ATP5G2P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)6.78201454
2negative regulation of cell killing (GO:0031342)6.15878807
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.15878807
4positive regulation of gamma-delta T cell activation (GO:0046645)6.14743372
5negative T cell selection (GO:0043383)5.06238037
6regulation of gamma-delta T cell differentiation (GO:0045586)5.04543373
7negative regulation of T cell mediated immunity (GO:0002710)5.00289557
8negative thymic T cell selection (GO:0045060)4.98561597
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.94037713
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.71855850
11regulation of gamma-delta T cell activation (GO:0046643)4.65545357
12positive regulation of granulocyte differentiation (GO:0030854)4.53949799
13cellular response to interleukin-15 (GO:0071350)4.36438315
14response to interleukin-15 (GO:0070672)4.31325383
15positive T cell selection (GO:0043368)4.29738123
16hepatocyte apoptotic process (GO:0097284)4.25786107
17negative regulation of lymphocyte mediated immunity (GO:0002707)4.21453234
18positive thymic T cell selection (GO:0045059)4.16235866
19T cell migration (GO:0072678)3.94694279
20microglial cell activation (GO:0001774)3.90439311
21regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.89553883
22regulation of memory T cell differentiation (GO:0043380)3.83926335
23regulation of T cell mediated cytotoxicity (GO:0001914)3.83257791
24B cell receptor signaling pathway (GO:0050853)3.79728798
25negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.74204360
26detection of molecule of bacterial origin (GO:0032490)3.70978337
27neutrophil mediated immunity (GO:0002446)3.64418517
28regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.58929363
29cellular extravasation (GO:0045123)3.53565527
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.53186923
31interferon-gamma production (GO:0032609)3.52689624
32regulation of regulatory T cell differentiation (GO:0045589)3.50312613
33negative regulation of adaptive immune response (GO:0002820)3.46488558
34negative regulation of interleukin-12 production (GO:0032695)3.45388672
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.44230975
36positive regulation by organism of defense response of other organism involved in symbiotic interact3.44230975
37modulation by symbiont of host immune response (GO:0052553)3.44230975
38positive regulation by symbiont of host defense response (GO:0052509)3.44230975
39modulation by symbiont of host defense response (GO:0052031)3.44230975
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.44230975
41activated T cell proliferation (GO:0050798)3.43616283
42myeloid leukocyte mediated immunity (GO:0002444)3.40431266
43phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.38116658
44negative regulation of B cell proliferation (GO:0030889)3.36205337
45negative regulation of leukocyte mediated immunity (GO:0002704)3.33591665
46T cell selection (GO:0045058)3.32559533
47regulation of B cell differentiation (GO:0045577)3.31707441
48positive regulation of T cell mediated cytotoxicity (GO:0001916)3.26260736
49thymic T cell selection (GO:0045061)3.24561693
50histone mRNA catabolic process (GO:0071044)3.22137169
51regulation of interleukin-12 biosynthetic process (GO:0045075)3.19009466
52neutrophil activation (GO:0042119)3.14828038
53positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.12942701
54mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.12942701
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.10135794
56mast cell activation (GO:0045576)3.09699605
57regulation of granulocyte differentiation (GO:0030852)3.07526377
58positive regulation of B cell differentiation (GO:0045579)3.07467680
59response to host immune response (GO:0052572)3.05907684
60response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.05907684
61negative regulation of NF-kappaB import into nucleus (GO:0042347)3.04776072
62natural killer cell activation involved in immune response (GO:0002323)3.04529269
63leukocyte aggregation (GO:0070486)3.04486676
64antigen processing and presentation of endogenous antigen (GO:0019883)3.03907153
65regulation of MHC class I biosynthetic process (GO:0045343)3.03484381
66dosage compensation (GO:0007549)2.99209210
67B cell proliferation (GO:0042100)2.98556365
68alpha-beta T cell differentiation (GO:0046632)2.96338859
69regulation of alpha-beta T cell proliferation (GO:0046640)2.95606239
70tolerance induction (GO:0002507)2.95578052
71mast cell degranulation (GO:0043303)2.95393916
72mast cell activation involved in immune response (GO:0002279)2.95393916
73macrophage activation (GO:0042116)2.95258789
74antigen receptor-mediated signaling pathway (GO:0050851)2.94426053
75positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.94039693
76negative regulation of B cell mediated immunity (GO:0002713)2.92605948
77negative regulation of immunoglobulin mediated immune response (GO:0002890)2.92605948
78necroptotic process (GO:0070266)2.91735947
79detection of external biotic stimulus (GO:0098581)2.91446162
80macrophage activation involved in immune response (GO:0002281)2.90780229
81regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.88633678
82myeloid cell activation involved in immune response (GO:0002275)2.87929633
83neutrophil activation involved in immune response (GO:0002283)2.87501744
84establishment of protein localization to Golgi (GO:0072600)2.87067894
85antigen processing and presentation via MHC class Ib (GO:0002475)2.86481096
86positive regulation of alpha-beta T cell proliferation (GO:0046641)2.85883427
87necrotic cell death (GO:0070265)2.85705591
88leukocyte degranulation (GO:0043299)2.85311367
89programmed necrotic cell death (GO:0097300)2.83598943
90protein targeting to Golgi (GO:0000042)2.83499520
91regulation of isotype switching to IgG isotypes (GO:0048302)2.82278681
92regulation of interferon-beta biosynthetic process (GO:0045357)2.81651985
93alpha-beta T cell activation (GO:0046631)2.80885433
94lymph node development (GO:0048535)2.80685763
95negative regulation of protein oligomerization (GO:0032460)2.80422897
96regulation of cell killing (GO:0031341)2.79390978
97histone H3-K36 demethylation (GO:0070544)2.79286551
98negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.77783732
99regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.76517319
100regulation of leukocyte mediated cytotoxicity (GO:0001910)2.75684505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.72736489
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.44391935
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.19057491
4RUNX_20019798_ChIP-Seq_JUKART_Human3.55349029
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.46966223
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.25031225
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.98632947
8MYB_26560356_Chip-Seq_TH2_Human2.96059381
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.90701187
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.75935230
11SCL_19346495_ChIP-Seq_HPC-7_Human2.71318154
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.53388875
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50077687
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.40137583
15MYB_26560356_Chip-Seq_TH1_Human2.39685128
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.37965189
17GATA3_27048872_Chip-Seq_THYMUS_Human2.28483899
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26661017
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.18851903
20SPI1_23547873_ChIP-Seq_NB4_Human2.06374544
21GATA3_26560356_Chip-Seq_TH2_Human2.05866496
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.01757165
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01226476
24VDR_24787735_ChIP-Seq_THP-1_Human1.92059819
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.80526039
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74813018
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.71546093
28RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.70923769
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69533895
30AR_21572438_ChIP-Seq_LNCaP_Human1.66992817
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64988248
32PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59617974
33SPI1_23127762_ChIP-Seq_K562_Human1.59531557
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58028727
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.55689560
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53583751
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.52896761
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52522083
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47858145
40MAF_26560356_Chip-Seq_TH1_Human1.46930459
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.46598687
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46161942
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45167194
44UTX_26944678_Chip-Seq_JUKART_Human1.42655391
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41961283
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41106986
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37923756
48NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.35860822
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35409585
50VDR_24763502_ChIP-Seq_THP-1_Human1.34355467
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33304368
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32290779
53PU_27001747_Chip-Seq_BMDM_Mouse1.31070185
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29491668
55GATA1_22025678_ChIP-Seq_K562_Human1.25565609
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24032850
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19326259
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19187236
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.19186900
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17783387
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.14722623
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14157212
63ER_23166858_ChIP-Seq_MCF-7_Human1.13008885
64GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11560479
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.09866784
66GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.07973524
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.06309508
68MAF_26560356_Chip-Seq_TH2_Human1.04976767
69IRF1_19129219_ChIP-ChIP_H3396_Human1.04939291
70SMRT_27268052_Chip-Seq_Bcells_Human1.04659561
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04318355
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.03505405
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03382621
74OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99008329
75CIITA_25753668_ChIP-Seq_RAJI_Human0.98123395
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95975066
77FOXO3_23340844_ChIP-Seq_DLD1_Human0.94517013
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93544293
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93480789
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91935603
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91912530
82GATA2_19941826_ChIP-Seq_K562_Human0.91087198
83POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90995803
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90876681
85SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90516251
86GATA3_26560356_Chip-Seq_TH1_Human0.90245015
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89752888
88RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88794762
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88589109
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87422212
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87205869
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87205869
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86789201
94TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.86506663
95STAT1_20625510_ChIP-Seq_HELA_Human0.86291736
96CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85053012
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84775170
98GATA1_19941826_ChIP-Seq_K562_Human0.84559296
99VDR_23849224_ChIP-Seq_CD4+_Human0.83668599
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.82511494

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.78368978
2MP0000569_abnormal_digit_pigmentation4.41918283
3MP0001835_abnormal_antigen_presentation3.46012783
4MP0005671_abnormal_response_to3.33200921
5MP0003763_abnormal_thymus_physiology3.16721642
6MP0008260_abnormal_autophagy3.10899766
7MP0001800_abnormal_humoral_immune3.06904217
8MP0003436_decreased_susceptibility_to2.80876439
9MP0003787_abnormal_imprinting2.74438899
10MP0005000_abnormal_immune_tolerance2.64238508
11MP0004381_abnormal_hair_follicle2.61806162
12MP0002723_abnormal_immune_serum2.47172987
13MP0001819_abnormal_immune_cell2.44780879
14MP0002420_abnormal_adaptive_immunity2.44243617
15MP0002452_abnormal_antigen_presenting2.41648466
16MP0002419_abnormal_innate_immunity2.39214540
17MP0000685_abnormal_immune_system2.24198456
18MP0003303_peritoneal_inflammation2.21536585
19MP0005025_abnormal_response_to2.18355971
20MP0003656_abnormal_erythrocyte_physiolo2.14336620
21MP0005075_abnormal_melanosome_morpholog2.08234512
22MP0002166_altered_tumor_susceptibility2.07712053
23MP0002398_abnormal_bone_marrow2.04336655
24MP0009785_altered_susceptibility_to1.98538393
25MP0000716_abnormal_immune_system1.91795020
26MP0005387_immune_system_phenotype1.90954908
27MP0001790_abnormal_immune_system1.90954908
28MP0005174_abnormal_tail_pigmentation1.89551764
29MP0008877_abnormal_DNA_methylation1.83835607
30MP0003828_pulmonary_edema1.82432561
31MP0003866_abnormal_defecation1.74557725
32MP0005464_abnormal_platelet_physiology1.71490765
33MP0000689_abnormal_spleen_morphology1.71054956
34MP0006082_CNS_inflammation1.70984797
35MP0000703_abnormal_thymus_morphology1.69182923
36MP0002722_abnormal_immune_system1.66525249
37MP0002148_abnormal_hypersensitivity_rea1.66424245
38MP0002405_respiratory_system_inflammati1.66189966
39MP0005310_abnormal_salivary_gland1.58377468
40MP0000015_abnormal_ear_pigmentation1.57614016
41MP0004947_skin_inflammation1.56379993
42MP0003172_abnormal_lysosome_physiology1.54530580
43MP0002138_abnormal_hepatobiliary_system1.53269555
44MP0003300_gastrointestinal_ulcer1.51990103
45MP0002429_abnormal_blood_cell1.51614537
46MP0001533_abnormal_skeleton_physiology1.49968063
47MP0001845_abnormal_inflammatory_respons1.49204545
48MP0002396_abnormal_hematopoietic_system1.47649735
49MP0004883_abnormal_blood_vessel1.44328710
50MP0002006_tumorigenesis1.37864016
51MP0001851_eye_inflammation1.37432924
52MP0000465_gastrointestinal_hemorrhage1.31075147
53MP0009764_decreased_sensitivity_to1.24948707
54MP0001986_abnormal_taste_sensitivity1.18285393
55MP0001853_heart_inflammation1.15475242
56MP0010155_abnormal_intestine_physiology1.13619130
57MP0002332_abnormal_exercise_endurance1.13120671
58MP0004484_altered_response_of1.11548373
59MP0005167_abnormal_blood-brain_barrier1.05493796
60MP0008469_abnormal_protein_level1.00186423
61MP0009333_abnormal_splenocyte_physiolog0.99110513
62MP0002876_abnormal_thyroid_physiology0.97957933
63MP0005164_abnormal_response_to0.97954387
64MP0001545_abnormal_hematopoietic_system0.93657665
65MP0005397_hematopoietic_system_phenotyp0.93657665
66MP0002009_preneoplasia0.92815307
67MP0003690_abnormal_glial_cell0.91288929
68MP0002928_abnormal_bile_duct0.87825136
69MP0004264_abnormal_extraembryonic_tissu0.87193959
70MP0002998_abnormal_bone_remodeling0.86486998
71MP0006054_spinal_hemorrhage0.84043920
72MP0000858_altered_metastatic_potential0.83520081
73MP0000371_diluted_coat_color0.83376010
74MP0009763_increased_sensitivity_to0.77322136
75MP0004808_abnormal_hematopoietic_stem0.76481478
76MP0000427_abnormal_hair_cycle0.76022997
77MP0009278_abnormal_bone_marrow0.75846288
78MP0000604_amyloidosis0.74921811
79MP0005451_abnormal_body_composition0.74331663
80MP0004147_increased_porphyrin_level0.74217026
81MP0000249_abnormal_blood_vessel0.73941258
82MP0002277_abnormal_respiratory_mucosa0.73309210
83MP0003646_muscle_fatigue0.73252989
84MP0003195_calcinosis0.72899495
85MP0008057_abnormal_DNA_replication0.71094417
86MP0009765_abnormal_xenobiotic_induced0.68120677
87MP0003221_abnormal_cardiomyocyte_apopto0.67249676
88MP0002019_abnormal_tumor_incidence0.67210974
89MP0004130_abnormal_muscle_cell0.66241775
90MP0003183_abnormal_peptide_metabolism0.65401882
91MP0005376_homeostasis/metabolism_phenot0.64159290
92MP0003121_genomic_imprinting0.63754761
93MP0002136_abnormal_kidney_physiology0.63283248
94MP0005266_abnormal_metabolism0.62427076
95MP0002095_abnormal_skin_pigmentation0.61365675
96MP0002933_joint_inflammation0.59949857
97MP0002127_abnormal_cardiovascular_syste0.57889334
98MP0003091_abnormal_cell_migration0.52292094
99MP0005408_hypopigmentation0.51805938
100MP0002132_abnormal_respiratory_system0.49823588

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.88137365
2Abnormality of T cell number (HP:0011839)5.62456617
3Retrobulbar optic neuritis (HP:0100654)5.26218352
4Optic neuritis (HP:0100653)5.26218352
5Prostate neoplasm (HP:0100787)5.03899525
6Recurrent bacterial skin infections (HP:0005406)5.02577032
7Stomach cancer (HP:0012126)4.94901457
8Myositis (HP:0100614)4.78316633
9Orchitis (HP:0100796)4.69519322
10Stomatitis (HP:0010280)4.51674933
11Elevated erythrocyte sedimentation rate (HP:0003565)4.36427375
12Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.34485142
13Recurrent abscess formation (HP:0002722)4.29262963
14Abnormality of T cells (HP:0002843)4.15083765
15Abnormal delayed hypersensitivity skin test (HP:0002963)4.12969244
16Recurrent fungal infections (HP:0002841)4.01828334
17Abnormality of the prostate (HP:0008775)3.93427398
18Gastrointestinal infarctions (HP:0005244)3.66950067
19IgG deficiency (HP:0004315)3.64230869
20Keratoconjunctivitis sicca (HP:0001097)3.62268122
21Eczematoid dermatitis (HP:0000976)3.60621242
22Recurrent cutaneous fungal infections (HP:0011370)3.49778491
23Chronic mucocutaneous candidiasis (HP:0002728)3.49778491
24Recurrent skin infections (HP:0001581)3.44718172
25Keratoconjunctivitis (HP:0001096)3.43932309
26Leukocytosis (HP:0001974)3.29200035
27Vasculitis (HP:0002633)3.25675362
28Encephalitis (HP:0002383)3.25381231
29Thyroiditis (HP:0100646)3.25254696
30Abnormality of eosinophils (HP:0001879)3.16006787
31Autoimmune thrombocytopenia (HP:0001973)3.12604511
32IgM deficiency (HP:0002850)3.11277288
33Abnormality of T cell physiology (HP:0011840)3.08022964
34Meningitis (HP:0001287)3.05784496
35Panhypogammaglobulinemia (HP:0003139)3.04355731
36Recurrent viral infections (HP:0004429)3.01983782
37Arterial thrombosis (HP:0004420)2.97815858
38Severe combined immunodeficiency (HP:0004430)2.95412967
39Eosinophilia (HP:0001880)2.91829366
40Hemoptysis (HP:0002105)2.90428781
41Autoimmune hemolytic anemia (HP:0001890)2.87722619
42Pulmonary infiltrates (HP:0002113)2.81773012
43Spontaneous hematomas (HP:0007420)2.74020115
44Granulocytopenia (HP:0001913)2.72837055
45Mediastinal lymphadenopathy (HP:0100721)2.72176755
46Gingival bleeding (HP:0000225)2.66023790
47Inflammation of the large intestine (HP:0002037)2.65497309
48Pustule (HP:0200039)2.64633667
49Abnormality of male internal genitalia (HP:0000022)2.63642746
50Pulmonary embolism (HP:0002204)2.62384345
51Chest pain (HP:0100749)2.55077211
52Recurrent bronchitis (HP:0002837)2.50695597
53Slow saccadic eye movements (HP:0000514)2.50374687
54Gingivitis (HP:0000230)2.50153458
55Recurrent gram-negative bacterial infections (HP:0005420)2.45477499
56Peritonitis (HP:0002586)2.44580065
57Gastrointestinal inflammation (HP:0004386)2.41305578
58Gangrene (HP:0100758)2.41219006
59IgA deficiency (HP:0002720)2.40113332
60Colitis (HP:0002583)2.39777537
61Acute hepatic failure (HP:0006554)2.34547058
62Periodontitis (HP:0000704)2.29854048
63Postural instability (HP:0002172)2.29530692
64Epistaxis (HP:0000421)2.18266459
65Urticaria (HP:0001025)2.15432547
66Abnormality of the columella (HP:0009929)2.15291465
67Amyotrophic lateral sclerosis (HP:0007354)2.15257980
68Anorexia (HP:0002039)2.14141860
69Prolonged bleeding time (HP:0003010)2.13367931
70Viral hepatitis (HP:0006562)2.09274842
71Combined immunodeficiency (HP:0005387)2.08712481
72Abnormality of B cell number (HP:0010975)2.07072307
73Agammaglobulinemia (HP:0004432)2.06424761
74Increased IgM level (HP:0003496)2.05878526
75Neoplasm of the tracheobronchial system (HP:0100552)2.05851713
76Verrucae (HP:0200043)2.01825560
77Papilloma (HP:0012740)2.01825560
78Obstructive lung disease (HP:0006536)2.00911778
79Chronic obstructive pulmonary disease (HP:0006510)2.00911778
80Hypoplasia of the thymus (HP:0000778)1.99651658
81Glomerulopathy (HP:0100820)1.98671979
82Genetic anticipation (HP:0003743)1.97056459
83Abnormality of the pleura (HP:0002103)1.96905646
84Lymphopenia (HP:0001888)1.95108582
85Abnormality of macrophages (HP:0004311)1.95097118
86Alveolar cell carcinoma (HP:0006519)1.92515421
87Abnormality of the fingertips (HP:0001211)1.91249270
88Abnormality of cells of the lymphoid lineage (HP:0012140)1.90351462
89Hematochezia (HP:0002573)1.90310477
90Metaphyseal dysplasia (HP:0100255)1.90106839
91Aplastic anemia (HP:0001915)1.85280057
92Neurodegeneration (HP:0002180)1.84058361
93Albinism (HP:0001022)1.83966403
94Ocular albinism (HP:0001107)1.83787076
95Facial diplegia (HP:0001349)1.83386510
96Conjunctival telangiectasia (HP:0000524)1.80825902
97Subacute progressive viral hepatitis (HP:0006572)1.79411573
98Fatigue (HP:0012378)1.76810192
99Abnormality of the vasculature of the conjunctiva (HP:0008054)1.74309003
100Pulmonary fibrosis (HP:0002206)1.73737016

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.93581723
2RIPK43.51490855
3TXK3.38083238
4FES2.94861174
5GRK62.82113789
6MAP4K12.69332587
7IKBKE2.64857970
8BLK2.50594859
9JAK32.36407296
10SYK2.32136685
11MAP3K142.31413396
12FRK2.29353816
13CSK2.02119125
14BTK2.01394410
15PIK3CG1.85448231
16ITK1.81660976
17JAK11.79468387
18IRAK41.78281181
19MAP2K21.77747403
20PTK2B1.77106090
21TEC1.69502007
22BMPR21.65373577
23TYK21.44138318
24WNK11.42853006
25FGR1.42381548
26LYN1.38940486
27HCK1.36324652
28TNK21.34507855
29SGK21.33059953
30LCK1.31868606
31IKBKB1.31012791
32TRPM71.30091152
33TLK11.29876905
34MAP2K31.26512167
35CDK121.26183912
36STK41.23150710
37MARK31.20344103
38PIK3CA1.12503472
39PIM11.11548065
40IRAK11.11449097
41ZAP701.09957022
42FGFR31.07627963
43TBK11.02626565
44DYRK31.02391117
45JAK21.00276808
46GRK50.99262056
47KIT0.90158555
48ERBB20.89600888
49SRPK10.87945780
50CSF1R0.85544841
51PLK20.84950857
52CHUK0.83265820
53SGK30.79789876
54MAP3K20.76333864
55MAP3K130.75719160
56IRAK20.74006491
57DYRK1A0.73851847
58NLK0.73656741
59SGK4940.71945498
60SGK2230.71945498
61BRD40.71813044
62YES10.69254199
63EGFR0.67710278
64PRKCQ0.64897141
65MARK20.63611442
66STK100.63172760
67MAP3K60.61873593
68PDK10.58941312
69MAPK70.57239219
70NUAK10.55979038
71PRKAA20.55607407
72LRRK20.53900971
73STK380.53426947
74MATK0.52320702
75MAP4K20.51802541
76HIPK20.49817447
77TESK20.49808022
78SGK10.49203845
79CAMKK20.48731055
80RPS6KA40.47305586
81EPHA30.47128307
82PAK30.46560933
83ZAK0.45475908
84NEK60.44797757
85CDC42BPA0.44130859
86ADRBK10.43288414
87CAMK40.41310886
88ERBB30.40704005
89SIK20.40062902
90FYN0.39769622
91ABL10.39610988
92IGF1R0.39087408
93SIK30.39031180
94ACVR1B0.38177168
95MAP3K50.36184754
96RPS6KA50.35335175
97MAPK110.34332340
98STK110.33884799
99MAPKAPK20.33362225
100MAP3K10.32933924

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.47738559
2Leishmaniasis_Homo sapiens_hsa051403.04333323
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.58335548
4Allograft rejection_Homo sapiens_hsa053302.51088980
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.44834730
6Autoimmune thyroid disease_Homo sapiens_hsa053202.43468798
7B cell receptor signaling pathway_Homo sapiens_hsa046622.34114581
8Osteoclast differentiation_Homo sapiens_hsa043802.28851383
9Graft-versus-host disease_Homo sapiens_hsa053322.28208309
10T cell receptor signaling pathway_Homo sapiens_hsa046602.22010686
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.17785664
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.15402549
13Hematopoietic cell lineage_Homo sapiens_hsa046402.14009828
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.13120159
15Asthma_Homo sapiens_hsa053102.04921893
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.98286000
17Staphylococcus aureus infection_Homo sapiens_hsa051501.86012205
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.80884999
19Measles_Homo sapiens_hsa051621.70659455
20Tuberculosis_Homo sapiens_hsa051521.67202946
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58022540
22Type I diabetes mellitus_Homo sapiens_hsa049401.54881040
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51926023
24Herpes simplex infection_Homo sapiens_hsa051681.51273703
25Platelet activation_Homo sapiens_hsa046111.50493263
26Non-small cell lung cancer_Homo sapiens_hsa052231.48901308
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46812872
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45020100
29TNF signaling pathway_Homo sapiens_hsa046681.40259981
30Malaria_Homo sapiens_hsa051441.39227559
31Influenza A_Homo sapiens_hsa051641.35302233
32Toxoplasmosis_Homo sapiens_hsa051451.33783705
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30116350
34Antigen processing and presentation_Homo sapiens_hsa046121.28053619
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26691699
36Hepatitis B_Homo sapiens_hsa051611.19551479
37Chemokine signaling pathway_Homo sapiens_hsa040621.19531074
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17926483
39Acute myeloid leukemia_Homo sapiens_hsa052211.16529086
40Legionellosis_Homo sapiens_hsa051341.14744775
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.10175731
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04905994
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02323609
44Circadian rhythm_Homo sapiens_hsa047101.01014796
45Dorso-ventral axis formation_Homo sapiens_hsa043200.98404481
46FoxO signaling pathway_Homo sapiens_hsa040680.94779461
47Viral myocarditis_Homo sapiens_hsa054160.93247294
48Prolactin signaling pathway_Homo sapiens_hsa049170.93240013
49Apoptosis_Homo sapiens_hsa042100.92143764
50Hepatitis C_Homo sapiens_hsa051600.84082785
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83532129
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82139503
53Inositol phosphate metabolism_Homo sapiens_hsa005620.77704855
54Butanoate metabolism_Homo sapiens_hsa006500.74009102
55African trypanosomiasis_Homo sapiens_hsa051430.72224961
56Pancreatic cancer_Homo sapiens_hsa052120.62414706
57Pertussis_Homo sapiens_hsa051330.62115617
58Lysine degradation_Homo sapiens_hsa003100.60658674
59Rheumatoid arthritis_Homo sapiens_hsa053230.60145142
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59692468
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.58222308
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57522985
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56096892
64Insulin resistance_Homo sapiens_hsa049310.54460898
65Renal cell carcinoma_Homo sapiens_hsa052110.54154685
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53427736
67Glycerolipid metabolism_Homo sapiens_hsa005610.51496702
68Regulation of autophagy_Homo sapiens_hsa041400.50966476
69VEGF signaling pathway_Homo sapiens_hsa043700.50780780
70Linoleic acid metabolism_Homo sapiens_hsa005910.50369522
71Phagosome_Homo sapiens_hsa041450.50224534
72Cholinergic synapse_Homo sapiens_hsa047250.49628266
73Ether lipid metabolism_Homo sapiens_hsa005650.49596491
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.47663898
75Arachidonic acid metabolism_Homo sapiens_hsa005900.46859087
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46471135
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46315310
78Shigellosis_Homo sapiens_hsa051310.46246692
79Chronic myeloid leukemia_Homo sapiens_hsa052200.46196421
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45899916
81Renin secretion_Homo sapiens_hsa049240.45636241
82Epstein-Barr virus infection_Homo sapiens_hsa051690.45410283
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44536610
84Viral carcinogenesis_Homo sapiens_hsa052030.43363782
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.39928973
86HIF-1 signaling pathway_Homo sapiens_hsa040660.39889751
87mTOR signaling pathway_Homo sapiens_hsa041500.39213994
88Endometrial cancer_Homo sapiens_hsa052130.38693615
89Type II diabetes mellitus_Homo sapiens_hsa049300.38265139
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38163819
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.38057684
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37743015
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36828982
94Systemic lupus erythematosus_Homo sapiens_hsa053220.36609285
95Choline metabolism in cancer_Homo sapiens_hsa052310.36435523
96Oxytocin signaling pathway_Homo sapiens_hsa049210.34214705
97ABC transporters_Homo sapiens_hsa020100.34146137
98HTLV-I infection_Homo sapiens_hsa051660.33819140
99Phototransduction_Homo sapiens_hsa047440.32525513
100Taste transduction_Homo sapiens_hsa047420.31324500

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