ATP5HP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heparin metabolic process (GO:0030202)5.09979166
2heparin biosynthetic process (GO:0030210)5.09979166
3positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)4.41436580
4regulation of B cell receptor signaling pathway (GO:0050855)4.41300265
5positive regulation of defense response to virus by host (GO:0002230)4.38433774
6leukocyte aggregation (GO:0070486)4.31192595
7glycosphingolipid biosynthetic process (GO:0006688)3.92550734
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.86541327
9hepatocyte apoptotic process (GO:0097284)3.85923586
10fucose catabolic process (GO:0019317)3.78870047
11L-fucose metabolic process (GO:0042354)3.78870047
12L-fucose catabolic process (GO:0042355)3.78870047
13regulation of telomere maintenance (GO:0032204)3.62688364
14protein K11-linked deubiquitination (GO:0035871)3.61213317
15DNA deamination (GO:0045006)3.50490205
16negative regulation of B cell proliferation (GO:0030889)3.48495052
17rRNA catabolic process (GO:0016075)3.47751674
18regulation of nuclear cell cycle DNA replication (GO:0033262)3.47365193
19RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.44817143
20epithelial cilium movement (GO:0003351)3.40906417
21behavioral response to nicotine (GO:0035095)3.33194852
22positive T cell selection (GO:0043368)3.32226979
23positive regulation of gamma-delta T cell activation (GO:0046645)3.30297816
24glycoprotein catabolic process (GO:0006516)3.24879031
25positive regulation of granulocyte differentiation (GO:0030854)3.21662099
26response to pheromone (GO:0019236)3.20130796
27myelin assembly (GO:0032288)3.13972482
28negative regulation of telomere maintenance (GO:0032205)3.09869754
29regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.04302321
30regulation of MHC class I biosynthetic process (GO:0045343)2.99952886
31reciprocal DNA recombination (GO:0035825)2.99742043
32reciprocal meiotic recombination (GO:0007131)2.99742043
33male meiosis I (GO:0007141)2.95008488
34positive regulation of signal transduction by p53 class mediator (GO:1901798)2.93798692
35meiotic chromosome segregation (GO:0045132)2.91358670
36replication fork processing (GO:0031297)2.91268303
37protein localization to vacuole (GO:0072665)2.88592561
38protein localization to lysosome (GO:0061462)2.88592561
39embryonic hemopoiesis (GO:0035162)2.87436784
40definitive hemopoiesis (GO:0060216)2.84618148
41nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.84451634
42activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.79910174
43interkinetic nuclear migration (GO:0022027)2.79872587
44negative regulation of neurotransmitter transport (GO:0051589)2.77967319
45parental behavior (GO:0060746)2.76870477
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.76503523
47I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.75496358
48positive regulation of vasculogenesis (GO:2001214)2.73419967
49rRNA transcription (GO:0009303)2.72248023
50regulation of B cell differentiation (GO:0045577)2.71409229
51forebrain morphogenesis (GO:0048853)2.69783044
52histone H3-K9 methylation (GO:0051567)2.67493359
53regulation of establishment or maintenance of cell polarity (GO:0032878)2.66653650
54organelle membrane fusion (GO:0090174)2.62930598
55regulation of gamma-delta T cell differentiation (GO:0045586)2.62451348
56phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.61715147
57cell wall macromolecule catabolic process (GO:0016998)2.59340800
58histone mRNA catabolic process (GO:0071044)2.59178908
59fibroblast migration (GO:0010761)2.58765519
60regulation of protein glycosylation (GO:0060049)2.58473273
61regulation of telomere maintenance via telomerase (GO:0032210)2.57482509
62cellular extravasation (GO:0045123)2.57372466
63negative regulation of DNA-dependent DNA replication (GO:2000104)2.57244001
64interferon-gamma production (GO:0032609)2.56931065
65negative regulation of mast cell activation (GO:0033004)2.56574581
66neural tube formation (GO:0001841)2.56563060
67negative regulation of histone acetylation (GO:0035067)2.56538407
68cellular response to interleukin-15 (GO:0071350)2.56515710
69negative regulation of neurotransmitter secretion (GO:0046929)2.56416039
70regulation of granulocyte differentiation (GO:0030852)2.55905912
71hematopoietic stem cell proliferation (GO:0071425)2.54510329
72regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)2.53675118
73N-terminal protein amino acid acetylation (GO:0006474)2.52903834
74ER overload response (GO:0006983)2.52734818
75regulation of fibroblast apoptotic process (GO:2000269)2.50571785
76positive regulation of mRNA catabolic process (GO:0061014)2.49582278
77histone H3-K9 modification (GO:0061647)2.48361627
78double-strand break repair via homologous recombination (GO:0000724)2.48060653
79regulation of triglyceride catabolic process (GO:0010896)2.47854833
80resolution of meiotic recombination intermediates (GO:0000712)2.47678855
81activation of MAPKKK activity (GO:0000185)2.47539123
82nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.47504039
83piRNA metabolic process (GO:0034587)2.45620893
84DNA methylation involved in gamete generation (GO:0043046)2.45315056
85regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.45265882
86regulation of DNA endoreduplication (GO:0032875)2.44821934
87detection of light stimulus involved in sensory perception (GO:0050962)2.43932791
88detection of light stimulus involved in visual perception (GO:0050908)2.43932791
89response to xenobiotic stimulus (GO:0009410)2.43777783
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.43392990
91indolalkylamine metabolic process (GO:0006586)2.43372100
92transepithelial transport (GO:0070633)2.43044185
93nucleus localization (GO:0051647)2.42868434
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.42672012
95positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.42259739
96regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.42259739
97regulation of chromatin silencing (GO:0031935)2.41926160
98organelle disassembly (GO:1903008)2.41899153
99positive regulation of B cell differentiation (GO:0045579)2.41460786
100recombinational repair (GO:0000725)2.40005618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.67273107
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.01928711
3ZNF274_21170338_ChIP-Seq_K562_Hela2.76371450
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.75653230
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.74502886
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52608418
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.46483889
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.44877003
9CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.44496570
10FUS_26573619_Chip-Seq_HEK293_Human2.29930531
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23979223
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.18613612
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16783308
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05162368
15ER_23166858_ChIP-Seq_MCF-7_Human2.04428180
16PCGF2_27294783_Chip-Seq_NPCs_Mouse2.02049129
17GBX2_23144817_ChIP-Seq_PC3_Human1.96893422
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94455494
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93644693
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.92039751
21TAF15_26573619_Chip-Seq_HEK293_Human1.86155675
22SUZ12_27294783_Chip-Seq_NPCs_Mouse1.84037231
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.78313067
24NFE2_27457419_Chip-Seq_LIVER_Mouse1.77834649
25TP53_16413492_ChIP-PET_HCT116_Human1.77806892
26EZH2_27294783_Chip-Seq_NPCs_Mouse1.71439718
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69649581
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65939224
29P300_19829295_ChIP-Seq_ESCs_Human1.65889291
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65653633
31EWS_26573619_Chip-Seq_HEK293_Human1.62769473
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61715825
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58434955
34CBP_20019798_ChIP-Seq_JUKART_Human1.58434955
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.58263151
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.54281112
37GATA3_26560356_Chip-Seq_TH2_Human1.52209703
38RUNX_20019798_ChIP-Seq_JUKART_Human1.50441858
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49019580
40CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.48445748
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48147896
42MYB_26560356_Chip-Seq_TH2_Human1.47612398
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45359987
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45359987
45CRX_20693478_ChIP-Seq_RETINA_Mouse1.41681845
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39499175
47ELK1_19687146_ChIP-ChIP_HELA_Human1.38456242
48TCF4_23295773_ChIP-Seq_U87_Human1.37561483
49BCAT_22108803_ChIP-Seq_LS180_Human1.36612328
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34497245
51OCT4_21477851_ChIP-Seq_ESCs_Mouse1.33799065
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33515783
53FLI1_21867929_ChIP-Seq_TH2_Mouse1.32788642
54SMAD4_21799915_ChIP-Seq_A2780_Human1.31946177
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30383945
56STAT3_23295773_ChIP-Seq_U87_Human1.29009959
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.27172274
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.26261347
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25793125
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.24488975
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.23012419
62AR_21572438_ChIP-Seq_LNCaP_Human1.20979158
63RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19767474
64SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.19504883
65STAT3_18555785_Chip-Seq_ESCs_Mouse1.19464573
66FOXP3_21729870_ChIP-Seq_TREG_Human1.19415255
67SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18565346
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18408940
69GATA3_27048872_Chip-Seq_THYMUS_Human1.18210092
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17812278
71EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17773000
72P53_22387025_ChIP-Seq_ESCs_Mouse1.16828368
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16787333
74TP53_22573176_ChIP-Seq_HFKS_Human1.15111400
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13409390
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13204738
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13152157
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11906237
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.10938423
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10385669
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.10277240
82CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10042261
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.08982465
84GATA3_21878914_ChIP-Seq_MCF-7_Human1.08774694
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08477527
86AR_25329375_ChIP-Seq_VCAP_Human1.08283686
87TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07364547
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05710163
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05345437
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.05134332
91OCT4_18555785_Chip-Seq_ESCs_Mouse1.04515845
92CIITA_25753668_ChIP-Seq_RAJI_Human1.04052625
93SMRT_27268052_Chip-Seq_Bcells_Human1.03184479
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02438079
95BRD4_25478319_ChIP-Seq_HGPS_Human1.01976062
96ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01096939
97GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00953362
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00812266
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.00173162
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00001318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.68948794
2MP0003950_abnormal_plasma_membrane4.47389619
3MP0001835_abnormal_antigen_presentation3.29409341
4MP0003786_premature_aging2.71676064
5MP0003787_abnormal_imprinting2.54788045
6MP0002102_abnormal_ear_morphology2.47712327
7MP0005671_abnormal_response_to2.47103289
8MP0000569_abnormal_digit_pigmentation2.33831118
9MP0006292_abnormal_olfactory_placode2.31953452
10MP0003806_abnormal_nucleotide_metabolis2.27950297
11MP0004043_abnormal_pH_regulation2.17543849
12MP0006072_abnormal_retinal_apoptosis2.14605170
13MP0005551_abnormal_eye_electrophysiolog1.98111555
14MP0003763_abnormal_thymus_physiology1.97959427
15MP0005623_abnormal_meninges_morphology1.93322598
16MP0008058_abnormal_DNA_repair1.82934913
17MP0003646_muscle_fatigue1.75861809
18MP0002876_abnormal_thyroid_physiology1.74015348
19MP0002090_abnormal_vision1.73192930
20MP0008961_abnormal_basal_metabolism1.68679413
21MP0005645_abnormal_hypothalamus_physiol1.68523716
22MP0004808_abnormal_hematopoietic_stem1.67802919
23MP0000427_abnormal_hair_cycle1.59438205
24MP0008877_abnormal_DNA_methylation1.57730640
25MP0008007_abnormal_cellular_replicative1.56599797
26MP0001800_abnormal_humoral_immune1.55265765
27MP0003436_decreased_susceptibility_to1.52694374
28MP0003890_abnormal_embryonic-extraembry1.46634090
29MP0000372_irregular_coat_pigmentation1.43873948
30MP0006082_CNS_inflammation1.42262742
31MP0005253_abnormal_eye_physiology1.42106620
32MP0009764_decreased_sensitivity_to1.37717063
33MP0005389_reproductive_system_phenotype1.33451724
34MP0002723_abnormal_immune_serum1.30915302
35MP0005397_hematopoietic_system_phenotyp1.30343051
36MP0001545_abnormal_hematopoietic_system1.30343051
37MP0005367_renal/urinary_system_phenotyp1.29504287
38MP0000516_abnormal_urinary_system1.29504287
39MP0003121_genomic_imprinting1.22815920
40MP0010307_abnormal_tumor_latency1.22423033
41MP0002405_respiratory_system_inflammati1.22133411
42MP0008872_abnormal_physiological_respon1.21426013
43MP0002166_altered_tumor_susceptibility1.16633051
44MP0003045_fibrosis1.16200448
45MP0000750_abnormal_muscle_regeneration1.15820494
46MP0002420_abnormal_adaptive_immunity1.13642227
47MP0002933_joint_inflammation1.13479420
48MP0005000_abnormal_immune_tolerance1.13066178
49MP0009785_altered_susceptibility_to1.12116650
50MP0009697_abnormal_copulation1.12045389
51MP0005266_abnormal_metabolism1.09445443
52MP0003943_abnormal_hepatobiliary_system1.09243174
53MP0001819_abnormal_immune_cell1.07585395
54MP0001919_abnormal_reproductive_system1.07168050
55MP0002452_abnormal_antigen_presenting1.06957452
56MP0000703_abnormal_thymus_morphology1.06573152
57MP0002638_abnormal_pupillary_reflex1.06287629
58MP0004134_abnormal_chest_morphology1.04342742
59MP0010386_abnormal_urinary_bladder1.03845285
60MP0002396_abnormal_hematopoietic_system1.02890918
61MP0000689_abnormal_spleen_morphology1.00958404
62MP0000716_abnormal_immune_system1.00355558
63MP0001542_abnormal_bone_strength1.00328251
64MP0002398_abnormal_bone_marrow1.00046265
65MP0001853_heart_inflammation0.98064519
66MP0002160_abnormal_reproductive_system0.97363333
67MP0002332_abnormal_exercise_endurance0.97218069
68MP0004084_abnormal_cardiac_muscle0.94011207
69MP0000013_abnormal_adipose_tissue0.90433672
70MP0009115_abnormal_fat_cell0.88387016
71MP0004883_abnormal_blood_vessel0.88367697
72MP0005025_abnormal_response_to0.86386077
73MP0004484_altered_response_of0.85105191
74MP0001501_abnormal_sleep_pattern0.84879923
75MP0003252_abnormal_bile_duct0.83990772
76MP0001873_stomach_inflammation0.81910910
77MP0002722_abnormal_immune_system0.77651242
78MP0004142_abnormal_muscle_tone0.76886583
79MP0003011_delayed_dark_adaptation0.76779924
80MP0003866_abnormal_defecation0.76185487
81MP0000685_abnormal_immune_system0.75834620
82MP0002148_abnormal_hypersensitivity_rea0.75686531
83MP0005365_abnormal_bile_salt0.75339332
84MP0005646_abnormal_pituitary_gland0.74911811
85MP0002429_abnormal_blood_cell0.73926115
86MP0002254_reproductive_system_inflammat0.73876842
87MP0001440_abnormal_grooming_behavior0.71948698
88MP0000383_abnormal_hair_follicle0.70787297
89MP0003656_abnormal_erythrocyte_physiolo0.68715994
90MP0002419_abnormal_innate_immunity0.68501496
91MP0001986_abnormal_taste_sensitivity0.68352683
92MP0005376_homeostasis/metabolism_phenot0.68191368
93MP0008775_abnormal_heart_ventricle0.68173564
94MP0005275_abnormal_skin_tensile0.67675382
95MP0005084_abnormal_gallbladder_morpholo0.67615475
96MP0002938_white_spotting0.66907674
97MP0002928_abnormal_bile_duct0.66119414
98MP0003828_pulmonary_edema0.66024532
99MP0005164_abnormal_response_to0.64889308
100MP0002168_other_aberrant_phenotype0.62856367

Predicted human phenotypes

RankGene SetZ-score
1Cerebellar dysplasia (HP:0007033)5.33216741
2Type II lissencephaly (HP:0007260)5.02869931
3Retinal atrophy (HP:0001105)4.45875413
4Abnormality of the pons (HP:0007361)4.32770644
5Hypoplasia of the pons (HP:0012110)4.31699094
6Chronic hepatic failure (HP:0100626)4.24701309
7Decreased electroretinogram (ERG) amplitude (HP:0000654)4.17493168
8Pancreatic cysts (HP:0001737)4.15467228
9Retinal dysplasia (HP:0007973)3.84768397
10Volvulus (HP:0002580)3.74802282
11Pancreatic fibrosis (HP:0100732)3.69598106
12Fatigue (HP:0012378)3.60680711
13True hermaphroditism (HP:0010459)3.59564115
14Abolished electroretinogram (ERG) (HP:0000550)3.49612338
15Molar tooth sign on MRI (HP:0002419)3.48907966
16Abnormality of midbrain morphology (HP:0002418)3.48907966
17Buphthalmos (HP:0000557)3.18659097
18Submucous cleft hard palate (HP:0000176)3.16637635
19Aplasia/Hypoplasia affecting the retina (HP:0008061)3.13960276
20Absent rod-and cone-mediated responses on ERG (HP:0007688)3.05481722
21Stomatitis (HP:0010280)3.04221286
22Aplasia/Hypoplasia of the spleen (HP:0010451)3.01850629
23Tubular atrophy (HP:0000092)3.00368413
24Asplenia (HP:0001746)2.99551665
25Nephronophthisis (HP:0000090)2.89548196
26Acute myeloid leukemia (HP:0004808)2.89293033
27Elevated erythrocyte sedimentation rate (HP:0003565)2.84287465
28Lissencephaly (HP:0001339)2.80468415
29Cystic liver disease (HP:0006706)2.72092208
30Thyroiditis (HP:0100646)2.70181583
31Abnormality of the renal medulla (HP:0100957)2.66383993
32Metaphyseal dysplasia (HP:0100255)2.63615334
33Severe muscular hypotonia (HP:0006829)2.62171713
34Attenuation of retinal blood vessels (HP:0007843)2.60654371
35Abnormality of the renal cortex (HP:0011035)2.51566281
36Dyschromatopsia (HP:0007641)2.45892424
37Abnormal rod and cone electroretinograms (HP:0008323)2.42470917
38Pachygyria (HP:0001302)2.42178039
39Abnormal drinking behavior (HP:0030082)2.34779079
40Polydipsia (HP:0001959)2.34779079
41Widely spaced teeth (HP:0000687)2.33350692
42T lymphocytopenia (HP:0005403)2.32141355
43Stomach cancer (HP:0012126)2.31869844
44Neoplasm of the tracheobronchial system (HP:0100552)2.25605685
45IgG deficiency (HP:0004315)2.22089118
46Increased corneal curvature (HP:0100692)2.22004402
47Keratoconus (HP:0000563)2.22004402
48Concave nail (HP:0001598)2.12310883
49Abnormality of T cell number (HP:0011839)2.11747583
50Keratitis (HP:0000491)2.07389367
51Supernumerary spleens (HP:0009799)2.07311223
52Megalocornea (HP:0000485)2.06897002
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.06681543
54Abnormality of DNA repair (HP:0003254)2.04724908
55Abnormality of B cell number (HP:0010975)2.03554889
56Alveolar cell carcinoma (HP:0006519)2.03174423
57Aqueductal stenosis (HP:0002410)2.03056964
58Congenital hepatic fibrosis (HP:0002612)2.01510732
59Hypoplasia of the thymus (HP:0000778)2.00251177
60Tented upper lip vermilion (HP:0010804)1.99152430
61Acute hepatic failure (HP:0006554)1.98998082
62Gastrointestinal infarctions (HP:0005244)1.98305086
63Occipital encephalocele (HP:0002085)1.98233410
64Dandy-Walker malformation (HP:0001305)1.97348866
65Anencephaly (HP:0002323)1.95527945
66Furrowed tongue (HP:0000221)1.91966793
67Congenital stationary night blindness (HP:0007642)1.91905012
68Medial flaring of the eyebrow (HP:0010747)1.90895115
69Recurrent fungal infections (HP:0002841)1.89182952
70Clubbing of toes (HP:0100760)1.88337531
71B lymphocytopenia (HP:0010976)1.86696761
72Hyperventilation (HP:0002883)1.84917861
73Dynein arm defect of respiratory motile cilia (HP:0012255)1.84462374
74Absent/shortened dynein arms (HP:0200106)1.84462374
75Abnormal biliary tract physiology (HP:0012439)1.83790243
76Bile duct proliferation (HP:0001408)1.83790243
77Sloping forehead (HP:0000340)1.81797296
78Myelodysplasia (HP:0002863)1.79707750
79Chronic mucocutaneous candidiasis (HP:0002728)1.79598165
80Recurrent cutaneous fungal infections (HP:0011370)1.79598165
81Spondylolisthesis (HP:0003302)1.78732167
82Absent frontal sinuses (HP:0002688)1.74487563
83Neuroendocrine neoplasm (HP:0100634)1.72794378
84Hypoplastic iliac wings (HP:0002866)1.71973408
85Abnormality of the labia minora (HP:0012880)1.69883499
86Eosinophilia (HP:0001880)1.69751104
87Decreased central vision (HP:0007663)1.68115086
88Abnormality of the phalanges of the 2nd finger (HP:0009541)1.66124007
89Aplasia/Hypoplasia of the uvula (HP:0010293)1.65821160
90Abnormality of chromosome stability (HP:0003220)1.65241646
91Panhypogammaglobulinemia (HP:0003139)1.64172876
92Highly arched eyebrow (HP:0002553)1.63426692
93Abnormality of incisor morphology (HP:0011063)1.62740876
94Leukocytosis (HP:0001974)1.61268735
95Macular degeneration (HP:0000608)1.61196521
96Progressive macrocephaly (HP:0004481)1.60641781
97Keratoconjunctivitis (HP:0001096)1.60071519
98Papilledema (HP:0001085)1.60060383
99Sclerocornea (HP:0000647)1.59342395
100Bulbous nose (HP:0000414)1.58567043

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.12120206
2MARK33.16905402
3FLT32.86046437
4MAP4K22.71005627
5STK102.68847037
6AKT32.58465859
7MKNK22.55013201
8WNK32.47634199
9ADRBK22.44190951
10ZAK2.34978755
11TAOK32.19099406
12PIK3CG2.15522025
13EIF2AK32.13129683
14TXK2.05080620
15PINK12.00605936
16NUAK11.97111000
17SIK31.95151201
18GRK71.79834990
19BRD41.73675529
20MAP3K31.63204774
21PTK2B1.52612407
22TRIM281.52453794
23ACVR1B1.44396352
24TYK21.43672299
25WNK41.43492024
26IRAK11.43334503
27CCNB11.35619079
28PIM11.28836079
29JAK11.24459805
30MAP4K11.22449386
31VRK21.21728342
32BMPR1B1.16799676
33IKBKB1.16668010
34SGK31.12799008
35KIT1.11253250
36GRK11.11108056
37SGK21.09770010
38NLK1.09644726
39STK391.09442340
40PAK31.09247019
41MAP3K121.08422892
42VRK11.07204202
43TRPM71.02294579
44PRKCE1.00988938
45TEC0.98702497
46EPHA40.96470928
47STK110.94890281
48BMPR20.92157807
49MKNK10.86929617
50FES0.86279885
51HIPK20.84925899
52CLK10.84691712
53MAPK130.82940732
54CSF1R0.79431115
55MAP2K30.76414982
56TNIK0.75066832
57PRKCQ0.72597646
58OXSR10.72345201
59SYK0.70521798
60WNK10.70410926
61PRKCH0.70123747
62EIF2AK20.67861859
63LCK0.67293371
64IRAK20.66024293
65IKBKE0.64990909
66CAMK1G0.63992479
67STK30.62957057
68INSRR0.57536840
69RIPK40.57257163
70MAP3K40.55145104
71MAP3K140.54415466
72HCK0.53843487
73PIK3CA0.51751896
74MELK0.51245890
75SGK10.51133010
76DYRK1A0.50759992
77LYN0.50254500
78ITK0.49803090
79SIK20.49560645
80BTK0.46723877
81BRSK20.44258176
82ATR0.43200879
83PLK20.41620353
84CSK0.41350521
85ZAP700.41065428
86RPS6KB20.40036851
87FGFR20.39436698
88EPHB10.39264285
89ERBB30.37761166
90PKN10.37516891
91CAMK1D0.36541218
92IRAK40.36240348
93TAF10.36106677
94SGK2230.34897988
95SGK4940.34897988
96PRKAA10.34851973
97ABL10.33812566
98CAMK10.33547665
99CSNK1G10.31877110
100ADRBK10.28381225

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.40728704
2Primary immunodeficiency_Homo sapiens_hsa053402.88938493
3Graft-versus-host disease_Homo sapiens_hsa053322.84016811
4Allograft rejection_Homo sapiens_hsa053302.80620250
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.69178899
6Autoimmune thyroid disease_Homo sapiens_hsa053202.60963289
7SNARE interactions in vesicular transport_Homo sapiens_hsa041302.60011437
8Leishmaniasis_Homo sapiens_hsa051402.25024604
9Type I diabetes mellitus_Homo sapiens_hsa049402.19253795
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11708841
11Phototransduction_Homo sapiens_hsa047442.03398696
12Non-homologous end-joining_Homo sapiens_hsa034501.77527045
13Fanconi anemia pathway_Homo sapiens_hsa034601.74989867
14Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.74221981
15Antigen processing and presentation_Homo sapiens_hsa046121.71590097
16Osteoclast differentiation_Homo sapiens_hsa043801.64649033
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61755583
18Basal transcription factors_Homo sapiens_hsa030221.61236007
19Staphylococcus aureus infection_Homo sapiens_hsa051501.59709063
20Hematopoietic cell lineage_Homo sapiens_hsa046401.54465916
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.51412143
22Ether lipid metabolism_Homo sapiens_hsa005651.50771988
23Toxoplasmosis_Homo sapiens_hsa051451.40905666
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40528790
25RNA polymerase_Homo sapiens_hsa030201.39091880
26Herpes simplex infection_Homo sapiens_hsa051681.33900076
27Dorso-ventral axis formation_Homo sapiens_hsa043201.33091093
28Linoleic acid metabolism_Homo sapiens_hsa005911.28992768
29Legionellosis_Homo sapiens_hsa051341.27180222
30Viral myocarditis_Homo sapiens_hsa054161.23877315
31TNF signaling pathway_Homo sapiens_hsa046681.23524513
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23023714
33Rheumatoid arthritis_Homo sapiens_hsa053231.21940202
34RNA degradation_Homo sapiens_hsa030181.20987975
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20272371
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14221240
37Nitrogen metabolism_Homo sapiens_hsa009101.13909873
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11699284
39Homologous recombination_Homo sapiens_hsa034401.09252771
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.08550344
41T cell receptor signaling pathway_Homo sapiens_hsa046601.03612020
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03151457
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02726902
44Sphingolipid metabolism_Homo sapiens_hsa006001.01318231
45Nucleotide excision repair_Homo sapiens_hsa034200.97884636
46Collecting duct acid secretion_Homo sapiens_hsa049660.95910578
47Inositol phosphate metabolism_Homo sapiens_hsa005620.95148067
48Olfactory transduction_Homo sapiens_hsa047400.93567799
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89074526
50Measles_Homo sapiens_hsa051620.88447622
51Influenza A_Homo sapiens_hsa051640.81778470
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80884222
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78716994
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77705707
55Salivary secretion_Homo sapiens_hsa049700.73369002
56Platelet activation_Homo sapiens_hsa046110.73186661
57Tuberculosis_Homo sapiens_hsa051520.72845359
58Taste transduction_Homo sapiens_hsa047420.70018234
59p53 signaling pathway_Homo sapiens_hsa041150.69546991
60Selenocompound metabolism_Homo sapiens_hsa004500.69479840
61Systemic lupus erythematosus_Homo sapiens_hsa053220.69173048
62Epstein-Barr virus infection_Homo sapiens_hsa051690.67857142
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66195908
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61186797
65Regulation of autophagy_Homo sapiens_hsa041400.60816176
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60361584
67Butanoate metabolism_Homo sapiens_hsa006500.58617762
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58131625
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56183796
70Oxidative phosphorylation_Homo sapiens_hsa001900.53322387
71Protein export_Homo sapiens_hsa030600.53024610
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52404863
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50792648
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48836268
75Chemokine signaling pathway_Homo sapiens_hsa040620.48107867
76Lysine degradation_Homo sapiens_hsa003100.47957360
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.46905854
78Base excision repair_Homo sapiens_hsa034100.44811868
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44485685
80Cholinergic synapse_Homo sapiens_hsa047250.43922612
81One carbon pool by folate_Homo sapiens_hsa006700.43492771
82Huntingtons disease_Homo sapiens_hsa050160.43229606
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42536106
84Long-term depression_Homo sapiens_hsa047300.42320626
85Phagosome_Homo sapiens_hsa041450.40010407
86Pancreatic secretion_Homo sapiens_hsa049720.38704675
87Calcium signaling pathway_Homo sapiens_hsa040200.37950448
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37797272
89Chemical carcinogenesis_Homo sapiens_hsa052040.36718575
90Hepatitis B_Homo sapiens_hsa051610.36296357
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36279895
92African trypanosomiasis_Homo sapiens_hsa051430.35017306
93FoxO signaling pathway_Homo sapiens_hsa040680.33373116
94Arachidonic acid metabolism_Homo sapiens_hsa005900.32733761
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32128882
96Proteasome_Homo sapiens_hsa030500.31340365
97Serotonergic synapse_Homo sapiens_hsa047260.31248710
98Circadian rhythm_Homo sapiens_hsa047100.30528519
99MAPK signaling pathway_Homo sapiens_hsa040100.30356741
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.27488152

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