ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	7.60311539
2	dopaminergic neuron differentiation (GO:0071542)	6.84319212
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.36820176
4	cytidine deamination (GO:0009972)	6.33340113
5	cytidine metabolic process (GO:0046087)	6.33340113
6	cytidine catabolic process (GO:0006216)	6.33340113
7	ATP synthesis coupled proton transport (GO:0015986)	6.05364294
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.05364294
9	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.78441987
10	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.41130019
11	regulation of dopamine metabolic process (GO:0042053)	5.06083350
12	regulation of catecholamine metabolic process (GO:0042069)	5.06083350
13	protein complex biogenesis (GO:0070271)	4.85473860
14	mitochondrial respiratory chain complex assembly (GO:0033108)	4.80287332
15	chaperone-mediated protein transport (GO:0072321)	4.66232570
16	fucose catabolic process (GO:0019317)	4.57147162
17	L-fucose metabolic process (GO:0042354)	4.57147162
18	L-fucose catabolic process (GO:0042355)	4.57147162
19	positive regulation of interleukin-8 secretion (GO:2000484)	4.53261493
20	dopamine biosynthetic process (GO:0042416)	4.38035642
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.37897178
22	behavioral response to nicotine (GO:0035095)	4.17016915
23	respiratory electron transport chain (GO:0022904)	4.12451192
24	electron transport chain (GO:0022900)	4.11740386
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.07955918
26	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.07955918
27	NADH dehydrogenase complex assembly (GO:0010257)	4.07955918
28	sequestering of actin monomers (GO:0042989)	3.98908555
29	aldehyde catabolic process (GO:0046185)	3.88591643
30	response to insecticide (GO:0017085)	3.87427551
31	negative regulation by host of viral transcription (GO:0043922)	3.73850104
32	glyoxylate metabolic process (GO:0046487)	3.73659597
33	proteasome assembly (GO:0043248)	3.72936060
34	ATP biosynthetic process (GO:0006754)	3.69895079
35	protein neddylation (GO:0045116)	3.51860715
36	cytolysis (GO:0019835)	3.51480375
37	eosinophil chemotaxis (GO:0048245)	3.37599604
38	catechol-containing compound biosynthetic process (GO:0009713)	3.35822204
39	catecholamine biosynthetic process (GO:0042423)	3.35822204
40	cellular response to interleukin-15 (GO:0071350)	3.31172895
41	regulation of response to tumor cell (GO:0002834)	3.26608160
42	positive regulation of response to tumor cell (GO:0002836)	3.26608160
43	positive regulation of immune response to tumor cell (GO:0002839)	3.26608160
44	regulation of immune response to tumor cell (GO:0002837)	3.26608160
45	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.23654199
46	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.23530561
47	response to amphetamine (GO:0001975)	3.22762258
48	platelet dense granule organization (GO:0060155)	3.21510599
49	regulation of interleukin-12 biosynthetic process (GO:0045075)	3.16387498
50	cytochrome complex assembly (GO:0017004)	3.16358004
51	pyrimidine nucleoside catabolic process (GO:0046135)	3.10970259
52	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.08883761
53	termination of RNA polymerase III transcription (GO:0006386)	3.08883761
54	hydrogen ion transmembrane transport (GO:1902600)	3.07077980
55	eosinophil migration (GO:0072677)	3.04192024
56	dopamine metabolic process (GO:0042417)	3.02140862
57	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.99534459
58	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.95387129
59	water-soluble vitamin biosynthetic process (GO:0042364)	2.94945025
60	serine family amino acid catabolic process (GO:0009071)	2.94494795
61	regulation of interleukin-8 secretion (GO:2000482)	2.93238928
62	sulfur amino acid catabolic process (GO:0000098)	2.92703314
63	negative regulation of B cell apoptotic process (GO:0002903)	2.89918306
64	proton transport (GO:0015992)	2.88111952
65	hydrogen transport (GO:0006818)	2.84522720
66	histone-serine phosphorylation (GO:0035404)	2.82674539
67	response to amine (GO:0014075)	2.74298944
68	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.72740377
69	protein homotrimerization (GO:0070207)	2.72192116
70	respiratory chain complex IV assembly (GO:0008535)	2.72138348
71	dentate gyrus development (GO:0021542)	2.72005156
72	GMP metabolic process (GO:0046037)	2.71896104
73	regulation of lymphocyte chemotaxis (GO:1901623)	2.71805811
74	negative regulation of membrane potential (GO:0045837)	2.69926241
75	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.66291231
76	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.60928334
77	positive regulation of defense response to virus by host (GO:0002230)	2.57822661
78	pyrimidine-containing compound catabolic process (GO:0072529)	2.57252023
79	response to interleukin-15 (GO:0070672)	2.56715204
80	protein targeting to mitochondrion (GO:0006626)	2.55481643
81	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.55054643
82	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.55054643
83	nucleoside triphosphate biosynthetic process (GO:0009142)	2.55004154
84	deoxyribose phosphate biosynthetic process (GO:0046385)	2.54075757
85	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.54075757
86	regulation of cellular amine metabolic process (GO:0033238)	2.53750127
87	potassium ion export (GO:0071435)	2.53503323
88	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.52997990
89	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.52969354
90	ribosomal small subunit assembly (GO:0000028)	2.52568112
91	spliceosomal snRNP assembly (GO:0000387)	2.52358172
92	fucose metabolic process (GO:0006004)	2.52195527
93	translesion synthesis (GO:0019985)	2.48553448
94	regulation of cellular amino acid metabolic process (GO:0006521)	2.47499334
95	natural killer cell activation involved in immune response (GO:0002323)	2.47255680
96	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.45231588
97	peristalsis (GO:0030432)	2.43197450
98	blood coagulation, intrinsic pathway (GO:0007597)	2.41049005
99	signal peptide processing (GO:0006465)	2.38774251
100	establishment of protein localization to mitochondrion (GO:0072655)	2.38388882

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	7.93085892
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	4.91356529
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.95770966
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.23798547
5	VDR_22108803_ChIP-Seq_LS180_Human	3.18401668
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.78491569
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.72899891
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.66709619
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.48881669
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.44212332
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.37721784
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.33853296
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.30142992
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.28162112
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.20717073
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.20688916
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.16983563
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.13610191
19	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.98288986
20	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.91556422
21	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.78794881
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.74643217
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.71418540
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.66618383
25	HTT_18923047_ChIP-ChIP_STHdh_Human	1.58116193
26	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.57343840
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.52755278
28	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.50952935
29	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.49607758
30	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.49587941
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.46687558
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.41839787
33	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.41807159
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.40993828
35	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.38585696
36	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.37395486
37	MYC_19829295_ChIP-Seq_ESCs_Human	1.37025163
38	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.36277996
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35832815
40	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35832815
41	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.35314719
42	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.34769481
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.34398328
44	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.29361356
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.29020896
46	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.28154721
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23483674
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23483674
49	TAF2_19829295_ChIP-Seq_ESCs_Human	1.23390976
50	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.23147386
51	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.22958561
52	AR_20517297_ChIP-Seq_VCAP_Human	1.22825083
53	NANOG_20526341_ChIP-Seq_ESCs_Human	1.22317787
54	FOXP3_21729870_ChIP-Seq_TREG_Human	1.21586184
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18551617
56	EWS_26573619_Chip-Seq_HEK293_Human	1.17255611
57	CTCF_20526341_ChIP-Seq_ESCs_Human	1.16514658
58	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.16489646
59	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16240657
60	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.11119143
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10408667
62	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.05469180
63	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.05142827
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04359577
65	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.03515659
66	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.02802088
67	GATA3_26560356_Chip-Seq_TH2_Human	1.01844781
68	FUS_26573619_Chip-Seq_HEK293_Human	0.99585781
69	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.98778262
70	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.98014511
71	P300_19829295_ChIP-Seq_ESCs_Human	0.97157302
72	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95680766
73	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.93655538
74	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.92940976
75	ELK1_19687146_ChIP-ChIP_HELA_Human	0.92204195
76	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.91986105
77	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.91090924
78	ERA_21632823_ChIP-Seq_H3396_Human	0.91063417
79	RUNX_20019798_ChIP-Seq_JUKART_Human	0.90766990
80	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.90479204
81	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.90443533
82	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.88968819
83	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.88531439
84	NCOR_22424771_ChIP-Seq_293T_Human	0.88483816
85	ER_23166858_ChIP-Seq_MCF-7_Human	0.88351126
86	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.88108025
87	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.87574225
88	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.86476968
89	GBX2_23144817_ChIP-Seq_PC3_Human	0.85446248
90	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.85315583
91	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.84952308
92	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.84117449
93	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.82245312
94	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.82003005
95	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.81236211
96	ERG_20517297_ChIP-Seq_VCAP_Human	0.80664213
97	OCT4_20526341_ChIP-Seq_ESCs_Human	0.80144243
98	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.79425637
99	TCF4_22108803_ChIP-Seq_LS180_Human	0.78757910
100	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.77827172

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	6.47864700
2	MP0004145_abnormal_muscle_electrophysio	4.09108232
3	MP0008004_abnormal_stomach_pH	3.44256892
4	MP0003693_abnormal_embryo_hatching	2.83992711
5	MP0004147_increased_porphyrin_level	2.79100645
6	MP0002102_abnormal_ear_morphology	2.64736593
7	MP0002876_abnormal_thyroid_physiology	2.58015984
8	MP0002138_abnormal_hepatobiliary_system	2.57064203
9	MP0002163_abnormal_gland_morphology	2.52967992
10	MP0002139_abnormal_hepatobiliary_system	2.41059604
11	MP0008875_abnormal_xenobiotic_pharmacok	2.30184868
12	MP0003315_abnormal_perineum_morphology	2.21989010
13	MP0004742_abnormal_vestibular_system	2.18105009
14	MP0009333_abnormal_splenocyte_physiolog	2.05776992
15	MP0003880_abnormal_central_pattern	1.96707261
16	MP0003183_abnormal_peptide_metabolism	1.95353876
17	MP0009745_abnormal_behavioral_response	1.93809317
18	MP0002938_white_spotting	1.85238494
19	MP0003195_calcinosis	1.72222648
20	MP0001666_abnormal_nutrient_absorption	1.64252948
21	MP0008877_abnormal_DNA_methylation	1.63756263
22	MP0003011_delayed_dark_adaptation	1.57906573
23	MP0001905_abnormal_dopamine_level	1.56132972
24	MP0009046_muscle_twitch	1.51903914
25	MP0003638_abnormal_response/metabolism_	1.50823483
26	MP0005165_increased_susceptibility_to	1.48086051
27	MP0005671_abnormal_response_to	1.46673067
28	MP0005645_abnormal_hypothalamus_physiol	1.41982509
29	MP0005377_hearing/vestibular/ear_phenot	1.41752182
30	MP0003878_abnormal_ear_physiology	1.41752182
31	MP0008007_abnormal_cellular_replicative	1.40483060
32	MP0000569_abnormal_digit_pigmentation	1.40322437
33	MP0009785_altered_susceptibility_to	1.39266834
34	MP0005379_endocrine/exocrine_gland_phen	1.33897306
35	MP0006082_CNS_inflammation	1.33563809
36	MP0003186_abnormal_redox_activity	1.31501727
37	MP0001440_abnormal_grooming_behavior	1.30658560
38	MP0000372_irregular_coat_pigmentation	1.30632793
39	MP0005365_abnormal_bile_salt	1.29026681
40	MP0005551_abnormal_eye_electrophysiolog	1.22755595
41	MP0000537_abnormal_urethra_morphology	1.22235118
42	MP0001835_abnormal_antigen_presentation	1.15970904
43	MP0005084_abnormal_gallbladder_morpholo	1.14439353
44	MP0003866_abnormal_defecation	1.12501423
45	MP0002132_abnormal_respiratory_system	1.10724668
46	MP0003806_abnormal_nucleotide_metabolis	1.08518364
47	MP0005085_abnormal_gallbladder_physiolo	1.07783971
48	MP0006036_abnormal_mitochondrial_physio	1.07526858
49	MP0008872_abnormal_physiological_respon	1.06402798
50	MP0006072_abnormal_retinal_apoptosis	1.06395227
51	MP0001800_abnormal_humoral_immune	1.05652264
52	MP0002736_abnormal_nociception_after	1.04727618
53	MP0002148_abnormal_hypersensitivity_rea	1.04255262
54	MP0005670_abnormal_white_adipose	1.02997347
55	MP0003718_maternal_effect	1.02901190
56	MP0002184_abnormal_innervation	1.01714900
57	MP0010030_abnormal_orbit_morphology	1.01224252
58	MP0002064_seizures	0.99624768
59	MP0001529_abnormal_vocalization	0.95925711
60	MP0003938_abnormal_ear_development	0.94289591
61	MP0005360_urolithiasis	0.93216295
62	MP0001968_abnormal_touch/_nociception	0.92869645
63	MP0003075_altered_response_to	0.91928002
64	MP0002420_abnormal_adaptive_immunity	0.90993475
65	MP0002837_dystrophic_cardiac_calcinosis	0.90774552
66	MP0002272_abnormal_nervous_system	0.90521528
67	MP0004885_abnormal_endolymph	0.88115003
68	MP0005025_abnormal_response_to	0.87617325
69	MP0001502_abnormal_circadian_rhythm	0.87404583
70	MP0003045_fibrosis	0.85744019
71	MP0005332_abnormal_amino_acid	0.85540079
72	MP0009379_abnormal_foot_pigmentation	0.85179201
73	MP0001542_abnormal_bone_strength	0.85143855
74	MP0002067_abnormal_sensory_capabilities	0.84789442
75	MP0001819_abnormal_immune_cell	0.83106930
76	MP0005410_abnormal_fertilization	0.82913867
77	MP0005367_renal/urinary_system_phenotyp	0.80490727
78	MP0000516_abnormal_urinary_system	0.80490727
79	MP0002723_abnormal_immune_serum	0.79987080
80	MP0005646_abnormal_pituitary_gland	0.79888514
81	MP0002572_abnormal_emotion/affect_behav	0.79520854
82	MP0003868_abnormal_feces_composition	0.76072868
83	MP0002733_abnormal_thermal_nociception	0.75529031
84	MP0000427_abnormal_hair_cycle	0.74219544
85	MP0001790_abnormal_immune_system	0.73658159
86	MP0005387_immune_system_phenotype	0.73658159
87	MP0010386_abnormal_urinary_bladder	0.73603219
88	MP0001485_abnormal_pinna_reflex	0.71416843
89	MP0000026_abnormal_inner_ear	0.71296374
90	MP0005174_abnormal_tail_pigmentation	0.70659509
91	MP0000716_abnormal_immune_system	0.70481640
92	MP0002557_abnormal_social/conspecific_i	0.70157972
93	MP0006276_abnormal_autonomic_nervous	0.69911979
94	MP0009763_increased_sensitivity_to	0.69569143
95	MP0005000_abnormal_immune_tolerance	0.68966015
96	MP0002722_abnormal_immune_system	0.68292968
97	MP0001486_abnormal_startle_reflex	0.67520978
98	MP0005636_abnormal_mineral_homeostasis	0.67058431
99	MP0000538_abnormal_urinary_bladder	0.65726247
100	MP0001119_abnormal_female_reproductive	0.64397405

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.64134439
2	Abnormal mitochondria in muscle tissue (HP:0008316)	5.17494461
3	Acute encephalopathy (HP:0006846)	5.10482195
4	Progressive macrocephaly (HP:0004481)	4.73547164
5	Mitochondrial inheritance (HP:0001427)	4.50251965
6	Aplastic anemia (HP:0001915)	3.86882301
7	Increased CSF lactate (HP:0002490)	3.79945436
8	Cerebral edema (HP:0002181)	3.60461016
9	Renal cortical cysts (HP:0000803)	3.56494372
10	Testicular atrophy (HP:0000029)	3.37051701
11	Optic disc pallor (HP:0000543)	3.28338476
12	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.28021430
13	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.28021430
14	Hepatic necrosis (HP:0002605)	3.17089808
15	Abnormality of the renal cortex (HP:0011035)	3.02686487
16	Hepatocellular necrosis (HP:0001404)	3.01322449
17	Limb dystonia (HP:0002451)	3.00345251
18	Oligodactyly (hands) (HP:0001180)	3.00022145
19	T lymphocytopenia (HP:0005403)	2.97487573
20	Congenital, generalized hypertrichosis (HP:0004540)	2.93557097
21	Abnormality of T cell number (HP:0011839)	2.92909226
22	Abnormality of binocular vision (HP:0011514)	2.91699797
23	Diplopia (HP:0000651)	2.91699797
24	Congenital stationary night blindness (HP:0007642)	2.91456749
25	Poor speech (HP:0002465)	2.77310709
26	Generalized aminoaciduria (HP:0002909)	2.73418835
27	Reduced antithrombin III activity (HP:0001976)	2.68909286
28	Leukodystrophy (HP:0002415)	2.67145615
29	Increased intramyocellular lipid droplets (HP:0012240)	2.67120068
30	Molar tooth sign on MRI (HP:0002419)	2.64576257
31	Abnormality of midbrain morphology (HP:0002418)	2.64576257
32	Lactic acidosis (HP:0003128)	2.61979751
33	Renal Fanconi syndrome (HP:0001994)	2.61866684
34	Increased serum lactate (HP:0002151)	2.51753699
35	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.46497980
36	Attenuation of retinal blood vessels (HP:0007843)	2.41815244
37	Abnormal number of erythroid precursors (HP:0012131)	2.41071995
38	Abnormality of T cells (HP:0002843)	2.35423760
39	Nausea (HP:0002018)	2.32735795
40	Large eyes (HP:0001090)	2.27161117
41	Abnormal pupillary function (HP:0007686)	2.26392561
42	Increased hepatocellular lipid droplets (HP:0006565)	2.26357153
43	Abnormality of the 2nd finger (HP:0004100)	2.25462369
44	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.19125589
45	Oligodactyly (HP:0012165)	2.18663129
46	Delayed CNS myelination (HP:0002188)	2.17716185
47	Exercise intolerance (HP:0003546)	2.15979760
48	Respiratory failure (HP:0002878)	2.15406964
49	3-Methylglutaconic aciduria (HP:0003535)	2.14064576
50	Hypoplasia of the uterus (HP:0000013)	2.12526530
51	Severe combined immunodeficiency (HP:0004430)	2.06863141
52	Abnormality of the prostate (HP:0008775)	2.06355010
53	Type II lissencephaly (HP:0007260)	2.05820334
54	IgG deficiency (HP:0004315)	2.02301407
55	Concave nail (HP:0001598)	2.00924221
56	Lethargy (HP:0001254)	1.99980870
57	Macrocytic anemia (HP:0001972)	1.99914712
58	Recurrent cutaneous fungal infections (HP:0011370)	1.96561645
59	Chronic mucocutaneous candidiasis (HP:0002728)	1.96561645
60	Abnormality of T cell physiology (HP:0011840)	1.95581221
61	Abnormality of renal resorption (HP:0011038)	1.94237154
62	Chronic obstructive pulmonary disease (HP:0006510)	1.93445029
63	Obstructive lung disease (HP:0006536)	1.93445029
64	Abnormality of cells of the erythroid lineage (HP:0012130)	1.93153240
65	Gout (HP:0001997)	1.91446144
66	Nephronophthisis (HP:0000090)	1.89792692
67	Glycosuria (HP:0003076)	1.89286509
68	Abnormality of urine glucose concentration (HP:0011016)	1.89286509
69	Increased muscle lipid content (HP:0009058)	1.89258508
70	X-linked dominant inheritance (HP:0001423)	1.88563460
71	IgM deficiency (HP:0002850)	1.87871352
72	IgA deficiency (HP:0002720)	1.87078196
73	Recurrent corneal erosions (HP:0000495)	1.83345211
74	Abnormality of the renal medulla (HP:0100957)	1.83156296
75	Stomatitis (HP:0010280)	1.82366698
76	Prolonged partial thromboplastin time (HP:0003645)	1.82251280
77	Parakeratosis (HP:0001036)	1.79999219
78	Elevated erythrocyte sedimentation rate (HP:0003565)	1.79865871
79	Vacuolated lymphocytes (HP:0001922)	1.78255045
80	Aplasia/hypoplasia of the uterus (HP:0008684)	1.76557305
81	Lipid accumulation in hepatocytes (HP:0006561)	1.75434248
82	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.74668467
83	Large for gestational age (HP:0001520)	1.74593705
84	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.74522461
85	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.74254705
86	Thyroiditis (HP:0100646)	1.73482591
87	Pancytopenia (HP:0001876)	1.73337726
88	Recurrent fungal infections (HP:0002841)	1.72620966
89	Chronic diarrhea (HP:0002028)	1.66882523
90	Abnormality of male internal genitalia (HP:0000022)	1.66333698
91	Abolished electroretinogram (ERG) (HP:0000550)	1.65407407
92	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.65158233
93	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.64820272
94	Neonatal hypoglycemia (HP:0001998)	1.64126159
95	Combined immunodeficiency (HP:0005387)	1.62962814
96	Truncus arteriosus (HP:0001660)	1.61717888
97	CNS demyelination (HP:0007305)	1.61280267
98	Pendular nystagmus (HP:0012043)	1.60203378
99	Mediastinal lymphadenopathy (HP:0100721)	1.59195879
100	Purpura (HP:0000979)	1.59141821

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.56102568
2	INSRR	3.36913279
3	WNK3	3.22215617
4	ZAK	3.19380111
5	MARK1	3.15101969
6	EPHB2	3.02014060
7	PHKG1	2.62238985
8	PHKG2	2.62238985
9	DYRK2	2.60201928
10	BCKDK	2.60009205
11	TXK	2.38407443
12	RPS6KA4	2.14670463
13	PIK3CA	2.13380683
14	VRK1	2.09109965
15	TAF1	1.99634346
16	TESK2	1.96864441
17	MAP4K2	1.90931156
18	NTRK3	1.80896365
19	MAPK13	1.74020434
20	BMPR1B	1.58880970
21	DAPK2	1.56135365
22	PIK3CG	1.55483972
23	ADRBK2	1.55442275
24	TRIB3	1.51759318
25	OXSR1	1.49525829
26	FES	1.45969546
27	KDR	1.45769856
28	NME1	1.42923472
29	CDC7	1.33599215
30	KIT	1.33594480
31	STK39	1.28615471
32	MAP2K6	1.27545287
33	EIF2AK2	1.25857498
34	GRK1	1.25629575
35	CASK	1.24554559
36	TLK1	1.23275379
37	MAP4K1	1.21744358
38	BMPR2	1.20638760
39	SIK2	1.20151610
40	BUB1	1.18579456
41	CDK8	1.14662531
42	STK38L	1.12112857
43	ITK	1.11392639
44	WNK4	1.03696914
45	NUAK1	1.02475912
46	ABL2	0.98589467
47	EIF2AK3	0.95498039
48	MAP3K4	0.93746072
49	MKNK2	0.84959524
50	LIMK1	0.84175446
51	SYK	0.82221879
52	CDK19	0.80868719
53	PRKCG	0.79726824
54	CHEK2	0.79125508
55	TTK	0.74749015
56	MAP2K7	0.74052049
57	PRKCQ	0.73241297
58	KSR1	0.68557342
59	CSF1R	0.68456820
60	ADRBK1	0.67559454
61	TEC	0.67161374
62	TESK1	0.66682586
63	CLK1	0.64170724
64	ILK	0.64064522
65	PLK3	0.61759658
66	PRKCD	0.59389598
67	FRK	0.57385684
68	PKN1	0.52439309
69	DYRK1A	0.50991917
70	GRK5	0.50155191
71	PRKCE	0.50112821
72	SCYL2	0.49444117
73	RPS6KA5	0.49015185
74	MKNK1	0.48893892
75	TBK1	0.45908304
76	LYN	0.45830795
77	IKBKB	0.45485179
78	TAOK3	0.45226457
79	MAPK15	0.44900427
80	CSNK2A1	0.44656116
81	MAPKAPK3	0.43699716
82	ATR	0.43374427
83	CSNK1G2	0.42503749
84	SRPK1	0.40777141
85	MAPK12	0.38065575
86	CSNK1G3	0.35721853
87	TGFBR1	0.35205466
88	CSNK1A1	0.35138187
89	NME2	0.35116119
90	PRKCA	0.34835851
91	CAMK2A	0.32703984
92	LCK	0.30953458
93	GRK7	0.30428100
94	MUSK	0.30168758
95	PRKG1	0.28975540
96	MAP2K1	0.28354990
97	OBSCN	0.27376747
98	CDK3	0.26850305
99	PRKCI	0.24721901
100	CSNK2A2	0.24703424

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.79129936
2	Protein export_Homo sapiens_hsa03060	3.36046967
3	Proteasome_Homo sapiens_hsa03050	3.35121443
4	Graft-versus-host disease_Homo sapiens_hsa05332	3.30161785
5	Parkinsons disease_Homo sapiens_hsa05012	3.12296649
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.10261311
7	Allograft rejection_Homo sapiens_hsa05330	2.46057017
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.27022777
9	Ribosome_Homo sapiens_hsa03010	2.26213765
10	Alzheimers disease_Homo sapiens_hsa05010	2.24083514
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.21615085
12	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.19856216
13	RNA polymerase_Homo sapiens_hsa03020	2.15767658
14	Type I diabetes mellitus_Homo sapiens_hsa04940	2.11321941
15	Antigen processing and presentation_Homo sapiens_hsa04612	2.11243706
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.90725814
17	Huntingtons disease_Homo sapiens_hsa05016	1.85420229
18	Asthma_Homo sapiens_hsa05310	1.79518377
19	Rheumatoid arthritis_Homo sapiens_hsa05323	1.77364384
20	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.69271750
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.66990822
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.57753313
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.55767051
24	Phototransduction_Homo sapiens_hsa04744	1.47351236
25	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.39224844
26	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.38221752
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.27000151
28	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.24563869
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.24393212
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.21429282
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.15803614
32	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.14808786
33	Nicotine addiction_Homo sapiens_hsa05033	1.11547370
34	One carbon pool by folate_Homo sapiens_hsa00670	1.10963323
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.05532504
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.00565411
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.99449653
38	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.96590879
39	Butanoate metabolism_Homo sapiens_hsa00650	0.95775246
40	Linoleic acid metabolism_Homo sapiens_hsa00591	0.94171465
41	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.93947429
42	Collecting duct acid secretion_Homo sapiens_hsa04966	0.90320393
43	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.90054159
44	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.90033967
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89298379
46	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.88576118
47	Mismatch repair_Homo sapiens_hsa03430	0.88243076
48	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.87510379
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.87325365
50	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.87156279
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86598655
52	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.83348961
53	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.82833787
54	DNA replication_Homo sapiens_hsa03030	0.82701640
55	Peroxisome_Homo sapiens_hsa04146	0.81823734
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.81307715
57	Spliceosome_Homo sapiens_hsa03040	0.81219007
58	Retinol metabolism_Homo sapiens_hsa00830	0.80292830
59	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.73953495
60	Pyruvate metabolism_Homo sapiens_hsa00620	0.73905067
61	Base excision repair_Homo sapiens_hsa03410	0.70379296
62	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.70217065
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.68897790
64	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.67630870
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67363054
66	Salmonella infection_Homo sapiens_hsa05132	0.65502165
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62066445
68	Caffeine metabolism_Homo sapiens_hsa00232	0.61620969
69	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.60532862
70	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.59535857
71	Fanconi anemia pathway_Homo sapiens_hsa03460	0.59052209
72	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.58484277
73	Purine metabolism_Homo sapiens_hsa00230	0.58104938
74	Metabolic pathways_Homo sapiens_hsa01100	0.56698366
75	Homologous recombination_Homo sapiens_hsa03440	0.55340587
76	Ether lipid metabolism_Homo sapiens_hsa00565	0.49228363
77	Glutathione metabolism_Homo sapiens_hsa00480	0.44008816
78	Leishmaniasis_Homo sapiens_hsa05140	0.41251382
79	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.40769450
80	Arginine and proline metabolism_Homo sapiens_hsa00330	0.40600064
81	Phenylalanine metabolism_Homo sapiens_hsa00360	0.39770791
82	Viral myocarditis_Homo sapiens_hsa05416	0.39390459
83	Morphine addiction_Homo sapiens_hsa05032	0.38953100
84	GABAergic synapse_Homo sapiens_hsa04727	0.36511789
85	Salivary secretion_Homo sapiens_hsa04970	0.35283787
86	Complement and coagulation cascades_Homo sapiens_hsa04610	0.35107786
87	Basal transcription factors_Homo sapiens_hsa03022	0.33898738
88	Sulfur metabolism_Homo sapiens_hsa00920	0.32352238
89	Olfactory transduction_Homo sapiens_hsa04740	0.32011111
90	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.29930757
91	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.29800115
92	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.28662868
93	Tryptophan metabolism_Homo sapiens_hsa00380	0.28355686
94	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.27615155
95	RNA degradation_Homo sapiens_hsa03018	0.27130202
96	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.26962260
97	Propanoate metabolism_Homo sapiens_hsa00640	0.26555741
98	Tyrosine metabolism_Homo sapiens_hsa00350	0.22933177
99	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.22846402
100	Nucleotide excision repair_Homo sapiens_hsa03420	0.22506060

ATP5G1P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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