5D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the delta subunit of the catalytic core. Alternatively spliced transcript variants encoding the same isoform have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.54535605
2* ATP synthesis coupled proton transport (GO:0015986)6.18579416
3* energy coupled proton transport, down electrochemical gradient (GO:0015985)6.18579416
4tricarboxylic acid cycle (GO:0006099)5.89699541
5* respiratory electron transport chain (GO:0022904)5.77292196
6deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.63421534
7* electron transport chain (GO:0022900)5.62853863
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.53569312
9* oxidative phosphorylation (GO:0006119)5.31188478
10sarcomere organization (GO:0045214)5.20220954
11NADH metabolic process (GO:0006734)4.90621888
12lysine catabolic process (GO:0006554)4.41751729
13lysine metabolic process (GO:0006553)4.41751729
14GTP biosynthetic process (GO:0006183)4.40218165
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.27201737
16mitochondrial respiratory chain complex I assembly (GO:0032981)4.27201737
17NADH dehydrogenase complex assembly (GO:0010257)4.27201737
18cellular protein complex disassembly (GO:0043624)4.24053513
19actin-myosin filament sliding (GO:0033275)4.09784472
20muscle filament sliding (GO:0030049)4.09784472
212-oxoglutarate metabolic process (GO:0006103)4.07721423
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.02584858
23cardiac myofibril assembly (GO:0055003)4.00767363
24oxaloacetate metabolic process (GO:0006107)3.98788313
25maturation of SSU-rRNA (GO:0030490)3.98182602
26UTP biosynthetic process (GO:0006228)3.97808217
27* ATP biosynthetic process (GO:0006754)3.96257844
28pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.91698681
29creatine metabolic process (GO:0006600)3.84904615
30viral transcription (GO:0019083)3.81791089
31metallo-sulfur cluster assembly (GO:0031163)3.78786355
32iron-sulfur cluster assembly (GO:0016226)3.78786355
33UTP metabolic process (GO:0046051)3.77336014
34tricarboxylic acid metabolic process (GO:0072350)3.76355972
35aspartate family amino acid catabolic process (GO:0009068)3.76194229
36carnitine shuttle (GO:0006853)3.72707477
37fatty acid beta-oxidation (GO:0006635)3.72410143
38guanosine-containing compound biosynthetic process (GO:1901070)3.70034417
39translational initiation (GO:0006413)3.66971141
40protein complex disassembly (GO:0043241)3.64807274
41translational termination (GO:0006415)3.62369574
42succinate metabolic process (GO:0006105)3.60901813
43cellular ketone body metabolic process (GO:0046950)3.58341872
44bundle of His cell to Purkinje myocyte communication (GO:0086069)3.56564037
45cardiac muscle contraction (GO:0060048)3.56437187
46ribosomal small subunit assembly (GO:0000028)3.55274020
47galactose catabolic process (GO:0019388)3.54493384
48glyoxylate metabolic process (GO:0046487)3.53937555
49ubiquinone metabolic process (GO:0006743)3.50818253
50positive regulation of prostaglandin secretion (GO:0032308)3.50544774
51GDP-mannose metabolic process (GO:0019673)3.49883688
52myofibril assembly (GO:0030239)3.49526274
53chaperone-mediated protein transport (GO:0072321)3.47840538
54translational elongation (GO:0006414)3.47082831
55DNA deamination (GO:0045006)3.46289884
56establishment of protein localization to mitochondrial membrane (GO:0090151)3.44344588
57pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.40885174
58ubiquinone biosynthetic process (GO:0006744)3.40721433
59quinone biosynthetic process (GO:1901663)3.40721433
60negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.39625397
61heart process (GO:0003015)3.39349562
62heart contraction (GO:0060047)3.39349562
63macromolecular complex disassembly (GO:0032984)3.36030586
64regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.35766667
65pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.33049274
66* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.32902740
67* purine nucleoside triphosphate biosynthetic process (GO:0009145)3.32810374
68negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.32484563
69fatty acid transmembrane transport (GO:1902001)3.31293516
70CTP metabolic process (GO:0046036)3.31176073
71CTP biosynthetic process (GO:0006241)3.31176073
72translation (GO:0006412)3.30914306
73base-excision repair, AP site formation (GO:0006285)3.30227202
74cardiac muscle cell development (GO:0055013)3.28085017
75branched-chain amino acid catabolic process (GO:0009083)3.26443058
76aerobic respiration (GO:0009060)3.22395869
77pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.21551034
78negative regulation of potassium ion transmembrane transport (GO:1901380)3.20672315
79positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.19940074
80fatty acid catabolic process (GO:0009062)3.19915481
81deoxyribonucleotide catabolic process (GO:0009264)3.18255262
82ventricular cardiac muscle cell action potential (GO:0086005)3.18190005
83* nucleoside triphosphate biosynthetic process (GO:0009142)3.18029137
84protein neddylation (GO:0045116)3.17130484
85protein targeting to membrane (GO:0006612)3.16347551
86fatty acid oxidation (GO:0019395)3.15547271
87actin-mediated cell contraction (GO:0070252)3.15270671
88* purine nucleoside monophosphate biosynthetic process (GO:0009127)3.14983690
89* purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.14983690
90protein targeting to mitochondrion (GO:0006626)3.13485641
91regulation of mitochondrial translation (GO:0070129)3.11958650
92cardiac muscle tissue morphogenesis (GO:0055008)3.11921422
93cytidine metabolic process (GO:0046087)3.11903461
94cytidine catabolic process (GO:0006216)3.11903461
95cytidine deamination (GO:0009972)3.11903461
96SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.10350402
97* ribonucleoside triphosphate biosynthetic process (GO:0009201)3.10338962
98heme biosynthetic process (GO:0006783)3.09088166
99inner mitochondrial membrane organization (GO:0007007)3.08825941
100ketone body metabolic process (GO:1902224)3.08430404
101lipid oxidation (GO:0034440)3.08115604
102branched-chain amino acid metabolic process (GO:0009081)3.08007522
103peptidyl-histidine modification (GO:0018202)3.07483903
104protein targeting to ER (GO:0045047)3.07455236
105regulation of fatty acid oxidation (GO:0046320)3.06900595
106establishment of protein localization to mitochondrion (GO:0072655)3.06612023
107pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.06604560
108ribosomal small subunit biogenesis (GO:0042274)3.06374266
109short-chain fatty acid metabolic process (GO:0046459)3.06001671
110cytochrome complex assembly (GO:0017004)3.05771447
111regulation of cellular respiration (GO:0043457)3.05702787
112valine metabolic process (GO:0006573)3.05475453
113nucleotide salvage (GO:0043173)3.04396597
114regulation of coenzyme metabolic process (GO:0051196)3.03609408
115regulation of cofactor metabolic process (GO:0051193)3.03609408
116cardiac cell development (GO:0055006)3.03242613
117regulation of acyl-CoA biosynthetic process (GO:0050812)3.02239966
118heart trabecula formation (GO:0060347)3.02051376
119carnitine metabolic process (GO:0009437)3.00830678
120pyrimidine nucleotide catabolic process (GO:0006244)3.00225744
121* hydrogen ion transmembrane transport (GO:1902600)2.99761952
122acetyl-CoA metabolic process (GO:0006084)2.99485018
123cotranslational protein targeting to membrane (GO:0006613)2.99330882
124regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.99036352
125nucleoside diphosphate biosynthetic process (GO:0009133)2.97894886
126cellular component biogenesis (GO:0044085)2.97309159
127purine deoxyribonucleotide catabolic process (GO:0009155)2.97218903
128ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.96882174
129pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.96319971
130amino-acid betaine transport (GO:0015838)2.96253871
131carnitine transport (GO:0015879)2.96253871
132purine nucleotide salvage (GO:0032261)2.94043182
133establishment of protein localization to endoplasmic reticulum (GO:0072599)2.93245214
134actomyosin structure organization (GO:0031032)2.92769640
135regulation of skeletal muscle contraction (GO:0014819)2.92555245
136protein localization to endoplasmic reticulum (GO:0070972)2.92450973
137protein complex biogenesis (GO:0070271)2.92039179
138viral life cycle (GO:0019058)2.91094160
139negative regulation of B cell apoptotic process (GO:0002903)2.90744877
140carnitine transmembrane transport (GO:1902603)2.90570878
141mitochondrial respiratory chain complex assembly (GO:0033108)2.90304363
142regulation of oxidative phosphorylation (GO:0002082)2.88988838
143gluconeogenesis (GO:0006094)2.88947755
144erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.88928718
145L-phenylalanine metabolic process (GO:0006558)2.88928718
146pseudouridine synthesis (GO:0001522)2.87285339
147deoxyribose phosphate biosynthetic process (GO:0046385)2.86949676
1482-deoxyribonucleotide biosynthetic process (GO:0009265)2.86949676
149* proton transport (GO:0015992)2.86041149
150regulation of actin filament-based movement (GO:1903115)2.85622256
151* mitochondrial transport (GO:0006839)2.85352758
152sulfur amino acid catabolic process (GO:0000098)2.84879635
153deoxyribose phosphate catabolic process (GO:0046386)2.82870170
154* hydrogen transport (GO:0006818)2.81073761
155transcription elongation from RNA polymerase III promoter (GO:0006385)2.80900109
156termination of RNA polymerase III transcription (GO:0006386)2.80900109
157respiratory chain complex IV assembly (GO:0008535)2.75667414
158RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.75418793
159tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.75418793
1602-deoxyribonucleotide metabolic process (GO:0009394)2.73434059
161positive regulation of icosanoid secretion (GO:0032305)2.69449417
162protein localization to mitochondrion (GO:0070585)2.69103424
163mitochondrial calcium ion transport (GO:0006851)2.67825805

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.38263450
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.24114853
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.06731855
4* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.84011039
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.67840048
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.64488590
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.62033988
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.47982479
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.29100574
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28546590
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18517371
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.17893123
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07055812
14ZNF263_19887448_ChIP-Seq_K562_Human2.03222329
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.00559052
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98897426
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.97635524
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.90425693
19NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.82760554
20CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.82688521
21* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81144897
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.80175729
23SRY_22984422_ChIP-ChIP_TESTIS_Rat1.78728427
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.78016317
25STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76472926
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76210854
27XRN2_22483619_ChIP-Seq_HELA_Human1.75072779
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72544508
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72280138
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70294475
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.68753125
32* LXR_22292898_ChIP-Seq_THP-1_Human1.68595735
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61987663
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60078485
35E2F1_20622854_ChIP-Seq_HELA_Human1.56808498
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55599965
37* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53851413
38SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.53350028
39* SRF_21415370_ChIP-Seq_HL-1_Mouse1.51782124
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.50533559
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50442841
42CTCF_27219007_Chip-Seq_Bcells_Human1.49592414
43LXR_22158963_ChIP-Seq_LIVER_Mouse1.49033628
44VDR_21846776_ChIP-Seq_THP-1_Human1.47969632
45DCP1A_22483619_ChIP-Seq_HELA_Human1.45983601
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.45546756
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43665888
48FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.43650566
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41009134
50* CTCF_20526341_ChIP-Seq_ESCs_Human1.39953696
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.38710267
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.38612362
53BCL6_27268052_Chip-Seq_Bcells_Human1.35211664
54RACK7_27058665_Chip-Seq_MCF-7_Human1.32789651
55YY1_22570637_ChIP-Seq_MALME-3M_Human1.31802405
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31706656
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.31171610
58* ATF3_27146783_Chip-Seq_COLON_Human1.28496766
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27617600
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27430171
61GABP_19822575_ChIP-Seq_HepG2_Human1.27317469
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26247613
63* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.26056678
64* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25993637
65* P68_20966046_ChIP-Seq_HELA_Human1.24690038
66* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24516295
67BCOR_27268052_Chip-Seq_Bcells_Human1.23513023
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23449154
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22097713
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21714338
71* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21300890
72OCT4_18692474_ChIP-Seq_MEFs_Mouse1.20034167
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19693058
74SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19627431
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19390445
76MAF_26560356_Chip-Seq_TH2_Human1.19317921
77PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18994431
78* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17543445
79MYC_22102868_ChIP-Seq_BL_Human1.17029776
80* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.16543751
81* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16483543
82* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.15848506
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15604991
84PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14085768
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13990019
86SA1_27219007_Chip-Seq_ERYTHROID_Human1.13776939
87P300_27268052_Chip-Seq_Bcells_Human1.13459410
88SMC4_20622854_ChIP-Seq_HELA_Human1.12940756
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12849371
90MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.11823209
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10237473
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09763365
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08987153
94ETS1_21867929_ChIP-Seq_TH2_Mouse1.08078540
95RARA_24833708_ChIP-Seq_LIVER_Mouse1.07585148
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07543167
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.07243405
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06283434
99* FOXP1_21924763_ChIP-Seq_HESCs_Human1.05719233
100CIITA_25753668_ChIP-Seq_RAJI_Human1.05165612
101CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04961672
102* KDM2B_26808549_Chip-Seq_DND41_Human1.04737224
103NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04338497
104* CTCF_26484167_Chip-Seq_Bcells_Mouse1.04179860
105* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03989933
106STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03805882
107KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03482979
108CLOCK_20551151_ChIP-Seq_293T_Human1.03296581
109CREB1_26743006_Chip-Seq_LNCaP_Human1.03031172
110* CTCF_21964334_Chip-Seq_Bcells_Human1.02983163
111SPI1_20517297_ChIP-Seq_HL60_Human1.02881324
112ERA_21632823_ChIP-Seq_H3396_Human1.02666888
113ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02326328
114* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01859908
115RARB_24833708_ChIP-Seq_LIVER_Mouse1.01211907
116TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00770242
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00316730
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.98385137
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.98385137
120DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98371576
121* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98351454
122TTF2_22483619_ChIP-Seq_HELA_Human0.96977214
123ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96975744
124VDR_23849224_ChIP-Seq_CD4+_Human0.96949304
125CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95653114
126PHF8_20622854_ChIP-Seq_HELA_Human0.95170383
127SA1_27219007_Chip-Seq_Bcells_Human0.94647410
128FOXP3_21729870_ChIP-Seq_TREG_Human0.94181756
129* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93880249
130TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93808788
131RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92997799
132TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92230311

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.02780639
2MP0003646_muscle_fatigue4.75917912
3MP0004084_abnormal_cardiac_muscle4.04147095
4MP0000751_myopathy3.63995704
5MP0003806_abnormal_nucleotide_metabolis3.41997806
6MP0000749_muscle_degeneration3.28911797
7MP0004215_abnormal_myocardial_fiber3.25495312
8MP0005330_cardiomyopathy3.23615274
9MP0005360_urolithiasis3.13705638
10MP0006036_abnormal_mitochondrial_physio2.93371487
11MP0004036_abnormal_muscle_relaxation2.90412330
12MP0002163_abnormal_gland_morphology2.60077571
13MP0002139_abnormal_hepatobiliary_system2.59570757
14MP0000750_abnormal_muscle_regeneration2.48308513
15MP0005085_abnormal_gallbladder_physiolo2.33003647
16MP0004087_abnormal_muscle_fiber2.30982208
17MP0002972_abnormal_cardiac_muscle2.22328363
18MP0009840_abnormal_foam_cell2.21051250
19MP0004858_abnormal_nervous_system2.20377823
20MP0002269_muscular_atrophy2.11869034
21MP0001544_abnormal_cardiovascular_syste2.06949921
22MP0005385_cardiovascular_system_phenoty2.06949921
23MP0008775_abnormal_heart_ventricle2.04737402
24MP0001968_abnormal_touch/_nociception1.98193760
25MP0003137_abnormal_impulse_conducting1.97762553
26MP0005332_abnormal_amino_acid1.94638792
27MP0002249_abnormal_larynx_morphology1.89976949
28MP0005365_abnormal_bile_salt1.89057500
29MP0010630_abnormal_cardiac_muscle1.85707234
30MP0005645_abnormal_hypothalamus_physiol1.83892523
31MP0005620_abnormal_muscle_contractility1.80919613
32MP0002106_abnormal_muscle_physiology1.77510253
33MP0003186_abnormal_redox_activity1.76878850
34MP0004130_abnormal_muscle_cell1.76618741
35MP0000747_muscle_weakness1.76134662
36MP0006035_abnormal_mitochondrial_morpho1.75035327
37MP0005083_abnormal_biliary_tract1.72830536
38MP0000678_abnormal_parathyroid_gland1.71333712
39MP0006138_congestive_heart_failure1.70731522
40MP0003221_abnormal_cardiomyocyte_apopto1.69609650
41MP0009333_abnormal_splenocyte_physiolog1.67858243
42MP0002653_abnormal_ependyma_morphology1.60551087
43MP0005646_abnormal_pituitary_gland1.59684822
44MP0005319_abnormal_enzyme/_coenzyme1.58859874
45MP0001905_abnormal_dopamine_level1.56380399
46MP0002736_abnormal_nociception_after1.55753992
47MP0009643_abnormal_urine_homeostasis1.55413692
48MP0008875_abnormal_xenobiotic_pharmacok1.55005968
49MP0005670_abnormal_white_adipose1.54957522
50MP0003879_abnormal_hair_cell1.52918489
51MP0004484_altered_response_of1.51754692
52MP0003705_abnormal_hypodermis_morpholog1.49095940
53MP0000759_abnormal_skeletal_muscle1.47478007
54MP0003011_delayed_dark_adaptation1.46139942
55MP0005451_abnormal_body_composition1.44988687
56MP0001873_stomach_inflammation1.39849879
57MP0005369_muscle_phenotype1.34923377
58MP0001346_abnormal_lacrimal_gland1.33344487
59MP0002876_abnormal_thyroid_physiology1.31210051
60MP0002234_abnormal_pharynx_morphology1.29962015
61MP0001666_abnormal_nutrient_absorption1.29951328
62MP0005666_abnormal_adipose_tissue1.27749526
63MP0005266_abnormal_metabolism1.27168194
64MP0005584_abnormal_enzyme/coenzyme_acti1.25406045
65MP0003828_pulmonary_edema1.25289825
66MP0010329_abnormal_lipoprotein_level1.25219162
67MP0000681_abnormal_thyroid_gland1.25165592
68MP0004233_abnormal_muscle_weight1.24189741
69MP0003567_abnormal_fetal_cardiomyocyte1.23629653
70MP0003191_abnormal_cellular_cholesterol1.23449378
71MP0005623_abnormal_meninges_morphology1.21637751
72MP0003195_calcinosis1.19727407
73MP0010030_abnormal_orbit_morphology1.16461653
74MP0004145_abnormal_muscle_electrophysio1.11668584
75MP0005379_endocrine/exocrine_gland_phen1.11376023
76MP0000343_altered_response_to1.11195154
77MP0004043_abnormal_pH_regulation1.10629676
78MP0004185_abnormal_adipocyte_glucose1.10447801
79MP0004085_abnormal_heartbeat1.10019679
80MP0005636_abnormal_mineral_homeostasis1.09661386
81MP0002148_abnormal_hypersensitivity_rea1.06957513
82MP0003656_abnormal_erythrocyte_physiolo1.05407651
83MP0005165_increased_susceptibility_to1.03969691
84MP0001756_abnormal_urination1.03402643
85MP0004019_abnormal_vitamin_homeostasis1.02985279
86MP0000049_abnormal_middle_ear1.02070509
87MP0005058_abnormal_lysosome_morphology1.01910075
88MP0002638_abnormal_pupillary_reflex1.01208449
89MP0002822_catalepsy1.00970400
90MP0009379_abnormal_foot_pigmentation1.00219538
91MP0002332_abnormal_exercise_endurance0.99990126
92MP0009745_abnormal_behavioral_response0.99224576
93MP0002160_abnormal_reproductive_system0.98345344
94MP0003252_abnormal_bile_duct0.98226017
95MP0008872_abnormal_physiological_respon0.97842407
96MP0002118_abnormal_lipid_homeostasis0.96810919
97MP0001502_abnormal_circadian_rhythm0.96119944
98MP0005671_abnormal_response_to0.95961098
99MP0002733_abnormal_thermal_nociception0.95240879
100MP0002127_abnormal_cardiovascular_syste0.93529704
101MP0004147_increased_porphyrin_level0.90985150
102MP0002064_seizures0.88999853
103MP0000609_abnormal_liver_physiology0.87946476
104MP0003693_abnormal_embryo_hatching0.86653500
105MP0006292_abnormal_olfactory_placode0.86311784
106MP0003315_abnormal_perineum_morphology0.86096008
107MP0009278_abnormal_bone_marrow0.85633477
108MP0000230_abnormal_systemic_arterial0.85163724
109MP0001970_abnormal_pain_threshold0.83655878
110MP0000003_abnormal_adipose_tissue0.81377701
111MP0004510_myositis0.80552512
112MP0001853_heart_inflammation0.80273829
113MP0001188_hyperpigmentation0.79864124
114MP0005084_abnormal_gallbladder_morpholo0.79669463
115MP0001764_abnormal_homeostasis0.79312567
116MP0005423_abnormal_somatic_nervous0.78328583
117MP0000538_abnormal_urinary_bladder0.77428991
118MP0003279_aneurysm0.77174306
119MP0001881_abnormal_mammary_gland0.76937974
120MP0004142_abnormal_muscle_tone0.76674807
121MP0000358_abnormal_cell_content/0.76495997
122MP0002277_abnormal_respiratory_mucosa0.76094698
123MP0003566_abnormal_cell_adhesion0.75054245
124MP0000733_abnormal_muscle_development0.73963363
125MP0010368_abnormal_lymphatic_system0.73949788
126MP0005375_adipose_tissue_phenotype0.73598404
127MP0000266_abnormal_heart_morphology0.73141443
128MP0003075_altered_response_to0.71514784
129MP0005377_hearing/vestibular/ear_phenot0.70256157
130MP0003878_abnormal_ear_physiology0.70256157
131MP0005376_homeostasis/metabolism_phenot0.69756704
132MP0000685_abnormal_immune_system0.68986232
133MP0001765_abnormal_ion_homeostasis0.67956919
134MP0000598_abnormal_liver_morphology0.67674931
135MP0001664_abnormal_digestion0.66879116
136MP0006276_abnormal_autonomic_nervous0.65380180
137MP0004957_abnormal_blastocyst_morpholog0.64979293
138MP0002272_abnormal_nervous_system0.64863887
139MP0002078_abnormal_glucose_homeostasis0.64146889
140MP0009053_abnormal_anal_canal0.60308793
141MP0002136_abnormal_kidney_physiology0.57948030
142MP0009642_abnormal_blood_homeostasis0.57776575
143MP0002796_impaired_skin_barrier0.54499781
144MP0001663_abnormal_digestive_system0.51817360
145MP0008469_abnormal_protein_level0.51496758
146MP0003283_abnormal_digestive_organ0.50671851
147MP0002971_abnormal_brown_adipose0.49532596
148MP0002970_abnormal_white_adipose0.49320863
149MP0002128_abnormal_blood_circulation0.48936363
150MP0000013_abnormal_adipose_tissue0.48845665
151MP0000490_abnormal_crypts_of0.48315276

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)4.94116366
2Hepatic necrosis (HP:0002605)4.81345847
3Abnormal mitochondria in muscle tissue (HP:0008316)4.49272154
4Acute necrotizing encephalopathy (HP:0006965)4.46005686
5Hepatocellular necrosis (HP:0001404)4.45185847
6Ventricular tachycardia (HP:0004756)4.39349938
7Acute encephalopathy (HP:0006846)4.29251496
8Myoglobinuria (HP:0002913)4.19658002
9Mitochondrial inheritance (HP:0001427)4.19656536
10Increased muscle lipid content (HP:0009058)3.92828989
11Increased CSF lactate (HP:0002490)3.86188004
12Muscle fiber inclusion bodies (HP:0100299)3.85212708
13Rhabdomyolysis (HP:0003201)3.80120040
14Palpitations (HP:0001962)3.79514493
15Cerebral edema (HP:0002181)3.71120845
16Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.67726805
17Increased intramyocellular lipid droplets (HP:0012240)3.64560826
18Myopathic facies (HP:0002058)3.63910894
19Dicarboxylic aciduria (HP:0003215)3.63082586
20Abnormality of dicarboxylic acid metabolism (HP:0010995)3.63082586
21Nemaline bodies (HP:0003798)3.62699449
22Exercise-induced muscle cramps (HP:0003710)3.61293332
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.56785105
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.56785105
25Progressive macrocephaly (HP:0004481)3.47177457
26Abnormality of fatty-acid metabolism (HP:0004359)3.46087157
27Calf muscle hypertrophy (HP:0008981)3.45549637
28Lactic acidosis (HP:0003128)3.44919762
29Lipoatrophy (HP:0100578)3.40059520
30Exercise-induced myalgia (HP:0003738)3.39761631
31Muscle fiber splitting (HP:0003555)3.32690126
32Right ventricular cardiomyopathy (HP:0011663)3.27329858
33Hypoglycemic coma (HP:0001325)3.21342098
34Respiratory failure (HP:0002878)3.16039852
35Lipid accumulation in hepatocytes (HP:0006561)3.14881481
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.11541474
37Ragged-red muscle fibers (HP:0003200)3.10085689
38Hyperammonemia (HP:0001987)3.10041423
39Ketoacidosis (HP:0001993)3.09944419
40Generalized aminoaciduria (HP:0002909)3.07460230
41Muscle hypertrophy of the lower extremities (HP:0008968)3.07048200
42Exercise intolerance (HP:0003546)3.01812676
43Increased serum lactate (HP:0002151)2.95350522
44Ketosis (HP:0001946)2.95156032
45Dilated cardiomyopathy (HP:0001644)2.93927398
46Hyperglycinuria (HP:0003108)2.91176276
47Atrial fibrillation (HP:0005110)2.89469775
48Supraventricular tachycardia (HP:0004755)2.85470411
49Lethargy (HP:0001254)2.81784296
50Type 1 muscle fiber predominance (HP:0003803)2.81439654
51Abnormality of the calf musculature (HP:0001430)2.79445850
52Supraventricular arrhythmia (HP:0005115)2.79281217
53Asymmetric septal hypertrophy (HP:0001670)2.76775792
54Primary atrial arrhythmia (HP:0001692)2.75581443
55Subaortic stenosis (HP:0001682)2.74832460
56Abnormality of the left ventricular outflow tract (HP:0011103)2.74832460
57Increased hepatocellular lipid droplets (HP:0006565)2.74604619
58Ventricular fibrillation (HP:0001663)2.73957099
59Type II lissencephaly (HP:0007260)2.66049062
60Conjunctival hamartoma (HP:0100780)2.65567164
61Multiple enchondromatosis (HP:0005701)2.60294446
62Syncope (HP:0001279)2.60146094
63Myotonia (HP:0002486)2.55907615
64Increased serum pyruvate (HP:0003542)2.55726133
65Abnormality of glycolysis (HP:0004366)2.55726133
66Ventricular arrhythmia (HP:0004308)2.53531615
67Hyporeflexia of lower limbs (HP:0002600)2.51274157
68EMG: myopathic abnormalities (HP:0003458)2.50765372
69Nausea (HP:0002018)2.48680478
70Microretrognathia (HP:0000308)2.48151423
71Muscle stiffness (HP:0003552)2.46889559
72Glycosuria (HP:0003076)2.46057941
73Abnormality of urine glucose concentration (HP:0011016)2.46057941
74Abnormality of serine family amino acid metabolism (HP:0010894)2.45910495
75Abnormality of glycine metabolism (HP:0010895)2.45910495
76Distal arthrogryposis (HP:0005684)2.44837987
77Achilles tendon contracture (HP:0001771)2.42633572
78Testicular atrophy (HP:0000029)2.42557951
793-Methylglutaconic aciduria (HP:0003535)2.41289193
80Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.41220447
81Aplasia/Hypoplasia of the sacrum (HP:0008517)2.39107262
82Proximal tubulopathy (HP:0000114)2.38320608
83Increased connective tissue (HP:0009025)2.38054262
84Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.37736661
85Bundle branch block (HP:0011710)2.37454514
86Vomiting (HP:0002013)2.36515519
87Hyperthyroidism (HP:0000836)2.35489477
88Cerebral palsy (HP:0100021)2.34777214
89Abnormality of cells of the erythroid lineage (HP:0012130)2.34024477
90Prolonged QT interval (HP:0001657)2.31338306
91Bulbar palsy (HP:0001283)2.30855127
92Gout (HP:0001997)2.30162061
93Abnormality of aromatic amino acid family metabolism (HP:0004338)2.28064100
94CNS demyelination (HP:0007305)2.27840464
95Centrally nucleated skeletal muscle fibers (HP:0003687)2.27635166
96Metabolic acidosis (HP:0001942)2.27571723
97Esophageal neoplasm (HP:0100751)2.26220092
98Neoplasm of head and neck (HP:0012288)2.26220092
99Atrioventricular block (HP:0001678)2.25302998
100Progressive microcephaly (HP:0000253)2.24961719
101Late onset (HP:0003584)2.24137056
102Abnormal number of erythroid precursors (HP:0012131)2.24115431
103Heart block (HP:0012722)2.20362769
104Difficulty climbing stairs (HP:0003551)2.18839580
105Macrocytic anemia (HP:0001972)2.16131327
106Progressive muscle weakness (HP:0003323)2.16070279
107Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14714428
108Absent phalangeal crease (HP:0006109)2.14028019
109Hyperglycinemia (HP:0002154)2.13969523
110Abnormal atrioventricular conduction (HP:0005150)2.13435454
111Abnormality of the Achilles tendon (HP:0005109)2.13235729
112Type I transferrin isoform profile (HP:0003642)2.08262269
113Renal Fanconi syndrome (HP:0001994)2.05719109
114Round ear (HP:0100830)2.05046099
115Optic disc pallor (HP:0000543)2.04864412
116Opisthotonus (HP:0002179)2.04346181
117Neoplasm of the adrenal gland (HP:0100631)2.03723204
118Severe muscular hypotonia (HP:0006829)2.03592680
119Emotional lability (HP:0000712)2.02707811
120Truncus arteriosus (HP:0001660)1.98147367
121Ulnar deviation of the wrist (HP:0003049)1.98143982
122Abnormal cartilage morphology (HP:0002763)1.95371711
123Exertional dyspnea (HP:0002875)1.95059483
124Reticulocytopenia (HP:0001896)1.93487656
125Respiratory difficulties (HP:0002880)1.92847778
126Hyperphosphaturia (HP:0003109)1.92247419
127Pheochromocytoma (HP:0002666)1.90724359
128Limb-girdle muscle atrophy (HP:0003797)1.90331454
129Concave nail (HP:0001598)1.89957722
130Methylmalonic aciduria (HP:0012120)1.89588136
131Pallor (HP:0000980)1.86556470
132Distal lower limb muscle weakness (HP:0009053)1.84411272
133Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83651000
134Abnormal protein N-linked glycosylation (HP:0012347)1.83651000
135Abnormal protein glycosylation (HP:0012346)1.83651000
136Abnormal glycosylation (HP:0012345)1.83651000
137Hypertensive crisis (HP:0100735)1.81870430
138Broad distal phalanx of finger (HP:0009836)1.79691089
139Myokymia (HP:0002411)1.79267297
140Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78425696
141Cerebellar dysplasia (HP:0007033)1.74807500
142Congenital malformation of the right heart (HP:0011723)1.74559496
143Double outlet right ventricle (HP:0001719)1.74559496
144Calcaneovalgus deformity (HP:0001848)1.72134467
145Leukodystrophy (HP:0002415)1.70854995
146Abnormal rod and cone electroretinograms (HP:0008323)1.68809552
147Generalized muscle weakness (HP:0003324)1.68019552
148Elevated erythrocyte sedimentation rate (HP:0003565)1.67470992
149Mesangial abnormality (HP:0001966)1.66819205
150Muscle fiber atrophy (HP:0100295)1.66368465
151Neck muscle weakness (HP:0000467)1.65539731
152Hyperalaninemia (HP:0003348)1.64887909

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.75548439
2VRK24.13515126
3NME23.74010683
4MYLK3.47556328
5TRIB33.46830291
6PKN23.19013894
7TTN3.01500177
8LMTK22.84172267
9NEK12.65075238
10ERN12.43786122
11OBSCN2.31916322
12KDR2.25383086
13MAP3K112.01508020
14PDK41.99896731
15PDK31.99896731
16PHKG11.99417632
17PHKG21.99417632
18PIM21.96246527
19ILK1.90526722
20MAPKAPK31.87099788
21CDK191.72258722
22TESK21.67691844
23SMG11.62679695
24BUB11.62127828
25NME11.57314449
26ARAF1.50120184
27IRAK31.44604704
28TESK11.43638868
29LRRK21.39421847
30DAPK31.32538173
31WNK41.31881268
32MAP2K31.31797676
33FLT31.26461001
34STK161.25411589
35PIK3CA1.25147615
36MAP2K21.22047424
37TAOK31.17355393
38TAOK11.14007595
39PINK11.13232362
40ZAK1.12484639
41LIMK11.09219949
42PRKD31.07627224
43MUSK1.07532671
44CDK81.04276303
45EIF2AK11.02807721
46EPHB21.02636374
47TIE11.00781417
48MAP3K30.95340052
49VRK10.94173635
50MAP3K100.90921906
51CSNK1G30.90040178
52ADRBK20.89811547
53PDK20.89739503
54STK240.84807127
55IKBKB0.84676048
56PAK40.83690662
57BRAF0.83591846
58DAPK10.82998372
59PRKG20.82714709
60ABL20.82316161
61RPS6KA50.81937550
62MAP2K60.80607503
63MAP3K90.80078273
64DMPK0.79914173
65WEE10.79784681
66MAPKAPK50.79624688
67SCYL20.77374263
68RPS6KB20.77284909
69GRK50.76320223
70MAP4K10.76256349
71RIPK10.72343839
72TAOK20.70986519
73TBK10.70300192
74MAP4K20.67967847
75MAPK110.67367425
76KIT0.66909894
77MAP3K130.66729833
78TLK10.65932392
79MAPK120.65485210
80MAP3K120.65172617
81MAP3K50.64162152
82ZAP700.64054427
83EEF2K0.63620887
84MAP3K70.63338270
85TNK20.63328652
86CCNB10.61277994
87CAMK2D0.60028178
88NUAK10.59880368
89MAP3K80.58103284
90PRKD10.57979567
91PRKD20.57351178
92AKT20.56762651
93PAK10.56165145
94RPS6KL10.55170362
95RPS6KC10.55170362
96AURKA0.52806444
97GRK60.52632660
98DYRK20.52246094
99CHEK20.50890704
100RPS6KA60.50759627
101HIPK20.50687994
102GRK10.49808883
103PTK60.48874428
104ROCK10.47843010
105MAP2K10.46287838
106CSNK1A1L0.46176808
107DAPK20.46064295
108CAMK2B0.45792597
109ADRBK10.45439473
110RPS6KA40.45143642
111MST1R0.45093128
112BLK0.43060474
113BRSK10.42905746
114SIK10.42804851
115AURKB0.42801974
116FGFR40.42772392
117PIK3CG0.42032626
118TAF10.41830353
119MAP3K10.41742467
120KSR20.41678794
121CSNK1G20.41642572
122PAK30.41599013
123CDC70.41522877
124TXK0.41086158
125CAMK2G0.40565721
126IRAK40.40138593
127PDPK10.39663967
128PKN10.38972742
129STK38L0.38608589
130CDC42BPA0.37563916
131CDK11A0.37372950
132CSNK2A10.35659715
133RPS6KA20.33878210
134CSNK1G10.33695894
135CSNK2A20.32496602
136PRKCI0.32247812
137DYRK30.31835162
138STK40.31808446
139MAPK40.31306785
140RPS6KA10.31034191
141PTK2B0.30552000
142MAPKAPK20.29806289
143CAMK10.27359447
144NEK90.27005800
145EIF2AK30.26280827

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.59882480
2* Oxidative phosphorylation_Homo sapiens_hsa001903.89058513
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.83072707
4Parkinsons disease_Homo sapiens_hsa050123.78555295
5Cardiac muscle contraction_Homo sapiens_hsa042602.86345232
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.78603605
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.69248929
8Ribosome_Homo sapiens_hsa030102.67316437
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.65399697
10Propanoate metabolism_Homo sapiens_hsa006402.64654162
11Carbon metabolism_Homo sapiens_hsa012002.60310717
12Fatty acid degradation_Homo sapiens_hsa000712.57530470
13Alzheimers disease_Homo sapiens_hsa050102.52791239
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45809138
15Huntingtons disease_Homo sapiens_hsa050162.42794641
16Pyruvate metabolism_Homo sapiens_hsa006202.13239889
17Biosynthesis of amino acids_Homo sapiens_hsa012301.81062169
18Proteasome_Homo sapiens_hsa030501.80629799
19Butanoate metabolism_Homo sapiens_hsa006501.69077524
20Fatty acid metabolism_Homo sapiens_hsa012121.66760873
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60429411
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.59400368
23Sulfur relay system_Homo sapiens_hsa041221.54561566
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51405448
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45838363
26Tryptophan metabolism_Homo sapiens_hsa003801.42961857
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.41184245
28Homologous recombination_Homo sapiens_hsa034401.37555966
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35406457
30Peroxisome_Homo sapiens_hsa041461.32759189
31Arginine biosynthesis_Homo sapiens_hsa002201.30321825
32Pentose phosphate pathway_Homo sapiens_hsa000301.29973805
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26591965
34Sulfur metabolism_Homo sapiens_hsa009201.24402677
35beta-Alanine metabolism_Homo sapiens_hsa004101.19771921
36PPAR signaling pathway_Homo sapiens_hsa033201.19596945
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.19147742
38Fructose and mannose metabolism_Homo sapiens_hsa000511.19088169
39Galactose metabolism_Homo sapiens_hsa000521.18094758
40Folate biosynthesis_Homo sapiens_hsa007901.17082200
41Primary immunodeficiency_Homo sapiens_hsa053401.15570252
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.14086126
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13767086
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.13722663
45Glutathione metabolism_Homo sapiens_hsa004801.09890260
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.05775856
47Starch and sucrose metabolism_Homo sapiens_hsa005001.04109915
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03413985
49Arginine and proline metabolism_Homo sapiens_hsa003301.02372422
50Phenylalanine metabolism_Homo sapiens_hsa003601.00267945
51Fatty acid elongation_Homo sapiens_hsa000620.97042611
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95498548
53Dilated cardiomyopathy_Homo sapiens_hsa054140.95331648
54Fat digestion and absorption_Homo sapiens_hsa049750.94825307
55Pyrimidine metabolism_Homo sapiens_hsa002400.91638250
56DNA replication_Homo sapiens_hsa030300.91375792
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87889706
58Asthma_Homo sapiens_hsa053100.81702907
59Synaptic vesicle cycle_Homo sapiens_hsa047210.80975588
60Collecting duct acid secretion_Homo sapiens_hsa049660.80016972
61* Metabolic pathways_Homo sapiens_hsa011000.78244414
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72395505
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69492723
64RNA polymerase_Homo sapiens_hsa030200.67180798
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65972984
66Linoleic acid metabolism_Homo sapiens_hsa005910.64053377
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63540371
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63253850
69Selenocompound metabolism_Homo sapiens_hsa004500.63070781
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61075583
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60689836
72Tyrosine metabolism_Homo sapiens_hsa003500.60523688
73Chemical carcinogenesis_Homo sapiens_hsa052040.60419267
74Bile secretion_Homo sapiens_hsa049760.57751169
75Allograft rejection_Homo sapiens_hsa053300.57497194
76Caffeine metabolism_Homo sapiens_hsa002320.56871606
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50840837
78Phototransduction_Homo sapiens_hsa047440.47565204
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47470404
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46238649
81One carbon pool by folate_Homo sapiens_hsa006700.45341443
82Base excision repair_Homo sapiens_hsa034100.44972632
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42916272
84Autoimmune thyroid disease_Homo sapiens_hsa053200.41025490
85Histidine metabolism_Homo sapiens_hsa003400.40713245
86Mismatch repair_Homo sapiens_hsa034300.40474078
87Graft-versus-host disease_Homo sapiens_hsa053320.39220617
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.37480926
89Fanconi anemia pathway_Homo sapiens_hsa034600.33830379
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33327270
91Purine metabolism_Homo sapiens_hsa002300.31561908
92Vitamin B6 metabolism_Homo sapiens_hsa007500.31113293
93Viral myocarditis_Homo sapiens_hsa054160.30248185
94Glycerolipid metabolism_Homo sapiens_hsa005610.30219493
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.29420648
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29361623
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28862294
98Calcium signaling pathway_Homo sapiens_hsa040200.28379919
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28235425
100Vibrio cholerae infection_Homo sapiens_hsa051100.27733672
101Rheumatoid arthritis_Homo sapiens_hsa053230.27419834
102Insulin signaling pathway_Homo sapiens_hsa049100.27250865
103Nitrogen metabolism_Homo sapiens_hsa009100.26965441
104Glucagon signaling pathway_Homo sapiens_hsa049220.26483539
105HIF-1 signaling pathway_Homo sapiens_hsa040660.24293956
106Insulin resistance_Homo sapiens_hsa049310.23311703
107Regulation of autophagy_Homo sapiens_hsa041400.21755752
108Type I diabetes mellitus_Homo sapiens_hsa049400.21692104
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.19756388
110Retinol metabolism_Homo sapiens_hsa008300.19431653
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18709979
112Antigen processing and presentation_Homo sapiens_hsa046120.18697086
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16528200
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.14002663
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.13872664
116Lysine degradation_Homo sapiens_hsa003100.12950758
117Bladder cancer_Homo sapiens_hsa052190.12319964
118Mineral absorption_Homo sapiens_hsa049780.11289077
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11028290
120Thyroid cancer_Homo sapiens_hsa052160.10697197
121AMPK signaling pathway_Homo sapiens_hsa041520.10225475
122Protein export_Homo sapiens_hsa030600.08777197
123Spliceosome_Homo sapiens_hsa030400.08152963
124Arachidonic acid metabolism_Homo sapiens_hsa005900.07763143
125Nucleotide excision repair_Homo sapiens_hsa034200.06068675
126Complement and coagulation cascades_Homo sapiens_hsa046100.03619019
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.03462545
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.0070858

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