ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	6.60600441
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.35753062
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.08524418
4	ATP synthesis coupled proton transport (GO:0015986)	6.08524418
5	pyrimidine nucleotide catabolic process (GO:0006244)	5.85866765
6	ribosomal small subunit biogenesis (GO:0042274)	5.62258272
7	viral transcription (GO:0019083)	5.37709074
8	protein neddylation (GO:0045116)	5.11709904
9	translational termination (GO:0006415)	5.08762127
10	respiratory electron transport chain (GO:0022904)	4.66823479
11	electron transport chain (GO:0022900)	4.55447673
12	cotranslational protein targeting to membrane (GO:0006613)	4.48112057
13	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	4.46511755
14	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.46330151
15	proteasome assembly (GO:0043248)	4.41567077
16	protein targeting to ER (GO:0045047)	4.39015240
17	translational elongation (GO:0006414)	4.34116290
18	ribosomal small subunit assembly (GO:0000028)	4.29499497
19	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.20355413
20	positive regulation of cAMP-mediated signaling (GO:0043950)	4.18942008
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.07747618
22	protein localization to endoplasmic reticulum (GO:0070972)	4.05466402
23	deoxyribonucleotide catabolic process (GO:0009264)	4.03865984
24	behavioral response to nicotine (GO:0035095)	3.83880531
25	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.78328320
26	response to redox state (GO:0051775)	3.76229183
27	ribosomal large subunit biogenesis (GO:0042273)	3.73682635
28	DNA methylation involved in gamete generation (GO:0043046)	3.72843268
29	cellular protein complex disassembly (GO:0043624)	3.72358894
30	hydrogen ion transmembrane transport (GO:1902600)	3.68212839
31	protein complex biogenesis (GO:0070271)	3.66973641
32	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.63924994
33	opioid receptor signaling pathway (GO:0038003)	3.62063846
34	piRNA metabolic process (GO:0034587)	3.61712997
35	GTP biosynthetic process (GO:0006183)	3.61460253
36	deoxyribose phosphate catabolic process (GO:0046386)	3.61122247
37	chaperone-mediated protein transport (GO:0072321)	3.60557584
38	viral life cycle (GO:0019058)	3.60452726
39	folic acid-containing compound biosynthetic process (GO:0009396)	3.59047777
40	spinal cord association neuron differentiation (GO:0021527)	3.58175854
41	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.55553022
42	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.55553022
43	NADH dehydrogenase complex assembly (GO:0010257)	3.55553022
44	DNA deamination (GO:0045006)	3.54956801
45	base-excision repair, AP site formation (GO:0006285)	3.51869635
46	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.46637172
47	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.41809863
48	synapsis (GO:0007129)	3.34244631
49	mitochondrial respiratory chain complex assembly (GO:0033108)	3.33845148
50	maturation of SSU-rRNA (GO:0030490)	3.33111198
51	proton transport (GO:0015992)	3.31873985
52	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.30936129
53	glomerulus development (GO:0032835)	3.30412356
54	translational initiation (GO:0006413)	3.29219596
55	myoblast migration (GO:0051451)	3.27159976
56	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.27005895
57	hydrogen transport (GO:0006818)	3.23466058
58	ATP biosynthetic process (GO:0006754)	3.21296932
59	ncRNA 3-end processing (GO:0043628)	3.19312566
60	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.18132577
61	arginine catabolic process (GO:0006527)	3.12251464
62	positive regulation of defense response to virus by host (GO:0002230)	3.09970534
63	forebrain neuron differentiation (GO:0021879)	3.07724811
64	cell proliferation in forebrain (GO:0021846)	3.07230096
65	negative regulation of nitric oxide biosynthetic process (GO:0045019)	3.00086451
66	behavioral response to ethanol (GO:0048149)	2.98698687
67	DNA demethylation (GO:0080111)	2.98024020
68	peptidyl-histidine modification (GO:0018202)	2.95465175
69	startle response (GO:0001964)	2.95370368
70	translation (GO:0006412)	2.95181541
71	protein complex disassembly (GO:0043241)	2.94635113
72	regulation of synapse structural plasticity (GO:0051823)	2.93280819
73	macromolecular complex disassembly (GO:0032984)	2.92835034
74	protein targeting to membrane (GO:0006612)	2.87674019
75	UTP biosynthetic process (GO:0006228)	2.85672113
76	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.84935247
77	genetic imprinting (GO:0071514)	2.83441012
78	negative regulation of systemic arterial blood pressure (GO:0003085)	2.83197073
79	negative regulation of cAMP-mediated signaling (GO:0043951)	2.78654871
80	neurofilament cytoskeleton organization (GO:0060052)	2.76455170
81	pyrimidine-containing compound catabolic process (GO:0072529)	2.75934613
82	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.71286623
83	somite development (GO:0061053)	2.71267251
84	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.70840485
85	ribonucleoprotein complex disassembly (GO:0032988)	2.69254008
86	pyrimidine nucleoside catabolic process (GO:0046135)	2.68008035
87	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.67463998
88	protein peptidyl-prolyl isomerization (GO:0000413)	2.65169327
89	regulation of glycogen (starch) synthase activity (GO:2000465)	2.63872464
90	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.63276650
91	cellular component biogenesis (GO:0044085)	2.62075067
92	cytidine metabolic process (GO:0046087)	2.61069515
93	cytidine catabolic process (GO:0006216)	2.61069515
94	cytidine deamination (GO:0009972)	2.61069515
95	negative regulation of glucose import (GO:0046325)	2.59672315
96	sequestering of actin monomers (GO:0042989)	2.58787879
97	negative regulation of mast cell activation (GO:0033004)	2.58606641
98	cardiac left ventricle morphogenesis (GO:0003214)	2.58197531
99	oxidative demethylation (GO:0070989)	2.57492822
100	ribonucleoprotein complex biogenesis (GO:0022613)	2.56878743

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.30874094
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.15441265
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.99146856
4	VDR_22108803_ChIP-Seq_LS180_Human	3.43995779
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.16244997
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.74553277
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.59619240
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.57325764
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.50706347
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.47726818
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.43421311
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.23535904
13	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.21645559
14	IRF1_19129219_ChIP-ChIP_H3396_Human	2.19488810
15	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.14188565
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.13616370
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.13369327
18	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.98168717
19	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.94249428
20	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.84592473
21	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.77473599
22	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.70644330
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.69220666
24	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.68375187
25	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.57995654
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.57835444
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55603558
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.54310808
29	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.54282228
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.51674500
31	VDR_23849224_ChIP-Seq_CD4+_Human	1.46482842
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.44610833
33	GBX2_23144817_ChIP-Seq_PC3_Human	1.43476547
34	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.43021299
35	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.41596657
36	REST_21632747_ChIP-Seq_MESCs_Mouse	1.40301628
37	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.38146685
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.37006126
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.36620637
40	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.35298519
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.34002541
42	EWS_26573619_Chip-Seq_HEK293_Human	1.33166796
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30650446
44	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.29472248
45	HTT_18923047_ChIP-ChIP_STHdh_Human	1.29129829
46	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.26519488
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26492300
48	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.22479332
49	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.20803397
50	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.19211110
51	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18825610
52	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.18802036
53	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.18095743
54	FUS_26573619_Chip-Seq_HEK293_Human	1.17766272
55	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16645370
56	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.16388213
57	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.16388213
58	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13979372
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.12538251
60	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.12047793
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11858965
62	NCOR_22424771_ChIP-Seq_293T_Human	1.10832124
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10682777
64	ER_23166858_ChIP-Seq_MCF-7_Human	1.10209415
65	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09714231
66	ELK1_19687146_ChIP-ChIP_HELA_Human	1.09683308
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.08340840
68	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.05963642
69	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.05897484
70	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.05506572
71	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.05480215
72	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.04886525
73	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.04546315
74	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.04438501
75	CBP_20019798_ChIP-Seq_JUKART_Human	1.04438501
76	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.04102645
77	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.03841017
78	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.03570775
79	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03425401
80	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.03157379
81	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.01227336
82	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.01109948
83	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.00372696
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.99627297
85	MYC_19829295_ChIP-Seq_ESCs_Human	0.97047485
86	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.96718222
87	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.94155342
88	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.94155342
89	P300_19829295_ChIP-Seq_ESCs_Human	0.93848002
90	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.92988478
91	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.92842292
92	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.91031675
93	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.90165789
94	NANOG_20526341_ChIP-Seq_ESCs_Human	0.89100931
95	STAT1_20625510_ChIP-Seq_HELA_Human	0.87699680
96	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.86631380
97	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.86601442
98	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.85733962
99	FOXP3_21729870_ChIP-Seq_TREG_Human	0.85407607
100	ERG_20517297_ChIP-Seq_VCAP_Human	0.85177041

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003122_maternal_imprinting	3.51454250
2	MP0009379_abnormal_foot_pigmentation	3.39394905
3	MP0003787_abnormal_imprinting	3.36971086
4	MP0004145_abnormal_muscle_electrophysio	3.35629326
5	MP0001968_abnormal_touch/_nociception	3.35160075
6	MP0002102_abnormal_ear_morphology	3.34583080
7	MP0005645_abnormal_hypothalamus_physiol	3.31054608
8	MP0001348_abnormal_lacrimal_gland	3.19517587
9	MP0001984_abnormal_olfaction	2.70866039
10	MP0004742_abnormal_vestibular_system	2.55520443
11	MP0002733_abnormal_thermal_nociception	2.40794541
12	MP0001188_hyperpigmentation	2.26787614
13	MP0003121_genomic_imprinting	2.26735334
14	MP0002138_abnormal_hepatobiliary_system	2.23092770
15	MP0001970_abnormal_pain_threshold	2.17794027
16	MP0008877_abnormal_DNA_methylation	2.15554275
17	MP0008872_abnormal_physiological_respon	2.12314881
18	MP0008875_abnormal_xenobiotic_pharmacok	2.10044533
19	MP0005423_abnormal_somatic_nervous	2.09655572
20	MP0002736_abnormal_nociception_after	2.06210800
21	MP0003646_muscle_fatigue	1.93890265
22	MP0006292_abnormal_olfactory_placode	1.88748980
23	MP0009745_abnormal_behavioral_response	1.81371134
24	MP0002163_abnormal_gland_morphology	1.68781491
25	MP0001905_abnormal_dopamine_level	1.64662044
26	MP0003011_delayed_dark_adaptation	1.58112642
27	MP0001986_abnormal_taste_sensitivity	1.48201334
28	MP0006276_abnormal_autonomic_nervous	1.47267310
29	MP0002063_abnormal_learning/memory/cond	1.45801307
30	MP0003880_abnormal_central_pattern	1.44952061
31	MP0004142_abnormal_muscle_tone	1.40588197
32	MP0002734_abnormal_mechanical_nocicepti	1.40211152
33	MP0001440_abnormal_grooming_behavior	1.38968355
34	MP0004885_abnormal_endolymph	1.37530377
35	MP0002272_abnormal_nervous_system	1.35762101
36	MP0002572_abnormal_emotion/affect_behav	1.35113658
37	MP0002184_abnormal_innervation	1.33742194
38	MP0003635_abnormal_synaptic_transmissio	1.33374130
39	MP0001486_abnormal_startle_reflex	1.33130606
40	MP0002557_abnormal_social/conspecific_i	1.27150923
41	MP0003186_abnormal_redox_activity	1.27075583
42	MP0005379_endocrine/exocrine_gland_phen	1.24446266
43	MP0005551_abnormal_eye_electrophysiolog	1.23232432
44	MP0001529_abnormal_vocalization	1.23028920
45	MP0003959_abnormal_lean_body	1.22578956
46	MP0005671_abnormal_response_to	1.21452454
47	MP0001485_abnormal_pinna_reflex	1.17391870
48	MP0002837_dystrophic_cardiac_calcinosis	1.13712299
49	MP0009333_abnormal_splenocyte_physiolog	1.13649377
50	MP0002067_abnormal_sensory_capabilities	1.13535403
51	MP0003123_paternal_imprinting	1.11826053
52	MP0001293_anophthalmia	1.10780191
53	MP0002876_abnormal_thyroid_physiology	1.10409793
54	MP0002277_abnormal_respiratory_mucosa	1.08355234
55	MP0005084_abnormal_gallbladder_morpholo	1.06158169
56	MP0002064_seizures	1.03107906
57	MP0003879_abnormal_hair_cell	1.02563045
58	MP0004924_abnormal_behavior	1.01420678
59	MP0005386_behavior/neurological_phenoty	1.01420678
60	MP0000049_abnormal_middle_ear	1.01064987
61	MP0004134_abnormal_chest_morphology	0.99856814
62	MP0000955_abnormal_spinal_cord	0.98940845
63	MP0004859_abnormal_synaptic_plasticity	0.97617766
64	MP0000534_abnormal_ureter_morphology	0.93343653
65	MP0000026_abnormal_inner_ear	0.90931404
66	MP0001919_abnormal_reproductive_system	0.90544785
67	MP0003938_abnormal_ear_development	0.88972473
68	MP0002752_abnormal_somatic_nervous	0.88259200
69	MP0004130_abnormal_muscle_cell	0.87708489
70	MP0003890_abnormal_embryonic-extraembry	0.87687998
71	MP0005646_abnormal_pituitary_gland	0.84699827
72	MP0000778_abnormal_nervous_system	0.84095226
73	MP0008789_abnormal_olfactory_epithelium	0.83088508
74	MP0004858_abnormal_nervous_system	0.81593901
75	MP0005389_reproductive_system_phenotype	0.81195856
76	MP0002938_white_spotting	0.79835843
77	MP0009046_muscle_twitch	0.79630289
78	MP0002234_abnormal_pharynx_morphology	0.78842419
79	MP0002909_abnormal_adrenal_gland	0.78644732
80	MP0009764_decreased_sensitivity_to	0.77892438
81	MP0000631_abnormal_neuroendocrine_gland	0.77531361
82	MP0005075_abnormal_melanosome_morpholog	0.77472314
83	MP0000516_abnormal_urinary_system	0.75918224
84	MP0005367_renal/urinary_system_phenotyp	0.75918224
85	MP0002735_abnormal_chemical_nociception	0.75202702
86	MP0001502_abnormal_circadian_rhythm	0.75163889
87	MP0005499_abnormal_olfactory_system	0.74819022
88	MP0005394_taste/olfaction_phenotype	0.74819022
89	MP0003195_calcinosis	0.73897824
90	MP0002882_abnormal_neuron_morphology	0.73794892
91	MP0000372_irregular_coat_pigmentation	0.70854705
92	MP0002095_abnormal_skin_pigmentation	0.69766472
93	MP0008995_early_reproductive_senescence	0.68948153
94	MP0001963_abnormal_hearing_physiology	0.68478201
95	MP0005670_abnormal_white_adipose	0.65703157
96	MP0002160_abnormal_reproductive_system	0.62839683
97	MP0005195_abnormal_posterior_eye	0.62699355
98	MP0003633_abnormal_nervous_system	0.62681283
99	MP0002066_abnormal_motor_capabilities/c	0.61447907
100	MP0001765_abnormal_ion_homeostasis	0.60568406

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.34924387
2	Stenosis of the external auditory canal (HP:0000402)	3.88123434
3	Acute necrotizing encephalopathy (HP:0006965)	3.77131499
4	Abnormality of cells of the erythroid lineage (HP:0012130)	3.71478780
5	Abnormality of midbrain morphology (HP:0002418)	3.54256836
6	Molar tooth sign on MRI (HP:0002419)	3.54256836
7	Increased hepatocellular lipid droplets (HP:0006565)	3.43065149
8	Homocystinuria (HP:0002156)	3.42435628
9	Abnormality of homocysteine metabolism (HP:0010919)	3.42435628
10	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.37519738
11	Progressive macrocephaly (HP:0004481)	3.30080951
12	Mitochondrial inheritance (HP:0001427)	3.29272317
13	Renal Fanconi syndrome (HP:0001994)	3.18621973
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.18566544
15	Methylmalonic acidemia (HP:0002912)	3.10687278
16	Nephronophthisis (HP:0000090)	3.07947374
17	Acute encephalopathy (HP:0006846)	3.07692915
18	Colon cancer (HP:0003003)	3.06124181
19	Abnormality of the labia minora (HP:0012880)	3.03055214
20	Macrocytic anemia (HP:0001972)	2.95131039
21	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.94201172
22	Abnormality of alanine metabolism (HP:0010916)	2.94201172
23	Hyperalaninemia (HP:0003348)	2.94201172
24	Lipid accumulation in hepatocytes (HP:0006561)	2.89995017
25	Pendular nystagmus (HP:0012043)	2.82460267
26	Increased CSF lactate (HP:0002490)	2.82137732
27	Exertional dyspnea (HP:0002875)	2.80365034
28	Abnormal number of erythroid precursors (HP:0012131)	2.76635866
29	Polyphagia (HP:0002591)	2.73987208
30	Type 2 muscle fiber atrophy (HP:0003554)	2.71945960
31	Congenital, generalized hypertrichosis (HP:0004540)	2.65580858
32	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.63745305
33	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.63369005
34	Abnormality of urine glucose concentration (HP:0011016)	2.62433957
35	Glycosuria (HP:0003076)	2.62433957
36	Bifid tongue (HP:0010297)	2.52912299
37	Hyperthyroidism (HP:0000836)	2.48279603
38	Agitation (HP:0000713)	2.46788788
39	Reticulocytopenia (HP:0001896)	2.43010230
40	Abnormal rod and cone electroretinograms (HP:0008323)	2.41572255
41	Increased intramyocellular lipid droplets (HP:0012240)	2.33374789
42	Oligomenorrhea (HP:0000876)	2.31721750
43	Pancreatic cysts (HP:0001737)	2.22270302
44	Pallor (HP:0000980)	2.22152367
45	Optic disc pallor (HP:0000543)	2.21996335
46	Cerebral edema (HP:0002181)	2.18443652
47	Abolished electroretinogram (ERG) (HP:0000550)	2.16333572
48	Abnormality of the renal medulla (HP:0100957)	2.16174722
49	Abnormality of renal resorption (HP:0011038)	2.15232721
50	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.14555179
51	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.14555179
52	Muscle fiber atrophy (HP:0100295)	2.13193965
53	Methylmalonic aciduria (HP:0012120)	2.12834489
54	Medial flaring of the eyebrow (HP:0010747)	2.12509965
55	Wide intermamillary distance (HP:0006610)	2.11950124
56	Abnormal pancreas size (HP:0012094)	2.05138965
57	Increased serum lactate (HP:0002151)	2.04059197
58	Concave nail (HP:0001598)	2.01990800
59	Labial hypoplasia (HP:0000066)	2.01194667
60	Abnormal ciliary motility (HP:0012262)	1.98374110
61	Sclerocornea (HP:0000647)	1.98245380
62	Morphological abnormality of the middle ear (HP:0008609)	1.97910129
63	Decreased muscle mass (HP:0003199)	1.95745381
64	Septo-optic dysplasia (HP:0100842)	1.90741507
65	X-linked dominant inheritance (HP:0001423)	1.88138156
66	Pancreatic fibrosis (HP:0100732)	1.87730579
67	Renal cortical cysts (HP:0000803)	1.87138586
68	Abnormality of vitamin B metabolism (HP:0004340)	1.86240155
69	Short tibia (HP:0005736)	1.86173358
70	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.85751493
71	Hypothermia (HP:0002045)	1.85516105
72	Absent thumb (HP:0009777)	1.85477959
73	Lactic acidosis (HP:0003128)	1.84963893
74	Epileptic encephalopathy (HP:0200134)	1.84699836
75	Sensory axonal neuropathy (HP:0003390)	1.84402003
76	Inability to walk (HP:0002540)	1.83557675
77	Abnormal respiratory motile cilium physiology (HP:0012261)	1.82243159
78	Anophthalmia (HP:0000528)	1.81939795
79	Exercise intolerance (HP:0003546)	1.81685971
80	Congenital stationary night blindness (HP:0007642)	1.81526851
81	Hepatic necrosis (HP:0002605)	1.81515671
82	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.80939940
83	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.80387694
84	Absent eyebrow (HP:0002223)	1.79838840
85	Keratoconus (HP:0000563)	1.79588942
86	Increased corneal curvature (HP:0100692)	1.79588942
87	Renal duplication (HP:0000075)	1.79437315
88	Myelomeningocele (HP:0002475)	1.78908269
89	Short chin (HP:0000331)	1.76300974
90	Narrow nasal bridge (HP:0000446)	1.75699867
91	Hepatocellular necrosis (HP:0001404)	1.75554652
92	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.75369214
93	Absent/shortened dynein arms (HP:0200106)	1.75369214
94	Absent septum pellucidum (HP:0001331)	1.75240001
95	Hypoplastic female external genitalia (HP:0012815)	1.75187731
96	Abnormality of the renal cortex (HP:0011035)	1.73699652
97	Elfin facies (HP:0004428)	1.73500857
98	Pachygyria (HP:0001302)	1.72888394
99	Supernumerary spleens (HP:0009799)	1.72087407
100	Increased muscle lipid content (HP:0009058)	1.70745823

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ADRBK2	4.75296666
2	PINK1	3.27194302
3	FRK	3.06697233
4	BCKDK	2.70273813
5	NME2	2.63476715
6	TXK	2.59313171
7	WNK4	2.48401746
8	PDK2	2.44059807
9	GRK1	2.43881108
10	PIK3CA	2.40065679
11	CAMKK2	2.39751077
12	MAP2K7	2.29789957
13	CDK19	2.26386061
14	MAP3K4	2.11623559
15	NUAK1	1.99610135
16	ZAK	1.77120463
17	DYRK2	1.72718031
18	VRK2	1.71425726
19	NTRK2	1.69063045
20	PRPF4B	1.67172582
21	PRKCG	1.65707897
22	EPHA4	1.56699453
23	TNIK	1.43298854
24	CASK	1.39850001
25	ILK	1.37092501
26	TAOK2	1.37021438
27	SGK494	1.33868171
28	SGK223	1.33868171
29	WNK3	1.30397328
30	SGK3	1.23750917
31	MAPK13	1.19948070
32	MARK1	1.18925397
33	AKT3	1.16169933
34	PHKG1	1.16058557
35	PHKG2	1.16058557
36	MUSK	1.09560085
37	PRKCH	1.06319505
38	NTRK3	1.03941254
39	ADRBK1	1.02250747
40	PIK3CG	0.97649943
41	DYRK3	0.94889448
42	ITK	0.93807004
43	SGK2	0.91697807
44	KIT	0.87324455
45	MINK1	0.78173068
46	CAMK2A	0.76952983
47	INSRR	0.75285485
48	MAP4K2	0.72598515
49	BRSK2	0.71662004
50	VRK1	0.69913419
51	CAMK1	0.68792016
52	MAP2K4	0.68430948
53	IRAK2	0.67348731
54	LIMK1	0.65128868
55	PAK3	0.65117547
56	ERBB3	0.64983337
57	PRKACA	0.61819730
58	MKNK2	0.59693684
59	CSNK2A2	0.59478079
60	SGK1	0.57950342
61	PRKCE	0.57283228
62	CAMK2D	0.54498919
63	CAMKK1	0.54406614
64	BCR	0.53127023
65	PKN1	0.51739452
66	DYRK1A	0.50014096
67	FGFR2	0.49845987
68	CSNK1E	0.49212652
69	DAPK2	0.48765717
70	RPS6KA1	0.48489034
71	PLK4	0.48461834
72	OBSCN	0.47565700
73	TIE1	0.47550120
74	EIF2AK1	0.47444385
75	PLK3	0.46444976
76	PRKCQ	0.45853660
77	NLK	0.45453785
78	KDR	0.45252179
79	PNCK	0.44461780
80	PRKACG	0.43452193
81	ABL2	0.42044443
82	PRKCD	0.41489964
83	NEK1	0.40528903
84	PRKCA	0.39524012
85	MAPK15	0.38430549
86	CSNK2A1	0.37900666
87	BMPR1B	0.37436757
88	PBK	0.37052468
89	MAP3K6	0.36878739
90	CSNK1G1	0.36802614
91	SIK2	0.35541013
92	DAPK1	0.34652986
93	MYLK	0.33876803
94	PRKCB	0.33807077
95	MAP3K12	0.33767419
96	SYK	0.32482535
97	LRRK2	0.31848105
98	CHEK2	0.31566355
99	CSNK1A1	0.30652029
100	PAK6	0.30406708

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.58365894
2	Ribosome_Homo sapiens_hsa03010	4.49437647
3	Parkinsons disease_Homo sapiens_hsa05012	3.80489378
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.41933734
5	Cardiac muscle contraction_Homo sapiens_hsa04260	3.41228102
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.34019767
7	Alzheimers disease_Homo sapiens_hsa05010	2.73667269
8	Huntingtons disease_Homo sapiens_hsa05016	2.58300412
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.57940651
10	Folate biosynthesis_Homo sapiens_hsa00790	2.36926276
11	One carbon pool by folate_Homo sapiens_hsa00670	2.20929403
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.11343228
13	Protein export_Homo sapiens_hsa03060	2.01565751
14	Steroid biosynthesis_Homo sapiens_hsa00100	1.95720830
15	RNA polymerase_Homo sapiens_hsa03020	1.87004677
16	Butanoate metabolism_Homo sapiens_hsa00650	1.74678405
17	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.70538791
18	Nicotine addiction_Homo sapiens_hsa05033	1.70473878
19	Allograft rejection_Homo sapiens_hsa05330	1.67184078
20	Asthma_Homo sapiens_hsa05310	1.63314546
21	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.55557856
22	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.54920640
23	Morphine addiction_Homo sapiens_hsa05032	1.51875797
24	Proteasome_Homo sapiens_hsa03050	1.50360294
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.44475337
26	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.39338254
27	Taste transduction_Homo sapiens_hsa04742	1.38043918
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.37552440
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34000499
30	Fat digestion and absorption_Homo sapiens_hsa04975	1.20578926
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.18058564
32	GABAergic synapse_Homo sapiens_hsa04727	1.17335448
33	Phototransduction_Homo sapiens_hsa04744	1.11090604
34	Basal transcription factors_Homo sapiens_hsa03022	1.10556644
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08090136
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.06513605
37	Caffeine metabolism_Homo sapiens_hsa00232	1.04747361
38	Type I diabetes mellitus_Homo sapiens_hsa04940	0.96361928
39	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.92539374
40	Serotonergic synapse_Homo sapiens_hsa04726	0.89124686
41	Ether lipid metabolism_Homo sapiens_hsa00565	0.89088532
42	Pyruvate metabolism_Homo sapiens_hsa00620	0.86495321
43	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.84861635
44	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.84113621
45	Graft-versus-host disease_Homo sapiens_hsa05332	0.83504476
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.82607431
47	Propanoate metabolism_Homo sapiens_hsa00640	0.76567609
48	Nitrogen metabolism_Homo sapiens_hsa00910	0.76531178
49	Homologous recombination_Homo sapiens_hsa03440	0.74483296
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.72548401
51	Dopaminergic synapse_Homo sapiens_hsa04728	0.71928249
52	Spliceosome_Homo sapiens_hsa03040	0.71642661
53	Purine metabolism_Homo sapiens_hsa00230	0.69724802
54	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.67469561
55	Regulation of autophagy_Homo sapiens_hsa04140	0.66675801
56	Glutamatergic synapse_Homo sapiens_hsa04724	0.65011137
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.64563636
58	Peroxisome_Homo sapiens_hsa04146	0.63013205
59	Rheumatoid arthritis_Homo sapiens_hsa05323	0.62886803
60	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.60687923
61	Primary immunodeficiency_Homo sapiens_hsa05340	0.60546980
62	Circadian entrainment_Homo sapiens_hsa04713	0.58119405
63	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.57534449
64	Fatty acid elongation_Homo sapiens_hsa00062	0.56981616
65	Olfactory transduction_Homo sapiens_hsa04740	0.54943857
66	Metabolic pathways_Homo sapiens_hsa01100	0.54174893
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53365521
68	Fanconi anemia pathway_Homo sapiens_hsa03460	0.51658390
69	RNA degradation_Homo sapiens_hsa03018	0.51265793
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.50080310
71	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.49025389
72	Tryptophan metabolism_Homo sapiens_hsa00380	0.47214552
73	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.47066390
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.46907405
75	RNA transport_Homo sapiens_hsa03013	0.44297716
76	Nucleotide excision repair_Homo sapiens_hsa03420	0.40409924
77	Cholinergic synapse_Homo sapiens_hsa04725	0.39993016
78	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.37052746
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.36904024
80	Insulin secretion_Homo sapiens_hsa04911	0.36403237
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.33318441
82	Retinol metabolism_Homo sapiens_hsa00830	0.33031353
83	Collecting duct acid secretion_Homo sapiens_hsa04966	0.32563266
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.31459910
85	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.28760975
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.25054823
87	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.23483859
88	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.21692872
89	Ras signaling pathway_Homo sapiens_hsa04014	0.21403931
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.20541985
91	Phenylalanine metabolism_Homo sapiens_hsa00360	0.20231216
92	Fatty acid degradation_Homo sapiens_hsa00071	0.19664936
93	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.18833667
94	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.16563375
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.14309462
96	Base excision repair_Homo sapiens_hsa03410	0.12714535
97	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.11343836
98	Amphetamine addiction_Homo sapiens_hsa05031	0.08582635
99	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.08136869
100	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.07436361

ATP5JP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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