ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.56142356
2	ATP synthesis coupled proton transport (GO:0015986)	6.34221158
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.34221158
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.78851392
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.70711482
6	cytidine deamination (GO:0009972)	5.32368780
7	cytidine metabolic process (GO:0046087)	5.32368780
8	cytidine catabolic process (GO:0006216)	5.32368780
9	negative regulation of mast cell activation (GO:0033004)	4.82987447
10	behavioral response to nicotine (GO:0035095)	4.70882396
11	protein neddylation (GO:0045116)	4.41413808
12	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.38578490
13	respiratory electron transport chain (GO:0022904)	4.37812480
14	electron transport chain (GO:0022900)	4.35008836
15	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.33095920
16	negative regulation of calcium ion transport into cytosol (GO:0010523)	4.16355037
17	ATP biosynthetic process (GO:0006754)	4.09955140
18	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.09359304
19	protein complex biogenesis (GO:0070271)	3.76850780
20	ovulation cycle (GO:0042698)	3.68364750
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.63011959
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.63011959
23	NADH dehydrogenase complex assembly (GO:0010257)	3.63011959
24	hydrogen ion transmembrane transport (GO:1902600)	3.53651453
25	tyrosine phosphorylation of STAT protein (GO:0007260)	3.53562233
26	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.44367071
27	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.39223430
28	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.38214036
29	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.37691126
30	sequestering of actin monomers (GO:0042989)	3.35902018
31	mitochondrial respiratory chain complex assembly (GO:0033108)	3.33594978
32	ribosomal small subunit assembly (GO:0000028)	3.33378709
33	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.31006761
34	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.31006761
35	proton transport (GO:0015992)	3.28650821
36	protein-cofactor linkage (GO:0018065)	3.26230219
37	negative regulation of heart rate (GO:0010459)	3.25882185
38	response to pheromone (GO:0019236)	3.25649317
39	chaperone-mediated protein transport (GO:0072321)	3.23909894
40	kynurenine metabolic process (GO:0070189)	3.22400859
41	hydrogen transport (GO:0006818)	3.22099992
42	regulation of autophagic vacuole assembly (GO:2000785)	3.13787795
43	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.10759838
44	regulation of action potential (GO:0098900)	3.10739456
45	platelet dense granule organization (GO:0060155)	3.10247617
46	base-excision repair, AP site formation (GO:0006285)	3.06956890
47	protein localization to cilium (GO:0061512)	3.06887664
48	positive regulation of interleukin-17 production (GO:0032740)	3.04993430
49	indole-containing compound catabolic process (GO:0042436)	3.00215596
50	indolalkylamine catabolic process (GO:0046218)	3.00215596
51	tryptophan catabolic process (GO:0006569)	3.00215596
52	indolalkylamine metabolic process (GO:0006586)	2.95101606
53	positive regulation of defense response to virus by host (GO:0002230)	2.91846519
54	axonemal dynein complex assembly (GO:0070286)	2.89236851
55	regulation of female gonad development (GO:2000194)	2.88378745
56	axoneme assembly (GO:0035082)	2.87736194
57	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.86504399
58	amine catabolic process (GO:0009310)	2.86130473
59	cellular biogenic amine catabolic process (GO:0042402)	2.86130473
60	maturation of SSU-rRNA (GO:0030490)	2.82824261
61	water-soluble vitamin biosynthetic process (GO:0042364)	2.81824114
62	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.81705531
63	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.80796541
64	fucose catabolic process (GO:0019317)	2.79000330
65	L-fucose metabolic process (GO:0042354)	2.79000330
66	L-fucose catabolic process (GO:0042355)	2.79000330
67	mast cell degranulation (GO:0043303)	2.75027985
68	mast cell activation involved in immune response (GO:0002279)	2.75027985
69	positive regulation of cell fate commitment (GO:0010455)	2.74877205
70	positive regulation of protein homodimerization activity (GO:0090073)	2.73401570
71	regulation of activation of Janus kinase activity (GO:0010533)	2.69771187
72	protein peptidyl-prolyl isomerization (GO:0000413)	2.69622645
73	cellular ketone body metabolic process (GO:0046950)	2.67340516
74	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.66527966
75	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.64536435
76	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.64399703
77	mast cell activation (GO:0045576)	2.63880075
78	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.63609151
79	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.62632417
80	endoderm formation (GO:0001706)	2.62625310
81	regulation of vacuole organization (GO:0044088)	2.62069993
82	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.61919318
83	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.60506601
84	piRNA metabolic process (GO:0034587)	2.59997450
85	epithelial cilium movement (GO:0003351)	2.58601244
86	purine deoxyribonucleotide metabolic process (GO:0009151)	2.57071817
87	GPI anchor metabolic process (GO:0006505)	2.56907603
88	tryptophan metabolic process (GO:0006568)	2.52900717
89	regulation of memory T cell differentiation (GO:0043380)	2.52468382
90	preassembly of GPI anchor in ER membrane (GO:0016254)	2.49485467
91	ketone body metabolic process (GO:1902224)	2.48756133
92	molting cycle (GO:0042303)	2.48518912
93	hair cycle (GO:0042633)	2.48518912
94	purine deoxyribonucleotide catabolic process (GO:0009155)	2.47638965
95	deoxyribose phosphate catabolic process (GO:0046386)	2.45640349
96	regulation of transmission of nerve impulse (GO:0051969)	2.44620570
97	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.42512735
98	deoxyribonucleotide catabolic process (GO:0009264)	2.42374434
99	regulation of hypersensitivity (GO:0002883)	2.40739710
100	nucleoside triphosphate biosynthetic process (GO:0009142)	2.39877222

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.71609949
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.65616156
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.47417095
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.99511328
5	VDR_22108803_ChIP-Seq_LS180_Human	2.97721705
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.79662271
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.56652064
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.26667828
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.23244023
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.11216235
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.03061019
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.98900742
13	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.85530773
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.85003920
15	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.84477518
16	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.83938527
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.82184107
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.81557680
19	TP53_22573176_ChIP-Seq_HFKS_Human	1.80127187
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.79517776
21	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.75821229
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.69729007
23	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.69566684
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.63457198
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.60102707
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.60043642
27	SOX2_19829295_ChIP-Seq_ESCs_Human	1.54460488
28	NANOG_19829295_ChIP-Seq_ESCs_Human	1.54460488
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.47789361
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.45901698
31	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.45452009
32	TAF2_19829295_ChIP-Seq_ESCs_Human	1.45419821
33	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.44601627
34	AR_21572438_ChIP-Seq_LNCaP_Human	1.39383475
35	EWS_26573619_Chip-Seq_HEK293_Human	1.37671263
36	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.37020482
37	VDR_23849224_ChIP-Seq_CD4+_Human	1.36006670
38	FUS_26573619_Chip-Seq_HEK293_Human	1.35772841
39	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.35556078
40	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.35190814
41	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.34603956
42	MYC_19829295_ChIP-Seq_ESCs_Human	1.33993859
43	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.33387111
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.31137466
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.31137466
46	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.30322214
47	P300_19829295_ChIP-Seq_ESCs_Human	1.29623839
48	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.29255677
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.29003786
50	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.27796671
51	NANOG_20526341_ChIP-Seq_ESCs_Human	1.27305594
52	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.25704194
53	GATA3_26560356_Chip-Seq_TH2_Human	1.25402135
54	IGF1R_20145208_ChIP-Seq_DFB_Human	1.24740701
55	TAF15_26573619_Chip-Seq_HEK293_Human	1.24595946
56	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.24343075
57	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.24222552
58	REST_21632747_ChIP-Seq_MESCs_Mouse	1.24196046
59	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.23856908
60	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.22231548
61	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.20737342
62	NCOR_22424771_ChIP-Seq_293T_Human	1.19794946
63	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.19576201
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.19317253
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18851129
66	HOXB7_26014856_ChIP-Seq_BT474_Human	1.18166932
67	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.17155516
68	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.15911819
69	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.12942110
70	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.12592287
71	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11959989
72	BCAT_22108803_ChIP-Seq_LS180_Human	1.11857281
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.11572879
74	RNF2_27304074_Chip-Seq_NSC_Mouse	1.11078994
75	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10773705
76	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.10721039
77	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.10318086
78	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10146691
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10066174
80	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.08922247
81	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.06594399
82	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.05442517
83	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.04572570
84	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.04373227
85	ERA_21632823_ChIP-Seq_H3396_Human	1.03316674
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02379277
87	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.00251233
88	CBP_20019798_ChIP-Seq_JUKART_Human	1.00143757
89	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.00143757
90	P53_21459846_ChIP-Seq_SAOS-2_Human	0.98474851
91	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.98168557
92	AR_20517297_ChIP-Seq_VCAP_Human	0.97978286
93	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.95240891
94	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.95070001
95	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.93652401
96	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.93241661
97	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.92819294
98	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.91401834
99	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.90676329
100	MYC_18940864_ChIP-ChIP_HL60_Human	0.90496094

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005646_abnormal_pituitary_gland	3.28693326
2	MP0003195_calcinosis	2.99028403
3	MP0003646_muscle_fatigue	2.83482099
4	MP0009379_abnormal_foot_pigmentation	2.81770810
5	MP0005360_urolithiasis	2.80080358
6	MP0008875_abnormal_xenobiotic_pharmacok	2.53838154
7	MP0004885_abnormal_endolymph	2.53290337
8	MP0005671_abnormal_response_to	2.53253086
9	MP0008872_abnormal_physiological_respon	2.40219734
10	MP0006292_abnormal_olfactory_placode	2.36167154
11	MP0002837_dystrophic_cardiac_calcinosis	2.29418627
12	MP0002876_abnormal_thyroid_physiology	2.28378218
13	MP0002102_abnormal_ear_morphology	2.10449448
14	MP0002163_abnormal_gland_morphology	1.88694475
15	MP0004142_abnormal_muscle_tone	1.85343174
16	MP0008877_abnormal_DNA_methylation	1.81351640
17	MP0005645_abnormal_hypothalamus_physiol	1.80180852
18	MP0001835_abnormal_antigen_presentation	1.77915873
19	MP0005187_abnormal_penis_morphology	1.73472933
20	MP0001986_abnormal_taste_sensitivity	1.70911248
21	MP0005377_hearing/vestibular/ear_phenot	1.69653024
22	MP0003878_abnormal_ear_physiology	1.69653024
23	MP0006276_abnormal_autonomic_nervous	1.66326212
24	MP0001501_abnormal_sleep_pattern	1.61958008
25	MP0005551_abnormal_eye_electrophysiolog	1.61185338
26	MP0009785_altered_susceptibility_to	1.60802467
27	MP0002272_abnormal_nervous_system	1.59849884
28	MP0009333_abnormal_splenocyte_physiolog	1.59307464
29	MP0001919_abnormal_reproductive_system	1.56487185
30	MP0003122_maternal_imprinting	1.52807100
31	MP0009764_decreased_sensitivity_to	1.50626199
32	MP0005084_abnormal_gallbladder_morpholo	1.49348463
33	MP0009046_muscle_twitch	1.49154857
34	MP0004145_abnormal_muscle_electrophysio	1.47520226
35	MP0008775_abnormal_heart_ventricle	1.43371102
36	MP0002736_abnormal_nociception_after	1.42680652
37	MP0002254_reproductive_system_inflammat	1.41536309
38	MP0009745_abnormal_behavioral_response	1.39918351
39	MP0001968_abnormal_touch/_nociception	1.39359480
40	MP0001905_abnormal_dopamine_level	1.38744009
41	MP0003315_abnormal_perineum_morphology	1.38254188
42	MP0001348_abnormal_lacrimal_gland	1.34479807
43	MP0001485_abnormal_pinna_reflex	1.33995620
44	MP0003724_increased_susceptibility_to	1.31411292
45	MP0005389_reproductive_system_phenotype	1.26536505
46	MP0000372_irregular_coat_pigmentation	1.24369530
47	MP0001970_abnormal_pain_threshold	1.20653076
48	MP0002733_abnormal_thermal_nociception	1.19271925
49	MP0006072_abnormal_retinal_apoptosis	1.19155615
50	MP0005075_abnormal_melanosome_morpholog	1.16357640
51	MP0004043_abnormal_pH_regulation	1.16073230
52	MP0005167_abnormal_blood-brain_barrier	1.14518482
53	MP0001984_abnormal_olfaction	1.13934907
54	MP0005000_abnormal_immune_tolerance	1.11268464
55	MP0002938_white_spotting	1.09551766
56	MP0001440_abnormal_grooming_behavior	1.09116633
57	MP0001800_abnormal_humoral_immune	1.08673131
58	MP0005423_abnormal_somatic_nervous	1.06628173
59	MP0002572_abnormal_emotion/affect_behav	1.06353078
60	MP0003866_abnormal_defecation	1.05873614
61	MP0001765_abnormal_ion_homeostasis	1.04756626
62	MP0004147_increased_porphyrin_level	1.03198069
63	MP0001873_stomach_inflammation	1.02157659
64	MP0003121_genomic_imprinting	1.00931735
65	MP0000516_abnormal_urinary_system	1.00702047
66	MP0005367_renal/urinary_system_phenotyp	1.00702047
67	MP0002234_abnormal_pharynx_morphology	0.99499415
68	MP0006082_CNS_inflammation	0.96948685
69	MP0000685_abnormal_immune_system	0.95362825
70	MP0005379_endocrine/exocrine_gland_phen	0.94835580
71	MP0004742_abnormal_vestibular_system	0.94698159
72	MP0004133_heterotaxia	0.94565353
73	MP0002557_abnormal_social/conspecific_i	0.93321990
74	MP0002148_abnormal_hypersensitivity_rea	0.91653253
75	MP0003638_abnormal_response/metabolism_	0.89912000
76	MP0003879_abnormal_hair_cell	0.89222408
77	MP0003880_abnormal_central_pattern	0.89105582
78	MP0005332_abnormal_amino_acid	0.88837627
79	MP0008995_early_reproductive_senescence	0.88131641
80	MP0000230_abnormal_systemic_arterial	0.87351940
81	MP0002160_abnormal_reproductive_system	0.86007229
82	MP0006036_abnormal_mitochondrial_physio	0.85142992
83	MP0001486_abnormal_startle_reflex	0.85064664
84	MP0002638_abnormal_pupillary_reflex	0.83114457
85	MP0010329_abnormal_lipoprotein_level	0.80188167
86	MP0002063_abnormal_learning/memory/cond	0.78929783
87	MP0003787_abnormal_imprinting	0.77327092
88	MP0000026_abnormal_inner_ear	0.77051553
89	MP0002420_abnormal_adaptive_immunity	0.76215565
90	MP0002723_abnormal_immune_serum	0.76136764
91	MP0002184_abnormal_innervation	0.75687779
92	MP0003635_abnormal_synaptic_transmissio	0.75297837
93	MP0003283_abnormal_digestive_organ	0.74647053
94	MP0001963_abnormal_hearing_physiology	0.74625697
95	MP0005253_abnormal_eye_physiology	0.73737009
96	MP0002064_seizures	0.73642576
97	MP0001819_abnormal_immune_cell	0.72806132
98	MP0003436_decreased_susceptibility_to	0.72588241
99	MP0003186_abnormal_redox_activity	0.71363882
100	MP0003123_paternal_imprinting	0.71280905

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	3.67611209
2	Mitochondrial inheritance (HP:0001427)	3.62994537
3	Acute necrotizing encephalopathy (HP:0006965)	3.58405272
4	Elevated erythrocyte sedimentation rate (HP:0003565)	3.44269689
5	Increased CSF lactate (HP:0002490)	3.41884128
6	Renal cortical cysts (HP:0000803)	3.32823272
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.29665436
8	3-Methylglutaconic aciduria (HP:0003535)	3.28349540
9	Retrobulbar optic neuritis (HP:0100654)	3.24407133
10	Optic neuritis (HP:0100653)	3.24407133
11	Acute encephalopathy (HP:0006846)	3.23240298
12	Hepatocellular necrosis (HP:0001404)	3.21559264
13	Progressive macrocephaly (HP:0004481)	3.15855159
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.15124460
15	Hepatic necrosis (HP:0002605)	3.13045296
16	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.10625709
17	Absent/shortened dynein arms (HP:0200106)	3.10625709
18	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.02069513
19	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.02069513
20	Abnormality of the renal cortex (HP:0011035)	2.96575765
21	Increased hepatocellular lipid droplets (HP:0006565)	2.94380695
22	Nephronophthisis (HP:0000090)	2.94053617
23	Lipid accumulation in hepatocytes (HP:0006561)	2.83689504
24	Orchitis (HP:0100796)	2.82564335
25	Stomach cancer (HP:0012126)	2.81113182
26	Congenital, generalized hypertrichosis (HP:0004540)	2.76118281
27	Abnormality of B cell number (HP:0010975)	2.73070928
28	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.72667954
29	True hermaphroditism (HP:0010459)	2.71788102
30	Pancreatic cysts (HP:0001737)	2.69749729
31	Abnormality of midbrain morphology (HP:0002418)	2.69297691
32	Molar tooth sign on MRI (HP:0002419)	2.69297691
33	Decreased central vision (HP:0007663)	2.67784515
34	Keratoconjunctivitis (HP:0001096)	2.65615026
35	Increased IgM level (HP:0003496)	2.59811124
36	Myositis (HP:0100614)	2.58688517
37	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.58534302
38	Abnormal respiratory motile cilium morphology (HP:0005938)	2.57974626
39	Abnormal respiratory epithelium morphology (HP:0012253)	2.57974626
40	Abnormal rod and cone electroretinograms (HP:0008323)	2.55148065
41	Renal Fanconi syndrome (HP:0001994)	2.51259770
42	IgG deficiency (HP:0004315)	2.49705379
43	Increased corneal curvature (HP:0100692)	2.48893319
44	Keratoconus (HP:0000563)	2.48893319
45	Abnormality of the renal medulla (HP:0100957)	2.44869940
46	Optic disc pallor (HP:0000543)	2.44456083
47	Increased intramyocellular lipid droplets (HP:0012240)	2.40601041
48	Generalized aminoaciduria (HP:0002909)	2.39413516
49	Agitation (HP:0000713)	2.38176272
50	Pancreatic fibrosis (HP:0100732)	2.31161797
51	Attenuation of retinal blood vessels (HP:0007843)	2.28526604
52	Abnormal ciliary motility (HP:0012262)	2.27786434
53	Hypothermia (HP:0002045)	2.25903676
54	Cerebral edema (HP:0002181)	2.17907180
55	Abnormality of the labia minora (HP:0012880)	2.16351546
56	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.15477886
57	Abnormal respiratory motile cilium physiology (HP:0012261)	2.15342195
58	Hypomagnesemia (HP:0002917)	2.13113859
59	Lactic acidosis (HP:0003128)	2.12977490
60	Large eyes (HP:0001090)	2.11963715
61	Increased serum lactate (HP:0002151)	2.11429482
62	Tongue fasciculations (HP:0001308)	2.10730020
63	Medial flaring of the eyebrow (HP:0010747)	2.10050117
64	Methylmalonic acidemia (HP:0002912)	2.07884872
65	Exertional dyspnea (HP:0002875)	2.06768539
66	Sclerocornea (HP:0000647)	2.04652355
67	Increased muscle lipid content (HP:0009058)	2.04562356
68	Abnormality of magnesium homeostasis (HP:0004921)	2.03036663
69	Abnormality of cells of the erythroid lineage (HP:0012130)	2.01862886
70	Methylmalonic aciduria (HP:0012120)	2.00121755
71	Hypoproteinemia (HP:0003075)	1.97203102
72	Respiratory failure (HP:0002878)	1.96548754
73	Keratoconjunctivitis sicca (HP:0001097)	1.94866693
74	Abnormal number of erythroid precursors (HP:0012131)	1.93481331
75	Pendular nystagmus (HP:0012043)	1.92028773
76	Abnormal drinking behavior (HP:0030082)	1.91828166
77	Polydipsia (HP:0001959)	1.91828166
78	Pachygyria (HP:0001302)	1.89770097
79	Hypoplasia of the uterus (HP:0000013)	1.89035287
80	Congenital hepatic fibrosis (HP:0002612)	1.87500746
81	Abnormality of T cell number (HP:0011839)	1.86798206
82	Abolished electroretinogram (ERG) (HP:0000550)	1.86132769
83	Adactyly (HP:0009776)	1.86007510
84	Broad-based gait (HP:0002136)	1.84685403
85	Abnormality of urine glucose concentration (HP:0011016)	1.84021284
86	Glycosuria (HP:0003076)	1.84021284
87	Congenital sensorineural hearing impairment (HP:0008527)	1.83003420
88	Limb dystonia (HP:0002451)	1.81554698
89	Asplenia (HP:0001746)	1.81034381
90	Abnormality of renal resorption (HP:0011038)	1.80544360
91	Stomatitis (HP:0010280)	1.79351906
92	Tetany (HP:0001281)	1.79347551
93	Abnormality of eosinophils (HP:0001879)	1.78255013
94	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.77704018
95	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.77685259
96	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.77571803
97	Chronic bronchitis (HP:0004469)	1.76955822
98	Short tibia (HP:0005736)	1.73274594
99	Type II lissencephaly (HP:0007260)	1.73239811
100	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.71377106

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	4.11319982
2	TIE1	3.69994595
3	TAOK3	3.17990373
4	FRK	3.13423667
5	GRK1	3.01780380
6	ADRBK2	2.75395293
7	KDR	2.69656433
8	PINK1	2.63458481
9	WNK4	2.53988512
10	BCKDK	2.52014107
11	NUAK1	2.14231384
12	ZAK	1.97657891
13	BMPR1B	1.91174517
14	MAP3K12	1.86698582
15	BMPR2	1.86625173
16	WNK3	1.65072872
17	MAP4K2	1.64219903
18	LIMK1	1.57599168
19	CAMKK2	1.54963620
20	MYLK	1.54610075
21	ERBB3	1.52607694
22	TXK	1.50106201
23	EPHA3	1.49812470
24	MAP2K7	1.43037294
25	GRK6	1.34366456
26	MAP2K6	1.25039667
27	TESK2	1.20984486
28	IKBKB	1.11197964
29	INSRR	1.08210626
30	DAPK2	1.04185316
31	MAP3K4	1.02100590
32	DYRK2	1.01133155
33	CDK19	1.00791444
34	MUSK	0.97445820
35	TEC	0.96513695
36	CSNK1G2	0.95978798
37	PTK2B	0.92139280
38	NEK1	0.91146111
39	CAMKK1	0.87581562
40	BUB1	0.85439316
41	NTRK2	0.85125989
42	VRK1	0.83480404
43	ADRBK1	0.82772536
44	TESK1	0.80573917
45	SCYL2	0.80000239
46	TRPM7	0.77885635
47	MAPK13	0.76305067
48	OXSR1	0.75031752
49	CSNK1G3	0.74224823
50	OBSCN	0.73167555
51	FES	0.72790972
52	PRKCQ	0.72066315
53	FLT3	0.69922828
54	MARK1	0.69027743
55	PIK3CA	0.68985425
56	ITK	0.67498107
57	PRKCG	0.65970631
58	SYK	0.63987716
59	LYN	0.63548751
60	SIK2	0.63176439
61	BLK	0.63013193
62	KIT	0.62354282
63	PRKCH	0.60613593
64	TRIM28	0.60573123
65	MAP4K1	0.59982974
66	PHKG2	0.58006835
67	PHKG1	0.58006835
68	WNK1	0.57623043
69	ABL2	0.56693312
70	CHUK	0.54031843
71	VRK2	0.53820961
72	ILK	0.53021358
73	PRKACA	0.51063212
74	TAF1	0.49888836
75	PLK2	0.49664066
76	CSNK1A1L	0.49494064
77	BTK	0.49314687
78	RPS6KA5	0.48640247
79	NEK2	0.46718369
80	IKBKE	0.45670483
81	CAMK2A	0.45357401
82	LCK	0.44720275
83	PRKCE	0.44703360
84	PLK4	0.44515624
85	TGFBR1	0.44359385
86	PTK6	0.44050144
87	PAK3	0.43751673
88	ROCK1	0.43333905
89	MARK3	0.43282718
90	GRK5	0.43207984
91	PASK	0.42144970
92	MAP3K11	0.41582499
93	PRKCA	0.41125679
94	BRSK2	0.40597950
95	CSNK1G1	0.39659990
96	MAP3K14	0.37038634
97	GRK7	0.36347132
98	PLK3	0.36116605
99	STK39	0.36055219
100	MKNK2	0.34640247

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.22257795
2	Parkinsons disease_Homo sapiens_hsa05012	3.47695099
3	Asthma_Homo sapiens_hsa05310	3.34227106
4	Ribosome_Homo sapiens_hsa03010	2.71686493
5	Graft-versus-host disease_Homo sapiens_hsa05332	2.66277195
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.60019307
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.55333416
8	Allograft rejection_Homo sapiens_hsa05330	2.52599606
9	Alzheimers disease_Homo sapiens_hsa05010	2.50184854
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.40566922
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.34554222
12	Proteasome_Homo sapiens_hsa03050	2.33962498
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.29113069
14	Huntingtons disease_Homo sapiens_hsa05016	2.14365212
15	Primary immunodeficiency_Homo sapiens_hsa05340	2.02157441
16	Phototransduction_Homo sapiens_hsa04744	1.98226857
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.97839011
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.83226734
19	Protein export_Homo sapiens_hsa03060	1.82944234
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.79902162
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.78771829
22	RNA polymerase_Homo sapiens_hsa03020	1.78015287
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.60271646
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.47822271
25	Nicotine addiction_Homo sapiens_hsa05033	1.38133512
26	Antigen processing and presentation_Homo sapiens_hsa04612	1.34874869
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.32637901
28	Caffeine metabolism_Homo sapiens_hsa00232	1.30959196
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.28333150
30	Propanoate metabolism_Homo sapiens_hsa00640	1.20756466
31	Rheumatoid arthritis_Homo sapiens_hsa05323	1.20707109
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.19542504
33	One carbon pool by folate_Homo sapiens_hsa00670	1.12382715
34	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.04721849
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.03940805
36	Peroxisome_Homo sapiens_hsa04146	1.03523146
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.01799479
38	Olfactory transduction_Homo sapiens_hsa04740	0.99057531
39	Tryptophan metabolism_Homo sapiens_hsa00380	0.95218537
40	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.93576156
41	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.93276846
42	RNA degradation_Homo sapiens_hsa03018	0.92515762
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.92076628
44	Viral myocarditis_Homo sapiens_hsa05416	0.91570748
45	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.90629539
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.88691547
47	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.82667037
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.81780079
49	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.80839520
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.78538849
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.76101726
52	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.75589058
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.74119662
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72798788
55	Morphine addiction_Homo sapiens_hsa05032	0.67810401
56	Taste transduction_Homo sapiens_hsa04742	0.67653451
57	Butanoate metabolism_Homo sapiens_hsa00650	0.66423833
58	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.64821031
59	Homologous recombination_Homo sapiens_hsa03440	0.64288849
60	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.63644380
61	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.61915785
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.61582320
63	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.60209869
64	Salivary secretion_Homo sapiens_hsa04970	0.57703680
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56995456
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.56629484
67	Purine metabolism_Homo sapiens_hsa00230	0.56607715
68	Pyrimidine metabolism_Homo sapiens_hsa00240	0.56595852
69	Retinol metabolism_Homo sapiens_hsa00830	0.54564176
70	Serotonergic synapse_Homo sapiens_hsa04726	0.54480056
71	Metabolic pathways_Homo sapiens_hsa01100	0.54352640
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54186538
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.54077599
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50384570
75	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.48719863
76	Mineral absorption_Homo sapiens_hsa04978	0.48189813
77	Circadian entrainment_Homo sapiens_hsa04713	0.47827909
78	GABAergic synapse_Homo sapiens_hsa04727	0.47278876
79	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.46828659
80	Glutamatergic synapse_Homo sapiens_hsa04724	0.46570503
81	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.43805223
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43230409
83	Insulin secretion_Homo sapiens_hsa04911	0.41176244
84	Leishmaniasis_Homo sapiens_hsa05140	0.40683718
85	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.37598221
86	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37555367
87	Regulation of autophagy_Homo sapiens_hsa04140	0.36194533
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33470762
89	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.33132512
90	Tyrosine metabolism_Homo sapiens_hsa00350	0.31370945
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.28522921
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.26029133
93	Calcium signaling pathway_Homo sapiens_hsa04020	0.25337761
94	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.23051202
95	Amphetamine addiction_Homo sapiens_hsa05031	0.22120064
96	ABC transporters_Homo sapiens_hsa02010	0.22002081
97	Pancreatic secretion_Homo sapiens_hsa04972	0.18570322
98	Cocaine addiction_Homo sapiens_hsa05030	0.18504521
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.17051882
100	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.16565787

ATP5LP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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