ATP5HP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.79498541
2behavioral response to nicotine (GO:0035095)7.48612338
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.34419250
4ATP synthesis coupled proton transport (GO:0015986)7.34419250
5preassembly of GPI anchor in ER membrane (GO:0016254)5.91455882
6chaperone-mediated protein transport (GO:0072321)5.49090588
7establishment of protein localization to mitochondrial membrane (GO:0090151)5.35174730
8negative regulation of heart rate (GO:0010459)4.99609597
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.88853544
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.71877056
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.64416434
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.64416434
13NADH dehydrogenase complex assembly (GO:0010257)4.64416434
14positive regulation of protein homodimerization activity (GO:0090073)4.62865673
15DNA deamination (GO:0045006)4.58415625
16GPI anchor biosynthetic process (GO:0006506)4.50550927
17protein complex biogenesis (GO:0070271)4.49324240
18respiratory electron transport chain (GO:0022904)4.46813645
19electron transport chain (GO:0022900)4.45760239
20neuron fate determination (GO:0048664)4.34721658
21GPI anchor metabolic process (GO:0006505)4.34378279
22ATP biosynthetic process (GO:0006754)4.29285153
23mitochondrial respiratory chain complex assembly (GO:0033108)4.17210770
24negative regulation of calcium ion transport into cytosol (GO:0010523)4.04003699
25regulation of hypersensitivity (GO:0002883)3.96378444
26positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.90358653
27purine nucleoside triphosphate biosynthetic process (GO:0009145)3.86813538
28neuronal action potential propagation (GO:0019227)3.84506500
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.81110056
30purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.76746979
31hepatocyte differentiation (GO:0070365)3.70786712
32maturation of SSU-rRNA (GO:0030490)3.67950608
33C-terminal protein lipidation (GO:0006501)3.67641070
34negative regulation of mast cell activation (GO:0033004)3.63429541
35protein peptidyl-prolyl isomerization (GO:0000413)3.62163973
36rRNA modification (GO:0000154)3.55680722
37protein neddylation (GO:0045116)3.50908224
38positive regulation of T cell cytokine production (GO:0002726)3.44184175
39ribosomal large subunit biogenesis (GO:0042273)3.41593836
40respiratory chain complex IV assembly (GO:0008535)3.38648167
41positive regulation of oligodendrocyte differentiation (GO:0048714)3.36730339
42axoneme assembly (GO:0035082)3.35724392
43positive regulation of growth hormone secretion (GO:0060124)3.33463796
44ribonucleoside triphosphate biosynthetic process (GO:0009201)3.33096628
45epithelial cilium movement (GO:0003351)3.32581578
46hydrogen ion transmembrane transport (GO:1902600)3.31420107
47protein polyglutamylation (GO:0018095)3.31391780
48intracellular protein transmembrane import (GO:0044743)3.29110348
49pseudouridine synthesis (GO:0001522)3.28148512
50ribosomal small subunit biogenesis (GO:0042274)3.23781877
51rRNA methylation (GO:0031167)3.23619508
52protein maturation by protein folding (GO:0022417)3.19133800
53mannosylation (GO:0097502)3.18350466
54ribosomal small subunit assembly (GO:0000028)3.17747410
55translational termination (GO:0006415)3.14998345
56C-terminal protein amino acid modification (GO:0018410)3.12081019
57viral transcription (GO:0019083)3.07685423
58termination of RNA polymerase III transcription (GO:0006386)3.07551390
59transcription elongation from RNA polymerase III promoter (GO:0006385)3.07551390
60maturation of 5.8S rRNA (GO:0000460)3.07231798
61cytidine deamination (GO:0009972)3.05602153
62cytidine metabolic process (GO:0046087)3.05602153
63cytidine catabolic process (GO:0006216)3.05602153
64dentate gyrus development (GO:0021542)3.05097308
65protein targeting to ER (GO:0045047)3.01537644
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99395099
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99395099
68regulation of action potential (GO:0098900)2.98291068
69regulation of cellular respiration (GO:0043457)2.98086014
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97850874
71SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97141322
72cotranslational protein targeting to membrane (GO:0006613)2.95261360
73positive regulation of cellular response to oxidative stress (GO:1900409)2.95011068
74positive regulation of response to oxidative stress (GO:1902884)2.95011068
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92834185
76proton transport (GO:0015992)2.92703755
77synaptic transmission, cholinergic (GO:0007271)2.92635285
78nucleoside triphosphate biosynthetic process (GO:0009142)2.92114656
79regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.90525140
80regulation of circadian sleep/wake cycle (GO:0042749)2.90525140
81regulation of growth hormone secretion (GO:0060123)2.90340913
82positive regulation of mast cell degranulation (GO:0043306)2.89995712
83positive regulation of mast cell activation involved in immune response (GO:0033008)2.89995712
84regulation of cellular amino acid metabolic process (GO:0006521)2.87964725
85hydrogen transport (GO:0006818)2.84378407
86establishment of protein localization to endoplasmic reticulum (GO:0072599)2.83786932
87response to vitamin E (GO:0033197)2.83181382
88cellular response to interferon-beta (GO:0035458)2.80597390
89regulation of autophagic vacuole assembly (GO:2000785)2.80466689
90protein localization to endoplasmic reticulum (GO:0070972)2.78532718
91cellular component biogenesis (GO:0044085)2.76763089
92negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.75395659
93cytochrome complex assembly (GO:0017004)2.74006371
94purine nucleoside monophosphate biosynthetic process (GO:0009127)2.73139572
95purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.73139572
96thalamus development (GO:0021794)2.72671337
97apoptotic DNA fragmentation (GO:0006309)2.71313578
98pyrimidine ribonucleoside catabolic process (GO:0046133)2.70366488
99dopamine transport (GO:0015872)2.67998003
100regulation of sarcomere organization (GO:0060297)2.66510444

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.34817010
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.19277623
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.04364914
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.86948667
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.36707068
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.35500751
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.05246991
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86076586
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.79142292
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.74663120
11EZH2_22144423_ChIP-Seq_EOC_Human2.67862343
12ZNF274_21170338_ChIP-Seq_K562_Hela2.62189568
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57215125
14TAF15_26573619_Chip-Seq_HEK293_Human2.52945117
15VDR_22108803_ChIP-Seq_LS180_Human2.40823564
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38207604
17VDR_23849224_ChIP-Seq_CD4+_Human2.26268845
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.14889373
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.11709100
20YY1_21170310_ChIP-Seq_MESCs_Mouse2.07793904
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00546510
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.98923708
23ELK1_19687146_ChIP-ChIP_HELA_Human1.79835844
24TTF2_22483619_ChIP-Seq_HELA_Human1.75330779
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71276439
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67313119
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66985285
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.62784352
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59093238
30FOXP3_21729870_ChIP-Seq_TREG_Human1.56824523
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56567231
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.56549815
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52561137
34EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.50984897
35TP53_22573176_ChIP-Seq_HFKS_Human1.47604995
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47476767
37NANOG_19829295_ChIP-Seq_ESCs_Human1.42761332
38SOX2_19829295_ChIP-Seq_ESCs_Human1.42761332
39MYC_18940864_ChIP-ChIP_HL60_Human1.41236159
40GATA3_21878914_ChIP-Seq_MCF-7_Human1.39384375
41AR_21572438_ChIP-Seq_LNCaP_Human1.38060633
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.37442372
43DCP1A_22483619_ChIP-Seq_HELA_Human1.34340008
44EWS_26573619_Chip-Seq_HEK293_Human1.33100878
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32847519
46IRF1_19129219_ChIP-ChIP_H3396_Human1.30271245
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28874332
48NCOR_22424771_ChIP-Seq_293T_Human1.27948100
49PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.23465834
50ERA_21632823_ChIP-Seq_H3396_Human1.22525802
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22097901
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21217856
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21163645
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20461082
55FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18437530
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17416291
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15823572
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15237978
59ER_23166858_ChIP-Seq_MCF-7_Human1.15087716
60GATA3_26560356_Chip-Seq_TH2_Human1.14769967
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13717511
62AR_20517297_ChIP-Seq_VCAP_Human1.13333921
63GABP_19822575_ChIP-Seq_HepG2_Human1.12306536
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09144103
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.07385031
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06959065
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06134355
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06134355
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06117079
70CIITA_25753668_ChIP-Seq_RAJI_Human1.04784917
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04701104
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04581951
73P300_19829295_ChIP-Seq_ESCs_Human1.03644912
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02809337
75ELF5_23300383_ChIP-Seq_T47D_Human1.01363094
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01185347
77TAF2_19829295_ChIP-Seq_ESCs_Human1.00382407
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00295203
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99293392
80CBX2_27304074_Chip-Seq_ESCs_Mouse0.99169075
81TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99106831
82FOXA1_25329375_ChIP-Seq_VCAP_Human0.98575219
83FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98575219
84AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98065183
85NANOG_20526341_ChIP-Seq_ESCs_Human0.97623247
86HOXB7_26014856_ChIP-Seq_BT474_Human0.96397549
87P53_21459846_ChIP-Seq_SAOS-2_Human0.95427578
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93680571
89RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93554103
90ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93067423
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92585164
92E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92307495
93ERG_20517297_ChIP-Seq_VCAP_Human0.92009599
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91332919
95MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91003827
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90091830
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89146632
98EZH2_27294783_Chip-Seq_NPCs_Mouse0.88939269
99ELK1_22589737_ChIP-Seq_MCF10A_Human0.88196034
100CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87962943

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation3.69762753
2MP0006292_abnormal_olfactory_placode3.65199634
3MP0002163_abnormal_gland_morphology3.24290689
4MP0002638_abnormal_pupillary_reflex3.12974348
5MP0009379_abnormal_foot_pigmentation2.99217813
6MP0003787_abnormal_imprinting2.79137608
7MP0005645_abnormal_hypothalamus_physiol2.78473918
8MP0005084_abnormal_gallbladder_morpholo2.69960496
9MP0002102_abnormal_ear_morphology2.60227204
10MP0000685_abnormal_immune_system2.54124275
11MP0003724_increased_susceptibility_to2.42905792
12MP0008872_abnormal_physiological_respon2.36369073
13MP0003950_abnormal_plasma_membrane2.34151020
14MP0010386_abnormal_urinary_bladder2.17382173
15MP0005671_abnormal_response_to2.07669685
16MP0009333_abnormal_splenocyte_physiolog1.94514353
17MP0005379_endocrine/exocrine_gland_phen1.88213787
18MP0008995_early_reproductive_senescence1.84925848
19MP0001968_abnormal_touch/_nociception1.79813957
20MP0003195_calcinosis1.75926124
21MP0001502_abnormal_circadian_rhythm1.74445525
22MP0001905_abnormal_dopamine_level1.73633578
23MP0004147_increased_porphyrin_level1.71561875
24MP0001919_abnormal_reproductive_system1.69562601
25MP0002736_abnormal_nociception_after1.68549389
26MP0002138_abnormal_hepatobiliary_system1.66426259
27MP0004742_abnormal_vestibular_system1.65302766
28MP0004885_abnormal_endolymph1.59880883
29MP0008875_abnormal_xenobiotic_pharmacok1.59101496
30MP0008877_abnormal_DNA_methylation1.55678206
31MP0005389_reproductive_system_phenotype1.54624072
32MP0005551_abnormal_eye_electrophysiolog1.52455690
33MP0005387_immune_system_phenotype1.45448113
34MP0001790_abnormal_immune_system1.45448113
35MP0004381_abnormal_hair_follicle1.45377772
36MP0005167_abnormal_blood-brain_barrier1.45139544
37MP0008789_abnormal_olfactory_epithelium1.44675867
38MP0001800_abnormal_humoral_immune1.44463452
39MP0004142_abnormal_muscle_tone1.42019658
40MP0003252_abnormal_bile_duct1.38657060
41MP0002148_abnormal_hypersensitivity_rea1.37781384
42MP0008775_abnormal_heart_ventricle1.37645889
43MP0001835_abnormal_antigen_presentation1.37634764
44MP0006276_abnormal_autonomic_nervous1.35645641
45MP0004043_abnormal_pH_regulation1.33933382
46MP0003123_paternal_imprinting1.32716978
47MP0005075_abnormal_melanosome_morpholog1.31597209
48MP0002876_abnormal_thyroid_physiology1.30866722
49MP0002272_abnormal_nervous_system1.28205985
50MP0001986_abnormal_taste_sensitivity1.26678871
51MP0006072_abnormal_retinal_apoptosis1.26213852
52MP0002160_abnormal_reproductive_system1.23433891
53MP0002653_abnormal_ependyma_morphology1.21886081
54MP0002095_abnormal_skin_pigmentation1.21267204
55MP0003880_abnormal_central_pattern1.19918316
56MP0003646_muscle_fatigue1.19104137
57MP0006035_abnormal_mitochondrial_morpho1.18003384
58MP0002938_white_spotting1.17322869
59MP0006036_abnormal_mitochondrial_physio1.15215721
60MP0003567_abnormal_fetal_cardiomyocyte1.15005038
61MP0001542_abnormal_bone_strength1.13812118
62MP0003786_premature_aging1.12856001
63MP0009785_altered_susceptibility_to1.08077916
64MP0005377_hearing/vestibular/ear_phenot1.04626434
65MP0003878_abnormal_ear_physiology1.04626434
66MP0000538_abnormal_urinary_bladder1.01677640
67MP0001970_abnormal_pain_threshold0.99283904
68MP0003866_abnormal_defecation0.98406589
69MP0009745_abnormal_behavioral_response0.97551181
70MP0002928_abnormal_bile_duct0.96819553
71MP0003186_abnormal_redox_activity0.96294452
72MP0001485_abnormal_pinna_reflex0.95379447
73MP0005253_abnormal_eye_physiology0.91429063
74MP0003137_abnormal_impulse_conducting0.89880934
75MP0002234_abnormal_pharynx_morphology0.84753381
76MP0004145_abnormal_muscle_electrophysio0.83842193
77MP0002229_neurodegeneration0.82507470
78MP0003436_decreased_susceptibility_to0.81130066
79MP0001501_abnormal_sleep_pattern0.80710102
80MP0003136_yellow_coat_color0.80199198
81MP0005085_abnormal_gallbladder_physiolo0.79765883
82MP0002909_abnormal_adrenal_gland0.78327346
83MP0000631_abnormal_neuroendocrine_gland0.78259624
84MP0000026_abnormal_inner_ear0.78160466
85MP0002723_abnormal_immune_serum0.77208097
86MP0005499_abnormal_olfactory_system0.76890111
87MP0005394_taste/olfaction_phenotype0.76890111
88MP0009764_decreased_sensitivity_to0.74687876
89MP0004133_heterotaxia0.74304362
90MP0005332_abnormal_amino_acid0.74239070
91MP0002452_abnormal_antigen_presenting0.73675068
92MP0002752_abnormal_somatic_nervous0.72147299
93MP0001765_abnormal_ion_homeostasis0.69567890
94MP0002184_abnormal_innervation0.69222118
95MP0002557_abnormal_social/conspecific_i0.67443744
96MP0002572_abnormal_emotion/affect_behav0.65394818
97MP0002751_abnormal_autonomic_nervous0.64911459
98MP0003283_abnormal_digestive_organ0.64839729
99MP0005195_abnormal_posterior_eye0.64427629
100MP0005636_abnormal_mineral_homeostasis0.62222653

Predicted human phenotypes

RankGene SetZ-score
1Lipid accumulation in hepatocytes (HP:0006561)4.54846656
2Increased hepatocellular lipid droplets (HP:0006565)4.43960187
3Increased CSF lactate (HP:0002490)4.21721719
4Mitochondrial inheritance (HP:0001427)4.10351332
5Acute necrotizing encephalopathy (HP:0006965)4.05556864
6Abnormality of midbrain morphology (HP:0002418)4.04033631
7Molar tooth sign on MRI (HP:0002419)4.04033631
83-Methylglutaconic aciduria (HP:0003535)3.66569042
9Abnormal mitochondria in muscle tissue (HP:0008316)3.57231819
10Acute encephalopathy (HP:0006846)3.56566170
11Testicular atrophy (HP:0000029)3.41415317
12Increased serum pyruvate (HP:0003542)3.28990603
13Progressive macrocephaly (HP:0004481)3.28958753
14Metaphyseal dysplasia (HP:0100255)3.20675231
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.19938088
16Renal Fanconi syndrome (HP:0001994)3.14917007
17Hepatocellular necrosis (HP:0001404)3.05304996
18Abnormality of the pons (HP:0007361)2.99988812
19Azoospermia (HP:0000027)2.97277036
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.92462377
21Stomatitis (HP:0010280)2.83776470
22Nephronophthisis (HP:0000090)2.82435901
23Increased intramyocellular lipid droplets (HP:0012240)2.81803360
24Cerebral edema (HP:0002181)2.79743634
25Exertional dyspnea (HP:0002875)2.79191104
26Double outlet right ventricle (HP:0001719)2.77160783
27Congenital malformation of the right heart (HP:0011723)2.77160783
28Hepatic necrosis (HP:0002605)2.72817552
29Abnormality of glycolysis (HP:0004366)2.71304389
30Supernumerary spleens (HP:0009799)2.68279020
31Opisthotonus (HP:0002179)2.68230828
32Type I transferrin isoform profile (HP:0003642)2.67093823
33Increased serum lactate (HP:0002151)2.62015815
34IgG deficiency (HP:0004315)2.61422691
35Increased muscle lipid content (HP:0009058)2.59842650
36Pendular nystagmus (HP:0012043)2.59627007
37Tubular atrophy (HP:0000092)2.59371013
38Abnormality of the renal medulla (HP:0100957)2.58185078
39Respiratory difficulties (HP:0002880)2.56410668
40Congenital, generalized hypertrichosis (HP:0004540)2.53564083
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.51053410
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.51053410
43Elevated erythrocyte sedimentation rate (HP:0003565)2.47252338
44Pancreatic fibrosis (HP:0100732)2.43887759
45Exercise intolerance (HP:0003546)2.43359214
46Severe combined immunodeficiency (HP:0004430)2.39767777
47Pancreatic cysts (HP:0001737)2.33847742
48Type 2 muscle fiber atrophy (HP:0003554)2.30609687
49Congenital stationary night blindness (HP:0007642)2.25608443
50Lactic acidosis (HP:0003128)2.24302330
51Premature ovarian failure (HP:0008209)2.23026195
52Reticulocytopenia (HP:0001896)2.22599608
53Hypoplasia of the pons (HP:0012110)2.21767556
54Abnormality of cells of the erythroid lineage (HP:0012130)2.20398150
55Abnormality of the renal cortex (HP:0011035)2.19827582
56Optic disc pallor (HP:0000543)2.18335568
57Abnormal spermatogenesis (HP:0008669)2.12952403
58Macrocytic anemia (HP:0001972)2.12802246
59Neoplasm of the adrenal cortex (HP:0100641)2.12110650
60Polydipsia (HP:0001959)2.10386021
61Abnormal drinking behavior (HP:0030082)2.10386021
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10383133
63Abnormality of alanine metabolism (HP:0010916)2.10383133
64Hyperalaninemia (HP:0003348)2.10383133
65Leukodystrophy (HP:0002415)2.09489120
66Hyperphosphaturia (HP:0003109)2.08582489
67Concave nail (HP:0001598)2.08165144
68Hypomagnesemia (HP:0002917)2.07395178
69Respiratory failure (HP:0002878)2.05952368
70Glycosuria (HP:0003076)2.04819888
71Abnormality of urine glucose concentration (HP:0011016)2.04819888
72Abnormality of renal resorption (HP:0011038)2.04518657
73Neoplasm of the tracheobronchial system (HP:0100552)2.04123158
74Adrenal hypoplasia (HP:0000835)2.02576448
75Muscle fiber atrophy (HP:0100295)2.00508017
76Dynein arm defect of respiratory motile cilia (HP:0012255)1.99450508
77Absent/shortened dynein arms (HP:0200106)1.99450508
78Lethargy (HP:0001254)1.98539126
79Type II lissencephaly (HP:0007260)1.98087585
80Polyuria (HP:0000103)1.97491554
81Microvesicular hepatic steatosis (HP:0001414)1.96272915
82Alveolar cell carcinoma (HP:0006519)1.95828698
83Abnormal protein N-linked glycosylation (HP:0012347)1.95092664
84Abnormal protein glycosylation (HP:0012346)1.95092664
85Abnormal glycosylation (HP:0012345)1.95092664
86Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95092664
87Abnormality of magnesium homeostasis (HP:0004921)1.93850902
88Arthropathy (HP:0003040)1.93603576
89Chronic sinusitis (HP:0011109)1.92141506
90CNS demyelination (HP:0007305)1.91878991
91Rib fusion (HP:0000902)1.88005544
92Hypoproteinemia (HP:0003075)1.86589420
93Asplenia (HP:0001746)1.86505803
94Abnormal respiratory motile cilium morphology (HP:0005938)1.85369833
95Abnormal respiratory epithelium morphology (HP:0012253)1.85369833
96Aplasia/Hypoplasia of the spleen (HP:0010451)1.84204319
97Rhabdomyosarcoma (HP:0002859)1.83981392
98Abnormal urine output (HP:0012590)1.82890814
99Large eyes (HP:0001090)1.82196265
100Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81141526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.35142996
2SCYL24.29262642
3NUAK13.55609403
4MAP3K123.29384553
5TAOK32.94054044
6WNK42.46354921
7CAMKK22.46021167
8ZAK2.45628204
9GRK12.44650646
10TSSK62.22677329
11MST42.19010870
12ADRBK22.09837129
13MAP4K21.99922082
14PINK11.91001156
15PDK21.84066272
16MAPKAPK31.68837560
17BMPR21.56880960
18VRK21.51904292
19FRK1.51545495
20TRIM281.49557357
21DAPK21.49173610
22TAF11.48505281
23MYLK1.37912904
24MAP2K71.37752106
25TRPM71.37177372
26DYRK21.33560230
27MAP3K141.32308475
28TXK1.32171508
29CASK1.20690936
30CCNB11.15065928
31ERBB31.14282109
32LATS11.13035519
33GRK61.12373051
34DAPK11.09191257
35CDK191.07151280
36MINK11.04667062
37CAMK1D0.99483518
38BUB10.99395543
39MKNK20.97203538
40STK160.96030203
41VRK10.92255890
42PTK2B0.91573813
43STK390.86413451
44ALK0.85541444
45EIF2AK20.84835307
46DAPK30.83982858
47PLK30.83495614
48PHKG20.77976963
49PHKG10.77976963
50ILK0.77898217
51BMPR1B0.77828638
52NTRK10.76590764
53NLK0.74592646
54OXSR10.73859983
55AURKB0.71788772
56ITK0.71688026
57AKT20.69246829
58STK110.67822373
59INSRR0.62877644
60WNK30.59287643
61EPHA40.58400363
62STK30.56010078
63FER0.55810421
64BTK0.54467124
65DYRK30.53849685
66MAP3K110.52771546
67PRKCG0.52261934
68FES0.52118196
69TEC0.51515483
70MAP3K40.49524783
71PRKCQ0.49094151
72IKBKB0.47866071
73BRSK10.44050135
74MKNK10.42657141
75CAMKK10.42558921
76CDK80.42055631
77OBSCN0.41560100
78PLK10.41078626
79RPS6KA50.40836265
80JAK10.40742315
81NME10.38590030
82MAP3K50.36486249
83PRKG10.36346710
84GRK50.34568883
85LRRK20.33084935
86ADRBK10.32772766
87TIE10.32249946
88IGF1R0.31816664
89NEK20.31649799
90MATK0.30976527
91WNK10.30236948
92ROCK10.29729014
93SYK0.29357912
94RPS6KA40.28953051
95CAMK2A0.28117624
96AURKA0.26596526
97PRKACA0.26471188
98BCKDK0.26464386
99PLK40.25737377
100CAMK1G0.25729205

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.07403965
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005634.15297333
3Parkinsons disease_Homo sapiens_hsa050123.97304162
4Proteasome_Homo sapiens_hsa030503.89383469
5Ribosome_Homo sapiens_hsa030103.45048690
6Asthma_Homo sapiens_hsa053103.15923487
7Alzheimers disease_Homo sapiens_hsa050102.76881095
8Huntingtons disease_Homo sapiens_hsa050162.72143782
9Protein export_Homo sapiens_hsa030602.63395473
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.33825407
11Nitrogen metabolism_Homo sapiens_hsa009102.22277898
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18360786
13RNA polymerase_Homo sapiens_hsa030202.11749149
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10832842
15Cardiac muscle contraction_Homo sapiens_hsa042601.95940074
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.85359182
17Linoleic acid metabolism_Homo sapiens_hsa005911.75043509
18Homologous recombination_Homo sapiens_hsa034401.58908322
19Allograft rejection_Homo sapiens_hsa053301.57464015
20Autoimmune thyroid disease_Homo sapiens_hsa053201.51165385
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50316502
22RNA degradation_Homo sapiens_hsa030181.48859920
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.42950772
24Graft-versus-host disease_Homo sapiens_hsa053321.15799641
25Type I diabetes mellitus_Homo sapiens_hsa049401.14446984
26Collecting duct acid secretion_Homo sapiens_hsa049661.12986087
27Basal transcription factors_Homo sapiens_hsa030221.12870862
28Propanoate metabolism_Homo sapiens_hsa006401.02992021
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.02789992
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97948853
31Maturity onset diabetes of the young_Homo sapiens_hsa049500.95625261
32Primary immunodeficiency_Homo sapiens_hsa053400.95071546
33Fat digestion and absorption_Homo sapiens_hsa049750.94058139
34Peroxisome_Homo sapiens_hsa041460.93849927
35One carbon pool by folate_Homo sapiens_hsa006700.91699806
36Sulfur relay system_Homo sapiens_hsa041220.89121649
37beta-Alanine metabolism_Homo sapiens_hsa004100.87588810
38Pyrimidine metabolism_Homo sapiens_hsa002400.87292371
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87199252
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86131208
41Purine metabolism_Homo sapiens_hsa002300.79254596
42Tryptophan metabolism_Homo sapiens_hsa003800.79196660
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78562839
44Regulation of autophagy_Homo sapiens_hsa041400.78133932
45NF-kappa B signaling pathway_Homo sapiens_hsa040640.77745495
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77721891
47Arachidonic acid metabolism_Homo sapiens_hsa005900.77125520
48Ether lipid metabolism_Homo sapiens_hsa005650.75643330
49Chemical carcinogenesis_Homo sapiens_hsa052040.73765109
50Phototransduction_Homo sapiens_hsa047440.72219027
51Caffeine metabolism_Homo sapiens_hsa002320.68854187
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68429061
53Mismatch repair_Homo sapiens_hsa034300.66795917
54Metabolic pathways_Homo sapiens_hsa011000.66693419
55RNA transport_Homo sapiens_hsa030130.66358785
56Glutathione metabolism_Homo sapiens_hsa004800.66262315
57Antigen processing and presentation_Homo sapiens_hsa046120.65410768
58Folate biosynthesis_Homo sapiens_hsa007900.65303828
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65178816
60Systemic lupus erythematosus_Homo sapiens_hsa053220.64132228
61Fatty acid degradation_Homo sapiens_hsa000710.63829873
62Fanconi anemia pathway_Homo sapiens_hsa034600.63078856
63Olfactory transduction_Homo sapiens_hsa047400.60216870
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57492205
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.55691599
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55235750
67Rheumatoid arthritis_Homo sapiens_hsa053230.53479352
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52295951
69Pyruvate metabolism_Homo sapiens_hsa006200.52133301
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51172204
71Histidine metabolism_Homo sapiens_hsa003400.50404894
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50304865
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47937325
74Nucleotide excision repair_Homo sapiens_hsa034200.47478612
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.46419560
76Glycerolipid metabolism_Homo sapiens_hsa005610.45108669
77Pancreatic secretion_Homo sapiens_hsa049720.44289871
78Spliceosome_Homo sapiens_hsa030400.38741237
79T cell receptor signaling pathway_Homo sapiens_hsa046600.38234365
80Ovarian steroidogenesis_Homo sapiens_hsa049130.37284771
81Morphine addiction_Homo sapiens_hsa050320.36345605
82Epstein-Barr virus infection_Homo sapiens_hsa051690.35189757
83Selenocompound metabolism_Homo sapiens_hsa004500.35115301
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34292929
85Retinol metabolism_Homo sapiens_hsa008300.33689263
86Nicotine addiction_Homo sapiens_hsa050330.31015360
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30276232
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29294633
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28311038
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.24144911
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.22801852
92Base excision repair_Homo sapiens_hsa034100.21584343
93Starch and sucrose metabolism_Homo sapiens_hsa005000.20998293
94Measles_Homo sapiens_hsa051620.19533466
95Staphylococcus aureus infection_Homo sapiens_hsa051500.16965158
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15870012
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.15462253
98Arginine and proline metabolism_Homo sapiens_hsa003300.14983316
99Synaptic vesicle cycle_Homo sapiens_hsa047210.13757673
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.10702637

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