ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	urate metabolic process (GO:0046415)	6.36596858
2	regulation of skeletal muscle contraction (GO:0014819)	4.88333569
3	purine-containing compound salvage (GO:0043101)	4.46842531
4	activated T cell proliferation (GO:0050798)	4.40625651
5	skeletal muscle tissue regeneration (GO:0043403)	4.33715001
6	negative regulation of heart rate (GO:0010459)	4.32451258
7	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	4.25302076
8	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.19720889
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.16566473
10	ATP synthesis coupled proton transport (GO:0015986)	4.16522339
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.16522339
12	response to gravity (GO:0009629)	4.15675132
13	male meiosis I (GO:0007141)	3.95406354
14	production of molecular mediator involved in inflammatory response (GO:0002532)	3.90068382
15	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.84467965
16	behavioral response to nicotine (GO:0035095)	3.67415974
17	cellular response to exogenous dsRNA (GO:0071360)	3.60394088
18	pyrimidine dimer repair (GO:0006290)	3.57331671
19	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.53265299
20	negative regulation of phosphoprotein phosphatase activity (GO:0032515)	3.49819398
21	regulation of DNA methylation (GO:0044030)	3.48256824
22	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.48001546
23	nucleotide-sugar biosynthetic process (GO:0009226)	3.44400889
24	regulation of chronic inflammatory response (GO:0002676)	3.43309774
25	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.40575918
26	positive regulation of histone H3-K4 methylation (GO:0051571)	3.38367409
27	skeletal muscle adaptation (GO:0043501)	3.37608612
28	positive regulation of defense response to virus by host (GO:0002230)	3.33817962
29	DNA deamination (GO:0045006)	3.32355355
30	protein homotrimerization (GO:0070207)	3.32057242
31	regulation of female gonad development (GO:2000194)	3.28831479
32	striated muscle atrophy (GO:0014891)	3.28639332
33	spermatid nucleus differentiation (GO:0007289)	3.23492507
34	rRNA modification (GO:0000154)	3.22727442
35	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.19861713
36	grooming behavior (GO:0007625)	3.13770106
37	positive regulation of steroid hormone secretion (GO:2000833)	3.09960316
38	positive regulation of protein homooligomerization (GO:0032464)	3.08558964
39	regulation of immunoglobulin secretion (GO:0051023)	3.07506530
40	regulation of acrosome reaction (GO:0060046)	3.07458636
41	ribosomal large subunit biogenesis (GO:0042273)	3.05223967
42	lipoxygenase pathway (GO:0019372)	3.04513756
43	positive regulation of prostaglandin secretion (GO:0032308)	3.03075906
44	chaperone-mediated protein transport (GO:0072321)	3.02692137
45	negative regulation of muscle hypertrophy (GO:0014741)	3.01937214
46	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.99149908
47	cytolysis (GO:0019835)	2.98420320
48	positive regulation of interleukin-17 production (GO:0032740)	2.96832731
49	positive regulation of protein homodimerization activity (GO:0090073)	2.94910710
50	regulation of dopamine metabolic process (GO:0042053)	2.94651384
51	regulation of catecholamine metabolic process (GO:0042069)	2.94651384
52	multicellular organism reproduction (GO:0032504)	2.94181692
53	negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)	2.92618162
54	pseudouridine synthesis (GO:0001522)	2.91555223
55	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.90865028
56	NAD biosynthetic process (GO:0009435)	2.89479363
57	meiosis I (GO:0007127)	2.89089558
58	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.88458799
59	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.84061363
60	purine nucleotide salvage (GO:0032261)	2.83508632
61	motile cilium assembly (GO:0044458)	2.77389731
62	cytidine deamination (GO:0009972)	2.77126923
63	cytidine metabolic process (GO:0046087)	2.77126923
64	cytidine catabolic process (GO:0006216)	2.77126923
65	regulation of isotype switching to IgG isotypes (GO:0048302)	2.74024989
66	regulation of steroid hormone secretion (GO:2000831)	2.73477124
67	regulation of prostaglandin secretion (GO:0032306)	2.72837548
68	acrosome assembly (GO:0001675)	2.71712413
69	regulation of hypersensitivity (GO:0002883)	2.71592125
70	GDP-mannose metabolic process (GO:0019673)	2.70029221
71	leukotriene biosynthetic process (GO:0019370)	2.69581674
72	muscle atrophy (GO:0014889)	2.66529799
73	protein trimerization (GO:0070206)	2.64884725
74	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.64048665
75	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.60558350
76	response to pheromone (GO:0019236)	2.59934498
77	actin-myosin filament sliding (GO:0033275)	2.59650940
78	muscle filament sliding (GO:0030049)	2.59650940
79	protein K6-linked ubiquitination (GO:0085020)	2.57240347
80	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.56164281
81	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.56025962
82	proteasome assembly (GO:0043248)	2.55353192
83	negative regulation of cation channel activity (GO:2001258)	2.52982006
84	ATP biosynthetic process (GO:0006754)	2.51749225
85	mitochondrial DNA replication (GO:0006264)	2.50893586
86	regulation of defense response to virus by host (GO:0050691)	2.50374740
87	respiratory electron transport chain (GO:0022904)	2.49215008
88	negative regulation of calcium ion transmembrane transport (GO:1903170)	2.48216421
89	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	2.48216421
90	mitochondrial genome maintenance (GO:0000002)	2.47306269
91	regulation of meiosis I (GO:0060631)	2.44353586
92	regulation of regulatory T cell differentiation (GO:0045589)	2.43985982
93	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.43910719
94	electron transport chain (GO:0022900)	2.43358364
95	endocrine hormone secretion (GO:0060986)	2.40156455
96	aggressive behavior (GO:0002118)	2.40099768
97	protein sumoylation (GO:0016925)	2.38385299
98	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.37636714
99	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	18.3966814
100	regulation of retinoic acid receptor signaling pathway (GO:0048385)	15.4655987

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.66668799
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.23012171
3	VDR_22108803_ChIP-Seq_LS180_Human	3.89501659
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.26163902
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.22291665
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.73388707
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.64785289
8	GATA1_22025678_ChIP-Seq_K562_Human	2.63859932
9	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.55501869
10	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.50517401
11	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.44556619
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.44296603
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.27568644
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.25351388
15	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.18823921
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.15392389
17	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	2.14342069
18	ER_23166858_ChIP-Seq_MCF-7_Human	2.08616985
19	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.04872908
20	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.03754192
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.98930929
22	VDR_23849224_ChIP-Seq_CD4+_Human	1.93575222
23	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.86084146
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.84732508
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.81644196
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.80981778
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.78774927
28	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.78084359
29	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.72940694
30	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.71388643
31	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.69860668
32	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.69421679
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.60135793
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.53406533
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.53373287
36	CIITA_25753668_ChIP-Seq_RAJI_Human	1.50810091
37	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.48239683
38	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.47119232
39	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.45179410
40	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.42793245
41	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.41511603
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40152313
43	GBX2_23144817_ChIP-Seq_PC3_Human	1.36150548
44	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.36034021
45	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.32164663
46	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.31528674
47	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.30702120
48	EWS_26573619_Chip-Seq_HEK293_Human	1.30684057
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.27466902
50	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.26739933
51	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.25171286
52	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.24187661
53	GATA3_26560356_Chip-Seq_TH2_Human	1.21653024
54	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.20907221
55	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.17852760
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.13972894
57	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.12998179
58	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.11348593
59	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.11294073
60	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10897888
61	PHF8_20622853_ChIP-Seq_HELA_Human	1.10801155
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.09099625
63	P300_19829295_ChIP-Seq_ESCs_Human	1.08936958
64	NFYB_21822215_ChIP-Seq_K562_Human	1.08586524
65	NCOR_22424771_ChIP-Seq_293T_Human	1.08105412
66	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.08016400
67	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.07972379
68	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.07384483
69	ETV1_20927104_ChIP-Seq_GIST48_Human	1.04503261
70	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03144858
71	MYB_26560356_Chip-Seq_TH2_Human	1.02276808
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01605112
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01605112
74	RBPJ_21746931_ChIP-Seq_IB4_Human	1.01510676
75	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.01115813
76	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.99768974
77	FOXP3_21729870_ChIP-Seq_TREG_Human	0.99337351
78	SPI1_20517297_ChIP-Seq_HL60_Human	0.98755990
79	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.97739868
80	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.97060274
81	ELF5_23300383_ChIP-Seq_T47D_Human	0.95173402
82	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95003868
83	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.94983413
84	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.94443620
85	ERG_20517297_ChIP-Seq_VCAP_Human	0.92551297
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.90572195
87	TBL1_22424771_ChIP-Seq_293T_Human	0.90474700
88	CBP_20019798_ChIP-Seq_JUKART_Human	0.88985533
89	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.88985533
90	RAC3_21632823_ChIP-Seq_H3396_Human	0.88849725
91	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.87420649
92	HTT_18923047_ChIP-ChIP_STHdh_Human	0.87108585
93	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.86909324
94	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.86401877
95	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.86386531
96	BCAT_22108803_ChIP-Seq_LS180_Human	0.85947077
97	FUS_26573619_Chip-Seq_HEK293_Human	0.83879367
98	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.83382777
99	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.82872664
100	RNF2_27304074_Chip-Seq_NSC_Mouse	0.81542531

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005423_abnormal_somatic_nervous	5.46053430
2	MP0003880_abnormal_central_pattern	3.45461277
3	MP0005671_abnormal_response_to	3.22950907
4	MP0001986_abnormal_taste_sensitivity	3.09197897
5	MP0001348_abnormal_lacrimal_gland	3.07272897
6	MP0004147_increased_porphyrin_level	2.88261173
7	MP0003950_abnormal_plasma_membrane	2.82622211
8	MP0005645_abnormal_hypothalamus_physiol	2.76555574
9	MP0006292_abnormal_olfactory_placode	2.68933409
10	MP0008877_abnormal_DNA_methylation	2.67690614
11	MP0008057_abnormal_DNA_replication	2.45696461
12	MP0002138_abnormal_hepatobiliary_system	2.41562987
13	MP0001835_abnormal_antigen_presentation	2.35423331
14	MP0005647_abnormal_sex_gland	2.33305456
15	MP0002160_abnormal_reproductive_system	2.26057162
16	MP0000747_muscle_weakness	2.12241584
17	MP0003195_calcinosis	2.09796908
18	MP0001502_abnormal_circadian_rhythm	2.09168967
19	MP0002736_abnormal_nociception_after	2.06184752
20	MP0002254_reproductive_system_inflammat	2.04246096
21	MP0003718_maternal_effect	2.01008206
22	MP0004145_abnormal_muscle_electrophysio	1.99505442
23	MP0002090_abnormal_vision	1.88106191
24	MP0002876_abnormal_thyroid_physiology	1.76719607
25	MP0008058_abnormal_DNA_repair	1.72188994
26	MP0001968_abnormal_touch/_nociception	1.71075849
27	MP0009333_abnormal_splenocyte_physiolog	1.69252025
28	MP0003763_abnormal_thymus_physiology	1.67756261
29	MP0005389_reproductive_system_phenotype	1.64305717
30	MP0000749_muscle_degeneration	1.57384816
31	MP0001486_abnormal_startle_reflex	1.56418374
32	MP0006276_abnormal_autonomic_nervous	1.56132883
33	MP0000372_irregular_coat_pigmentation	1.51232873
34	MP0001873_stomach_inflammation	1.41312743
35	MP0002210_abnormal_sex_determination	1.39664317
36	MP0010094_abnormal_chromosome_stability	1.38952339
37	MP0003111_abnormal_nucleus_morphology	1.31744438
38	MP0010307_abnormal_tumor_latency	1.26000697
39	MP0002751_abnormal_autonomic_nervous	1.25364253
40	MP0001919_abnormal_reproductive_system	1.23753963
41	MP0003786_premature_aging	1.19416607
42	MP0005620_abnormal_muscle_contractility	1.19125177
43	MP0005551_abnormal_eye_electrophysiolog	1.14616068
44	MP0003959_abnormal_lean_body	1.12976971
45	MP0002269_muscular_atrophy	1.11421452
46	MP0004215_abnormal_myocardial_fiber	1.11132464
47	MP0001929_abnormal_gametogenesis	1.06762981
48	MP0005395_other_phenotype	1.06475774
49	MP0009785_altered_susceptibility_to	1.05357579
50	MP0004142_abnormal_muscle_tone	1.04479664
51	MP0000653_abnormal_sex_gland	1.03990488
52	MP0002006_tumorigenesis	1.03516063
53	MP0003045_fibrosis	1.02388058
54	MP0002166_altered_tumor_susceptibility	0.99421554
55	MP0000685_abnormal_immune_system	0.97961952
56	MP0002277_abnormal_respiratory_mucosa	0.97714237
57	MP0004036_abnormal_muscle_relaxation	0.97018671
58	MP0001119_abnormal_female_reproductive	0.96451123
59	MP0003866_abnormal_defecation	0.95596376
60	MP0005310_abnormal_salivary_gland	0.94967051
61	MP0001346_abnormal_lacrimal_gland	0.93586758
62	MP0005646_abnormal_pituitary_gland	0.91592620
63	MP0003137_abnormal_impulse_conducting	0.90604465
64	MP0003077_abnormal_cell_cycle	0.89760451
65	MP0005167_abnormal_blood-brain_barrier	0.88613336
66	MP0009046_muscle_twitch	0.87218688
67	MP0001145_abnormal_male_reproductive	0.86762992
68	MP0005410_abnormal_fertilization	0.86240371
69	MP0006072_abnormal_retinal_apoptosis	0.85713418
70	MP0008775_abnormal_heart_ventricle	0.84260866
71	MP0006035_abnormal_mitochondrial_morpho	0.84028235
72	MP0003567_abnormal_fetal_cardiomyocyte	0.83947348
73	MP0003283_abnormal_digestive_organ	0.82383742
74	MP0004019_abnormal_vitamin_homeostasis	0.80760518
75	MP0002148_abnormal_hypersensitivity_rea	0.79337697
76	MP0002272_abnormal_nervous_system	0.79278047
77	MP0002638_abnormal_pupillary_reflex	0.77337879
78	MP0002067_abnormal_sensory_capabilities	0.76811702
79	MP0002064_seizures	0.75917841
80	MP0009745_abnormal_behavioral_response	0.75640786
81	MP0005253_abnormal_eye_physiology	0.75408639
82	MP0000427_abnormal_hair_cycle	0.75155650
83	MP0008872_abnormal_physiological_respon	0.73956488
84	MP0000631_abnormal_neuroendocrine_gland	0.73266815
85	MP0002127_abnormal_cardiovascular_syste	0.71900300
86	MP0002089_abnormal_postnatal_growth/wei	0.71389954
87	MP0002420_abnormal_adaptive_immunity	0.70504845
88	MP0003436_decreased_susceptibility_to	0.70426855
89	MP0010368_abnormal_lymphatic_system	0.68071433
90	MP0003698_abnormal_male_reproductive	0.67626990
91	MP0001819_abnormal_immune_cell	0.67410269
92	MP0000759_abnormal_skeletal_muscle	0.67334406
93	MP0003699_abnormal_female_reproductive	0.65898749
94	MP0001790_abnormal_immune_system	0.65896808
95	MP0005387_immune_system_phenotype	0.65896808
96	MP0004957_abnormal_blastocyst_morpholog	0.65421583
97	MP0005000_abnormal_immune_tolerance	0.64014886
98	MP0002837_dystrophic_cardiac_calcinosis	0.62823322
99	MP0001440_abnormal_grooming_behavior	0.62567225
100	MP0000733_abnormal_muscle_development	0.62313806

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Testicular atrophy (HP:0000029)	7.33201590
2	Visual hallucinations (HP:0002367)	7.01052801
3	Autoimmune hemolytic anemia (HP:0001890)	6.60674574
4	Autoimmune thrombocytopenia (HP:0001973)	6.07953704
5	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	5.28627171
6	Increased neuronal autofluorescent lipopigment (HP:0002074)	5.07801350
7	Tetraparesis (HP:0002273)	5.03465977
8	Prostate neoplasm (HP:0100787)	4.58881094
9	Increased cerebral lipofuscin (HP:0011813)	4.11404161
10	Male infertility (HP:0003251)	3.70554342
11	Dyschromatopsia (HP:0007641)	3.27810579
12	Abnormality of purine metabolism (HP:0004352)	3.15514986
13	Abnormality of the prostate (HP:0008775)	3.14991442
14	Central scotoma (HP:0000603)	3.11018049
15	Short tibia (HP:0005736)	3.09520685
16	Spastic diplegia (HP:0001264)	3.01089640
17	Congenital stationary night blindness (HP:0007642)	2.99752414
18	Supernumerary spleens (HP:0009799)	2.95063274
19	Insidious onset (HP:0003587)	2.93025715
20	Termporal pattern (HP:0011008)	2.93025715
21	Gout (HP:0001997)	2.90036642
22	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.82116426
23	Abnormal auditory evoked potentials (HP:0006958)	2.81237293
24	Parakeratosis (HP:0001036)	2.76861355
25	Fibular aplasia (HP:0002990)	2.72903065
26	3-Methylglutaconic aciduria (HP:0003535)	2.69946703
27	Malnutrition (HP:0004395)	2.69506615
28	Progressive external ophthalmoplegia (HP:0000590)	2.69062222
29	Azoospermia (HP:0000027)	2.63560683
30	Abnormality of placental membranes (HP:0011409)	2.61717508
31	Amniotic constriction ring (HP:0009775)	2.61717508
32	Hyperkalemia (HP:0002153)	2.57988481
33	Generalized aminoaciduria (HP:0002909)	2.47574376
34	Increased connective tissue (HP:0009025)	2.46309212
35	Pendular nystagmus (HP:0012043)	2.44587853
36	Abnormal spermatogenesis (HP:0008669)	2.37271119
37	Palpebral edema (HP:0100540)	2.29290884
38	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.21488062
39	Abnormality of nucleobase metabolism (HP:0010932)	2.20086537
40	Absent phalangeal crease (HP:0006109)	2.17790505
41	Mitochondrial inheritance (HP:0001427)	2.16875696
42	Conjunctival hamartoma (HP:0100780)	2.15016876
43	Congenital, generalized hypertrichosis (HP:0004540)	2.11203135
44	Nemaline bodies (HP:0003798)	2.09707394
45	Abnormal rod and cone electroretinograms (HP:0008323)	2.09565340
46	Focal motor seizures (HP:0011153)	2.07859024
47	Hypoplastic pelvis (HP:0008839)	2.03848324
48	Abnormality of T cell physiology (HP:0011840)	2.02245059
49	Myopathic facies (HP:0002058)	2.01724721
50	Increased CSF lactate (HP:0002490)	2.01547640
51	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.00094939
52	Round ear (HP:0100830)	1.99796204
53	IgG deficiency (HP:0004315)	1.98218254
54	Adrenal hypoplasia (HP:0000835)	1.97358437
55	Stenosis of the external auditory canal (HP:0000402)	1.96449397
56	Nausea (HP:0002018)	1.94780998
57	Rough bone trabeculation (HP:0100670)	1.94208845
58	Abnormal finger flexion creases (HP:0006143)	1.93085241
59	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.91998121
60	Mask-like facies (HP:0000298)	1.91835509
61	Asplenia (HP:0001746)	1.87980184
62	Decreased circulating renin level (HP:0003351)	1.82093839
63	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.81967316
64	Hypoplasia of the fovea (HP:0007750)	1.81967316
65	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.80952735
66	Hyperuricemia (HP:0002149)	1.80259553
67	Increased purine levels (HP:0004368)	1.80259553
68	Acute necrotizing encephalopathy (HP:0006965)	1.79505134
69	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.79305572
70	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.75649172
71	Horizontal nystagmus (HP:0000666)	1.74814306
72	Congenital ichthyosiform erythroderma (HP:0007431)	1.74598679
73	Decreased central vision (HP:0007663)	1.73383949
74	Squamous cell carcinoma (HP:0002860)	1.73027972
75	Attenuation of retinal blood vessels (HP:0007843)	1.70921751
76	Hypoalbuminemia (HP:0003073)	1.70847628
77	Abnormal albumin level (HP:0012116)	1.70847628
78	Hypokinesia (HP:0002375)	1.70847166
79	Aplasia/hypoplasia of the uterus (HP:0008684)	1.69119390
80	Increased circulating renin level (HP:0000848)	1.68373461
81	Muscle fiber inclusion bodies (HP:0100299)	1.68325365
82	Myokymia (HP:0002411)	1.67485698
83	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.67310399
84	Hypoplasia of the uterus (HP:0000013)	1.66362789
85	Scotoma (HP:0000575)	1.65600094
86	Distal arthrogryposis (HP:0005684)	1.65593660
87	Bony spicule pigmentary retinopathy (HP:0007737)	1.65385729
88	Aplasia of the musculature (HP:0100854)	1.65345390
89	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	1.63873966
90	Abnormality of male internal genitalia (HP:0000022)	1.63712954
91	Entropion (HP:0000621)	1.63436268
92	Megaloblastic anemia (HP:0001889)	1.63407634
93	Progressive macrocephaly (HP:0004481)	1.60803595
94	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.60170995
95	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.60170995
96	Oral leukoplakia (HP:0002745)	1.60052785
97	Lymphopenia (HP:0001888)	1.57937843
98	Fused cervical vertebrae (HP:0002949)	1.56872423
99	Abolished electroretinogram (ERG) (HP:0000550)	1.54676824
100	Poikiloderma (HP:0001029)	1.54574226

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	5.24316516
2	TESK2	3.55922117
3	CDK19	3.37629062
4	BMPR2	3.36613998
5	TIE1	3.17356643
6	BUB1	3.01979749
7	MAP4K1	2.83416357
8	NEK1	2.50675255
9	TLK1	2.43572961
10	MAP3K12	2.38314790
11	MAP4K2	2.16074290
12	GRK1	2.04261712
13	ADRBK2	2.03785560
14	TAOK3	1.97530185
15	TRIM28	1.94813317
16	PHKG2	1.92271070
17	PHKG1	1.92271070
18	STK39	1.85590298
19	GRK7	1.84360479
20	OXSR1	1.68573522
21	FRK	1.66700411
22	MYLK	1.60571604
23	AURKA	1.58255867
24	OBSCN	1.54703968
25	KDR	1.53343610
26	WNK1	1.50091350
27	TRPM7	1.32372189
28	BMPR1B	1.29732022
29	IKBKB	1.13620336
30	NME2	1.12987946
31	TEC	1.09692582
32	FES	1.09345375
33	CAMK2G	1.08138903
34	CHEK2	1.04977653
35	MKNK2	0.92760045
36	TBK1	0.92149271
37	PLK1	0.91972385
38	CAMK2D	0.83802072
39	ERBB3	0.75604728
40	SCYL2	0.75156770
41	VRK1	0.73800610
42	GSK3A	0.73600607
43	BTK	0.72843932
44	CSNK2A1	0.72522623
45	PNCK	0.71942008
46	TESK1	0.71063201
47	ACVR1B	0.70677753
48	AURKB	0.69466707
49	WNK4	0.65837077
50	TNIK	0.65731746
51	LRRK2	0.65366976
52	NTRK3	0.64693716
53	CAMK2A	0.59607812
54	INSRR	0.59062281
55	CSNK1A1	0.59029899
56	WEE1	0.57145371
57	PRKACA	0.57137758
58	MAPK7	0.56481429
59	DAPK2	0.56098090
60	ILK	0.55740688
61	BRSK1	0.53774620
62	PIM1	0.53283892
63	RPS6KB1	0.52488348
64	GRK5	0.51429748
65	CSNK2A2	0.51203416
66	MKNK1	0.49458525
67	SRPK1	0.49428881
68	CDK9	0.48027356
69	EPHA4	0.47062469
70	PAK4	0.46665003
71	CASK	0.46460204
72	WNK3	0.46258866
73	IGF1R	0.45792565
74	PLK3	0.45671958
75	PRKCG	0.45218132
76	JAK3	0.44685880
77	LIMK1	0.44634235
78	LYN	0.44492428
79	SGK1	0.44377920
80	PRKG1	0.43953785
81	CAMKK2	0.43531813
82	EIF2AK3	0.43332766
83	PRKACB	0.41929662
84	PAK1	0.40728829
85	TGFBR1	0.40567393
86	CSNK1A1L	0.40193360
87	PBK	0.39745534
88	PRKCA	0.39377444
89	ADRBK1	0.39269873
90	PIM2	0.39159688
91	ZAK	0.37824058
92	SYK	0.36455025
93	MAP3K11	0.35443150
94	ABL1	0.34826661
95	MUSK	0.34718230
96	PLK4	0.33248559
97	CSK	0.32882894
98	MAP3K5	0.32648969
99	ABL2	0.31816582
100	ATR	0.29248297

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.74871098
2	Asthma_Homo sapiens_hsa05310	3.65897530
3	Ribosome_Homo sapiens_hsa03010	2.73961072
4	Homologous recombination_Homo sapiens_hsa03440	2.68440648
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.64981936
6	Allograft rejection_Homo sapiens_hsa05330	2.49768795
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.47824727
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.46235455
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.41111181
10	Basal transcription factors_Homo sapiens_hsa03022	2.29144023
11	Parkinsons disease_Homo sapiens_hsa05012	2.21234787
12	Spliceosome_Homo sapiens_hsa03040	2.04775099
13	RNA polymerase_Homo sapiens_hsa03020	2.04267194
14	Graft-versus-host disease_Homo sapiens_hsa05332	2.04095292
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.86339980
16	Alzheimers disease_Homo sapiens_hsa05010	1.76962375
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.64104539
18	Type I diabetes mellitus_Homo sapiens_hsa04940	1.63538934
19	Taste transduction_Homo sapiens_hsa04742	1.60338826
20	Huntingtons disease_Homo sapiens_hsa05016	1.56023222
21	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.55995805
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.52443634
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.49787788
24	Antigen processing and presentation_Homo sapiens_hsa04612	1.49147454
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.48827660
26	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.42275395
27	Protein export_Homo sapiens_hsa03060	1.39715134
28	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.38910887
29	mRNA surveillance pathway_Homo sapiens_hsa03015	1.36110292
30	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.35115542
31	Regulation of autophagy_Homo sapiens_hsa04140	1.31309339
32	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.30695132
33	Phototransduction_Homo sapiens_hsa04744	1.28604472
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.28183631
35	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.22271618
36	Mismatch repair_Homo sapiens_hsa03430	1.18714001
37	RNA transport_Homo sapiens_hsa03013	1.16453365
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.13546551
39	Nicotine addiction_Homo sapiens_hsa05033	1.10541212
40	Olfactory transduction_Homo sapiens_hsa04740	1.08262207
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07468661
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.03588553
43	Caffeine metabolism_Homo sapiens_hsa00232	1.01922631
44	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.99295825
45	RNA degradation_Homo sapiens_hsa03018	0.92572675
46	Oocyte meiosis_Homo sapiens_hsa04114	0.91653760
47	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.88578241
48	Nucleotide excision repair_Homo sapiens_hsa03420	0.88039368
49	Sulfur metabolism_Homo sapiens_hsa00920	0.84981783
50	Purine metabolism_Homo sapiens_hsa00230	0.84901104
51	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.81099344
52	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80581059
53	Morphine addiction_Homo sapiens_hsa05032	0.79952726
54	Primary immunodeficiency_Homo sapiens_hsa05340	0.79260633
55	Rheumatoid arthritis_Homo sapiens_hsa05323	0.77762465
56	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74392595
57	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.74213826
58	Mineral absorption_Homo sapiens_hsa04978	0.74052301
59	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.73722790
60	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.71857336
61	GABAergic synapse_Homo sapiens_hsa04727	0.70100528
62	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.69572328
63	Insulin secretion_Homo sapiens_hsa04911	0.68566715
64	Salivary secretion_Homo sapiens_hsa04970	0.67065069
65	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.66123935
66	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.65130617
67	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.64079223
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60740019
69	DNA replication_Homo sapiens_hsa03030	0.60603301
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57991211
71	Tight junction_Homo sapiens_hsa04530	0.54030640
72	Retinol metabolism_Homo sapiens_hsa00830	0.53214824
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52075269
74	Gastric acid secretion_Homo sapiens_hsa04971	0.51231430
75	Linoleic acid metabolism_Homo sapiens_hsa00591	0.50469066
76	Measles_Homo sapiens_hsa05162	0.49832549
77	Calcium signaling pathway_Homo sapiens_hsa04020	0.48832970
78	Cell cycle_Homo sapiens_hsa04110	0.48677933
79	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.47958955
80	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.46657565
81	Renin-angiotensin system_Homo sapiens_hsa04614	0.43661866
82	Ether lipid metabolism_Homo sapiens_hsa00565	0.43182821
83	Alcoholism_Homo sapiens_hsa05034	0.42600926
84	Viral carcinogenesis_Homo sapiens_hsa05203	0.42123034
85	Circadian entrainment_Homo sapiens_hsa04713	0.41235998
86	Circadian rhythm_Homo sapiens_hsa04710	0.38015436
87	Serotonergic synapse_Homo sapiens_hsa04726	0.37821836
88	Renin secretion_Homo sapiens_hsa04924	0.35998359
89	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.35586503
90	One carbon pool by folate_Homo sapiens_hsa00670	0.35516938
91	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.34996484
92	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.34822006
93	Selenocompound metabolism_Homo sapiens_hsa00450	0.34252759
94	Herpes simplex infection_Homo sapiens_hsa05168	0.34198210
95	Chemical carcinogenesis_Homo sapiens_hsa05204	0.33783497
96	Viral myocarditis_Homo sapiens_hsa05416	0.33055156
97	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.32489461
98	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.31990902
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.31360382
100	Glutamatergic synapse_Homo sapiens_hsa04724	0.31273818

ATP5F1P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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