ATP5E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the epsilon subunit of the catalytic core. Two pseudogenes of this gene are located on chromosomes 4 and 13. Read-through transcripts that include exons from this gene are expressed from the upstream gene SLMO2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* ATP synthesis coupled proton transport (GO:0015986)9.87760137
2* energy coupled proton transport, down electrochemical gradient (GO:0015985)9.87760137
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.64849478
4* respiratory electron transport chain (GO:0022904)8.70823156
5* electron transport chain (GO:0022900)8.49207472
6ribosomal small subunit biogenesis (GO:0042274)5.63192540
7viral transcription (GO:0019083)5.42489540
8sequestering of actin monomers (GO:0042989)5.29927569
9* ATP biosynthetic process (GO:0006754)5.23990634
10ribosomal large subunit biogenesis (GO:0042273)5.22692126
11translational termination (GO:0006415)5.11912812
12* hydrogen ion transmembrane transport (GO:1902600)5.01207389
13chaperone-mediated protein transport (GO:0072321)4.97983200
14protein neddylation (GO:0045116)4.93815019
15* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.92869755
16* purine nucleoside triphosphate biosynthetic process (GO:0009145)4.84310188
17cotranslational protein targeting to membrane (GO:0006613)4.75809360
18protein targeting to ER (GO:0045047)4.70826404
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.68071960
20protein complex biogenesis (GO:0070271)4.68049547
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.60651870
22mitochondrial respiratory chain complex I assembly (GO:0032981)4.60651870
23NADH dehydrogenase complex assembly (GO:0010257)4.60651870
24establishment of protein localization to mitochondrial membrane (GO:0090151)4.56449527
25establishment of protein localization to endoplasmic reticulum (GO:0072599)4.54815544
26protein localization to endoplasmic reticulum (GO:0070972)4.47475711
27oxidative phosphorylation (GO:0006119)4.46321460
28* proton transport (GO:0015992)4.41535375
29inner mitochondrial membrane organization (GO:0007007)4.35715483
30* hydrogen transport (GO:0006818)4.33673153
31* ribonucleoside triphosphate biosynthetic process (GO:0009201)4.24177641
32nuclear-transcribed mRNA catabolic process (GO:0000956)4.23481164
33mitochondrial respiratory chain complex assembly (GO:0033108)4.19706594
34translational elongation (GO:0006414)4.07635846
35viral life cycle (GO:0019058)4.02453718
36mRNA catabolic process (GO:0006402)3.99769124
37cellular protein complex disassembly (GO:0043624)3.98071196
38GTP biosynthetic process (GO:0006183)3.87058766
39ribosomal small subunit assembly (GO:0000028)3.76406018
40cellular component biogenesis (GO:0044085)3.74733992
41regulation of oxidative phosphorylation (GO:0002082)3.71123225
42proteasome assembly (GO:0043248)3.64844442
43RNA catabolic process (GO:0006401)3.56664625
44* nucleoside triphosphate biosynthetic process (GO:0009142)3.53415520
45central nervous system myelination (GO:0022010)3.48603437
46axon ensheathment in central nervous system (GO:0032291)3.48603437
47ribonucleoprotein complex biogenesis (GO:0022613)3.43286264
48aldehyde catabolic process (GO:0046185)3.41393958
49termination of RNA polymerase III transcription (GO:0006386)3.34900929
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.34900929
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.32874138
52fatty acid elongation (GO:0030497)3.28652313
53substantia nigra development (GO:0021762)3.26149171
54aerobic respiration (GO:0009060)3.24894315
55establishment of protein localization to organelle (GO:0072594)3.24685194
56protein targeting to membrane (GO:0006612)3.21980669
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.21856694
58* mitochondrial transport (GO:0006839)3.19024727
59translational initiation (GO:0006413)3.13617937
60protein complex disassembly (GO:0043241)3.12571384
61* generation of precursor metabolites and energy (GO:0006091)3.10660434
62UTP biosynthetic process (GO:0006228)3.10115016
63translation (GO:0006412)3.09295511
64protein localization to membrane (GO:0072657)3.05837506
65protein-cofactor linkage (GO:0018065)3.03661905
66pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.99201873
67viral protein processing (GO:0019082)2.96360826
68platelet dense granule organization (GO:0060155)2.95443168
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95287548
70macromolecular complex disassembly (GO:0032984)2.94446816
71negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.94068944
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88202794
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88202794
74UTP metabolic process (GO:0046051)2.85781256
75regulation of cellular amino acid metabolic process (GO:0006521)2.84889510
76regulation of cellular respiration (GO:0043457)2.83138224
77spliceosomal complex assembly (GO:0000245)2.82550647
78regulation of mitochondrial translation (GO:0070129)2.81070679
79maturation of SSU-rRNA (GO:0030490)2.80518463
80positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77998230
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.77267749
82DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.77164485
83respiratory chain complex IV assembly (GO:0008535)2.76076738
84tricarboxylic acid cycle (GO:0006099)2.72987700
85intracellular protein transmembrane import (GO:0044743)2.72813078
86protein targeting to mitochondrion (GO:0006626)2.72458821
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.70743665
88establishment of protein localization to mitochondrion (GO:0072655)2.69943207
89creatine metabolic process (GO:0006600)2.69792027
90dopamine transport (GO:0015872)2.68849401
91ATP hydrolysis coupled proton transport (GO:0015991)2.68464533
92energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.68464533
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68184561
94negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.67843657
95negative regulation of ligase activity (GO:0051352)2.67843657
96water-soluble vitamin biosynthetic process (GO:0042364)2.67602811
97cellular ketone body metabolic process (GO:0046950)2.66342262
98antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.65652448
99* purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.65013019
100* purine nucleoside monophosphate biosynthetic process (GO:0009127)2.65013019
101intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.64737392
102signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.64737392
103ubiquinone biosynthetic process (GO:0006744)2.64247631
104quinone biosynthetic process (GO:1901663)2.64247631
105behavioral response to nicotine (GO:0035095)2.63717104
106actin-myosin filament sliding (GO:0033275)2.63574232
107muscle filament sliding (GO:0030049)2.63574232
108cytochrome complex assembly (GO:0017004)2.63378234
109signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.63303409
110signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.63303409
111signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.63303409
112rRNA processing (GO:0006364)2.58645640
113sarcomere organization (GO:0045214)2.58122521
114nucleoside diphosphate phosphorylation (GO:0006165)2.56251965
115negative regulation of protein localization to cell surface (GO:2000009)2.56096692
116protein localization to mitochondrion (GO:0070585)2.55889527
117* purine nucleoside biosynthetic process (GO:0042451)2.55173329
118* purine ribonucleoside biosynthetic process (GO:0046129)2.55173329
119heart process (GO:0003015)2.53762939
120heart contraction (GO:0060047)2.53762939
121ubiquinone metabolic process (GO:0006743)2.53671761
122calcium-mediated signaling using intracellular calcium source (GO:0035584)2.53213490
123sarcoplasmic reticulum calcium ion transport (GO:0070296)2.49942536
124cholesterol biosynthetic process (GO:0006695)2.47505620
125regulation of cell communication by electrical coupling (GO:0010649)2.45426677
126CTP metabolic process (GO:0046036)2.44881809
127CTP biosynthetic process (GO:0006241)2.44881809
128positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.43631040
129guanosine-containing compound biosynthetic process (GO:1901070)2.42541428
130establishment of protein localization to membrane (GO:0090150)2.42214001
131cellular respiration (GO:0045333)2.41950621
132mitochondrion morphogenesis (GO:0070584)2.41557992
133regulation of catecholamine metabolic process (GO:0042069)2.38138772
134regulation of dopamine metabolic process (GO:0042053)2.38138772
135long-chain fatty acid biosynthetic process (GO:0042759)2.38004875
136ketone body metabolic process (GO:1902224)2.36878073
137protein targeting (GO:0006605)2.36567210
138* mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.2486617

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.30454478
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.80742178
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.69028575
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.14875175
5EZH2_22144423_ChIP-Seq_EOC_Human2.86278624
6* MYC_18555785_ChIP-Seq_MESCs_Mouse2.85039691
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82954128
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.79231972
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.77983741
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73503004
11VDR_22108803_ChIP-Seq_LS180_Human2.40916689
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.40916271
13* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.40528503
14* VDR_23849224_ChIP-Seq_CD4+_Human2.35500502
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.30162889
16XRN2_22483619_ChIP-Seq_HELA_Human2.19293292
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.17877349
18TTF2_22483619_ChIP-Seq_HELA_Human2.02289707
19CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.01127352
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96299317
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95196167
22TAF15_26573619_Chip-Seq_HEK293_Human1.91969990
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91424510
24FOXP3_21729870_ChIP-Seq_TREG_Human1.88502344
25* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87496061
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.87298878
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87295949
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83908572
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82628119
30* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77452709
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.76909004
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75986884
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.74402381
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.74168167
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72804840
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69124160
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.62558009
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61313368
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60788182
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.58181955
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57776260
42* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56483772
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55446788
44MYC_18940864_ChIP-ChIP_HL60_Human1.53530784
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53249749
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53079669
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.50683132
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.50563020
49* GABP_19822575_ChIP-Seq_HepG2_Human1.44464260
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43050021
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43015459
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39596489
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.38260221
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38163064
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38086233
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35683259
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35647683
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34032380
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.31705172
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30922771
61TP53_22573176_ChIP-Seq_HFKS_Human1.25479604
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24670217
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23898182
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23665278
65MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23189716
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20457689
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20457689
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19084618
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15891138
70* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15082313
71ERG_20517297_ChIP-Seq_VCAP_Human1.12478916
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12177081
73STAT1_20625510_ChIP-Seq_HELA_Human1.11911640
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.10470990
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10253592
76IRF1_19129219_ChIP-ChIP_H3396_Human1.10116985
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09799763
78GBX2_23144817_ChIP-Seq_PC3_Human1.09624051
79ER_23166858_ChIP-Seq_MCF-7_Human1.08027969
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07962318
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07603316
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07111056
83HTT_18923047_ChIP-ChIP_STHdh_Human1.07035236
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06101319
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05169919
86CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04672607
87ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04644486
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01522167
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00180417
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99312579
91FOXA1_25329375_ChIP-Seq_VCAP_Human0.99297788
92FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99297788
93SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98625981
94TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98244141
95PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97620764
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95871755
97FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95597003
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95098766
99P300_19829295_ChIP-Seq_ESCs_Human0.94795162
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94733388
101NANOG_20526341_ChIP-Seq_ESCs_Human0.93046964
102AR_20517297_ChIP-Seq_VCAP_Human0.92721625
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92274320
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91322617
105TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91079524
106* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89693689
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89541274
108RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89456599
109ERG_21242973_ChIP-ChIP_JURKAT_Human0.89333270
110CTCF_26484167_Chip-Seq_Bcells_Mouse0.89176233
111MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88834467
112POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87050373
113PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86900754
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86858264
115EP300_21415370_ChIP-Seq_HL-1_Mouse0.86286223
116TAF2_19829295_ChIP-Seq_ESCs_Human0.85574448
117ELK1_19687146_ChIP-ChIP_HELA_Human0.85532386
118FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85446384
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85152046
120SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85027350
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84664970
122IKZF1_21737484_ChIP-ChIP_HCT116_Human0.84198469
123NELFA_20434984_ChIP-Seq_ESCs_Mouse0.84121765
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84029875
125PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83843635
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83028875
127GATA3_21878914_ChIP-Seq_MCF-7_Human0.82663950
128EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.82588303
129CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82575689
130SMC3_22415368_ChIP-Seq_MEFs_Mouse0.82106849
131RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.80657188
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80007370
133ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79879146
134EGR1_23403033_ChIP-Seq_LIVER_Mouse0.79286960
135* FUS_26573619_Chip-Seq_HEK293_Human0.78978960
136IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.78786320
137PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78647345
138MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77864143
139DCP1A_22483619_ChIP-Seq_HELA_Human0.77598746
140YY1_22570637_ChIP-Seq_MALME-3M_Human0.76609694
141ELF5_23300383_ChIP-Seq_T47D_Human0.76247809
142CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.75418142
143SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74566274
144KDM5A_27292631_Chip-Seq_BREAST_Human0.74338435
145SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74033977
146RNF2_27304074_Chip-Seq_ESCs_Mouse0.74022658
147NCOR_22424771_ChIP-Seq_293T_Human0.74010136
148ZNF274_21170338_ChIP-Seq_K562_Hela0.73493765
149SOX2_21211035_ChIP-Seq_LN229_Human0.73115186
150GATA3_21867929_ChIP-Seq_TH1_Mouse0.72961429
151IRF8_21731497_ChIP-ChIP_J774_Mouse0.72817857
152CTCF_20526341_ChIP-Seq_ESCs_Human0.71364830
153FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.71011360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.93008553
2MP0009379_abnormal_foot_pigmentation4.22707457
3MP0001529_abnormal_vocalization3.28200156
4MP0003880_abnormal_central_pattern3.03101866
5MP0003646_muscle_fatigue2.90014254
6MP0000751_myopathy2.69749900
7MP0006036_abnormal_mitochondrial_physio2.62525655
8MP0001905_abnormal_dopamine_level2.41227586
9MP0000749_muscle_degeneration2.39667034
10MP0003136_yellow_coat_color2.27319834
11MP0005084_abnormal_gallbladder_morpholo2.25781560
12MP0004036_abnormal_muscle_relaxation2.23804473
13MP0006276_abnormal_autonomic_nervous2.23688824
14MP0004215_abnormal_myocardial_fiber2.14612505
15MP0004145_abnormal_muscle_electrophysio1.97085641
16MP0005330_cardiomyopathy1.91638547
17MP0003195_calcinosis1.83790057
18MP0003123_paternal_imprinting1.79742938
19MP0004084_abnormal_cardiac_muscle1.75337448
20MP0006035_abnormal_mitochondrial_morpho1.75332558
21MP0004043_abnormal_pH_regulation1.65978280
22MP0004142_abnormal_muscle_tone1.65394504
23MP0003137_abnormal_impulse_conducting1.64128727
24MP0005451_abnormal_body_composition1.62985764
25MP0001440_abnormal_grooming_behavior1.61685496
26MP0005671_abnormal_response_to1.61195942
27MP0006292_abnormal_olfactory_placode1.60133280
28MP0003806_abnormal_nucleotide_metabolis1.58846482
29MP0002638_abnormal_pupillary_reflex1.58079311
30MP0002736_abnormal_nociception_after1.53806167
31MP0000920_abnormal_myelination1.50892141
32MP0003787_abnormal_imprinting1.49514231
33MP0003122_maternal_imprinting1.47461865
34MP0002909_abnormal_adrenal_gland1.46666691
35MP0002972_abnormal_cardiac_muscle1.42346856
36MP0008875_abnormal_xenobiotic_pharmacok1.41775624
37MP0000750_abnormal_muscle_regeneration1.41764245
38MP0004381_abnormal_hair_follicle1.41384645
39MP0004019_abnormal_vitamin_homeostasis1.40774250
40MP0002106_abnormal_muscle_physiology1.40065624
41MP0001968_abnormal_touch/_nociception1.39989565
42MP0005645_abnormal_hypothalamus_physiol1.37924760
43MP0005083_abnormal_biliary_tract1.37329157
44MP0004742_abnormal_vestibular_system1.35979144
45MP0002653_abnormal_ependyma_morphology1.35897759
46MP0005620_abnormal_muscle_contractility1.35187707
47MP0003186_abnormal_redox_activity1.35180814
48MP0002272_abnormal_nervous_system1.34419408
49MP0002332_abnormal_exercise_endurance1.31388363
50MP0005379_endocrine/exocrine_gland_phen1.31136423
51MP0000343_altered_response_to1.31051290
52MP0008995_early_reproductive_senescence1.25609972
53MP0005360_urolithiasis1.23923106
54MP0002148_abnormal_hypersensitivity_rea1.22851922
55MP0002822_catalepsy1.21979710
56MP0005535_abnormal_body_temperature1.21219108
57MP0001919_abnormal_reproductive_system1.20389020
58MP0001727_abnormal_embryo_implantation1.20183758
59MP0005646_abnormal_pituitary_gland1.19806525
60MP0003011_delayed_dark_adaptation1.18562146
61MP0005085_abnormal_gallbladder_physiolo1.17749594
62MP0005332_abnormal_amino_acid1.17637537
63MP0001485_abnormal_pinna_reflex1.17237603
64MP0002163_abnormal_gland_morphology1.15786437
65MP0009745_abnormal_behavioral_response1.14427311
66MP0005369_muscle_phenotype1.14381542
67MP0006072_abnormal_retinal_apoptosis1.14325707
68MP0002095_abnormal_skin_pigmentation1.12531197
69MP0002064_seizures1.12306836
70MP0004484_altered_response_of1.11816462
71MP0005409_darkened_coat_color1.11782242
72MP0003121_genomic_imprinting1.11470450
73MP0008872_abnormal_physiological_respon1.11037018
74MP0004147_increased_porphyrin_level1.10676677
75MP0001970_abnormal_pain_threshold1.09175869
76MP0003638_abnormal_response/metabolism_1.08185158
77MP0001756_abnormal_urination1.07631462
78MP0005636_abnormal_mineral_homeostasis1.07549334
79MP0002938_white_spotting1.07332247
80MP0004085_abnormal_heartbeat1.05795722
81MP0002132_abnormal_respiratory_system1.05477149
82MP0000747_muscle_weakness1.05372315
83MP0003950_abnormal_plasma_membrane1.04453466
84MP0002693_abnormal_pancreas_physiology1.04420145
85MP0000631_abnormal_neuroendocrine_gland1.03702545
86MP0003879_abnormal_hair_cell1.03099218
87MP0005075_abnormal_melanosome_morpholog1.02933056
88MP0009785_altered_susceptibility_to1.02776886
89MP0002734_abnormal_mechanical_nocicepti1.02312601
90MP0010386_abnormal_urinary_bladder1.01903837
91MP0005389_reproductive_system_phenotype1.01826370
92MP0002735_abnormal_chemical_nociception1.01698929
93MP0000372_irregular_coat_pigmentation1.00798111
94MP0001544_abnormal_cardiovascular_syste1.00694740
95MP0005385_cardiovascular_system_phenoty1.00694740
96MP0000013_abnormal_adipose_tissue1.00637013
97MP0004087_abnormal_muscle_fiber1.00497833
98MP0008775_abnormal_heart_ventricle1.00361761
99MP0005386_behavior/neurological_phenoty1.00035891
100MP0004924_abnormal_behavior1.00035891
101MP0002139_abnormal_hepatobiliary_system0.99200235
102MP0002572_abnormal_emotion/affect_behav0.98671839
103MP0002733_abnormal_thermal_nociception0.98230778
104MP0004270_analgesia0.97119932
105MP0005253_abnormal_eye_physiology0.97027840
106MP0006082_CNS_inflammation0.96586966
107MP0009764_decreased_sensitivity_to0.96240235
108MP0001764_abnormal_homeostasis0.94492118
109MP0005165_increased_susceptibility_to0.94019871
110MP0000759_abnormal_skeletal_muscle0.93204486
111MP0001486_abnormal_startle_reflex0.92818113
112MP0004133_heterotaxia0.89841858
113MP0001835_abnormal_antigen_presentation0.89667397
114MP0002160_abnormal_reproductive_system0.88914776
115MP0002557_abnormal_social/conspecific_i0.87603139
116MP0001984_abnormal_olfaction0.87334978
117MP0002067_abnormal_sensory_capabilities0.87092903
118MP0001944_abnormal_pancreas_morphology0.87041098
119MP0000230_abnormal_systemic_arterial0.86627316
120MP0003329_amyloid_beta_deposits0.85858454
121MP0005551_abnormal_eye_electrophysiolog0.84134518
122MP0002876_abnormal_thyroid_physiology0.84067385
123MP0004130_abnormal_muscle_cell0.84016137
124MP0005171_absent_coat_pigmentation0.83665585
125MP0005408_hypopigmentation0.83521193
126MP0005058_abnormal_lysosome_morphology0.83466281
127MP0002102_abnormal_ear_morphology0.81970228
128MP0005195_abnormal_posterior_eye0.81736730
129MP0001501_abnormal_sleep_pattern0.79874694
130MP0002295_abnormal_pulmonary_circulatio0.79654742
131MP0005584_abnormal_enzyme/coenzyme_acti0.77959416
132MP0006138_congestive_heart_failure0.77924463
133MP0000538_abnormal_urinary_bladder0.77691634
134MP0009046_muscle_twitch0.77478457
135MP0005423_abnormal_somatic_nervous0.77312841
136MP0002928_abnormal_bile_duct0.77284899
137MP0002090_abnormal_vision0.76643027
138MP0000026_abnormal_inner_ear0.76321057
139MP0005266_abnormal_metabolism0.75969117
140MP0008789_abnormal_olfactory_epithelium0.75321300
141MP0000778_abnormal_nervous_system0.75297529
142MP0003878_abnormal_ear_physiology0.74338237
143MP0005377_hearing/vestibular/ear_phenot0.74338237
144MP0005174_abnormal_tail_pigmentation0.74133121
145MP0003315_abnormal_perineum_morphology0.72991109
146MP0002277_abnormal_respiratory_mucosa0.72932201
147MP0001663_abnormal_digestive_system0.70923461
148MP0003690_abnormal_glial_cell0.70798134
149MP0003724_increased_susceptibility_to0.70414088
150MP0001853_heart_inflammation0.69359420
151MP0009643_abnormal_urine_homeostasis0.69177726
152MP0005448_abnormal_energy_balance0.68321357

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.66474313
2Abnormal mitochondria in muscle tissue (HP:0008316)6.95270060
3Acute encephalopathy (HP:0006846)6.56423875
4Mitochondrial inheritance (HP:0001427)6.51548510
5Progressive macrocephaly (HP:0004481)6.49415266
6Increased CSF lactate (HP:0002490)5.44755561
7Hepatocellular necrosis (HP:0001404)5.41781518
8Increased hepatocellular lipid droplets (HP:0006565)5.28623315
9Hepatic necrosis (HP:0002605)5.09591999
10Lipid accumulation in hepatocytes (HP:0006561)4.98939280
11Cerebral edema (HP:0002181)4.95609824
12Renal Fanconi syndrome (HP:0001994)4.80106731
13Increased intramyocellular lipid droplets (HP:0012240)4.45762791
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.30919687
15Increased muscle lipid content (HP:0009058)4.09274517
16Optic disc pallor (HP:0000543)3.99434264
17Exercise intolerance (HP:0003546)3.97838621
18Respiratory failure (HP:0002878)3.91738082
19Leukodystrophy (HP:0002415)3.81727473
20Increased serum pyruvate (HP:0003542)3.79979162
21Abnormality of glycolysis (HP:0004366)3.79979162
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.76439299
23* Lactic acidosis (HP:0003128)3.60973143
24Congenital, generalized hypertrichosis (HP:0004540)3.60000745
25Abnormality of cells of the erythroid lineage (HP:0012130)3.51862126
26Muscle hypertrophy of the lower extremities (HP:0008968)3.42338648
27Exertional dyspnea (HP:0002875)3.41705824
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.41045658
29Calf muscle hypertrophy (HP:0008981)3.23899157
30Abnormality of renal resorption (HP:0011038)3.22295855
31Increased serum lactate (HP:0002151)3.06254299
32Parakeratosis (HP:0001036)3.05019591
33Abnormal number of erythroid precursors (HP:0012131)2.98714807
34Glycosuria (HP:0003076)2.89252741
35Abnormality of urine glucose concentration (HP:0011016)2.89252741
36Sudden death (HP:0001699)2.88582909
37Respiratory difficulties (HP:0002880)2.85406369
38Lethargy (HP:0001254)2.68482542
39Hyperphosphaturia (HP:0003109)2.67374133
40X-linked dominant inheritance (HP:0001423)2.66476858
41Macrocytic anemia (HP:0001972)2.60270452
42Exercise-induced myalgia (HP:0003738)2.54524122
43Neuroendocrine neoplasm (HP:0100634)2.50499716
44Pheochromocytoma (HP:0002666)2.50452996
45Congenital ichthyosiform erythroderma (HP:0007431)2.47471692
46Abnormality of midbrain morphology (HP:0002418)2.46235037
47Molar tooth sign on MRI (HP:0002419)2.46235037
48Aplastic anemia (HP:0001915)2.39569982
49CNS demyelination (HP:0007305)2.38152346
50Abnormal urine phosphate concentration (HP:0012599)2.32303113
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.32099927
52Palpitations (HP:0001962)2.31981007
53Conjunctival hamartoma (HP:0100780)2.30664759
54* 3-Methylglutaconic aciduria (HP:0003535)2.25700211
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.24570100
56Dicarboxylic aciduria (HP:0003215)2.24570100
57Concave nail (HP:0001598)2.23790590
58Muscle fiber splitting (HP:0003555)2.19452353
59Myoglobinuria (HP:0002913)2.17962144
60Vomiting (HP:0002013)2.17941511
61Cerebral hemorrhage (HP:0001342)2.15538926
62Reticulocytopenia (HP:0001896)2.11310623
63* Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.10219715
64* Decreased activity of mitochondrial respiratory chain (HP:0008972)2.10219715
65Limb dystonia (HP:0002451)2.08494354
66Muscle stiffness (HP:0003552)2.06932875
67Type I transferrin isoform profile (HP:0003642)2.05574262
68Myotonia (HP:0002486)2.04457456
69Abnormality of the calf musculature (HP:0001430)2.03638362
70Emotional lability (HP:0000712)2.01001624
71Generalized aminoaciduria (HP:0002909)2.00279759
72Ventricular tachycardia (HP:0004756)2.00121001
73Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97803393
74Rhabdomyolysis (HP:0003201)1.97622686
75Ketoacidosis (HP:0001993)1.97609048
76Exercise-induced muscle cramps (HP:0003710)1.93388532
77Abnormal respiratory motile cilium physiology (HP:0012261)1.93247389
78Abnormal pupillary function (HP:0007686)1.90562202
79Sensory axonal neuropathy (HP:0003390)1.88968916
80Medial flaring of the eyebrow (HP:0010747)1.88361211
81Neoplasm of head and neck (HP:0012288)1.87979315
82Esophageal neoplasm (HP:0100751)1.87979315
83Methylmalonic aciduria (HP:0012120)1.87791835
84Pallor (HP:0000980)1.86964588
85Pancreatic cysts (HP:0001737)1.86373121
86Agitation (HP:0000713)1.85978505
87Renal tubular dysfunction (HP:0000124)1.84424897
88Abnormality of fatty-acid metabolism (HP:0004359)1.82789871
89Oral leukoplakia (HP:0002745)1.81207261
90Methylmalonic acidemia (HP:0002912)1.80996875
91Abnormality of alanine metabolism (HP:0010916)1.80599542
92Hyperalaninemia (HP:0003348)1.80599542
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80599542
94Pancreatic fibrosis (HP:0100732)1.80341525
95Abnormality of placental membranes (HP:0011409)1.80179857
96Amniotic constriction ring (HP:0009775)1.80179857
97Nausea (HP:0002018)1.78917188
98Myokymia (HP:0002411)1.78082195
99Abnormal respiratory motile cilium morphology (HP:0005938)1.77678372
100Abnormal respiratory epithelium morphology (HP:0012253)1.77678372
101Ketosis (HP:0001946)1.75603383
102Abnormal hemoglobin (HP:0011902)1.75086363
103Blindness (HP:0000618)1.74228081
104Abnormal ciliary motility (HP:0012262)1.73017658
105Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70838545
106Vacuolated lymphocytes (HP:0001922)1.69794756
107Hyperthyroidism (HP:0000836)1.69498610
108Prolonged QT interval (HP:0001657)1.69208090
109Muscle fiber inclusion bodies (HP:0100299)1.68776963
110Abnormality of liposaccharide metabolism (HP:0010968)1.67841513
111Abnormality of glycosphingolipid metabolism (HP:0004343)1.67841513
112Abnormality of glycolipid metabolism (HP:0010969)1.67841513
113Polyphagia (HP:0002591)1.65596314
114Lipoatrophy (HP:0100578)1.65327781
115True hermaphroditism (HP:0010459)1.64252058
116EMG: myopathic abnormalities (HP:0003458)1.63974336
117Hypothermia (HP:0002045)1.63580548
118Congenital malformation of the right heart (HP:0011723)1.63513824
119Double outlet right ventricle (HP:0001719)1.63513824
120Nephronophthisis (HP:0000090)1.62940300
121Syncope (HP:0001279)1.62507599
122Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.61751966
123Abnormality of the axillary hair (HP:0100134)1.59992134
124Abnormality of secondary sexual hair (HP:0009888)1.59992134
125Hypoglycemic coma (HP:0001325)1.58662824
126Absent rod-and cone-mediated responses on ERG (HP:0007688)1.58045945
127Poor suck (HP:0002033)1.57686368
128Depressed nasal ridge (HP:0000457)1.57596794
129Hyporeflexia of lower limbs (HP:0002600)1.57467265
130Metabolic acidosis (HP:0001942)1.57439285
131Nemaline bodies (HP:0003798)1.57246193
132Gliosis (HP:0002171)1.56759170
133Sclerocornea (HP:0000647)1.54459283
134Neurofibrillary tangles (HP:0002185)1.54266522
135Absent thumb (HP:0009777)1.53951906
136Abnormality of the anterior horn cell (HP:0006802)1.53767207
137Degeneration of anterior horn cells (HP:0002398)1.53767207
138Testicular atrophy (HP:0000029)1.53350557
139Petechiae (HP:0000967)1.52843154
140Dynein arm defect of respiratory motile cilia (HP:0012255)1.49448030

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.82106394
2VRK23.64112021
3NME13.50497028
4STK393.15852581
5MYLK2.75578845
6OBSCN2.69214162
7WNK42.60930083
8GRK72.40987522
9PBK2.28576065
10MST42.25722353
11OXSR12.09850291
12ARAF2.09681173
13MUSK2.08235452
14STK162.07024324
15BCKDK1.98949364
16PHKG11.90894757
17PHKG21.90894757
18CASK1.84815403
19MAP3K121.77432689
20LIMK11.76082088
21TNIK1.74683276
22TESK11.73277775
23PNCK1.68758479
24MAPK151.61789514
25ZAK1.61614516
26PKN11.61153493
27GRK51.60817352
28MAP3K111.49553811
29UHMK11.44758767
30EIF2AK11.41899833
31DYRK31.39752986
32BCR1.29597102
33ADRBK21.27035018
34CAMK2D1.23350940
35PIK3CG1.21127303
36BUB11.20397494
37IRAK21.18986436
38TTN1.18059930
39TLK11.17032309
40ABL21.16929646
41BMPR1B1.16209713
42CAMK2B1.13021361
43FGR1.10974508
44DYRK21.09894884
45VRK11.08568945
46MAPKAPK51.07549741
47PIM21.06659692
48ILK1.06462061
49CDK191.04157756
50WNK31.03345162
51CAMK2A1.02985408
52MST1R1.02382616
53RIPK41.02009736
54MAP4K21.00889937
55ADRBK11.00425088
56ROCK20.98912412
57MARK10.95422957
58INSRR0.94391012
59CAMK2G0.93577288
60DAPK30.93066128
61BMPR20.92464365
62PIK3CA0.91157256
63MAPK130.87024326
64MAP2K20.84937553
65TXK0.84921046
66TAOK30.84300027
67IKBKB0.83888807
68PINK10.83269697
69TIE10.83244045
70CAMKK20.81376156
71EPHB10.80957651
72AURKA0.79425945
73CSNK1G30.77155301
74PRKCE0.76310633
75PDK40.76280800
76PDK30.76280800
77CDC70.75647005
78PRKACA0.74973615
79PASK0.74750786
80LMTK20.73448541
81BRAF0.73093432
82PAK30.71697412
83MAP3K40.71481234
84MINK10.69795040
85MAPK120.67534227
86FES0.66246964
87CSNK2A10.66171705
88MAP2K60.65873948
89WEE10.64633558
90PRKCQ0.63001470
91MAP2K40.62253221
92AURKB0.61276218
93EPHB20.60872864
94CDK80.58070271
95RPS6KB20.58051785
96LRRK20.57856031
97IRAK10.57596279
98KDR0.56298423
99LYN0.55737830
100EPHA40.55276667
101MAPK40.54903706
102GRK60.54898191
103PDK20.54867398
104SRPK10.54234081
105BLK0.51335476
106PTK2B0.50601845
107MAP2K70.48769933
108PRKD10.48169181
109RPS6KA50.47538723
110SCYL20.45392872
111ROCK10.45305692
112GRK10.44791212
113PRKCI0.44217525
114MARK30.43841530
115MATK0.42504319
116DYRK1B0.42360717
117CSNK1G20.41634365
118PAK10.41490177
119STK240.40008235
120MET0.39456130
121CSNK1G10.39300696
122PAK40.38984154
123CCNB10.37175594
124PRKG10.36955848
125DAPK10.36677881
126IRAK40.35755287
127TESK20.35083017
128SYK0.34629114
129TAF10.34347986
130CDK140.34287475
131EIF2AK30.34251071
132PRKCG0.33290149
133NTRK30.33082960
134PRKCD0.32282185
135PRKCA0.31540544
136PRKACG0.30469337
137CSNK2A20.30370458
138NTRK20.29544249

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.67387758
2Parkinsons disease_Homo sapiens_hsa050125.67307515
3Alzheimers disease_Homo sapiens_hsa050104.46583907
4Ribosome_Homo sapiens_hsa030104.03005585
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.95311933
6Huntingtons disease_Homo sapiens_hsa050163.88640704
7Cardiac muscle contraction_Homo sapiens_hsa042603.29630226
8Proteasome_Homo sapiens_hsa030502.38628609
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36256412
10Fatty acid elongation_Homo sapiens_hsa000622.33633631
11Protein export_Homo sapiens_hsa030602.26364289
12Sulfur metabolism_Homo sapiens_hsa009201.88209626
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.87738467
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74732153
15Propanoate metabolism_Homo sapiens_hsa006401.71719840
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55202357
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45471213
18Butanoate metabolism_Homo sapiens_hsa006501.38830313
19Pyruvate metabolism_Homo sapiens_hsa006201.29776627
20RNA polymerase_Homo sapiens_hsa030201.27901158
21Collecting duct acid secretion_Homo sapiens_hsa049661.27856515
22Homologous recombination_Homo sapiens_hsa034401.16765521
23Steroid biosynthesis_Homo sapiens_hsa001001.16550746
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12643464
25Fatty acid degradation_Homo sapiens_hsa000711.08042873
26Phenylalanine metabolism_Homo sapiens_hsa003601.05288499
27Tyrosine metabolism_Homo sapiens_hsa003501.04154121
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03493270
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00704455
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96975706
31Peroxisome_Homo sapiens_hsa041460.94285122
32Nucleotide excision repair_Homo sapiens_hsa034200.94284259
33Mismatch repair_Homo sapiens_hsa034300.94222665
34Intestinal immune network for IgA production_Homo sapiens_hsa046720.94168336
35Fatty acid metabolism_Homo sapiens_hsa012120.92505430
36Spliceosome_Homo sapiens_hsa030400.91396536
37* Metabolic pathways_Homo sapiens_hsa011000.88205138
38Carbon metabolism_Homo sapiens_hsa012000.85960688
39Histidine metabolism_Homo sapiens_hsa003400.84030183
40Linoleic acid metabolism_Homo sapiens_hsa005910.81217293
41Type I diabetes mellitus_Homo sapiens_hsa049400.81208811
42Glutathione metabolism_Homo sapiens_hsa004800.80791386
43Ether lipid metabolism_Homo sapiens_hsa005650.79797089
44Vibrio cholerae infection_Homo sapiens_hsa051100.79258916
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74909649
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74828987
47Basal transcription factors_Homo sapiens_hsa030220.74442936
48Arginine and proline metabolism_Homo sapiens_hsa003300.71610527
49Tryptophan metabolism_Homo sapiens_hsa003800.67969076
50Chemical carcinogenesis_Homo sapiens_hsa052040.67278781
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66528368
52Sulfur relay system_Homo sapiens_hsa041220.65514748
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64351657
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.63594175
55Regulation of autophagy_Homo sapiens_hsa041400.63030424
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63028336
57Arachidonic acid metabolism_Homo sapiens_hsa005900.62501293
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62002625
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60837689
60Systemic lupus erythematosus_Homo sapiens_hsa053220.59779669
61RNA degradation_Homo sapiens_hsa030180.58776190
62DNA replication_Homo sapiens_hsa030300.58721244
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58533455
64beta-Alanine metabolism_Homo sapiens_hsa004100.57173293
65Synaptic vesicle cycle_Homo sapiens_hsa047210.54850309
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54569558
67Rheumatoid arthritis_Homo sapiens_hsa053230.54461464
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52973139
69PPAR signaling pathway_Homo sapiens_hsa033200.52500658
70Serotonergic synapse_Homo sapiens_hsa047260.51939480
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.51292871
72Folate biosynthesis_Homo sapiens_hsa007900.48626252
73Pyrimidine metabolism_Homo sapiens_hsa002400.46673836
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46060209
75Antigen processing and presentation_Homo sapiens_hsa046120.45510662
76Mineral absorption_Homo sapiens_hsa049780.43048237
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.42456218
78Dilated cardiomyopathy_Homo sapiens_hsa054140.41716725
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39837217
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.39811978
81Graft-versus-host disease_Homo sapiens_hsa053320.39442650
82Fat digestion and absorption_Homo sapiens_hsa049750.38976386
83Nitrogen metabolism_Homo sapiens_hsa009100.37863137
84Phototransduction_Homo sapiens_hsa047440.32871949
85Staphylococcus aureus infection_Homo sapiens_hsa051500.32800133
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32450471
87Fanconi anemia pathway_Homo sapiens_hsa034600.32302359
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32145362
89Nicotine addiction_Homo sapiens_hsa050330.31307970
90Taste transduction_Homo sapiens_hsa047420.28935190
91Retinol metabolism_Homo sapiens_hsa008300.28218560
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27667650
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27587713
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26252297
95Phagosome_Homo sapiens_hsa041450.26081274
96One carbon pool by folate_Homo sapiens_hsa006700.25175727
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24429864
98Sphingolipid metabolism_Homo sapiens_hsa006000.24277921
99Asthma_Homo sapiens_hsa053100.24213198
100Lysosome_Homo sapiens_hsa041420.23730419
101Primary immunodeficiency_Homo sapiens_hsa053400.23592706
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23490219
103Caffeine metabolism_Homo sapiens_hsa002320.22226646
104Starch and sucrose metabolism_Homo sapiens_hsa005000.22183918
105Autoimmune thyroid disease_Homo sapiens_hsa053200.21654120
106Purine metabolism_Homo sapiens_hsa002300.21242458
107Base excision repair_Homo sapiens_hsa034100.20242280
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20237463
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19958549
110GABAergic synapse_Homo sapiens_hsa047270.19762367
111Hematopoietic cell lineage_Homo sapiens_hsa046400.19745186
112Vitamin digestion and absorption_Homo sapiens_hsa049770.19589976
113Alcoholism_Homo sapiens_hsa050340.19095923
114Calcium signaling pathway_Homo sapiens_hsa040200.18657653
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18232595
116Allograft rejection_Homo sapiens_hsa053300.16598800
117Epstein-Barr virus infection_Homo sapiens_hsa051690.16183173
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15411802
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.15346780
120Olfactory transduction_Homo sapiens_hsa047400.12596229
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12148036
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11854770
123Renin secretion_Homo sapiens_hsa049240.11709245
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.11695128
125Glutamatergic synapse_Homo sapiens_hsa047240.11465699
126African trypanosomiasis_Homo sapiens_hsa051430.11143117
127Pancreatic secretion_Homo sapiens_hsa049720.11007399
128Salmonella infection_Homo sapiens_hsa051320.10673438
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.10333690
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.10149163
131Prion diseases_Homo sapiens_hsa050200.06799721
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.06294298
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.05878479
134Arginine biosynthesis_Homo sapiens_hsa002200.05399701
135Cocaine addiction_Homo sapiens_hsa050300.02836950
136Morphine addiction_Homo sapiens_hsa050320.02222614

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