ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.28188394
2	fucose catabolic process (GO:0019317)	5.51496205
3	L-fucose metabolic process (GO:0042354)	5.51496205
4	L-fucose catabolic process (GO:0042355)	5.51496205
5	histone mRNA catabolic process (GO:0071044)	4.27454682
6	detection of light stimulus involved in sensory perception (GO:0050962)	3.87813832
7	detection of light stimulus involved in visual perception (GO:0050908)	3.87813832
8	indolalkylamine metabolic process (GO:0006586)	3.77768188
9	DNA deamination (GO:0045006)	3.76864104
10	indole-containing compound catabolic process (GO:0042436)	3.75112129
11	indolalkylamine catabolic process (GO:0046218)	3.75112129
12	tryptophan catabolic process (GO:0006569)	3.75112129
13	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.68068264
14	piRNA metabolic process (GO:0034587)	3.66660898
15	prenylation (GO:0097354)	3.60591232
16	protein prenylation (GO:0018342)	3.60591232
17	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.56047189
18	kynurenine metabolic process (GO:0070189)	3.55123631
19	water-soluble vitamin biosynthetic process (GO:0042364)	3.54649540
20	protein localization to cilium (GO:0061512)	3.42159800
21	cornea development in camera-type eye (GO:0061303)	3.38555978
22	protein-cofactor linkage (GO:0018065)	3.38552345
23	fat-soluble vitamin catabolic process (GO:0042363)	3.37425995
24	vitamin catabolic process (GO:0009111)	3.37425995
25	snRNA processing (GO:0016180)	3.35914635
26	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.35411360
27	behavioral response to ethanol (GO:0048149)	3.35367737
28	cellular ketone body metabolic process (GO:0046950)	3.21256838
29	pseudouridine synthesis (GO:0001522)	3.21119537
30	cellular response to ATP (GO:0071318)	3.19418063
31	mRNA cleavage (GO:0006379)	3.19281174
32	tryptophan metabolic process (GO:0006568)	3.14214901
33	negative regulation of telomere maintenance (GO:0032205)	3.13081778
34	negative regulation of mast cell activation (GO:0033004)	3.12222605
35	nonmotile primary cilium assembly (GO:0035058)	3.11527580
36	response to pheromone (GO:0019236)	3.10013904
37	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.06662441
38	axoneme assembly (GO:0035082)	3.05100672
39	epithelial cilium movement (GO:0003351)	3.00433265
40	DNA methylation involved in gamete generation (GO:0043046)	2.98835431
41	regulation of neurotransmitter uptake (GO:0051580)	2.96068261
42	protein import into peroxisome matrix (GO:0016558)	2.95402013
43	regulation of action potential (GO:0098900)	2.95349136
44	ketone body metabolic process (GO:1902224)	2.91898846
45	fucosylation (GO:0036065)	2.90213648
46	rRNA catabolic process (GO:0016075)	2.89746539
47	cAMP catabolic process (GO:0006198)	2.89348325
48	maturation of 5.8S rRNA (GO:0000460)	2.89214050
49	indole-containing compound metabolic process (GO:0042430)	2.86969990
50	exogenous drug catabolic process (GO:0042738)	2.84284496
51	neuronal action potential (GO:0019228)	2.83519206
52	reflex (GO:0060004)	2.80192700
53	histone mRNA metabolic process (GO:0008334)	2.79824162
54	drug catabolic process (GO:0042737)	2.79296102
55	snRNA metabolic process (GO:0016073)	2.78761395
56	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.77481671
57	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.77481671
58	NADH dehydrogenase complex assembly (GO:0010257)	2.77481671
59	regulation of hippo signaling (GO:0035330)	2.77163141
60	kidney morphogenesis (GO:0060993)	2.76481380
61	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.75284251
62	preassembly of GPI anchor in ER membrane (GO:0016254)	2.74175578
63	adaptation of signaling pathway (GO:0023058)	2.74151713
64	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.73106140
65	coenzyme catabolic process (GO:0009109)	2.71821333
66	tRNA modification (GO:0006400)	2.70198244
67	protein complex biogenesis (GO:0070271)	2.68829720
68	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.68474053
69	reciprocal meiotic recombination (GO:0007131)	2.65359203
70	reciprocal DNA recombination (GO:0035825)	2.65359203
71	ubiquinone biosynthetic process (GO:0006744)	2.65189514
72	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.65042866
73	platelet dense granule organization (GO:0060155)	2.64008767
74	tRNA processing (GO:0008033)	2.63614913
75	auditory behavior (GO:0031223)	2.63237809
76	basic amino acid transport (GO:0015802)	2.61094015
77	protein polyglutamylation (GO:0018095)	2.60941049
78	rhodopsin mediated signaling pathway (GO:0016056)	2.60526058
79	auditory receptor cell stereocilium organization (GO:0060088)	2.60062364
80	photoreceptor cell development (GO:0042461)	2.59919320
81	neural tube formation (GO:0001841)	2.59103635
82	positive regulation of fatty acid transport (GO:2000193)	2.58749714
83	cyclic nucleotide catabolic process (GO:0009214)	2.58319626
84	primary amino compound metabolic process (GO:1901160)	2.57670835
85	respiratory chain complex IV assembly (GO:0008535)	2.56990954
86	sulfation (GO:0051923)	2.56668931
87	protein K11-linked deubiquitination (GO:0035871)	2.56172249
88	regulation of cilium movement (GO:0003352)	2.56127037
89	multicellular organism reproduction (GO:0032504)	2.55596432
90	cellular biogenic amine catabolic process (GO:0042402)	2.54767089
91	amine catabolic process (GO:0009310)	2.54767089
92	glycerophospholipid catabolic process (GO:0046475)	2.53640561
93	regulation of mesoderm development (GO:2000380)	2.52279645
94	mitochondrial respiratory chain complex assembly (GO:0033108)	2.51760890
95	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.51235717
96	positive regulation of defense response to virus by host (GO:0002230)	2.51125069
97	membrane depolarization during action potential (GO:0086010)	2.50794021
98	C4-dicarboxylate transport (GO:0015740)	2.48173031
99	ubiquinone metabolic process (GO:0006743)	2.47253678
100	protein neddylation (GO:0045116)	2.47083269

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.43461831
2	VDR_22108803_ChIP-Seq_LS180_Human	3.60918823
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.72894239
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.46681934
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.40545231
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.38162502
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.28438817
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.16649911
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.13152725
10	EWS_26573619_Chip-Seq_HEK293_Human	2.03942043
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.94960689
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.94766142
13	TP53_22573176_ChIP-Seq_HFKS_Human	1.92576881
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91364783
15	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.90765618
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89085274
17	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.81632604
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.81401218
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.80138344
20	P300_19829295_ChIP-Seq_ESCs_Human	1.79794403
21	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.72140847
22	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.68576232
23	FUS_26573619_Chip-Seq_HEK293_Human	1.68563482
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.68180623
25	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.63559216
26	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.62845706
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.56849484
28	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.56656183
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.55340936
30	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.52939085
31	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.52939085
32	REST_21632747_ChIP-Seq_MESCs_Mouse	1.52202513
33	STAT3_23295773_ChIP-Seq_U87_Human	1.50528204
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.47169007
35	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.45591543
36	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.44489350
37	TCF4_23295773_ChIP-Seq_U87_Human	1.43526081
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.39847135
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.39677597
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.39429451
41	NCOR_22424771_ChIP-Seq_293T_Human	1.38616593
42	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.37958362
43	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.35398828
44	AR_20517297_ChIP-Seq_VCAP_Human	1.35265026
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.33638779
46	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.32437086
47	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.32368758
48	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32181473
49	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.30454029
50	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.28628804
51	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28628804
52	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.28568580
53	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.27758969
54	ERA_21632823_ChIP-Seq_H3396_Human	1.26259750
55	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26041251
56	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.25556212
57	AR_21572438_ChIP-Seq_LNCaP_Human	1.24961898
58	CBP_20019798_ChIP-Seq_JUKART_Human	1.24340481
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.24340481
60	HOXB7_26014856_ChIP-Seq_BT474_Human	1.23623888
61	AR_25329375_ChIP-Seq_VCAP_Human	1.23582309
62	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.21205869
63	VDR_23849224_ChIP-Seq_CD4+_Human	1.20877533
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.20225131
65	SMAD4_21799915_ChIP-Seq_A2780_Human	1.19928471
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.19915601
67	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.19638726
68	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.19491211
69	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18037470
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18037470
71	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.16727652
72	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14888118
73	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14201971
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13797535
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12989796
76	TAF2_19829295_ChIP-Seq_ESCs_Human	1.12220626
77	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.11856224
78	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.11272875
79	* P53_21459846_ChIP-Seq_SAOS-2_Human	1.09348672
80	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.09240784
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07471472
82	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06836514
83	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.06371082
84	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.05661214
85	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.05375763
86	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.03744585
87	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.03263492
88	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.01867512
89	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.01320467
90	NANOG_20526341_ChIP-Seq_ESCs_Human	1.01249898
91	* GATA3_26560356_Chip-Seq_TH2_Human	0.99975153
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99269776
93	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.99183339
94	* MYC_19829295_ChIP-Seq_ESCs_Human	0.99121624
95	OCT4_20526341_ChIP-Seq_ESCs_Human	0.98870905
96	RNF2_27304074_Chip-Seq_NSC_Mouse	0.98450072
97	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98404540
98	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.98374682
99	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98346047
100	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.97682770

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.00646151
2	MP0008877_abnormal_DNA_methylation	2.90898754
3	MP0003787_abnormal_imprinting	2.89871540
4	MP0003646_muscle_fatigue	2.80510935
5	MP0004043_abnormal_pH_regulation	2.77660519
6	MP0006292_abnormal_olfactory_placode	2.51367595
7	MP0005645_abnormal_hypothalamus_physiol	2.44467511
8	MP0005551_abnormal_eye_electrophysiolog	2.41434460
9	MP0001968_abnormal_touch/_nociception	2.27748245
10	MP0000569_abnormal_digit_pigmentation	2.17824683
11	MP0001986_abnormal_taste_sensitivity	2.15616952
12	MP0003195_calcinosis	2.15524891
13	MP0002876_abnormal_thyroid_physiology	2.11092421
14	MP0004147_increased_porphyrin_level	2.06870212
15	MP0009745_abnormal_behavioral_response	2.05789772
16	MP0008872_abnormal_physiological_respon	2.00485031
17	MP0002638_abnormal_pupillary_reflex	2.00344221
18	MP0009046_muscle_twitch	1.89380718
19	MP0002837_dystrophic_cardiac_calcinosis	1.87833372
20	MP0004885_abnormal_endolymph	1.87094889
21	MP0004142_abnormal_muscle_tone	1.84253322
22	MP0005646_abnormal_pituitary_gland	1.82248524
23	MP0002736_abnormal_nociception_after	1.79108108
24	MP0008875_abnormal_xenobiotic_pharmacok	1.76246157
25	MP0002653_abnormal_ependyma_morphology	1.72829891
26	MP0000427_abnormal_hair_cycle	1.68625823
27	MP0001501_abnormal_sleep_pattern	1.68058597
28	MP0005084_abnormal_gallbladder_morpholo	1.65386551
29	MP0002938_white_spotting	1.59867740
30	MP0002272_abnormal_nervous_system	1.59693219
31	MP0002572_abnormal_emotion/affect_behav	1.44028565
32	MP0000372_irregular_coat_pigmentation	1.38230920
33	MP0001485_abnormal_pinna_reflex	1.37384052
34	MP0002160_abnormal_reproductive_system	1.36881549
35	MP0002064_seizures	1.35059729
36	MP0002557_abnormal_social/conspecific_i	1.32952858
37	MP0001970_abnormal_pain_threshold	1.32466652
38	MP0006276_abnormal_autonomic_nervous	1.31314173
39	MP0004145_abnormal_muscle_electrophysio	1.30896015
40	MP0005389_reproductive_system_phenotype	1.30371519
41	MP0002733_abnormal_thermal_nociception	1.30076350
42	MP0005253_abnormal_eye_physiology	1.30036111
43	MP0000631_abnormal_neuroendocrine_gland	1.28631707
44	MP0001984_abnormal_olfaction	1.27735649
45	MP0001486_abnormal_startle_reflex	1.27639003
46	MP0002909_abnormal_adrenal_gland	1.25135714
47	MP0004133_heterotaxia	1.25079873
48	MP0005167_abnormal_blood-brain_barrier	1.20838162
49	MP0003718_maternal_effect	1.20084701
50	MP0002234_abnormal_pharynx_morphology	1.19980631
51	MP0006072_abnormal_retinal_apoptosis	1.19430967
52	MP0005379_endocrine/exocrine_gland_phen	1.17860971
53	MP0001919_abnormal_reproductive_system	1.17497631
54	MP0001529_abnormal_vocalization	1.17040189
55	MP0002138_abnormal_hepatobiliary_system	1.15546315
56	MP0004742_abnormal_vestibular_system	1.14701287
57	MP0002063_abnormal_learning/memory/cond	1.14694466
58	MP0000383_abnormal_hair_follicle	1.14619369
59	MP0005174_abnormal_tail_pigmentation	1.14208995
60	MP0005377_hearing/vestibular/ear_phenot	1.12000814
61	MP0003878_abnormal_ear_physiology	1.12000814
62	MP0002928_abnormal_bile_duct	1.11449616
63	MP0003121_genomic_imprinting	1.10929747
64	MP0002163_abnormal_gland_morphology	1.10147673
65	MP0003011_delayed_dark_adaptation	1.09253240
66	MP0008775_abnormal_heart_ventricle	1.04151297
67	MP0003635_abnormal_synaptic_transmissio	1.03019485
68	MP0004924_abnormal_behavior	1.01336104
69	MP0005386_behavior/neurological_phenoty	1.01336104
70	MP0001502_abnormal_circadian_rhythm	0.99479612
71	MP0002095_abnormal_skin_pigmentation	0.97300569
72	MP0005332_abnormal_amino_acid	0.95265378
73	MP0005360_urolithiasis	0.94803429
74	MP0002735_abnormal_chemical_nociception	0.94465150
75	MP0009764_decreased_sensitivity_to	0.94207204
76	MP0001905_abnormal_dopamine_level	0.94031207
77	MP0002693_abnormal_pancreas_physiology	0.93379756
78	MP0002067_abnormal_sensory_capabilities	0.93114642
79	MP0001188_hyperpigmentation	0.93076894
80	MP0005195_abnormal_posterior_eye	0.92740966
81	MP0005410_abnormal_fertilization	0.91778565
82	MP0003119_abnormal_digestive_system	0.91220975
83	MP0002184_abnormal_innervation	0.89851462
84	MP0008789_abnormal_olfactory_epithelium	0.89329664
85	MP0000015_abnormal_ear_pigmentation	0.88354627
86	MP0002229_neurodegeneration	0.86196192
87	MP0000230_abnormal_systemic_arterial	0.85346847
88	MP0002734_abnormal_mechanical_nocicepti	0.83752670
89	MP0003880_abnormal_central_pattern	0.83387512
90	MP0002752_abnormal_somatic_nervous	0.83335140
91	MP0003698_abnormal_male_reproductive	0.82317618
92	MP0001944_abnormal_pancreas_morphology	0.82215686
93	MP0008058_abnormal_DNA_repair	0.82182451
94	MP0001664_abnormal_digestion	0.81836863
95	MP0000026_abnormal_inner_ear	0.81312067
96	MP0005671_abnormal_response_to	0.80488769
97	MP0002822_catalepsy	0.79951375
98	MP0000647_abnormal_sebaceous_gland	0.77694650
99	MP0010386_abnormal_urinary_bladder	0.76022871
100	MP0003567_abnormal_fetal_cardiomyocyte	0.75330563

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	5.02068825
2	Abnormality of alanine metabolism (HP:0010916)	4.64177427
3	Hyperalaninemia (HP:0003348)	4.64177427
4	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.64177427
5	Pancreatic cysts (HP:0001737)	4.23678814
6	Abnormal drinking behavior (HP:0030082)	3.78472970
7	Polydipsia (HP:0001959)	3.78472970
8	Abnormality of midbrain morphology (HP:0002418)	3.59805567
9	Molar tooth sign on MRI (HP:0002419)	3.59805567
10	Pancreatic fibrosis (HP:0100732)	3.54443188
11	Hyperventilation (HP:0002883)	3.48571887
12	Decreased circulating renin level (HP:0003351)	3.36502044
13	Abnormal rod and cone electroretinograms (HP:0008323)	3.31696724
14	Attenuation of retinal blood vessels (HP:0007843)	3.29334478
15	Type II lissencephaly (HP:0007260)	3.27968077
16	Abnormality of the renal cortex (HP:0011035)	3.26637550
17	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.04946429
18	Absent/shortened dynein arms (HP:0200106)	3.04946429
19	Nephronophthisis (HP:0000090)	3.04717007
20	True hermaphroditism (HP:0010459)	3.00773635
21	Polyuria (HP:0000103)	2.89284827
22	Tubular atrophy (HP:0000092)	2.85596510
23	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.83644745
24	Hypoplasia of the fovea (HP:0007750)	2.83644745
25	Decreased central vision (HP:0007663)	2.80027111
26	Abolished electroretinogram (ERG) (HP:0000550)	2.79489930
27	Pendular nystagmus (HP:0012043)	2.73145038
28	Febrile seizures (HP:0002373)	2.72510648
29	Abnormality of the renal medulla (HP:0100957)	2.67127871
30	Inability to walk (HP:0002540)	2.58526626
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.58256399
32	Medial flaring of the eyebrow (HP:0010747)	2.54757192
33	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.52328722
34	Increased corneal curvature (HP:0100692)	2.50467010
35	Keratoconus (HP:0000563)	2.50467010
36	Cystic liver disease (HP:0006706)	2.49984017
37	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.45911526
38	Progressive inability to walk (HP:0002505)	2.39325949
39	Lissencephaly (HP:0001339)	2.35150065
40	Abnormal urine output (HP:0012590)	2.32031416
41	Abnormal respiratory motile cilium morphology (HP:0005938)	2.29148503
42	Abnormal respiratory epithelium morphology (HP:0012253)	2.29148503
43	Renal cortical cysts (HP:0000803)	2.27321613
44	Ketoacidosis (HP:0001993)	2.25883213
45	Tachypnea (HP:0002789)	2.23870529
46	Abnormality of the fovea (HP:0000493)	2.21737362
47	Chronic hepatic failure (HP:0100626)	2.19507334
48	Hypoplasia of the uterus (HP:0000013)	2.15016722
49	Aplasia/hypoplasia of the uterus (HP:0008684)	2.13320724
50	Broad-based gait (HP:0002136)	2.11436594
51	Polyphagia (HP:0002591)	2.09546226
52	Ketosis (HP:0001946)	2.09226482
53	Concave nail (HP:0001598)	2.06084960
54	Alkalosis (HP:0001948)	2.06070058
55	Abnormality of renal excretion (HP:0011036)	2.04204756
56	Protruding tongue (HP:0010808)	2.02234753
57	Sclerocornea (HP:0000647)	2.02169706
58	Abnormality of renin-angiotensin system (HP:0000847)	2.01726268
59	Bilateral microphthalmos (HP:0007633)	1.99801542
60	Hypomagnesemia (HP:0002917)	1.99790871
61	Severe muscular hypotonia (HP:0006829)	1.98194469
62	Chorioretinal atrophy (HP:0000533)	1.97354847
63	Bile duct proliferation (HP:0001408)	1.97300131
64	Abnormal biliary tract physiology (HP:0012439)	1.97300131
65	Gait imbalance (HP:0002141)	1.96743544
66	Large for gestational age (HP:0001520)	1.93278490
67	Bony spicule pigmentary retinopathy (HP:0007737)	1.93140140
68	Progressive cerebellar ataxia (HP:0002073)	1.92469265
69	Hypoplasia of the pons (HP:0012110)	1.91670307
70	Methylmalonic aciduria (HP:0012120)	1.91393872
71	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.91220058
72	Pachygyria (HP:0001302)	1.90304825
73	Thyroid-stimulating hormone excess (HP:0002925)	1.90093907
74	Gaze-evoked nystagmus (HP:0000640)	1.89857233
75	Optic disc pallor (HP:0000543)	1.88681875
76	Congenital, generalized hypertrichosis (HP:0004540)	1.87318002
77	Anencephaly (HP:0002323)	1.87123283
78	Abnormality of the pons (HP:0007361)	1.86964680
79	Small hand (HP:0200055)	1.85722014
80	Brushfield spots (HP:0001088)	1.85612186
81	Asplenia (HP:0001746)	1.85467818
82	Abnormality of macular pigmentation (HP:0008002)	1.85191351
83	Congenital primary aphakia (HP:0007707)	1.83185204
84	Cerebellar dysplasia (HP:0007033)	1.82776060
85	Stomatitis (HP:0010280)	1.82433732
86	Acute necrotizing encephalopathy (HP:0006965)	1.82271455
87	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.82039963
88	Optic nerve hypoplasia (HP:0000609)	1.80799095
89	Increased serum lactate (HP:0002151)	1.80426934
90	Metabolic alkalosis (HP:0200114)	1.79320868
91	Constricted visual fields (HP:0001133)	1.79257392
92	Increased CSF lactate (HP:0002490)	1.75781848
93	Oral leukoplakia (HP:0002745)	1.75192154
94	Supernumerary spleens (HP:0009799)	1.75169016
95	Hypothermia (HP:0002045)	1.74492834
96	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.73535973
97	Clumsiness (HP:0002312)	1.71540751
98	Abnormal ciliary motility (HP:0012262)	1.71354725
99	Furrowed tongue (HP:0000221)	1.70520485
100	Retinal dysplasia (HP:0007973)	1.70486244

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ADRBK2	4.85155028
2	FRK	4.27829446
3	TLK1	4.19191876
4	WNK4	3.39183209
5	DAPK2	3.37807276
6	MAP4K2	2.94568647
7	BMPR1B	2.84978976
8	GRK1	2.64945926
9	ZAK	2.37899388
10	TAOK3	2.29157834
11	ACVR1B	2.23808448
12	NUAK1	2.16480466
13	WNK3	1.96967482
14	PINK1	1.95701731
15	MAPK13	1.84968114
16	INSRR	1.56917264
17	MAP3K4	1.54726099
18	TXK	1.50902197
19	TIE1	1.38483127
20	OXSR1	1.37801752
21	CASK	1.33394216
22	STK39	1.31724031
23	ADRBK1	1.30579867
24	MARK1	1.28772458
25	CAMKK2	1.17979573
26	MKNK2	1.14140619
27	PAK3	1.14063363
28	MAP2K6	1.13483702
29	IRAK1	1.08303694
30	PRKCG	1.02713304
31	DYRK2	1.01815605
32	CSNK1G2	0.98539448
33	MAPKAPK3	0.98287478
34	NTRK3	0.95619449
35	PHKG2	0.92647604
36	PHKG1	0.92647604
37	PRKCE	0.91426508
38	BCKDK	0.85071926
39	STK38L	0.82608426
40	CSNK1G3	0.82017929
41	TRIM28	0.81058131
42	PRKCI	0.80941517
43	PTK2B	0.80573044
44	MAP2K7	0.76581140
45	TGFBR1	0.76400300
46	PIK3CA	0.76182909
47	CSNK1G1	0.75472264
48	VRK1	0.71218436
49	PLK2	0.69092945
50	PRKCQ	0.69016219
51	CSNK1A1L	0.67212332
52	SYK	0.65584167
53	CAMK2A	0.65489508
54	TEC	0.65275599
55	ATR	0.64911499
56	IKBKB	0.64376404
57	NTRK2	0.62986387
58	TNIK	0.62643882
59	RPS6KA5	0.62217248
60	TRPM7	0.60979002
61	BRSK2	0.59680826
62	PKN1	0.58324565
63	CAMK1	0.58079680
64	MAP4K1	0.55765603
65	FLT3	0.53713807
66	CSNK1A1	0.50924652
67	CDK19	0.50886444
68	MAPKAPK5	0.49662587
69	SIK2	0.48814724
70	STK3	0.48672713
71	VRK2	0.48656639
72	RPS6KA6	0.47947363
73	ITK	0.46936761
74	LIMK1	0.43769817
75	PRKCZ	0.43442736
76	MUSK	0.43273744
77	CHEK2	0.43194028
78	PRKACA	0.43007005
79	CAMK4	0.42005492
80	FGFR2	0.37522711
81	STK11	0.37323446
82	MKNK1	0.36150792
83	TNK2	0.35612442
84	NEK2	0.34910692
85	TAF1	0.34625626
86	STK16	0.33277202
87	CAMKK1	0.32777912
88	CSNK1D	0.32393571
89	PRKCA	0.31831022
90	PRKG1	0.31666545
91	PRKAA2	0.28676360
92	TYRO3	0.28412081
93	TSSK6	0.27810332
94	KIT	0.26411374
95	PRKAA1	0.25638822
96	WNK1	0.24457104
97	CDK3	0.24169712
98	PLK3	0.23870580
99	IGF1R	0.23636417
100	ERBB3	0.23536184

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	3.18734903
2	Phototransduction_Homo sapiens_hsa04744	2.66628247
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.64912852
4	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.56671127
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.37038015
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.36106163
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.22042554
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.16549073
9	Nicotine addiction_Homo sapiens_hsa05033	2.11112587
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.10540280
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.06237363
12	Selenocompound metabolism_Homo sapiens_hsa00450	2.05855605
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.04943653
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.93158263
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.91912132
16	RNA polymerase_Homo sapiens_hsa03020	1.84758818
17	Butanoate metabolism_Homo sapiens_hsa00650	1.84474052
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.78388842
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.77694551
20	Homologous recombination_Homo sapiens_hsa03440	1.76432312
21	Basal transcription factors_Homo sapiens_hsa03022	1.73437696
22	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.70292355
23	Caffeine metabolism_Homo sapiens_hsa00232	1.67181327
24	Morphine addiction_Homo sapiens_hsa05032	1.59666924
25	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.57512003
26	One carbon pool by folate_Homo sapiens_hsa00670	1.54994940
27	Olfactory transduction_Homo sapiens_hsa04740	1.52411201
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.47526385
29	Parkinsons disease_Homo sapiens_hsa05012	1.46410527
30	Taste transduction_Homo sapiens_hsa04742	1.43299987
31	Asthma_Homo sapiens_hsa05310	1.41130244
32	Protein export_Homo sapiens_hsa03060	1.39117619
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.36074156
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.30908845
35	Histidine metabolism_Homo sapiens_hsa00340	1.23356732
36	Insulin secretion_Homo sapiens_hsa04911	1.18499468
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.18137423
38	RNA degradation_Homo sapiens_hsa03018	1.14552560
39	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.14207716
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.14108547
41	Sulfur relay system_Homo sapiens_hsa04122	1.14061522
42	Circadian entrainment_Homo sapiens_hsa04713	1.13623143
43	Fanconi anemia pathway_Homo sapiens_hsa03460	1.12639608
44	Sulfur metabolism_Homo sapiens_hsa00920	1.12542153
45	GABAergic synapse_Homo sapiens_hsa04727	1.10807870
46	Alzheimers disease_Homo sapiens_hsa05010	1.10517938
47	Peroxisome_Homo sapiens_hsa04146	1.10433985
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.07591485
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.06662994
50	Serotonergic synapse_Homo sapiens_hsa04726	0.98245232
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.97486061
52	Huntingtons disease_Homo sapiens_hsa05016	0.94613513
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.89805913
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.87468123
55	Propanoate metabolism_Homo sapiens_hsa00640	0.84860786
56	Glutamatergic synapse_Homo sapiens_hsa04724	0.82099598
57	ABC transporters_Homo sapiens_hsa02010	0.81890747
58	Salivary secretion_Homo sapiens_hsa04970	0.81316872
59	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.79920244
60	Retinol metabolism_Homo sapiens_hsa00830	0.79355948
61	Calcium signaling pathway_Homo sapiens_hsa04020	0.74098952
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73884710
63	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.72562535
64	Collecting duct acid secretion_Homo sapiens_hsa04966	0.72255626
65	Purine metabolism_Homo sapiens_hsa00230	0.70736906
66	Primary immunodeficiency_Homo sapiens_hsa05340	0.68448532
67	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.67451930
68	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67435305
69	Regulation of autophagy_Homo sapiens_hsa04140	0.65275807
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64012232
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61929327
72	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.61091650
73	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.60977411
74	Ribosome_Homo sapiens_hsa03010	0.60481773
75	Type I diabetes mellitus_Homo sapiens_hsa04940	0.59477353
76	Metabolic pathways_Homo sapiens_hsa01100	0.58629301
77	Dopaminergic synapse_Homo sapiens_hsa04728	0.58561549
78	Pyrimidine metabolism_Homo sapiens_hsa00240	0.57176899
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.56773517
80	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.55360513
81	Allograft rejection_Homo sapiens_hsa05330	0.55093666
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.52331692
83	Graft-versus-host disease_Homo sapiens_hsa05332	0.51509500
84	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.50006101
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49399594
86	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.47735390
87	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47461528
88	Mineral absorption_Homo sapiens_hsa04978	0.46727868
89	Steroid biosynthesis_Homo sapiens_hsa00100	0.40122213
90	Cholinergic synapse_Homo sapiens_hsa04725	0.39646572
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37215637
92	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.36435338
93	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.34696576
94	Cocaine addiction_Homo sapiens_hsa05030	0.32571985
95	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.32283067
96	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.31953549
97	cAMP signaling pathway_Homo sapiens_hsa04024	0.31552258
98	Lysine degradation_Homo sapiens_hsa00310	0.27806806
99	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.27191727
100	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.26109992

ATP5L2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »