ATP5J2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The catalytic portion of mitochondrial ATP synthase consists of five different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the f subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has multiple pseudogenes. Naturally occurring read-through transcription also exists between this gene and the downstream pentatricopeptide repeat domain 1 (PTCD1) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.90250001
2* respiratory electron transport chain (GO:0022904)9.08277033
3* electron transport chain (GO:0022900)8.84257128
4ribosomal small subunit assembly (GO:0000028)7.01838561
5maturation of SSU-rRNA (GO:0030490)6.04873631
6* ATP biosynthetic process (GO:0006754)5.80445929
7nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.69426086
8translational initiation (GO:0006413)5.47082196
9inner mitochondrial membrane organization (GO:0007007)5.46344416
10* hydrogen ion transmembrane transport (GO:1902600)5.37823570
11establishment of protein localization to mitochondrial membrane (GO:0090151)5.35172146
12oxidative phosphorylation (GO:0006119)5.33393550
13ribosomal large subunit biogenesis (GO:0042273)5.28886189
14* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.27299494
15* purine nucleoside triphosphate biosynthetic process (GO:0009145)5.17352006
16chaperone-mediated protein transport (GO:0072321)5.12489383
17protein complex disassembly (GO:0043241)4.96097375
18translation (GO:0006412)4.88998692
19proteasome assembly (GO:0043248)4.81178277
20protein complex biogenesis (GO:0070271)4.74872781
21macromolecular complex disassembly (GO:0032984)4.71591214
22* proton transport (GO:0015992)4.66709582
23* ribonucleoside triphosphate biosynthetic process (GO:0009201)4.59486222
24* hydrogen transport (GO:0006818)4.59186256
25mitochondrial respiratory chain complex I assembly (GO:0032981)4.58625513
26NADH dehydrogenase complex assembly (GO:0010257)4.58625513
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.58625513
28protein neddylation (GO:0045116)4.55688503
29protein targeting to membrane (GO:0006612)4.50045786
30mitochondrial respiratory chain complex assembly (GO:0033108)4.30502956
31ribosomal small subunit biogenesis (GO:0042274)4.30429088
32termination of RNA polymerase III transcription (GO:0006386)4.28728128
33transcription elongation from RNA polymerase III promoter (GO:0006385)4.28728128
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.21855549
35tricarboxylic acid cycle (GO:0006099)4.21853676
36nuclear-transcribed mRNA catabolic process (GO:0000956)4.11988129
37viral transcription (GO:0019083)4.01489679
38establishment of integrated proviral latency (GO:0075713)3.97392152
39cellular component biogenesis (GO:0044085)3.96641278
40ribonucleoprotein complex biogenesis (GO:0022613)3.95924084
41mRNA catabolic process (GO:0006402)3.90545783
42negative regulation of ligase activity (GO:0051352)3.89963466
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.89963466
44* nucleoside triphosphate biosynthetic process (GO:0009142)3.85369025
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.82030447
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.81127134
47translational termination (GO:0006415)3.81038170
48anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.71688278
49spliceosomal snRNP assembly (GO:0000387)3.70793686
50rRNA modification (GO:0000154)3.65956781
51cellular ketone body metabolic process (GO:0046950)3.62909206
52sarcomere organization (GO:0045214)3.61232458
53RNA catabolic process (GO:0006401)3.59578479
54regulation of oxidative phosphorylation (GO:0002082)3.59402683
55positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.53210104
56sequestering of actin monomers (GO:0042989)3.51783184
57aerobic respiration (GO:0009060)3.50971103
58regulation of cellular amino acid metabolic process (GO:0006521)3.49236212
59GTP biosynthetic process (GO:0006183)3.46601616
60rRNA processing (GO:0006364)3.45969307
61chromatin remodeling at centromere (GO:0031055)3.45816559
62CENP-A containing nucleosome assembly (GO:0034080)3.44927758
63DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.43958537
64energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.43222232
65ATP hydrolysis coupled proton transport (GO:0015991)3.43222232
66NADH metabolic process (GO:0006734)3.40386555
67* generation of precursor metabolites and energy (GO:0006091)3.38254268
68signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.38145367
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.38145367
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.38145367
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.38103388
72signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.37057425
73intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.37057425
74pseudouridine synthesis (GO:0001522)3.36939624
75* mitochondrial transport (GO:0006839)3.36545998
76cotranslational protein targeting to membrane (GO:0006613)3.34907333
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.32714648
78exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.31340479
79signal transduction involved in DNA integrity checkpoint (GO:0072401)3.30305378
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.30305378
81rRNA metabolic process (GO:0016072)3.30060378
82regulation of mitochondrial translation (GO:0070129)3.29089888
83protein targeting to ER (GO:0045047)3.29002567
84SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.25708941
85signal transduction involved in cell cycle checkpoint (GO:0072395)3.23999950
86succinate metabolic process (GO:0006105)3.23326734
87formation of translation preinitiation complex (GO:0001731)3.21445298
88establishment of protein localization to membrane (GO:0090150)3.19944597
89actin-myosin filament sliding (GO:0033275)3.18379211
90muscle filament sliding (GO:0030049)3.18379211
91establishment of protein localization to endoplasmic reticulum (GO:0072599)3.18366834
92ketone body metabolic process (GO:1902224)3.18319973
93DNA replication checkpoint (GO:0000076)3.17718969
94positive regulation of ligase activity (GO:0051351)3.17595096
95establishment of viral latency (GO:0019043)3.16983059
96* purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.16295498
97* purine nucleoside monophosphate biosynthetic process (GO:0009127)3.16295498
98protein targeting (GO:0006605)3.15956883
99spliceosomal complex assembly (GO:0000245)3.15230349
100protein localization to endoplasmic reticulum (GO:0070972)3.13992761
1017-methylguanosine mRNA capping (GO:0006370)3.07371877
102regulation of acyl-CoA biosynthetic process (GO:0050812)3.06818537
103regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.05484378
104translational elongation (GO:0006414)3.05231081
105telomere maintenance via semi-conservative replication (GO:0032201)3.05118588
106cellular protein complex disassembly (GO:0043624)3.04871284
107regulation of cell communication by electrical coupling (GO:0010649)3.01609803
108substantia nigra development (GO:0021762)3.00976501
109negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.00887728
110viral life cycle (GO:0019058)2.98865001
111regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.98387829
112regulation of cellular respiration (GO:0043457)2.96547340
113regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.94848446
114negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.93359308
115ubiquinone biosynthetic process (GO:0006744)2.92160920
116quinone biosynthetic process (GO:1901663)2.92160920
117establishment of protein localization to mitochondrion (GO:0072655)2.90789107
118calcium-mediated signaling using intracellular calcium source (GO:0035584)2.88574125
119protein targeting to mitochondrion (GO:0006626)2.87114196
120heart contraction (GO:0060047)2.85738805
121heart process (GO:0003015)2.85738805
122respiratory chain complex IV assembly (GO:0008535)2.85504412
123negative regulation of protein localization to cell surface (GO:2000009)2.84313555
124cytochrome complex assembly (GO:0017004)2.84004179
125UTP biosynthetic process (GO:0006228)2.81428789
126* purine ribonucleoside biosynthetic process (GO:0046129)2.81253880
127* purine nucleoside biosynthetic process (GO:0042451)2.81253880
128cellular respiration (GO:0045333)2.80574340
129protein localization to mitochondrion (GO:0070585)2.80448370
130dopamine transport (GO:0015872)2.80357812
131cardiac myofibril assembly (GO:0055003)2.80104891
132sarcoplasmic reticulum calcium ion transport (GO:0070296)2.77826931
133regulation of cofactor metabolic process (GO:0051193)2.76436463
134regulation of coenzyme metabolic process (GO:0051196)2.76436463
135myofibril assembly (GO:0030239)2.75281016
136ubiquinone metabolic process (GO:0006743)2.72640108
137cardiac muscle contraction (GO:0060048)2.71218044
138cardiac muscle tissue morphogenesis (GO:0055008)2.69872402
139regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.67688118
140regulation of actin filament-based movement (GO:1903115)2.67302562
141intracellular protein transmembrane import (GO:0044743)2.66855677
142fatty acid elongation (GO:0030497)2.63777193
143actin-mediated cell contraction (GO:0070252)2.62993133
144adult heart development (GO:0007512)2.60266666
145regulation of relaxation of muscle (GO:1901077)2.59180120
146ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.59150656
147regulation of protein kinase A signaling (GO:0010738)2.58881186
148UTP metabolic process (GO:0046051)2.57827768
149protein-cofactor linkage (GO:0018065)2.55097190
150negative regulation of potassium ion transmembrane transport (GO:1901380)2.53792587
151regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.52134799
152* mitochondrial ATP synthesis coupled proton transport (GO:0042776)11.1769149
153* ATP synthesis coupled proton transport (GO:0015986)10.5570955
154* energy coupled proton transport, down electrochemical gradient (GO:0015985)10.5570955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.47759133
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.45709186
3EZH2_22144423_ChIP-Seq_EOC_Human4.05424176
4E2F7_22180533_ChIP-Seq_HELA_Human3.66374079
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.36470787
6* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.34633009
7MYC_18358816_ChIP-ChIP_MESCs_Mouse3.14828046
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.09292755
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98101691
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.82325299
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80076895
12XRN2_22483619_ChIP-Seq_HELA_Human2.76193188
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.64489431
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.55051326
15* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50369669
16VDR_22108803_ChIP-Seq_LS180_Human2.47438444
17ELK1_19687146_ChIP-ChIP_HELA_Human2.46876472
18* TTF2_22483619_ChIP-Seq_HELA_Human2.42503206
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.32291092
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.29968568
21* VDR_23849224_ChIP-Seq_CD4+_Human2.29313381
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.28558515
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.28224915
24FOXP3_21729870_ChIP-Seq_TREG_Human2.27695075
25DCP1A_22483619_ChIP-Seq_HELA_Human2.27125162
26TAF15_26573619_Chip-Seq_HEK293_Human2.24957752
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14822225
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.10650682
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.07311053
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06604074
31JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05396824
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03687085
33EZH2_27304074_Chip-Seq_ESCs_Mouse2.00656380
34* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00433681
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93359189
36GBX2_23144817_ChIP-Seq_PC3_Human1.91289594
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87719470
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84583460
39GABP_19822575_ChIP-Seq_HepG2_Human1.82780338
40* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79160692
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.77202224
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.75353423
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74901308
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.70446109
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67775419
46* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66018975
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64592916
48MYC_18940864_ChIP-ChIP_HL60_Human1.64099119
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63161182
50* ETS1_20019798_ChIP-Seq_JURKAT_Human1.63139434
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63009255
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60131110
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60131110
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59925789
55* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59745699
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.59032915
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57660803
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57316069
59* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52955054
60* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49401252
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47637877
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.46722208
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46285426
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46282726
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46104745
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44984417
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41783244
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41700622
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41557936
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40505064
71FUS_26573619_Chip-Seq_HEK293_Human1.39993449
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39759888
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39066367
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38304193
75CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.37843216
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.37811395
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35389635
78SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33719490
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31919679
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27761599
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27668889
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26803832
83EP300_21415370_ChIP-Seq_HL-1_Mouse1.24962508
84* SRF_21415370_ChIP-Seq_HL-1_Mouse1.23500211
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23390427
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20956125
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20689429
88MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20379414
89KDM5A_27292631_Chip-Seq_BREAST_Human1.19705962
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19418694
91* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19327314
92* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17013854
93REST_21632747_ChIP-Seq_MESCs_Mouse1.16624709
94* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14955778
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.14849465
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14773885
97HTT_18923047_ChIP-ChIP_STHdh_Human1.14576864
98ZNF274_21170338_ChIP-Seq_K562_Hela1.14416371
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13458885
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12539763
101SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12386434
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.11644115
103ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11442829
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11378119
105FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10821850
106AR_21909140_ChIP-Seq_LNCAP_Human1.10225498
107ELK1_22589737_ChIP-Seq_MCF10A_Human1.09134614
108P300_19829295_ChIP-Seq_ESCs_Human1.09084436
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08875898
110REST_18959480_ChIP-ChIP_MESCs_Mouse1.06079297
111ZNF263_19887448_ChIP-Seq_K562_Human1.05601954
112SOX2_16153702_ChIP-ChIP_HESCs_Human1.04410652
113* ER_23166858_ChIP-Seq_MCF-7_Human1.03009875
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02087688
115SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01990519
116IRF1_19129219_ChIP-ChIP_H3396_Human1.00687155
117ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99541892
118CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97314992
119IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96914059
120NANOG_16153702_ChIP-ChIP_HESCs_Human0.96262236
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96143713
122CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95945245
123ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95614118
124THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95202163
125POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95192262
126ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94474456
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92872677
128TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92350546
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91788478
130NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91575469
131ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91031361
132POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90820288
133RNF2_27304074_Chip-Seq_ESCs_Mouse0.90713765
134SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90576415
135CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89716837
136PIAS1_25552417_ChIP-Seq_VCAP_Human0.88670032
137E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88657907
138OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88377056
139TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88095798
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87929693
141NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87670572
142SMAD3_21741376_ChIP-Seq_EPCs_Human0.87164755
143FOXP1_21924763_ChIP-Seq_HESCs_Human0.86916071
144AR_21572438_ChIP-Seq_LNCaP_Human0.85553091
145SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84215896
146SOX17_20123909_ChIP-Seq_XEN_Mouse0.82294048
147RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81417105
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81113806
149HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.80441346
150STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80218884
151RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78423042
152CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78211180
153EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.77812529
154PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77399448
155BCAT_22108803_ChIP-Seq_LS180_Human0.76069917
156FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.75849492
157POU5F1_16153702_ChIP-ChIP_HESCs_Human0.75696926
158POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.75531167
159RNF2_27304074_Chip-Seq_NSC_Mouse0.75500282
160CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74518385
161TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.74011324
162DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.73830282
163NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71244215
164TP63_19390658_ChIP-ChIP_HaCaT_Human0.69840841
165SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.65369734
166ELF5_23300383_ChIP-Seq_T47D_Human0.65003299
167ERG_20517297_ChIP-Seq_VCAP_Human0.61168862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.82933701
2MP0003880_abnormal_central_pattern3.78772447
3MP0006292_abnormal_olfactory_placode3.43455620
4MP0003646_muscle_fatigue3.42216766
5MP0000751_myopathy3.39821747
6MP0001529_abnormal_vocalization3.23655921
7MP0004957_abnormal_blastocyst_morpholog3.19593434
8MP0003693_abnormal_embryo_hatching3.02545781
9MP0004215_abnormal_myocardial_fiber3.00765107
10MP0008058_abnormal_DNA_repair2.99587002
11MP0009379_abnormal_foot_pigmentation2.89754318
12MP0004084_abnormal_cardiac_muscle2.86248841
13MP0004036_abnormal_muscle_relaxation2.72887522
14MP0010030_abnormal_orbit_morphology2.68962224
15MP0006036_abnormal_mitochondrial_physio2.53350062
16MP0000749_muscle_degeneration2.46906738
17MP0002938_white_spotting2.46017838
18MP0010094_abnormal_chromosome_stability2.45584001
19MP0005330_cardiomyopathy2.38593639
20MP0003111_abnormal_nucleus_morphology2.35607166
21MP0006276_abnormal_autonomic_nervous2.35313337
22MP0003137_abnormal_impulse_conducting2.21756662
23MP0003077_abnormal_cell_cycle2.19367949
24MP0006035_abnormal_mitochondrial_morpho2.16931472
25MP0008932_abnormal_embryonic_tissue2.14362066
26MP0003718_maternal_effect2.03598720
27MP0001905_abnormal_dopamine_level2.01486093
28MP0000372_irregular_coat_pigmentation2.01182090
29MP0001440_abnormal_grooming_behavior1.99615771
30MP0002972_abnormal_cardiac_muscle1.91458998
31MP0004484_altered_response_of1.86093830
32MP0003786_premature_aging1.82147457
33MP0002736_abnormal_nociception_after1.81955843
34MP0004145_abnormal_muscle_electrophysio1.78190723
35MP0001968_abnormal_touch/_nociception1.72984600
36MP0000566_synostosis1.71031680
37MP0005620_abnormal_muscle_contractility1.70910173
38MP0003941_abnormal_skin_development1.68243597
39MP0008007_abnormal_cellular_replicative1.68241475
40MP0004142_abnormal_muscle_tone1.66095567
41MP0009697_abnormal_copulation1.65783122
42MP0009745_abnormal_behavioral_response1.65511604
43MP0001293_anophthalmia1.65227753
44MP0005408_hypopigmentation1.62988068
45MP0002332_abnormal_exercise_endurance1.61666142
46MP0002277_abnormal_respiratory_mucosa1.60249963
47MP0004085_abnormal_heartbeat1.58437235
48MP0009046_muscle_twitch1.58161908
49MP0002822_catalepsy1.58102926
50MP0002064_seizures1.57677916
51MP0000750_abnormal_muscle_regeneration1.56555264
52MP0002272_abnormal_nervous_system1.56222350
53MP0002106_abnormal_muscle_physiology1.54671616
54MP0008995_early_reproductive_senescence1.51313095
55MP0008789_abnormal_olfactory_epithelium1.48278660
56MP0003123_paternal_imprinting1.45962194
57MP0003315_abnormal_perineum_morphology1.45003443
58MP0008775_abnormal_heart_ventricle1.43552733
59MP0003136_yellow_coat_color1.42620682
60MP0001544_abnormal_cardiovascular_syste1.41806477
61MP0005385_cardiovascular_system_phenoty1.41806477
62MP0004924_abnormal_behavior1.40315934
63MP0005386_behavior/neurological_phenoty1.40315934
64MP0004087_abnormal_muscle_fiber1.40269058
65MP0003635_abnormal_synaptic_transmissio1.40200165
66MP0005084_abnormal_gallbladder_morpholo1.35512218
67MP0002572_abnormal_emotion/affect_behav1.35150708
68MP0006138_congestive_heart_failure1.34685269
69MP0000747_muscle_weakness1.30290067
70MP0005369_muscle_phenotype1.30060901
71MP0003938_abnormal_ear_development1.28941038
72MP0004043_abnormal_pH_regulation1.27837397
73MP0001727_abnormal_embryo_implantation1.27422577
74MP0002735_abnormal_chemical_nociception1.25307895
75MP0001501_abnormal_sleep_pattern1.24803172
76MP0004147_increased_porphyrin_level1.22263708
77MP0003806_abnormal_nucleotide_metabolis1.22180572
78MP0001486_abnormal_startle_reflex1.17082360
79MP0002734_abnormal_mechanical_nocicepti1.16498892
80MP0002638_abnormal_pupillary_reflex1.15517615
81MP0002067_abnormal_sensory_capabilities1.14233382
82MP0001970_abnormal_pain_threshold1.13762447
83MP0004270_analgesia1.12568239
84MP0001346_abnormal_lacrimal_gland1.12066179
85MP0005451_abnormal_body_composition1.10846553
86MP0002697_abnormal_eye_size1.09768736
87MP0000759_abnormal_skeletal_muscle1.09208162
88MP0005423_abnormal_somatic_nervous1.08906976
89MP0001764_abnormal_homeostasis1.08705886
90MP0002210_abnormal_sex_determination1.08236929
91MP0002063_abnormal_learning/memory/cond1.07963703
92MP0004130_abnormal_muscle_cell1.07106293
93MP0000049_abnormal_middle_ear1.06135866
94MP0003950_abnormal_plasma_membrane1.05228707
95MP0000631_abnormal_neuroendocrine_gland1.04707864
96MP0002733_abnormal_thermal_nociception1.04280854
97MP0002127_abnormal_cardiovascular_syste1.03719051
98MP0005535_abnormal_body_temperature1.03457360
99MP0002234_abnormal_pharynx_morphology1.03214092
100MP0001984_abnormal_olfaction1.03107609
101MP0005266_abnormal_metabolism1.00354360
102MP0002160_abnormal_reproductive_system0.99408436
103MP0003329_amyloid_beta_deposits0.99318035
104MP0002269_muscular_atrophy0.96969084
105MP0002095_abnormal_skin_pigmentation0.95154788
106MP0008875_abnormal_xenobiotic_pharmacok0.94210608
107MP0001286_abnormal_eye_development0.92886546
108MP0005394_taste/olfaction_phenotype0.91710541
109MP0005499_abnormal_olfactory_system0.91710541
110MP0003567_abnormal_fetal_cardiomyocyte0.91186305
111MP0006072_abnormal_retinal_apoptosis0.91177625
112MP0000358_abnormal_cell_content/0.91003035
113MP0001485_abnormal_pinna_reflex0.90056889
114MP0005165_increased_susceptibility_to0.89710965
115MP0000350_abnormal_cell_proliferation0.89629164
116MP0000778_abnormal_nervous_system0.89617615
117MP0005332_abnormal_amino_acid0.89252204
118MP0003195_calcinosis0.87778274
119MP0002163_abnormal_gland_morphology0.87348983
120MP0003122_maternal_imprinting0.87311034
121MP0000230_abnormal_systemic_arterial0.86960437
122MP0005083_abnormal_biliary_tract0.86840649
123MP0001188_hyperpigmentation0.86427906
124MP0003221_abnormal_cardiomyocyte_apopto0.85911597
125MP0002653_abnormal_ependyma_morphology0.85568241
126MP0004859_abnormal_synaptic_plasticity0.84786037
127MP0005551_abnormal_eye_electrophysiolog0.83133556
128MP0004742_abnormal_vestibular_system0.82970553
129MP0005646_abnormal_pituitary_gland0.81545601
130MP0001919_abnormal_reproductive_system0.81338825
131MP0005409_darkened_coat_color0.80782739
132MP0005360_urolithiasis0.80596478
133MP0002184_abnormal_innervation0.80565471
134MP0003937_abnormal_limbs/digits/tail_de0.80281648
135MP0010630_abnormal_cardiac_muscle0.79082221
136MP0000313_abnormal_cell_death0.78213223
137MP0002132_abnormal_respiratory_system0.77931332
138MP0005389_reproductive_system_phenotype0.77188655
139MP0001929_abnormal_gametogenesis0.77085868
140MP0001145_abnormal_male_reproductive0.76931659
141MP0000920_abnormal_myelination0.76582436
142MP0002066_abnormal_motor_capabilities/c0.76260029
143MP0004019_abnormal_vitamin_homeostasis0.75937387
144MP0005085_abnormal_gallbladder_physiolo0.74650801
145MP0001697_abnormal_embryo_size0.73543282
146MP0002876_abnormal_thyroid_physiology0.73525109
147MP0000653_abnormal_sex_gland0.73070384
148MP0005379_endocrine/exocrine_gland_phen0.72800761
149MP0002282_abnormal_trachea_morphology0.72597759
150MP0003011_delayed_dark_adaptation0.72490598
151MP0001881_abnormal_mammary_gland0.71912579
152MP0003186_abnormal_redox_activity0.71495190
153MP0002557_abnormal_social/conspecific_i0.71103777
154MP0002233_abnormal_nose_morphology0.69999388
155MP0008872_abnormal_physiological_respon0.69323893
156MP0002090_abnormal_vision0.68855440
157MP0005636_abnormal_mineral_homeostasis0.68445482
158MP0000579_abnormal_nail_morphology0.68406722
159MP0005410_abnormal_fertilization0.67946556
160MP0003828_pulmonary_edema0.67027005
161MP0005253_abnormal_eye_physiology0.66846962
162MP0000026_abnormal_inner_ear0.66785389
163MP0002229_neurodegeneration0.66714315
164MP0004133_heterotaxia0.65026408
165MP0002085_abnormal_embryonic_tissue0.64815423
166MP0002111_abnormal_tail_morphology0.63174628
167MP0005075_abnormal_melanosome_morpholog0.62109851
168MP0005391_vision/eye_phenotype0.61821642
169MP0009250_abnormal_appendicular_skeleto0.60992974
170MP0001853_heart_inflammation0.59608238

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)8.04250359
2Abnormal mitochondria in muscle tissue (HP:0008316)7.34749753
3Progressive macrocephaly (HP:0004481)6.84006771
4Acute encephalopathy (HP:0006846)6.80942008
5Mitochondrial inheritance (HP:0001427)6.64013448
6Increased CSF lactate (HP:0002490)5.65230226
7Hepatocellular necrosis (HP:0001404)5.44027977
8Cerebral edema (HP:0002181)5.21320968
9Hepatic necrosis (HP:0002605)5.06656949
10Increased hepatocellular lipid droplets (HP:0006565)5.00619775
11Lipid accumulation in hepatocytes (HP:0006561)4.75985376
12Increased intramyocellular lipid droplets (HP:0012240)4.31462471
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.24351952
14Renal Fanconi syndrome (HP:0001994)4.19908458
15Exercise intolerance (HP:0003546)4.16495579
16Optic disc pallor (HP:0000543)4.10919888
17Respiratory failure (HP:0002878)4.09884945
18Sudden death (HP:0001699)4.08820293
19Increased muscle lipid content (HP:0009058)3.98666306
20Lactic acidosis (HP:0003128)3.91608775
21Leukodystrophy (HP:0002415)3.84297628
22Muscle hypertrophy of the lower extremities (HP:0008968)3.79572785
23Calf muscle hypertrophy (HP:0008981)3.76657032
24Increased serum pyruvate (HP:0003542)3.72904316
25Abnormality of glycolysis (HP:0004366)3.72904316
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.63713927
27Pallor (HP:0000980)3.56413116
28Decreased activity of mitochondrial respiratory chain (HP:0008972)3.39811819
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.39811819
30Aplasia/Hypoplasia of the sacrum (HP:0008517)3.26451948
31Increased serum lactate (HP:0002151)3.18962016
323-Methylglutaconic aciduria (HP:0003535)3.17586016
33Aplastic anemia (HP:0001915)3.14405164
34Congenital, generalized hypertrichosis (HP:0004540)3.13324896
35Exertional dyspnea (HP:0002875)3.03160567
36Ventricular tachycardia (HP:0004756)2.91150684
37Exercise-induced myalgia (HP:0003738)2.86180492
38Pheochromocytoma (HP:0002666)2.85382572
39Palpitations (HP:0001962)2.84952521
40Respiratory difficulties (HP:0002880)2.80651030
41Neuroendocrine neoplasm (HP:0100634)2.78398886
42X-linked dominant inheritance (HP:0001423)2.77319847
43Lethargy (HP:0001254)2.72803596
44Oral leukoplakia (HP:0002745)2.71264327
45Abnormality of renal resorption (HP:0011038)2.71012509
46Abnormality of cells of the erythroid lineage (HP:0012130)2.69356488
47Abnormality of the calf musculature (HP:0001430)2.65287179
48Abnormality of urine glucose concentration (HP:0011016)2.54771304
49Glycosuria (HP:0003076)2.54771304
50Generalized aminoaciduria (HP:0002909)2.54363489
51Type I transferrin isoform profile (HP:0003642)2.51162074
52Conjunctival hamartoma (HP:0100780)2.50027286
53Exercise-induced muscle cramps (HP:0003710)2.48883157
54Myoglobinuria (HP:0002913)2.46898830
55Myotonia (HP:0002486)2.46166270
56Syncope (HP:0001279)2.44083437
57Myokymia (HP:0002411)2.43825855
58Microvesicular hepatic steatosis (HP:0001414)2.43385161
59Muscle fiber splitting (HP:0003555)2.41285983
60CNS demyelination (HP:0007305)2.40268806
61Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.39295953
62Hyperphosphaturia (HP:0003109)2.38057726
63Atrial fibrillation (HP:0005110)2.35932358
64Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27828437
65Dicarboxylic aciduria (HP:0003215)2.27828437
66Primary atrial arrhythmia (HP:0001692)2.26250943
67Parakeratosis (HP:0001036)2.26178433
68Supraventricular tachycardia (HP:0004755)2.26012069
69Emotional lability (HP:0000712)2.25175842
70Colon cancer (HP:0003003)2.24339723
71Muscle stiffness (HP:0003552)2.23140155
72Lipoatrophy (HP:0100578)2.21807713
73Prolonged QT interval (HP:0001657)2.19207323
74Abnormal number of erythroid precursors (HP:0012131)2.19068079
75Supraventricular arrhythmia (HP:0005115)2.18110358
76Testicular atrophy (HP:0000029)2.16206795
77Cerebral hemorrhage (HP:0001342)2.16087366
78Septo-optic dysplasia (HP:0100842)2.13924437
79Sensory axonal neuropathy (HP:0003390)2.12363526
80Vomiting (HP:0002013)2.12243025
81Pancytopenia (HP:0001876)2.10356698
82Absent thumb (HP:0009777)2.08439497
83Abnormal urine phosphate concentration (HP:0012599)2.07579418
84Abnormality of the anterior horn cell (HP:0006802)2.06955871
85Degeneration of anterior horn cells (HP:0002398)2.06955871
86Rhabdomyolysis (HP:0003201)2.04392922
87Macrocytic anemia (HP:0001972)2.02772626
88Sparse eyelashes (HP:0000653)2.00868379
89EMG: myopathic abnormalities (HP:0003458)1.97669144
90Abnormality of methionine metabolism (HP:0010901)1.97559700
91Focal motor seizures (HP:0011153)1.97353880
92Methylmalonic aciduria (HP:0012120)1.97330702
93Hypoplastic left heart (HP:0004383)1.93684656
94Hyporeflexia of lower limbs (HP:0002600)1.92093820
95Partial duplication of thumb phalanx (HP:0009944)1.91876870
96Dilated cardiomyopathy (HP:0001644)1.90924317
97Birth length less than 3rd percentile (HP:0003561)1.86956457
98Progressive external ophthalmoplegia (HP:0000590)1.85402647
99Ketoacidosis (HP:0001993)1.85399799
100Abnormality of reticulocytes (HP:0004312)1.83979600
101Methylmalonic acidemia (HP:0002912)1.83914432
102Ragged-red muscle fibers (HP:0003200)1.83130996
103Cleft eyelid (HP:0000625)1.81937934
104Multiple enchondromatosis (HP:0005701)1.81181100
105Partial duplication of the phalanx of hand (HP:0009999)1.80107003
106Blindness (HP:0000618)1.78521721
107Abnormality of placental membranes (HP:0011409)1.78173406
108Amniotic constriction ring (HP:0009775)1.78173406
109Absent septum pellucidum (HP:0001331)1.77788974
110Hyperglycinemia (HP:0002154)1.77628937
111Megaloblastic anemia (HP:0001889)1.77584720
112Reduced antithrombin III activity (HP:0001976)1.77429320
113Right ventricular cardiomyopathy (HP:0011663)1.76230772
114Congenital ichthyosiform erythroderma (HP:0007431)1.76023700
115Triphalangeal thumb (HP:0001199)1.75756706
116Meckel diverticulum (HP:0002245)1.71232177
117Abnormality of serum amino acid levels (HP:0003112)1.70887972
118Double outlet right ventricle (HP:0001719)1.70788188
119Congenital malformation of the right heart (HP:0011723)1.70788188
120Renal tubular dysfunction (HP:0000124)1.70362832
121Abnormality of fatty-acid metabolism (HP:0004359)1.70107097
122Left ventricular hypertrophy (HP:0001712)1.69073837
123Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.68390660
124Abnormal protein N-linked glycosylation (HP:0012347)1.68390660
125Abnormal protein glycosylation (HP:0012346)1.68390660
126Abnormal glycosylation (HP:0012345)1.68390660
127Gliosis (HP:0002171)1.68383854
128Rough bone trabeculation (HP:0100670)1.67831392
129Nasolacrimal duct obstruction (HP:0000579)1.67399940
130Abnormality of aromatic amino acid family metabolism (HP:0004338)1.67057803
131Esophageal neoplasm (HP:0100751)1.66922003
132Neoplasm of head and neck (HP:0012288)1.66922003
133Sclerocornea (HP:0000647)1.66163547
134Ventricular arrhythmia (HP:0004308)1.65641883
135Abnormality of aspartate family amino acid metabolism (HP:0010899)1.65452210
136Abnormality of the labia minora (HP:0012880)1.65059287
137Depressed nasal ridge (HP:0000457)1.64630008
138Reticulocytopenia (HP:0001896)1.62733948
139Rimmed vacuoles (HP:0003805)1.62733715
140Abnormal number of incisors (HP:0011064)1.60997251
141Abnormal pupillary function (HP:0007686)1.60723554
142Hyperventilation (HP:0002883)1.60453567
143Abnormality of the ileum (HP:0001549)1.59088432
144Nausea (HP:0002018)1.57862958
145Rib fusion (HP:0000902)1.54135616
146Maternal diabetes (HP:0009800)1.53979736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.61006302
2MYLK3.77276116
3NME13.59900671
4CDC73.31771196
5MAP3K123.09513107
6OBSCN2.91378862
7NME22.81708816
8STK392.79771731
9GRK72.72103935
10PNCK2.60141780
11ZAK2.51103614
12SRPK12.39947284
13MUSK2.38280053
14BCKDK2.28702134
15WNK42.20893624
16PHKG22.12504779
17PHKG12.12504779
18NEK12.04412953
19TAF12.02469337
20OXSR11.97683725
21ARAF1.85533750
22EIF2AK11.84739760
23PIK3CA1.83989652
24GRK51.82225955
25TTK1.79702299
26MST41.78224914
27CASK1.75105910
28TTN1.72022549
29MAP2K71.65525878
30MAP3K41.64731932
31PDK31.64029235
32PDK41.64029235
33STK161.62364019
34LMTK21.57666905
35EPHA41.57135269
36TESK21.56645954
37CAMK2D1.55505684
38PLK31.55299246
39PBK1.52992542
40PLK41.49320576
41WEE11.43247435
42PKN11.33456987
43NUAK11.33430993
44CDK81.31906521
45CAMK2A1.31758926
46RIPK41.22148532
47MAP2K41.21383370
48LIMK11.20999824
49BCR1.19539799
50AURKB1.18665836
51FGR1.18186881
52MARK11.16707767
53CHEK21.16135947
54DAPK31.15487082
55CAMK2B1.12964850
56PLK11.12444822
57TNIK1.10842803
58TESK11.10673271
59BRSK11.10291230
60TLK11.08747952
61ROCK21.06614020
62PAK31.05863176
63AURKA1.04117809
64ADRBK21.03719801
65DYRK31.01718997
66NTRK31.01607247
67BRSK21.01224826
68ILK0.97929063
69PDK20.97787942
70PASK0.97189609
71ADRBK10.97169343
72CAMK2G0.96603773
73CDK190.96388438
74UHMK10.95076735
75ABL20.93392440
76LRRK20.92022895
77BMPR20.92021177
78PTK2B0.91297884
79CCNB10.86339683
80PINK10.85708667
81ATR0.82733913
82PRKCE0.82704013
83WNK30.80002734
84PRKACA0.79967872
85PIM20.78994433
86TSSK60.77607759
87CSNK2A10.76549096
88MAPK130.76261740
89NEK20.75699230
90STK240.75604911
91STK40.74918811
92MAPK120.74873247
93PLK20.74344413
94MST1R0.74190135
95PAK40.74084772
96RPS6KB20.73981577
97MKNK10.72517204
98MAPKAPK50.71387927
99MINK10.70488262
100GRK60.69729421
101VRK10.69140463
102BMPR1B0.68382961
103RPS6KA50.66713058
104ROCK10.65629772
105INSRR0.62538713
106DAPK10.62269739
107CDK70.61924151
108DYRK20.60920650
109EPHB20.57471791
110TIE10.56541808
111BRAF0.53379869
112PIK3CG0.52686688
113NTRK10.50083040
114PRKCG0.50076588
115PAK10.48402436
116NTRK20.47537343
117MAP3K110.47057098
118CSNK1E0.46644890
119GRK10.46500334
120EIF2AK30.45343201
121PRKD10.45003766
122EIF2AK20.44838256
123CDK50.42841041
124PRKG10.41388300
125CSNK1G30.41224134
126CHEK10.40465757
127IRAK20.40127892
128CDK140.39808435
129PRKACB0.39613560
130PRKCQ0.39326476
131CSNK1G10.38359698
132CAMK10.37983983
133CDC42BPA0.37975390
134MAP4K20.37880712
135PRKCA0.37491438
136CSNK1G20.36790205
137PRKCI0.35217541
138MAPK40.34812475
139MAP2K10.33674536
140CLK10.33567574
141WNK10.33425970
142MAPK150.33098881
143CSNK2A20.32243914
144PRKACG0.32035778
145FES0.31723499
146KDR0.31637533
147CDK150.31322784
148CDK180.29955826
149BUB10.29885963
150CDK10.29840419
151MAPKAPK30.29413652
152CDK11A0.29343797
153ATM0.27958478
154MKNK20.27216432
155CSNK1A10.26687415
156CDK30.26345580
157CDK20.25719077
158ALK0.23415988
159RPS6KA40.23344153

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.68757748
2Parkinsons disease_Homo sapiens_hsa050125.79329318
3Alzheimers disease_Homo sapiens_hsa050104.55159018
4Huntingtons disease_Homo sapiens_hsa050164.00508567
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.81532964
6Cardiac muscle contraction_Homo sapiens_hsa042603.78292087
7Ribosome_Homo sapiens_hsa030103.04427341
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.83456901
9DNA replication_Homo sapiens_hsa030302.75327611
10Mismatch repair_Homo sapiens_hsa034302.63059420
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.58831155
12Homologous recombination_Homo sapiens_hsa034402.26095557
13Spliceosome_Homo sapiens_hsa030402.03231677
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96233910
15Proteasome_Homo sapiens_hsa030501.95730062
16Propanoate metabolism_Homo sapiens_hsa006401.88500794
17Fatty acid elongation_Homo sapiens_hsa000621.85048630
18Nucleotide excision repair_Homo sapiens_hsa034201.76982559
19Sulfur metabolism_Homo sapiens_hsa009201.71827944
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70123316
21Butanoate metabolism_Homo sapiens_hsa006501.63759268
22Collecting duct acid secretion_Homo sapiens_hsa049661.57707204
23Pyruvate metabolism_Homo sapiens_hsa006201.56785177
24Base excision repair_Homo sapiens_hsa034101.56469671
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54692964
26One carbon pool by folate_Homo sapiens_hsa006701.43654926
27Folate biosynthesis_Homo sapiens_hsa007901.36967771
28RNA transport_Homo sapiens_hsa030131.28048984
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27551688
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26513404
31Carbon metabolism_Homo sapiens_hsa012001.23035654
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.19214425
33Fanconi anemia pathway_Homo sapiens_hsa034601.19009190
34RNA degradation_Homo sapiens_hsa030181.18972446
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18035313
36Protein export_Homo sapiens_hsa030601.15412288
37Nicotine addiction_Homo sapiens_hsa050331.13323854
38Basal transcription factors_Homo sapiens_hsa030221.11926214
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10121029
40Fatty acid degradation_Homo sapiens_hsa000711.09892774
41Phenylalanine metabolism_Homo sapiens_hsa003600.97757550
42RNA polymerase_Homo sapiens_hsa030200.96597755
43Fatty acid metabolism_Homo sapiens_hsa012120.96162340
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92877023
45Dilated cardiomyopathy_Homo sapiens_hsa054140.88968185
46Tyrosine metabolism_Homo sapiens_hsa003500.88792792
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88593210
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84480724
49* Metabolic pathways_Homo sapiens_hsa011000.82178002
50Vibrio cholerae infection_Homo sapiens_hsa051100.81633989
51Cell cycle_Homo sapiens_hsa041100.81534943
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76502140
53Non-homologous end-joining_Homo sapiens_hsa034500.76118944
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75804229
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75029820
56Peroxisome_Homo sapiens_hsa041460.70054571
57Serotonergic synapse_Homo sapiens_hsa047260.65229285
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63536289
59Taste transduction_Homo sapiens_hsa047420.62685205
60GABAergic synapse_Homo sapiens_hsa047270.61945878
61Glutathione metabolism_Homo sapiens_hsa004800.61334428
62beta-Alanine metabolism_Homo sapiens_hsa004100.59632812
63Arginine and proline metabolism_Homo sapiens_hsa003300.59002922
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58854268
65Synaptic vesicle cycle_Homo sapiens_hsa047210.53280890
66Chemical carcinogenesis_Homo sapiens_hsa052040.53116484
67Linoleic acid metabolism_Homo sapiens_hsa005910.52967533
68Systemic lupus erythematosus_Homo sapiens_hsa053220.50524351
69Histidine metabolism_Homo sapiens_hsa003400.50354180
70PPAR signaling pathway_Homo sapiens_hsa033200.50143927
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49563209
72Tryptophan metabolism_Homo sapiens_hsa003800.47467462
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47451407
74Ether lipid metabolism_Homo sapiens_hsa005650.46250604
75Calcium signaling pathway_Homo sapiens_hsa040200.44185240
76Steroid biosynthesis_Homo sapiens_hsa001000.43965674
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.43295451
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.42824782
79Renin secretion_Homo sapiens_hsa049240.42426936
80Vitamin digestion and absorption_Homo sapiens_hsa049770.41653950
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41327331
82Arachidonic acid metabolism_Homo sapiens_hsa005900.41168523
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40554480
84Selenocompound metabolism_Homo sapiens_hsa004500.39776354
85Morphine addiction_Homo sapiens_hsa050320.38010386
86Glutamatergic synapse_Homo sapiens_hsa047240.37720178
87Rheumatoid arthritis_Homo sapiens_hsa053230.37255188
88Nitrogen metabolism_Homo sapiens_hsa009100.37052693
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36636716
90Phototransduction_Homo sapiens_hsa047440.36573813
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35484397
92Salivary secretion_Homo sapiens_hsa049700.34048553
93Biosynthesis of amino acids_Homo sapiens_hsa012300.34038982
94Sulfur relay system_Homo sapiens_hsa041220.33809404
95Vitamin B6 metabolism_Homo sapiens_hsa007500.33774664
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33530335
97mRNA surveillance pathway_Homo sapiens_hsa030150.32992679
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.32634173
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32600559
100Pentose phosphate pathway_Homo sapiens_hsa000300.32343358
101Gastric acid secretion_Homo sapiens_hsa049710.31394493
102Circadian entrainment_Homo sapiens_hsa047130.31290152
103Fat digestion and absorption_Homo sapiens_hsa049750.30911824
104Epstein-Barr virus infection_Homo sapiens_hsa051690.30410687
105Pyrimidine metabolism_Homo sapiens_hsa002400.29869765
106N-Glycan biosynthesis_Homo sapiens_hsa005100.29704739
107Amphetamine addiction_Homo sapiens_hsa050310.28323714
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27370035
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26321584
110Oocyte meiosis_Homo sapiens_hsa041140.25214739
111Basal cell carcinoma_Homo sapiens_hsa052170.25208231
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25161935
113Dopaminergic synapse_Homo sapiens_hsa047280.23811968
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.23249294
115Fructose and mannose metabolism_Homo sapiens_hsa000510.23218030
116Long-term potentiation_Homo sapiens_hsa047200.22554679
117Starch and sucrose metabolism_Homo sapiens_hsa005000.22044790
118Long-term depression_Homo sapiens_hsa047300.21845062
119Oxytocin signaling pathway_Homo sapiens_hsa049210.21314038
120Galactose metabolism_Homo sapiens_hsa000520.18743014
121Alcoholism_Homo sapiens_hsa050340.17697171
122Purine metabolism_Homo sapiens_hsa002300.17576345
123Cholinergic synapse_Homo sapiens_hsa047250.16216111
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15564800
125Pancreatic secretion_Homo sapiens_hsa049720.15190345
126Mineral absorption_Homo sapiens_hsa049780.14929832
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.14401359
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.13754383
129Arginine biosynthesis_Homo sapiens_hsa002200.13427711
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.13035141
131Retinol metabolism_Homo sapiens_hsa008300.12846281
132p53 signaling pathway_Homo sapiens_hsa041150.12833117
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12667111
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11338140
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.11172200
136Asthma_Homo sapiens_hsa053100.10343561
137Gap junction_Homo sapiens_hsa045400.09951027
138Insulin secretion_Homo sapiens_hsa049110.09220203
139Phagosome_Homo sapiens_hsa041450.08843247
140Caffeine metabolism_Homo sapiens_hsa002320.07709434

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