ATP5G3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding different proteins have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* energy coupled proton transport, down electrochemical gradient (GO:0015985)9.11022258
2* ATP synthesis coupled proton transport (GO:0015986)9.11022258
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.17729476
4respiratory electron transport chain (GO:0022904)8.04108309
5electron transport chain (GO:0022900)7.84116199
6tricarboxylic acid cycle (GO:0006099)6.26521599
7oxidative phosphorylation (GO:0006119)6.01209495
8* ATP biosynthetic process (GO:0006754)5.32567933
9sarcomere organization (GO:0045214)4.98725093
10proteasome assembly (GO:0043248)4.87527585
11viral transcription (GO:0019083)4.79280657
12negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.62777781
13translational termination (GO:0006415)4.62590171
14cardiac myofibril assembly (GO:0055003)4.57142225
15* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.56795944
16NADH metabolic process (GO:0006734)4.55102315
17* purine nucleoside triphosphate biosynthetic process (GO:0009145)4.52861971
18succinate metabolic process (GO:0006105)4.51138225
19inner mitochondrial membrane organization (GO:0007007)4.47213241
20ribosomal small subunit biogenesis (GO:0042274)4.42639594
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.39031349
22* hydrogen ion transmembrane transport (GO:1902600)4.38431396
23cellular ketone body metabolic process (GO:0046950)4.37053635
24cotranslational protein targeting to membrane (GO:0006613)4.32661338
25ribosomal large subunit biogenesis (GO:0042273)4.32448179
26protein targeting to ER (GO:0045047)4.27650054
27ribosomal small subunit assembly (GO:0000028)4.21230010
28muscle filament sliding (GO:0030049)4.18277742
29actin-myosin filament sliding (GO:0033275)4.18277742
30establishment of protein localization to endoplasmic reticulum (GO:0072599)4.15445143
31positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.14908112
32translational elongation (GO:0006414)4.10465951
33regulation of acyl-CoA biosynthetic process (GO:0050812)4.09748163
34maturation of SSU-rRNA (GO:0030490)4.09137408
35protein localization to endoplasmic reticulum (GO:0070972)4.06133187
36negative regulation of potassium ion transmembrane transport (GO:1901380)4.04863598
37* ribonucleoside triphosphate biosynthetic process (GO:0009201)4.03182423
38protein targeting to mitochondrion (GO:0006626)4.01514237
39regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.01246861
40regulation of mitochondrial translation (GO:0070129)3.99962839
41cardiac muscle contraction (GO:0060048)3.98776709
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.97094545
43myofibril assembly (GO:0030239)3.96208197
44regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.95383571
45regulation of coenzyme metabolic process (GO:0051196)3.91695080
46regulation of cofactor metabolic process (GO:0051193)3.91695080
47lysine catabolic process (GO:0006554)3.87809662
48lysine metabolic process (GO:0006553)3.87809662
49regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.86899691
50translation (GO:0006412)3.84575340
51ketone body metabolic process (GO:1902224)3.81537801
52oxaloacetate metabolic process (GO:0006107)3.80779534
53translational initiation (GO:0006413)3.79522894
54carnitine shuttle (GO:0006853)3.77878085
55ventricular cardiac muscle cell action potential (GO:0086005)3.74645657
56establishment of protein localization to mitochondrial membrane (GO:0090151)3.72918792
57* proton transport (GO:0015992)3.68993379
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.67861610
59establishment of protein localization to mitochondrion (GO:0072655)3.65932107
60* hydrogen transport (GO:0006818)3.65705057
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.65406437
62regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.63819243
63protein localization to mitochondrion (GO:0070585)3.63352788
64anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.63222046
65deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.63046842
66aspartate family amino acid catabolic process (GO:0009068)3.62635061
67regulation of cellular amino acid metabolic process (GO:0006521)3.62489066
682-oxoglutarate metabolic process (GO:0006103)3.61927359
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.61865064
70negative regulation of ligase activity (GO:0051352)3.61865064
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.61505949
72mitochondrial respiratory chain complex I assembly (GO:0032981)3.61505949
73NADH dehydrogenase complex assembly (GO:0010257)3.61505949
74cellular protein complex disassembly (GO:0043624)3.60651856
75cardiac muscle cell development (GO:0055013)3.60507232
76aerobic respiration (GO:0009060)3.59412230
77ribonucleoprotein complex biogenesis (GO:0022613)3.58628146
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.55291607
79protein complex biogenesis (GO:0070271)3.54712782
80heart contraction (GO:0060047)3.54303488
81heart process (GO:0003015)3.54303488
82viral life cycle (GO:0019058)3.53504216
83regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.53128272
84heart trabecula formation (GO:0060347)3.50145331
85glyoxylate metabolic process (GO:0046487)3.49328362
86chaperone-mediated protein transport (GO:0072321)3.48699318
87fatty acid transmembrane transport (GO:1902001)3.46975524
88termination of RNA polymerase III transcription (GO:0006386)3.46734518
89transcription elongation from RNA polymerase III promoter (GO:0006385)3.46734518
90* nucleoside triphosphate biosynthetic process (GO:0009142)3.44862555
91cellular component biogenesis (GO:0044085)3.44845248
92actin-mediated cell contraction (GO:0070252)3.43708457
93cardiac muscle tissue morphogenesis (GO:0055008)3.43041127
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.42876526
95CENP-A containing nucleosome assembly (GO:0034080)3.42188832
96bundle of His cell to Purkinje myocyte communication (GO:0086069)3.41606201
97generation of precursor metabolites and energy (GO:0006091)3.41296845
98DNA replication checkpoint (GO:0000076)3.40617405
99protein deneddylation (GO:0000338)3.38281914
100nucleobase-containing small molecule interconversion (GO:0015949)3.36130937
101mitochondrial respiratory chain complex assembly (GO:0033108)3.35762975
102regulation of actin filament-based movement (GO:1903115)3.34494675
103DNA strand elongation involved in DNA replication (GO:0006271)3.34106458
104formation of translation preinitiation complex (GO:0001731)3.33778831
105chromatin remodeling at centromere (GO:0031055)3.32821750
106nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32794303
107regulation of relaxation of muscle (GO:1901077)3.30958400
108cardiac cell development (GO:0055006)3.30421037
109regulation of cell communication by electrical coupling (GO:0010649)3.30024311
110* purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.29289783
111* purine nucleoside monophosphate biosynthetic process (GO:0009127)3.29289783
112regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.26130375
113protein neddylation (GO:0045116)3.25711378
114cullin deneddylation (GO:0010388)3.25578783
115positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.25385267
116telomere maintenance via semi-conservative replication (GO:0032201)3.23735089
117fatty acid beta-oxidation (GO:0006635)3.22650272
118IMP biosynthetic process (GO:0006188)3.22138748
119short-chain fatty acid metabolic process (GO:0046459)3.21184235
120signal transduction involved in DNA damage checkpoint (GO:0072422)3.21134596
121signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21134596
122DNA strand elongation (GO:0022616)3.21127980
123regulation of cellular respiration (GO:0043457)3.20676725
124cellular respiration (GO:0045333)3.20364713
125regulation of oxidative phosphorylation (GO:0002082)3.18507253
126DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.18220836
127sarcoplasmic reticulum calcium ion transport (GO:0070296)3.17323421
128pseudouridine synthesis (GO:0001522)3.16764449
129spliceosomal snRNP assembly (GO:0000387)3.16402924
130ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.16203894
131signal transduction involved in cell cycle checkpoint (GO:0072395)3.15049568
132branched-chain amino acid catabolic process (GO:0009083)3.14773490
133mitochondrial transport (GO:0006839)3.14688377
134striated muscle contraction (GO:0006941)3.13391723
135intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.12032657
136signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.12032657
137positive regulation of ligase activity (GO:0051351)3.11304642
138acetyl-CoA metabolic process (GO:0006084)3.11144257
139muscle tissue morphogenesis (GO:0060415)3.10584626
140signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.10475523
141signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.10475523
142signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.10475523
143purine nucleobase biosynthetic process (GO:0009113)3.10153572
144cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.07542025
145ribosome biogenesis (GO:0042254)3.07278433
146quinone biosynthetic process (GO:1901663)3.05727950
147ubiquinone biosynthetic process (GO:0006744)3.05727950
148regulation of sarcomere organization (GO:0060297)3.05430509
149establishment of integrated proviral latency (GO:0075713)3.04136923
150rRNA processing (GO:0006364)3.03038526
151protein complex disassembly (GO:0043241)3.02384149
152viral mRNA export from host cell nucleus (GO:0046784)3.02073529
153cell communication involved in cardiac conduction (GO:0086065)3.01006317
154regulation of the force of heart contraction (GO:0002026)3.00797014
155negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.00547263
156regulation of ubiquitin-protein transferase activity (GO:0051438)2.99961061
157pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.99671650
158cardiac muscle hypertrophy (GO:0003300)2.99318462
159regulation of sulfur metabolic process (GO:0042762)2.99054799
160adult heart development (GO:0007512)2.98073084
161macromolecular complex disassembly (GO:0032984)2.96336884
162rRNA modification (GO:0000154)2.95394760
163fatty acid oxidation (GO:0019395)2.95235444
164fatty acid catabolic process (GO:0009062)2.94053195
165regulation of membrane repolarization (GO:0060306)2.94020100
166L-phenylalanine metabolic process (GO:0006558)2.92534899
167erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.92534899
168actomyosin structure organization (GO:0031032)2.90550459
169regulation of skeletal muscle contraction (GO:0014819)2.89965717
170IMP metabolic process (GO:0046040)2.89636059
171lipid oxidation (GO:0034440)2.89331524
172regulation of ligase activity (GO:0051340)2.89173997
173mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.0580499

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.01339219
2* ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.54549277
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.27928574
4E2F7_22180533_ChIP-Seq_HELA_Human4.64030454
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.46125397
6MYC_18358816_ChIP-ChIP_MESCs_Mouse3.33467482
7* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.32629165
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.98181943
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.91010231
10* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90866610
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88492723
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.61037159
13EZH2_22144423_ChIP-Seq_EOC_Human2.59138614
14XRN2_22483619_ChIP-Seq_HELA_Human2.53703795
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42017506
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.34253716
17EP300_21415370_ChIP-Seq_HL-1_Mouse2.33703357
18* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.24633829
19ZNF263_19887448_ChIP-Seq_K562_Human2.23904250
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21977269
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19503874
22LXR_22158963_ChIP-Seq_LIVER_Mouse2.19454327
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.18993160
24TTF2_22483619_ChIP-Seq_HELA_Human2.17781984
25* FOXP3_21729870_ChIP-Seq_TREG_Human2.16726184
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.16311242
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.09950062
28VDR_23849224_ChIP-Seq_CD4+_Human2.08564856
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00839200
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00150293
31ELK1_19687146_ChIP-ChIP_HELA_Human1.99435883
32VDR_22108803_ChIP-Seq_LS180_Human1.97043426
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90383573
34* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.86934780
35GABP_19822575_ChIP-Seq_HepG2_Human1.86345917
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86264424
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85867172
38AR_21909140_ChIP-Seq_LNCAP_Human1.80262031
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78132406
40CLOCK_20551151_ChIP-Seq_293T_Human1.70809586
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.69703262
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64745560
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63683634
44* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63119295
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58106109
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57354987
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.57110435
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57086735
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56378279
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55213291
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52042285
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50440708
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50435321
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47692156
55* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47439075
56TBX20_22080862_ChIP-Seq_HEART_Mouse1.42729994
57TBX20_22328084_ChIP-Seq_HEART_Mouse1.42729994
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42602212
59ZNF274_21170338_ChIP-Seq_K562_Hela1.40547715
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39693796
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.38077728
62GABP_17652178_ChIP-ChIP_JURKAT_Human1.37860270
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.34222493
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33820090
65MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.32917629
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32384436
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29642854
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25326234
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.25297643
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.25199863
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.25196936
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23911587
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23761821
74HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23559639
75PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.22847335
76EST1_17652178_ChIP-ChIP_JURKAT_Human1.20664363
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20104025
78JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18638863
79RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18346435
80EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18346435
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.18324678
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17452733
83JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16052039
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15721490
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13162537
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13107082
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12796768
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12756446
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12328263
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12323116
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11986866
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10965389
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09671171
94MYC_18940864_ChIP-ChIP_HL60_Human1.08703806
95SRF_21415370_ChIP-Seq_HL-1_Mouse1.08419236
96* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08123313
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07650515
98SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06175537
99* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05896856
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04178248
101TAF15_26573619_Chip-Seq_HEK293_Human1.02375795
102KDM5A_27292631_Chip-Seq_BREAST_Human1.01473852
103ELK1_22589737_ChIP-Seq_MCF10A_Human1.00349016
104GATA4_21415370_ChIP-Seq_HL-1_Mouse1.00052345
105* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99815923
106BCAT_22108803_ChIP-Seq_LS180_Human0.99492998
107EZH2_27294783_Chip-Seq_ESCs_Mouse0.98628244
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98585775
109EED_16625203_ChIP-ChIP_MESCs_Mouse0.98174709
110SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97756957
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97515576
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96416987
113EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94604579
114ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94461511
115* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94410876
116FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93753833
117YY1_21170310_ChIP-Seq_MESCs_Mouse0.93226236
118ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92463288
119DCP1A_22483619_ChIP-Seq_HELA_Human0.91478854
120SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91101394
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90854982
122CTCF_27219007_Chip-Seq_Bcells_Human0.90848648
123SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90204640
124AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89860149
125MYC_18555785_ChIP-Seq_MESCs_Mouse0.88929083
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88681106
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86731665
128NANOG_16153702_ChIP-ChIP_HESCs_Human0.86587494
129CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86567870
130PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85683051
131SOX17_20123909_ChIP-Seq_XEN_Mouse0.85412740
132SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85192811
133TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84556059
134CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83824983
135OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83519881
136YY1_22570637_ChIP-Seq_MALME-3M_Human0.82762369
137IGF1R_20145208_ChIP-Seq_DFB_Human0.81917680
138SUZ12_27294783_Chip-Seq_ESCs_Mouse0.81846902
139HTT_18923047_ChIP-ChIP_STHdh_Human0.81304874
140SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81297000
141* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.79642890
142TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79035648
143DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78056573
144SMC3_22415368_ChIP-Seq_MEFs_Mouse0.77788440
145UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.77726591
146REST_18959480_ChIP-ChIP_MESCs_Mouse0.77098974
147EGR1_19032775_ChIP-ChIP_M12_Human0.75976291
148RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75909604
149PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75853377
150HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75585851
151KLF4_18555785_ChIP-Seq_MESCs_Mouse0.75542971
152CTBP1_25329375_ChIP-Seq_LNCAP_Human0.75490987
153BMI1_23680149_ChIP-Seq_NPCS_Mouse0.75199948
154SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75033036
155* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74020160
156CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.74013008
157SOX2_18692474_ChIP-Seq_MEFs_Mouse0.71658442
158* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.70136045
159PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.69850426
160PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.67003591
161KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.66162259

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.31699109
2MP0005084_abnormal_gallbladder_morpholo4.70036175
3MP0003646_muscle_fatigue4.51517002
4MP0000751_myopathy4.20987231
5MP0004084_abnormal_cardiac_muscle4.18913653
6MP0004215_abnormal_myocardial_fiber3.77852259
7MP0003693_abnormal_embryo_hatching3.67751287
8MP0004036_abnormal_muscle_relaxation3.35159278
9MP0004957_abnormal_blastocyst_morpholog3.23343801
10MP0005330_cardiomyopathy3.17252704
11MP0006036_abnormal_mitochondrial_physio2.97248590
12MP0005360_urolithiasis2.95314604
13MP0000749_muscle_degeneration2.94772673
14MP0008932_abnormal_embryonic_tissue2.90928758
15MP0003111_abnormal_nucleus_morphology2.70940640
16MP0010094_abnormal_chromosome_stability2.67117567
17MP0002972_abnormal_cardiac_muscle2.60536702
18MP0002163_abnormal_gland_morphology2.57498452
19MP0005408_hypopigmentation2.46275317
20MP0003137_abnormal_impulse_conducting2.43297995
21MP0008058_abnormal_DNA_repair2.40850624
22MP0004484_altered_response_of2.40259730
23MP0002139_abnormal_hepatobiliary_system2.40172227
24MP0008775_abnormal_heart_ventricle2.29890902
25MP0004130_abnormal_muscle_cell2.27224974
26MP0003718_maternal_effect2.24891987
27MP0000372_irregular_coat_pigmentation2.24263901
28MP0005085_abnormal_gallbladder_physiolo2.21352973
29MP0005620_abnormal_muscle_contractility2.21298105
30MP0004087_abnormal_muscle_fiber2.20610465
31MP0003077_abnormal_cell_cycle2.11517649
32MP0004147_increased_porphyrin_level2.07392791
33MP0005385_cardiovascular_system_phenoty2.06210877
34MP0001544_abnormal_cardiovascular_syste2.06210877
35MP0006035_abnormal_mitochondrial_morpho2.01476598
36MP0003806_abnormal_nucleotide_metabolis1.91822320
37MP0000750_abnormal_muscle_regeneration1.90353944
38MP0002106_abnormal_muscle_physiology1.89896311
39MP0005379_endocrine/exocrine_gland_phen1.89579105
40MP0006138_congestive_heart_failure1.87986436
41MP0003221_abnormal_cardiomyocyte_apopto1.81745113
42MP0004145_abnormal_muscle_electrophysio1.80510730
43MP0004043_abnormal_pH_regulation1.76920231
44MP0008875_abnormal_xenobiotic_pharmacok1.75171198
45MP0004085_abnormal_heartbeat1.74697998
46MP0002332_abnormal_exercise_endurance1.74664464
47MP0005332_abnormal_amino_acid1.73297300
48MP0001529_abnormal_vocalization1.72927680
49MP0003315_abnormal_perineum_morphology1.71361137
50MP0003011_delayed_dark_adaptation1.71040408
51MP0003195_calcinosis1.70032281
52MP0000747_muscle_weakness1.69992270
53MP0003941_abnormal_skin_development1.69233682
54MP0002269_muscular_atrophy1.65712718
55MP0010630_abnormal_cardiac_muscle1.59216781
56MP0003786_premature_aging1.57172056
57MP0005369_muscle_phenotype1.52918429
58MP0008995_early_reproductive_senescence1.51056195
59MP0006276_abnormal_autonomic_nervous1.48929707
60MP0004233_abnormal_muscle_weight1.45316513
61MP0005187_abnormal_penis_morphology1.45136718
62MP0002822_catalepsy1.42923939
63MP0005365_abnormal_bile_salt1.39078628
64MP0005451_abnormal_body_composition1.36692270
65MP0000759_abnormal_skeletal_muscle1.35847373
66MP0002877_abnormal_melanocyte_morpholog1.35100417
67MP0005220_abnormal_exocrine_pancreas1.33690969
68MP0002127_abnormal_cardiovascular_syste1.32380209
69MP0001764_abnormal_homeostasis1.31742937
70MP0008961_abnormal_basal_metabolism1.31197903
71MP0006072_abnormal_retinal_apoptosis1.30559718
72MP0009379_abnormal_foot_pigmentation1.29699366
73MP0005266_abnormal_metabolism1.28451370
74MP0005083_abnormal_biliary_tract1.27351055
75MP0002938_white_spotting1.23016321
76MP0003567_abnormal_fetal_cardiomyocyte1.22253706
77MP0004133_heterotaxia1.21455116
78MP0003828_pulmonary_edema1.16166949
79MP0002638_abnormal_pupillary_reflex1.15469925
80MP0003880_abnormal_central_pattern1.14328008
81MP0000350_abnormal_cell_proliferation1.08304539
82MP0000230_abnormal_systemic_arterial1.08003687
83MP0001440_abnormal_grooming_behavior1.05852762
84MP0003122_maternal_imprinting1.05625195
85MP0008007_abnormal_cellular_replicative1.03952067
86MP0002160_abnormal_reproductive_system1.02652643
87MP0005535_abnormal_body_temperature1.01690072
88MP0002909_abnormal_adrenal_gland0.98940563
89MP0005584_abnormal_enzyme/coenzyme_acti0.98316435
90MP0005165_increased_susceptibility_to0.98041842
91MP0000678_abnormal_parathyroid_gland0.96440454
92MP0004924_abnormal_behavior0.94331307
93MP0005386_behavior/neurological_phenoty0.94331307
94MP0001661_extended_life_span0.92846377
95MP0005319_abnormal_enzyme/_coenzyme0.92428087
96MP0001730_embryonic_growth_arrest0.89956303
97MP0002736_abnormal_nociception_after0.89899466
98MP0001727_abnormal_embryo_implantation0.89357360
99MP0000358_abnormal_cell_content/0.88900646
100MP0010329_abnormal_lipoprotein_level0.87799992
101MP0009643_abnormal_urine_homeostasis0.87781339
102MP0005636_abnormal_mineral_homeostasis0.87426540
103MP0003186_abnormal_redox_activity0.87412899
104MP0003878_abnormal_ear_physiology0.87052573
105MP0005377_hearing/vestibular/ear_phenot0.87052573
106MP0002132_abnormal_respiratory_system0.86998009
107MP0004142_abnormal_muscle_tone0.86197549
108MP0005666_abnormal_adipose_tissue0.85962209
109MP0001697_abnormal_embryo_size0.85607382
110MP0002928_abnormal_bile_duct0.84455031
111MP0003950_abnormal_plasma_membrane0.83659615
112MP0005380_embryogenesis_phenotype0.82997465
113MP0001672_abnormal_embryogenesis/_devel0.82997465
114MP0000313_abnormal_cell_death0.82521374
115MP0006292_abnormal_olfactory_placode0.81414427
116MP0002118_abnormal_lipid_homeostasis0.80161146
117MP0001881_abnormal_mammary_gland0.78465718
118MP0000343_altered_response_to0.76366213
119MP0005389_reproductive_system_phenotype0.74668543
120MP0002090_abnormal_vision0.74053474
121MP0003252_abnormal_bile_duct0.73169935
122MP0003984_embryonic_growth_retardation0.72516103
123MP0005376_homeostasis/metabolism_phenot0.72513129
124MP0001905_abnormal_dopamine_level0.72391373
125MP0000013_abnormal_adipose_tissue0.71702574
126MP0005410_abnormal_fertilization0.71395432
127MP0001968_abnormal_touch/_nociception0.71215901
128MP0002210_abnormal_sex_determination0.70870153
129MP0002080_prenatal_lethality0.70451883
130MP0009745_abnormal_behavioral_response0.70411369
131MP0002088_abnormal_embryonic_growth/wei0.69857986
132MP0005670_abnormal_white_adipose0.69805533
133MP0008789_abnormal_olfactory_epithelium0.69109162
134MP0002078_abnormal_glucose_homeostasis0.66974529
135MP0000462_abnormal_digestive_system0.65641927
136MP0002095_abnormal_skin_pigmentation0.65320284
137MP0001666_abnormal_nutrient_absorption0.65228045
138MP0000631_abnormal_neuroendocrine_gland0.63728988
139MP0001765_abnormal_ion_homeostasis0.62292910
140MP0001756_abnormal_urination0.62075020
141MP0002971_abnormal_brown_adipose0.61586985
142MP0004510_myositis0.60963801
143MP0002234_abnormal_pharynx_morphology0.59241456
144MP0002064_seizures0.58757494
145MP0004019_abnormal_vitamin_homeostasis0.56818827
146MP0000266_abnormal_heart_morphology0.56783799
147MP0009046_muscle_twitch0.56577529
148MP0002272_abnormal_nervous_system0.55863691
149MP0003635_abnormal_synaptic_transmissio0.55309561
150MP0005448_abnormal_energy_balance0.55177007
151MP0008872_abnormal_physiological_respon0.52771320
152MP0001485_abnormal_pinna_reflex0.51257830
153MP0009697_abnormal_copulation0.51146054
154MP0003123_paternal_imprinting0.50761522
155MP0009840_abnormal_foam_cell0.50172448

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.54331072
2Abnormal mitochondria in muscle tissue (HP:0008316)6.23468407
3Acute encephalopathy (HP:0006846)5.83992229
4Progressive macrocephaly (HP:0004481)5.54945139
5Mitochondrial inheritance (HP:0001427)5.22301952
6Sudden death (HP:0001699)5.00188518
7Cerebral edema (HP:0002181)4.87163044
8Increased CSF lactate (HP:0002490)4.67975231
9Hepatic necrosis (HP:0002605)4.61574273
10Hepatocellular necrosis (HP:0001404)4.44764741
11Calf muscle hypertrophy (HP:0008981)4.06919684
12Exercise-induced muscle cramps (HP:0003710)4.04004910
13Abnormality of glycolysis (HP:0004366)3.94847322
14Increased serum pyruvate (HP:0003542)3.94847322
15Muscle hypertrophy of the lower extremities (HP:0008968)3.86727708
16Palpitations (HP:0001962)3.86574634
17Ventricular tachycardia (HP:0004756)3.84464459
18Oral leukoplakia (HP:0002745)3.77919742
19Exercise-induced myalgia (HP:0003738)3.76563848
20Myoglobinuria (HP:0002913)3.72151451
21Exercise intolerance (HP:0003546)3.63571887
22Lactic acidosis (HP:0003128)3.63530986
23Increased intramyocellular lipid droplets (HP:0012240)3.62261585
24Increased muscle lipid content (HP:0009058)3.58791162
25Lipid accumulation in hepatocytes (HP:0006561)3.56897190
26Respiratory failure (HP:0002878)3.55793026
27Conjunctival hamartoma (HP:0100780)3.48126310
28Increased hepatocellular lipid droplets (HP:0006565)3.47226777
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.35131074
30Abnormality of renal resorption (HP:0011038)3.29375898
31Pheochromocytoma (HP:0002666)3.26452185
32Syncope (HP:0001279)3.25368871
33Atrial fibrillation (HP:0005110)3.25227017
34Macrocytic anemia (HP:0001972)3.24335571
35Abnormality of the calf musculature (HP:0001430)3.21946950
36Ketoacidosis (HP:0001993)3.20549509
37Ragged-red muscle fibers (HP:0003200)3.17729811
38Lipoatrophy (HP:0100578)3.14579296
39Muscle fiber splitting (HP:0003555)3.11693563
40Primary atrial arrhythmia (HP:0001692)3.09704995
41Optic disc pallor (HP:0000543)3.09332767
42Neuroendocrine neoplasm (HP:0100634)3.07086224
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.05877554
44Decreased activity of mitochondrial respiratory chain (HP:0008972)3.05877554
45Leukodystrophy (HP:0002415)3.05722180
46Supraventricular tachycardia (HP:0004755)3.04307383
47Right ventricular cardiomyopathy (HP:0011663)3.01209732
48Rhabdomyolysis (HP:0003201)2.99592446
49Supraventricular arrhythmia (HP:0005115)2.96743259
50Dicarboxylic aciduria (HP:0003215)2.91239648
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.91239648
52Lethargy (HP:0001254)2.86500990
53Hypoglycemic coma (HP:0001325)2.82496491
54Prolonged QT interval (HP:0001657)2.81007816
55Abnormality of fatty-acid metabolism (HP:0004359)2.79699280
56Increased serum lactate (HP:0002151)2.76874803
57Ketosis (HP:0001946)2.73344576
58EMG: myopathic abnormalities (HP:0003458)2.71145070
593-Methylglutaconic aciduria (HP:0003535)2.70935866
60Glycosuria (HP:0003076)2.70215190
61Abnormality of urine glucose concentration (HP:0011016)2.70215190
62Abnormality of cells of the erythroid lineage (HP:0012130)2.69629114
63Ventricular arrhythmia (HP:0004308)2.68032468
64Myotonia (HP:0002486)2.62789047
65Renal Fanconi syndrome (HP:0001994)2.62539960
66Dilated cardiomyopathy (HP:0001644)2.62356828
67Abnormal number of erythroid precursors (HP:0012131)2.59476315
68Reticulocytopenia (HP:0001896)2.58724959
69Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.58410442
70Ventricular fibrillation (HP:0001663)2.55842891
71Hyporeflexia of lower limbs (HP:0002600)2.55346158
72Hyperammonemia (HP:0001987)2.49041657
73Vomiting (HP:0002013)2.47067256
74Abnormality of the left ventricular outflow tract (HP:0011103)2.47003625
75Subaortic stenosis (HP:0001682)2.47003625
76Abnormality of serum amino acid levels (HP:0003112)2.46640235
77Muscle stiffness (HP:0003552)2.46269697
78Neoplasm of the adrenal gland (HP:0100631)2.42555644
79X-linked dominant inheritance (HP:0001423)2.37492059
80Generalized aminoaciduria (HP:0002909)2.33452329
81Hyperglycinemia (HP:0002154)2.31951525
82Metabolic acidosis (HP:0001942)2.30185427
83Abnormality of methionine metabolism (HP:0010901)2.30166173
84Asymmetric septal hypertrophy (HP:0001670)2.29415692
85Hyperglycinuria (HP:0003108)2.29363235
86Rough bone trabeculation (HP:0100670)2.27716214
87Pallor (HP:0000980)2.24462100
88Type I transferrin isoform profile (HP:0003642)2.24076071
89CNS demyelination (HP:0007305)2.22098096
90Degeneration of anterior horn cells (HP:0002398)2.21616086
91Abnormality of the anterior horn cell (HP:0006802)2.21616086
92Reduced antithrombin III activity (HP:0001976)2.19168959
93Anomalous pulmonary venous return (HP:0010772)2.17914050
94Bundle branch block (HP:0011710)2.15408664
95Respiratory difficulties (HP:0002880)2.14948548
96Neoplasm of head and neck (HP:0012288)2.14405759
97Esophageal neoplasm (HP:0100751)2.14405759
98Abnormality of alanine metabolism (HP:0010916)2.12660909
99Hyperalaninemia (HP:0003348)2.12660909
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12660909
101Hyperphosphaturia (HP:0003109)2.08523325
102Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07484507
103Nausea (HP:0002018)2.05986826
104Abnormality of aromatic amino acid family metabolism (HP:0004338)2.05740799
105Cerebral hypomyelination (HP:0006808)2.05718467
106Proximal tubulopathy (HP:0000114)2.05327976
107Microvesicular hepatic steatosis (HP:0001414)2.05272279
108Abnormality of glycine metabolism (HP:0010895)2.04691680
109Abnormality of serine family amino acid metabolism (HP:0010894)2.04691680
110Hamartoma of the eye (HP:0010568)2.04485553
111Abnormality of placental membranes (HP:0011409)2.04060451
112Amniotic constriction ring (HP:0009775)2.04060451
113Muscle fiber inclusion bodies (HP:0100299)2.02026034
114Multiple enchondromatosis (HP:0005701)1.99266516
115Abnormal gallbladder physiology (HP:0012438)1.99182127
116Cholecystitis (HP:0001082)1.99182127
117Athetosis (HP:0002305)1.98683137
118Megaloblastic anemia (HP:0001889)1.97876934
119Nemaline bodies (HP:0003798)1.97768513
120Abnormal EKG (HP:0003115)1.96643877
121Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.96602888
122Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96566368
123Abnormality of the pulmonary veins (HP:0011718)1.96162353
124Left ventricular hypertrophy (HP:0001712)1.94777968
125Emotional lability (HP:0000712)1.94711048
126Methylmalonic acidemia (HP:0002912)1.92848399
127Methylmalonic aciduria (HP:0012120)1.92016872
128Heart block (HP:0012722)1.91727125
129Progressive muscle weakness (HP:0003323)1.90647386
130Cavernous hemangioma (HP:0001048)1.90562096
131Gout (HP:0001997)1.90458463
132Abnormal urine phosphate concentration (HP:0012599)1.90314264
133Abnormality of sulfur amino acid metabolism (HP:0004339)1.88333543
134Exertional dyspnea (HP:0002875)1.87159636
135Birth length less than 3rd percentile (HP:0003561)1.86182479
136Abnormal trabecular bone morphology (HP:0100671)1.83184967
137Renal tubular dysfunction (HP:0000124)1.80991597
138Aplastic anemia (HP:0001915)1.79915242
139Congenital, generalized hypertrichosis (HP:0004540)1.75187406
140Premature graying of hair (HP:0002216)1.74456394
141Hypobetalipoproteinemia (HP:0003563)1.67174460
142Abnormality of purine metabolism (HP:0004352)1.64452446
143Abnormal glycosylation (HP:0012345)1.63573626

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.32487614
2MYLK3.96378624
3OBSCN3.90612767
4NME23.43303738
5BCKDK3.23612275
6TTN3.09528361
7NME13.08591999
8BLK3.04928255
9LMTK22.93443810
10STK162.93303622
11WNK42.93061094
12PDK32.84547749
13PDK42.84547749
14PBK2.77570301
15PHKG22.69299781
16PHKG12.69299781
17VRK22.68461818
18CDC72.64070214
19SRPK12.57531946
20EIF2AK12.54264589
21NEK12.32033656
22ARAF2.27709686
23MAP3K122.27256146
24ZAK2.23802524
25PKN22.17126625
26STK242.09670968
27TTK2.00733051
28VRK11.89897295
29STK391.86580023
30PLK41.83290068
31TAF11.79601316
32LIMK11.76053040
33GRK71.75585673
34TLK11.65859383
35ILK1.62891334
36MUSK1.59909461
37SCYL21.56263886
38PIK3CA1.54570809
39PDK21.53938852
40TRIB31.53738572
41TSSK61.52916552
42MAP2K41.52842035
43STK41.48219880
44WEE11.47628196
45EIF2AK31.41061154
46NTRK21.35402895
47PAK31.32621906
48CAMK2D1.31324661
49GRK51.27642599
50PLK31.27017767
51PLK11.23556883
52OXSR11.18683990
53STK38L1.17979500
54PINK11.15931481
55MST1R1.15805899
56AURKB1.15053436
57CCNB11.14627089
58DAPK31.13164463
59WNK31.11875679
60KSR21.11015905
61TIE11.09749216
62MAP3K41.05509890
63TESK21.04697427
64CAMK2A1.04120130
65PRKCI1.00912749
66DMPK0.98410488
67PIM20.97979543
68MAPK120.97902662
69MAP4K20.95796308
70CSNK1G30.95559985
71MAP3K110.95542581
72AURKA0.93915994
73CAMK2G0.93001005
74MAP3K70.91708644
75PAK40.91589780
76MINK10.90775336
77BRSK10.90553407
78MAP3K90.88386050
79PTK2B0.87268568
80TRIM280.81828903
81BRSK20.79254872
82STK30.77059004
83CSNK2A20.75103269
84ABL20.73856784
85CDK190.73443697
86CSNK2A10.72515552
87CHEK20.71821360
88CSNK1G20.70435020
89ROCK10.70185895
90CSNK1G10.69408459
91MST40.69244560
92ROCK20.68556377
93ADRBK10.66821070
94MAP3K50.66723660
95CAMK2B0.66284907
96RPS6KA50.65624429
97MAP2K10.65126798
98TAOK20.63634326
99ATR0.63464203
100PRKACA0.63377225
101GRK60.63205597
102LATS20.62072065
103UHMK10.61953811
104PRKD10.60485182
105PRKAA20.59785151
106PNCK0.59289734
107EPHA40.58926606
108KDR0.58168654
109CSNK1A1L0.57914592
110MAP3K80.55943694
111PLK20.55746638
112MAP2K70.54611776
113PAK10.53277808
114MKNK10.52104628
115DAPK10.50815836
116RPS6KB20.50485870
117CDC42BPA0.50423013
118NUAK10.49512833
119PRKACG0.49370276
120PRKCE0.48935026
121PRKAA10.47976444
122AKT20.47415546
123BMPR20.46681046
124KSR10.46613057
125PRKG20.46604082
126CAMK40.46070949
127CDK11A0.44641011
128PKN10.44230464
129CHEK10.43609835
130RPS6KA40.43091719
131DYRK20.42459654
132CDK180.42225469
133CLK10.41365260
134MATK0.39816487
135EIF2AK20.39560505
136BRAF0.38930421
137CAMK10.38443529
138WNK10.38332501
139CDK80.37957385
140INSRR0.37909231
141RAF10.37434473
142PRPF4B0.37251550
143EPHB20.37132242
144MARK10.36331013
145CDK140.35577195
146PRKACB0.34615814
147PRKCG0.34241260
148CDK70.33997302
149PIK3CG0.32557681
150PAK60.32251475
151NTRK30.31300059
152MAP2K60.30893545
153DYRK30.30864550
154MAPKAPK50.30113870
155CDK30.28457010
156CAMKK20.28062873
157MAPK40.27846566
158MOS0.26217484
159PRKCA0.25476566
160ERBB40.23050304
161LRRK20.21876186
162PDPK10.21232234
163TESK10.20638076
164CDK150.20473677

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001905.30266563
2Parkinsons disease_Homo sapiens_hsa050124.85074705
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.41171892
4Alzheimers disease_Homo sapiens_hsa050103.57900862
5Cardiac muscle contraction_Homo sapiens_hsa042603.54934647
6Huntingtons disease_Homo sapiens_hsa050163.21916527
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.16666618
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.09887698
9DNA replication_Homo sapiens_hsa030302.81276195
10Propanoate metabolism_Homo sapiens_hsa006402.80564497
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.52506052
12Mismatch repair_Homo sapiens_hsa034302.45665353
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.43592499
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32081818
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29555789
16Pyruvate metabolism_Homo sapiens_hsa006202.21804325
17RNA polymerase_Homo sapiens_hsa030202.21682629
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14549438
19Carbon metabolism_Homo sapiens_hsa012002.14012294
20Fatty acid degradation_Homo sapiens_hsa000712.08506176
21Butanoate metabolism_Homo sapiens_hsa006502.00794946
22Homologous recombination_Homo sapiens_hsa034401.82708613
23Sulfur metabolism_Homo sapiens_hsa009201.63494970
24One carbon pool by folate_Homo sapiens_hsa006701.56796287
25Spliceosome_Homo sapiens_hsa030401.54959398
26Fatty acid metabolism_Homo sapiens_hsa012121.53451103
27Base excision repair_Homo sapiens_hsa034101.50741536
28Pyrimidine metabolism_Homo sapiens_hsa002401.49455254
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48771076
30Nucleotide excision repair_Homo sapiens_hsa034201.41006886
31Fatty acid elongation_Homo sapiens_hsa000621.39807475
32Ribosome_Homo sapiens_hsa030101.33062363
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32975661
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.31487540
35Tryptophan metabolism_Homo sapiens_hsa003801.25322980
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22188206
37Dilated cardiomyopathy_Homo sapiens_hsa054141.22076506
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.20923283
39RNA transport_Homo sapiens_hsa030131.20453283
40Peroxisome_Homo sapiens_hsa041461.19346205
41Phenylalanine metabolism_Homo sapiens_hsa003601.17747396
42Purine metabolism_Homo sapiens_hsa002301.17708826
43Arginine biosynthesis_Homo sapiens_hsa002201.16521667
44Biosynthesis of amino acids_Homo sapiens_hsa012301.11349382
45Proteasome_Homo sapiens_hsa030501.10203261
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09812272
47PPAR signaling pathway_Homo sapiens_hsa033201.08474866
48beta-Alanine metabolism_Homo sapiens_hsa004101.04997079
49RNA degradation_Homo sapiens_hsa030181.03634270
50Fanconi anemia pathway_Homo sapiens_hsa034601.00169925
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.99431470
52Tyrosine metabolism_Homo sapiens_hsa003500.95270767
53Starch and sucrose metabolism_Homo sapiens_hsa005000.87485080
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86577859
55Vitamin B6 metabolism_Homo sapiens_hsa007500.85654651
56Collecting duct acid secretion_Homo sapiens_hsa049660.83747839
57Basal transcription factors_Homo sapiens_hsa030220.82389588
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81408223
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80677002
60Steroid biosynthesis_Homo sapiens_hsa001000.79851170
61Arginine and proline metabolism_Homo sapiens_hsa003300.79525902
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78615790
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77170998
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.74329970
65Fat digestion and absorption_Homo sapiens_hsa049750.74175798
66* Metabolic pathways_Homo sapiens_hsa011000.72877238
67Systemic lupus erythematosus_Homo sapiens_hsa053220.70716404
68Cell cycle_Homo sapiens_hsa041100.70278511
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69899505
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64301783
71Glutathione metabolism_Homo sapiens_hsa004800.62888335
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61575817
73Chemical carcinogenesis_Homo sapiens_hsa052040.60537907
74Bile secretion_Homo sapiens_hsa049760.60354221
75Non-homologous end-joining_Homo sapiens_hsa034500.58853553
76Histidine metabolism_Homo sapiens_hsa003400.57733934
77Fructose and mannose metabolism_Homo sapiens_hsa000510.55996315
78Olfactory transduction_Homo sapiens_hsa047400.53966072
79Oocyte meiosis_Homo sapiens_hsa041140.52010542
80Galactose metabolism_Homo sapiens_hsa000520.50390045
81Sulfur relay system_Homo sapiens_hsa041220.46214265
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45878872
83Glucagon signaling pathway_Homo sapiens_hsa049220.44873199
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43017955
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40567134
86Vitamin digestion and absorption_Homo sapiens_hsa049770.39811615
87Vibrio cholerae infection_Homo sapiens_hsa051100.39800886
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38728599
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35801424
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.34365223
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31784871
92Nitrogen metabolism_Homo sapiens_hsa009100.30345985
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.30167160
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.29174340
95Calcium signaling pathway_Homo sapiens_hsa040200.29026237
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.28922612
97Pentose phosphate pathway_Homo sapiens_hsa000300.27849868
98Folate biosynthesis_Homo sapiens_hsa007900.27727885
99Alcoholism_Homo sapiens_hsa050340.26888775
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25848416
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25671624
102Synaptic vesicle cycle_Homo sapiens_hsa047210.24016972
103Ovarian steroidogenesis_Homo sapiens_hsa049130.23766256
104N-Glycan biosynthesis_Homo sapiens_hsa005100.23006114
105Glycerolipid metabolism_Homo sapiens_hsa005610.22570993
106Protein export_Homo sapiens_hsa030600.22187386
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.21931771
108Renin secretion_Homo sapiens_hsa049240.21203780
109Gastric acid secretion_Homo sapiens_hsa049710.21189880
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20857250
111Retinol metabolism_Homo sapiens_hsa008300.20813616
112GABAergic synapse_Homo sapiens_hsa047270.20602061
113Insulin signaling pathway_Homo sapiens_hsa049100.20403302
114Renin-angiotensin system_Homo sapiens_hsa046140.20351879
115Arachidonic acid metabolism_Homo sapiens_hsa005900.20313701
116Selenocompound metabolism_Homo sapiens_hsa004500.19985277
117Mineral absorption_Homo sapiens_hsa049780.19653933
118Nicotine addiction_Homo sapiens_hsa050330.19615413
119Linoleic acid metabolism_Homo sapiens_hsa005910.19317491
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.19225454
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.19019830
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18964415
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18862338
124Caffeine metabolism_Homo sapiens_hsa002320.18228834
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17619807
126Complement and coagulation cascades_Homo sapiens_hsa046100.17114366
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16524825
128Viral myocarditis_Homo sapiens_hsa054160.16176521
129Oxytocin signaling pathway_Homo sapiens_hsa049210.15360059
130Taste transduction_Homo sapiens_hsa047420.12307671
131Insulin resistance_Homo sapiens_hsa049310.11700422
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.11568151
133Dopaminergic synapse_Homo sapiens_hsa047280.09748075
134AMPK signaling pathway_Homo sapiens_hsa041520.08395655
135Serotonergic synapse_Homo sapiens_hsa047260.08145998
136Circadian entrainment_Homo sapiens_hsa047130.07330589

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