ATP5J

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo complex has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the Fo complex. The F6 subunit is required for F1 and Fo interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has 1 or more pseudogenes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.52254018
2* respiratory electron transport chain (GO:0022904)8.70909149
3* electron transport chain (GO:0022900)8.49226856
4chaperone-mediated protein transport (GO:0072321)5.86552235
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.69253093
6mitochondrial respiratory chain complex I assembly (GO:0032981)5.65561713
7NADH dehydrogenase complex assembly (GO:0010257)5.65561713
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.65561713
9protein complex biogenesis (GO:0070271)5.55035119
10oxidative phosphorylation (GO:0006119)5.53008956
11* ATP biosynthetic process (GO:0006754)5.44949320
12* hydrogen ion transmembrane transport (GO:1902600)5.15894985
13* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.14162423
14mitochondrial respiratory chain complex assembly (GO:0033108)5.09016783
15* purine nucleoside triphosphate biosynthetic process (GO:0009145)5.07814204
16inner mitochondrial membrane organization (GO:0007007)5.02226009
17protein neddylation (GO:0045116)4.76214458
18* proton transport (GO:0015992)4.51705456
19* ribonucleoside triphosphate biosynthetic process (GO:0009201)4.49091140
20ribosomal large subunit biogenesis (GO:0042273)4.45879295
21* hydrogen transport (GO:0006818)4.43686691
22regulation of mitochondrial translation (GO:0070129)4.19762392
23GTP biosynthetic process (GO:0006183)4.09486974
24ribosomal small subunit biogenesis (GO:0042274)4.07967300
25tricarboxylic acid cycle (GO:0006099)4.02533130
26aerobic respiration (GO:0009060)4.00883299
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.97987016
28viral transcription (GO:0019083)3.95893228
29regulation of oxidative phosphorylation (GO:0002082)3.95276076
30* nucleoside triphosphate biosynthetic process (GO:0009142)3.90571514
31translational termination (GO:0006415)3.82500088
32protein targeting to mitochondrion (GO:0006626)3.70788111
33respiratory chain complex IV assembly (GO:0008535)3.69373200
34cotranslational protein targeting to membrane (GO:0006613)3.68401622
35proteasome assembly (GO:0043248)3.68371150
36establishment of protein localization to mitochondrion (GO:0072655)3.68020958
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.64303191
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.61711032
39* mitochondrial transport (GO:0006839)3.60084732
40protein targeting to ER (GO:0045047)3.59421617
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.58248825
42regulation of cellular respiration (GO:0043457)3.57952916
43exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.57814654
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.57734610
45cellular component biogenesis (GO:0044085)3.56226812
46energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.51848137
47ATP hydrolysis coupled proton transport (GO:0015991)3.51848137
48protein localization to mitochondrion (GO:0070585)3.49236473
49protein complex disassembly (GO:0043241)3.48056312
50protein localization to endoplasmic reticulum (GO:0070972)3.47558921
51rRNA modification (GO:0000154)3.46344910
52establishment of protein localization to endoplasmic reticulum (GO:0072599)3.45070575
53NADH metabolic process (GO:0006734)3.42475050
54macromolecular complex disassembly (GO:0032984)3.41430017
55anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.40719940
56dopamine transport (GO:0015872)3.40538282
57UTP biosynthetic process (GO:0006228)3.35938284
58succinate metabolic process (GO:0006105)3.35226426
59protein targeting to membrane (GO:0006612)3.34020567
60ubiquinone biosynthetic process (GO:0006744)3.29680491
61quinone biosynthetic process (GO:1901663)3.29680491
62* purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.29596255
63* purine nucleoside monophosphate biosynthetic process (GO:0009127)3.29596255
64signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.29262080
65signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.29262080
66signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.29262080
67intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.28078460
68signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.28078460
69cytochrome complex assembly (GO:0017004)3.27852728
70regulation of cellular amino acid metabolic process (GO:0006521)3.26981044
71translational elongation (GO:0006414)3.20537410
72cellular respiration (GO:0045333)3.20427478
73intracellular protein transmembrane import (GO:0044743)3.18480392
74positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.17969871
75* generation of precursor metabolites and energy (GO:0006091)3.17915964
76signal transduction involved in DNA damage checkpoint (GO:0072422)3.15770675
77signal transduction involved in DNA integrity checkpoint (GO:0072401)3.15770675
78guanosine-containing compound biosynthetic process (GO:1901070)3.14953830
79CENP-A containing nucleosome assembly (GO:0034080)3.14812730
80chromatin remodeling at centromere (GO:0031055)3.13926107
81signal transduction involved in cell cycle checkpoint (GO:0072395)3.13138704
82spliceosomal snRNP assembly (GO:0000387)3.12716098
83DNA damage response, detection of DNA damage (GO:0042769)3.12536625
84ribonucleoprotein complex biogenesis (GO:0022613)3.11009148
85water-soluble vitamin biosynthetic process (GO:0042364)3.09984794
86cellular protein complex disassembly (GO:0043624)3.09675978
87UTP metabolic process (GO:0046051)3.07797825
88translation (GO:0006412)3.06466328
89cullin deneddylation (GO:0010388)3.06324668
90ribosomal small subunit assembly (GO:0000028)3.06153812
91pseudouridine synthesis (GO:0001522)3.05051565
92ubiquinone metabolic process (GO:0006743)3.04644568
93tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.03828616
94RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.03828616
95nuclear-transcribed mRNA catabolic process (GO:0000956)3.03436359
96positive regulation of ligase activity (GO:0051351)3.02750274
97protein-cofactor linkage (GO:0018065)3.02256616
98deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.01615058
99viral life cycle (GO:0019058)2.99928212
100organelle disassembly (GO:1903008)2.97048321
101rRNA processing (GO:0006364)2.96516396
102regulation of acyl-CoA biosynthetic process (GO:0050812)2.95659115
103* purine nucleoside biosynthetic process (GO:0042451)2.95164228
104* purine ribonucleoside biosynthetic process (GO:0046129)2.95164228
105negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91281377
106L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.86731441
107sequestering of actin monomers (GO:0042989)2.86287379
108negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.85788012
109rRNA metabolic process (GO:0016072)2.85054607
110mRNA catabolic process (GO:0006402)2.84594338
1117-methylguanosine mRNA capping (GO:0006370)2.83359470
112transcription elongation from RNA polymerase III promoter (GO:0006385)2.82900011
113termination of RNA polymerase III transcription (GO:0006386)2.82900011
114protein deneddylation (GO:0000338)2.82200752
115fatty acid elongation (GO:0030497)2.79841017
116nucleoside diphosphate phosphorylation (GO:0006165)2.79798092
117CTP biosynthetic process (GO:0006241)2.76909826
118CTP metabolic process (GO:0046036)2.76909826
119heart contraction (GO:0060047)2.75838461
120heart process (GO:0003015)2.75838461
121regulation of coenzyme metabolic process (GO:0051196)2.74615610
122regulation of cofactor metabolic process (GO:0051193)2.74615610
123establishment of integrated proviral latency (GO:0075713)2.71619254
124regulation of cellular amine metabolic process (GO:0033238)2.69940438
125negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.69520081
126negative regulation of ligase activity (GO:0051352)2.69520081
127mitochondrion morphogenesis (GO:0070584)2.68339378
128maturation of SSU-rRNA (GO:0030490)2.67811074
129positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.67694549
130antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.66722070
131DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.63752940
132* ribonucleoside monophosphate biosynthetic process (GO:0009156)2.63463546
133* substantia nigra development (GO:0021762)2.62798236
134translational initiation (GO:0006413)2.60898061
135regulation of cell communication by electrical coupling (GO:0010649)2.60773576
136regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.59380834
137* mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.8811581
138* energy coupled proton transport, down electrochemical gradient (GO:0015985)10.2604694
139* ATP synthesis coupled proton transport (GO:0015986)10.2604694

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.68038606
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.43762291
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.89183055
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.84809579
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.59031913
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.57100374
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.20173058
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94625407
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.92170535
10ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.91909511
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.91053067
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88557787
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77661812
14EZH2_22144423_ChIP-Seq_EOC_Human2.69106284
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.64157343
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.57073347
17VDR_22108803_ChIP-Seq_LS180_Human2.51978358
18TAF15_26573619_Chip-Seq_HEK293_Human2.27525646
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20373169
20* SRF_21415370_ChIP-Seq_HL-1_Mouse2.18831706
21* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12119427
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.10872110
23* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81814074
24* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77696365
25CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.74090000
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.73661199
27DCP1A_22483619_ChIP-Seq_HELA_Human1.71846570
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.69565838
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67778775
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66309136
31ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59702289
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59301264
33VDR_23849224_ChIP-Seq_CD4+_Human1.57988163
34FUS_26573619_Chip-Seq_HEK293_Human1.57959520
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.55749694
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55689682
37GBX2_23144817_ChIP-Seq_PC3_Human1.54599886
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53796639
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53431795
40ELK1_19687146_ChIP-ChIP_HELA_Human1.51724191
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51385825
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45264942
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43854781
44ELK1_22589737_ChIP-Seq_MCF10A_Human1.42890102
45E2F7_22180533_ChIP-Seq_HELA_Human1.40518414
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32150563
47TTF2_22483619_ChIP-Seq_HELA_Human1.31651577
48IRF1_19129219_ChIP-ChIP_H3396_Human1.30337493
49HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28988163
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27931748
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27423136
52FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.25883423
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23650954
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22267588
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21391907
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21339113
57HTT_18923047_ChIP-ChIP_STHdh_Human1.21045674
58* FOXP3_21729870_ChIP-Seq_TREG_Human1.20880065
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19565835
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18976317
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.18424261
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18282847
63SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17090570
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15830282
65* XRN2_22483619_ChIP-Seq_HELA_Human1.15679213
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12636287
67ER_23166858_ChIP-Seq_MCF-7_Human1.12379944
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.10943948
69* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08526418
70CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07659740
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06727040
72MYC_18940864_ChIP-ChIP_HL60_Human1.05068401
73CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04429260
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04028764
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03855549
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03136900
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01282545
78* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01277325
79TP53_22573176_ChIP-Seq_HFKS_Human0.99229214
80ZNF274_21170338_ChIP-Seq_K562_Hela0.98615384
81MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98602975
82* P300_19829295_ChIP-Seq_ESCs_Human0.97567175
83* GABP_19822575_ChIP-Seq_HepG2_Human0.96647266
84EED_16625203_ChIP-ChIP_MESCs_Mouse0.96635866
85SOX2_16153702_ChIP-ChIP_HESCs_Human0.96227787
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96188160
87NANOG_16153702_ChIP-ChIP_HESCs_Human0.95430315
88JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95171912
89IGF1R_20145208_ChIP-Seq_DFB_Human0.94691414
90POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93478037
91SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93187091
92PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92628343
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92125530
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91814867
95SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90888575
96* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90528922
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89102712
98ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88421689
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88232253
100* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87756706
101REST_21632747_ChIP-Seq_MESCs_Mouse0.87388679
102NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87327780
103SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86748771
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86389139
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85904824
106PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85005670
107E2F1_21310950_ChIP-Seq_MCF-7_Human0.84792167
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83789832
109HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83501260
110REST_19997604_ChIP-ChIP_NEURONS_Mouse0.83227083
111KDM5A_27292631_Chip-Seq_BREAST_Human0.82543422
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81907532
113REST_18959480_ChIP-ChIP_MESCs_Mouse0.80843228
114TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80615566
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80590763
116PADI4_21655091_ChIP-ChIP_MCF-7_Human0.80018052
117EWS_26573619_Chip-Seq_HEK293_Human0.79915256
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.79624560
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78844813
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78677045
121JUN_21703547_ChIP-Seq_K562_Human0.77314941
122FLI1_27457419_Chip-Seq_LIVER_Mouse0.77085617
123SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.77010350
124* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76711420
125ZFX_18555785_ChIP-Seq_MESCs_Mouse0.76343829
126SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.75234354
127AR_21909140_ChIP-Seq_LNCAP_Human0.73390126
128* ERG_20517297_ChIP-Seq_VCAP_Human0.72707406
129FOXA1_25329375_ChIP-Seq_VCAP_Human0.72584192
130FOXA1_27270436_Chip-Seq_PROSTATE_Human0.72584192
131AR_20517297_ChIP-Seq_VCAP_Human0.72349064
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.70571356

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.34991340
2MP0003880_abnormal_central_pattern4.07705353
3MP0001529_abnormal_vocalization3.80516110
4MP0009379_abnormal_foot_pigmentation3.24774042
5MP0006036_abnormal_mitochondrial_physio3.05252862
6MP0004215_abnormal_myocardial_fiber2.87398354
7MP0003646_muscle_fatigue2.71896977
8MP0000751_myopathy2.69774818
9MP0001905_abnormal_dopamine_level2.69579542
10MP0006276_abnormal_autonomic_nervous2.61965081
11MP0006035_abnormal_mitochondrial_morpho2.55928229
12MP0008058_abnormal_DNA_repair2.50114130
13MP0006292_abnormal_olfactory_placode2.40549466
14MP0004036_abnormal_muscle_relaxation2.36622812
15MP0002938_white_spotting2.29820214
16MP0000749_muscle_degeneration2.27126826
17MP0004084_abnormal_cardiac_muscle2.19595956
18MP0004142_abnormal_muscle_tone2.17090573
19MP0003011_delayed_dark_adaptation2.11186416
20MP0002736_abnormal_nociception_after2.01397226
21MP0003806_abnormal_nucleotide_metabolis2.01175485
22MP0004145_abnormal_muscle_electrophysio2.01035010
23MP0003718_maternal_effect1.97858789
24MP0005330_cardiomyopathy1.95039341
25MP0004957_abnormal_blastocyst_morpholog1.88237089
26MP0009046_muscle_twitch1.83253184
27MP0001440_abnormal_grooming_behavior1.81860945
28MP0009745_abnormal_behavioral_response1.81347800
29MP0001968_abnormal_touch/_nociception1.79753745
30MP0002272_abnormal_nervous_system1.79682439
31MP0003693_abnormal_embryo_hatching1.74547439
32MP0002064_seizures1.74326651
33MP0003137_abnormal_impulse_conducting1.73317124
34MP0002102_abnormal_ear_morphology1.71180217
35MP0009697_abnormal_copulation1.68194736
36MP0002822_catalepsy1.62926268
37MP0010094_abnormal_chromosome_stability1.57080902
38MP0003786_premature_aging1.54123098
39MP0002638_abnormal_pupillary_reflex1.53874761
40MP0001984_abnormal_olfaction1.52395002
41MP0005408_hypopigmentation1.51659543
42MP0008995_early_reproductive_senescence1.50578088
43MP0003635_abnormal_synaptic_transmissio1.49476744
44MP0002735_abnormal_chemical_nociception1.48514062
45MP0008789_abnormal_olfactory_epithelium1.48348879
46MP0002332_abnormal_exercise_endurance1.47849789
47MP0002972_abnormal_cardiac_muscle1.45931380
48MP0005386_behavior/neurological_phenoty1.42964832
49MP0004924_abnormal_behavior1.42964832
50MP0004043_abnormal_pH_regulation1.42462510
51MP0004484_altered_response_of1.42309317
52MP0002572_abnormal_emotion/affect_behav1.39593079
53MP0005620_abnormal_muscle_contractility1.39324090
54MP0002734_abnormal_mechanical_nocicepti1.36973879
55MP0008932_abnormal_embryonic_tissue1.33840673
56MP0008877_abnormal_DNA_methylation1.33004307
57MP0001486_abnormal_startle_reflex1.32261974
58MP0004085_abnormal_heartbeat1.31784866
59MP0004147_increased_porphyrin_level1.27805330
60MP0001485_abnormal_pinna_reflex1.25655733
61MP0002876_abnormal_thyroid_physiology1.25457302
62MP0000747_muscle_weakness1.25074188
63MP0002106_abnormal_muscle_physiology1.24650052
64MP0002067_abnormal_sensory_capabilities1.24444174
65MP0005379_endocrine/exocrine_gland_phen1.21593916
66MP0003122_maternal_imprinting1.20339421
67MP0003195_calcinosis1.20259494
68MP0001501_abnormal_sleep_pattern1.19149470
69MP0003186_abnormal_redox_activity1.18584386
70MP0005253_abnormal_eye_physiology1.18497278
71MP0005646_abnormal_pituitary_gland1.18020810
72MP0001970_abnormal_pain_threshold1.16996226
73MP0002163_abnormal_gland_morphology1.15040082
74MP0001727_abnormal_embryo_implantation1.13782525
75MP0005266_abnormal_metabolism1.13235790
76MP0002160_abnormal_reproductive_system1.13097762
77MP0010030_abnormal_orbit_morphology1.11465011
78MP0001293_anophthalmia1.11238103
79MP0002063_abnormal_learning/memory/cond1.10960733
80MP0003077_abnormal_cell_cycle1.10944687
81MP0004270_analgesia1.08332953
82MP0005645_abnormal_hypothalamus_physiol1.08186431
83MP0008875_abnormal_xenobiotic_pharmacok1.07912420
84MP0002277_abnormal_respiratory_mucosa1.07008885
85MP0006072_abnormal_retinal_apoptosis1.06920507
86MP0008775_abnormal_heart_ventricle1.06879749
87MP0000631_abnormal_neuroendocrine_gland1.05552794
88MP0005332_abnormal_amino_acid1.05231617
89MP0005636_abnormal_mineral_homeostasis1.05169553
90MP0008872_abnormal_physiological_respon1.04560080
91MP0005423_abnormal_somatic_nervous1.04368077
92MP0003111_abnormal_nucleus_morphology1.03516967
93MP0005369_muscle_phenotype1.02998122
94MP0001544_abnormal_cardiovascular_syste1.02464872
95MP0005385_cardiovascular_system_phenoty1.02464872
96MP0005535_abnormal_body_temperature1.01757065
97MP0000750_abnormal_muscle_regeneration1.01631622
98MP0002095_abnormal_skin_pigmentation1.00628470
99MP0003567_abnormal_fetal_cardiomyocyte0.99268232
100MP0003136_yellow_coat_color0.98601330
101MP0002139_abnormal_hepatobiliary_system0.98007676
102MP0002733_abnormal_thermal_nociception0.97797900
103MP0001188_hyperpigmentation0.96013288
104MP0002234_abnormal_pharynx_morphology0.95652520
105MP0005670_abnormal_white_adipose0.95010509
106MP0000230_abnormal_systemic_arterial0.94698255
107MP0005551_abnormal_eye_electrophysiolog0.94253281
108MP0003329_amyloid_beta_deposits0.93630540
109MP0006138_congestive_heart_failure0.92933251
110MP0003121_genomic_imprinting0.92682069
111MP0005083_abnormal_biliary_tract0.92396510
112MP0002090_abnormal_vision0.91000050
113MP0000372_irregular_coat_pigmentation0.90525189
114MP0005389_reproductive_system_phenotype0.89767586
115MP0010386_abnormal_urinary_bladder0.89511463
116MP0004087_abnormal_muscle_fiber0.89144596
117MP0005499_abnormal_olfactory_system0.88038506
118MP0005394_taste/olfaction_phenotype0.88038506
119MP0002210_abnormal_sex_determination0.87846049
120MP0005084_abnormal_gallbladder_morpholo0.87091103
121MP0002127_abnormal_cardiovascular_syste0.86267855
122MP0000013_abnormal_adipose_tissue0.86094861
123MP0005409_darkened_coat_color0.85715912
124MP0003221_abnormal_cardiomyocyte_apopto0.84887899
125MP0002184_abnormal_innervation0.84785978
126MP0004742_abnormal_vestibular_system0.83126778
127MP0005451_abnormal_body_composition0.82906107
128MP0003950_abnormal_plasma_membrane0.82524755
129MP0003123_paternal_imprinting0.81251345
130MP0001764_abnormal_homeostasis0.81229549
131MP0002066_abnormal_motor_capabilities/c0.80569320
132MP0005376_homeostasis/metabolism_phenot0.78492885
133MP0002229_neurodegeneration0.77936023
134MP0005165_increased_susceptibility_to0.77735325
135MP0000920_abnormal_myelination0.77426641
136MP0005187_abnormal_penis_morphology0.77332481
137MP0002269_muscular_atrophy0.77309216
138MP0000049_abnormal_middle_ear0.76963700
139MP0000759_abnormal_skeletal_muscle0.76873957
140MP0002557_abnormal_social/conspecific_i0.73907446
141MP0001919_abnormal_reproductive_system0.73284554
142MP0000358_abnormal_cell_content/0.73028998
143MP0003938_abnormal_ear_development0.72678939
144MP0004133_heterotaxia0.69812404
145MP0005410_abnormal_fertilization0.69668615
146MP0000653_abnormal_sex_gland0.68166046
147MP0005075_abnormal_melanosome_morpholog0.66770348
148MP0002752_abnormal_somatic_nervous0.66742967

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.91192160
2Abnormal mitochondria in muscle tissue (HP:0008316)7.34247411
3Mitochondrial inheritance (HP:0001427)6.80587871
4Progressive macrocephaly (HP:0004481)6.66943351
5Acute encephalopathy (HP:0006846)6.63504712
6Increased CSF lactate (HP:0002490)5.94355832
7Hepatocellular necrosis (HP:0001404)5.77648751
8Hepatic necrosis (HP:0002605)5.31651538
9Increased hepatocellular lipid droplets (HP:0006565)5.20489252
10Cerebral edema (HP:0002181)4.96752804
11Lipid accumulation in hepatocytes (HP:0006561)4.85059590
12Abnormality of glycolysis (HP:0004366)4.48605019
13Increased serum pyruvate (HP:0003542)4.48605019
14Increased intramyocellular lipid droplets (HP:0012240)4.43656382
15Renal Fanconi syndrome (HP:0001994)4.30791519
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.28203655
17Exercise intolerance (HP:0003546)4.28028176
18Lactic acidosis (HP:0003128)4.17555062
19Respiratory failure (HP:0002878)4.13492678
20Optic disc pallor (HP:0000543)4.00586183
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.99638865
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.99638865
23Increased muscle lipid content (HP:0009058)3.95840408
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.82746154
25Leukodystrophy (HP:0002415)3.81941987
26Increased serum lactate (HP:0002151)3.71413990
273-Methylglutaconic aciduria (HP:0003535)3.57688294
28Exertional dyspnea (HP:0002875)3.26352148
29Muscle hypertrophy of the lower extremities (HP:0008968)3.08325646
30Neuroendocrine neoplasm (HP:0100634)3.03503706
31Abnormality of cells of the erythroid lineage (HP:0012130)3.03021899
32Respiratory difficulties (HP:0002880)3.01811762
33Calf muscle hypertrophy (HP:0008981)2.95479663
34Pheochromocytoma (HP:0002666)2.94711098
35Abnormality of renal resorption (HP:0011038)2.84383254
36Abnormality of urine glucose concentration (HP:0011016)2.71914129
37Glycosuria (HP:0003076)2.71914129
38Lethargy (HP:0001254)2.71760245
39CNS demyelination (HP:0007305)2.70918123
40X-linked dominant inheritance (HP:0001423)2.70017071
41Abnormal number of erythroid precursors (HP:0012131)2.69833161
42Aplastic anemia (HP:0001915)2.51804651
43Palpitations (HP:0001962)2.47673978
44Emotional lability (HP:0000712)2.47601022
45Hyperphosphaturia (HP:0003109)2.47100348
46Sudden death (HP:0001699)2.42788545
47Type I transferrin isoform profile (HP:0003642)2.42157942
48Congenital, generalized hypertrichosis (HP:0004540)2.40687556
49Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.39396865
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28756201
51Abnormality of alanine metabolism (HP:0010916)2.28756201
52Hyperalaninemia (HP:0003348)2.28756201
53Conjunctival hamartoma (HP:0100780)2.20247056
54Macrocytic anemia (HP:0001972)2.19781787
55Parakeratosis (HP:0001036)2.15768902
56Methylmalonic aciduria (HP:0012120)2.15504289
57Hyperglycinemia (HP:0002154)2.12642521
58Dicarboxylic aciduria (HP:0003215)2.12095644
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.12095644
60Ragged-red muscle fibers (HP:0003200)2.10944956
61Exercise-induced myalgia (HP:0003738)2.09242202
62Abnormality of methionine metabolism (HP:0010901)2.05583167
63Cerebral hemorrhage (HP:0001342)2.04831282
64Vomiting (HP:0002013)2.04300807
65Molar tooth sign on MRI (HP:0002419)2.04161471
66Abnormality of midbrain morphology (HP:0002418)2.04161471
67Abnormality of the anterior horn cell (HP:0006802)2.03119984
68Degeneration of anterior horn cells (HP:0002398)2.03119984
69Abnormality of serum amino acid levels (HP:0003112)2.02665993
70Abnormal urine phosphate concentration (HP:0012599)2.02593511
71Myoglobinuria (HP:0002913)1.97098794
72Abnormality of the labia minora (HP:0012880)1.93246667
73Abnormal pupillary function (HP:0007686)1.92696550
74Methylmalonic acidemia (HP:0002912)1.92099622
75Gliosis (HP:0002171)1.91047530
76Abnormality of the calf musculature (HP:0001430)1.90237091
77Microvesicular hepatic steatosis (HP:0001414)1.88927029
78Abnormality of aromatic amino acid family metabolism (HP:0004338)1.88444396
79Exercise-induced muscle cramps (HP:0003710)1.88347836
80Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88315358
81Pancreatic cysts (HP:0001737)1.87831035
82Oral leukoplakia (HP:0002745)1.86296679
83Rhabdomyolysis (HP:0003201)1.85513077
84Blindness (HP:0000618)1.84969311
85Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83735012
86Cerebral hypomyelination (HP:0006808)1.82720568
87Focal motor seizures (HP:0011153)1.82655669
88Pancreatic fibrosis (HP:0100732)1.80110815
89Amniotic constriction ring (HP:0009775)1.79348635
90Abnormality of placental membranes (HP:0011409)1.79348635
91Renal tubular dysfunction (HP:0000124)1.78800649
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76962606
93Abnormal protein N-linked glycosylation (HP:0012347)1.76962606
94Abnormal protein glycosylation (HP:0012346)1.76962606
95Abnormal glycosylation (HP:0012345)1.76962606
96Myotonia (HP:0002486)1.74917120
97Reduced antithrombin III activity (HP:0001976)1.74310206
98Progressive external ophthalmoplegia (HP:0000590)1.73964340
99Renal cortical cysts (HP:0000803)1.73276689
100Hypoglycemic coma (HP:0001325)1.69996168
101Abnormality of vitamin B metabolism (HP:0004340)1.69827798
102Rimmed vacuoles (HP:0003805)1.68894959
103Testicular atrophy (HP:0000029)1.68827363
104Megaloblastic anemia (HP:0001889)1.68547866
105Congenital ichthyosiform erythroderma (HP:0007431)1.68540500
106Nausea (HP:0002018)1.68481456
107Ventricular tachycardia (HP:0004756)1.67863246
108Esophageal neoplasm (HP:0100751)1.67131699
109Neoplasm of head and neck (HP:0012288)1.67131699
110Hypoplastic left heart (HP:0004383)1.66320682
111True hermaphroditism (HP:0010459)1.66204457
112Pancytopenia (HP:0001876)1.65613941
113Generalized aminoaciduria (HP:0002909)1.65333203
114Muscle fiber splitting (HP:0003555)1.65141324
115Colon cancer (HP:0003003)1.64791462
116Reticulocytopenia (HP:0001896)1.64774503
117Myokymia (HP:0002411)1.63596985
118Abnormality of the vitamin B12 metabolism (HP:0004341)1.63086667
119Metabolic acidosis (HP:0001942)1.60615019
120Muscle stiffness (HP:0003552)1.59060837
121Hypothermia (HP:0002045)1.58975047
122Hyperglycinuria (HP:0003108)1.58288270
123Hyperventilation (HP:0002883)1.58225665
124Syncope (HP:0001279)1.57919953
125Limb dystonia (HP:0002451)1.56446926
126Abnormality of fatty-acid metabolism (HP:0004359)1.55816805
127Poor suck (HP:0002033)1.55539922
128Pallor (HP:0000980)1.54836210
129Ketoacidosis (HP:0001993)1.54767716
130Medial flaring of the eyebrow (HP:0010747)1.54461405
131Delusions (HP:0000746)1.53075141
132Lipoatrophy (HP:0100578)1.52512226
133Respiratory insufficiency due to muscle weakness (HP:0002747)1.50789939
134Anxiety (HP:0000739)1.50262936
135Atonic seizures (HP:0010819)1.48923202

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.52926339
2NME13.69010813
3MAP3K123.30263375
4STK163.27283665
5MYLK3.01191407
6NME22.88276848
7OBSCN2.60962122
8STK392.54104605
9PNCK2.37909335
10CDC72.28474188
11ARAF2.27477916
12OXSR12.13675230
13MST42.09128359
14MUSK2.07735347
15GRK72.07124135
16WNK42.05254029
17ZAK2.02352365
18TNIK2.00621087
19BUB11.94308275
20PBK1.88963241
21BCKDK1.88863059
22CASK1.83823102
23MAP2K71.75283603
24PDK41.68552123
25PDK31.68552123
26CDK191.68529485
27NUAK11.57578328
28VRK11.54230122
29PLK41.52460739
30PLK31.45325662
31GRK51.44224646
32LIMK11.43681550
33BCR1.41565879
34MAP4K21.40678049
35EIF2AK11.38819106
36ADRBK21.33741172
37PHKG11.31532609
38PHKG21.31532609
39TRIM281.23289590
40MAP3K41.22771189
41TTK1.21277893
42GRK11.18792465
43WEE11.17635459
44CAMK2D1.16870472
45WNK31.13428350
46EIF2AK31.11338145
47EPHA41.10795135
48KDR1.08336593
49LMTK21.06456973
50CAMK2B1.03982657
51PDK21.02471502
52CAMK2A1.00964395
53PLK10.99664596
54BMPR1B0.96438935
55MAPKAPK50.94231766
56PIM20.92570124
57MARK10.91025310
58MAP2K40.91015970
59NTRK30.91011240
60CAMK2G0.89199571
61BRAF0.88213583
62PLK20.87950591
63CSNK1G10.87945461
64UHMK10.86738347
65AURKB0.85455902
66INSRR0.83544798
67TESK10.83452943
68ADRBK10.82799464
69DYRK30.80730281
70TAF10.80112539
71ABL20.80081967
72CSNK1G30.76902728
73STK240.76477725
74DYRK20.76190251
75BRSK20.76148623
76PINK10.75018485
77MKNK10.74060468
78ILK0.73153057
79MAPK130.73140309
80BMPR20.70577479
81PIK3CG0.70315622
82PIK3CA0.69569657
83SRPK10.69152754
84PRKACA0.66552852
85MINK10.66484303
86BRSK10.66286648
87PRKCE0.65539904
88ROCK20.64960788
89CSNK1A1L0.64725452
90CCNB10.64208365
91DAPK30.63803077
92DAPK10.62298980
93PAK30.61931901
94MKNK20.60945149
95CHEK20.58563876
96TESK20.56400650
97PRKCG0.56173573
98MAPK150.56171406
99PTK2B0.53491303
100RPS6KA50.52295001
101PKN10.52205118
102CSNK1E0.51772245
103ATR0.50417797
104ERBB30.49103871
105CDK140.48901977
106CDK80.48434576
107TIE10.47850438
108STK40.47519709
109LRRK20.46634498
110PASK0.45122281
111CSNK2A10.44998145
112TLK10.44329800
113MAPK120.43577323
114NEK10.43363991
115EIF2AK20.43341330
116CSNK2A20.43103796
117MAP3K110.42571696
118TSSK60.42140079
119TTN0.41440049
120CSNK1A10.39627770
121AURKA0.39614705
122ERBB40.39443679
123CSNK1G20.39034207
124RIPK40.38114212
125FGR0.38002185
126CDK180.37981782
127IRAK20.36694021
128CDK150.36325072
129GRK60.35262773
130CDK11A0.34294667
131CDK50.33637053
132PRKG10.33259491
133PRKACB0.32904548

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.58604007
2Parkinsons disease_Homo sapiens_hsa050125.66739178
3Alzheimers disease_Homo sapiens_hsa050104.26758679
4Huntingtons disease_Homo sapiens_hsa050163.96138450
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.60049144
6Ribosome_Homo sapiens_hsa030103.45744890
7Cardiac muscle contraction_Homo sapiens_hsa042603.27462287
8Proteasome_Homo sapiens_hsa030503.20463035
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.83188005
10Protein export_Homo sapiens_hsa030602.27529434
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92340246
12RNA polymerase_Homo sapiens_hsa030201.87108715
13Fatty acid elongation_Homo sapiens_hsa000621.86588217
14Collecting duct acid secretion_Homo sapiens_hsa049661.80745631
15Pyruvate metabolism_Homo sapiens_hsa006201.64033740
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61485398
17Propanoate metabolism_Homo sapiens_hsa006401.60347905
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47880740
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36140388
20Sulfur metabolism_Homo sapiens_hsa009201.35129754
21One carbon pool by folate_Homo sapiens_hsa006701.31604534
22Butanoate metabolism_Homo sapiens_hsa006501.21608068
23Carbon metabolism_Homo sapiens_hsa012001.18888851
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17314874
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17309624
26Base excision repair_Homo sapiens_hsa034101.15680505
27Nicotine addiction_Homo sapiens_hsa050331.15482083
28Vibrio cholerae infection_Homo sapiens_hsa051101.14071855
29Fanconi anemia pathway_Homo sapiens_hsa034601.02779252
30Pyrimidine metabolism_Homo sapiens_hsa002401.01282194
31RNA transport_Homo sapiens_hsa030131.00710684
32* Metabolic pathways_Homo sapiens_hsa011000.93656634
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87424038
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84367297
35Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81693801
36Phenylalanine metabolism_Homo sapiens_hsa003600.79539637
37Peroxisome_Homo sapiens_hsa041460.78753675
38Glutathione metabolism_Homo sapiens_hsa004800.76096684
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75123211
40Synaptic vesicle cycle_Homo sapiens_hsa047210.75115404
41Tyrosine metabolism_Homo sapiens_hsa003500.74059914
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73794039
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.73029061
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72322263
45Fatty acid degradation_Homo sapiens_hsa000710.71975075
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68372575
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68089025
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67523009
49Fatty acid metabolism_Homo sapiens_hsa012120.66927623
50Arginine and proline metabolism_Homo sapiens_hsa003300.65731895
51Purine metabolism_Homo sapiens_hsa002300.65568383
52Non-homologous end-joining_Homo sapiens_hsa034500.61670367
53Caffeine metabolism_Homo sapiens_hsa002320.61388960
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60467987
55Serotonergic synapse_Homo sapiens_hsa047260.60070994
56GABAergic synapse_Homo sapiens_hsa047270.59152119
57Nitrogen metabolism_Homo sapiens_hsa009100.58578711
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57987591
59Steroid biosynthesis_Homo sapiens_hsa001000.57683477
60Retinol metabolism_Homo sapiens_hsa008300.56819979
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55332774
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.53114055
63Folate biosynthesis_Homo sapiens_hsa007900.50522326
64beta-Alanine metabolism_Homo sapiens_hsa004100.50496928
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49819795
66Taste transduction_Homo sapiens_hsa047420.49370619
67Biosynthesis of amino acids_Homo sapiens_hsa012300.48523592
68Rheumatoid arthritis_Homo sapiens_hsa053230.45893282
69Histidine metabolism_Homo sapiens_hsa003400.44247989
70Spliceosome_Homo sapiens_hsa030400.42873493
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42793249
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42274069
73Nucleotide excision repair_Homo sapiens_hsa034200.39597326
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39350679
75Cell cycle_Homo sapiens_hsa041100.38944841
76Arachidonic acid metabolism_Homo sapiens_hsa005900.37819007
77Chemical carcinogenesis_Homo sapiens_hsa052040.37165788
78Linoleic acid metabolism_Homo sapiens_hsa005910.37026785
79Selenocompound metabolism_Homo sapiens_hsa004500.36752482
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36738542
81Fat digestion and absorption_Homo sapiens_hsa049750.35874786
82Calcium signaling pathway_Homo sapiens_hsa040200.35597157
83Dilated cardiomyopathy_Homo sapiens_hsa054140.35083205
84Ether lipid metabolism_Homo sapiens_hsa005650.34571721
85Morphine addiction_Homo sapiens_hsa050320.33595302
86Tryptophan metabolism_Homo sapiens_hsa003800.32480759
87Phototransduction_Homo sapiens_hsa047440.32097728
88Oocyte meiosis_Homo sapiens_hsa041140.31972631
89Vitamin digestion and absorption_Homo sapiens_hsa049770.30445473
90Regulation of autophagy_Homo sapiens_hsa041400.30284948
91Homologous recombination_Homo sapiens_hsa034400.29484443
92Mineral absorption_Homo sapiens_hsa049780.29438500
93Fructose and mannose metabolism_Homo sapiens_hsa000510.28035080
94Basal transcription factors_Homo sapiens_hsa030220.27690382
95Pentose phosphate pathway_Homo sapiens_hsa000300.27400599
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26474154
97Vitamin B6 metabolism_Homo sapiens_hsa007500.26205570
98Amphetamine addiction_Homo sapiens_hsa050310.26003438
99Sulfur relay system_Homo sapiens_hsa041220.24540829
100Circadian entrainment_Homo sapiens_hsa047130.24457625
101Glutamatergic synapse_Homo sapiens_hsa047240.24168414
102Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.23389978
103Arginine biosynthesis_Homo sapiens_hsa002200.22857819
104RNA degradation_Homo sapiens_hsa030180.21900006
105Dopaminergic synapse_Homo sapiens_hsa047280.20908615
106Mismatch repair_Homo sapiens_hsa034300.20584330
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.18585425
108Olfactory transduction_Homo sapiens_hsa047400.18333850
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.18213452
110N-Glycan biosynthesis_Homo sapiens_hsa005100.17278878
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16991575
112Phagosome_Homo sapiens_hsa041450.16935586
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.16928532
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16839460
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.16356963
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.16186270
117DNA replication_Homo sapiens_hsa030300.14846050
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.14434761
119Renin secretion_Homo sapiens_hsa049240.13312734
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12694670
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.12532805
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12171632
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11875177
124Starch and sucrose metabolism_Homo sapiens_hsa005000.10800421

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