ATP5G1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* mitochondrial ATP synthesis coupled proton transport (GO:0042776)9.73051083
2* ATP synthesis coupled proton transport (GO:0015986)9.01783161
3* energy coupled proton transport, down electrochemical gradient (GO:0015985)9.01783161
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.44928036
5* respiratory electron transport chain (GO:0022904)7.99019723
6* electron transport chain (GO:0022900)7.77412429
7oxidative phosphorylation (GO:0006119)6.26727295
8tricarboxylic acid cycle (GO:0006099)5.47457443
9establishment of protein localization to mitochondrial membrane (GO:0090151)5.17160785
10* ATP biosynthetic process (GO:0006754)5.05487967
11protein complex biogenesis (GO:0070271)4.99811390
12regulation of mitochondrial translation (GO:0070129)4.96244994
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.83860998
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.83860998
15NADH dehydrogenase complex assembly (GO:0010257)4.83860998
16sarcomere organization (GO:0045214)4.78061518
17mitochondrial respiratory chain complex assembly (GO:0033108)4.70309906
18* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.67176035
19* purine nucleoside triphosphate biosynthetic process (GO:0009145)4.60987684
20NADH metabolic process (GO:0006734)4.58954703
21inner mitochondrial membrane organization (GO:0007007)4.56527075
22* hydrogen ion transmembrane transport (GO:1902600)4.55124669
23chaperone-mediated protein transport (GO:0072321)4.54948233
24proteasome assembly (GO:0043248)4.18332312
25* ribonucleoside triphosphate biosynthetic process (GO:0009201)4.16706563
26positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.13778723
27negative regulation of ligase activity (GO:0051352)4.11757497
28negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.11757497
29cardiac myofibril assembly (GO:0055003)4.10857744
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.07980615
31pseudouridine synthesis (GO:0001522)4.02999493
32quinone biosynthetic process (GO:1901663)4.00119210
33ubiquinone biosynthetic process (GO:0006744)4.00119210
34deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.99244894
35aerobic respiration (GO:0009060)3.98248534
36anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.91299057
37actin-myosin filament sliding (GO:0033275)3.89368959
38muscle filament sliding (GO:0030049)3.89368959
39DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.88657400
40positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.87226528
41regulation of oxidative phosphorylation (GO:0002082)3.85340813
42establishment of integrated proviral latency (GO:0075713)3.82022755
43signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.80962145
44signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.80962145
45signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.80962145
46* proton transport (GO:0015992)3.80502187
47signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.80144170
48intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.80144170
49heart contraction (GO:0060047)3.77804976
50heart process (GO:0003015)3.77804976
51* hydrogen transport (GO:0006818)3.73144170
52myofibril assembly (GO:0030239)3.72823901
53* nucleoside triphosphate biosynthetic process (GO:0009142)3.72647132
54establishment of protein localization to mitochondrion (GO:0072655)3.72015164
55regulation of acyl-CoA biosynthetic process (GO:0050812)3.71955144
56signal transduction involved in DNA integrity checkpoint (GO:0072401)3.71351707
57signal transduction involved in DNA damage checkpoint (GO:0072422)3.71351707
58negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.70616775
59protein targeting to mitochondrion (GO:0006626)3.70588289
60regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.67213613
61cardiac muscle contraction (GO:0060048)3.65377443
62ribosomal small subunit biogenesis (GO:0042274)3.65091280
63signal transduction involved in cell cycle checkpoint (GO:0072395)3.64845113
64viral transcription (GO:0019083)3.62191018
65positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.59409932
66spliceosomal snRNP assembly (GO:0000387)3.58851893
67* purine nucleoside monophosphate biosynthetic process (GO:0009127)3.58814371
68* purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.58814371
69protein neddylation (GO:0045116)3.57999881
70* mitochondrial transport (GO:0006839)3.55970052
71pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.55132708
72translational termination (GO:0006415)3.53813908
73regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.53682028
74regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.53175364
75protein localization to mitochondrion (GO:0070585)3.52567698
76regulation of coenzyme metabolic process (GO:0051196)3.51295678
77regulation of cofactor metabolic process (GO:0051193)3.51295678
78ubiquinone metabolic process (GO:0006743)3.49504840
79regulation of cellular respiration (GO:0043457)3.47322827
80nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46229826
81telomere maintenance via semi-conservative replication (GO:0032201)3.43705443
82respiratory chain complex IV assembly (GO:0008535)3.43414777
83positive regulation of ligase activity (GO:0051351)3.43301549
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.43287449
85cardiac muscle cell development (GO:0055013)3.43162175
86GTP biosynthetic process (GO:0006183)3.36915466
87ribosomal small subunit assembly (GO:0000028)3.34119428
88cytochrome complex assembly (GO:0017004)3.34110509
89translational initiation (GO:0006413)3.32791418
90DNA strand elongation involved in DNA replication (GO:0006271)3.32701229
91DNA deamination (GO:0045006)3.32495970
92regulation of cellular amino acid metabolic process (GO:0006521)3.28560366
93cullin deneddylation (GO:0010388)3.26907981
94regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.26518746
95peptidyl-histidine modification (GO:0018202)3.26098686
96translation (GO:0006412)3.25962445
97negative regulation of potassium ion transmembrane transport (GO:1901380)3.25360554
98rRNA processing (GO:0006364)3.25357981
99cellular respiration (GO:0045333)3.24697730
100succinate metabolic process (GO:0006105)3.24407279
101L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.23658043
102viral life cycle (GO:0019058)3.22097035
103ribosomal large subunit biogenesis (GO:0042273)3.21749276
104regulation of ubiquitin-protein transferase activity (GO:0051438)3.21319042
105translational elongation (GO:0006414)3.21044248
106regulation of relaxation of muscle (GO:1901077)3.19540965
107cellular protein complex disassembly (GO:0043624)3.19033749
108DNA strand elongation (GO:0022616)3.18139115
109termination of RNA polymerase III transcription (GO:0006386)3.17745100
110transcription elongation from RNA polymerase III promoter (GO:0006385)3.17745100
111cardiac muscle tissue morphogenesis (GO:0055008)3.17740967
112maturation of SSU-rRNA (GO:0030490)3.17188813
113oxaloacetate metabolic process (GO:0006107)3.16911562
114establishment of viral latency (GO:0019043)3.16671117
115SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.16224037
116cotranslational protein targeting to membrane (GO:0006613)3.15296659
117ribonucleoprotein complex biogenesis (GO:0022613)3.15009662
118nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14923620
119negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.12703547
120nucleobase-containing small molecule interconversion (GO:0015949)3.11979167
121* generation of precursor metabolites and energy (GO:0006091)3.11705390
122cardiac cell development (GO:0055006)3.11524971
123protein targeting to ER (GO:0045047)3.11356437
124ventricular cardiac muscle cell action potential (GO:0086005)3.10913843
125rRNA metabolic process (GO:0016072)3.10661028
126pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.10341244
127regulation of ligase activity (GO:0051340)3.09399338
128regulation of cellular amine metabolic process (GO:0033238)3.08804863
129actin-mediated cell contraction (GO:0070252)3.08473120
130rRNA modification (GO:0000154)3.07616504
131RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.07220374
132tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.07220374
133ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.05805594
134protein-cofactor linkage (GO:0018065)3.04149422
135protein deneddylation (GO:0000338)3.03025692
136cellular component biogenesis (GO:0044085)3.02991236
137* ribonucleoside monophosphate biosynthetic process (GO:0009156)3.01879992
138guanosine-containing compound biosynthetic process (GO:1901070)3.00901269
139establishment of protein localization to endoplasmic reticulum (GO:0072599)3.00264895
140regulation of actin filament-based movement (GO:1903115)2.99219447
141protein localization to endoplasmic reticulum (GO:0070972)2.97418004
142UTP biosynthetic process (GO:0006228)2.96062678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.05633502
2JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.26555016
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.21862759
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.11804105
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.02722442
6* ETS1_20019798_ChIP-Seq_JURKAT_Human3.94377723
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.91852287
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.71552666
9E2F7_22180533_ChIP-Seq_HELA_Human3.70611271
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.67264352
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.63066701
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.57199175
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.43336112
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.03072866
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03070456
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.78327600
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.71517115
18* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.67228394
19YY1_21170310_ChIP-Seq_MESCs_Mouse2.66615708
20* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.63817447
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.62926263
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.60789264
23* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.56433531
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54678382
25DCP1A_22483619_ChIP-Seq_HELA_Human2.33004340
26* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.32152550
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25922767
28VDR_23849224_ChIP-Seq_CD4+_Human2.20137757
29XRN2_22483619_ChIP-Seq_HELA_Human2.15350244
30* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.98425400
31CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.88905570
32GABP_19822575_ChIP-Seq_HepG2_Human1.85932028
33FOXP3_21729870_ChIP-Seq_TREG_Human1.85673396
34TTF2_22483619_ChIP-Seq_HELA_Human1.83577433
35BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.79578665
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.73998785
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72425453
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56256012
39* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54304102
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54102758
41ELK1_22589737_ChIP-Seq_MCF10A_Human1.47731087
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43990795
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43432033
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43312953
45* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.41209671
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41086396
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39237403
48ELK1_19687146_ChIP-ChIP_HELA_Human1.36461799
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35561788
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35198233
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35052142
52* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34156898
53CTCF_18555785_ChIP-Seq_MESCs_Mouse1.33151401
54EZH2_22144423_ChIP-Seq_EOC_Human1.27302516
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.25257427
56SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24838603
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24599166
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21295025
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19840696
60* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.17430613
61* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.16428606
62* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15426326
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15068701
64YY1_22570637_ChIP-Seq_MALME-3M_Human1.13276593
65ZNF263_19887448_ChIP-Seq_K562_Human1.09271816
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08059033
67CIITA_25753668_ChIP-Seq_RAJI_Human1.08020491
68MYC_18940864_ChIP-ChIP_HL60_Human1.06204292
69MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06190032
70CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04386724
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03315768
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02681516
73FOXM1_23109430_ChIP-Seq_U2OS_Human1.01429204
74OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98586409
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97312609
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96490916
77* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94503963
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93712622
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93041166
80GATA4_21415370_ChIP-Seq_HL-1_Mouse0.92768381
81SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92551789
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92411250
83AR_21909140_ChIP-Seq_LNCAP_Human0.91908465
84SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89983220
85* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88074609
86TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87394880
87VDR_22108803_ChIP-Seq_LS180_Human0.86446348
88* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85377086
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85354556
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83631348
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.82266522
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82111088
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81356999
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81323763
95KDM5A_27292631_Chip-Seq_BREAST_Human0.80731780
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79019866
97* FOXP1_21924763_ChIP-Seq_HESCs_Human0.78661779
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78529769
99ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.77861331
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.76936825
101SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.75575454
102TET1_21451524_ChIP-Seq_MESCs_Mouse0.74291098
103TFEB_21752829_ChIP-Seq_HELA_Human0.73754199
104PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.73512475
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.72969006
106SOX2_18555785_ChIP-Seq_MESCs_Mouse0.72243925
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.69039086
108HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.68965068
109BP1_19119308_ChIP-ChIP_Hs578T_Human0.68766853
110FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68601684
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.66933659
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.66829031
113ERG_20887958_ChIP-Seq_HPC-7_Mouse0.66395419
114CTCF_26484167_Chip-Seq_Bcells_Mouse0.66248617
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.66186970
116RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.65378067

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.49212764
2MP0003646_muscle_fatigue5.45302204
3MP0004084_abnormal_cardiac_muscle4.54555839
4MP0004215_abnormal_myocardial_fiber4.30235278
5MP0000751_myopathy4.27087249
6MP0008058_abnormal_DNA_repair3.65411858
7MP0004036_abnormal_muscle_relaxation3.45258121
8MP0000749_muscle_degeneration3.38440049
9MP0005330_cardiomyopathy3.34508608
10MP0006036_abnormal_mitochondrial_physio3.33642487
11MP0010094_abnormal_chromosome_stability3.20657226
12MP0003137_abnormal_impulse_conducting2.69673716
13MP0006035_abnormal_mitochondrial_morpho2.67459068
14MP0000372_irregular_coat_pigmentation2.54161037
15MP0003111_abnormal_nucleus_morphology2.46946396
16MP0002972_abnormal_cardiac_muscle2.41560867
17MP0000750_abnormal_muscle_regeneration2.40065490
18MP0003806_abnormal_nucleotide_metabolis2.26313083
19MP0001529_abnormal_vocalization2.23587484
20MP0009697_abnormal_copulation2.15620905
21MP0008775_abnormal_heart_ventricle2.10012294
22MP0004087_abnormal_muscle_fiber2.08900989
23MP0005620_abnormal_muscle_contractility2.06247987
24MP0009379_abnormal_foot_pigmentation2.05729749
25MP0004484_altered_response_of2.04527288
26MP0001544_abnormal_cardiovascular_syste2.02376154
27MP0005385_cardiovascular_system_phenoty2.02376154
28MP0008007_abnormal_cellular_replicative2.01582370
29MP0002106_abnormal_muscle_physiology1.99191583
30MP0002269_muscular_atrophy1.97731628
31MP0004145_abnormal_muscle_electrophysio1.93680452
32MP0003221_abnormal_cardiomyocyte_apopto1.81610304
33MP0002332_abnormal_exercise_endurance1.78971228
34MP0003880_abnormal_central_pattern1.74067644
35MP0004085_abnormal_heartbeat1.74052950
36MP0002938_white_spotting1.72989039
37MP0006138_congestive_heart_failure1.72571665
38MP0006292_abnormal_olfactory_placode1.71072436
39MP0000747_muscle_weakness1.66922821
40MP0006276_abnormal_autonomic_nervous1.63181438
41MP0005369_muscle_phenotype1.59193220
42MP0008875_abnormal_xenobiotic_pharmacok1.55335829
43MP0010630_abnormal_cardiac_muscle1.50668953
44MP0005266_abnormal_metabolism1.50274418
45MP0003011_delayed_dark_adaptation1.49376305
46MP0002127_abnormal_cardiovascular_syste1.45839196
47MP0000759_abnormal_skeletal_muscle1.45787034
48MP0004043_abnormal_pH_regulation1.42378049
49MP0003693_abnormal_embryo_hatching1.41528286
50MP0008789_abnormal_olfactory_epithelium1.35017709
51MP0008995_early_reproductive_senescence1.29530814
52MP0004957_abnormal_blastocyst_morpholog1.28619655
53MP0004142_abnormal_muscle_tone1.27273326
54MP0003828_pulmonary_edema1.25448040
55MP0005408_hypopigmentation1.22064247
56MP0003567_abnormal_fetal_cardiomyocyte1.20167017
57MP0002102_abnormal_ear_morphology1.18510847
58MP0001905_abnormal_dopamine_level1.18436838
59MP0003186_abnormal_redox_activity1.17769035
60MP0003718_maternal_effect1.17444672
61MP0002160_abnormal_reproductive_system1.15892825
62MP0004233_abnormal_muscle_weight1.15817649
63MP0004130_abnormal_muscle_cell1.13876983
64MP0005645_abnormal_hypothalamus_physiol1.13378218
65MP0005084_abnormal_gallbladder_morpholo1.12149639
66MP0004147_increased_porphyrin_level1.06046316
67MP0008877_abnormal_DNA_methylation1.02838361
68MP0005075_abnormal_melanosome_morpholog1.01699618
69MP0003941_abnormal_skin_development0.99883597
70MP0002736_abnormal_nociception_after0.99567781
71MP0002822_catalepsy0.98131623
72MP0001727_abnormal_embryo_implantation0.96933714
73MP0001984_abnormal_olfaction0.96740684
74MP0003123_paternal_imprinting0.96388627
75MP0005379_endocrine/exocrine_gland_phen0.95968413
76MP0005386_behavior/neurological_phenoty0.95652668
77MP0004924_abnormal_behavior0.95652668
78MP0003195_calcinosis0.95642002
79MP0003136_yellow_coat_color0.92902457
80MP0000358_abnormal_cell_content/0.90962315
81MP0005646_abnormal_pituitary_gland0.90101911
82MP0002210_abnormal_sex_determination0.90003076
83MP0005451_abnormal_body_composition0.89507593
84MP0005360_urolithiasis0.89348210
85MP0000230_abnormal_systemic_arterial0.87696721
86MP0005332_abnormal_amino_acid0.87621174
87MP0005165_increased_susceptibility_to0.86320789
88MP0001440_abnormal_grooming_behavior0.86052956
89MP0008932_abnormal_embryonic_tissue0.85858663
90MP0002132_abnormal_respiratory_system0.84404349
91MP0000350_abnormal_cell_proliferation0.82980526
92MP0003950_abnormal_plasma_membrane0.80530236
93MP0000313_abnormal_cell_death0.80453187
94MP0001968_abnormal_touch/_nociception0.79682573
95MP0009046_muscle_twitch0.79570685
96MP0005389_reproductive_system_phenotype0.79037678
97MP0001929_abnormal_gametogenesis0.77401541
98MP0002638_abnormal_pupillary_reflex0.77360656
99MP0002735_abnormal_chemical_nociception0.75807086
100MP0005410_abnormal_fertilization0.75503988
101MP0001764_abnormal_homeostasis0.75168196
102MP0002272_abnormal_nervous_system0.73352935
103MP0002095_abnormal_skin_pigmentation0.73311517
104MP0005253_abnormal_eye_physiology0.73125858
105MP0010030_abnormal_orbit_morphology0.73124220
106MP0005376_homeostasis/metabolism_phenot0.72422183
107MP0000653_abnormal_sex_gland0.72287855
108MP0001145_abnormal_male_reproductive0.72245263
109MP0005394_taste/olfaction_phenotype0.71477741
110MP0005499_abnormal_olfactory_system0.71477741
111MP0003315_abnormal_perineum_morphology0.70628862
112MP0005551_abnormal_eye_electrophysiolog0.70329208
113MP0001881_abnormal_mammary_gland0.70016291
114MP0005636_abnormal_mineral_homeostasis0.69132861
115MP0002139_abnormal_hepatobiliary_system0.69121689
116MP0002277_abnormal_respiratory_mucosa0.67501927
117MP0004510_myositis0.66366049
118MP0001730_embryonic_growth_arrest0.66060762
119MP0009745_abnormal_behavioral_response0.65593310
120MP0005395_other_phenotype0.65135221
121MP0002064_seizures0.64318383
122MP0000343_altered_response_to0.63470388
123MP0005083_abnormal_biliary_tract0.63252174
124MP0001293_anophthalmia0.62992435
125MP0008873_increased_physiological_sensi0.62224173
126MP0005085_abnormal_gallbladder_physiolo0.61668890
127MP0005535_abnormal_body_temperature0.60842284
128MP0005319_abnormal_enzyme/_coenzyme0.60211107
129MP0008872_abnormal_physiological_respon0.59448641
130MP0006072_abnormal_retinal_apoptosis0.57213139
131MP0002909_abnormal_adrenal_gland0.56605591
132MP0001485_abnormal_pinna_reflex0.55789828
133MP0003656_abnormal_erythrocyte_physiolo0.54635242
134MP0002067_abnormal_sensory_capabilities0.53221369
135MP0002163_abnormal_gland_morphology0.52594855
136MP0008004_abnormal_stomach_pH0.50938107
137MP0003122_maternal_imprinting0.50359350
138MP0002234_abnormal_pharynx_morphology0.50319379
139MP0001970_abnormal_pain_threshold0.50086357
140MP0000266_abnormal_heart_morphology0.49091378
141MP0003077_abnormal_cell_cycle0.47051859
142MP0003786_premature_aging0.46474340
143MP0005670_abnormal_white_adipose0.45904664
144MP0001756_abnormal_urination0.45629189
145MP0003635_abnormal_synaptic_transmissio0.45441333
146MP0000013_abnormal_adipose_tissue0.45376825
147MP0002876_abnormal_thyroid_physiology0.44895656
148MP0002572_abnormal_emotion/affect_behav0.44827594

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.07215476
2Abnormal mitochondria in muscle tissue (HP:0008316)6.67216689
3Mitochondrial inheritance (HP:0001427)6.20322624
4Acute encephalopathy (HP:0006846)6.03110603
5Progressive macrocephaly (HP:0004481)5.88922116
6Hepatocellular necrosis (HP:0001404)5.67196791
7Increased CSF lactate (HP:0002490)5.55706194
8Hepatic necrosis (HP:0002605)5.45565953
9Sudden death (HP:0001699)4.97955009
10Cerebral edema (HP:0002181)4.66879480
11Increased hepatocellular lipid droplets (HP:0006565)4.42940518
12Lipid accumulation in hepatocytes (HP:0006561)4.26096776
13Lactic acidosis (HP:0003128)4.18780302
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.18259239
15Increased intramyocellular lipid droplets (HP:0012240)4.16646161
16Exercise intolerance (HP:0003546)4.16370016
17Respiratory failure (HP:0002878)4.12792724
18Ventricular tachycardia (HP:0004756)4.01596937
19Calf muscle hypertrophy (HP:0008981)4.00301881
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.00280548
21Decreased activity of mitochondrial respiratory chain (HP:0008972)4.00280548
22Increased muscle lipid content (HP:0009058)3.85089707
23Increased serum lactate (HP:0002151)3.84085997
24Muscle hypertrophy of the lower extremities (HP:0008968)3.80899387
25Abnormality of glycolysis (HP:0004366)3.73794112
26Increased serum pyruvate (HP:0003542)3.73794112
27Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.64380429
28Palpitations (HP:0001962)3.59207859
29Renal Fanconi syndrome (HP:0001994)3.41300245
30Optic disc pallor (HP:0000543)3.38231390
31Atrial fibrillation (HP:0005110)3.24126775
32Exercise-induced myalgia (HP:0003738)3.13226386
33Supraventricular tachycardia (HP:0004755)3.11708703
34Leukodystrophy (HP:0002415)3.07086151
35Primary atrial arrhythmia (HP:0001692)3.06326000
36Exercise-induced muscle cramps (HP:0003710)3.05934707
37Muscle fiber splitting (HP:0003555)3.05064450
38Lipoatrophy (HP:0100578)3.03855688
39Type I transferrin isoform profile (HP:0003642)3.01933631
40Supraventricular arrhythmia (HP:0005115)3.00960172
41Abnormality of the calf musculature (HP:0001430)3.00835820
42Syncope (HP:0001279)2.98277547
43Myoglobinuria (HP:0002913)2.94654132
44Reticulocytopenia (HP:0001896)2.94076174
45CNS demyelination (HP:0007305)2.92246447
46Ventricular fibrillation (HP:0001663)2.89241540
473-Methylglutaconic aciduria (HP:0003535)2.88873530
48Exertional dyspnea (HP:0002875)2.85061432
49Pheochromocytoma (HP:0002666)2.83109618
50Ragged-red muscle fibers (HP:0003200)2.82368378
51Lethargy (HP:0001254)2.80722626
52Neuroendocrine neoplasm (HP:0100634)2.75018969
53Respiratory difficulties (HP:0002880)2.74056595
54Rhabdomyolysis (HP:0003201)2.73696923
55Testicular atrophy (HP:0000029)2.71471975
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.66873264
57Abnormality of alanine metabolism (HP:0010916)2.66873264
58Hyperalaninemia (HP:0003348)2.66873264
59Aplastic anemia (HP:0001915)2.65197533
60Emotional lability (HP:0000712)2.63446949
61Dilated cardiomyopathy (HP:0001644)2.61538067
62Abnormality of cells of the erythroid lineage (HP:0012130)2.61190507
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57972322
64Dicarboxylic aciduria (HP:0003215)2.57972322
65Prolonged QT interval (HP:0001657)2.55855028
66Conjunctival hamartoma (HP:0100780)2.49463418
67Myotonia (HP:0002486)2.49103133
68Abnormal number of erythroid precursors (HP:0012131)2.46279644
69Reduced antithrombin III activity (HP:0001976)2.42697856
70Ventricular arrhythmia (HP:0004308)2.41728976
71Abnormality of urine glucose concentration (HP:0011016)2.41220052
72Glycosuria (HP:0003076)2.41220052
73Progressive external ophthalmoplegia (HP:0000590)2.41045224
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.40953157
75Abnormal protein N-linked glycosylation (HP:0012347)2.40953157
76Abnormal protein glycosylation (HP:0012346)2.40953157
77Abnormal glycosylation (HP:0012345)2.40953157
78Bundle branch block (HP:0011710)2.37416918
79Progressive muscle weakness (HP:0003323)2.33596041
80EMG: myopathic abnormalities (HP:0003458)2.31481009
81Degeneration of anterior horn cells (HP:0002398)2.30023939
82Abnormality of the anterior horn cell (HP:0006802)2.30023939
83Abnormality of the left ventricular outflow tract (HP:0011103)2.29614247
84Subaortic stenosis (HP:0001682)2.29614247
85Ketoacidosis (HP:0001993)2.20546345
86Pancytopenia (HP:0001876)2.18010450
87Amniotic constriction ring (HP:0009775)2.17802429
88Abnormality of placental membranes (HP:0011409)2.17802429
89Oral leukoplakia (HP:0002745)2.16316090
90Right ventricular cardiomyopathy (HP:0011663)2.15619046
91Abnormality of renal resorption (HP:0011038)2.15460333
92Cerebral hypomyelination (HP:0006808)2.15453611
93Abnormal EKG (HP:0003115)2.14741640
94X-linked dominant inheritance (HP:0001423)2.10642749
95Hyperphosphaturia (HP:0003109)2.08238214
96Areflexia of lower limbs (HP:0002522)2.07489861
97Left ventricular hypertrophy (HP:0001712)2.07098712
98Abnormality of aromatic amino acid family metabolism (HP:0004338)2.06287411
99Heart block (HP:0012722)2.05520213
100Vomiting (HP:0002013)2.04859403
101Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04415621
102Gliosis (HP:0002171)2.04327802
103Microvesicular hepatic steatosis (HP:0001414)2.02899661
104Hyporeflexia of lower limbs (HP:0002600)2.00640379
105Hyperglycinemia (HP:0002154)1.97173322
106Nemaline bodies (HP:0003798)1.97041232
107Generalized aminoaciduria (HP:0002909)1.96288004
108Neoplasm of head and neck (HP:0012288)1.95902200
109Esophageal neoplasm (HP:0100751)1.95902200
110Abnormality of fatty-acid metabolism (HP:0004359)1.95900721
111Pallor (HP:0000980)1.95786709
112Myokymia (HP:0002411)1.95606345
113Neoplasm of the adrenal gland (HP:0100631)1.95250611
114Sparse eyelashes (HP:0000653)1.93911715
115Multiple enchondromatosis (HP:0005701)1.93236744
116Colon cancer (HP:0003003)1.92830757
117Methylmalonic acidemia (HP:0002912)1.92592401
118Unsteady gait (HP:0002317)1.92065941
119Macrocytic anemia (HP:0001972)1.91312650
120Abnormal atrioventricular conduction (HP:0005150)1.89686411
121Abnormality of methionine metabolism (HP:0010901)1.89394177
122Atrioventricular block (HP:0001678)1.89276168
123Palmoplantar keratoderma (HP:0000982)1.85786590
124Rough bone trabeculation (HP:0100670)1.85765680
125Muscle stiffness (HP:0003552)1.84243386
126Methylmalonic aciduria (HP:0012120)1.84017400
127Progressive microcephaly (HP:0000253)1.83932064
128Abnormal pupillary function (HP:0007686)1.81615564
129Muscle fiber inclusion bodies (HP:0100299)1.80754423
130Blindness (HP:0000618)1.80094549
131Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.77882156
132Nausea (HP:0002018)1.76341256
133Abnormality of serum amino acid levels (HP:0003112)1.74776089
134Hypoglycemic coma (HP:0001325)1.74005818
135Muscle fiber atrophy (HP:0100295)1.73064942
136Gout (HP:0001997)1.71593975
137Opisthotonus (HP:0002179)1.68536007
138Microretrognathia (HP:0000308)1.67738716
139Metabolic acidosis (HP:0001942)1.67258216
140Hyperglycinuria (HP:0003108)1.66880732
141Cleft eyelid (HP:0000625)1.64156670
142Absent thumb (HP:0009777)1.63885884
143Type 2 muscle fiber atrophy (HP:0003554)1.63358183

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.33570160
2NME13.89358825
3MYLK3.69463261
4NME23.45763532
5OBSCN3.36523575
6BCKDK2.97128435
7STK162.88125111
8BUB12.78541046
9PDK32.59934494
10PDK42.59934494
11CDC72.50646856
12NEK12.48597906
13LMTK22.46606668
14EIF2AK12.44761126
15TTN2.34939825
16PHKG22.22755542
17PHKG12.22755542
18MAP3K122.17526144
19WEE12.04646348
20PINK11.94312176
21TLK11.92109664
22GRK71.91520512
23NUAK11.72838917
24MUSK1.71989617
25ARAF1.60345380
26SRPK11.53674228
27IRAK31.51893734
28ZAK1.51080197
29PDK21.50247886
30WNK41.49830615
31TESK11.41014944
32STK38L1.40407816
33PNCK1.36377629
34STK241.36062845
35BRAF1.35729280
36CAMK2D1.26308519
37PLK41.25177289
38MAP3K111.23500124
39VRK11.22960188
40TAF11.22958202
41PIK3CA1.22152658
42CSNK1G31.21533809
43EIF2AK31.15242841
44TSSK61.14087352
45DAPK31.13387194
46CDK81.06411674
47ILK1.06370708
48PIM21.01065956
49ABL20.99283734
50CDK190.96543812
51GRK50.95229134
52CSNK1G10.94363470
53LIMK10.93598650
54MAP2K70.92070181
55KDR0.90546435
56MARK10.89140849
57MAP4K20.88688260
58CSNK1G20.88176148
59CHEK20.85866819
60ATR0.85855720
61CSNK1A1L0.84227894
62SCYL20.83242681
63CAMK2G0.81733997
64MAPKAPK50.80225941
65MAP3K40.80217789
66CAMK2A0.80110118
67AURKA0.80081662
68STK390.79636723
69BMPR1B0.77755148
70TRIM280.74096929
71MAP3K50.73370441
72MAPKAPK30.72169649
73MAP2K40.70750318
74TTK0.66898177
75AKT30.64881436
76PLK10.64564394
77CDC42BPA0.64377121
78RPS6KA50.63573171
79EIF2AK20.62597555
80CASK0.59612995
81PAK30.59292020
82PAK40.59160616
83TESK20.58617489
84CAMK2B0.58347177
85LATS20.57599898
86PRKACA0.57531835
87TIE10.57304817
88WNK30.56828724
89MINK10.56258000
90GRK10.54216237
91CSNK2A20.52577847
92CSNK2A10.52207206
93ADRBK10.51389124
94PRKCI0.50826946
95LRRK20.49620834
96INSRR0.49459203
97CDK70.49319969
98MAPK120.47215135
99STK40.47206296
100OXSR10.46238141
101BRSK20.45603231
102PAK10.45080534
103DYRK20.44928207
104AURKB0.44881508
105ROCK20.42962112
106PLK30.42808838
107CCNB10.42068176
108PLK20.41909856
109ROCK10.41828383
110PRKCG0.41566365
111ADRBK20.41507871
112PRKCE0.40540803
113CHEK10.37773000
114DAPK10.37616521
115EPHA20.35895833
116DMPK0.35489610
117MAP2K60.35108605
118AKT20.35095427
119RPS6KB20.35009603
120ATM0.33497877
121CSNK1A10.33137727
122PRKACB0.32700570
123PBK0.31983417
124MST40.31973513
125CSNK1E0.28304084
126MKNK10.28239333
127BRSK10.27830106
128RPS6KC10.27809808
129RPS6KL10.27809808
130CAMK10.27350026
131DYRK30.27205050
132PRKD10.26200643
133CDK10.21287405

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.01183039
2Parkinsons disease_Homo sapiens_hsa050125.41382733
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.99408269
4Alzheimers disease_Homo sapiens_hsa050103.88757778
5Huntingtons disease_Homo sapiens_hsa050163.82021279
6Cardiac muscle contraction_Homo sapiens_hsa042603.74542451
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.42737662
8Ribosome_Homo sapiens_hsa030103.37664302
9Proteasome_Homo sapiens_hsa030503.25977260
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.72518940
11RNA polymerase_Homo sapiens_hsa030202.32862499
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.89655866
13Carbon metabolism_Homo sapiens_hsa012001.84358184
14Propanoate metabolism_Homo sapiens_hsa006401.78419556
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67939088
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.67309093
17Pyruvate metabolism_Homo sapiens_hsa006201.63780560
18Pyrimidine metabolism_Homo sapiens_hsa002401.44355414
19Protein export_Homo sapiens_hsa030601.37895100
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34698607
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29547346
22Non-homologous end-joining_Homo sapiens_hsa034501.19593417
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14960781
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11797929
25DNA replication_Homo sapiens_hsa030301.10407432
26Dilated cardiomyopathy_Homo sapiens_hsa054141.10231202
27Biosynthesis of amino acids_Homo sapiens_hsa012301.09089804
28Collecting duct acid secretion_Homo sapiens_hsa049661.08834394
29Fatty acid degradation_Homo sapiens_hsa000711.06558894
30Butanoate metabolism_Homo sapiens_hsa006501.05933433
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.02477907
32Fatty acid elongation_Homo sapiens_hsa000621.01445604
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99338829
34Mismatch repair_Homo sapiens_hsa034300.97627410
35* Metabolic pathways_Homo sapiens_hsa011000.90271224
36Purine metabolism_Homo sapiens_hsa002300.87332026
37Spliceosome_Homo sapiens_hsa030400.84213013
38Phenylalanine metabolism_Homo sapiens_hsa003600.80275363
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79467498
40Homologous recombination_Homo sapiens_hsa034400.79188558
41Nucleotide excision repair_Homo sapiens_hsa034200.75709955
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74342322
43Arginine and proline metabolism_Homo sapiens_hsa003300.74152340
44Sulfur metabolism_Homo sapiens_hsa009200.72955776
45RNA transport_Homo sapiens_hsa030130.71547831
46Fructose and mannose metabolism_Homo sapiens_hsa000510.71458368
47Sulfur relay system_Homo sapiens_hsa041220.69274559
48Fatty acid metabolism_Homo sapiens_hsa012120.67914627
49Glutathione metabolism_Homo sapiens_hsa004800.65833623
50Folate biosynthesis_Homo sapiens_hsa007900.65338662
51Cell cycle_Homo sapiens_hsa041100.63659708
52Vibrio cholerae infection_Homo sapiens_hsa051100.62346918
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59384997
54Selenocompound metabolism_Homo sapiens_hsa004500.59106254
55Pentose phosphate pathway_Homo sapiens_hsa000300.56576989
56Peroxisome_Homo sapiens_hsa041460.56419176
57Tyrosine metabolism_Homo sapiens_hsa003500.55160029
58beta-Alanine metabolism_Homo sapiens_hsa004100.54410742
59Nitrogen metabolism_Homo sapiens_hsa009100.52651392
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51507545
61Galactose metabolism_Homo sapiens_hsa000520.51030267
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49184235
63N-Glycan biosynthesis_Homo sapiens_hsa005100.46485075
64RNA degradation_Homo sapiens_hsa030180.45777268
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45393228
66Chemical carcinogenesis_Homo sapiens_hsa052040.43958103
67Regulation of autophagy_Homo sapiens_hsa041400.41585314
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41302044
69Base excision repair_Homo sapiens_hsa034100.40552536
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39758198
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39748821
72Tryptophan metabolism_Homo sapiens_hsa003800.39160462
73Steroid biosynthesis_Homo sapiens_hsa001000.37972498
74Synaptic vesicle cycle_Homo sapiens_hsa047210.37063580
75One carbon pool by folate_Homo sapiens_hsa006700.36704589
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.35675321
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.35330705
78Basal transcription factors_Homo sapiens_hsa030220.34940122
79Nicotine addiction_Homo sapiens_hsa050330.32981188
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.32508737
81Vitamin B6 metabolism_Homo sapiens_hsa007500.31500540
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29655172
83Arachidonic acid metabolism_Homo sapiens_hsa005900.28455113
84Starch and sucrose metabolism_Homo sapiens_hsa005000.28198214
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.27079554
86Arginine biosynthesis_Homo sapiens_hsa002200.25252602
87Fat digestion and absorption_Homo sapiens_hsa049750.24821103
88Calcium signaling pathway_Homo sapiens_hsa040200.24403256
89Phototransduction_Homo sapiens_hsa047440.23487045
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23428780
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23374222
92Retinol metabolism_Homo sapiens_hsa008300.21581378
93Vitamin digestion and absorption_Homo sapiens_hsa049770.21433624
94Fanconi anemia pathway_Homo sapiens_hsa034600.20661702
95Taste transduction_Homo sapiens_hsa047420.19148023
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17920805
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.17429926
98Linoleic acid metabolism_Homo sapiens_hsa005910.17192730
99mRNA surveillance pathway_Homo sapiens_hsa030150.16913385
100Systemic lupus erythematosus_Homo sapiens_hsa053220.16871054
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16820108
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.16770023
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15913413
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.15463124
105Glucagon signaling pathway_Homo sapiens_hsa049220.14533195
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.14333578
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.13236157
108Caffeine metabolism_Homo sapiens_hsa002320.12763643
109Mineral absorption_Homo sapiens_hsa049780.12634771
110Oocyte meiosis_Homo sapiens_hsa041140.11590695
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.10274326
112Epstein-Barr virus infection_Homo sapiens_hsa051690.10174917
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.09930208
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06555661
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.05918276
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.04018392
117Insulin secretion_Homo sapiens_hsa049110.03049325
118HIF-1 signaling pathway_Homo sapiens_hsa040660.02982745
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.02036355
120GABAergic synapse_Homo sapiens_hsa047270.01776630
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.01122486
122Viral myocarditis_Homo sapiens_hsa054160.00478321

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