ATP5LP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)8.66584113
2cytidine deamination (GO:0009972)8.66584113
3cytidine metabolic process (GO:0046087)8.66584113
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.33431853
5pyrimidine ribonucleoside catabolic process (GO:0046133)7.62687472
6DNA deamination (GO:0045006)7.56257034
7Arp2/3 complex-mediated actin nucleation (GO:0034314)5.47534113
8regulation of autophagic vacuole assembly (GO:2000785)5.33828773
9sequestering of actin monomers (GO:0042989)5.09860420
10positive T cell selection (GO:0043368)5.02243307
11positive thymic T cell selection (GO:0045059)5.02052899
12actin nucleation (GO:0045010)4.99898786
13protein localization to cilium (GO:0061512)4.77439695
14keratinocyte development (GO:0003334)4.63421577
15negative regulation by host of viral transcription (GO:0043922)4.58587642
16T cell migration (GO:0072678)4.58355028
17negative T cell selection (GO:0043383)4.50671389
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.37804475
19cytolysis (GO:0019835)4.33174165
20regulation of vacuole organization (GO:0044088)4.26490635
21positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.21729786
22positive regulation of natural killer cell mediated immunity (GO:0002717)4.19968438
23regulation of activation of Janus kinase activity (GO:0010533)4.15904905
24positive regulation of calcium-mediated signaling (GO:0050850)4.08845787
25negative regulation of T cell apoptotic process (GO:0070233)4.07622925
26pyrimidine nucleoside catabolic process (GO:0046135)3.96750682
27ATP synthesis coupled proton transport (GO:0015986)3.93877992
28energy coupled proton transport, down electrochemical gradient (GO:0015985)3.93877992
29eosinophil chemotaxis (GO:0048245)3.88388830
30positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.80026608
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.71470185
32thymic T cell selection (GO:0045061)3.68739527
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.68493795
34negative regulation of viral genome replication (GO:0045071)3.66765145
35cellular response to interleukin-15 (GO:0071350)3.62955163
36negative thymic T cell selection (GO:0045060)3.56829112
37regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.55684745
38regulation of natural killer cell mediated immunity (GO:0002715)3.55684745
39eosinophil migration (GO:0072677)3.53148048
40ribosomal small subunit assembly (GO:0000028)3.50223283
41positive regulation of T cell apoptotic process (GO:0070234)3.48689738
42regulation of B cell receptor signaling pathway (GO:0050855)3.44837622
43iron-sulfur cluster assembly (GO:0016226)3.42595207
44metallo-sulfur cluster assembly (GO:0031163)3.42595207
45positive regulation of tolerance induction (GO:0002645)3.40324011
46positive regulation of cell adhesion mediated by integrin (GO:0033630)3.39478921
47positive regulation of interleukin-8 secretion (GO:2000484)3.39229802
48negative regulation of stress fiber assembly (GO:0051497)3.36601952
49positive regulation of cell killing (GO:0031343)3.36304592
50regulation of leukocyte mediated cytotoxicity (GO:0001910)3.33984329
51regulation of chronic inflammatory response (GO:0002676)3.33128811
52T cell receptor signaling pathway (GO:0050852)3.32663220
53macrophage chemotaxis (GO:0048246)3.28666882
54regulation of protein polyubiquitination (GO:1902914)3.27427945
55positive regulation of T cell mediated cytotoxicity (GO:0001916)3.24521978
56regulation of T cell tolerance induction (GO:0002664)3.24263286
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.20115156
58T cell selection (GO:0045058)3.17022638
59regulation of lymphocyte chemotaxis (GO:1901623)3.16917663
60activated T cell proliferation (GO:0050798)3.15543141
61respiratory electron transport chain (GO:0022904)3.10741197
62behavioral response to nicotine (GO:0035095)3.10183195
63DNA demethylation (GO:0080111)3.09479071
64negative regulation of macroautophagy (GO:0016242)3.08217684
65regulation of T cell chemotaxis (GO:0010819)3.07885239
66positive regulation of T cell chemotaxis (GO:0010820)3.07885239
67electron transport chain (GO:0022900)3.06217395
68negative regulation of oxidoreductase activity (GO:0051354)3.04403363
69regulation of T cell apoptotic process (GO:0070232)3.01202148
70positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.99613841
71regulation of cell killing (GO:0031341)2.98732714
72regulation of calcium-mediated signaling (GO:0050848)2.98567781
73negative regulation of actin filament bundle assembly (GO:0032232)2.94970499
74pyrimidine-containing compound catabolic process (GO:0072529)2.93004309
75regulation of ruffle assembly (GO:1900027)2.90390121
76centrosome localization (GO:0051642)2.88551849
77T cell costimulation (GO:0031295)2.88070215
78regulation of T cell receptor signaling pathway (GO:0050856)2.87953290
79lymphocyte costimulation (GO:0031294)2.87102266
80protein neddylation (GO:0045116)2.86062552
81regulation of interleukin-8 secretion (GO:2000482)2.85819348
82regulation of T cell mediated cytotoxicity (GO:0001914)2.85055073
83negative regulation of nitric-oxide synthase activity (GO:0051001)2.81896128
84positive regulation of lymphocyte migration (GO:2000403)2.77247023
85positive regulation of monocyte chemotaxis (GO:0090026)2.74269742
86DNA dealkylation (GO:0035510)2.73706106
87antigen receptor-mediated signaling pathway (GO:0050851)2.72326947
88negative regulation of lymphocyte apoptotic process (GO:0070229)2.70347175
89positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.69236038
90positive regulation of alpha-beta T cell proliferation (GO:0046641)2.68764422
91lymphocyte migration (GO:0072676)2.68630999
92antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.65330685
93regulation of viral genome replication (GO:0045069)2.64933258
94regulation of regulatory T cell differentiation (GO:0045589)2.64000376
95regulation of tolerance induction (GO:0002643)2.63224699
96regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.62958487
97positive regulation of lymphocyte apoptotic process (GO:0070230)2.61820954
98positive regulation of uterine smooth muscle contraction (GO:0070474)2.61805329
99autophagic vacuole fusion (GO:0000046)2.59140432
100negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.57082813

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.37013029
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.92767073
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.74147554
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.89928895
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.88654360
6EZH2_22144423_ChIP-Seq_EOC_Human3.87205727
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.51734838
8VDR_22108803_ChIP-Seq_LS180_Human3.47044453
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.46993594
10IRF8_22096565_ChIP-ChIP_GC-B_Human3.44577102
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.47456125
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.17690811
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17646759
14MYB_26560356_Chip-Seq_TH2_Human2.01274437
15IRF8_21731497_ChIP-ChIP_J774_Mouse1.94192722
16ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89080903
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85644647
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72948270
19RUNX_20019798_ChIP-Seq_JUKART_Human1.67765295
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66145671
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.65858169
22IGF1R_20145208_ChIP-Seq_DFB_Human1.62474339
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.60078468
24GATA3_27048872_Chip-Seq_THYMUS_Human1.58906587
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58146831
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55364800
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51849140
28MYB_26560356_Chip-Seq_TH1_Human1.51816704
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.51738609
30VDR_23849224_ChIP-Seq_CD4+_Human1.50371551
31ZNF274_21170338_ChIP-Seq_K562_Hela1.49546119
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.41061068
33HTT_18923047_ChIP-ChIP_STHdh_Human1.39886953
34RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.39072096
35GATA3_26560356_Chip-Seq_TH2_Human1.38637615
36UTX_26944678_Chip-Seq_JUKART_Human1.37945902
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32216336
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32114391
39EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.30316152
40CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29150686
41FOXP3_21729870_ChIP-Seq_TREG_Human1.27295635
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.26699721
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26313599
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25377380
45PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.25296714
46BCAT_22108803_ChIP-Seq_LS180_Human1.23738240
47NANOG_20526341_ChIP-Seq_ESCs_Human1.23469836
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20473692
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18745046
50TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18587179
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18324389
52TAF2_19829295_ChIP-Seq_ESCs_Human1.17622429
53MAF_26560356_Chip-Seq_TH2_Human1.17313408
54NCOR_22424771_ChIP-Seq_293T_Human1.14736116
55PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.12867704
56ELK1_19687146_ChIP-ChIP_HELA_Human1.12164476
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.11043751
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.10634248
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08441982
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06841724
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06509257
62ER_23166858_ChIP-Seq_MCF-7_Human1.04940667
63RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04791329
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.02712571
65BCL6_27268052_Chip-Seq_Bcells_Human1.02567767
66NANOG_19829295_ChIP-Seq_ESCs_Human1.01764273
67SOX2_19829295_ChIP-Seq_ESCs_Human1.01764273
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.01010134
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00672142
70EZH2_27304074_Chip-Seq_ESCs_Mouse0.98937330
71TP53_22573176_ChIP-Seq_HFKS_Human0.97871383
72CTCF_20526341_ChIP-Seq_ESCs_Human0.97074231
73PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96389039
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95842881
75MYC_19829295_ChIP-Seq_ESCs_Human0.95337014
76STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95148483
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93548283
78GATA3_21878914_ChIP-Seq_MCF-7_Human0.90766369
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90622105
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88913950
81SRF_21415370_ChIP-Seq_HL-1_Mouse0.88506394
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87015256
83PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86840472
84SA1_27219007_Chip-Seq_Bcells_Human0.86834691
85CTCF_27219007_Chip-Seq_Bcells_Human0.85799674
86RNF2_27304074_Chip-Seq_NSC_Mouse0.85749486
87E2F1_20622854_ChIP-Seq_HELA_Human0.84209349
88SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.83799692
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83489540
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.83135869
91SUZ12_27294783_Chip-Seq_ESCs_Mouse0.82976192
92FLI1_27457419_Chip-Seq_LIVER_Mouse0.82838469
93BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82738750
94EZH2_27294783_Chip-Seq_ESCs_Mouse0.82685827
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82416827
96AR_20517297_ChIP-Seq_VCAP_Human0.82262468
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.82226185
98ERA_21632823_ChIP-Seq_H3396_Human0.81605591
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81569558
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81542259

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.76588070
2MP0009379_abnormal_foot_pigmentation3.83735988
3MP0003763_abnormal_thymus_physiology3.32131615
4MP0009785_altered_susceptibility_to3.13633568
5MP0002102_abnormal_ear_morphology3.04402248
6MP0009333_abnormal_splenocyte_physiolog2.58307020
7MP0001835_abnormal_antigen_presentation2.39019685
8MP0005000_abnormal_immune_tolerance2.29125292
9MP0001873_stomach_inflammation2.16083788
10MP0001800_abnormal_humoral_immune2.11284578
11MP0005025_abnormal_response_to2.07933214
12MP0002420_abnormal_adaptive_immunity2.03079638
13MP0002166_altered_tumor_susceptibility2.02618671
14MP0001819_abnormal_immune_cell1.95599448
15MP0002723_abnormal_immune_serum1.90968607
16MP0002148_abnormal_hypersensitivity_rea1.90188601
17MP0006082_CNS_inflammation1.90080406
18MP0003880_abnormal_central_pattern1.81177303
19MP0004142_abnormal_muscle_tone1.80394164
20MP0003646_muscle_fatigue1.78762093
21MP0005645_abnormal_hypothalamus_physiol1.77242527
22MP0002876_abnormal_thyroid_physiology1.75478377
23MP0003283_abnormal_digestive_organ1.75317435
24MP0005360_urolithiasis1.62879151
25MP0001790_abnormal_immune_system1.60141028
26MP0005387_immune_system_phenotype1.60141028
27MP0008872_abnormal_physiological_respon1.57203630
28MP0002006_tumorigenesis1.51804372
29MP0002452_abnormal_antigen_presenting1.51230898
30MP0006035_abnormal_mitochondrial_morpho1.49483565
31MP0000716_abnormal_immune_system1.47899471
32MP0002933_joint_inflammation1.47217516
33MP0002163_abnormal_gland_morphology1.45640912
34MP0001905_abnormal_dopamine_level1.45492673
35MP0000685_abnormal_immune_system1.44350095
36MP0005646_abnormal_pituitary_gland1.38197049
37MP0002398_abnormal_bone_marrow1.37979210
38MP0001968_abnormal_touch/_nociception1.35400499
39MP0006276_abnormal_autonomic_nervous1.34350680
40MP0000049_abnormal_middle_ear1.33808533
41MP0003866_abnormal_defecation1.33733807
42MP0003436_decreased_susceptibility_to1.32491173
43MP0000639_abnormal_adrenal_gland1.32446399
44MP0005377_hearing/vestibular/ear_phenot1.32351223
45MP0003878_abnormal_ear_physiology1.32351223
46MP0002837_dystrophic_cardiac_calcinosis1.31445249
47MP0005551_abnormal_eye_electrophysiolog1.31141058
48MP0000703_abnormal_thymus_morphology1.30794250
49MP0002405_respiratory_system_inflammati1.30409137
50MP0002249_abnormal_larynx_morphology1.29488029
51MP0001845_abnormal_inflammatory_respons1.21447716
52MP0001485_abnormal_pinna_reflex1.19262052
53MP0008875_abnormal_xenobiotic_pharmacok1.19043266
54MP0002419_abnormal_innate_immunity1.17745002
55MP0008995_early_reproductive_senescence1.17669342
56MP0008877_abnormal_DNA_methylation1.17633069
57MP0006292_abnormal_olfactory_placode1.17577550
58MP0002722_abnormal_immune_system1.17323663
59MP0002736_abnormal_nociception_after1.14064294
60MP0000689_abnormal_spleen_morphology1.13358225
61MP0010155_abnormal_intestine_physiology1.13153523
62MP0008961_abnormal_basal_metabolism1.11041967
63MP0001919_abnormal_reproductive_system1.10389650
64MP0003448_altered_tumor_morphology1.08517252
65MP0003137_abnormal_impulse_conducting1.07816865
66MP0004145_abnormal_muscle_electrophysio1.05108139
67MP0002277_abnormal_respiratory_mucosa1.04727404
68MP0006072_abnormal_retinal_apoptosis1.02966526
69MP0002429_abnormal_blood_cell0.99951677
70MP0009745_abnormal_behavioral_response0.95132710
71MP0005636_abnormal_mineral_homeostasis0.94354189
72MP0001188_hyperpigmentation0.91616924
73MP0004885_abnormal_endolymph0.90679205
74MP0005084_abnormal_gallbladder_morpholo0.89578085
75MP0008469_abnormal_protein_level0.87099399
76MP0005389_reproductive_system_phenotype0.85635608
77MP0002095_abnormal_skin_pigmentation0.85122336
78MP0005379_endocrine/exocrine_gland_phen0.84315231
79MP0002733_abnormal_thermal_nociception0.82335386
80MP0004147_increased_porphyrin_level0.79872383
81MP0008789_abnormal_olfactory_epithelium0.78365119
82MP0009764_decreased_sensitivity_to0.77812101
83MP0005174_abnormal_tail_pigmentation0.76859692
84MP0002272_abnormal_nervous_system0.75455320
85MP0001970_abnormal_pain_threshold0.75374519
86MP0000604_amyloidosis0.75143473
87MP0001765_abnormal_ion_homeostasis0.74546782
88MP0002693_abnormal_pancreas_physiology0.74509556
89MP0009643_abnormal_urine_homeostasis0.73656493
90MP0000026_abnormal_inner_ear0.73242383
91MP0005166_decreased_susceptibility_to0.73010928
92MP0003786_premature_aging0.72722709
93MP0004742_abnormal_vestibular_system0.72414702
94MP0002136_abnormal_kidney_physiology0.72330114
95MP0003045_fibrosis0.71694631
96MP0000372_irregular_coat_pigmentation0.70887733
97MP0009763_increased_sensitivity_to0.69126773
98MP0001986_abnormal_taste_sensitivity0.67718205
99MP0001963_abnormal_hearing_physiology0.66522924
100MP0002138_abnormal_hepatobiliary_system0.64156314

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.03248811
2T lymphocytopenia (HP:0005403)4.72184888
3Abnormality of T cell number (HP:0011839)4.71640633
4Increased IgM level (HP:0003496)4.40669963
5IgG deficiency (HP:0004315)4.29631181
6Severe combined immunodeficiency (HP:0004430)3.94252413
7Congenital stationary night blindness (HP:0007642)3.80795493
8Hypoproteinemia (HP:0003075)3.76204821
9Elevated erythrocyte sedimentation rate (HP:0003565)3.69571289
10Autoimmune hemolytic anemia (HP:0001890)3.62436750
11Mitochondrial inheritance (HP:0001427)3.43847855
12Radial bowing (HP:0002986)3.37187797
13Brushfield spots (HP:0001088)3.35211511
14Abnormality of T cells (HP:0002843)3.31307758
15Abnormality of B cell number (HP:0010975)3.29399549
16Acute necrotizing encephalopathy (HP:0006965)3.27486244
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.25068847
18Infantile muscular hypotonia (HP:0008947)3.18098521
19Abnormal mitochondria in muscle tissue (HP:0008316)3.02241402
20Combined immunodeficiency (HP:0005387)3.00149711
21Increased intramyocellular lipid droplets (HP:0012240)2.99888062
22Abnormal rod and cone electroretinograms (HP:0008323)2.88670837
23Thyroiditis (HP:0100646)2.84833723
24Abnormality of eosinophils (HP:0001879)2.83273392
25Short tibia (HP:0005736)2.79690766
26Abnormality of the prostate (HP:0008775)2.70012197
27Chronic diarrhea (HP:0002028)2.68019039
28Hepatocellular necrosis (HP:0001404)2.65248335
29Acute encephalopathy (HP:0006846)2.64655957
30Cerebral edema (HP:0002181)2.63929652
31Encephalitis (HP:0002383)2.62892833
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.61173661
33Increased muscle lipid content (HP:0009058)2.59286005
34Progressive macrocephaly (HP:0004481)2.58954139
35Increased CSF lactate (HP:0002490)2.56836619
36Severe visual impairment (HP:0001141)2.56546517
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.55852874
38Eosinophilia (HP:0001880)2.51934028
39Increased hepatocellular lipid droplets (HP:0006565)2.50774784
40Lissencephaly (HP:0001339)2.49414451
41Stomatitis (HP:0010280)2.48761899
42B lymphocytopenia (HP:0010976)2.46316693
43Lipid accumulation in hepatocytes (HP:0006561)2.41432051
44Attenuation of retinal blood vessels (HP:0007843)2.40068137
45Type II lissencephaly (HP:0007260)2.38450868
46Pancytopenia (HP:0001876)2.36593334
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.35131329
48Abnormal number of erythroid precursors (HP:0012131)2.34393313
49Hepatic necrosis (HP:0002605)2.33441840
503-Methylglutaconic aciduria (HP:0003535)2.33082133
51Autoimmune thrombocytopenia (HP:0001973)2.32386704
52Hypoplasia of the thymus (HP:0000778)2.30081264
53Renal Fanconi syndrome (HP:0001994)2.30024687
54Acute hepatic failure (HP:0006554)2.26507994
55Renal cortical cysts (HP:0000803)2.25850739
56Abnormal albumin level (HP:0012116)2.23402760
57Hypoalbuminemia (HP:0003073)2.23402760
58Optic disc pallor (HP:0000543)2.22288877
59Hypergammaglobulinemia (HP:0010702)2.19462337
60Chronic mucocutaneous candidiasis (HP:0002728)2.19036051
61Recurrent cutaneous fungal infections (HP:0011370)2.19036051
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18362737
63Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18362737
64Bowing of the arm (HP:0006488)2.18120913
65Bowed forearm bones (HP:0003956)2.18120913
66Hypoplasia of the pons (HP:0012110)2.15723006
67Focal motor seizures (HP:0011153)2.08879439
68Short 4th metacarpal (HP:0010044)2.07606870
69Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.07606870
70Abnormality of cells of the erythroid lineage (HP:0012130)2.06427323
71Hypoplasia of the ulna (HP:0003022)2.06290065
72Abnormality of the renal cortex (HP:0011035)2.04391177
73Abnormality of the pons (HP:0007361)2.04105906
74Abolished electroretinogram (ERG) (HP:0000550)2.03709720
75Leukocytosis (HP:0001974)2.02657636
76Gastrointestinal infarctions (HP:0005244)2.02104601
77Recurrent bronchitis (HP:0002837)1.99187919
78Pancreatic cysts (HP:0001737)1.96461842
79Female pseudohermaphroditism (HP:0010458)1.94964900
80Constricted visual fields (HP:0001133)1.94187718
81Decreased central vision (HP:0007663)1.93855665
82Cerebellar dysplasia (HP:0007033)1.93232422
83Lymphopenia (HP:0001888)1.93065141
84Abnormality of cells of the lymphoid lineage (HP:0012140)1.92269469
85Panhypogammaglobulinemia (HP:0003139)1.91994423
86Lactic acidosis (HP:0003128)1.88586854
87Meningitis (HP:0001287)1.87811310
88Cerebral palsy (HP:0100021)1.87599782
89Obstructive lung disease (HP:0006536)1.86900302
90Chronic obstructive pulmonary disease (HP:0006510)1.86900302
91Mesomelia (HP:0003027)1.86677069
92Absent/shortened dynein arms (HP:0200106)1.86676400
93Dynein arm defect of respiratory motile cilia (HP:0012255)1.86676400
94Ketosis (HP:0001946)1.84435987
95Agammaglobulinemia (HP:0004432)1.83773965
96Lethargy (HP:0001254)1.83631065
97Aplasia/Hypoplasia of the ulna (HP:0006495)1.83416206
98True hermaphroditism (HP:0010459)1.82931038
99Abnormality of T cell physiology (HP:0011840)1.82704145
100Retinal dysplasia (HP:0007973)1.82198953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.86218726
2TESK25.72295280
3BCKDK5.52192931
4TXK4.25618854
5NME12.59754028
6FES2.26978822
7ZAK2.15351579
8VRK22.11058953
9ITK2.04817277
10LIMK12.01343850
11TESK11.99856796
12TLK11.99573047
13TAOK31.89799924
14MAP4K11.85040519
15GRK11.80261539
16SYK1.78802954
17ADRBK21.77894580
18VRK11.59049820
19TAOK21.57269408
20MAP3K91.57074407
21CSK1.49846392
22MAP3K121.47527586
23TYRO31.41442607
24SCYL21.38998031
25PASK1.20907577
26PINK11.18057739
27PAK61.16001575
28GRK71.15027471
29GRK61.13560659
30PRKCQ1.12991223
31MAP4K21.12866262
32ZAP701.10229138
33TEC1.09582646
34LCK1.06305888
35TNK21.04789725
36BUB10.95026680
37MUSK0.94661552
38BTK0.91297236
39FRK0.91040532
40RPS6KA50.88570909
41MOS0.88151125
42MAP3K110.86950003
43NUAK10.86173014
44IKBKE0.82729860
45LYN0.82482995
46CAMKK20.79355289
47WNK40.78844414
48PIM10.75777874
49STK160.74880396
50MYLK0.74272325
51PIK3CA0.70840093
52PIK3CG0.69157976
53IKBKB0.63871737
54CAMKK10.62910323
55TGFBR20.62519727
56EIF2AK30.60260506
57INSRR0.59146458
58ROCK10.58712358
59RPS6KA40.57679805
60DAPK10.57630491
61MAPKAPK30.56798006
62MAP3K70.56708860
63FYN0.55343287
64OBSCN0.50266237
65CSF1R0.47290144
66TIE10.44154377
67PRKCA0.44138695
68PIM20.41590279
69TBK10.41506416
70KIT0.40189134
71NTRK30.39526586
72MAPK130.39486220
73AURKA0.39211519
74INSR0.37220724
75LRRK20.36630397
76IGF1R0.36254515
77PRPF4B0.35962509
78PRKCH0.35344973
79PRKACA0.35326793
80CAMK2A0.35007381
81CLK10.34888740
82ADRBK10.34012709
83CSNK2A10.31784879
84MAP2K70.31365266
85MAP2K60.30985628
86MST40.26830902
87DYRK20.26567555
88PRKCD0.25865695
89NTRK20.25780656
90CDK80.25548288
91MAPKAPK50.23227013
92TAOK10.22907765
93WNK30.22613498
94PAK10.21608628
95HCK0.20292463
96PRKCG0.19911634
97EPHB20.19514688
98ABL10.19426411
99CSNK1G30.19361836
100RAF10.18953525

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.96475147
2Proteasome_Homo sapiens_hsa030503.78811258
3Oxidative phosphorylation_Homo sapiens_hsa001903.52506089
4Parkinsons disease_Homo sapiens_hsa050122.91922914
5Antigen processing and presentation_Homo sapiens_hsa046122.89634412
6Graft-versus-host disease_Homo sapiens_hsa053322.84406482
7Ribosome_Homo sapiens_hsa030102.83832271
8Autoimmune thyroid disease_Homo sapiens_hsa053202.51146976
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.49004850
10Hematopoietic cell lineage_Homo sapiens_hsa046402.46922900
11Allograft rejection_Homo sapiens_hsa053302.39223597
12T cell receptor signaling pathway_Homo sapiens_hsa046602.30402624
13Phototransduction_Homo sapiens_hsa047442.30200261
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.12724652
15Alzheimers disease_Homo sapiens_hsa050102.12013630
16Type I diabetes mellitus_Homo sapiens_hsa049402.00465024
17Cardiac muscle contraction_Homo sapiens_hsa042601.96427714
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.91170647
19Huntingtons disease_Homo sapiens_hsa050161.80006613
20RNA polymerase_Homo sapiens_hsa030201.40122004
21Peroxisome_Homo sapiens_hsa041461.33716524
22Rheumatoid arthritis_Homo sapiens_hsa053231.33041396
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31569599
24Nitrogen metabolism_Homo sapiens_hsa009101.31095120
25Fanconi anemia pathway_Homo sapiens_hsa034601.26672917
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23206620
27Linoleic acid metabolism_Homo sapiens_hsa005911.22493800
28Measles_Homo sapiens_hsa051621.21953708
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.17938405
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15826879
31Viral myocarditis_Homo sapiens_hsa054161.15348280
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10974331
33Protein export_Homo sapiens_hsa030601.09546978
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09253691
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.08327797
36Caffeine metabolism_Homo sapiens_hsa002321.07549810
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05978041
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03116962
39Salmonella infection_Homo sapiens_hsa051321.00672534
40Malaria_Homo sapiens_hsa051441.00583235
41Asthma_Homo sapiens_hsa053100.98451475
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93895249
43Homologous recombination_Homo sapiens_hsa034400.92285724
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91815837
45RNA degradation_Homo sapiens_hsa030180.90740766
46Shigellosis_Homo sapiens_hsa051310.90146143
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88946888
48Propanoate metabolism_Homo sapiens_hsa006400.88191355
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.86214684
50Retinol metabolism_Homo sapiens_hsa008300.83455007
51Chemical carcinogenesis_Homo sapiens_hsa052040.81141662
52Nicotine addiction_Homo sapiens_hsa050330.79970116
53Systemic lupus erythematosus_Homo sapiens_hsa053220.77191401
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74399913
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69061910
56One carbon pool by folate_Homo sapiens_hsa006700.65119177
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62461047
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62083314
59Olfactory transduction_Homo sapiens_hsa047400.61043031
60Prion diseases_Homo sapiens_hsa050200.60311571
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56957095
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.56021621
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51535215
64Pyrimidine metabolism_Homo sapiens_hsa002400.50708116
65Purine metabolism_Homo sapiens_hsa002300.47914662
66Butanoate metabolism_Homo sapiens_hsa006500.47596390
67Mismatch repair_Homo sapiens_hsa034300.46856415
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.46821760
69Fat digestion and absorption_Homo sapiens_hsa049750.45178632
70Staphylococcus aureus infection_Homo sapiens_hsa051500.44916249
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43601878
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43535073
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43330448
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42785355
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42248615
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41907576
77Tryptophan metabolism_Homo sapiens_hsa003800.39522205
78Sulfur relay system_Homo sapiens_hsa041220.36162972
79Taste transduction_Homo sapiens_hsa047420.34403523
80Gastric acid secretion_Homo sapiens_hsa049710.31480918
81Chemokine signaling pathway_Homo sapiens_hsa040620.30497830
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28274258
83Metabolic pathways_Homo sapiens_hsa011000.27456046
84Mineral absorption_Homo sapiens_hsa049780.25574183
85Salivary secretion_Homo sapiens_hsa049700.24489793
86Arachidonic acid metabolism_Homo sapiens_hsa005900.21395559
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.20350536
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19876004
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19366593
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17987248
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.17962394
92ABC transporters_Homo sapiens_hsa020100.17525831
93Herpes simplex infection_Homo sapiens_hsa051680.17262216
94Alcoholism_Homo sapiens_hsa050340.17074650
95Endocytosis_Homo sapiens_hsa041440.16959775
96Nucleotide excision repair_Homo sapiens_hsa034200.14560163
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.14560008
98Regulation of autophagy_Homo sapiens_hsa041400.12484903
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.11970198
100HTLV-I infection_Homo sapiens_hsa051660.11523221

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