ATP5G2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to gravity (GO:0009629)6.47624785
2response to xenobiotic stimulus (GO:0009410)6.27920043
3regulation of skeletal muscle contraction (GO:0014819)6.25932648
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.60338078
5ATP synthesis coupled proton transport (GO:0015986)5.60338078
6cullin deneddylation (GO:0010388)4.95536781
7ribosomal small subunit assembly (GO:0000028)4.92078958
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.77165282
9negative regulation of muscle hypertrophy (GO:0014741)4.67586352
10skeletal muscle tissue regeneration (GO:0043403)4.65807048
11urate metabolic process (GO:0046415)4.45049144
12protein deneddylation (GO:0000338)4.05593408
13viral transcription (GO:0019083)4.00192646
14skeletal muscle adaptation (GO:0043501)3.87846244
15regulation of memory T cell differentiation (GO:0043380)3.87703860
16translational termination (GO:0006415)3.83033228
17response to pheromone (GO:0019236)3.78992380
18translational elongation (GO:0006414)3.78177732
19striated muscle atrophy (GO:0014891)3.76714571
20protein neddylation (GO:0045116)3.66489939
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.56326461
22tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.56326461
23actin-myosin filament sliding (GO:0033275)3.55968148
24muscle filament sliding (GO:0030049)3.55968148
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55617842
26mitochondrial respiratory chain complex I assembly (GO:0032981)3.55617842
27NADH dehydrogenase complex assembly (GO:0010257)3.55617842
28purine nucleoside triphosphate biosynthetic process (GO:0009145)3.55002914
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53392177
30respiratory electron transport chain (GO:0022904)3.52963553
31regulation of DNA endoreduplication (GO:0032875)3.51277016
32protein complex biogenesis (GO:0070271)3.50547966
33electron transport chain (GO:0022900)3.50376941
34ATP biosynthetic process (GO:0006754)3.44232431
35protein targeting to ER (GO:0045047)3.43705222
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.43402254
37musculoskeletal movement (GO:0050881)3.42842527
38multicellular organismal movement (GO:0050879)3.42842527
39purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.42715586
40cornea development in camera-type eye (GO:0061303)3.42618052
41spinal cord association neuron differentiation (GO:0021527)3.41162799
42muscle atrophy (GO:0014889)3.40482135
43fusion of sperm to egg plasma membrane (GO:0007342)3.40244869
44GTP biosynthetic process (GO:0006183)3.37912245
45mechanosensory behavior (GO:0007638)3.34411550
46mitochondrial respiratory chain complex assembly (GO:0033108)3.31394240
47cotranslational protein targeting to membrane (GO:0006613)3.30754776
48protein localization to endoplasmic reticulum (GO:0070972)3.26432418
49establishment of protein localization to endoplasmic reticulum (GO:0072599)3.25397584
50regulation of germinal center formation (GO:0002634)3.19533273
51negative regulation of oligodendrocyte differentiation (GO:0048715)3.15988492
52regulation of glomerulus development (GO:0090192)3.07287111
53sulfation (GO:0051923)3.04392856
54negative regulation of nitric-oxide synthase activity (GO:0051001)3.03551332
55negative regulation of gene silencing (GO:0060969)3.02812422
56auditory receptor cell differentiation (GO:0042491)3.02223389
57mesonephros development (GO:0001823)3.00584740
58regulation of female gonad development (GO:2000194)2.98850488
59actin-mediated cell contraction (GO:0070252)2.98132468
60platelet dense granule organization (GO:0060155)2.91371161
61cellular protein complex disassembly (GO:0043624)2.88098613
62lung secretory cell differentiation (GO:0061140)2.86648962
63sequestering of actin monomers (GO:0042989)2.85508877
64viral life cycle (GO:0019058)2.83903977
65flavonoid metabolic process (GO:0009812)2.82600403
66ribonucleoside triphosphate biosynthetic process (GO:0009201)2.82577350
67somite development (GO:0061053)2.80850929
68DNA deamination (GO:0045006)2.80098392
69NIK/NF-kappaB signaling (GO:0038061)2.79604904
70ovulation cycle (GO:0042698)2.79591208
71dentate gyrus development (GO:0021542)2.79061245
72pharyngeal system development (GO:0060037)2.76724245
73water-soluble vitamin biosynthetic process (GO:0042364)2.76422329
74nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.75994286
75translational initiation (GO:0006413)2.75262996
76endoderm formation (GO:0001706)2.74870347
77regulation of timing of cell differentiation (GO:0048505)2.74843904
78plasma membrane fusion (GO:0045026)2.74175118
79killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.72989931
80disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.72989931
81response to muscle activity (GO:0014850)2.72783439
82cell proliferation in forebrain (GO:0021846)2.72448868
83translation (GO:0006412)2.71476305
84positive regulation of cell fate commitment (GO:0010455)2.71072170
85negative regulation of oxidoreductase activity (GO:0051354)2.68854920
86regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.67036525
87protein polyglutamylation (GO:0018095)2.66220489
88regulation of female receptivity (GO:0045924)2.65737867
89negative regulation of monooxygenase activity (GO:0032769)2.64788575
90regulation of transmission of nerve impulse (GO:0051969)2.64661546
91behavioral response to nicotine (GO:0035095)2.59981202
92auditory behavior (GO:0031223)2.59181455
93positive regulation of glomerulus development (GO:0090193)2.58186340
94nephron epithelium morphogenesis (GO:0072088)2.56347703
95nephron tubule morphogenesis (GO:0072078)2.56347703
96positive regulation of cardiac muscle cell differentiation (GO:2000727)2.56245666
97cellular response to ATP (GO:0071318)2.55275459
98regulation of development, heterochronic (GO:0040034)2.54926018
99UTP biosynthetic process (GO:0006228)2.53289726
100hydrogen ion transmembrane transport (GO:1902600)2.49639729

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.17366616
2VDR_22108803_ChIP-Seq_LS180_Human5.11260044
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.02335962
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.28435237
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.04390545
6CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.44880430
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.15633360
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14870277
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.10298080
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.08675584
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.06289270
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.06257851
13ELK1_19687146_ChIP-ChIP_HELA_Human2.03145198
14GBX2_23144817_ChIP-Seq_PC3_Human2.01737311
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97519615
16EED_16625203_ChIP-ChIP_MESCs_Mouse1.94026969
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89811211
18BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84659675
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.83490823
20AR_21572438_ChIP-Seq_LNCaP_Human1.78955963
21FUS_26573619_Chip-Seq_HEK293_Human1.62792363
22P300_19829295_ChIP-Seq_ESCs_Human1.61156385
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58742122
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58258976
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52735467
26TDRD3_21172665_ChIP-Seq_MCF-7_Human1.52492632
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47262013
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46321038
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46212240
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.42625482
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.41564692
32TP53_22573176_ChIP-Seq_HFKS_Human1.40736454
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40449401
34MYC_18940864_ChIP-ChIP_HL60_Human1.38284100
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.37569139
36ZNF274_21170338_ChIP-Seq_K562_Hela1.34457658
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34377912
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33945811
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33252213
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.32877867
41TP53_20018659_ChIP-ChIP_R1E_Mouse1.32639464
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32589471
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32549926
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31336564
45CBP_20019798_ChIP-Seq_JUKART_Human1.31336564
46SOX2_19829295_ChIP-Seq_ESCs_Human1.31001605
47NANOG_19829295_ChIP-Seq_ESCs_Human1.31001605
48CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.30212789
49TAF15_26573619_Chip-Seq_HEK293_Human1.29855207
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28142706
51ERG_20517297_ChIP-Seq_VCAP_Human1.28024043
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25260381
53RNF2_27304074_Chip-Seq_NSC_Mouse1.23817497
54PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.23042632
55NANOG_20526341_ChIP-Seq_ESCs_Human1.22880080
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22052741
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22052741
58VDR_23849224_ChIP-Seq_CD4+_Human1.21887858
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19341767
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17966530
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.17389268
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16385991
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15747650
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15606876
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14047376
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11778094
67REST_21632747_ChIP-Seq_MESCs_Mouse1.09874939
68RXR_22108803_ChIP-Seq_LS180_Human1.08684199
69ERA_21632823_ChIP-Seq_H3396_Human1.07890671
70MYC_19829295_ChIP-Seq_ESCs_Human1.07049488
71BCAT_22108803_ChIP-Seq_LS180_Human1.06098160
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05867714
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04076773
74CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03263867
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01710497
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01508601
77KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01508601
78KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01508601
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00258190
80HTT_18923047_ChIP-ChIP_STHdh_Human0.99345468
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95483051
82FOXP3_21729870_ChIP-Seq_TREG_Human0.95210966
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94702576
84NANOG_16153702_ChIP-ChIP_HESCs_Human0.94496953
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94392256
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94278077
87ER_23166858_ChIP-Seq_MCF-7_Human0.93147636
88EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90543942
89SRF_21415370_ChIP-Seq_HL-1_Mouse0.90315706
90SMAD_19615063_ChIP-ChIP_OVARY_Human0.89524683
91IRF1_19129219_ChIP-ChIP_H3396_Human0.89498096
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88839483
93TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88729183
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88700299
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88565422
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.88198627
97AR_20517297_ChIP-Seq_VCAP_Human0.88133881
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86970230
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86970230
100EGR1_19032775_ChIP-ChIP_M12_Human0.86283277

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005646_abnormal_pituitary_gland3.96200063
2MP0009379_abnormal_foot_pigmentation3.31925395
3MP0009780_abnormal_chondrocyte_physiolo3.25557074
4MP0003283_abnormal_digestive_organ2.79323162
5MP0006072_abnormal_retinal_apoptosis2.70106563
6MP0003646_muscle_fatigue2.65367760
7MP0000372_irregular_coat_pigmentation2.62340739
8MP0004145_abnormal_muscle_electrophysio2.47641407
9MP0003938_abnormal_ear_development2.44459134
10MP0000049_abnormal_middle_ear2.34354638
11MP0006292_abnormal_olfactory_placode2.33309189
12MP0002095_abnormal_skin_pigmentation2.32348473
13MP0002102_abnormal_ear_morphology2.22044388
14MP0001968_abnormal_touch/_nociception2.11306912
15MP0002089_abnormal_postnatal_growth/wei2.05556074
16MP0008789_abnormal_olfactory_epithelium2.03254564
17MP0000747_muscle_weakness1.96252400
18MP0003123_paternal_imprinting1.93829991
19MP0002163_abnormal_gland_morphology1.92812102
20MP0005645_abnormal_hypothalamus_physiol1.90691909
21MP0001905_abnormal_dopamine_level1.82815243
22MP0004134_abnormal_chest_morphology1.80575199
23MP0000631_abnormal_neuroendocrine_gland1.74639887
24MP0000537_abnormal_urethra_morphology1.69747170
25MP0001485_abnormal_pinna_reflex1.65247126
26MP0005083_abnormal_biliary_tract1.64360591
27MP0002736_abnormal_nociception_after1.53980028
28MP0004885_abnormal_endolymph1.50508605
29MP0003806_abnormal_nucleotide_metabolis1.46180403
30MP0003880_abnormal_central_pattern1.44458176
31MP0005551_abnormal_eye_electrophysiolog1.41984107
32MP0003937_abnormal_limbs/digits/tail_de1.41286192
33MP0008877_abnormal_DNA_methylation1.40877628
34MP0002638_abnormal_pupillary_reflex1.39625672
35MP0000750_abnormal_muscle_regeneration1.38717170
36MP0002272_abnormal_nervous_system1.38290356
37MP0000613_abnormal_salivary_gland1.38170608
38MP0003787_abnormal_imprinting1.38126147
39MP0005171_absent_coat_pigmentation1.36104926
40MP0000566_synostosis1.32674200
41MP0000569_abnormal_digit_pigmentation1.32219094
42MP0000749_muscle_degeneration1.28126998
43MP0003011_delayed_dark_adaptation1.27745027
44MP0009745_abnormal_behavioral_response1.27698319
45MP0004142_abnormal_muscle_tone1.27451032
46MP0003315_abnormal_perineum_morphology1.25186899
47MP0003942_abnormal_urinary_system1.25120147
48MP0000759_abnormal_skeletal_muscle1.19340892
49MP0002108_abnormal_muscle_morphology1.18875126
50MP0002138_abnormal_hepatobiliary_system1.17473142
51MP0005075_abnormal_melanosome_morpholog1.15020553
52MP0008875_abnormal_xenobiotic_pharmacok1.14736846
53MP0009333_abnormal_splenocyte_physiolog1.12984025
54MP0003045_fibrosis1.12917040
55MP0005671_abnormal_response_to1.07889940
56MP0009250_abnormal_appendicular_skeleto1.04579920
57MP0002269_muscular_atrophy1.01556974
58MP0005499_abnormal_olfactory_system1.01417551
59MP0005394_taste/olfaction_phenotype1.01417551
60MP0005174_abnormal_tail_pigmentation1.01301292
61MP0000751_myopathy1.00389023
62MP0001486_abnormal_startle_reflex1.00291817
63MP0009053_abnormal_anal_canal0.99001301
64MP0005253_abnormal_eye_physiology0.98819712
65MP0005379_endocrine/exocrine_gland_phen0.98465187
66MP0004147_increased_porphyrin_level0.98402100
67MP0005670_abnormal_white_adipose0.96233983
68MP0000026_abnormal_inner_ear0.95398567
69MP0001963_abnormal_hearing_physiology0.93994170
70MP0002822_catalepsy0.92908106
71MP0005187_abnormal_penis_morphology0.92747899
72MP0002106_abnormal_muscle_physiology0.92460354
73MP0001879_abnormal_lymphatic_vessel0.91439224
74MP0002734_abnormal_mechanical_nocicepti0.90618345
75MP0002733_abnormal_thermal_nociception0.90355378
76MP0003119_abnormal_digestive_system0.89589238
77MP0005369_muscle_phenotype0.89287093
78MP0003959_abnormal_lean_body0.88269138
79MP0001986_abnormal_taste_sensitivity0.87714241
80MP0005423_abnormal_somatic_nervous0.85619683
81MP0002557_abnormal_social/conspecific_i0.82968607
82MP0001970_abnormal_pain_threshold0.82584779
83MP0000678_abnormal_parathyroid_gland0.82400076
84MP0002909_abnormal_adrenal_gland0.79638204
85MP0000733_abnormal_muscle_development0.78792870
86MP0002752_abnormal_somatic_nervous0.78651835
87MP0005620_abnormal_muscle_contractility0.77589972
88MP0008775_abnormal_heart_ventricle0.76372961
89MP0005389_reproductive_system_phenotype0.75340340
90MP0009046_muscle_twitch0.74282497
91MP0004742_abnormal_vestibular_system0.73569139
92MP0002064_seizures0.71156549
93MP0002160_abnormal_reproductive_system0.70906862
94MP0002751_abnormal_autonomic_nervous0.69961245
95MP0005377_hearing/vestibular/ear_phenot0.68223253
96MP0003878_abnormal_ear_physiology0.68223253
97MP0008872_abnormal_physiological_respon0.68085591
98MP0006276_abnormal_autonomic_nervous0.67762043
99MP0002184_abnormal_innervation0.67380642
100MP0002233_abnormal_nose_morphology0.67183131

Predicted human phenotypes

RankGene SetZ-score
1Stenosis of the external auditory canal (HP:0000402)4.13390165
2Palpebral edema (HP:0100540)3.95217132
3Pendular nystagmus (HP:0012043)3.87863476
4Severe visual impairment (HP:0001141)3.60642189
5Abnormality of macular pigmentation (HP:0008002)3.57847864
63-Methylglutaconic aciduria (HP:0003535)3.54132893
7Septo-optic dysplasia (HP:0100842)3.53467124
8Hepatocellular necrosis (HP:0001404)3.50398030
9Hyperglycinemia (HP:0002154)3.49823416
10Mitochondrial inheritance (HP:0001427)3.32318562
11Acute necrotizing encephalopathy (HP:0006965)3.27940087
12Absent phalangeal crease (HP:0006109)3.09636992
13Abnormal mitochondria in muscle tissue (HP:0008316)3.02590943
14Acute encephalopathy (HP:0006846)3.00245803
15Hamartoma of the eye (HP:0010568)2.92245530
16Abnormality of cells of the erythroid lineage (HP:0012130)2.84438442
17Progressive macrocephaly (HP:0004481)2.81688802
18Increased CSF lactate (HP:0002490)2.80136040
19Hepatic necrosis (HP:0002605)2.79119516
20Fibular aplasia (HP:0002990)2.75033752
21Abnormal number of erythroid precursors (HP:0012131)2.74232689
22Conjunctival hamartoma (HP:0100780)2.74045884
23Congenital stationary night blindness (HP:0007642)2.65610269
24Abnormality of the proximal phalanges of the hand (HP:0009834)2.63961426
25Abnormal finger flexion creases (HP:0006143)2.59017912
26Nemaline bodies (HP:0003798)2.57476749
27Abolished electroretinogram (ERG) (HP:0000550)2.57119406
28Increased corneal curvature (HP:0100692)2.55935435
29Keratoconus (HP:0000563)2.55935435
30Dicarboxylic aciduria (HP:0003215)2.55896793
31Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55896793
32Symphalangism affecting the phalanges of the hand (HP:0009773)2.54282729
33Abnormality of the phalanges of the 2nd finger (HP:0009541)2.51835804
34Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.48468424
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46139038
36Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45842909
37Absent septum pellucidum (HP:0001331)2.45729413
38Increased hepatocellular lipid droplets (HP:0006565)2.45231268
39Mask-like facies (HP:0000298)2.44423698
40Long nose (HP:0003189)2.44063347
41Increased intramyocellular lipid droplets (HP:0012240)2.42191998
42Hypoplasia of the uterus (HP:0000013)2.39439584
43Macroorchidism (HP:0000053)2.38876000
44Abnormality of the middle phalanges of the toes (HP:0010183)2.37499547
45Abnormality of the septum pellucidum (HP:0007375)2.36735024
46Hypoplasia of the ulna (HP:0003022)2.35274698
47Abnormality of the phalanges of the 5th finger (HP:0004213)2.34418013
48Lipid accumulation in hepatocytes (HP:0006561)2.31731481
49Pancreatic cysts (HP:0001737)2.30722176
50Large eyes (HP:0001090)2.28873790
51Broad hallux (HP:0010055)2.27590995
52Abnormality of the nasal septum (HP:0000419)2.26967674
53Abnormality of purine metabolism (HP:0004352)2.26857547
54Methylmalonic acidemia (HP:0002912)2.26845749
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.24387493
56Aplasia/hypoplasia of the uterus (HP:0008684)2.23185696
57Distal arthrogryposis (HP:0005684)2.20160508
58Renal Fanconi syndrome (HP:0001994)2.18033670
59Exercise-induced myalgia (HP:0003738)2.17804885
60Abnormal rod and cone electroretinograms (HP:0008323)2.16712307
61Pancreatic fibrosis (HP:0100732)2.14058913
62Abnormal umbilical cord blood vessels (HP:0011403)2.13905053
63Single umbilical artery (HP:0001195)2.13905053
64Abnormality of the fetal cardiovascular system (HP:0010948)2.13905053
65Forearm undergrowth (HP:0009821)2.12558753
66Hypoplasia of the radius (HP:0002984)2.11397397
67Methylmalonic aciduria (HP:0012120)2.10628228
68Goiter (HP:0000853)2.05901633
69Aplasia/Hypoplasia of the ulna (HP:0006495)2.03758988
70Decreased circulating renin level (HP:0003351)2.03552282
71Morphological abnormality of the middle ear (HP:0008609)2.03148503
72Muscle fiber inclusion bodies (HP:0100299)2.01621320
73Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.98706076
74Decreased central vision (HP:0007663)1.97324500
75Attenuation of retinal blood vessels (HP:0007843)1.93966672
76IgG deficiency (HP:0004315)1.93667572
77Abnormality of glycine metabolism (HP:0010895)1.93513073
78Abnormality of serine family amino acid metabolism (HP:0010894)1.93513073
79Cerebral edema (HP:0002181)1.93358220
80Increased muscle lipid content (HP:0009058)1.92629516
81Neoplasm of the heart (HP:0100544)1.91014098
82Optic disc pallor (HP:0000543)1.90920346
83Neoplasm of striated muscle (HP:0009728)1.89903598
84Down-sloping shoulders (HP:0200021)1.88761986
85Calcaneovalgus deformity (HP:0001848)1.88745037
86Aplasia/Hypoplasia of the spleen (HP:0010451)1.85377927
87Maternal diabetes (HP:0009800)1.84860916
88Agitation (HP:0000713)1.84424545
89Tented upper lip vermilion (HP:0010804)1.82702879
90Broad toe (HP:0001837)1.81801887
91Humeroradial synostosis (HP:0003041)1.81649476
92Synostosis involving the elbow (HP:0003938)1.81649476
93Deformed tarsal bones (HP:0008119)1.81615516
94Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81256133
95Optic nerve hypoplasia (HP:0000609)1.81117893
96Reticulocytopenia (HP:0001896)1.81110029
97Fused cervical vertebrae (HP:0002949)1.81054315
98Short 4th metacarpal (HP:0010044)1.80444307
99Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.80444307
100Ulnar deviation of the wrist (HP:0003049)1.79830830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.71907170
2TXK3.75482181
3VRK23.72920516
4KDR3.31940317
5TESK22.90840493
6MUSK2.43376504
7STK162.25752053
8LIMK12.22760634
9ADRBK22.22469635
10MAP3K122.11595615
11SCYL22.10440638
12PHKG22.03484549
13PHKG12.03484549
14TLK12.02446648
15TIE11.94345188
16NEK91.87438720
17BCKDK1.80683379
18NUAK11.79266445
19OBSCN1.70868841
20SIK21.68440793
21IRAK11.64436022
22IKBKE1.59328140
23TESK11.54980492
24EPHA41.52705649
25VRK11.46471528
26GRK71.35493414
27MAP3K101.29850114
28ZAK1.29526054
29PKN11.28150038
30AURKA1.28117941
31NTRK21.25602551
32GRK11.18592256
33SMG11.13470246
34MYLK1.12860011
35RPS6KA51.07780414
36CSNK1G21.04694170
37INSRR1.04415233
38TAF11.02185023
39DYRK20.96529782
40CASK0.96013438
41LRRK20.90663489
42DYRK1B0.90513415
43ILK0.88744959
44WNK10.85990834
45CAMKK20.85798252
46WNK40.85757728
47CAMK10.85753385
48PASK0.84627858
49ADRBK10.83221011
50CDK190.81774437
51RPS6KA40.80352595
52ERBB20.79104544
53ITK0.74638721
54MAPK130.70535610
55PAK30.69847341
56CSNK1G10.69422709
57PRKCQ0.66966223
58PDK20.66475278
59BUB10.64885791
60EPHB20.58385420
61BMPR1B0.57908030
62PRKCE0.57866616
63RPS6KA20.57837094
64FRK0.55885435
65RPS6KA60.55770529
66CSNK1G30.55568900
67MAP4K10.54504439
68ROCK10.53993901
69PRKACA0.53092158
70RPS6KL10.50714218
71RPS6KC10.50714218
72PTK60.50062741
73TNIK0.49585305
74PRKCG0.48643485
75CSNK1A10.48570001
76PLK20.48492037
77WNK30.47233024
78CSNK2A10.46889316
79IKBKB0.44445132
80KIT0.43091631
81OXSR10.42805139
82CAMK2G0.41320421
83PRKCA0.39944034
84PRKG10.39415696
85MARK20.39357356
86PRKACB0.38189915
87TEC0.37057882
88MAP3K90.36845614
89MINK10.33131293
90PINK10.32869984
91CSNK2A20.32649212
92AURKB0.32201154
93LYN0.32069816
94GRK60.31883458
95PIK3CA0.30980208
96MOS0.30711492
97JAK30.30573553
98MST40.30055689
99MAPK70.29113382
100PLK10.29034071

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.62707008
2Sulfur metabolism_Homo sapiens_hsa009204.62316560
3Oxidative phosphorylation_Homo sapiens_hsa001904.13404101
4Parkinsons disease_Homo sapiens_hsa050123.59681664
5Proteasome_Homo sapiens_hsa030503.53374376
6Alzheimers disease_Homo sapiens_hsa050102.57244041
7Cardiac muscle contraction_Homo sapiens_hsa042602.32017306
8Huntingtons disease_Homo sapiens_hsa050162.16623024
9Protein export_Homo sapiens_hsa030601.84508126
10Maturity onset diabetes of the young_Homo sapiens_hsa049501.83790180
11Retinol metabolism_Homo sapiens_hsa008301.77821427
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.76426827
13Phototransduction_Homo sapiens_hsa047441.75033783
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62840204
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52646291
16Morphine addiction_Homo sapiens_hsa050321.42109641
17RNA polymerase_Homo sapiens_hsa030201.41751414
18Tight junction_Homo sapiens_hsa045301.38138030
19Nicotine addiction_Homo sapiens_hsa050331.36448948
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34798493
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29434516
22Basal transcription factors_Homo sapiens_hsa030221.28107064
23Asthma_Homo sapiens_hsa053101.27130069
24Nitrogen metabolism_Homo sapiens_hsa009101.20413762
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.20042946
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19863399
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16050727
28Primary immunodeficiency_Homo sapiens_hsa053401.15534331
29Graft-versus-host disease_Homo sapiens_hsa053321.13323448
30RNA degradation_Homo sapiens_hsa030181.10973990
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.09447961
32Type I diabetes mellitus_Homo sapiens_hsa049401.07607403
33Peroxisome_Homo sapiens_hsa041461.06947581
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04640073
35Sulfur relay system_Homo sapiens_hsa041221.01036874
36Autoimmune thyroid disease_Homo sapiens_hsa053201.00445393
37Caffeine metabolism_Homo sapiens_hsa002320.97279966
38Allograft rejection_Homo sapiens_hsa053300.94437263
39Gastric acid secretion_Homo sapiens_hsa049710.94007983
40Hedgehog signaling pathway_Homo sapiens_hsa043400.93513903
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90368153
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89887234
43Chemical carcinogenesis_Homo sapiens_hsa052040.89482237
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89153487
45Circadian entrainment_Homo sapiens_hsa047130.88974471
46GABAergic synapse_Homo sapiens_hsa047270.87671058
47Rheumatoid arthritis_Homo sapiens_hsa053230.87657273
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85744815
49Salivary secretion_Homo sapiens_hsa049700.84828862
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81348541
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73649565
52Collecting duct acid secretion_Homo sapiens_hsa049660.73535762
53Insulin secretion_Homo sapiens_hsa049110.72696874
54Starch and sucrose metabolism_Homo sapiens_hsa005000.70502284
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70119516
56Taste transduction_Homo sapiens_hsa047420.69419262
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69373438
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69335732
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69323268
60Basal cell carcinoma_Homo sapiens_hsa052170.67568246
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65892233
62Purine metabolism_Homo sapiens_hsa002300.65427461
63Pentose phosphate pathway_Homo sapiens_hsa000300.64690036
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63216350
65Butanoate metabolism_Homo sapiens_hsa006500.62372228
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.62162752
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62035499
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61506868
69Systemic lupus erythematosus_Homo sapiens_hsa053220.60758445
70Homologous recombination_Homo sapiens_hsa034400.60441249
71Calcium signaling pathway_Homo sapiens_hsa040200.58550761
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57481356
73Spliceosome_Homo sapiens_hsa030400.56845426
74Propanoate metabolism_Homo sapiens_hsa006400.53789231
75Antigen processing and presentation_Homo sapiens_hsa046120.53649629
76Synaptic vesicle cycle_Homo sapiens_hsa047210.53556603
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.51383786
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50388314
79Glutathione metabolism_Homo sapiens_hsa004800.49860522
80Dopaminergic synapse_Homo sapiens_hsa047280.48963861
81Oxytocin signaling pathway_Homo sapiens_hsa049210.48101371
82Galactose metabolism_Homo sapiens_hsa000520.45129576
83Fanconi anemia pathway_Homo sapiens_hsa034600.44565496
84Alcoholism_Homo sapiens_hsa050340.44076545
85Olfactory transduction_Homo sapiens_hsa047400.41681246
86Malaria_Homo sapiens_hsa051440.41394973
87Vitamin digestion and absorption_Homo sapiens_hsa049770.40561911
88Regulation of autophagy_Homo sapiens_hsa041400.40449174
89RNA transport_Homo sapiens_hsa030130.39805377
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39717415
91Viral myocarditis_Homo sapiens_hsa054160.39534283
92Metabolic pathways_Homo sapiens_hsa011000.38429649
93Linoleic acid metabolism_Homo sapiens_hsa005910.38180439
94ABC transporters_Homo sapiens_hsa020100.36727983
95Cocaine addiction_Homo sapiens_hsa050300.36422663
96Cholinergic synapse_Homo sapiens_hsa047250.36306615
97Pyrimidine metabolism_Homo sapiens_hsa002400.35730064
98Wnt signaling pathway_Homo sapiens_hsa043100.35263553
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35000653
100Serotonergic synapse_Homo sapiens_hsa047260.33122698

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