ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ketone body metabolic process (GO:1902224)	9.04924109
2	ribosomal small subunit assembly (GO:0000028)	6.57083173
3	DNA deamination (GO:0045006)	5.98916093
4	acrosome reaction (GO:0007340)	5.93450730
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.37518899
6	regulation of G0 to G1 transition (GO:0070316)	5.19117912
7	peptidyl-threonine dephosphorylation (GO:0035970)	4.98204002
8	kynurenine metabolic process (GO:0070189)	4.92050687
9	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.90817533
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.71023596
11	ATP synthesis coupled proton transport (GO:0015986)	4.71023596
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.67474671
13	respiratory electron transport chain (GO:0022904)	4.63261121
14	electron transport chain (GO:0022900)	4.60937871
15	sleep (GO:0030431)	4.28495509
16	omega-hydroxylase P450 pathway (GO:0097267)	4.27028146
17	glycine transport (GO:0015816)	4.16937686
18	indole-containing compound catabolic process (GO:0042436)	4.06784969
19	indolalkylamine catabolic process (GO:0046218)	4.06784969
20	tryptophan catabolic process (GO:0006569)	4.06784969
21	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	3.95916128
22	behavioral response to nicotine (GO:0035095)	3.83630831
23	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.78627269
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.78595474
25	cytidine deamination (GO:0009972)	3.56963083
26	cytidine metabolic process (GO:0046087)	3.56963083
27	cytidine catabolic process (GO:0006216)	3.56963083
28	vitamin A metabolic process (GO:0006776)	3.56423180
29	negative regulation of mast cell activation (GO:0033004)	3.50898745
30	actin nucleation (GO:0045010)	3.41080783
31	negative regulation of telomere maintenance (GO:0032205)	3.36895709
32	DNA strand renaturation (GO:0000733)	3.35462602
33	positive regulation of histone H3-K4 methylation (GO:0051571)	3.30048890
34	lateral sprouting from an epithelium (GO:0060601)	3.28201746
35	tryptophan metabolic process (GO:0006568)	3.17681244
36	adaptation of signaling pathway (GO:0023058)	3.17562782
37	cochlea development (GO:0090102)	3.15927460
38	multicellular organism reproduction (GO:0032504)	3.15617446
39	regulation of non-canonical Wnt signaling pathway (GO:2000050)	3.15591263
40	epithelial cilium movement (GO:0003351)	3.11494327
41	metallo-sulfur cluster assembly (GO:0031163)	3.11078091
42	iron-sulfur cluster assembly (GO:0016226)	3.11078091
43	otic vesicle formation (GO:0030916)	3.10576303
44	hydrogen ion transmembrane transport (GO:1902600)	3.09603567
45	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.09475579
46	positive regulation of prostaglandin secretion (GO:0032308)	3.03851188
47	indolalkylamine metabolic process (GO:0006586)	3.03737407
48	viral transcription (GO:0019083)	3.03016105
49	protein neddylation (GO:0045116)	3.00208670
50	limb bud formation (GO:0060174)	2.99274680
51	translational termination (GO:0006415)	2.98650078
52	DNA replication checkpoint (GO:0000076)	2.98517786
53	protein-cofactor linkage (GO:0018065)	2.98396964
54	rRNA methylation (GO:0031167)	2.92009175
55	mannosylation (GO:0097502)	2.90861075
56	calcium ion-dependent exocytosis (GO:0017156)	2.90185433
57	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	2.87582667
58	neurofilament cytoskeleton organization (GO:0060052)	2.86997500
59	aerobic respiration (GO:0009060)	2.85295406
60	GTP biosynthetic process (GO:0006183)	2.84381661
61	regulation of acrosome reaction (GO:0060046)	2.83201349
62	proton transport (GO:0015992)	2.79576434
63	hydrogen transport (GO:0006818)	2.76094735
64	DNA double-strand break processing (GO:0000729)	2.74386456
65	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.72081536
66	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.72081536
67	neuron fate determination (GO:0048664)	2.71467583
68	embryonic body morphogenesis (GO:0010172)	2.69742731
69	keratinocyte proliferation (GO:0043616)	2.67194054
70	myoblast migration (GO:0051451)	2.66000458
71	protein polyglutamylation (GO:0018095)	2.65419316
72	piRNA metabolic process (GO:0034587)	2.64991958
73	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.64199602
74	cysteine metabolic process (GO:0006534)	2.63753449
75	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.63622124
76	ncRNA 3-end processing (GO:0043628)	2.63118728
77	DNA methylation involved in gamete generation (GO:0043046)	2.63059612
78	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.60448242
79	cotranslational protein targeting to membrane (GO:0006613)	2.60286976
80	histone H3-K9 demethylation (GO:0033169)	2.60084875
81	regulation of timing of cell differentiation (GO:0048505)	2.58884165
82	epoxygenase P450 pathway (GO:0019373)	2.57955913
83	translational elongation (GO:0006414)	2.57835432
84	protein targeting to ER (GO:0045047)	2.56566869
85	nitric oxide biosynthetic process (GO:0006809)	2.55613850
86	peptidyl-histidine modification (GO:0018202)	2.55585291
87	positive regulation of meiosis (GO:0045836)	2.54841101
88	centriole replication (GO:0007099)	2.54454372
89	cranial suture morphogenesis (GO:0060363)	2.54397774
90	toxin metabolic process (GO:0009404)	2.54219208
91	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.53840357
92	inner mitochondrial membrane organization (GO:0007007)	2.53752789
93	recombinational repair (GO:0000725)	2.51830100
94	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.51528425
95	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.50720413
96	NADH dehydrogenase complex assembly (GO:0010257)	2.50720413
97	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.50720413
98	UTP biosynthetic process (GO:0006228)	2.50514941
99	purine nucleotide salvage (GO:0032261)	2.50484464
100	cellular ketone body metabolic process (GO:0046950)	10.1962044

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.29250739
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.84221543
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.14150549
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.10138595
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.95027047
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.86348543
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.70893024
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.48280995
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.47411429
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.34980372
11	EWS_26573619_Chip-Seq_HEK293_Human	2.20363597
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.11962469
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.09816790
14	VDR_22108803_ChIP-Seq_LS180_Human	2.04438004
15	VDR_23849224_ChIP-Seq_CD4+_Human	1.99332989
16	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.95929492
17	GBX2_23144817_ChIP-Seq_PC3_Human	1.89739860
18	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.84474535
19	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.71817842
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.71540071
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.71281104
22	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.71088446
23	AR_21572438_ChIP-Seq_LNCaP_Human	1.70776335
24	MYC_19829295_ChIP-Seq_ESCs_Human	1.63698695
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62976440
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.60620806
27	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.54920522
28	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.52826577
29	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.51806897
30	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.49758868
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47435753
32	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.47318239
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44944531
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.44299184
35	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41555259
36	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.41090862
37	TAF2_19829295_ChIP-Seq_ESCs_Human	1.38330171
38	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.38290603
39	TP53_16413492_ChIP-PET_HCT116_Human	1.37976234
40	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.35751086
41	HTT_18923047_ChIP-ChIP_STHdh_Human	1.33014120
42	TP53_22573176_ChIP-Seq_HFKS_Human	1.29083494
43	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.28746982
44	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.28707270
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.28456736
46	AR_25329375_ChIP-Seq_VCAP_Human	1.26038690
47	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.24658953
48	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.24483563
49	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.21354991
50	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.20181800
51	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.20064375
52	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.19302589
53	TAF15_26573619_Chip-Seq_HEK293_Human	1.18364138
54	BCAT_22108803_ChIP-Seq_LS180_Human	1.17736404
55	HOXB7_26014856_ChIP-Seq_BT474_Human	1.16688345
56	ERA_21632823_ChIP-Seq_H3396_Human	1.16094583
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.14725000
58	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.14128672
59	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.13997696
60	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.12776942
61	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.12760036
62	ER_23166858_ChIP-Seq_MCF-7_Human	1.12439185
63	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.09865575
64	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.09679562
65	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.09152735
66	AR_20517297_ChIP-Seq_VCAP_Human	1.08577579
67	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.07550043
68	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.07168114
69	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.04999195
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.01980876
71	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.00895253
72	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.99325449
73	P53_21459846_ChIP-Seq_SAOS-2_Human	0.99092793
74	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.98994956
75	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97666657
76	NANOG_19829295_ChIP-Seq_ESCs_Human	0.96800767
77	SOX2_19829295_ChIP-Seq_ESCs_Human	0.96800767
78	ERG_20517297_ChIP-Seq_VCAP_Human	0.96354676
79	FUS_26573619_Chip-Seq_HEK293_Human	0.96329352
80	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.96317670
81	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.95993581
82	TCF4_23295773_ChIP-Seq_U87_Human	0.95333872
83	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.95143948
84	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.94920045
85	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94420040
86	GABP_19822575_ChIP-Seq_HepG2_Human	0.94317150
87	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.93991934
88	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.93418144
89	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.93418144
90	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.93067693
91	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.92539836
92	NANOG_20526341_ChIP-Seq_ESCs_Human	0.91901148
93	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.90935631
94	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.90638005
95	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.88806264
96	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.88742269
97	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.88093302
98	MYC_18940864_ChIP-ChIP_HL60_Human	0.87796651
99	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.87711064
100	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.86752693

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	5.42347490
2	MP0003950_abnormal_plasma_membrane	4.81868995
3	MP0000579_abnormal_nail_morphology	4.10910916
4	MP0003718_maternal_effect	3.28834856
5	MP0000566_synostosis	3.07593440
6	MP0003011_delayed_dark_adaptation	2.87707269
7	MP0004145_abnormal_muscle_electrophysio	2.66804712
8	MP0008872_abnormal_physiological_respon	2.51843490
9	MP0008877_abnormal_DNA_methylation	2.34385249
10	MP0008875_abnormal_xenobiotic_pharmacok	2.24196586
11	MP0004019_abnormal_vitamin_homeostasis	2.14604000
12	MP0009379_abnormal_foot_pigmentation	2.12625310
13	MP0003283_abnormal_digestive_organ	2.07177480
14	MP0005360_urolithiasis	2.00285050
15	MP0000762_abnormal_tongue_morphology	1.95449411
16	MP0009250_abnormal_appendicular_skeleto	1.83117161
17	MP0004142_abnormal_muscle_tone	1.81255234
18	MP0003786_premature_aging	1.76696830
19	MP0005410_abnormal_fertilization	1.65645247
20	MP0005551_abnormal_eye_electrophysiolog	1.60026420
21	MP0002272_abnormal_nervous_system	1.59368033
22	MP0000383_abnormal_hair_follicle	1.58952492
23	MP0002638_abnormal_pupillary_reflex	1.56752846
24	MP0004885_abnormal_endolymph	1.49334992
25	MP0009745_abnormal_behavioral_response	1.47558233
26	MP0008569_lethality_at_weaning	1.47178495
27	MP0005085_abnormal_gallbladder_physiolo	1.46054074
28	MP0004043_abnormal_pH_regulation	1.44434668
29	MP0001764_abnormal_homeostasis	1.44417191
30	MP0001881_abnormal_mammary_gland	1.40720887
31	MP0003880_abnormal_central_pattern	1.39361270
32	MP0001177_atelectasis	1.34412983
33	MP0004742_abnormal_vestibular_system	1.31134080
34	MP0001270_distended_abdomen	1.30996079
35	MP0003879_abnormal_hair_cell	1.28361225
36	MP0005395_other_phenotype	1.28330021
37	MP0006035_abnormal_mitochondrial_morpho	1.27523359
38	MP0001346_abnormal_lacrimal_gland	1.25065249
39	MP0000427_abnormal_hair_cycle	1.23974743
40	MP0001905_abnormal_dopamine_level	1.20123761
41	MP0000537_abnormal_urethra_morphology	1.19896112
42	MP0002733_abnormal_thermal_nociception	1.18338143
43	MP0005367_renal/urinary_system_phenotyp	1.18298082
44	MP0000516_abnormal_urinary_system	1.18298082
45	MP0003698_abnormal_male_reproductive	1.17509030
46	MP0003635_abnormal_synaptic_transmissio	1.15390000
47	MP0001929_abnormal_gametogenesis	1.13269957
48	MP0000778_abnormal_nervous_system	1.13168456
49	MP0010678_abnormal_skin_adnexa	1.10539337
50	MP0005167_abnormal_blood-brain_barrier	1.09986299
51	MP0002210_abnormal_sex_determination	1.09643629
52	MP0001765_abnormal_ion_homeostasis	1.09432697
53	MP0006036_abnormal_mitochondrial_physio	1.09131200
54	MP0000538_abnormal_urinary_bladder	1.08957725
55	MP0002735_abnormal_chemical_nociception	1.08869102
56	MP0008789_abnormal_olfactory_epithelium	1.08035826
57	MP0005084_abnormal_gallbladder_morpholo	1.07622023
58	MP0006292_abnormal_olfactory_placode	1.05832685
59	MP0001984_abnormal_olfaction	1.02630006
60	MP0000467_abnormal_esophagus_morphology	1.01300081
61	MP0002095_abnormal_skin_pigmentation	1.00498117
62	MP0001968_abnormal_touch/_nociception	0.99881850
63	MP0008058_abnormal_DNA_repair	0.98796837
64	MP0005377_hearing/vestibular/ear_phenot	0.98646622
65	MP0003878_abnormal_ear_physiology	0.98646622
66	MP0009046_muscle_twitch	0.97991499
67	MP0002909_abnormal_adrenal_gland	0.92854605
68	MP0001970_abnormal_pain_threshold	0.92309560
69	MP0006276_abnormal_autonomic_nervous	0.91980325
70	MP0003699_abnormal_female_reproductive	0.91192133
71	MP0008775_abnormal_heart_ventricle	0.89468134
72	MP0000627_abnormal_mammary_gland	0.87712968
73	MP0006072_abnormal_retinal_apoptosis	0.87535473
74	MP0003252_abnormal_bile_duct	0.86542887
75	MP0000653_abnormal_sex_gland	0.86015566
76	MP0001145_abnormal_male_reproductive	0.85900278
77	MP0010386_abnormal_urinary_bladder	0.83287457
78	MP0005266_abnormal_metabolism	0.83146178
79	MP0003385_abnormal_body_wall	0.80711728
80	MP0009643_abnormal_urine_homeostasis	0.79684597
81	MP0001486_abnormal_startle_reflex	0.79231805
82	MP0001666_abnormal_nutrient_absorption	0.78943593
83	MP0005409_darkened_coat_color	0.78554663
84	MP0002396_abnormal_hematopoietic_system	0.78464607
85	MP0003936_abnormal_reproductive_system	0.78159034
86	MP0002184_abnormal_innervation	0.77195526
87	MP0002102_abnormal_ear_morphology	0.74878892
88	MP0003938_abnormal_ear_development	0.73066341
89	MP0010094_abnormal_chromosome_stability	0.71596281
90	MP0003186_abnormal_redox_activity	0.70776820
91	MP0004134_abnormal_chest_morphology	0.70636046
92	MP0002752_abnormal_somatic_nervous	0.70603159
93	MP0002064_seizures	0.70200516
94	MP0000631_abnormal_neuroendocrine_gland	0.69262872
95	MP0003755_abnormal_palate_morphology	0.68437066
96	MP0002161_abnormal_fertility/fecundity	0.68386401
97	MP0002736_abnormal_nociception_after	0.68017312
98	MP0003787_abnormal_imprinting	0.66168807
99	MP0000026_abnormal_inner_ear	0.65975656
100	MP0003638_abnormal_response/metabolism_	0.65403653

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	3.59270933
2	Metaphyseal dysplasia (HP:0100255)	3.50612665
3	Hepatocellular necrosis (HP:0001404)	3.47812885
4	Alopecia of scalp (HP:0002293)	3.42863086
5	Parakeratosis (HP:0001036)	3.41490933
6	Stenosis of the external auditory canal (HP:0000402)	3.34690682
7	Pancreatic fibrosis (HP:0100732)	3.26803053
8	Broad distal phalanx of finger (HP:0009836)	3.22563224
9	Short tibia (HP:0005736)	3.18359696
10	Acute necrotizing encephalopathy (HP:0006965)	3.17698031
11	3-Methylglutaconic aciduria (HP:0003535)	3.11528861
12	Pancreatic cysts (HP:0001737)	3.10619214
13	Supernumerary spleens (HP:0009799)	3.08563238
14	Hypoplastic labia majora (HP:0000059)	3.08115825
15	Aplasia cutis congenita (HP:0001057)	3.06242071
16	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.05581986
17	Mitochondrial inheritance (HP:0001427)	3.04064411
18	Myokymia (HP:0002411)	3.02042801
19	Oral leukoplakia (HP:0002745)	3.00497666
20	Fused cervical vertebrae (HP:0002949)	2.99608572
21	Abnormal mitochondria in muscle tissue (HP:0008316)	2.84318086
22	Nasolacrimal duct obstruction (HP:0000579)	2.81984989
23	Abnormality of the labia majora (HP:0012881)	2.81814433
24	Hepatic necrosis (HP:0002605)	2.76333282
25	Plantar hyperkeratosis (HP:0007556)	2.75250119
26	Onycholysis (HP:0001806)	2.65093168
27	Gastrointestinal atresia (HP:0002589)	2.64696892
28	Abnormality of the parietal bone (HP:0002696)	2.63983392
29	Conical tooth (HP:0000698)	2.61599054
30	Median cleft lip (HP:0000161)	2.57921580
31	Increased CSF lactate (HP:0002490)	2.57786747
32	Chronic otitis media (HP:0000389)	2.55835655
33	Tinnitus (HP:0000360)	2.50558414
34	Palmoplantar hyperkeratosis (HP:0000972)	2.50339682
35	Keratoconus (HP:0000563)	2.50228742
36	Increased corneal curvature (HP:0100692)	2.50228742
37	Abnormality of incisor morphology (HP:0011063)	2.45664882
38	Aplasia involving bones of the extremities (HP:0009825)	2.45012514
39	Aplasia involving bones of the upper limbs (HP:0009823)	2.45012514
40	Aplasia of the phalanges of the hand (HP:0009802)	2.45012514
41	Progressive macrocephaly (HP:0004481)	2.42336813
42	Recurrent corneal erosions (HP:0000495)	2.41582876
43	Abnormality of midbrain morphology (HP:0002418)	2.36568893
44	Molar tooth sign on MRI (HP:0002419)	2.36568893
45	Palmar hyperkeratosis (HP:0010765)	2.33742325
46	Midline defect of the nose (HP:0004122)	2.32236951
47	Type I transferrin isoform profile (HP:0003642)	2.32159734
48	Sparse eyelashes (HP:0000653)	2.31965709
49	Aplastic anemia (HP:0001915)	2.31539238
50	Absent/shortened dynein arms (HP:0200106)	2.28992292
51	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.28992292
52	Synostosis of carpal bones (HP:0005048)	2.27376302
53	Agitation (HP:0000713)	2.21089635
54	Birth length less than 3rd percentile (HP:0003561)	2.19613232
55	Abnormality of the renal collecting system (HP:0004742)	2.18274947
56	Split foot (HP:0001839)	2.16130252
57	Duplicated collecting system (HP:0000081)	2.15635356
58	Acute encephalopathy (HP:0006846)	2.15179647
59	Reticulocytopenia (HP:0001896)	2.14547635
60	Abnormality of the lacrimal duct (HP:0011481)	2.13866264
61	Vacuolated lymphocytes (HP:0001922)	2.13459262
62	Trigonocephaly (HP:0000243)	2.13186395
63	Cutaneous finger syndactyly (HP:0010554)	2.12096786
64	Erythema (HP:0010783)	2.09177807
65	Abnormal respiratory motile cilium morphology (HP:0005938)	2.05455514
66	Abnormal respiratory epithelium morphology (HP:0012253)	2.05455514
67	Corneal erosion (HP:0200020)	2.05125051
68	Volvulus (HP:0002580)	2.04560743
69	Genital tract atresia (HP:0001827)	1.99882242
70	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.99312934
71	Postaxial foot polydactyly (HP:0001830)	1.99011997
72	Cerebral edema (HP:0002181)	1.97929848
73	Congenital, generalized hypertrichosis (HP:0004540)	1.97097847
74	Xerostomia (HP:0000217)	1.95307559
75	Medial flaring of the eyebrow (HP:0010747)	1.95048981
76	Follicular hyperkeratosis (HP:0007502)	1.94468994
77	Carpal synostosis (HP:0009702)	1.92411313
78	Abnormal ciliary motility (HP:0012262)	1.91111039
79	Partial duplication of thumb phalanx (HP:0009944)	1.87853351
80	Abnormal rod and cone electroretinograms (HP:0008323)	1.86397584
81	Abolished electroretinogram (ERG) (HP:0000550)	1.84927186
82	Action tremor (HP:0002345)	1.83595505
83	True hermaphroditism (HP:0010459)	1.83260787
84	Megalencephaly (HP:0001355)	1.82521750
85	Congenital stationary night blindness (HP:0007642)	1.81662719
86	Large eyes (HP:0001090)	1.81439963
87	Esophageal atresia (HP:0002032)	1.81355283
88	Lower limb hyperreflexia (HP:0002395)	1.79999694
89	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.78203186
90	Thick nail (HP:0001805)	1.77997625
91	Nail dystrophy (HP:0008404)	1.77979058
92	Horseshoe kidney (HP:0000085)	1.74929889
93	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.73846852
94	Increased serum lactate (HP:0002151)	1.72612737
95	Abnormality of the nasolacrimal system (HP:0000614)	1.72053106
96	Abnormality of nail color (HP:0100643)	1.70790226
97	Prominent metopic ridge (HP:0005487)	1.70416300
98	Hypoplasia of the pons (HP:0012110)	1.70211170
99	Abnormal protein N-linked glycosylation (HP:0012347)	1.70081139
100	Abnormal glycosylation (HP:0012345)	1.70081139

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	8.97469708
2	VRK2	3.77355530
3	WNK4	3.23000081
4	FGFR2	2.35008375
5	NUAK1	2.29765012
6	MAPK13	2.04003938
7	OXSR1	1.85298558
8	SMG1	1.72490873
9	GRK1	1.71502901
10	PDK2	1.66600864
11	CASK	1.65643496
12	NME2	1.63511589
13	STK39	1.61732949
14	FRK	1.60303226
15	PINK1	1.54932000
16	ACVR1B	1.54900388
17	KDR	1.54072260
18	VRK1	1.46733447
19	NME1	1.45906119
20	TXK	1.40620073
21	EPHA4	1.33773631
22	MAP3K9	1.32446003
23	BMPR1B	1.32128624
24	DAPK1	1.29346154
25	EIF2AK3	1.28217376
26	MST4	1.19276697
27	TGFBR1	1.18371244
28	ADRBK2	1.17756322
29	DYRK2	1.16555802
30	MST1R	1.14961466
31	SIK2	1.14872441
32	ZAK	1.12565861
33	MAP3K4	1.09144702
34	MARK1	1.08477764
35	EIF2AK2	1.05921765
36	ARAF	0.98831838
37	LRRK2	0.97212990
38	TESK2	0.97011149
39	MAP2K7	0.96451821
40	PHKG1	0.96165773
41	PHKG2	0.96165773
42	ADRBK1	0.92255392
43	ERBB3	0.89730755
44	CDK9	0.88878692
45	MINK1	0.87399169
46	MAPK12	0.86637289
47	GRK5	0.83158448
48	MAPKAPK5	0.80045542
49	PLK2	0.73946039
50	CDC7	0.72760565
51	BMPR2	0.72619302
52	ALK	0.71943683
53	STK11	0.71841719
54	AURKA	0.69418953
55	INSRR	0.66723695
56	EIF2AK1	0.66322031
57	LIMK1	0.61984209
58	IKBKB	0.59436961
59	TAF1	0.59274115
60	TNK2	0.58503034
61	ATR	0.58478976
62	MAP3K12	0.57985054
63	CSNK1A1	0.56510177
64	BCKDK	0.55696309
65	PRKCQ	0.55366041
66	CHEK2	0.52753980
67	PBK	0.52429601
68	PIK3CA	0.51822212
69	CAMKK2	0.49710995
70	CSNK1D	0.48822901
71	PKN1	0.47111913
72	ROCK2	0.46118161
73	PLK3	0.45483910
74	MAP2K6	0.44698625
75	PRKACA	0.42998369
76	CSNK2A2	0.42710103
77	EPHA3	0.41638678
78	AURKB	0.40515467
79	CHEK1	0.39453201
80	CAMK2B	0.37626751
81	CAMK2A	0.35679417
82	PRKCG	0.35608269
83	SIK3	0.34499761
84	WNK1	0.34443823
85	CAMKK1	0.32996297
86	PRKCE	0.31540855
87	CSNK1E	0.29814882
88	CAMK2D	0.29206307
89	CDK14	0.28338431
90	PRKCD	0.28165937
91	TLK1	0.27479177
92	ATM	0.26344255
93	SRPK1	0.24936577
94	SIK1	0.24608211
95	IKBKE	0.23782820
96	PRKCI	0.23072991
97	CAMK1D	0.22882933
98	LATS1	0.22057244
99	TBK1	0.21504907
100	TESK1	0.21364869

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	7.90439262
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.88183270
3	Parkinsons disease_Homo sapiens_hsa05012	3.61174118
4	Butanoate metabolism_Homo sapiens_hsa00650	3.31041492
5	Ribosome_Homo sapiens_hsa03010	2.87225499
6	Caffeine metabolism_Homo sapiens_hsa00232	2.78669876
7	Alzheimers disease_Homo sapiens_hsa05010	2.62069196
8	Basal transcription factors_Homo sapiens_hsa03022	2.50042617
9	Huntingtons disease_Homo sapiens_hsa05016	2.48395632
10	Homologous recombination_Homo sapiens_hsa03440	2.36020864
11	Tryptophan metabolism_Homo sapiens_hsa00380	2.31148361
12	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.30232009
13	Cardiac muscle contraction_Homo sapiens_hsa04260	2.10090064
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.04894237
15	Chemical carcinogenesis_Homo sapiens_hsa05204	1.93560611
16	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.85553236
17	Proteasome_Homo sapiens_hsa03050	1.75502187
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45675978
19	Protein export_Homo sapiens_hsa03060	1.43241754
20	RNA polymerase_Homo sapiens_hsa03020	1.42331413
21	Peroxisome_Homo sapiens_hsa04146	1.37636609
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34898547
23	Olfactory transduction_Homo sapiens_hsa04740	1.33238583
24	Steroid biosynthesis_Homo sapiens_hsa00100	1.27877374
25	DNA replication_Homo sapiens_hsa03030	1.24232466
26	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.18638305
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.08689092
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.07905959
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.06839435
30	Mismatch repair_Homo sapiens_hsa03430	1.06351469
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.04192780
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.97711757
33	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.96256538
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.96248365
35	Pyrimidine metabolism_Homo sapiens_hsa00240	0.92312230
36	Nicotine addiction_Homo sapiens_hsa05033	0.89635044
37	Nucleotide excision repair_Homo sapiens_hsa03420	0.86616797
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.84179792
39	Nitrogen metabolism_Homo sapiens_hsa00910	0.83975921
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.79094550
41	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.78712589
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.73513368
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.72676042
44	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.69692856
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.69551242
46	Metabolic pathways_Homo sapiens_hsa01100	0.69430807
47	Base excision repair_Homo sapiens_hsa03410	0.68453135
48	RNA degradation_Homo sapiens_hsa03018	0.67917396
49	Purine metabolism_Homo sapiens_hsa00230	0.66813165
50	One carbon pool by folate_Homo sapiens_hsa00670	0.66386458
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.65639127
52	Taste transduction_Homo sapiens_hsa04742	0.64723437
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.63465549
54	Fatty acid elongation_Homo sapiens_hsa00062	0.63364288
55	beta-Alanine metabolism_Homo sapiens_hsa00410	0.60950936
56	Retinol metabolism_Homo sapiens_hsa00830	0.54961606
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.53962078
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.52903249
59	RNA transport_Homo sapiens_hsa03013	0.51951323
60	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.49583133
61	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48316784
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46753594
63	Sulfur relay system_Homo sapiens_hsa04122	0.45052457
64	Propanoate metabolism_Homo sapiens_hsa00640	0.44788208
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44647843
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.44564465
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.41494303
68	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.40632427
69	Graft-versus-host disease_Homo sapiens_hsa05332	0.39353540
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.38787396
71	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.38610341
72	Glutathione metabolism_Homo sapiens_hsa00480	0.37575231
73	Phototransduction_Homo sapiens_hsa04744	0.37455946
74	Asthma_Homo sapiens_hsa05310	0.37384981
75	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.37073791
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.35911687
77	Primary immunodeficiency_Homo sapiens_hsa05340	0.32365710
78	Fatty acid degradation_Homo sapiens_hsa00071	0.30675971
79	Salivary secretion_Homo sapiens_hsa04970	0.27213816
80	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.27038872
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.25398312
82	Cholinergic synapse_Homo sapiens_hsa04725	0.23959858
83	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.23351141
84	Fatty acid metabolism_Homo sapiens_hsa01212	0.22653951
85	p53 signaling pathway_Homo sapiens_hsa04115	0.20965382
86	Serotonergic synapse_Homo sapiens_hsa04726	0.19355151
87	Hippo signaling pathway_Homo sapiens_hsa04390	0.19006611
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.18289991
89	ABC transporters_Homo sapiens_hsa02010	0.17637122
90	Other glycan degradation_Homo sapiens_hsa00511	0.16161356
91	Collecting duct acid secretion_Homo sapiens_hsa04966	0.14959029
92	Bile secretion_Homo sapiens_hsa04976	0.14735600
93	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.12174855
94	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.10642546
95	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.10585073
96	Pentose phosphate pathway_Homo sapiens_hsa00030	0.09497348
97	Protein digestion and absorption_Homo sapiens_hsa04974	0.09180524
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.08468149
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.07825388
100	Endocytosis_Homo sapiens_hsa04144	0.06350720

ATP5G1P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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