ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	galactose catabolic process (GO:0019388)	4.98491659
2	positive regulation of male gonad development (GO:2000020)	4.83419551
3	signal peptide processing (GO:0006465)	4.29946779
4	negative chemotaxis (GO:0050919)	4.25704621
5	regulation of relaxation of muscle (GO:1901077)	4.22941722
6	neurotransmitter uptake (GO:0001504)	4.19549402
7	interferon-gamma production (GO:0032609)	4.11782739
8	negative regulation of execution phase of apoptosis (GO:1900118)	4.05774115
9	negative regulation of axon extension involved in axon guidance (GO:0048843)	4.05265438
10	neuromuscular process controlling posture (GO:0050884)	4.04414627
11	glucosamine-containing compound catabolic process (GO:1901072)	4.04387698
12	protein K6-linked ubiquitination (GO:0085020)	3.95575507
13	regulation of male gonad development (GO:2000018)	3.87679178
14	olfactory bulb development (GO:0021772)	3.86354598
15	alkaloid metabolic process (GO:0009820)	3.61928735
16	proteasome assembly (GO:0043248)	3.56297710
17	negative regulation of axon guidance (GO:1902668)	3.42435539
18	platelet dense granule organization (GO:0060155)	3.42319764
19	positive regulation of vesicle fusion (GO:0031340)	3.40121346
20	sterol biosynthetic process (GO:0016126)	3.39644977
21	positive regulation of mast cell activation (GO:0033005)	3.39250393
22	positive regulation of histone H3-K4 methylation (GO:0051571)	3.37842563
23	DNA demethylation (GO:0080111)	3.35088627
24	glycosphingolipid biosynthetic process (GO:0006688)	3.32819290
25	negative regulation of macroautophagy (GO:0016242)	3.29362342
26	oxidative demethylation (GO:0070989)	3.29128259
27	cholesterol biosynthetic process (GO:0006695)	3.27559007
28	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	3.27216194
29	fatty acid elongation (GO:0030497)	3.27129196
30	mannosylation (GO:0097502)	3.17367816
31	regulation of extracellular matrix disassembly (GO:0010715)	3.13206862
32	chaperone-mediated protein transport (GO:0072321)	3.09099491
33	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.07081093
34	termination of RNA polymerase III transcription (GO:0006386)	3.07081093
35	DNA replication initiation (GO:0006270)	3.05630321
36	intracellular pH reduction (GO:0051452)	3.02582205
37	regulation of corticosteroid hormone secretion (GO:2000846)	2.99630169
38	positive regulation of developmental pigmentation (GO:0048087)	2.99225554
39	DNA double-strand break processing (GO:0000729)	2.99105234
40	angiogenesis involved in wound healing (GO:0060055)	2.96135601
41	protein heterotetramerization (GO:0051290)	2.92776030
42	regulation of telomerase activity (GO:0051972)	2.91248989
43	blood coagulation, intrinsic pathway (GO:0007597)	2.91061627
44	photoreceptor cell maintenance (GO:0045494)	2.91053612
45	regulation of transmission of nerve impulse (GO:0051969)	2.90999457
46	protein K11-linked deubiquitination (GO:0035871)	2.87341793
47	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.86651496
48	thrombin receptor signaling pathway (GO:0070493)	2.85330674
49	single strand break repair (GO:0000012)	2.82418067
50	cullin deneddylation (GO:0010388)	2.79945458
51	protein localization to Golgi apparatus (GO:0034067)	2.79341659
52	insulin secretion (GO:0030073)	2.78608693
53	regulation of glucocorticoid secretion (GO:2000849)	2.77014283
54	ganglion development (GO:0061548)	2.76784364
55	regulation of receptor biosynthetic process (GO:0010869)	2.76101925
56	transcription from RNA polymerase III promoter (GO:0006383)	2.74982902
57	heparin metabolic process (GO:0030202)	2.74960864
58	heparin biosynthetic process (GO:0030210)	2.74960864
59	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.69799688
60	histone H4 deacetylation (GO:0070933)	2.67618512
61	sialylation (GO:0097503)	2.65465469
62	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.65238410
63	negative regulation of T-helper cell differentiation (GO:0045623)	2.64451395
64	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.64451395
65	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.63795219
66	S-adenosylmethionine metabolic process (GO:0046500)	2.63587416
67	adaptation of signaling pathway (GO:0023058)	2.62625830
68	purine nucleobase biosynthetic process (GO:0009113)	2.61589216
69	endosome to pigment granule transport (GO:0043485)	2.60322444
70	endosome to melanosome transport (GO:0035646)	2.60322444
71	purine-containing compound salvage (GO:0043101)	2.59839406
72	peptidyl-histidine modification (GO:0018202)	2.59351421
73	terpenoid biosynthetic process (GO:0016114)	2.58925676
74	intestinal cholesterol absorption (GO:0030299)	2.57070621
75	ubiquinone metabolic process (GO:0006743)	2.56960789
76	peroxisome fission (GO:0016559)	2.56783340
77	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.56639730
78	DNA dealkylation (GO:0035510)	2.56165600
79	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.55624844
80	ganglioside metabolic process (GO:0001573)	2.55461137
81	dopamine transport (GO:0015872)	2.55088441
82	intra-Golgi vesicle-mediated transport (GO:0006891)	2.54248387
83	DNA unwinding involved in DNA replication (GO:0006268)	2.53250130
84	galactose metabolic process (GO:0006012)	2.51618674
85	regulation of telomere maintenance via telomerase (GO:0032210)	2.49989956
86	negative regulation of telomere maintenance (GO:0032205)	2.49860926
87	histone mRNA metabolic process (GO:0008334)	2.48620292
88	neurofilament cytoskeleton organization (GO:0060052)	2.47471968
89	regulation of intracellular pH (GO:0051453)	2.47140796
90	regulation of cilium movement (GO:0003352)	2.47125104
91	ncRNA 3-end processing (GO:0043628)	2.47083769
92	inner mitochondrial membrane organization (GO:0007007)	2.46207466
93	regulation of steroid hormone secretion (GO:2000831)	2.43409846
94	regulation of homotypic cell-cell adhesion (GO:0034110)	2.42922703
95	purine nucleotide salvage (GO:0032261)	2.40893251
96	regulation of phospholipase A2 activity (GO:0032429)	2.40633752
97	response to X-ray (GO:0010165)	2.40178534
98	protein complex biogenesis (GO:0070271)	2.38823211
99	C-terminal protein amino acid modification (GO:0018410)	2.35778404
100	mitochondrial respiratory chain complex assembly (GO:0033108)	2.34917581

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.71477444
2	E2F7_22180533_ChIP-Seq_HELA_Human	4.62847270
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.45092710
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.34312943
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.71538529
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.71311765
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.67201700
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.63362555
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.41249350
10	IRF1_19129219_ChIP-ChIP_H3396_Human	2.34669795
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.32000238
12	FUS_26573619_Chip-Seq_HEK293_Human	2.19206823
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.18896280
14	EWS_26573619_Chip-Seq_HEK293_Human	2.17386992
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.07172738
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.03019775
17	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.00433027
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.97970670
19	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.95499206
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.91881179
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.89943936
22	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.85978076
23	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.85872862
24	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.83754086
25	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.74867310
26	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.74459505
27	P300_19829295_ChIP-Seq_ESCs_Human	1.73802772
28	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.68423231
29	GBX2_23144817_ChIP-Seq_PC3_Human	1.66558061
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.64196514
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.64196514
32	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.60631873
33	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.58290861
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.46911885
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.44219599
36	SCL_19346495_ChIP-Seq_HPC-7_Human	1.42141235
37	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.41921252
38	ZNF274_21170338_ChIP-Seq_K562_Hela	1.41479948
39	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.38474760
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.38412476
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.37055098
42	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.36998466
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.36754942
44	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.35664841
45	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.33862439
46	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.28954147
47	RNF2_27304074_Chip-Seq_NSC_Mouse	1.27641102
48	VDR_23849224_ChIP-Seq_CD4+_Human	1.27396279
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.27181650
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23245818
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23245818
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23051790
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23051790
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22889264
55	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.22852181
56	AR_20517297_ChIP-Seq_VCAP_Human	1.22502775
57	ER_23166858_ChIP-Seq_MCF-7_Human	1.22304591
58	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20991521
59	MYC_18940864_ChIP-ChIP_HL60_Human	1.20216315
60	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.19279988
61	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.17967615
62	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14754476
63	AR_25329375_ChIP-Seq_VCAP_Human	1.14684808
64	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.14590877
65	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14311384
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14011633
67	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.13202442
68	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.12149837
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10365681
70	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.09778266
71	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.09712040
72	HTT_18923047_ChIP-ChIP_STHdh_Human	1.09205406
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.08448214
74	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.07478554
75	STAT3_23295773_ChIP-Seq_U87_Human	1.05674170
76	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.04896959
77	FOXP3_21729870_ChIP-Seq_TREG_Human	1.03858988
78	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.03612797
79	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.02999077
80	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02999077
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01967745
82	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.01658764
83	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.01538613
84	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.00185497
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.99174983
86	GATA3_26560356_Chip-Seq_TH2_Human	0.99015345
87	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.98476590
88	AR_21572438_ChIP-Seq_LNCaP_Human	0.96291748
89	BCAT_22108803_ChIP-Seq_LS180_Human	0.93668193
90	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.92937522
91	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.92465427
92	TP53_16413492_ChIP-PET_HCT116_Human	0.92446324
93	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.92055296
94	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.91499826
95	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.91258208
96	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.91209233
97	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.90356336
98	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.90081828
99	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.89424711
100	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.88560424

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005084_abnormal_gallbladder_morpholo	3.93291707
2	MP0000015_abnormal_ear_pigmentation	3.67999130
3	MP0006276_abnormal_autonomic_nervous	3.66742074
4	MP0008004_abnormal_stomach_pH	3.53133691
5	MP0003195_calcinosis	3.26407609
6	MP0005464_abnormal_platelet_physiology	2.99144124
7	MP0010386_abnormal_urinary_bladder	2.66338824
8	MP0002396_abnormal_hematopoietic_system	2.61891909
9	MP0001529_abnormal_vocalization	2.40472284
10	MP0003880_abnormal_central_pattern	2.37609097
11	MP0000538_abnormal_urinary_bladder	2.29134924
12	MP0008007_abnormal_cellular_replicative	2.25660884
13	MP0006072_abnormal_retinal_apoptosis	2.09009041
14	MP0002638_abnormal_pupillary_reflex	1.89690261
15	MP0001727_abnormal_embryo_implantation	1.86035883
16	MP0003890_abnormal_embryonic-extraembry	1.83202322
17	MP0000569_abnormal_digit_pigmentation	1.76890718
18	MP0002095_abnormal_skin_pigmentation	1.72274671
19	MP0003656_abnormal_erythrocyte_physiolo	1.71668157
20	MP0004142_abnormal_muscle_tone	1.67538647
21	MP0008057_abnormal_DNA_replication	1.65661985
22	MP0010094_abnormal_chromosome_stability	1.63068458
23	MP0005253_abnormal_eye_physiology	1.57181860
24	MP0003122_maternal_imprinting	1.55436416
25	MP0008875_abnormal_xenobiotic_pharmacok	1.54470361
26	MP0003724_increased_susceptibility_to	1.52845696
27	MP0004510_myositis	1.48996634
28	MP0001986_abnormal_taste_sensitivity	1.47780122
29	MP0008995_early_reproductive_senescence	1.46106704
30	MP0003806_abnormal_nucleotide_metabolis	1.38904254
31	MP0003252_abnormal_bile_duct	1.37402899
32	MP0008058_abnormal_DNA_repair	1.36699756
33	MP0010329_abnormal_lipoprotein_level	1.36300997
34	MP0004084_abnormal_cardiac_muscle	1.30023688
35	MP0008877_abnormal_DNA_methylation	1.29505379
36	MP0003786_premature_aging	1.28811268
37	MP0008872_abnormal_physiological_respon	1.27716893
38	MP0004085_abnormal_heartbeat	1.18163748
39	MP0001835_abnormal_antigen_presentation	1.17986815
40	MP0001666_abnormal_nutrient_absorption	1.15746301
41	MP0005645_abnormal_hypothalamus_physiol	1.15009647
42	MP0003172_abnormal_lysosome_physiology	1.13008883
43	MP0005083_abnormal_biliary_tract	1.12330820
44	MP0005448_abnormal_energy_balance	1.09858885
45	MP0003943_abnormal_hepatobiliary_system	1.09300600
46	MP0005165_increased_susceptibility_to	1.07723328
47	MP0000465_gastrointestinal_hemorrhage	1.07216892
48	MP0004484_altered_response_of	1.06371684
49	MP0003075_altered_response_to	1.06363459
50	MP0003718_maternal_effect	1.01525374
51	MP0005646_abnormal_pituitary_gland	0.99217908
52	MP0005075_abnormal_melanosome_morpholog	0.96573886
53	MP0001502_abnormal_circadian_rhythm	0.95202327
54	MP0003121_genomic_imprinting	0.95030467
55	MP0002876_abnormal_thyroid_physiology	0.93497756
56	MP0001853_heart_inflammation	0.93460289
57	MP0003077_abnormal_cell_cycle	0.93274542
58	MP0002736_abnormal_nociception_after	0.92307405
59	MP0000778_abnormal_nervous_system	0.90188813
60	MP0002971_abnormal_brown_adipose	0.88434241
61	MP0002069_abnormal_eating/drinking_beha	0.86413741
62	MP0003787_abnormal_imprinting	0.85743449
63	MP0003111_abnormal_nucleus_morphology	0.84080171
64	MP0002653_abnormal_ependyma_morphology	0.82920593
65	MP0002909_abnormal_adrenal_gland	0.80726508
66	MP0001905_abnormal_dopamine_level	0.80340096
67	MP0005166_decreased_susceptibility_to	0.77816011
68	MP0009764_decreased_sensitivity_to	0.76534124
69	MP0009765_abnormal_xenobiotic_induced	0.76509495
70	MP0000372_irregular_coat_pigmentation	0.74814924
71	MP0005452_abnormal_adipose_tissue	0.74633866
72	MP0008932_abnormal_embryonic_tissue	0.73734499
73	MP0004808_abnormal_hematopoietic_stem	0.72981921
74	MP0002078_abnormal_glucose_homeostasis	0.72741934
75	MP0005174_abnormal_tail_pigmentation	0.72058351
76	MP0002751_abnormal_autonomic_nervous	0.71802989
77	MP0001324_abnormal_eye_pigmentation	0.71215832
78	MP0000689_abnormal_spleen_morphology	0.70850468
79	MP0005332_abnormal_amino_acid	0.69627928
80	MP0000358_abnormal_cell_content/	0.69041116
81	MP0002019_abnormal_tumor_incidence	0.68740824
82	MP0003953_abnormal_hormone_level	0.68687021
83	MP0001756_abnormal_urination	0.68568505
84	MP0005551_abnormal_eye_electrophysiolog	0.67770845
85	MP0009697_abnormal_copulation	0.67391726
86	MP0000230_abnormal_systemic_arterial	0.67160154
87	MP0000858_altered_metastatic_potential	0.66432471
88	MP0001764_abnormal_homeostasis	0.64316890
89	MP0009046_muscle_twitch	0.64025503
90	MP0002067_abnormal_sensory_capabilities	0.63984213
91	MP0002557_abnormal_social/conspecific_i	0.63760983
92	MP0009763_increased_sensitivity_to	0.63750824
93	MP0001984_abnormal_olfaction	0.62626349
94	MP0002398_abnormal_bone_marrow	0.62405004
95	MP0003868_abnormal_feces_composition	0.62145601
96	MP0002572_abnormal_emotion/affect_behav	0.62004277
97	MP0004957_abnormal_blastocyst_morpholog	0.61826530
98	MP0000516_abnormal_urinary_system	0.61154625
99	MP0005367_renal/urinary_system_phenotyp	0.61154625
100	MP0003221_abnormal_cardiomyocyte_apopto	0.60700510

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Petechiae (HP:0000967)	4.69333305
2	Pancreatic islet-cell hyperplasia (HP:0004510)	4.20140654
3	Large for gestational age (HP:0001520)	3.98105224
4	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.94763836
5	Gingival bleeding (HP:0000225)	3.79123964
6	Menorrhagia (HP:0000132)	3.69323713
7	Increased neuronal autofluorescent lipopigment (HP:0002074)	3.69159862
8	Prolonged bleeding time (HP:0003010)	3.56586773
9	Increased mean platelet volume (HP:0011877)	3.46159023
10	Abnormality of the ileum (HP:0001549)	3.45666212
11	Abnormality of the preputium (HP:0100587)	3.41053386
12	Albinism (HP:0001022)	3.37974564
13	Meckel diverticulum (HP:0002245)	3.27372595
14	Abnormal platelet volume (HP:0011876)	3.26722127
15	Pancreatic cysts (HP:0001737)	3.08810716
16	Oligodactyly (hands) (HP:0001180)	3.06171748
17	Agitation (HP:0000713)	3.01922198
18	Vacuolated lymphocytes (HP:0001922)	3.00295915
19	Hypothermia (HP:0002045)	2.89658067
20	Abnormality of chromosome stability (HP:0003220)	2.88052101
21	Increased cerebral lipofuscin (HP:0011813)	2.85642719
22	Abolished electroretinogram (ERG) (HP:0000550)	2.79103112
23	Septate vagina (HP:0001153)	2.78891776
24	Abnormal hair whorl (HP:0010721)	2.74625130
25	Hypoplastic pelvis (HP:0008839)	2.74566387
26	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.73433512
27	Intestinal atresia (HP:0011100)	2.67345041
28	Abnormality of the pancreatic islet cells (HP:0006476)	2.65372420
29	Abnormality of endocrine pancreas physiology (HP:0012093)	2.65372420
30	Purpura (HP:0000979)	2.61173271
31	True hermaphroditism (HP:0010459)	2.54363892
32	Papillary thyroid carcinoma (HP:0002895)	2.53200506
33	Abnormal platelet function (HP:0011869)	2.38523578
34	Impaired platelet aggregation (HP:0003540)	2.38523578
35	Epistaxis (HP:0000421)	2.36377832
36	Abnormality of the renal medulla (HP:0100957)	2.35517419
37	Clubbing of toes (HP:0100760)	2.32804887
38	Tubulointerstitial nephritis (HP:0001970)	2.31702198
39	Myelodysplasia (HP:0002863)	2.18132708
40	Postural tremor (HP:0002174)	2.16775618
41	Fatigue (HP:0012378)	2.16663096
42	Pancreatic fibrosis (HP:0100732)	2.16542116
43	Medial flaring of the eyebrow (HP:0010747)	2.16307180
44	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.15623819
45	Bone marrow hypocellularity (HP:0005528)	2.15017197
46	Abnormality of the renal cortex (HP:0011035)	2.13850033
47	Neoplasm of the adrenal cortex (HP:0100641)	2.13514594
48	Lissencephaly (HP:0001339)	2.13115699
49	Prominent metopic ridge (HP:0005487)	2.12986575
50	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.12690879
51	Hypoplastic female external genitalia (HP:0012815)	2.11543284
52	Retinal dysplasia (HP:0007973)	2.09685847
53	Small intestinal stenosis (HP:0012848)	2.07942107
54	Duodenal stenosis (HP:0100867)	2.07942107
55	Type II lissencephaly (HP:0007260)	2.02932275
56	Abnormality of the carotid arteries (HP:0005344)	2.02513629
57	Nephronophthisis (HP:0000090)	1.99773626
58	Tubulointerstitial abnormality (HP:0001969)	1.99153687
59	Thyroid carcinoma (HP:0002890)	1.98582285
60	Molar tooth sign on MRI (HP:0002419)	1.97418309
61	Abnormality of midbrain morphology (HP:0002418)	1.97418309
62	Labial hypoplasia (HP:0000066)	1.97258362
63	Prostate neoplasm (HP:0100787)	1.95052803
64	Abnormality of the duodenum (HP:0002246)	1.93263101
65	Ketoacidosis (HP:0001993)	1.92956783
66	Abnormal protein glycosylation (HP:0012346)	1.92231232
67	Abnormal glycosylation (HP:0012345)	1.92231232
68	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.92231232
69	Abnormal protein N-linked glycosylation (HP:0012347)	1.92231232
70	Cerebellar dysplasia (HP:0007033)	1.91272426
71	Volvulus (HP:0002580)	1.90063348
72	Epidermoid cyst (HP:0200040)	1.87687621
73	Spinal muscular atrophy (HP:0007269)	1.86282789
74	Occipital encephalocele (HP:0002085)	1.84715768
75	Absent speech (HP:0001344)	1.83721585
76	Oligodactyly (HP:0012165)	1.80546923
77	Abnormality of the metopic suture (HP:0005556)	1.80466565
78	Poor suck (HP:0002033)	1.77059470
79	Hepatocellular necrosis (HP:0001404)	1.76806040
80	Insulin-resistant diabetes mellitus (HP:0000831)	1.76774229
81	Congenital primary aphakia (HP:0007707)	1.76360416
82	Postnatal microcephaly (HP:0005484)	1.76011789
83	Generalized hypopigmentation (HP:0007513)	1.75805792
84	Acute myeloid leukemia (HP:0004808)	1.74421951
85	Congenital hepatic fibrosis (HP:0002612)	1.74311123
86	Inability to walk (HP:0002540)	1.71507451
87	Limb hypertonia (HP:0002509)	1.68513423
88	Fair hair (HP:0002286)	1.67214673
89	Pulmonary fibrosis (HP:0002206)	1.66974064
90	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.66139830
91	Gait imbalance (HP:0002141)	1.65795591
92	Choroideremia (HP:0001139)	1.64879111
93	Abnormality of male internal genitalia (HP:0000022)	1.63647641
94	Type I transferrin isoform profile (HP:0003642)	1.63079283
95	Febrile seizures (HP:0002373)	1.61443883
96	Anencephaly (HP:0002323)	1.60193030
97	Curly hair (HP:0002212)	1.60183784
98	Hemiparesis (HP:0001269)	1.59850042
99	Double outlet right ventricle (HP:0001719)	1.58188079
100	Congenital malformation of the right heart (HP:0011723)	1.58188079

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	5.37762603
2	GRK7	3.12297469
3	MST1R	2.89232736
4	NUAK1	2.84432956
5	WNK3	2.84377286
6	STK38L	2.60566392
7	BCKDK	2.54096370
8	SIK3	2.34903798
9	STK38	2.31883614
10	TRIM28	2.31211322
11	MAP3K4	2.14466925
12	BMPR1B	2.06147117
13	STK16	1.89291441
14	ERBB3	1.85033606
15	FLT3	1.83614911
16	MAPK13	1.82602542
17	PKN1	1.77045499
18	BRSK2	1.67397688
19	ADRBK2	1.63807269
20	EIF2AK3	1.63459918
21	FRK	1.61493057
22	VRK2	1.58469822
23	DAPK2	1.38870462
24	STK10	1.35729483
25	MET	1.29118491
26	IRAK2	1.29094579
27	GRK1	1.23000617
28	MAP4K2	1.17659905
29	BMX	1.17654502
30	IRAK1	1.15671175
31	CSF1R	1.15631821
32	AKT3	1.15273122
33	TAOK3	1.13616972
34	CDC7	1.12620705
35	EPHA3	1.06110125
36	SRPK1	1.05053846
37	GRK5	1.04775700
38	NEK1	1.04157543
39	ADRBK1	1.02447416
40	MAP2K7	1.01994694
41	TAF1	1.01582920
42	CAMK1	1.01266433
43	BCR	1.00560928
44	TRPM7	0.99887306
45	TEC	0.96453462
46	EIF2AK1	0.96194865
47	TNK2	0.90242513
48	PBK	0.87363561
49	OXSR1	0.86720088
50	MKNK2	0.86034214
51	CDK8	0.82996642
52	PIK3CG	0.82679997
53	CSNK1G3	0.82591705
54	DYRK2	0.81550419
55	LMTK2	0.80791505
56	KDR	0.80760997
57	EIF2AK2	0.77843868
58	TGFBR2	0.76897807
59	CSNK1A1L	0.75385616
60	MOS	0.74360379
61	VRK1	0.70974444
62	DAPK1	0.65884448
63	IKBKB	0.65777358
64	CSNK1G2	0.65146967
65	SYK	0.65110263
66	PAK3	0.63508438
67	ACVR1B	0.63116359
68	PLK2	0.62515168
69	PTK2B	0.61067349
70	CSNK1G1	0.58883620
71	STK4	0.55327242
72	PLK3	0.54591797
73	PRKAA2	0.54395521
74	IGF1R	0.52485399
75	STK3	0.48492431
76	ATR	0.47223251
77	BRAF	0.45669835
78	CHEK2	0.45104705
79	PLK1	0.44419182
80	MINK1	0.42876493
81	PLK4	0.42534676
82	TESK2	0.40507676
83	PRKD2	0.39364936
84	MKNK1	0.37993840
85	RET	0.37513096
86	CLK1	0.36838019
87	PDK1	0.35696549
88	MAP3K12	0.32960171
89	ATM	0.31480721
90	PRKCE	0.31150599
91	PIM2	0.30425718
92	KSR1	0.29737086
93	CAMK1G	0.29531585
94	SGK2	0.29343415
95	TIE1	0.29264172
96	TXK	0.28499025
97	INSRR	0.26308931
98	MAP3K7	0.26226219
99	PRKACG	0.25455568
100	TESK1	0.25180366

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Steroid biosynthesis_Homo sapiens_hsa00100	3.78206505
2	DNA replication_Homo sapiens_hsa03030	3.43776150
3	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.16472690
4	Fanconi anemia pathway_Homo sapiens_hsa03460	3.04897715
5	Homologous recombination_Homo sapiens_hsa03440	2.97348229
6	Mismatch repair_Homo sapiens_hsa03430	2.95152828
7	Proteasome_Homo sapiens_hsa03050	2.73476568
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.67076273
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.36317813
10	Protein export_Homo sapiens_hsa03060	2.36154145
11	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.31243921
12	Sulfur metabolism_Homo sapiens_hsa00920	2.18150120
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.92090798
14	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.88523299
15	Folate biosynthesis_Homo sapiens_hsa00790	1.85985907
16	Oxidative phosphorylation_Homo sapiens_hsa00190	1.81153285
17	Circadian rhythm_Homo sapiens_hsa04710	1.77468942
18	Asthma_Homo sapiens_hsa05310	1.73385241
19	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.72446909
20	Fat digestion and absorption_Homo sapiens_hsa04975	1.64413339
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.58916763
22	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.57181515
23	Non-homologous end-joining_Homo sapiens_hsa03450	1.54863562
24	Pancreatic secretion_Homo sapiens_hsa04972	1.43889820
25	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.39469109
26	Parkinsons disease_Homo sapiens_hsa05012	1.39203385
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.37990604
28	Base excision repair_Homo sapiens_hsa03410	1.31713304
29	Olfactory transduction_Homo sapiens_hsa04740	1.31320021
30	Fatty acid elongation_Homo sapiens_hsa00062	1.31045594
31	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.29453126
32	One carbon pool by folate_Homo sapiens_hsa00670	1.21085364
33	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.08430077
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.06421074
35	Butanoate metabolism_Homo sapiens_hsa00650	1.04272741
36	Glycerolipid metabolism_Homo sapiens_hsa00561	1.02817181
37	Collecting duct acid secretion_Homo sapiens_hsa04966	0.98633002
38	Rheumatoid arthritis_Homo sapiens_hsa05323	0.96932994
39	Type I diabetes mellitus_Homo sapiens_hsa04940	0.94278355
40	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.92507155
41	Ether lipid metabolism_Homo sapiens_hsa00565	0.91510691
42	Peroxisome_Homo sapiens_hsa04146	0.90807524
43	Huntingtons disease_Homo sapiens_hsa05016	0.90040858
44	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.87393422
45	Nucleotide excision repair_Homo sapiens_hsa03420	0.85263797
46	Linoleic acid metabolism_Homo sapiens_hsa00591	0.84884844
47	Platelet activation_Homo sapiens_hsa04611	0.83920636
48	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.83095175
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.81593823
50	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.80243107
51	Nitrogen metabolism_Homo sapiens_hsa00910	0.79868358
52	Alzheimers disease_Homo sapiens_hsa05010	0.78380546
53	Phototransduction_Homo sapiens_hsa04744	0.77519474
54	Spliceosome_Homo sapiens_hsa03040	0.70725263
55	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.69055336
56	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.69002990
57	Glutathione metabolism_Homo sapiens_hsa00480	0.68461404
58	Purine metabolism_Homo sapiens_hsa00230	0.68031126
59	Sphingolipid metabolism_Homo sapiens_hsa00600	0.67944621
60	Legionellosis_Homo sapiens_hsa05134	0.66702594
61	Cell cycle_Homo sapiens_hsa04110	0.66352658
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.66283478
63	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.64668207
64	Fatty acid metabolism_Homo sapiens_hsa01212	0.64025177
65	Viral myocarditis_Homo sapiens_hsa05416	0.62550605
66	Allograft rejection_Homo sapiens_hsa05330	0.62083971
67	Tuberculosis_Homo sapiens_hsa05152	0.60450686
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.59351136
69	Mineral absorption_Homo sapiens_hsa04978	0.57380035
70	RNA degradation_Homo sapiens_hsa03018	0.56703711
71	Metabolic pathways_Homo sapiens_hsa01100	0.55419599
72	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.52890991
73	Insulin secretion_Homo sapiens_hsa04911	0.52788282
74	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.51789465
75	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.50640465
76	Cardiac muscle contraction_Homo sapiens_hsa04260	0.49119110
77	RNA transport_Homo sapiens_hsa03013	0.47377658
78	RNA polymerase_Homo sapiens_hsa03020	0.45300299
79	Melanoma_Homo sapiens_hsa05218	0.45270087
80	Basal transcription factors_Homo sapiens_hsa03022	0.44770015
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.44750477
82	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.44390098
83	Graft-versus-host disease_Homo sapiens_hsa05332	0.41759300
84	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.41307497
85	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.41114422
86	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.39910290
87	Serotonergic synapse_Homo sapiens_hsa04726	0.39907463
88	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37918229
89	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.37277232
90	Pyrimidine metabolism_Homo sapiens_hsa00240	0.35117419
91	Salivary secretion_Homo sapiens_hsa04970	0.34503745
92	Galactose metabolism_Homo sapiens_hsa00052	0.33409688
93	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.31924672
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.30968310
95	Phagosome_Homo sapiens_hsa04145	0.30663201
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.30466897
97	beta-Alanine metabolism_Homo sapiens_hsa00410	0.29106733
98	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.29024844
99	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.26785832
100	Propanoate metabolism_Homo sapiens_hsa00640	0.26762004

ATP5J2P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »