ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	6.62022948
2	regulation of mitotic spindle organization (GO:0060236)	5.75973621
3	mitotic sister chromatid segregation (GO:0000070)	5.31849790
4	regulation of spindle organization (GO:0090224)	5.24892483
5	kinetochore organization (GO:0051383)	5.18119277
6	kinetochore assembly (GO:0051382)	5.12263375
7	mitotic metaphase plate congression (GO:0007080)	4.95518871
8	sister chromatid segregation (GO:0000819)	4.88044602
9	spindle assembly involved in mitosis (GO:0090307)	4.83411723
10	meiotic chromosome segregation (GO:0045132)	4.78134488
11	metaphase plate congression (GO:0051310)	4.75675738
12	protein localization to chromosome, centromeric region (GO:0071459)	4.72535535
13	establishment of chromosome localization (GO:0051303)	4.68942427
14	base-excision repair, AP site formation (GO:0006285)	4.56777491
15	microtubule depolymerization (GO:0007019)	4.53257865
16	protein localization to kinetochore (GO:0034501)	4.52803245
17	CENP-A containing nucleosome assembly (GO:0034080)	4.24232443
18	establishment of integrated proviral latency (GO:0075713)	4.23399364
19	DNA ligation (GO:0006266)	4.19515363
20	chromatin remodeling at centromere (GO:0031055)	4.09120883
21	mitotic chromosome condensation (GO:0007076)	3.97728032
22	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.96263540
23	establishment of viral latency (GO:0019043)	3.89628448
24	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.83335819
25	microtubule cytoskeleton organization involved in mitosis (GO:1902850)	3.75755709
26	ventricular cardiac muscle cell development (GO:0055015)	3.73358356
27	cullin deneddylation (GO:0010388)	3.72498435
28	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.67860396
29	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.67104158
30	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.66073075
31	DNA topological change (GO:0006265)	3.65958970
32	DNA strand renaturation (GO:0000733)	3.62599991
33	regulation of DNA endoreduplication (GO:0032875)	3.60191743
34	chromosome segregation (GO:0007059)	3.59045203
35	proteasome assembly (GO:0043248)	3.58498537
36	protein deneddylation (GO:0000338)	3.55309497
37	protein localization to chromosome (GO:0034502)	3.47329905
38	pyrimidine nucleotide catabolic process (GO:0006244)	3.41782929
39	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.39955297
40	negative regulation of ligase activity (GO:0051352)	3.39955297
41	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.39864538
42	spindle checkpoint (GO:0031577)	3.39725253
43	regulation of chromosome segregation (GO:0051983)	3.39645179
44	regulation of centrosome cycle (GO:0046605)	3.33929538
45	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.21400589
46	protein K6-linked ubiquitination (GO:0085020)	3.20475874
47	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.20389767
48	amino acid salvage (GO:0043102)	3.20329777
49	L-methionine salvage (GO:0071267)	3.20329777
50	L-methionine biosynthetic process (GO:0071265)	3.20329777
51	rRNA modification (GO:0000154)	3.16527981
52	chaperone-mediated protein transport (GO:0072321)	3.15821215
53	mitotic nuclear envelope disassembly (GO:0007077)	3.15354799
54	chromosome condensation (GO:0030261)	3.11787919
55	histone exchange (GO:0043486)	3.11736940
56	pseudouridine synthesis (GO:0001522)	3.10021350
57	positive regulation of ligase activity (GO:0051351)	3.09301018
58	mitotic spindle checkpoint (GO:0071174)	3.06407277
59	DNA replication-independent nucleosome organization (GO:0034724)	3.04752542
60	DNA replication-independent nucleosome assembly (GO:0006336)	3.04752542
61	DNA strand elongation involved in DNA replication (GO:0006271)	3.04439617
62	DNA strand elongation (GO:0022616)	2.99441092
63	ribosomal large subunit biogenesis (GO:0042273)	2.97228398
64	telomere maintenance via semi-conservative replication (GO:0032201)	2.96935694
65	regulation of mitochondrial translation (GO:0070129)	2.92819238
66	ATP synthesis coupled proton transport (GO:0015986)	2.92440170
67	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.92440170
68	deoxyribonucleotide catabolic process (GO:0009264)	2.92063965
69	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.91782606
70	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.91782606
71	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.91782606
72	mitotic spindle organization (GO:0007052)	2.91026027
73	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.90489026
74	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.88212599
75	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.88212599
76	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.87897465
77	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.87597660
78	negative regulation of chromosome segregation (GO:0051985)	2.86570272
79	DNA unwinding involved in DNA replication (GO:0006268)	2.86137123
80	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.84780807
81	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.83688944
82	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.83688944
83	regulation of ligase activity (GO:0051340)	2.82455639
84	membrane disassembly (GO:0030397)	2.82184765
85	nuclear envelope disassembly (GO:0051081)	2.82184765
86	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.80706412
87	negative regulation of sister chromatid segregation (GO:0033046)	2.80706412
88	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.80706412
89	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.80706412
90	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.80706412
91	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.80681804
92	mitotic spindle assembly checkpoint (GO:0007094)	2.79626554
93	C-terminal protein lipidation (GO:0006501)	2.79483670
94	protein K11-linked ubiquitination (GO:0070979)	2.79399867
95	spindle assembly checkpoint (GO:0071173)	2.79376506
96	regulation of cellular amino acid metabolic process (GO:0006521)	2.78952930
97	replication fork processing (GO:0031297)	2.76567983
98	respiratory chain complex IV assembly (GO:0008535)	2.76298816
99	muscle cell fate commitment (GO:0042693)	2.76040956
100	mitotic cell cycle (GO:0000278)	2.75835057

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXM1_23109430_ChIP-Seq_U2OS_Human	7.51641649
2	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	5.10288341
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.40006903
4	E2F7_22180533_ChIP-Seq_HELA_Human	3.96444687
5	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.62122415
6	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.48730774
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.42880441
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.26967144
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.13345634
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.90952066
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.84502063
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.83095771
13	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.81462074
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.70723739
15	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.70016248
16	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.66986999
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.60087660
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.57866747
19	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.48776807
20	XRN2_22483619_ChIP-Seq_HELA_Human	2.48104659
21	DCP1A_22483619_ChIP-Seq_HELA_Human	2.39426974
22	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.35104879
23	AR_21909140_ChIP-Seq_LNCAP_Human	2.30104166
24	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.18058489
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.08388129
26	GABP_19822575_ChIP-Seq_HepG2_Human	2.05684285
27	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.02864404
28	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.98446691
29	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.98411065
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.98305654
31	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.95027654
32	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.94844388
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.90428648
34	VDR_23849224_ChIP-Seq_CD4+_Human	1.85316531
35	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.79290857
36	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.78016436
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.77547107
38	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.73997980
39	TTF2_22483619_ChIP-Seq_HELA_Human	1.70957412
40	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.68709619
41	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.65265923
42	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.63984297
43	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.63608860
44	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.62894334
45	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.62862371
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.61771898
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.61234333
48	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.56977499
49	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.53163486
50	KDM5A_27292631_Chip-Seq_BREAST_Human	1.52281706
51	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.51711305
52	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.48855143
53	ZNF263_19887448_ChIP-Seq_K562_Human	1.37105722
54	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.34253888
55	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.33471468
56	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.32542393
57	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.25933371
58	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.18551500
59	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.18036207
60	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.16150104
61	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.15161089
62	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.14436610
63	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.13434036
64	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.11437077
65	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.08033718
66	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.07820729
67	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.07727832
68	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.07628721
69	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.05494263
70	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.03052401
71	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.02435660
72	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.96319349
73	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.95951878
74	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.94566644
75	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.91456010
76	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.90881047
77	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.90777068
78	ELF5_23300383_ChIP-Seq_T47D_Human	0.90133562
79	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.89931876
80	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.89577408
81	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.88670140
82	MYC_18940864_ChIP-ChIP_HL60_Human	0.88280840
83	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.88201579
84	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.87772272
85	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.87543945
86	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	0.86497644
87	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.85283000
88	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.84937755
89	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.84546900
90	ATF3_27146783_Chip-Seq_COLON_Human	0.83976300
91	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.83185077
92	TFEB_21752829_ChIP-Seq_HELA_Human	0.82704609
93	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.82303184
94	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.80805463
95	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.79387554
96	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.78690295
97	CIITA_25753668_ChIP-Seq_RAJI_Human	0.78284318
98	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.76209284
99	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.75329721
100	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.74319233

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	4.45602394
2	MP0003111_abnormal_nucleus_morphology	4.00181541
3	MP0010094_abnormal_chromosome_stability	3.65751023
4	MP0003950_abnormal_plasma_membrane	3.62138980
5	MP0004957_abnormal_blastocyst_morpholog	3.43616381
6	MP0010030_abnormal_orbit_morphology	3.36703109
7	MP0002234_abnormal_pharynx_morphology	3.31932027
8	MP0003077_abnormal_cell_cycle	3.05606041
9	MP0008789_abnormal_olfactory_epithelium	2.97026992
10	MP0008058_abnormal_DNA_repair	2.84343458
11	MP0008932_abnormal_embryonic_tissue	2.63187530
12	MP0003718_maternal_effect	2.50658003
13	MP0006292_abnormal_olfactory_placode	2.46825759
14	MP0003786_premature_aging	2.30405922
15	MP0001986_abnormal_taste_sensitivity	2.29703632
16	MP0003705_abnormal_hypodermis_morpholog	2.08585732
17	MP0008007_abnormal_cellular_replicative	1.98428572
18	MP0000750_abnormal_muscle_regeneration	1.97863945
19	MP0008877_abnormal_DNA_methylation	1.94335662
20	MP0005394_taste/olfaction_phenotype	1.93571658
21	MP0005499_abnormal_olfactory_system	1.93571658
22	MP0009053_abnormal_anal_canal	1.89417772
23	MP0005257_abnormal_intraocular_pressure	1.86518709
24	MP0004147_increased_porphyrin_level	1.84413305
25	MP0003806_abnormal_nucleotide_metabolis	1.82102217
26	MP0005360_urolithiasis	1.70792676
27	MP0005174_abnormal_tail_pigmentation	1.63393117
28	MP0000358_abnormal_cell_content/	1.53040683
29	MP0005501_abnormal_skin_physiology	1.49613298
30	MP0005083_abnormal_biliary_tract	1.46783992
31	MP0001661_extended_life_span	1.38963879
32	MP0002210_abnormal_sex_determination	1.38301713
33	MP0009780_abnormal_chondrocyte_physiolo	1.33282096
34	MP0003123_paternal_imprinting	1.32146280
35	MP0003191_abnormal_cellular_cholesterol	1.29488709
36	MP0006036_abnormal_mitochondrial_physio	1.28168390
37	MP0001929_abnormal_gametogenesis	1.27721416
38	MP0005084_abnormal_gallbladder_morpholo	1.26344814
39	MP0005330_cardiomyopathy	1.21226938
40	MP0005451_abnormal_body_composition	1.18032023
41	MP0001697_abnormal_embryo_size	1.17979283
42	MP0008995_early_reproductive_senescence	1.17846118
43	MP0001881_abnormal_mammary_gland	1.17819407
44	MP0001529_abnormal_vocalization	1.15183915
45	MP0001764_abnormal_homeostasis	1.09310743
46	MP0002080_prenatal_lethality	1.06167249
47	MP0001542_abnormal_bone_strength	1.04718268
48	MP0005395_other_phenotype	1.04680013
49	MP0006072_abnormal_retinal_apoptosis	1.02732604
50	MP0001299_abnormal_eye_distance/	1.01859351
51	MP0001145_abnormal_male_reproductive	1.01125112
52	MP0002233_abnormal_nose_morphology	0.99489593
53	MP0005380_embryogenesis_phenotype	0.99018232
54	MP0001672_abnormal_embryogenesis/_devel	0.99018232
55	MP0001919_abnormal_reproductive_system	0.97977258
56	MP0005408_hypopigmentation	0.97711731
57	MP0008260_abnormal_autophagy	0.97470342
58	MP0008875_abnormal_xenobiotic_pharmacok	0.96739175
59	MP0002019_abnormal_tumor_incidence	0.96539609
60	MP0005171_absent_coat_pigmentation	0.94308218
61	MP0000653_abnormal_sex_gland	0.92555483
62	MP0003195_calcinosis	0.91822682
63	MP0006054_spinal_hemorrhage	0.89173690
64	MP0000350_abnormal_cell_proliferation	0.89122454
65	MP0000647_abnormal_sebaceous_gland	0.88604339
66	MP0001730_embryonic_growth_arrest	0.88307601
67	MP0000313_abnormal_cell_death	0.87985491
68	MP0000015_abnormal_ear_pigmentation	0.87837897
69	MP0010307_abnormal_tumor_latency	0.86472520
70	MP0001293_anophthalmia	0.86249995
71	MP0002085_abnormal_embryonic_tissue	0.84947683
72	MP0003699_abnormal_female_reproductive	0.84028597
73	MP0001119_abnormal_female_reproductive	0.83692574
74	MP0006035_abnormal_mitochondrial_morpho	0.82737752
75	MP0003315_abnormal_perineum_morphology	0.82270903
76	MP0008775_abnormal_heart_ventricle	0.82228338
77	MP0002160_abnormal_reproductive_system	0.81907628
78	MP0010368_abnormal_lymphatic_system	0.81314610
79	MP0001853_heart_inflammation	0.79724358
80	MP0000427_abnormal_hair_cycle	0.79637822
81	MP0003984_embryonic_growth_retardation	0.78799269
82	MP0009250_abnormal_appendicular_skeleto	0.78718681
83	MP0005389_reproductive_system_phenotype	0.77404595
84	MP0003959_abnormal_lean_body	0.77282741
85	MP0003186_abnormal_redox_activity	0.76974115
86	MP0003755_abnormal_palate_morphology	0.76889030
87	MP0002088_abnormal_embryonic_growth/wei	0.75865517
88	MP0002060_abnormal_skin_morphology	0.74608740
89	MP0000490_abnormal_crypts_of	0.72085211
90	MP0005647_abnormal_sex_gland	0.72012590
91	MP0003136_yellow_coat_color	0.70819312
92	MP0002938_white_spotting	0.69808605
93	MP0000627_abnormal_mammary_gland	0.69660578
94	MP0005165_increased_susceptibility_to	0.69393347
95	MP0000537_abnormal_urethra_morphology	0.69094106
96	MP0003937_abnormal_limbs/digits/tail_de	0.68578511
97	MP0002177_abnormal_outer_ear	0.68209359
98	MP0000733_abnormal_muscle_development	0.66364872
99	MP0005197_abnormal_uvea_morphology	0.64824585
100	MP0004197_abnormal_fetal_growth/weight/	0.64726665

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Popliteal pterygium (HP:0009756)	5.38037064
2	Abnormality of placental membranes (HP:0011409)	5.26640314
3	Amniotic constriction ring (HP:0009775)	5.26640314
4	Aplasia of the musculature (HP:0100854)	4.10740309
5	Type 2 muscle fiber atrophy (HP:0003554)	3.86229824
6	Testicular atrophy (HP:0000029)	3.83457438
7	Aplasia/Hypoplasia involving the musculature (HP:0001460)	3.45209729
8	Fetal akinesia sequence (HP:0001989)	3.44823266
9	Muscle fiber atrophy (HP:0100295)	3.43342780
10	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.30525515
11	Chromsome breakage (HP:0040012)	3.21927599
12	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.19791807
13	Facial hemangioma (HP:0000329)	3.17292874
14	Squamous cell carcinoma (HP:0002860)	3.14117434
15	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.08648753
16	Poikiloderma (HP:0001029)	3.06536517
17	Increased hepatocellular lipid droplets (HP:0006565)	3.04853749
18	Renal Fanconi syndrome (HP:0001994)	3.01330556
19	Acute necrotizing encephalopathy (HP:0006965)	2.96157608
20	Hepatocellular necrosis (HP:0001404)	2.89028309
21	Mitochondrial inheritance (HP:0001427)	2.84853975
22	Acute encephalopathy (HP:0006846)	2.78937009
23	Meckel diverticulum (HP:0002245)	2.68930567
24	Abnormal mitochondria in muscle tissue (HP:0008316)	2.66375210
25	Akinesia (HP:0002304)	2.64579823
26	Hepatic necrosis (HP:0002605)	2.63976808
27	Increased CSF lactate (HP:0002490)	2.63766999
28	Abnormality of the preputium (HP:0100587)	2.62391551
29	Abnormalities of placenta or umbilical cord (HP:0001194)	2.54677091
30	Rectovaginal fistula (HP:0000143)	2.52212115
31	Rectal fistula (HP:0100590)	2.52212115
32	Microglossia (HP:0000171)	2.50878978
33	Abnormality of midbrain morphology (HP:0002418)	2.50470627
34	Molar tooth sign on MRI (HP:0002419)	2.50470627
35	Abnormality of chromosome stability (HP:0003220)	2.50096639
36	Secondary amenorrhea (HP:0000869)	2.48800223
37	Lipid accumulation in hepatocytes (HP:0006561)	2.45086827
38	Abnormality of the ileum (HP:0001549)	2.44662662
39	Microretrognathia (HP:0000308)	2.43649676
40	Breast hypoplasia (HP:0003187)	2.37683412
41	Fatigable weakness (HP:0003473)	2.35712418
42	Abnormality of the neuromuscular junction (HP:0003398)	2.35712418
43	Absent thumb (HP:0009777)	2.35485270
44	Abnormality of the intrinsic pathway (HP:0010989)	2.35163914
45	Glucose intolerance (HP:0000833)	2.34777599
46	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.34473173
47	Adrenal hypoplasia (HP:0000835)	2.32404359
48	Tubulointerstitial nephritis (HP:0001970)	2.32147540
49	Pterygium (HP:0001059)	2.30172640
50	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.25166468
51	Progressive macrocephaly (HP:0004481)	2.22827300
52	Broad distal phalanx of finger (HP:0009836)	2.22477789
53	Microvesicular hepatic steatosis (HP:0001414)	2.22297652
54	Dyschromatopsia (HP:0007641)	2.20211023
55	Exercise intolerance (HP:0003546)	2.18977726
56	Increased serum lactate (HP:0002151)	2.16728623
57	Sloping forehead (HP:0000340)	2.14827267
58	Short nail (HP:0001799)	2.14400566
59	Entropion (HP:0000621)	2.14016935
60	Vaginal fistula (HP:0004320)	2.13343179
61	Progressive muscle weakness (HP:0003323)	2.10838918
62	Reticulocytopenia (HP:0001896)	2.08824198
63	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.08552979
64	Rough bone trabeculation (HP:0100670)	2.07678645
65	Respiratory difficulties (HP:0002880)	2.04834461
66	Chorioretinal atrophy (HP:0000533)	2.02608777
67	Aplasia/Hypoplasia of the patella (HP:0006498)	1.99205992
68	Abnormality of cells of the erythroid lineage (HP:0012130)	1.95738434
69	Intestinal fistula (HP:0100819)	1.95192629
70	Hypoplasia of the uterus (HP:0000013)	1.94908920
71	Abnormal number of erythroid precursors (HP:0012131)	1.94904963
72	Patellar aplasia (HP:0006443)	1.92754349
73	Premature ovarian failure (HP:0008209)	1.92629655
74	Lactic acidosis (HP:0003128)	1.91084057
75	Cerebral hypomyelination (HP:0006808)	1.90463919
76	Myelodysplasia (HP:0002863)	1.90186415
77	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.89051951
78	Cerebral edema (HP:0002181)	1.88446170
79	Short thumb (HP:0009778)	1.86904651
80	Small intestinal stenosis (HP:0012848)	1.86565931
81	Duodenal stenosis (HP:0100867)	1.86565931
82	Hypoplastic heart (HP:0001961)	1.85900548
83	Absent septum pellucidum (HP:0001331)	1.83820517
84	Abnormality of glycolysis (HP:0004366)	1.82567235
85	Weak cry (HP:0001612)	1.81703175
86	Abnormal trabecular bone morphology (HP:0100671)	1.81436696
87	Rib fusion (HP:0000902)	1.81128643
88	Cystic hygroma (HP:0000476)	1.80163213
89	Reduced subcutaneous adipose tissue (HP:0003758)	1.79829480
90	Aplasia/hypoplasia of the humerus (HP:0006507)	1.78597347
91	Malignant hyperthermia (HP:0002047)	1.76541439
92	Increased serum pyruvate (HP:0003542)	1.74253683
93	Small hand (HP:0200055)	1.73796925
94	Horseshoe kidney (HP:0000085)	1.73771949
95	Tubular atrophy (HP:0000092)	1.73172866
96	Abnormality of methionine metabolism (HP:0010901)	1.72882040
97	Anencephaly (HP:0002323)	1.71500618
98	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.71429006
99	Easy fatigability (HP:0003388)	1.70142399
100	Sparse eyelashes (HP:0000653)	1.70110856

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BUB1	6.18821911
2	NEK2	3.54396305
3	PBK	3.41304253
4	TTK	3.08809240
5	BRSK1	2.81164875
6	VRK2	2.79101326
7	ZAK	2.54982727
8	WEE1	2.49777775
9	NEK1	2.30405047
10	BRSK2	2.22622486
11	BCKDK	2.22229120
12	TESK2	2.22202043
13	PLK3	2.16754728
14	PLK1	2.12890456
15	NME2	2.08520637
16	SRPK1	2.03725850
17	MAPKAPK3	2.03047222
18	PDK2	1.95462500
19	LIMK1	1.89861650
20	CCNB1	1.86101586
21	MST1R	1.71171449
22	CDC7	1.68498888
23	AURKA	1.64788260
24	STK10	1.64589935
25	EPHA2	1.60010534
26	ERBB4	1.59170390
27	MUSK	1.53671129
28	TESK1	1.41416120
29	TRIM28	1.40556562
30	CHEK2	1.40098708
31	AURKB	1.40023760
32	MAPK15	1.27090327
33	EIF2AK1	1.23076205
34	BRAF	1.20632853
35	STK16	1.20213418
36	TSSK6	1.16576922
37	PLK4	1.16187752
38	MELK	1.08629850
39	SIK3	1.08560060
40	VRK1	1.08145306
41	MAP3K8	1.06588554
42	ATR	1.02319375
43	MAP3K10	1.00417751
44	DAPK1	0.99650164
45	SCYL2	0.97086084
46	EIF2AK2	0.96776616
47	DYRK3	0.95891907
48	CSNK1G3	0.94430002
49	CDK7	0.93843125
50	PRKCI	0.89954715
51	PAK4	0.89632809
52	MST4	0.89439120
53	STK3	0.85121354
54	TLK1	0.79614123
55	PAK1	0.75687521
56	WNK4	0.75611035
57	MAP3K12	0.71458901
58	MET	0.68307772
59	CDK18	0.67987542
60	CSNK1A1L	0.66696627
61	CSNK1G1	0.66243026
62	ABL2	0.64962081
63	GRK1	0.63750505
64	CDK15	0.63033447
65	CSNK1G2	0.62255185
66	CHEK1	0.62206979
67	NME1	0.62061041
68	CDK11A	0.61657685
69	BCR	0.61052158
70	CDK8	0.60514906
71	MAPK11	0.56694602
72	CDK14	0.56506482
73	TAF1	0.56330711
74	PTK2	0.54779159
75	MOS	0.53025232
76	CSNK2A1	0.51758482
77	MKNK2	0.46856832
78	CSNK2A2	0.45664480
79	AKT2	0.44614040
80	RPS6KB2	0.43783721
81	CDK1	0.41810177
82	SIK1	0.41245970
83	MKNK1	0.41058154
84	EPHB2	0.40596524
85	EIF2AK3	0.40461286
86	ATM	0.40253822
87	LMTK2	0.38170461
88	PLK2	0.37991176
89	LATS2	0.37674323
90	IRAK3	0.37461233
91	CDK4	0.35086689
92	MARK3	0.35050913
93	STK4	0.34469377
94	STK39	0.33221955
95	CLK1	0.29835801
96	FLT3	0.29501993
97	PAK2	0.27804182
98	BMPR1B	0.27253698
99	MYLK	0.26629916
100	ILK	0.26451265

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.96252949
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.26945863
3	Mismatch repair_Homo sapiens_hsa03430	3.00149483
4	DNA replication_Homo sapiens_hsa03030	2.97261230
5	Homologous recombination_Homo sapiens_hsa03440	2.96899638
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.81639922
7	Base excision repair_Homo sapiens_hsa03410	2.62950143
8	RNA polymerase_Homo sapiens_hsa03020	2.62380767
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.60911407
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.56734168
11	Sulfur relay system_Homo sapiens_hsa04122	2.55722912
12	Non-homologous end-joining_Homo sapiens_hsa03450	2.45408256
13	Cell cycle_Homo sapiens_hsa04110	2.41347726
14	Ribosome_Homo sapiens_hsa03010	2.39879977
15	Oxidative phosphorylation_Homo sapiens_hsa00190	2.33831982
16	Nucleotide excision repair_Homo sapiens_hsa03420	2.13697836
17	Pyrimidine metabolism_Homo sapiens_hsa00240	2.12880585
18	RNA transport_Homo sapiens_hsa03013	2.03694517
19	p53 signaling pathway_Homo sapiens_hsa04115	2.00376709
20	Basal transcription factors_Homo sapiens_hsa03022	1.92431503
21	Parkinsons disease_Homo sapiens_hsa05012	1.91020503
22	Protein export_Homo sapiens_hsa03060	1.83925795
23	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.83753494
24	Huntingtons disease_Homo sapiens_hsa05016	1.75730632
25	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.61012946
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.50769147
27	RNA degradation_Homo sapiens_hsa03018	1.45291597
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.44325501
29	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.42258793
30	Fatty acid elongation_Homo sapiens_hsa00062	1.39902811
31	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.37268081
32	Spliceosome_Homo sapiens_hsa03040	1.33177707
33	Glutathione metabolism_Homo sapiens_hsa00480	1.29896045
34	Alzheimers disease_Homo sapiens_hsa05010	1.25828442
35	Folate biosynthesis_Homo sapiens_hsa00790	1.22782551
36	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.22320820
37	Pyruvate metabolism_Homo sapiens_hsa00620	1.20083768
38	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.16705017
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.09328689
40	Purine metabolism_Homo sapiens_hsa00230	1.08430248
41	One carbon pool by folate_Homo sapiens_hsa00670	1.08228934
42	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.04312666
43	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.03083230
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.00906855
45	Oocyte meiosis_Homo sapiens_hsa04114	0.98893788
46	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.98661299
47	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.97281440
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.95276674
49	Carbon metabolism_Homo sapiens_hsa01200	0.94621430
50	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.89450160
51	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.85920113
52	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.84392459
53	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.81198449
54	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.80436806
55	Sulfur metabolism_Homo sapiens_hsa00920	0.75338304
56	Metabolic pathways_Homo sapiens_hsa01100	0.73070732
57	Propanoate metabolism_Homo sapiens_hsa00640	0.71938140
58	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.69163581
59	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.68765836
60	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.68283294
61	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.65996895
62	mRNA surveillance pathway_Homo sapiens_hsa03015	0.60856466
63	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.59863871
64	Sphingolipid metabolism_Homo sapiens_hsa00600	0.58150254
65	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.57938340
66	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.56316700
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.55245003
68	Cardiac muscle contraction_Homo sapiens_hsa04260	0.54547480
69	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.52249509
70	Pentose phosphate pathway_Homo sapiens_hsa00030	0.45795783
71	Hippo signaling pathway_Homo sapiens_hsa04390	0.43743311
72	Regulation of autophagy_Homo sapiens_hsa04140	0.43319831
73	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.42463459
74	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.41927562
75	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.39649262
76	Steroid biosynthesis_Homo sapiens_hsa00100	0.38497891
77	Tyrosine metabolism_Homo sapiens_hsa00350	0.36401774
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.36251353
79	Peroxisome_Homo sapiens_hsa04146	0.35775247
80	Galactose metabolism_Homo sapiens_hsa00052	0.35457965
81	Shigellosis_Homo sapiens_hsa05131	0.32410127
82	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.31715102
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.30368501
84	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.27733126
85	Nitrogen metabolism_Homo sapiens_hsa00910	0.27095032
86	Vibrio cholerae infection_Homo sapiens_hsa05110	0.26904410
87	Arginine and proline metabolism_Homo sapiens_hsa00330	0.26373365
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.26232294
89	Phototransduction_Homo sapiens_hsa04744	0.23732514
90	Bladder cancer_Homo sapiens_hsa05219	0.20750206
91	Basal cell carcinoma_Homo sapiens_hsa05217	0.20078314
92	Viral carcinogenesis_Homo sapiens_hsa05203	0.19317498
93	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.19070159
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.17109716
95	Apoptosis_Homo sapiens_hsa04210	0.14260161
96	Lysosome_Homo sapiens_hsa04142	0.13081642
97	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.12165850
98	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.07518683
99	Small cell lung cancer_Homo sapiens_hsa05222	0.06506499
100	HTLV-I infection_Homo sapiens_hsa05166	0.06430579

ATP5G1P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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