ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ATP synthesis coupled proton transport (GO:0015986)	5.54356458
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.54356458
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.36257492
4	urate metabolic process (GO:0046415)	4.35847116
5	DNA deamination (GO:0045006)	4.25287526
6	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	4.24119230
7	purine-containing compound salvage (GO:0043101)	4.13311089
8	NAD biosynthetic process (GO:0009435)	4.05553775
9	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.01355966
10	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.95477770
11	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.93672252
12	water-soluble vitamin biosynthetic process (GO:0042364)	3.85917059
13	glyoxylate metabolic process (GO:0046487)	3.78585518
14	platelet dense granule organization (GO:0060155)	3.72011559
15	respiratory electron transport chain (GO:0022904)	3.71158599
16	electron transport chain (GO:0022900)	3.69505650
17	protein neddylation (GO:0045116)	3.68864754
18	response to pheromone (GO:0019236)	3.67739354
19	negative regulation of mast cell activation (GO:0033004)	3.66882479
20	negative regulation of execution phase of apoptosis (GO:1900118)	3.66068461
21	cellular response to exogenous dsRNA (GO:0071360)	3.62350609
22	behavioral response to nicotine (GO:0035095)	3.58034771
23	activated T cell proliferation (GO:0050798)	3.44414160
24	branched-chain amino acid metabolic process (GO:0009081)	3.40845921
25	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.37201185
26	GMP metabolic process (GO:0046037)	3.36535064
27	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.33632944
28	amino acid salvage (GO:0043102)	3.29237045
29	L-methionine salvage (GO:0071267)	3.29237045
30	L-methionine biosynthetic process (GO:0071265)	3.29237045
31	protein-cofactor linkage (GO:0018065)	3.25577856
32	preassembly of GPI anchor in ER membrane (GO:0016254)	3.24177273
33	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.22814257
34	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.22129564
35	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.22129564
36	ATP biosynthetic process (GO:0006754)	3.21948854
37	positive regulation of protein homooligomerization (GO:0032464)	3.21851139
38	metallo-sulfur cluster assembly (GO:0031163)	3.20494799
39	iron-sulfur cluster assembly (GO:0016226)	3.20494799
40	retinal cone cell development (GO:0046549)	3.20327308
41	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.19987700
42	positive regulation of mitochondrial fission (GO:0090141)	3.14422063
43	xenobiotic catabolic process (GO:0042178)	3.14116133
44	cytolysis (GO:0019835)	3.12165775
45	negative regulation of cation channel activity (GO:2001258)	3.11412696
46	female mating behavior (GO:0060180)	3.10370973
47	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	3.06721717
48	negative regulation of heart rate (GO:0010459)	3.05128498
49	regulation of cellular amino acid metabolic process (GO:0006521)	3.00052449
50	branched-chain amino acid catabolic process (GO:0009083)	2.98363450
51	protein complex biogenesis (GO:0070271)	2.97570735
52	NADH dehydrogenase complex assembly (GO:0010257)	2.96514165
53	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.96514165
54	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.96514165
55	methionine biosynthetic process (GO:0009086)	2.95497159
56	mannosylation (GO:0097502)	2.93881825
57	S-adenosylmethionine metabolic process (GO:0046500)	2.92370510
58	mismatch repair (GO:0006298)	2.89268604
59	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.86639472
60	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.86639472
61	proteasome assembly (GO:0043248)	2.86041154
62	pyridine nucleotide biosynthetic process (GO:0019363)	2.85131254
63	nicotinamide nucleotide biosynthetic process (GO:0019359)	2.85131254
64	regulation of catecholamine metabolic process (GO:0042069)	2.83357738
65	regulation of dopamine metabolic process (GO:0042053)	2.83357738
66	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.80945212
67	T cell migration (GO:0072678)	2.80882368
68	indole-containing compound catabolic process (GO:0042436)	2.78000030
69	indolalkylamine catabolic process (GO:0046218)	2.78000030
70	tryptophan catabolic process (GO:0006569)	2.78000030
71	negative regulation of telomere maintenance (GO:0032205)	2.77035059
72	negative regulation of calcium ion transmembrane transport (GO:1903170)	2.76655195
73	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	2.76655195
74	parturition (GO:0007567)	2.73730933
75	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.72232689
76	nucleotide-excision repair, DNA damage removal (GO:0000718)	2.71836939
77	DNA excision (GO:0044349)	2.71836939
78	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.71586817
79	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.71586817
80	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.71586817
81	isoprenoid biosynthetic process (GO:0008299)	2.70216400
82	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.68794038
83	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.68794038
84	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.67645143
85	aggressive behavior (GO:0002118)	2.64793663
86	sequestering of actin monomers (GO:0042989)	2.64437969
87	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	2.61389544
88	mitochondrial respiratory chain complex assembly (GO:0033108)	2.59307636
89	kynurenine metabolic process (GO:0070189)	2.58516585
90	cytidine deamination (GO:0009972)	2.58431667
91	cytidine metabolic process (GO:0046087)	2.58431667
92	cytidine catabolic process (GO:0006216)	2.58431667
93	hydrogen ion transmembrane transport (GO:1902600)	2.58407873
94	aldehyde catabolic process (GO:0046185)	2.57338875
95	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.55390259
96	pyrimidine nucleotide catabolic process (GO:0006244)	2.55153849
97	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.55003635
98	regulation of female receptivity (GO:0045924)	2.54900533
99	positive regulation of defense response to virus by host (GO:0002230)	2.53923491
100	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.53591248

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.85813103
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.84769868
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.76065791
4	VDR_22108803_ChIP-Seq_LS180_Human	3.21147790
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.16304226
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.86004132
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.78612257
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.38947213
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.30695322
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.28918473
11	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.22895122
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.20822648
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.18783357
14	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	2.11478619
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.08678821
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.08268041
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.06593918
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.06004014
19	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.94525293
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.94492524
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.93938838
22	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.93725751
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.92987156
24	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.90353904
25	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.86818792
26	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.86621112
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.83738409
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.83038888
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.77476664
30	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.73471211
31	FUS_26573619_Chip-Seq_HEK293_Human	1.72538175
32	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.68801634
33	EWS_26573619_Chip-Seq_HEK293_Human	1.66198984
34	EZH2_22144423_ChIP-Seq_EOC_Human	1.60927501
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.58017095
36	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.56263921
37	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.54868377
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.54687850
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54687850
40	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.53986281
41	P300_19829295_ChIP-Seq_ESCs_Human	1.50269812
42	TP53_22573176_ChIP-Seq_HFKS_Human	1.49409574
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.49402946
44	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.49288068
45	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.48694681
46	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.45703897
47	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.36218388
48	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.34250552
49	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.33678581
50	MYC_18940864_ChIP-ChIP_HL60_Human	1.32414537
51	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.30555189
52	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.29047952
53	OCT4_20526341_ChIP-Seq_ESCs_Human	1.27186401
54	GBX2_23144817_ChIP-Seq_PC3_Human	1.24883729
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24548352
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24548352
57	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.24315650
58	NCOR_22424771_ChIP-Seq_293T_Human	1.20103261
59	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.19139590
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18803696
61	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.18199587
62	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.18150916
63	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.16832610
64	TAF2_19829295_ChIP-Seq_ESCs_Human	1.15087669
65	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14162575
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09828831
67	ERA_21632823_ChIP-Seq_H3396_Human	1.09411378
68	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07887131
69	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06567889
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.05933758
71	AR_20517297_ChIP-Seq_VCAP_Human	1.05854658
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.05311883
73	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.03643586
74	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03516670
75	GATA3_26560356_Chip-Seq_TH2_Human	1.03210067
76	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03099685
77	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.01603844
78	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.01367261
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99816947
80	BCAT_22108803_ChIP-Seq_LS180_Human	0.99336845
81	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97802975
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97183813
83	CIITA_25753668_ChIP-Seq_RAJI_Human	0.96739207
84	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96377728
85	GABP_19822575_ChIP-Seq_HepG2_Human	0.95905670
86	REST_21632747_ChIP-Seq_MESCs_Mouse	0.94279544
87	HTT_18923047_ChIP-ChIP_STHdh_Human	0.94180000
88	SOX2_19829295_ChIP-Seq_ESCs_Human	0.93625377
89	NANOG_19829295_ChIP-Seq_ESCs_Human	0.93625377
90	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.92597458
91	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.92465767
92	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.91590006
93	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.91328014
94	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.90940828
95	SMAD4_21799915_ChIP-Seq_A2780_Human	0.90675085
96	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.89933932
97	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.88709365
98	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.88258858
99	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.86727798
100	PHF8_20622853_ChIP-Seq_HELA_Human	0.86616931

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003011_delayed_dark_adaptation	4.52510904
2	MP0008877_abnormal_DNA_methylation	3.82645624
3	MP0002736_abnormal_nociception_after	3.42051038
4	MP0005671_abnormal_response_to	3.41729058
5	MP0004145_abnormal_muscle_electrophysio	3.00221229
6	MP0004147_increased_porphyrin_level	2.83403417
7	MP0002837_dystrophic_cardiac_calcinosis	2.77058500
8	MP0003787_abnormal_imprinting	2.75378731
9	MP0001968_abnormal_touch/_nociception	2.67644633
10	MP0001727_abnormal_embryo_implantation	2.37423678
11	MP0008058_abnormal_DNA_repair	2.18948301
12	MP0005646_abnormal_pituitary_gland	2.13373529
13	MP0005645_abnormal_hypothalamus_physiol	2.08559286
14	MP0002254_reproductive_system_inflammat	2.06670543
15	MP0001905_abnormal_dopamine_level	2.01851093
16	MP0002876_abnormal_thyroid_physiology	1.97014445
17	MP0004885_abnormal_endolymph	1.85253690
18	MP0002090_abnormal_vision	1.85003155
19	MP0005551_abnormal_eye_electrophysiolog	1.82700550
20	MP0003866_abnormal_defecation	1.78558814
21	MP0003137_abnormal_impulse_conducting	1.75558238
22	MP0002909_abnormal_adrenal_gland	1.74984315
23	MP0001764_abnormal_homeostasis	1.70727669
24	MP0008875_abnormal_xenobiotic_pharmacok	1.70586641
25	MP0005253_abnormal_eye_physiology	1.67783191
26	MP0005423_abnormal_somatic_nervous	1.67287578
27	MP0002160_abnormal_reproductive_system	1.59623378
28	MP0008872_abnormal_physiological_respon	1.53656511
29	MP0006072_abnormal_retinal_apoptosis	1.53489224
30	MP0003950_abnormal_plasma_membrane	1.45743971
31	MP0005084_abnormal_gallbladder_morpholo	1.45686253
32	MP0006276_abnormal_autonomic_nervous	1.40152129
33	MP0005085_abnormal_gallbladder_physiolo	1.39676033
34	MP0005647_abnormal_sex_gland	1.36593174
35	MP0002272_abnormal_nervous_system	1.36300166
36	MP0005389_reproductive_system_phenotype	1.30889982
37	MP0005167_abnormal_blood-brain_barrier	1.30144386
38	MP0005379_endocrine/exocrine_gland_phen	1.29858639
39	MP0006036_abnormal_mitochondrial_physio	1.28479270
40	MP0003880_abnormal_central_pattern	1.27349226
41	MP0001486_abnormal_startle_reflex	1.26177668
42	MP0003195_calcinosis	1.24758654
43	MP0006035_abnormal_mitochondrial_morpho	1.24278942
44	MP0002822_catalepsy	1.23535152
45	MP0002928_abnormal_bile_duct	1.22723651
46	MP0002166_altered_tumor_susceptibility	1.21220446
47	MP0001502_abnormal_circadian_rhythm	1.18556887
48	MP0009785_altered_susceptibility_to	1.17461898
49	MP0001440_abnormal_grooming_behavior	1.17240489
50	MP0009697_abnormal_copulation	1.14947360
51	MP0001919_abnormal_reproductive_system	1.14911953
52	MP0002557_abnormal_social/conspecific_i	1.13522767
53	MP0002138_abnormal_hepatobiliary_system	1.10407014
54	MP0005410_abnormal_fertilization	1.09208763
55	MP0004742_abnormal_vestibular_system	1.08576662
56	MP0002006_tumorigenesis	1.05553211
57	MP0002139_abnormal_hepatobiliary_system	1.05434237
58	MP0002102_abnormal_ear_morphology	1.05009178
59	MP0009745_abnormal_behavioral_response	1.04178487
60	MP0005332_abnormal_amino_acid	1.03600532
61	MP0002733_abnormal_thermal_nociception	1.03387842
62	MP0003718_maternal_effect	1.02978832
63	MP0002148_abnormal_hypersensitivity_rea	1.01219697
64	MP0001970_abnormal_pain_threshold	0.99299141
65	MP0002572_abnormal_emotion/affect_behav	0.98770581
66	MP0009046_muscle_twitch	0.98529968
67	MP0002277_abnormal_respiratory_mucosa	0.96477847
68	MP0002693_abnormal_pancreas_physiology	0.95115861
69	MP0000631_abnormal_neuroendocrine_gland	0.94768277
70	MP0000639_abnormal_adrenal_gland	0.94011390
71	MP0005166_decreased_susceptibility_to	0.93882432
72	MP0002064_seizures	0.90913333
73	MP0002638_abnormal_pupillary_reflex	0.89902308
74	MP0001348_abnormal_lacrimal_gland	0.87909841
75	MP0006292_abnormal_olfactory_placode	0.85868823
76	MP0002067_abnormal_sensory_capabilities	0.85351148
77	MP0001929_abnormal_gametogenesis	0.84870116
78	MP0005195_abnormal_posterior_eye	0.83610570
79	MP0000230_abnormal_systemic_arterial	0.82644657
80	MP0005395_other_phenotype	0.82638048
81	MP0003045_fibrosis	0.80856837
82	MP0006082_CNS_inflammation	0.79635162
83	MP0002063_abnormal_learning/memory/cond	0.79501163
84	MP0002168_other_aberrant_phenotype	0.79067357
85	MP0009643_abnormal_urine_homeostasis	0.76464139
86	MP0002210_abnormal_sex_determination	0.75511517
87	MP0003698_abnormal_male_reproductive	0.75471716
88	MP0008789_abnormal_olfactory_epithelium	0.75467431
89	MP0002163_abnormal_gland_morphology	0.74740217
90	MP0002184_abnormal_innervation	0.72705327
91	MP0003567_abnormal_fetal_cardiomyocyte	0.72633787
92	MP0005535_abnormal_body_temperature	0.72050970
93	MP0001485_abnormal_pinna_reflex	0.71990274
94	MP0003252_abnormal_bile_duct	0.71769768
95	MP0002229_neurodegeneration	0.71394921
96	MP0000653_abnormal_sex_gland	0.70796309
97	MP0001835_abnormal_antigen_presentation	0.70698296
98	MP0003635_abnormal_synaptic_transmissio	0.69865764
99	MP0001145_abnormal_male_reproductive	0.69594728
100	MP0001984_abnormal_olfaction	0.68478232

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Visual hallucinations (HP:0002367)	5.02791113
2	Acute necrotizing encephalopathy (HP:0006965)	3.88601940
3	3-Methylglutaconic aciduria (HP:0003535)	3.79903574
4	Increased neuronal autofluorescent lipopigment (HP:0002074)	3.71805513
5	Congenital stationary night blindness (HP:0007642)	3.66181892
6	Autoimmune hemolytic anemia (HP:0001890)	3.59550337
7	Gout (HP:0001997)	3.57551614
8	Acute encephalopathy (HP:0006846)	3.51216269
9	Progressive macrocephaly (HP:0004481)	3.45780497
10	Testicular atrophy (HP:0000029)	3.45600057
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.40964761
12	Autoimmune thrombocytopenia (HP:0001973)	3.38501481
13	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.38500837
14	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.38500837
15	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	3.37368629
16	Pancreatic cysts (HP:0001737)	3.34734039
17	Proximal tubulopathy (HP:0000114)	3.26465586
18	Pancreatic fibrosis (HP:0100732)	3.26066223
19	True hermaphroditism (HP:0010459)	3.24914456
20	Mitochondrial inheritance (HP:0001427)	3.15285808
21	Methylmalonic acidemia (HP:0002912)	3.13555807
22	Cerebral edema (HP:0002181)	3.10606601
23	Prostate neoplasm (HP:0100787)	3.09377493
24	Renal cortical cysts (HP:0000803)	3.00863426
25	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.97223066
26	Abnormal protein N-linked glycosylation (HP:0012347)	2.97223066
27	Abnormal protein glycosylation (HP:0012346)	2.97223066
28	Abnormal glycosylation (HP:0012345)	2.97223066
29	Hypoglycemic coma (HP:0001325)	2.94238795
30	Increased cerebral lipofuscin (HP:0011813)	2.91057390
31	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.83525748
32	Hypoproteinemia (HP:0003075)	2.70855896
33	Type I transferrin isoform profile (HP:0003642)	2.67674855
34	Tetraparesis (HP:0002273)	2.65313677
35	Abnormality of purine metabolism (HP:0004352)	2.59980977
36	Cerebral palsy (HP:0100021)	2.57055848
37	Asplenia (HP:0001746)	2.56003304
38	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.54852876
39	Increased CSF lactate (HP:0002490)	2.48567369
40	Aplastic anemia (HP:0001915)	2.46390889
41	Late onset (HP:0003584)	2.38900341
42	Abnormality of T cell physiology (HP:0011840)	2.36293844
43	Ketosis (HP:0001946)	2.35969761
44	Lethargy (HP:0001254)	2.33809399
45	Abnormality of the renal cortex (HP:0011035)	2.33027765
46	Abnormality of midbrain morphology (HP:0002418)	2.30095459
47	Molar tooth sign on MRI (HP:0002419)	2.30095459
48	Pendular nystagmus (HP:0012043)	2.27548053
49	Lactic acidosis (HP:0003128)	2.27279679
50	Methylmalonic aciduria (HP:0012120)	2.26937980
51	Cerebral hypomyelination (HP:0006808)	2.25045148
52	Abnormality of the prostate (HP:0008775)	2.23568252
53	Hyperinsulinemic hypoglycemia (HP:0000825)	2.22648725
54	Abnormality of vitamin B metabolism (HP:0004340)	2.20144078
55	Hepatic necrosis (HP:0002605)	2.19629290
56	Ketoacidosis (HP:0001993)	2.19340950
57	Parakeratosis (HP:0001036)	2.19222626
58	Abnormality of T cells (HP:0002843)	2.15012777
59	Hypomagnesemia (HP:0002917)	2.14593469
60	Adrenal hypoplasia (HP:0000835)	2.13459307
61	Pustule (HP:0200039)	2.12160733
62	Chorioretinal atrophy (HP:0000533)	2.11610485
63	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.10890963
64	Abolished electroretinogram (ERG) (HP:0000550)	2.07182453
65	Opisthotonus (HP:0002179)	2.07105843
66	Symptomatic seizures (HP:0011145)	2.05819760
67	Abnormality of serum amino acid levels (HP:0003112)	2.01826075
68	Cystic liver disease (HP:0006706)	2.01780569
69	Abnormal pancreas size (HP:0012094)	1.99862873
70	Type II lissencephaly (HP:0007260)	1.99775621
71	Decreased central vision (HP:0007663)	1.96301995
72	Optic disc pallor (HP:0000543)	1.95174923
73	Furrowed tongue (HP:0000221)	1.93318799
74	Hyperglycinemia (HP:0002154)	1.90510087
75	Focal motor seizures (HP:0011153)	1.90218495
76	Abnormality of magnesium homeostasis (HP:0004921)	1.90043015
77	Nephrogenic diabetes insipidus (HP:0009806)	1.89318853
78	Generalized aminoaciduria (HP:0002909)	1.88217826
79	Abnormal rod and cone electroretinograms (HP:0008323)	1.86500128
80	Increased hepatocellular lipid droplets (HP:0006565)	1.86438212
81	IgG deficiency (HP:0004315)	1.85360642
82	Spastic diplegia (HP:0001264)	1.85082058
83	Respiratory failure (HP:0002878)	1.84035527
84	Dicarboxylic aciduria (HP:0003215)	1.82571816
85	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.82571816
86	Large for gestational age (HP:0001520)	1.81919968
87	Abnormality of placental membranes (HP:0011409)	1.78804352
88	Amniotic constriction ring (HP:0009775)	1.78804352
89	Sclerocornea (HP:0000647)	1.78266888
90	Hypoalbuminemia (HP:0003073)	1.77402191
91	Abnormal albumin level (HP:0012116)	1.77402191
92	Abnormality of methionine metabolism (HP:0010901)	1.76343834
93	Pancytopenia (HP:0001876)	1.76094140
94	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.75412771
95	Oral leukoplakia (HP:0002745)	1.74905014
96	Nephronophthisis (HP:0000090)	1.74396509
97	Renal Fanconi syndrome (HP:0001994)	1.74295039
98	Chronic hepatic failure (HP:0100626)	1.74111073
99	Medial flaring of the eyebrow (HP:0010747)	1.73664825
100	Male pseudohermaphroditism (HP:0000037)	1.72249166

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAF1	4.49734205
2	FRK	3.14711363
3	NEK1	2.85570216
4	VRK2	2.75514758
5	ADRBK2	2.68444571
6	MKNK1	2.52574309
7	MST4	2.45367923
8	EIF2AK3	2.29891398
9	VRK1	2.28018433
10	ZAK	2.17837829
11	GRK1	2.10695586
12	BRSK2	1.90671543
13	BCKDK	1.90220109
14	TNIK	1.87461620
15	MAPKAPK5	1.87318977
16	GRK7	1.80918680
17	TXK	1.74794791
18	GRK5	1.73457154
19	MAP4K1	1.61295337
20	DYRK3	1.56801517
21	BMPR2	1.50298386
22	DAPK2	1.49851398
23	BRSK1	1.45616491
24	ACVR1B	1.36689059
25	CAMKK2	1.34344754
26	KDR	1.23248918
27	CASK	1.18497388
28	PINK1	1.17755299
29	NUAK1	1.17535012
30	PHKG2	1.15500154
31	PHKG1	1.15500154
32	TLK1	1.15418708
33	WEE1	1.15308527
34	MAP3K12	1.08681941
35	BUB1	1.07687497
36	TAOK3	1.03276442
37	CSNK1G3	1.03121737
38	CSNK1A1L	1.00158631
39	PLK3	0.99756404
40	STK39	0.98866836
41	DAPK1	0.96010694
42	WNK3	0.94879511
43	CAMK2D	0.94705355
44	TIE1	0.92238616
45	MAP4K2	0.89563993
46	MAPK13	0.88913122
47	MAP3K4	0.87640363
48	MYLK	0.87510702
49	CSNK1G2	0.85942179
50	ITK	0.84226102
51	PRKCI	0.84043138
52	AKT3	0.79236801
53	FES	0.78388277
54	TNK2	0.78324400
55	MAP2K7	0.78023870
56	MAP3K11	0.77949600
57	IRAK4	0.77687562
58	ERBB3	0.71841547
59	CAMK2A	0.70254025
60	PRKCG	0.69739177
61	WNK4	0.67009307
62	BMPR1B	0.65496267
63	CSNK1G1	0.65447214
64	BTK	0.64570291
65	PRKCH	0.61414913
66	OXSR1	0.60871030
67	PAK3	0.59979133
68	MINK1	0.59298855
69	ADRBK1	0.59161771
70	INSRR	0.57793860
71	PRKCQ	0.57433908
72	RPS6KA5	0.55523299
73	PRKCE	0.54915435
74	PLK1	0.53518086
75	GRK6	0.52237538
76	RPS6KB1	0.52077148
77	CAMK2G	0.50980972
78	MKNK2	0.50047975
79	CSNK2A1	0.50043124
80	NEK9	0.49870830
81	FLT3	0.49760684
82	CSNK1A1	0.48781836
83	JAK3	0.48680891
84	FGFR2	0.48062199
85	CSNK2A2	0.47963007
86	IGF1R	0.47953312
87	PLK2	0.45892097
88	MARK1	0.45470921
89	FER	0.45447877
90	AURKA	0.44889368
91	NME2	0.43604578
92	STK10	0.43076747
93	EIF2AK1	0.43031993
94	DAPK3	0.42527650
95	PRKACA	0.40781981
96	SRPK1	0.40386753
97	LYN	0.40027865
98	STK38L	0.39841083
99	BRAF	0.39112964
100	MOS	0.37013981

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.76640251
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.46506192
3	Parkinsons disease_Homo sapiens_hsa05012	3.23696358
4	Mismatch repair_Homo sapiens_hsa03430	2.60659720
5	Protein export_Homo sapiens_hsa03060	2.59363469
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.52909039
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.43828484
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.41606985
9	Alzheimers disease_Homo sapiens_hsa05010	2.12296724
10	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.02240771
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.00065525
12	Huntingtons disease_Homo sapiens_hsa05016	1.84403160
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.78684355
14	Nucleotide excision repair_Homo sapiens_hsa03420	1.75734658
15	One carbon pool by folate_Homo sapiens_hsa00670	1.72901134
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.72722698
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.69679959
18	Phototransduction_Homo sapiens_hsa04744	1.69369984
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.68381022
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.66430929
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.61802197
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.53564519
23	Propanoate metabolism_Homo sapiens_hsa00640	1.50040617
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.48945753
25	Regulation of autophagy_Homo sapiens_hsa04140	1.40081611
26	Peroxisome_Homo sapiens_hsa04146	1.39513193
27	Caffeine metabolism_Homo sapiens_hsa00232	1.34910581
28	Ribosome_Homo sapiens_hsa03010	1.30458055
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.29459469
30	Antigen processing and presentation_Homo sapiens_hsa04612	1.29101665
31	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.28522039
32	Basal transcription factors_Homo sapiens_hsa03022	1.27773408
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.26067263
34	RNA polymerase_Homo sapiens_hsa03020	1.25846858
35	Asthma_Homo sapiens_hsa05310	1.20719307
36	Homologous recombination_Homo sapiens_hsa03440	1.19454880
37	Type I diabetes mellitus_Homo sapiens_hsa04940	1.16976468
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.15400536
39	Retinol metabolism_Homo sapiens_hsa00830	1.15076862
40	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.13508262
41	Butanoate metabolism_Homo sapiens_hsa00650	1.12406646
42	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.07613668
43	Tryptophan metabolism_Homo sapiens_hsa00380	1.05751361
44	Spliceosome_Homo sapiens_hsa03040	1.03305916
45	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.01712947
46	Graft-versus-host disease_Homo sapiens_hsa05332	1.01162367
47	Purine metabolism_Homo sapiens_hsa00230	1.00659392
48	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.00510781
49	Allograft rejection_Homo sapiens_hsa05330	0.97604036
50	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.95483508
51	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95182511
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.91637498
53	Base excision repair_Homo sapiens_hsa03410	0.87811138
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.85375822
55	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.84697586
56	Insulin secretion_Homo sapiens_hsa04911	0.81336453
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.81206973
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.79836457
59	RNA degradation_Homo sapiens_hsa03018	0.79386561
60	DNA replication_Homo sapiens_hsa03030	0.78108190
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75404576
62	Sulfur metabolism_Homo sapiens_hsa00920	0.75330946
63	Folate biosynthesis_Homo sapiens_hsa00790	0.71909181
64	Metabolic pathways_Homo sapiens_hsa01100	0.69627011
65	Steroid biosynthesis_Homo sapiens_hsa00100	0.68304857
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66475206
67	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.64511139
68	RNA transport_Homo sapiens_hsa03013	0.61669987
69	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.58040148
70	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.56761501
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55853712
72	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.55675698
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.55477784
74	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.55461896
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.54259923
76	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.53623374
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53412278
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.51952083
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51193453
80	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.50985954
81	Arginine biosynthesis_Homo sapiens_hsa00220	0.49322855
82	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49226026
83	Taste transduction_Homo sapiens_hsa04742	0.46075033
84	Mineral absorption_Homo sapiens_hsa04978	0.45343626
85	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.45088852
86	Olfactory transduction_Homo sapiens_hsa04740	0.43531106
87	Long-term depression_Homo sapiens_hsa04730	0.41140790
88	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.40246399
89	Tyrosine metabolism_Homo sapiens_hsa00350	0.40129013
90	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.38903533
91	Pyruvate metabolism_Homo sapiens_hsa00620	0.38837324
92	Rheumatoid arthritis_Homo sapiens_hsa05323	0.38710527
93	Serotonergic synapse_Homo sapiens_hsa04726	0.38415766
94	Non-homologous end-joining_Homo sapiens_hsa03450	0.37769899
95	Fanconi anemia pathway_Homo sapiens_hsa03460	0.35361297
96	Cocaine addiction_Homo sapiens_hsa05030	0.34539280
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.34288633
98	Renin secretion_Homo sapiens_hsa04924	0.33203595
99	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.32042319
100	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.32014403

ATP5F1P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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