ATP5G1P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.09346610
2cytidine metabolic process (GO:0046087)7.08879214
3cytidine catabolic process (GO:0006216)7.08879214
4cytidine deamination (GO:0009972)7.08879214
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.24863948
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.95898497
7ubiquinone biosynthetic process (GO:0006744)5.20707558
8protein neddylation (GO:0045116)5.03125935
9proteasome assembly (GO:0043248)5.01266745
10positive regulation of tolerance induction (GO:0002645)4.79737956
11regulation of chronic inflammatory response (GO:0002676)4.78920733
12ubiquinone metabolic process (GO:0006743)4.67957274
13positive T cell selection (GO:0043368)4.57025122
14regulation of T cell tolerance induction (GO:0002664)4.40336427
15regulation of transmission of nerve impulse (GO:0051969)4.40136861
16quinone biosynthetic process (GO:1901663)4.26453040
17negative regulation by host of viral transcription (GO:0043922)4.08017159
18rRNA modification (GO:0000154)3.99194711
19ATP synthesis coupled proton transport (GO:0015986)3.87936010
20energy coupled proton transport, down electrochemical gradient (GO:0015985)3.87936010
21positive thymic T cell selection (GO:0045059)3.79509492
22ovulation cycle (GO:0042698)3.72337877
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.71311390
24Arp2/3 complex-mediated actin nucleation (GO:0034314)3.68254258
25regulation of tolerance induction (GO:0002643)3.67193719
26regulation of female gonad development (GO:2000194)3.59728944
27DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.54813027
28arginine catabolic process (GO:0006527)3.51435562
29negative T cell selection (GO:0043383)3.49405306
30regulation of bile acid biosynthetic process (GO:0070857)3.47188485
31negative regulation of telomere maintenance (GO:0032205)3.45576682
32intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.43475322
33signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.43475322
34regulation of cellular amino acid metabolic process (GO:0006521)3.42757889
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.41512965
36respiratory chain complex IV assembly (GO:0008535)3.41068695
37signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.40832405
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.40832405
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.40832405
40meiotic chromosome segregation (GO:0045132)3.38816219
41actin nucleation (GO:0045010)3.36798955
42maturation of 5.8S rRNA (GO:0000460)3.36736752
43positive regulation of fatty acid beta-oxidation (GO:0032000)3.35447448
44response to pheromone (GO:0019236)3.33585844
45negative regulation of protein tyrosine kinase activity (GO:0061099)3.31807184
46negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.30767330
47rRNA methylation (GO:0031167)3.29854751
48regulation of lymphocyte chemotaxis (GO:1901623)3.29337886
49mismatch repair (GO:0006298)3.28968782
50regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.25833553
51negative regulation of ligase activity (GO:0051352)3.25109962
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.25109962
53tyrosine phosphorylation of STAT protein (GO:0007260)3.24590616
54arginine metabolic process (GO:0006525)3.22110704
55signal transduction involved in DNA integrity checkpoint (GO:0072401)3.19096113
56signal transduction involved in DNA damage checkpoint (GO:0072422)3.19096113
57signal transduction involved in cell cycle checkpoint (GO:0072395)3.14127292
58pseudouridine synthesis (GO:0001522)3.11761441
59positive regulation of humoral immune response (GO:0002922)3.10935953
60base-excision repair, AP site formation (GO:0006285)3.07467161
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.06831667
62respiratory electron transport chain (GO:0022904)3.01857933
63electron transport chain (GO:0022900)3.01757686
64glycerol metabolic process (GO:0006071)3.00222395
65negative regulation of viral genome replication (GO:0045071)3.00092202
66pyrimidine nucleoside catabolic process (GO:0046135)2.98352206
67positive regulation of fatty acid oxidation (GO:0046321)2.98164840
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.97364905
69RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.97364905
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.96583652
71alkaloid metabolic process (GO:0009820)2.94105745
72positive regulation of calcium-mediated signaling (GO:0050850)2.92196531
73positive regulation of cell cycle arrest (GO:0071158)2.90239332
74regulation of cellular amine metabolic process (GO:0033238)2.88701506
75mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.88500072
76positive regulation of prostaglandin secretion (GO:0032308)2.88382363
77modulation by host of symbiont transcription (GO:0052472)2.84384345
78modulation by host of viral transcription (GO:0043921)2.84384345
79regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.84334936
80thymic T cell selection (GO:0045061)2.82065166
81alditol metabolic process (GO:0019400)2.81028940
82modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.80358057
83positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.79077381
84cytochrome complex assembly (GO:0017004)2.78270411
85regulation of alpha-beta T cell proliferation (GO:0046640)2.76729884
86antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.75314157
87T cell selection (GO:0045058)2.71851707
88negative regulation of neurological system process (GO:0031645)2.70074796
89regulation of viral genome replication (GO:0045069)2.69089652
90response to interferon-beta (GO:0035456)2.69023457
91behavioral response to nicotine (GO:0035095)2.68039883
92protein complex biogenesis (GO:0070271)2.67935092
93DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.67770044
94cytokine biosynthetic process (GO:0042089)2.64544905
95anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.64403376
96positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.63850271
97positive regulation of T cell mediated cytotoxicity (GO:0001916)2.63518147
98cellular response to interferon-beta (GO:0035458)2.62377173
99negative thymic T cell selection (GO:0045060)2.60175471
100response to xenobiotic stimulus (GO:0009410)2.59200629

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.45887443
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.69772235
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.20746985
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.10541836
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.10147360
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.05866109
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.95014292
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.69532070
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59257698
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.53147622
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47412520
12VDR_22108803_ChIP-Seq_LS180_Human2.44666914
13IGF1R_20145208_ChIP-Seq_DFB_Human2.43507771
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39385114
15VDR_23849224_ChIP-Seq_CD4+_Human2.26692393
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.15359609
17CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86736925
18IRF8_21731497_ChIP-ChIP_J774_Mouse1.73182160
19FOXP3_21729870_ChIP-Seq_TREG_Human1.71796096
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.70266153
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68984537
22STAT1_20625510_ChIP-Seq_HELA_Human1.65728601
23SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63933171
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.63316542
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.60412061
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.57179213
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.56321960
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56312969
29ZNF274_21170338_ChIP-Seq_K562_Hela1.53064276
30TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.46380098
31NCOR_22424771_ChIP-Seq_293T_Human1.46194250
32EGR1_23403033_ChIP-Seq_LIVER_Mouse1.45241759
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44208168
34PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.42770264
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40839707
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39796788
37MYC_18940864_ChIP-ChIP_HL60_Human1.37873705
38HOXB7_26014856_ChIP-Seq_BT474_Human1.36825917
39IRF1_19129219_ChIP-ChIP_H3396_Human1.35911208
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35154260
41ELK1_19687146_ChIP-ChIP_HELA_Human1.34740674
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33634263
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33498937
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31621778
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30135262
46TP53_22573176_ChIP-Seq_HFKS_Human1.28902390
47NANOG_19829295_ChIP-Seq_ESCs_Human1.27599299
48SOX2_19829295_ChIP-Seq_ESCs_Human1.27599299
49EWS_26573619_Chip-Seq_HEK293_Human1.26835764
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.26552815
51PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.25774638
52FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25521802
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25213836
54GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.23243834
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22881380
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22841985
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21575934
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21453345
59GATA3_26560356_Chip-Seq_TH1_Human1.20994940
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18615940
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.18615940
62FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18478573
63GATA3_26560356_Chip-Seq_TH2_Human1.17547670
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17026069
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.16404776
66FOXH1_21741376_ChIP-Seq_EPCs_Human1.16115902
67MYB_26560356_Chip-Seq_TH2_Human1.15752842
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14288959
69ER_23166858_ChIP-Seq_MCF-7_Human1.13565370
70MYC_19829295_ChIP-Seq_ESCs_Human1.12670245
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12018818
72P300_19829295_ChIP-Seq_ESCs_Human1.11669338
73AR_20517297_ChIP-Seq_VCAP_Human1.11502337
74RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10454481
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08446122
76NANOG_20526341_ChIP-Seq_ESCs_Human1.08253856
77ERA_21632823_ChIP-Seq_H3396_Human1.07931507
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.05390610
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99191664
80HTT_18923047_ChIP-ChIP_STHdh_Human0.98108026
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97634956
82GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96065897
83EZH2_22144423_ChIP-Seq_EOC_Human0.95838258
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95427821
85TAF2_19829295_ChIP-Seq_ESCs_Human0.94599218
86ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94146721
87PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93991971
88FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93841547
89PRDM14_20953172_ChIP-Seq_ESCs_Human0.93794826
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93021886
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92832947
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92604134
93POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91828810
94CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91700628
95TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.91184360
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89246918
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88659010
98CBP_20019798_ChIP-Seq_JUKART_Human0.88659010
99OCT4_20526341_ChIP-Seq_ESCs_Human0.88317355
100GATA6_21074721_ChIP-Seq_CACO-2_Human0.88126628

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system5.81617283
2MP0005646_abnormal_pituitary_gland3.41901651
3MP0005360_urolithiasis2.59351468
4MP0001835_abnormal_antigen_presentation2.56998121
5MP0009333_abnormal_splenocyte_physiolog2.44577605
6MP0001968_abnormal_touch/_nociception2.37305380
7MP0001873_stomach_inflammation2.31533161
8MP0002837_dystrophic_cardiac_calcinosis2.28554335
9MP0000685_abnormal_immune_system2.27790481
10MP0005671_abnormal_response_to2.24996068
11MP0005084_abnormal_gallbladder_morpholo2.11050583
12MP0005187_abnormal_penis_morphology2.03316853
13MP0009764_decreased_sensitivity_to2.03114297
14MP0009785_altered_susceptibility_to2.01879793
15MP0003195_calcinosis2.01074355
16MP0009697_abnormal_copulation2.00961109
17MP0005645_abnormal_hypothalamus_physiol1.98313998
18MP0001188_hyperpigmentation1.97607398
19MP0006082_CNS_inflammation1.95630755
20MP0005083_abnormal_biliary_tract1.94388249
21MP0008875_abnormal_xenobiotic_pharmacok1.90962754
22MP0008007_abnormal_cellular_replicative1.79141607
23MP0005085_abnormal_gallbladder_physiolo1.78960878
24MP0005167_abnormal_blood-brain_barrier1.78433238
25MP0001790_abnormal_immune_system1.76200264
26MP0005387_immune_system_phenotype1.76200264
27MP0002166_altered_tumor_susceptibility1.73384381
28MP0001984_abnormal_olfaction1.73161856
29MP0003186_abnormal_redox_activity1.72335018
30MP0003315_abnormal_perineum_morphology1.68099831
31MP0000613_abnormal_salivary_gland1.64150978
32MP0004145_abnormal_muscle_electrophysio1.58720886
33MP0002148_abnormal_hypersensitivity_rea1.58405027
34MP0001986_abnormal_taste_sensitivity1.56777393
35MP0002736_abnormal_nociception_after1.54334462
36MP0003763_abnormal_thymus_physiology1.51566388
37MP0008872_abnormal_physiological_respon1.49260788
38MP0003646_muscle_fatigue1.47493315
39MP0003123_paternal_imprinting1.47157247
40MP0001501_abnormal_sleep_pattern1.46393860
41MP0003806_abnormal_nucleotide_metabolis1.43153005
42MP0003252_abnormal_bile_duct1.42454489
43MP0001800_abnormal_humoral_immune1.42141206
44MP0001348_abnormal_lacrimal_gland1.38501519
45MP0002876_abnormal_thyroid_physiology1.29965775
46MP0005000_abnormal_immune_tolerance1.29303941
47MP0004043_abnormal_pH_regulation1.26327519
48MP0001727_abnormal_embryo_implantation1.23741070
49MP0002006_tumorigenesis1.19175453
50MP0003075_altered_response_to1.17543355
51MP0008877_abnormal_DNA_methylation1.16131345
52MP0003567_abnormal_fetal_cardiomyocyte1.15806139
53MP0002638_abnormal_pupillary_reflex1.13620983
54MP0006054_spinal_hemorrhage1.13100906
55MP0002420_abnormal_adaptive_immunity1.11961384
56MP0002723_abnormal_immune_serum1.09798471
57MP0005165_increased_susceptibility_to1.07649755
58MP0002272_abnormal_nervous_system1.07484656
59MP0005389_reproductive_system_phenotype1.07312948
60MP0001819_abnormal_immune_cell1.06972330
61MP0001905_abnormal_dopamine_level1.06086364
62MP0002139_abnormal_hepatobiliary_system1.05478479
63MP0010386_abnormal_urinary_bladder0.97564374
64MP0005025_abnormal_response_to0.95715552
65MP0001919_abnormal_reproductive_system0.94056623
66MP0009745_abnormal_behavioral_response0.93780604
67MP0000716_abnormal_immune_system0.93640182
68MP0002452_abnormal_antigen_presenting0.91556747
69MP0002733_abnormal_thermal_nociception0.90523147
70MP0010155_abnormal_intestine_physiology0.90288138
71MP0001845_abnormal_inflammatory_respons0.87802743
72MP0003786_premature_aging0.86620585
73MP0002160_abnormal_reproductive_system0.85813576
74MP0005365_abnormal_bile_salt0.84777819
75MP0005636_abnormal_mineral_homeostasis0.83112872
76MP0003718_maternal_effect0.83036237
77MP0006276_abnormal_autonomic_nervous0.82373227
78MP0000689_abnormal_spleen_morphology0.81670844
79MP0002405_respiratory_system_inflammati0.80964960
80MP0008873_increased_physiological_sensi0.80925412
81MP0006072_abnormal_retinal_apoptosis0.80526807
82MP0003693_abnormal_embryo_hatching0.80086395
83MP0004084_abnormal_cardiac_muscle0.79922989
84MP0000703_abnormal_thymus_morphology0.78854562
85MP0009046_muscle_twitch0.78415414
86MP0004782_abnormal_surfactant_physiolog0.78025425
87MP0002398_abnormal_bone_marrow0.77881948
88MP0005367_renal/urinary_system_phenotyp0.77210236
89MP0000516_abnormal_urinary_system0.77210236
90MP0002277_abnormal_respiratory_mucosa0.76836576
91MP0005253_abnormal_eye_physiology0.75531332
92MP0003638_abnormal_response/metabolism_0.75119189
93MP0001243_abnormal_dermal_layer0.73283383
94MP0008469_abnormal_protein_level0.72987435
95MP0000467_abnormal_esophagus_morphology0.72148655
96MP0003868_abnormal_feces_composition0.71769738
97MP0005535_abnormal_body_temperature0.70890375
98MP0004019_abnormal_vitamin_homeostasis0.70381330
99MP0002102_abnormal_ear_morphology0.70013762
100MP0002722_abnormal_immune_system0.68228526

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)6.56597526
2Acute necrotizing encephalopathy (HP:0006965)4.28127890
3Autoimmune hemolytic anemia (HP:0001890)4.05065866
4Increased IgM level (HP:0003496)4.04842967
5Acute encephalopathy (HP:0006846)3.93083951
6Abnormal mitochondria in muscle tissue (HP:0008316)3.92212137
7Congenital stationary night blindness (HP:0007642)3.89633250
8Mitochondrial inheritance (HP:0001427)3.81350530
9Increased CSF lactate (HP:0002490)3.73947319
10Progressive macrocephaly (HP:0004481)3.73913457
11Prostate neoplasm (HP:0100787)3.69846389
12Large eyes (HP:0001090)3.45224501
13Abnormality of the prostate (HP:0008775)3.42037191
14Hepatocellular necrosis (HP:0001404)3.36470704
15Decreased central vision (HP:0007663)3.16139573
16Eosinophilia (HP:0001880)3.09018652
17Congenital, generalized hypertrichosis (HP:0004540)3.05593820
18Cerebral edema (HP:0002181)3.01686713
19Fair hair (HP:0002286)2.96245169
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.92865484
21Abnormality of alanine metabolism (HP:0010916)2.92865484
22Hyperalaninemia (HP:0003348)2.92865484
23Renal cortical cysts (HP:0000803)2.84993863
24Hepatic necrosis (HP:0002605)2.80480915
25Submucous cleft hard palate (HP:0000176)2.79918241
26Pancytopenia (HP:0001876)2.75003504
27Optic disc pallor (HP:0000543)2.72166494
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.71176422
29Pancreatic cysts (HP:0001737)2.70145278
30Abnormality of eosinophils (HP:0001879)2.62444296
31Chronic sinusitis (HP:0011109)2.62303025
32Increased hepatocellular lipid droplets (HP:0006565)2.60549721
33Abnormal rod and cone electroretinograms (HP:0008323)2.59753132
34Severe combined immunodeficiency (HP:0004430)2.50411353
35Renal Fanconi syndrome (HP:0001994)2.45989145
36Abnormality of the renal cortex (HP:0011035)2.44010757
37Recurrent bronchitis (HP:0002837)2.43963349
38Aplastic anemia (HP:0001915)2.43160356
39Gastrointestinal infarctions (HP:0005244)2.42823090
40Generalized hypopigmentation of hair (HP:0011358)2.36933368
41Alveolar cell carcinoma (HP:0006519)2.36458876
42Dry hair (HP:0011359)2.36405020
43Hypokinesia (HP:0002375)2.34591254
44Lipid accumulation in hepatocytes (HP:0006561)2.34364612
45Stomatitis (HP:0010280)2.34013026
46Ridged nail (HP:0001807)2.33980850
47Granulocytopenia (HP:0001913)2.27186226
48Respiratory failure (HP:0002878)2.22652960
49Ulnar claw (HP:0001178)2.22021209
50Hypoproteinemia (HP:0003075)2.21638159
51Lactic acidosis (HP:0003128)2.20904422
52Microretrognathia (HP:0000308)2.18565947
53Abnormality of the vocal cords (HP:0008777)2.17878674
54True hermaphroditism (HP:0010459)2.15820324
55IgG deficiency (HP:0004315)2.15275671
56Hypergammaglobulinemia (HP:0010702)2.13467261
57Oral leukoplakia (HP:0002745)2.12576954
58Abnormality of T cell number (HP:0011839)2.06143735
59Lethargy (HP:0001254)2.05594255
60Abnormality of the axillary hair (HP:0100134)2.03778001
61Abnormality of secondary sexual hair (HP:0009888)2.03778001
62Increased serum lactate (HP:0002151)2.02828672
63Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01679583
64Autoimmune thrombocytopenia (HP:0001973)2.00977304
65Parakeratosis (HP:0001036)1.99388832
66Leukocytosis (HP:0001974)1.97864218
67Reduced subcutaneous adipose tissue (HP:0003758)1.95024144
68Gangrene (HP:0100758)1.94424132
69Recurrent gram-negative bacterial infections (HP:0005420)1.94403303
70Clubbing of toes (HP:0100760)1.94094674
71Pigmentary retinal degeneration (HP:0001146)1.93956192
72Abnormality of the renal medulla (HP:0100957)1.93142419
73Erythema (HP:0010783)1.91249123
74Thyroiditis (HP:0100646)1.87801720
75Vasculitis (HP:0002633)1.87738087
76Abnormal biliary tract physiology (HP:0012439)1.85896610
77Bile duct proliferation (HP:0001408)1.85896610
78Respiratory difficulties (HP:0002880)1.85419610
79Nephronophthisis (HP:0000090)1.85096434
80Keratoconus (HP:0000563)1.83978762
81Increased corneal curvature (HP:0100692)1.83978762
82Congenital hepatic fibrosis (HP:0002612)1.83320766
83Neoplasm of the tracheobronchial system (HP:0100552)1.82243055
84Combined immunodeficiency (HP:0005387)1.80945542
85Abnormality of male internal genitalia (HP:0000022)1.80047243
86Abnormality of B cell number (HP:0010975)1.79662374
87Conjugated hyperbilirubinemia (HP:0002908)1.77877482
88Leukodystrophy (HP:0002415)1.77395428
89Sclerocornea (HP:0000647)1.76554954
90Attenuation of retinal blood vessels (HP:0007843)1.76221721
91Delayed CNS myelination (HP:0002188)1.76135262
92Pancreatic fibrosis (HP:0100732)1.73136020
93Bilateral microphthalmos (HP:0007633)1.72769916
94Agammaglobulinemia (HP:0004432)1.71655369
95Pulmonary infiltrates (HP:0002113)1.69854337
96Scanning speech (HP:0002168)1.68960554
97Abnormality of serum amino acid levels (HP:0003112)1.68864584
98Mesangial abnormality (HP:0001966)1.66462584
99Bronchitis (HP:0012387)1.65167168
100Increased intramyocellular lipid droplets (HP:0012240)1.65009892

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.21856399
2SRPK13.37720440
3BUB13.33423124
4MAP4K13.07047750
5VRK22.92846908
6TXK2.68782309
7WNK42.60081181
8PIK3CA2.44912016
9ADRBK22.36470400
10PDK22.31861618
11AKT32.30531959
12BCKDK2.25285251
13VRK12.18380425
14EIF2AK32.07890756
15NUAK11.69435175
16NEK11.67388625
17PHKG21.63405927
18PHKG11.63405927
19GRK11.62439976
20PLK21.58460129
21PRKCQ1.55902509
22FRK1.55245296
23CLK11.51464278
24TLK11.41248035
25ITK1.34968735
26IKBKB1.34815760
27STK41.22563507
28WNK31.18140303
29TESK21.13929764
30TIE11.06987970
31PLK31.05240396
32EIF2AK11.04713745
33LYN1.04539003
34SYK1.00728884
35PIM21.00526204
36INSRR0.99665198
37CSF1R0.98581739
38MAP3K110.97189595
39TRIM280.94167197
40PRKCH0.93714363
41TAF10.93442936
42MAPKAPK30.92406627
43PRKCG0.91581667
44PTK60.89434579
45ZAK0.86329168
46MAP3K120.86035324
47LCK0.81670817
48PTK2B0.80829532
49DAPK10.78284756
50AURKA0.74387550
51BRAF0.74372802
52OXSR10.72745426
53EIF2AK20.72463984
54TSSK60.71557372
55PRKCE0.71280807
56PAK20.70714029
57CAMKK20.69026742
58IKBKE0.67469519
59NME10.67110638
60MYLK0.66080919
61CSNK1G30.63617676
62TBK10.63536547
63MAPKAPK50.62015227
64FES0.60853807
65ZAP700.60367933
66GRK50.59731095
67PRKCI0.58901313
68CSNK1G10.58469517
69LIMK10.58278522
70PRKACA0.56654321
71CSNK1A1L0.56364388
72EPHB20.55938800
73PRKCA0.54587430
74DYRK20.52968456
75STK390.52656004
76PRKCZ0.52377656
77PINK10.51708751
78CSNK1G20.49941224
79MAPK130.49937979
80MAP2K70.49101010
81CSNK2A20.48917315
82PLK10.48205087
83BMPR1B0.48153030
84CSNK1A10.45270467
85CSK0.44653292
86MINK10.44317390
87KIT0.43616454
88CSNK1D0.42955493
89CDC70.42415763
90TNIK0.41433189
91OBSCN0.41219818
92TTK0.40811827
93IGF1R0.39277059
94MUSK0.38773043
95PRKACG0.38722921
96PRKG10.38175032
97MARK30.37346846
98PRKCD0.37068844
99INSR0.35786982
100CSNK2A10.34524953

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.94916869
2Proteasome_Homo sapiens_hsa030504.93121742
3Asthma_Homo sapiens_hsa053103.06075507
4Primary immunodeficiency_Homo sapiens_hsa053403.04366029
5Graft-versus-host disease_Homo sapiens_hsa053322.93064074
6Allograft rejection_Homo sapiens_hsa053302.88244844
7Type I diabetes mellitus_Homo sapiens_hsa049402.84452543
8Autoimmune thyroid disease_Homo sapiens_hsa053202.79868739
9Oxidative phosphorylation_Homo sapiens_hsa001902.73948614
10Parkinsons disease_Homo sapiens_hsa050122.40457553
11Antigen processing and presentation_Homo sapiens_hsa046122.02413818
12Hematopoietic cell lineage_Homo sapiens_hsa046401.83245989
13Protein export_Homo sapiens_hsa030601.78455969
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65796698
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62204923
16Alzheimers disease_Homo sapiens_hsa050101.58308017
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.56690760
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.56405348
19Nitrogen metabolism_Homo sapiens_hsa009101.44464835
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43087136
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42404191
22Linoleic acid metabolism_Homo sapiens_hsa005911.42214946
23Huntingtons disease_Homo sapiens_hsa050161.40663758
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40598981
25Propanoate metabolism_Homo sapiens_hsa006401.37921491
26Peroxisome_Homo sapiens_hsa041461.32125606
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.28754796
28Rheumatoid arthritis_Homo sapiens_hsa053231.20325463
29Caffeine metabolism_Homo sapiens_hsa002321.18803606
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12838759
31Arginine biosynthesis_Homo sapiens_hsa002201.09464286
32Butanoate metabolism_Homo sapiens_hsa006501.07164166
33RNA degradation_Homo sapiens_hsa030181.06793766
34Cardiac muscle contraction_Homo sapiens_hsa042601.06319595
35Tryptophan metabolism_Homo sapiens_hsa003801.05657344
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00149070
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98944453
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97220252
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97147931
40Nucleotide excision repair_Homo sapiens_hsa034200.96925127
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94074995
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90980734
43beta-Alanine metabolism_Homo sapiens_hsa004100.89105551
44Ribosome_Homo sapiens_hsa030100.88054672
45Viral myocarditis_Homo sapiens_hsa054160.87477108
46RNA polymerase_Homo sapiens_hsa030200.84656104
47T cell receptor signaling pathway_Homo sapiens_hsa046600.84128925
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81920005
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80242073
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80108880
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77747380
52Staphylococcus aureus infection_Homo sapiens_hsa051500.77201008
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.75947533
54Chemical carcinogenesis_Homo sapiens_hsa052040.75832843
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73970041
56Phototransduction_Homo sapiens_hsa047440.68538082
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67585939
58Pyrimidine metabolism_Homo sapiens_hsa002400.66950317
59Salmonella infection_Homo sapiens_hsa051320.66325293
60Retinol metabolism_Homo sapiens_hsa008300.65436771
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64882554
62Basal transcription factors_Homo sapiens_hsa030220.64867554
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64633342
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.63014701
65Measles_Homo sapiens_hsa051620.62592339
66Sulfur metabolism_Homo sapiens_hsa009200.62562429
67Fatty acid degradation_Homo sapiens_hsa000710.62377996
68Carbon metabolism_Homo sapiens_hsa012000.59308164
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57730161
70Steroid biosynthesis_Homo sapiens_hsa001000.57304459
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57258289
72Complement and coagulation cascades_Homo sapiens_hsa046100.56966539
73Tyrosine metabolism_Homo sapiens_hsa003500.55472255
74Systemic lupus erythematosus_Homo sapiens_hsa053220.51335250
75Sulfur relay system_Homo sapiens_hsa041220.50337090
76Fanconi anemia pathway_Homo sapiens_hsa034600.49521918
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47717983
78RNA transport_Homo sapiens_hsa030130.47536402
79Homologous recombination_Homo sapiens_hsa034400.47358302
80One carbon pool by folate_Homo sapiens_hsa006700.46607553
81Base excision repair_Homo sapiens_hsa034100.46003537
82Metabolic pathways_Homo sapiens_hsa011000.45011506
83Purine metabolism_Homo sapiens_hsa002300.44911800
84Fatty acid elongation_Homo sapiens_hsa000620.44821049
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43284448
86Biosynthesis of amino acids_Homo sapiens_hsa012300.43075529
87Collecting duct acid secretion_Homo sapiens_hsa049660.43062020
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.42591138
89ABC transporters_Homo sapiens_hsa020100.40541619
90Pyruvate metabolism_Homo sapiens_hsa006200.37673378
91Fat digestion and absorption_Homo sapiens_hsa049750.34842494
92Mismatch repair_Homo sapiens_hsa034300.32872640
93Ether lipid metabolism_Homo sapiens_hsa005650.32710199
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28590217
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27482789
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27463223
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.23795024
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23187792
99Mineral absorption_Homo sapiens_hsa049780.23098129
100Serotonergic synapse_Homo sapiens_hsa047260.22771208

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