ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.99960282
2	chaperone-mediated protein transport (GO:0072321)	5.82672246
3	* energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.77948368
4	* ATP synthesis coupled proton transport (GO:0015986)	5.77948368
5	protein neddylation (GO:0045116)	5.35516239
6	DNA deamination (GO:0045006)	5.25736203
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.23632783
8	respiratory electron transport chain (GO:0022904)	4.80319306
9	electron transport chain (GO:0022900)	4.77761343
10	viral transcription (GO:0019083)	4.67333321
11	protein complex biogenesis (GO:0070271)	4.66578112
12	ribosomal small subunit biogenesis (GO:0042274)	4.60484147
13	translational termination (GO:0006415)	4.53183332
14	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.50815367
15	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.48178883
16	NADH dehydrogenase complex assembly (GO:0010257)	4.48178883
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.48178883
18	ribosomal small subunit assembly (GO:0000028)	4.45380699
19	mitochondrial respiratory chain complex assembly (GO:0033108)	4.28568960
20	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.20346436
21	cotranslational protein targeting to membrane (GO:0006613)	4.14294252
22	protein targeting to ER (GO:0045047)	4.12658758
23	translational elongation (GO:0006414)	4.05081087
24	protein localization to endoplasmic reticulum (GO:0070972)	3.95955173
25	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.93828212
26	behavioral response to nicotine (GO:0035095)	3.93431958
27	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.88482274
28	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.86753086
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.81574176
30	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.81574176
31	water-soluble vitamin biosynthetic process (GO:0042364)	3.75051035
32	maturation of SSU-rRNA (GO:0030490)	3.73381762
33	GTP biosynthetic process (GO:0006183)	3.63973516
34	respiratory chain complex IV assembly (GO:0008535)	3.53027724
35	* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.48891857
36	* hydrogen ion transmembrane transport (GO:1902600)	3.47871976
37	* purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.47122306
38	response to pheromone (GO:0019236)	3.47113955
39	viral life cycle (GO:0019058)	3.45171102
40	* ATP biosynthetic process (GO:0006754)	3.44000508
41	cytochrome complex assembly (GO:0017004)	3.40867118
42	cellular protein complex disassembly (GO:0043624)	3.36647868
43	translation (GO:0006412)	3.36310294
44	protein-cofactor linkage (GO:0018065)	3.26049262
45	* proton transport (GO:0015992)	3.25933256
46	* hydrogen transport (GO:0006818)	3.20531330
47	preassembly of GPI anchor in ER membrane (GO:0016254)	3.16855568
48	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.15631416
49	endoderm formation (GO:0001706)	3.14246520
50	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.12561540
51	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.10289647
52	termination of RNA polymerase III transcription (GO:0006386)	3.10289647
53	platelet dense granule organization (GO:0060155)	3.10099046
54	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.02838540
55	translational initiation (GO:0006413)	3.01303472
56	positive regulation of prostaglandin secretion (GO:0032308)	2.96549657
57	cellular component biogenesis (GO:0044085)	2.95654155
58	* ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.94191149
59	intracellular protein transmembrane import (GO:0044743)	2.93165132
60	UTP biosynthetic process (GO:0006228)	2.90636239
61	base-excision repair, AP site formation (GO:0006285)	2.86251176
62	interferon-gamma production (GO:0032609)	2.84954263
63	positive regulation of fatty acid transport (GO:2000193)	2.78611679
64	ribosomal large subunit biogenesis (GO:0042273)	2.78566656
65	cytidine deamination (GO:0009972)	2.78388778
66	cytidine metabolic process (GO:0046087)	2.78388778
67	cytidine catabolic process (GO:0006216)	2.78388778
68	protein deneddylation (GO:0000338)	2.77989023
69	protein targeting to mitochondrion (GO:0006626)	2.77124343
70	negative regulation of T cell differentiation in thymus (GO:0033085)	2.76747722
71	UTP metabolic process (GO:0046051)	2.73545445
72	establishment of protein localization to mitochondrion (GO:0072655)	2.73313380
73	regulation of cilium movement (GO:0003352)	2.72752081
74	protein complex disassembly (GO:0043241)	2.71265163
75	protein targeting to membrane (GO:0006612)	2.70324594
76	GPI anchor metabolic process (GO:0006505)	2.68103905
77	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.66804172
78	positive regulation of icosanoid secretion (GO:0032305)	2.66502783
79	tRNA processing (GO:0008033)	2.64816940
80	negative regulation of heart rate (GO:0010459)	2.63770309
81	positive regulation of protein homodimerization activity (GO:0090073)	2.63681359
82	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.61489982
83	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.61384507
84	peptidyl-histidine modification (GO:0018202)	2.59214733
85	macromolecular complex disassembly (GO:0032984)	2.58950826
86	guanosine-containing compound biosynthetic process (GO:1901070)	2.58335604
87	* nucleoside triphosphate biosynthetic process (GO:0009142)	2.58006589
88	protein localization to mitochondrion (GO:0070585)	2.57419727
89	negative regulation of mast cell activation (GO:0033004)	2.55174104
90	GPI anchor biosynthetic process (GO:0006506)	2.54151655
91	L-fucose metabolic process (GO:0042354)	2.53653548
92	L-fucose catabolic process (GO:0042355)	2.53653548
93	fucose catabolic process (GO:0019317)	2.53653548
94	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.50680670
95	oxidative phosphorylation (GO:0006119)	2.49516677
96	cellular ketone body metabolic process (GO:0046950)	2.49435352
97	pyrimidine nucleotide catabolic process (GO:0006244)	2.49370330
98	pseudouridine synthesis (GO:0001522)	2.48933815
99	parturition (GO:0007567)	2.48266488
100	mannosylation (GO:0097502)	2.47451591

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.23549356
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.00597969
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.83391215
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.25582943
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.16943092
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.10927366
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.91659563
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.63504044
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.61542340
10	VDR_22108803_ChIP-Seq_LS180_Human	2.54034854
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.46814940
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.39062979
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.37517391
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.29475560
15	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.16986592
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.12621858
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.09061709
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.01690450
19	ELK1_19687146_ChIP-ChIP_HELA_Human	1.99747035
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.94807696
21	MYC_18940864_ChIP-ChIP_HL60_Human	1.85304593
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.83168634
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.82012502
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.79924145
25	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.72596651
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.69326413
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.65646318
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64701019
29	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.60658458
30	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.58871513
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.56599994
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.56466980
33	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.46856845
34	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.37185665
35	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36510953
36	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36510953
37	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.34950705
38	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.34388833
39	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.33520142
40	TAF2_19829295_ChIP-Seq_ESCs_Human	1.31899402
41	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30897530
42	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.29964936
43	GABP_19822575_ChIP-Seq_HepG2_Human	1.29311043
44	TTF2_22483619_ChIP-Seq_HELA_Human	1.29020214
45	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.28592390
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26034875
47	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25383722
48	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.25073800
49	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.25013121
50	NANOG_20526341_ChIP-Seq_ESCs_Human	1.22188336
51	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.21454554
52	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.18313793
53	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.18162709
54	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.17949891
55	* AR_20517297_ChIP-Seq_VCAP_Human	1.17933668
56	* EWS_26573619_Chip-Seq_HEK293_Human	1.17028221
57	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.15137271
58	MYC_19829295_ChIP-Seq_ESCs_Human	1.15011714
59	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.13811426
60	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13041934
61	ERA_21632823_ChIP-Seq_H3396_Human	1.13034961
62	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.12607509
63	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.12013512
64	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.09434877
65	XRN2_22483619_ChIP-Seq_HELA_Human	1.08007477
66	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.07067348
67	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06978231
68	* NCOR_22424771_ChIP-Seq_293T_Human	1.06642895
69	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.04830551
70	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.04660942
71	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.04520148
72	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.04238207
73	* EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.03711303
74	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03270357
75	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02106245
76	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02106245
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01358270
78	HTT_18923047_ChIP-ChIP_STHdh_Human	1.00456665
79	P53_21459846_ChIP-Seq_SAOS-2_Human	1.00415072
80	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.00022473
81	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.99722605
82	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.99421455
83	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99307472
84	BCL6_27268052_Chip-Seq_Bcells_Human	0.98876766
85	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.97717312
86	REST_21632747_ChIP-Seq_MESCs_Mouse	0.94377773
87	FUS_26573619_Chip-Seq_HEK293_Human	0.93270644
88	ERG_20517297_ChIP-Seq_VCAP_Human	0.93230565
89	STAT1_20625510_ChIP-Seq_HELA_Human	0.93179120
90	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.93037828
91	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.92460338
92	P300_19829295_ChIP-Seq_ESCs_Human	0.92456769
93	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.92241655
94	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.90817314
95	RNF2_27304074_Chip-Seq_NSC_Mouse	0.90779045
96	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.90538191
97	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89228852
98	* HOXB7_26014856_ChIP-Seq_BT474_Human	0.89181839
99	GATA3_26560356_Chip-Seq_TH2_Human	0.86881313
100	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.86021100

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002163_abnormal_gland_morphology	2.99884987
2	MP0002837_dystrophic_cardiac_calcinosis	2.92161764
3	MP0006072_abnormal_retinal_apoptosis	2.76405220
4	MP0006292_abnormal_olfactory_placode	2.71340679
5	MP0009379_abnormal_foot_pigmentation	2.69610192
6	MP0003787_abnormal_imprinting	2.58123058
7	MP0005671_abnormal_response_to	2.36226779
8	MP0005646_abnormal_pituitary_gland	2.26506111
9	MP0005379_endocrine/exocrine_gland_phen	2.20506761
10	MP0008877_abnormal_DNA_methylation	2.19377444
11	MP0004147_increased_porphyrin_level	2.12315385
12	MP0003011_delayed_dark_adaptation	1.96514335
13	MP0003646_muscle_fatigue	1.93614453
14	MP0005645_abnormal_hypothalamus_physiol	1.86967239
15	MP0004885_abnormal_endolymph	1.83025561
16	MP0003195_calcinosis	1.81482354
17	MP0008875_abnormal_xenobiotic_pharmacok	1.79352723
18	MP0002638_abnormal_pupillary_reflex	1.75567248
19	MP0001529_abnormal_vocalization	1.72091332
20	MP0005551_abnormal_eye_electrophysiolog	1.71623493
21	MP0004145_abnormal_muscle_electrophysio	1.71586199
22	MP0000372_irregular_coat_pigmentation	1.71055475
23	MP0003123_paternal_imprinting	1.70317321
24	MP0004142_abnormal_muscle_tone	1.69167870
25	MP0001905_abnormal_dopamine_level	1.69059745
26	MP0002876_abnormal_thyroid_physiology	1.61878702
27	MP0002102_abnormal_ear_morphology	1.60515267
28	MP0001986_abnormal_taste_sensitivity	1.59603862
29	MP0001835_abnormal_antigen_presentation	1.56385753
30	MP0008872_abnormal_physiological_respon	1.53070430
31	MP0005084_abnormal_gallbladder_morpholo	1.50257347
32	MP0006276_abnormal_autonomic_nervous	1.49835704
33	MP0002653_abnormal_ependyma_morphology	1.47617265
34	MP0001968_abnormal_touch/_nociception	1.47516169
35	MP0003880_abnormal_central_pattern	1.46174511
36	MP0005253_abnormal_eye_physiology	1.41533331
37	MP0008789_abnormal_olfactory_epithelium	1.41098603
38	MP0002272_abnormal_nervous_system	1.40546396
39	MP0001984_abnormal_olfaction	1.39873597
40	MP0006036_abnormal_mitochondrial_physio	1.37873057
41	MP0009046_muscle_twitch	1.36412073
42	MP0005389_reproductive_system_phenotype	1.34958470
43	MP0003121_genomic_imprinting	1.29885098
44	MP0005075_abnormal_melanosome_morpholog	1.27986528
45	MP0002138_abnormal_hepatobiliary_system	1.27197048
46	MP0009745_abnormal_behavioral_response	1.27010053
47	MP0002160_abnormal_reproductive_system	1.25448319
48	MP0001919_abnormal_reproductive_system	1.24873290
49	MP0008775_abnormal_heart_ventricle	1.23707749
50	MP0001727_abnormal_embryo_implantation	1.23689727
51	MP0000685_abnormal_immune_system	1.20868852
52	MP0003786_premature_aging	1.19028904
53	MP0009764_decreased_sensitivity_to	1.18396837
54	MP0002736_abnormal_nociception_after	1.17672984
55	MP0005377_hearing/vestibular/ear_phenot	1.16261558
56	MP0003878_abnormal_ear_physiology	1.16261558
57	MP0002148_abnormal_hypersensitivity_rea	1.10974040
58	MP0001348_abnormal_lacrimal_gland	1.10271205
59	MP0003186_abnormal_redox_activity	1.07516069
60	MP0000631_abnormal_neuroendocrine_gland	1.07025148
61	MP0001188_hyperpigmentation	1.06921298
62	MP0005423_abnormal_somatic_nervous	1.06790437
63	MP0009785_altered_susceptibility_to	1.05385977
64	MP0004133_heterotaxia	1.04791682
65	MP0003806_abnormal_nucleotide_metabolis	1.04596300
66	MP0005332_abnormal_amino_acid	1.03834076
67	MP0002938_white_spotting	1.01132217
68	MP0002277_abnormal_respiratory_mucosa	1.00750460
69	MP0005387_immune_system_phenotype	1.00679851
70	MP0001790_abnormal_immune_system	1.00679851
71	MP0004043_abnormal_pH_regulation	0.99593764
72	MP0001800_abnormal_humoral_immune	0.98797093
73	MP0002184_abnormal_innervation	0.95179803
74	MP0005394_taste/olfaction_phenotype	0.94693471
75	MP0005499_abnormal_olfactory_system	0.94693471
76	MP0008995_early_reproductive_senescence	0.94433156
77	MP0005000_abnormal_immune_tolerance	0.92555483
78	MP0002557_abnormal_social/conspecific_i	0.92362483
79	MP0001485_abnormal_pinna_reflex	0.91749744
80	MP0002693_abnormal_pancreas_physiology	0.91691802
81	MP0005195_abnormal_posterior_eye	0.90680131
82	MP0003122_maternal_imprinting	0.90542362
83	MP0002733_abnormal_thermal_nociception	0.87635859
84	MP0001970_abnormal_pain_threshold	0.86683128
85	MP0004742_abnormal_vestibular_system	0.86600951
86	MP0002572_abnormal_emotion/affect_behav	0.83954320
87	MP0002723_abnormal_immune_serum	0.83897284
88	MP0006082_CNS_inflammation	0.83569072
89	MP0000427_abnormal_hair_cycle	0.83096396
90	MP0002752_abnormal_somatic_nervous	0.82443481
91	MP0002095_abnormal_skin_pigmentation	0.81950858
92	MP0001756_abnormal_urination	0.81279884
93	MP0001873_stomach_inflammation	0.80593003
94	MP0003724_increased_susceptibility_to	0.79428659
95	MP0000230_abnormal_systemic_arterial	0.79359573
96	MP0006035_abnormal_mitochondrial_morpho	0.78292014
97	MP0005174_abnormal_tail_pigmentation	0.77565188
98	MP0005636_abnormal_mineral_homeostasis	0.76882281
99	MP0004019_abnormal_vitamin_homeostasis	0.74730301
100	MP0002909_abnormal_adrenal_gland	0.73850035

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.07776023
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.67320326
3	Mitochondrial inheritance (HP:0001427)	4.63030752
4	Acute encephalopathy (HP:0006846)	4.47030670
5	3-Methylglutaconic aciduria (HP:0003535)	4.33493454
6	Increased CSF lactate (HP:0002490)	4.30005434
7	Progressive macrocephaly (HP:0004481)	4.27938152
8	Hepatocellular necrosis (HP:0001404)	3.76525600
9	Increased hepatocellular lipid droplets (HP:0006565)	3.64068094
10	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.60693903
11	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.60693903
12	Hepatic necrosis (HP:0002605)	3.59904730
13	Lipid accumulation in hepatocytes (HP:0006561)	3.53486331
14	Renal Fanconi syndrome (HP:0001994)	3.29423619
15	Cerebral edema (HP:0002181)	3.23386758
16	Congenital stationary night blindness (HP:0007642)	3.14092102
17	Abnormality of cells of the erythroid lineage (HP:0012130)	3.11688895
18	Abnormality of midbrain morphology (HP:0002418)	3.07378669
19	Molar tooth sign on MRI (HP:0002419)	3.07378669
20	Increased intramyocellular lipid droplets (HP:0012240)	2.98225667
21	Optic disc pallor (HP:0000543)	2.89380055
22	Increased serum lactate (HP:0002151)	2.88056396
23	Abnormal number of erythroid precursors (HP:0012131)	2.88051970
24	Pancreatic cysts (HP:0001737)	2.87767818
25	Lactic acidosis (HP:0003128)	2.85301951
26	Methylmalonic acidemia (HP:0002912)	2.85279535
27	Pancreatic fibrosis (HP:0100732)	2.84367342
28	Hyperalaninemia (HP:0003348)	2.77980440
29	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.77980440
30	Abnormality of alanine metabolism (HP:0010916)	2.77980440
31	Congenital, generalized hypertrichosis (HP:0004540)	2.75148131
32	Exertional dyspnea (HP:0002875)	2.67927275
33	Macrocytic anemia (HP:0001972)	2.64962346
34	Hyperglycinemia (HP:0002154)	2.63270290
35	Methylmalonic aciduria (HP:0012120)	2.61805077
36	Agitation (HP:0000713)	2.59892030
37	True hermaphroditism (HP:0010459)	2.57055950
38	Increased muscle lipid content (HP:0009058)	2.55715621
39	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.54250213
40	Respiratory failure (HP:0002878)	2.53526067
41	Elevated erythrocyte sedimentation rate (HP:0003565)	2.50583425
42	Reticulocytopenia (HP:0001896)	2.43047769
43	Lethargy (HP:0001254)	2.37232391
44	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.37017905
45	Nephronophthisis (HP:0000090)	2.34448791
46	Abnormality of renal resorption (HP:0011038)	2.30791415
47	Renal cortical cysts (HP:0000803)	2.30082664
48	Abnormality of the renal cortex (HP:0011035)	2.28722810
49	Abnormality of urine glucose concentration (HP:0011016)	2.26770892
50	Glycosuria (HP:0003076)	2.26770892
51	Medial flaring of the eyebrow (HP:0010747)	2.26115935
52	Abnormal rod and cone electroretinograms (HP:0008323)	2.24398061
53	Type II lissencephaly (HP:0007260)	2.24348894
54	IgG deficiency (HP:0004315)	2.21935268
55	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.21462959
56	Sclerocornea (HP:0000647)	2.18218426
57	Abolished electroretinogram (ERG) (HP:0000550)	2.16440376
58	Exercise intolerance (HP:0003546)	2.10824894
59	Leukodystrophy (HP:0002415)	2.09240178
60	Aplasia/hypoplasia of the uterus (HP:0008684)	2.01789037
61	Respiratory difficulties (HP:0002880)	1.99664047
62	Absent thumb (HP:0009777)	1.94053324
63	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.93477299
64	Pallor (HP:0000980)	1.93151427
65	CNS demyelination (HP:0007305)	1.90049434
66	Progressive microcephaly (HP:0000253)	1.87729359
67	Pendular nystagmus (HP:0012043)	1.87683526
68	Abnormality of the renal medulla (HP:0100957)	1.87671436
69	Testicular atrophy (HP:0000029)	1.86202882
70	Delayed CNS myelination (HP:0002188)	1.86133134
71	Hyperphosphaturia (HP:0003109)	1.84901763
72	Generalized aminoaciduria (HP:0002909)	1.82657913
73	Ketosis (HP:0001946)	1.82148993
74	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.81446245
75	Abnormal drinking behavior (HP:0030082)	1.80850673
76	Polydipsia (HP:0001959)	1.80850673
77	Abnormality of vitamin B metabolism (HP:0004340)	1.80622317
78	Dicarboxylic aciduria (HP:0003215)	1.79170588
79	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.79170588
80	Abnormality of magnesium homeostasis (HP:0004921)	1.77597500
81	X-linked dominant inheritance (HP:0001423)	1.76813938
82	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.76359379
83	Absent/shortened dynein arms (HP:0200106)	1.75188817
84	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.75188817
85	Asplenia (HP:0001746)	1.73343518
86	Hypomagnesemia (HP:0002917)	1.72116253
87	Gait imbalance (HP:0002141)	1.71822701
88	Hypoplasia of the uterus (HP:0000013)	1.70910611
89	Abnormality of serum amino acid levels (HP:0003112)	1.70799608
90	Type 2 muscle fiber atrophy (HP:0003554)	1.69410997
91	Microretrognathia (HP:0000308)	1.68188879
92	Adrenal hypoplasia (HP:0000835)	1.67491070
93	Attenuation of retinal blood vessels (HP:0007843)	1.67312905
94	Congenital primary aphakia (HP:0007707)	1.66928755
95	Emotional lability (HP:0000712)	1.66801699
96	Cleft eyelid (HP:0000625)	1.66590146
97	Cystic liver disease (HP:0006706)	1.64180301
98	Myokymia (HP:0002411)	1.62795237
99	Blindness (HP:0000618)	1.60427995
100	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.60100863

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	3.94554845
2	ZAK	3.29150417
3	BCKDK	3.03065621
4	TXK	2.85870913
5	GRK1	2.68928274
6	ADRBK2	2.56209166
7	FRK	2.48979964
8	TAOK3	2.39587717
9	MAP4K2	2.35531048
10	WNK4	2.22555043
11	STK16	2.14211822
12	BMPR1B	2.12670039
13	NME2	2.08412869
14	WNK3	1.88181229
15	VRK1	1.61216001
16	NUAK1	1.59267332
17	PDK2	1.55847946
18	LIMK1	1.50450855
19	DYRK2	1.45608010
20	VRK2	1.44732651
21	MAP3K4	1.39004890
22	PHKG2	1.27120924
23	PHKG1	1.27120924
24	CSNK1G3	1.25201811
25	PINK1	1.23597183
26	CSNK1G2	1.21358612
27	CAMKK2	1.17629096
28	MAP3K12	1.13524713
29	INSRR	1.12734810
30	OXSR1	1.11591859
31	TIE1	1.11447256
32	RPS6KA5	1.05197371
33	ITK	0.99589095
34	CSNK1G1	0.98502881
35	TESK2	0.98270195
36	CASK	0.97880069
37	IKBKB	0.92314915
38	GRK7	0.92236866
39	ABL2	0.92139301
40	MAP2K6	0.91664581
41	MAP2K7	0.91199887
42	CSNK1A1L	0.90614991
43	MAPK13	0.90220841
44	KDR	0.90197987
45	FES	0.90073281
46	SYK	0.89539900
47	ADRBK1	0.87404180
48	STK39	0.86947931
49	ACVR1B	0.84153420
50	KIT	0.82850512
51	EIF2AK1	0.76389186
52	GRK6	0.76004179
53	CDK19	0.75750249
54	CDK8	0.75039414
55	PRKCI	0.74652882
56	AURKA	0.73753602
57	MAP2K2	0.72415148
58	PRKCQ	0.67184116
59	MAP3K11	0.66112808
60	TNIK	0.66062452
61	TEC	0.65943022
62	PLK4	0.65075981
63	MST4	0.65072644
64	PRKCG	0.64986589
65	NEK1	0.64381599
66	NME1	0.63306380
67	PAK3	0.60982411
68	IKBKE	0.60172342
69	GRK5	0.56020824
70	LCK	0.55386845
71	MAPKAPK3	0.55183797
72	MUSK	0.54010966
73	PRKACA	0.52526116
74	MAP3K9	0.52433014
75	CSNK2A2	0.51424629
76	LYN	0.50838106
77	CSNK1A1	0.50069306
78	MINK1	0.48918611
79	CSNK2A1	0.48770325
80	BTK	0.48029142
81	PLK2	0.46788955
82	MAPKAPK5	0.46223485
83	DAPK3	0.45553084
84	PRKCA	0.45231800
85	DAPK2	0.44825699
86	PRKCE	0.44343499
87	MAP4K1	0.43441304
88	PLK3	0.42301849
89	MYLK	0.41980482
90	PTK2B	0.40693739
91	PIM1	0.40659088
92	PRKCD	0.39503457
93	BUB1	0.38678873
94	TBK1	0.38458430
95	CHEK2	0.38368564
96	OBSCN	0.37903045
97	PIM2	0.37668220
98	PIK3CA	0.37280030
99	DYRK3	0.36593438
100	PLK1	0.35233938

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.66445226
2	Ribosome_Homo sapiens_hsa03010	4.22711413
3	Parkinsons disease_Homo sapiens_hsa05012	3.82820678
4	Alzheimers disease_Homo sapiens_hsa05010	2.65465082
5	Proteasome_Homo sapiens_hsa03050	2.48497252
6	Protein export_Homo sapiens_hsa03060	2.47314296
7	Huntingtons disease_Homo sapiens_hsa05016	2.44802647
8	Asthma_Homo sapiens_hsa05310	2.39355344
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.34386971
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.15811489
11	RNA polymerase_Homo sapiens_hsa03020	2.15764806
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.06154671
13	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.05728842
14	Allograft rejection_Homo sapiens_hsa05330	1.96248853
15	Graft-versus-host disease_Homo sapiens_hsa05332	1.95438617
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.89659885
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.85266153
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.82768700
19	Type I diabetes mellitus_Homo sapiens_hsa04940	1.80797084
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.74006411
21	Sulfur metabolism_Homo sapiens_hsa00920	1.64358972
22	Phototransduction_Homo sapiens_hsa04744	1.55287165
23	Sulfur relay system_Homo sapiens_hsa04122	1.48465294
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.43389389
25	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.38212627
26	Homologous recombination_Homo sapiens_hsa03440	1.34550006
27	RNA degradation_Homo sapiens_hsa03018	1.34547046
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.29634784
29	Rheumatoid arthritis_Homo sapiens_hsa05323	1.15361671
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.14998504
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.13863467
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.12357039
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.12044548
34	Collecting duct acid secretion_Homo sapiens_hsa04966	1.07497087
35	Basal transcription factors_Homo sapiens_hsa03022	1.06159566
36	Primary immunodeficiency_Homo sapiens_hsa05340	1.05779235
37	Antigen processing and presentation_Homo sapiens_hsa04612	1.04827338
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.04404094
39	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.03140301
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.01572702
41	Propanoate metabolism_Homo sapiens_hsa00640	0.98383273
42	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.94380086
43	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.93549723
44	Caffeine metabolism_Homo sapiens_hsa00232	0.91309367
45	Fanconi anemia pathway_Homo sapiens_hsa03460	0.90821845
46	Peroxisome_Homo sapiens_hsa04146	0.90593333
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90039147
48	Selenocompound metabolism_Homo sapiens_hsa00450	0.87903441
49	Regulation of autophagy_Homo sapiens_hsa04140	0.82978027
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.82964341
51	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.82132362
52	Purine metabolism_Homo sapiens_hsa00230	0.80772638
53	Butanoate metabolism_Homo sapiens_hsa00650	0.79820498
54	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.79282250
55	One carbon pool by folate_Homo sapiens_hsa00670	0.77887910
56	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.73962386
57	Metabolic pathways_Homo sapiens_hsa01100	0.72008661
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.69093504
59	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.68319039
60	Nicotine addiction_Homo sapiens_hsa05033	0.66436160
61	Mismatch repair_Homo sapiens_hsa03430	0.65377428
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65241539
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.62535659
64	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.62235683
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.60789922
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.57939463
67	Folate biosynthesis_Homo sapiens_hsa00790	0.55886440
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.55173535
69	Alcoholism_Homo sapiens_hsa05034	0.54544796
70	Viral myocarditis_Homo sapiens_hsa05416	0.53460046
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.53168414
72	Fatty acid elongation_Homo sapiens_hsa00062	0.52982313
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.51615823
74	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50360377
75	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.50132708
76	DNA replication_Homo sapiens_hsa03030	0.49430362
77	Retinol metabolism_Homo sapiens_hsa00830	0.48464891
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48070460
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.47046188
80	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.46767902
81	Spliceosome_Homo sapiens_hsa03040	0.46696628
82	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.46088565
83	Morphine addiction_Homo sapiens_hsa05032	0.43842168
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.43489384
85	RNA transport_Homo sapiens_hsa03013	0.43114187
86	Olfactory transduction_Homo sapiens_hsa04740	0.41787596
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.41576912
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41258305
89	Base excision repair_Homo sapiens_hsa03410	0.39251859
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38475495
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.37629449
92	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.36261082
93	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.35581895
94	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.32475187
95	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.31868420
96	Tyrosine metabolism_Homo sapiens_hsa00350	0.31773084
97	Pyruvate metabolism_Homo sapiens_hsa00620	0.31309155
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.31079422
99	Phenylalanine metabolism_Homo sapiens_hsa00360	0.30834253
100	Steroid biosynthesis_Homo sapiens_hsa00100	0.29395442

ATP5EP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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