ATP5F1P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)6.75855633
2regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)6.14198576
3cilium movement (GO:0003341)6.07582499
4vitamin transmembrane transport (GO:0035461)6.00043914
5regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033395.99178819
6negative regulation of metanephros development (GO:0072217)5.88114055
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.78335585
8motile cilium assembly (GO:0044458)5.59657801
9positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)5.56676953
10regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)5.56676953
11regulation of nephron tubule epithelial cell differentiation (GO:0072182)5.54370364
12regulation of podosome assembly (GO:0071801)5.42103197
13cilium or flagellum-dependent cell motility (GO:0001539)5.40345862
14epithelial cilium movement (GO:0003351)5.05553019
15regulation of epithelial cell differentiation involved in kidney development (GO:2000696)4.94667131
16head development (GO:0060322)4.93934775
17photoreceptor cell differentiation (GO:0046530)4.41028945
18eye photoreceptor cell differentiation (GO:0001754)4.41028945
19ventricular system development (GO:0021591)4.40415628
20regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.33868159
21negative regulation of kidney development (GO:0090185)4.20514658
22positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.16394899
23regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.05985659
24regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.02022377
25response to nitrosative stress (GO:0051409)4.01945091
26lung epithelium development (GO:0060428)4.00455086
27positive regulation of osteoclast differentiation (GO:0045672)3.93785823
28C4-dicarboxylate transport (GO:0015740)3.90791561
29axoneme assembly (GO:0035082)3.90462063
30intraciliary transport (GO:0042073)3.87906431
31negative regulation of interleukin-17 production (GO:0032700)3.87865065
32L-serine transport (GO:0015825)3.77800590
33neurotransmitter catabolic process (GO:0042135)3.74062388
34auditory behavior (GO:0031223)3.71314248
35seminiferous tubule development (GO:0072520)3.62669682
36regulation of interleukin-12 biosynthetic process (GO:0045075)3.60950483
37lactate metabolic process (GO:0006089)3.57439666
38retinal rod cell development (GO:0046548)3.57019835
39lung vasculature development (GO:0060426)3.51912895
40regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.49067075
41cilium organization (GO:0044782)3.47173282
42lateral sprouting from an epithelium (GO:0060601)3.46305594
43regulation of somitogenesis (GO:0014807)3.43199982
44cilium assembly (GO:0042384)3.36640205
45regulation of cilium movement (GO:0003352)3.28320602
46left/right pattern formation (GO:0060972)3.26929515
47limb development (GO:0060173)3.25783167
48appendage development (GO:0048736)3.25783167
49extracellular fibril organization (GO:0043206)3.23813155
50regulation of non-canonical Wnt signaling pathway (GO:2000050)3.22081314
51regulation of metanephros development (GO:0072215)3.17667137
52ear development (GO:0043583)3.13365609
53cilium morphogenesis (GO:0060271)3.13223665
54embryonic digestive tract development (GO:0048566)3.10034688
55positive regulation of alcohol biosynthetic process (GO:1902932)3.08122249
56smooth muscle tissue development (GO:0048745)3.07107020
57adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.02727459
58negative regulation of neurological system process (GO:0031645)3.01053672
59negative regulation of chondrocyte differentiation (GO:0032331)3.00936657
60forebrain neuron differentiation (GO:0021879)2.99748484
61asymmetric protein localization (GO:0008105)2.96199636
62organelle disassembly (GO:1903008)2.96052897
63establishment of nucleus localization (GO:0040023)2.95381897
64negative regulation of smooth muscle cell migration (GO:0014912)2.89468908
65fibril organization (GO:0097435)2.89000069
66negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83620343
67layer formation in cerebral cortex (GO:0021819)2.81297655
68fibroblast migration (GO:0010761)2.79140265
69mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.75602784
70glial cell migration (GO:0008347)2.75530727
71retinal cone cell development (GO:0046549)2.71580492
72regulation of isotype switching to IgG isotypes (GO:0048302)2.71132152
73protein maturation by protein folding (GO:0022417)2.68872112
74serine transport (GO:0032329)2.65874480
75keratan sulfate catabolic process (GO:0042340)2.65493412
76pyrimidine-containing compound transmembrane transport (GO:0072531)2.65270228
77positive regulation of steroid biosynthetic process (GO:0010893)2.62654671
78regulation of vitamin D biosynthetic process (GO:0060556)2.59103368
79skeletal muscle organ development (GO:0060538)2.56784453
80cellular component assembly involved in morphogenesis (GO:0010927)2.56505139
81mesenchymal cell differentiation involved in kidney development (GO:0072161)2.52510352
82mesenchymal cell differentiation involved in renal system development (GO:2001012)2.52510352
83metanephric mesenchyme development (GO:0072075)2.51763771
84retina layer formation (GO:0010842)2.50725639
85microtubule bundle formation (GO:0001578)2.49364318
86negative regulation of cartilage development (GO:0061037)2.44878571
87embryonic skeletal joint morphogenesis (GO:0060272)2.43717038
88ribonucleoprotein complex disassembly (GO:0032988)2.41829705
89forelimb morphogenesis (GO:0035136)2.40737533
90negative regulation of leukocyte chemotaxis (GO:0002689)2.37958611
91ventricular septum development (GO:0003281)2.37936979
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.37400357
93auditory receptor cell stereocilium organization (GO:0060088)2.36189034
94inner ear receptor stereocilium organization (GO:0060122)2.35141569
95regulation of chondrocyte differentiation (GO:0032330)2.34979670
96L-alpha-amino acid transmembrane transport (GO:1902475)2.34884940
97protein heterotrimerization (GO:0070208)2.34354612
98negative regulation of synaptic transmission, GABAergic (GO:0032229)2.33488921
99positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.33105020
100regulation of respiratory system process (GO:0044065)2.32968174

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.15381415
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.08432582
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.03786887
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.98159458
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.97038118
6EZH2_22144423_ChIP-Seq_EOC_Human2.82671250
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.47970572
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.38135046
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.34340141
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15160017
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.14696678
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01817187
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95927077
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95770813
15TP53_16413492_ChIP-PET_HCT116_Human1.87345737
16PIAS1_25552417_ChIP-Seq_VCAP_Human1.84732998
17PCGF2_27294783_Chip-Seq_NPCs_Mouse1.83660454
18PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79923367
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.77613931
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75059817
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64372952
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62494326
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62426793
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61125814
25SMAD4_21799915_ChIP-Seq_A2780_Human1.60570811
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56929385
27DROSHA_22980978_ChIP-Seq_HELA_Human1.55450517
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.52146189
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51275660
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50467749
31NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.47976861
32NRF2_20460467_ChIP-Seq_MEFs_Mouse1.47976861
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47353630
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.46883516
35TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46458399
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39112307
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.39077225
38ARNT_22903824_ChIP-Seq_MCF-7_Human1.37491065
39AHR_22903824_ChIP-Seq_MCF-7_Human1.37170117
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35208036
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35208036
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30114215
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.27706543
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26326037
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25820740
46TAF15_26573619_Chip-Seq_HEK293_Human1.24463471
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24344992
48VDR_22108803_ChIP-Seq_LS180_Human1.24303374
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23969631
50BCAT_22108803_ChIP-Seq_LS180_Human1.22922123
51CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22012724
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21252753
53SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20750808
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.18908207
55WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18838673
56JUN_21703547_ChIP-Seq_K562_Human1.17329501
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16746012
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16283011
59STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15453256
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15433241
61TAL1_26923725_Chip-Seq_HPCs_Mouse1.14152392
62LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13801400
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.12827493
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12224601
65P300_19829295_ChIP-Seq_ESCs_Human1.11556374
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10418040
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10113526
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.09985388
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09538070
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09233521
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08487960
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07261978
73TCF4_22108803_ChIP-Seq_LS180_Human1.05313116
74ZNF274_21170338_ChIP-Seq_K562_Hela1.04910053
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04814651
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04723500
77CBP_20019798_ChIP-Seq_JUKART_Human1.04688236
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04688236
79JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03220378
80CBP_21632823_ChIP-Seq_H3396_Human1.01174586
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00591891
82SMAD4_21741376_ChIP-Seq_EPCs_Human0.99786231
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99429466
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98946578
85TCF4_23295773_ChIP-Seq_U87_Human0.98684807
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97566979
87SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95843867
88TP63_23658742_ChIP-Seq_EP156T_Human0.94386748
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94005184
90EWS_26573619_Chip-Seq_HEK293_Human0.91065000
91RUNX2_22187159_ChIP-Seq_PCA_Human0.90254512
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89703915
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89634218
94STAT3_23295773_ChIP-Seq_U87_Human0.89365269
95ELK4_26923725_Chip-Seq_MESODERM_Mouse0.89270168
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89027856
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88887376
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88838035
99TP53_18474530_ChIP-ChIP_U2OS_Human0.88434335
100SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87887360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001958_emphysema4.59995907
2MP0002102_abnormal_ear_morphology3.76670237
3MP0009780_abnormal_chondrocyte_physiolo3.54061192
4MP0005503_abnormal_tendon_morphology3.53619980
5MP0001984_abnormal_olfaction3.24130237
6MP0003878_abnormal_ear_physiology2.71502965
7MP0005377_hearing/vestibular/ear_phenot2.71502965
8MP0001873_stomach_inflammation2.63943827
9MP0001348_abnormal_lacrimal_gland2.53299973
10MP0008789_abnormal_olfactory_epithelium2.47601521
11MP0002909_abnormal_adrenal_gland2.36999395
12MP0003136_yellow_coat_color2.36239512
13MP0006054_spinal_hemorrhage2.33932327
14MP0004782_abnormal_surfactant_physiolog2.31629870
15MP0004134_abnormal_chest_morphology2.19186851
16MP0003787_abnormal_imprinting2.15357587
17MP0002837_dystrophic_cardiac_calcinosis2.14161970
18MP0000534_abnormal_ureter_morphology1.94535633
19MP0008438_abnormal_cutaneous_collagen1.90693636
20MP0005623_abnormal_meninges_morphology1.87820715
21MP0003279_aneurysm1.86039699
22MP0004859_abnormal_synaptic_plasticity1.80052023
23MP0006072_abnormal_retinal_apoptosis1.70795366
24MP0005394_taste/olfaction_phenotype1.68954154
25MP0005499_abnormal_olfactory_system1.68954154
26MP0008875_abnormal_xenobiotic_pharmacok1.67118299
27MP0003705_abnormal_hypodermis_morpholog1.55515283
28MP0010368_abnormal_lymphatic_system1.51970718
29MP0005253_abnormal_eye_physiology1.49416930
30MP0000537_abnormal_urethra_morphology1.44678943
31MP0003122_maternal_imprinting1.41798348
32MP0003950_abnormal_plasma_membrane1.40581728
33MP0001177_atelectasis1.40339849
34MP0001835_abnormal_antigen_presentation1.39963680
35MP0003186_abnormal_redox_activity1.39782480
36MP0002933_joint_inflammation1.36948297
37MP0005389_reproductive_system_phenotype1.34696074
38MP0004885_abnormal_endolymph1.34253805
39MP0005508_abnormal_skeleton_morphology1.33936825
40MP0003172_abnormal_lysosome_physiology1.27421848
41MP0002133_abnormal_respiratory_system1.25635417
42MP0005388_respiratory_system_phenotype1.25635417
43MP0005248_abnormal_Harderian_gland1.24870228
44MP0001299_abnormal_eye_distance/1.23951951
45MP0004133_heterotaxia1.22515059
46MP0002160_abnormal_reproductive_system1.20931335
47MP0003283_abnormal_digestive_organ1.20375370
48MP0010386_abnormal_urinary_bladder1.18346593
49MP0008569_lethality_at_weaning1.18091614
50MP0008877_abnormal_DNA_methylation1.17824658
51MP0002653_abnormal_ependyma_morphology1.16878719
52MP0002557_abnormal_social/conspecific_i1.14863958
53MP0003942_abnormal_urinary_system1.10159266
54MP0002089_abnormal_postnatal_growth/wei1.07962550
55MP0002116_abnormal_craniofacial_bone1.07636911
56MP0000778_abnormal_nervous_system1.05613304
57MP0005187_abnormal_penis_morphology1.04482744
58MP0005275_abnormal_skin_tensile1.01919933
59MP0000383_abnormal_hair_follicle1.01566431
60MP0004272_abnormal_basement_membrane0.98986652
61MP0003385_abnormal_body_wall0.98524631
62MP0008872_abnormal_physiological_respon0.95306728
63MP0005257_abnormal_intraocular_pressure0.94509636
64MP0005670_abnormal_white_adipose0.94332574
65MP0008961_abnormal_basal_metabolism0.91547419
66MP0009046_muscle_twitch0.91412223
67MP0001970_abnormal_pain_threshold0.90541153
68MP0002751_abnormal_autonomic_nervous0.90538568
69MP0005171_absent_coat_pigmentation0.87198989
70MP0001919_abnormal_reproductive_system0.85832764
71MP0005167_abnormal_blood-brain_barrier0.85092414
72MP0002115_abnormal_skeleton_extremities0.84550287
73MP0005551_abnormal_eye_electrophysiolog0.84169299
74MP0002734_abnormal_mechanical_nocicepti0.81680950
75MP0009053_abnormal_anal_canal0.81182701
76MP0010678_abnormal_skin_adnexa0.79691177
77MP0002282_abnormal_trachea_morphology0.79418534
78MP0003121_genomic_imprinting0.79284311
79MP0001881_abnormal_mammary_gland0.79270257
80MP0010352_gastrointestinal_tract_polyps0.79234775
81MP0002108_abnormal_muscle_morphology0.79130844
82MP0005083_abnormal_biliary_tract0.78589056
83MP0005448_abnormal_energy_balance0.78140121
84MP0005195_abnormal_posterior_eye0.77742483
85MP0001485_abnormal_pinna_reflex0.76053421
86MP0000026_abnormal_inner_ear0.73909022
87MP0001664_abnormal_digestion0.73752368
88MP0002896_abnormal_bone_mineralization0.69728430
89MP0001963_abnormal_hearing_physiology0.69487540
90MP0002233_abnormal_nose_morphology0.69342635
91MP0002932_abnormal_joint_morphology0.69228369
92MP0004185_abnormal_adipocyte_glucose0.69128772
93MP0005390_skeleton_phenotype0.68686605
94MP0002090_abnormal_vision0.68630781
95MP0002114_abnormal_axial_skeleton0.67489591
96MP0001849_ear_inflammation0.66150124
97MP0002572_abnormal_emotion/affect_behav0.66085389
98MP0000427_abnormal_hair_cycle0.64351407
99MP0002752_abnormal_somatic_nervous0.64094682
100MP0000013_abnormal_adipose_tissue0.63697714

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.95212209
2Abnormal ciliary motility (HP:0012262)5.92828310
3Abnormal respiratory epithelium morphology (HP:0012253)5.90429180
4Abnormal respiratory motile cilium morphology (HP:0005938)5.90429180
5Abnormal respiratory motile cilium physiology (HP:0012261)5.76465764
6Rhinitis (HP:0012384)5.53979929
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.97797149
8Absent/shortened dynein arms (HP:0200106)4.97797149
9Enlarged penis (HP:0000040)4.15789108
10Chronic bronchitis (HP:0004469)3.87806966
11Abnormality of midbrain morphology (HP:0002418)3.77292349
12Molar tooth sign on MRI (HP:0002419)3.77292349
13Pancreatic fibrosis (HP:0100732)3.69118114
14Occipital encephalocele (HP:0002085)3.67799802
15True hermaphroditism (HP:0010459)3.62407002
16Pancreatic cysts (HP:0001737)3.52281222
17Aplasia/Hypoplasia of the spleen (HP:0010451)3.49125956
18Bronchiectasis (HP:0002110)3.43178747
19Arterial tortuosity (HP:0005116)3.36570115
20Vascular tortuosity (HP:0004948)3.28143711
21Supernumerary spleens (HP:0009799)3.25626538
22Congenital, generalized hypertrichosis (HP:0004540)3.11016364
23Nasal polyposis (HP:0100582)3.00154803
24Nephronophthisis (HP:0000090)2.96592922
25Cystic liver disease (HP:0006706)2.86103351
26Absent frontal sinuses (HP:0002688)2.80650974
27Abnormality of the nasal mucosa (HP:0000433)2.71279027
28Aortic dissection (HP:0002647)2.69493330
29Coronal craniosynostosis (HP:0004440)2.68182093
30Recurrent sinusitis (HP:0011108)2.67460136
31Tubular atrophy (HP:0000092)2.62811763
32Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.62051740
33Protrusio acetabuli (HP:0003179)2.61046693
34Postaxial foot polydactyly (HP:0001830)2.58666622
35Macroorchidism (HP:0000053)2.54709514
36Partial duplication of thumb phalanx (HP:0009944)2.51138613
37Gait imbalance (HP:0002141)2.49075202
38Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.42835978
39Postaxial hand polydactyly (HP:0001162)2.42560046
40Facial shape deformation (HP:0011334)2.35106958
41Potter facies (HP:0002009)2.35106958
42Abnormality of dentin (HP:0010299)2.33427046
43Congenital primary aphakia (HP:0007707)2.27427940
44Medial flaring of the eyebrow (HP:0010747)2.27191782
45Bronchitis (HP:0012387)2.25367785
46Hepatoblastoma (HP:0002884)2.24591662
47Broad metatarsal (HP:0001783)2.24207712
48Abnormality of the renal medulla (HP:0100957)2.17405686
49Ankle contracture (HP:0006466)2.16317798
50Abnormal pancreas size (HP:0012094)2.15323393
51Bicornuate uterus (HP:0000813)2.11996252
52Abolished electroretinogram (ERG) (HP:0000550)2.11971199
53Partial duplication of the phalanx of hand (HP:0009999)2.05516262
54Chronic sinusitis (HP:0011109)2.04336928
55Asplenia (HP:0001746)2.03166137
56Infantile muscular hypotonia (HP:0008947)2.02677181
57Congenital hepatic fibrosis (HP:0002612)1.98453962
58Chronic hepatic failure (HP:0100626)1.96842268
59Premature rupture of membranes (HP:0001788)1.96593462
60Abnormal biliary tract physiology (HP:0012439)1.94168355
61Bile duct proliferation (HP:0001408)1.94168355
62Nephrogenic diabetes insipidus (HP:0009806)1.92875760
63Anencephaly (HP:0002323)1.90973415
64Preaxial hand polydactyly (HP:0001177)1.87232662
65Pulmonary artery stenosis (HP:0004415)1.87052937
66Abnormality of the frontal sinuses (HP:0002687)1.86968906
67Aplasia/Hypoplasia of the tongue (HP:0010295)1.86128543
68Spinal muscular atrophy (HP:0007269)1.86077440
69Shallow orbits (HP:0000586)1.85486509
70Asymmetry of the thorax (HP:0001555)1.83184560
71Intellectual disability, moderate (HP:0002342)1.82533509
72Soft skin (HP:0000977)1.79339605
73Renal hypoplasia (HP:0000089)1.77284970
74Broad foot (HP:0001769)1.77183102
75Aortic aneurysm (HP:0004942)1.77123370
76Vaginal atresia (HP:0000148)1.76730726
77Aortic valve stenosis (HP:0001650)1.76437270
78Torticollis (HP:0000473)1.75523204
79Aortic regurgitation (HP:0001659)1.72762203
80Abnormal drinking behavior (HP:0030082)1.72039022
81Polydipsia (HP:0001959)1.72039022
82Neonatal short-limb short stature (HP:0008921)1.69688379
83Large for gestational age (HP:0001520)1.66433332
84Increased corneal curvature (HP:0100692)1.65782289
85Keratoconus (HP:0000563)1.65782289
86Glucose intolerance (HP:0000833)1.65754100
87Abnormality of the aortic arch (HP:0012303)1.65081912
88Atelectasis (HP:0100750)1.63583461
89Annular pancreas (HP:0001734)1.63131146
90Sclerocornea (HP:0000647)1.62890079
91Gout (HP:0001997)1.62070564
92Aplasia/Hypoplasia of the lens (HP:0008063)1.61981353
93Hypopigmentation of the fundus (HP:0007894)1.61795180
94Abnormality of macular pigmentation (HP:0008002)1.60414177
95Furrowed tongue (HP:0000221)1.59589371
96Recurrent otitis media (HP:0000403)1.59317559
97Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.58867857
98Vertebral hypoplasia (HP:0008417)1.58867857
99Genital tract atresia (HP:0001827)1.55378318
100Stage 5 chronic kidney disease (HP:0003774)1.54049408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.53938701
2MAPK152.88292249
3FRK2.85105628
4GRK12.85089577
5NEK92.63869251
6RIPK12.62156568
7MST42.57473240
8BCR2.51338097
9ERBB32.44122050
10EPHB22.22992093
11MAP4K22.19259665
12ADRBK22.12408549
13NTRK32.04710869
14CSNK1G22.04647342
15TXK2.02314262
16CSNK1G31.99825893
17FER1.97689855
18CSNK1G11.93274311
19CSNK1A1L1.87058059
20BMPR21.75123408
21EPHA21.70234632
22PINK11.63345766
23CASK1.60979487
24TNIK1.60373332
25EPHA41.46289338
26TAOK31.29552315
27KIT1.26428875
28RPS6KA21.16292314
29NME11.08324747
30TYK21.06892355
31TTN1.06692679
32EPHA31.05251711
33STK391.04141591
34MKNK21.03213509
35CAMKK10.99954296
36MAP3K90.99947609
37PAK30.99244953
38PRKD30.98198852
39PAK40.96947532
40FGFR20.95615178
41PLK20.92430099
42ROCK20.87863878
43DDR20.86880640
44FES0.84433123
45NTRK10.83929462
46OXSR10.82277919
47STK380.81250301
48PRKCE0.78770244
49PDGFRB0.78273844
50TEC0.78009678
51TGFBR20.76897634
52TYRO30.74189121
53RPS6KA40.74188490
54ERBB20.74094191
55EIF2AK30.73708064
56MKNK10.72582740
57PTK20.71374752
58VRK20.70600175
59CDK60.69437053
60CAMKK20.67639556
61MARK10.66519292
62FGFR10.66339178
63DYRK1A0.65244873
64EIF2AK20.63784617
65MYLK0.61769658
66MAP3K70.61488630
67PTK2B0.61083671
68PRKCH0.57739348
69PRKD10.57024395
70WNK30.56737505
71CSK0.56147694
72LRRK20.55296410
73GSK3A0.54866531
74CAMK2D0.54336790
75ALK0.53229196
76CSNK1A10.51229760
77DYRK1B0.50450655
78NLK0.50432052
79MAP3K120.49819774
80ABL20.48845004
81JAK10.47272428
82RPS6KC10.46540067
83RPS6KL10.46540067
84MINK10.45202036
85CDK90.44953370
86ADRBK10.44419244
87MAPK130.43360669
88CSNK1E0.42501796
89PDGFRA0.41579710
90RPS6KA60.38778527
91LATS10.38755180
92STK30.37637866
93MAP2K70.36969843
94CSNK1D0.36047608
95EIF2AK10.34960797
96SGK20.34947770
97CLK10.34794689
98PTK60.34669056
99AKT30.32486485
100CAMK2A0.31393442

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.80429421
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.29136591
3Proteasome_Homo sapiens_hsa030503.11256044
4Propanoate metabolism_Homo sapiens_hsa006402.98864434
5Vitamin B6 metabolism_Homo sapiens_hsa007502.74826462
6Phototransduction_Homo sapiens_hsa047442.30708668
7Protein export_Homo sapiens_hsa030602.29625198
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.19719085
9Sphingolipid metabolism_Homo sapiens_hsa006002.10025560
10Phenylalanine metabolism_Homo sapiens_hsa003601.79099472
11Butanoate metabolism_Homo sapiens_hsa006501.73246393
12RNA polymerase_Homo sapiens_hsa030201.68293331
13beta-Alanine metabolism_Homo sapiens_hsa004101.63062232
14Regulation of autophagy_Homo sapiens_hsa041401.60320570
15Nitrogen metabolism_Homo sapiens_hsa009101.60142503
16Basal cell carcinoma_Homo sapiens_hsa052171.53671995
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49923355
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.49436138
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48177469
20Hippo signaling pathway_Homo sapiens_hsa043901.43992637
21Salivary secretion_Homo sapiens_hsa049701.38595176
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37413905
23Chemical carcinogenesis_Homo sapiens_hsa052041.36229799
24Non-homologous end-joining_Homo sapiens_hsa034501.36148809
25ECM-receptor interaction_Homo sapiens_hsa045121.34515655
26Rheumatoid arthritis_Homo sapiens_hsa053231.32416422
27Ovarian steroidogenesis_Homo sapiens_hsa049131.31846726
28Thyroid hormone synthesis_Homo sapiens_hsa049181.31204501
29Fatty acid metabolism_Homo sapiens_hsa012121.31120775
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30671948
31Amoebiasis_Homo sapiens_hsa051461.26429417
32Protein digestion and absorption_Homo sapiens_hsa049741.19018229
33Lysosome_Homo sapiens_hsa041421.18626281
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.16171761
35Tyrosine metabolism_Homo sapiens_hsa003501.15326913
36Huntingtons disease_Homo sapiens_hsa050161.10887907
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03887140
38Histidine metabolism_Homo sapiens_hsa003401.03853702
39Hedgehog signaling pathway_Homo sapiens_hsa043401.02803472
40Wnt signaling pathway_Homo sapiens_hsa043101.02478961
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02089683
42PPAR signaling pathway_Homo sapiens_hsa033200.99115781
43Peroxisome_Homo sapiens_hsa041460.98994787
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97302913
45Homologous recombination_Homo sapiens_hsa034400.94954772
46Insulin secretion_Homo sapiens_hsa049110.93924558
47Glutamatergic synapse_Homo sapiens_hsa047240.93340113
48Glycosaminoglycan degradation_Homo sapiens_hsa005310.93039268
49Melanogenesis_Homo sapiens_hsa049160.91549359
50Glutathione metabolism_Homo sapiens_hsa004800.91423771
51TGF-beta signaling pathway_Homo sapiens_hsa043500.91376227
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86313896
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86124150
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85966662
55N-Glycan biosynthesis_Homo sapiens_hsa005100.82543171
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81692007
57Steroid biosynthesis_Homo sapiens_hsa001000.80983932
58Gastric acid secretion_Homo sapiens_hsa049710.78724207
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77011232
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76978286
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76951359
62Nucleotide excision repair_Homo sapiens_hsa034200.75131905
63Cocaine addiction_Homo sapiens_hsa050300.74945531
64Vibrio cholerae infection_Homo sapiens_hsa051100.70818713
65Adherens junction_Homo sapiens_hsa045200.70739116
66Dilated cardiomyopathy_Homo sapiens_hsa054140.69671265
67Axon guidance_Homo sapiens_hsa043600.67651941
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65539199
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64144186
70ABC transporters_Homo sapiens_hsa020100.64071890
71Pancreatic secretion_Homo sapiens_hsa049720.62143637
72Malaria_Homo sapiens_hsa051440.60745170
73Circadian entrainment_Homo sapiens_hsa047130.60061640
74Pyrimidine metabolism_Homo sapiens_hsa002400.59924116
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58651224
76Pyruvate metabolism_Homo sapiens_hsa006200.56165438
77Fatty acid biosynthesis_Homo sapiens_hsa000610.56141985
78Oxidative phosphorylation_Homo sapiens_hsa001900.55824108
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.55129587
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53304708
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51668938
82Linoleic acid metabolism_Homo sapiens_hsa005910.51152904
83Other glycan degradation_Homo sapiens_hsa005110.49724459
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49378873
85Fatty acid degradation_Homo sapiens_hsa000710.48715786
86Collecting duct acid secretion_Homo sapiens_hsa049660.47891532
87Focal adhesion_Homo sapiens_hsa045100.46591938
88Serotonergic synapse_Homo sapiens_hsa047260.46533164
89Synaptic vesicle cycle_Homo sapiens_hsa047210.46484699
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45970118
91Ras signaling pathway_Homo sapiens_hsa040140.45465743
92GABAergic synapse_Homo sapiens_hsa047270.44727639
93Calcium signaling pathway_Homo sapiens_hsa040200.43862515
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42283500
95cAMP signaling pathway_Homo sapiens_hsa040240.40434877
96Rap1 signaling pathway_Homo sapiens_hsa040150.39346562
97Arachidonic acid metabolism_Homo sapiens_hsa005900.38817718
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38505364
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.38055147
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37642541

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