ATP5LP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.37011985
2kinetochore assembly (GO:0051382)5.23212420
3DNA deamination (GO:0045006)4.60545947
4protein polyglutamylation (GO:0018095)4.34253315
5regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.33719125
6regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.33719125
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.23201803
8kinetochore organization (GO:0051383)4.23175512
9gamma-aminobutyric acid transport (GO:0015812)4.13073466
10response to pheromone (GO:0019236)4.12673806
11protein-cofactor linkage (GO:0018065)4.08509613
12substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.08162515
13substrate-independent telencephalic tangential migration (GO:0021826)4.08162515
14negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.96973540
15regulation of vacuole organization (GO:0044088)3.95312067
16protein complex biogenesis (GO:0070271)3.88832078
17regulation of mitotic spindle checkpoint (GO:1903504)3.74891573
18regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.74891573
19left/right pattern formation (GO:0060972)3.74587973
20lysosome localization (GO:0032418)3.66528630
21RNA destabilization (GO:0050779)3.65582095
22axoneme assembly (GO:0035082)3.62334831
23regulation of natural killer cell mediated immunity (GO:0002715)3.58827793
24regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.58827793
25positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.54087499
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.50683801
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.50683801
28NADH dehydrogenase complex assembly (GO:0010257)3.50683801
29positive regulation of defense response to virus by host (GO:0002230)3.50012142
30mast cell degranulation (GO:0043303)3.47813713
31mast cell activation involved in immune response (GO:0002279)3.47813713
32negative regulation of organelle assembly (GO:1902116)3.42171286
33positive regulation of natural killer cell mediated immunity (GO:0002717)3.40406994
34mitochondrial respiratory chain complex assembly (GO:0033108)3.34965963
35regulation of neurotransmitter uptake (GO:0051580)3.33211768
36tolerance induction (GO:0002507)3.28026242
37epithelial cilium movement (GO:0003351)3.26219930
38negative regulation of cAMP-mediated signaling (GO:0043951)3.25673861
39CTP biosynthetic process (GO:0006241)3.17582896
40CTP metabolic process (GO:0046036)3.17582896
41positive regulation of prostaglandin secretion (GO:0032308)3.15611648
42ATP synthesis coupled proton transport (GO:0015986)3.11668228
43energy coupled proton transport, down electrochemical gradient (GO:0015985)3.11668228
44negative regulation of heart rate (GO:0010459)3.11512617
45regulation of leukocyte mediated cytotoxicity (GO:0001910)3.11245550
46cellular response to exogenous dsRNA (GO:0071360)3.06861674
47regulation of centriole replication (GO:0046599)3.04277178
48regulation of action potential (GO:0098900)3.04169724
49sleep (GO:0030431)2.95161462
50negative regulation of DNA-templated transcription, elongation (GO:0032785)2.94923529
51regulation of synaptic transmission, dopaminergic (GO:0032225)2.94398338
52chaperone-mediated protein transport (GO:0072321)2.93964392
53pyrimidine nucleobase catabolic process (GO:0006208)2.93592288
54proline transport (GO:0015824)2.92474775
55positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90983802
56regulation of cell killing (GO:0031341)2.90976821
57behavioral response to ethanol (GO:0048149)2.90537884
58cellular response to interferon-beta (GO:0035458)2.80188839
59regulation of respiratory burst (GO:0060263)2.79459292
60GTP biosynthetic process (GO:0006183)2.79196426
61cilium movement (GO:0003341)2.78792411
62positive regulation of fatty acid transport (GO:2000193)2.76699745
63cAMP catabolic process (GO:0006198)2.76555748
64synaptic transmission, dopaminergic (GO:0001963)2.73416742
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.72807778
66RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.72807778
67positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.72742063
68regulation of autophagic vacuole assembly (GO:2000785)2.72389430
69pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.72372836
70ubiquinone biosynthetic process (GO:0006744)2.72295411
71positive regulation of T cell apoptotic process (GO:0070234)2.71274806
72positive regulation of calcium-mediated signaling (GO:0050850)2.70316760
73deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.70103515
74GPI anchor metabolic process (GO:0006505)2.68972082
75regulation of hydrogen peroxide metabolic process (GO:0010310)2.67725557
76hypothalamus development (GO:0021854)2.67675074
77microtubule bundle formation (GO:0001578)2.67669433
78regulation of regulatory T cell differentiation (GO:0045589)2.67502008
79hydrogen ion transmembrane transport (GO:1902600)2.66922786
80somite development (GO:0061053)2.66462133
81ubiquinone metabolic process (GO:0006743)2.65455273
82negative regulation of meiotic cell cycle (GO:0051447)2.63866633
83isoprenoid biosynthetic process (GO:0008299)2.60915775
84negative regulation of telomere maintenance (GO:0032205)2.60398686
85positive regulation of cell killing (GO:0031343)2.60274868
86activated T cell proliferation (GO:0050798)2.60235865
87regulation of prostaglandin secretion (GO:0032306)2.59401044
88grooming behavior (GO:0007625)2.59173035
89cytidine metabolic process (GO:0046087)2.56777810
90cytidine catabolic process (GO:0006216)2.56777810
91cytidine deamination (GO:0009972)2.56777810
92synaptic vesicle maturation (GO:0016188)2.55214101
93mitochondrion distribution (GO:0048311)2.54923211
94mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.54452946
95GPI anchor biosynthetic process (GO:0006506)2.54109917
96respiratory electron transport chain (GO:0022904)2.53691084
97electron transport chain (GO:0022900)2.53613516
98transmission of nerve impulse (GO:0019226)2.52191953
99protein neddylation (GO:0045116)2.51213743
100pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.50567349

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.32892962
2VDR_22108803_ChIP-Seq_LS180_Human3.33090658
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.98185771
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.91961479
5IRF1_19129219_ChIP-ChIP_H3396_Human2.75888767
6ZNF274_21170338_ChIP-Seq_K562_Hela2.26291032
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.25290264
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21387388
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14859822
10MYC_18940864_ChIP-ChIP_HL60_Human1.97875384
11GABP_17652178_ChIP-ChIP_JURKAT_Human1.93589928
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93382391
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93220145
14ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84730905
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.83569046
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79222902
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.78662709
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71864049
19ERA_21632823_ChIP-Seq_H3396_Human1.70699262
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69806131
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.68145016
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62468027
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56619872
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54100076
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51508973
26RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.50338496
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50318475
28EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.48978339
29TDRD3_21172665_ChIP-Seq_MCF-7_Human1.46992555
30REST_21632747_ChIP-Seq_MESCs_Mouse1.45561201
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44853130
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44424475
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.42914057
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.40612193
35P300_27268052_Chip-Seq_Bcells_Human1.38834900
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38142313
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38058638
38ER_23166858_ChIP-Seq_MCF-7_Human1.37429420
39TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.36814197
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35240544
41GATA3_21878914_ChIP-Seq_MCF-7_Human1.35041054
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.34145681
43TP53_22573176_ChIP-Seq_HFKS_Human1.31009775
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30438828
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.29916313
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28338103
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28199714
48TAF2_19829295_ChIP-Seq_ESCs_Human1.27349645
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24318751
50PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.23020567
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21994747
52FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20686778
53GATA3_26560356_Chip-Seq_TH2_Human1.19064046
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18995098
55GATA3_21867929_ChIP-Seq_TH1_Mouse1.17616771
56NCOR_22424771_ChIP-Seq_293T_Human1.16770255
57CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15703564
58NANOG_20526341_ChIP-Seq_ESCs_Human1.15392502
59VDR_23849224_ChIP-Seq_CD4+_Human1.15194283
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.13246482
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11981134
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11639090
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10364595
64RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09049451
65BCL6_27268052_Chip-Seq_Bcells_Human1.08845186
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08464491
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07507572
68SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02131434
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01807759
70MYC_19829295_ChIP-Seq_ESCs_Human1.01759321
71RUNX_20019798_ChIP-Seq_JUKART_Human1.01547936
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01269226
73RNF2_27304074_Chip-Seq_NSC_Mouse1.00491824
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00399072
75SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99562521
76E2F1_20622854_ChIP-Seq_HELA_Human0.99477928
77HTT_18923047_ChIP-ChIP_STHdh_Human0.99198655
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99116553
79FOXP3_21729870_ChIP-Seq_TREG_Human0.97552289
80STAT1_20625510_ChIP-Seq_HELA_Human0.97192997
81P68_20966046_ChIP-Seq_HELA_Human0.96701049
82TCF4_22108803_ChIP-Seq_LS180_Human0.95944627
83CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93496873
84RAC3_21632823_ChIP-Seq_H3396_Human0.93485520
85ELK1_19687146_ChIP-ChIP_HELA_Human0.93226472
86HOXB7_26014856_ChIP-Seq_BT474_Human0.93136180
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92983888
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92168704
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91265947
90TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.90028502
91CTCF_20526341_ChIP-Seq_ESCs_Human0.89420141
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89069535
93ETS1_20019798_ChIP-Seq_JURKAT_Human0.88447411
94FOXH1_21741376_ChIP-Seq_EPCs_Human0.87386741
95EZH2_27294783_Chip-Seq_NPCs_Mouse0.86248178
96P300_19829295_ChIP-Seq_ESCs_Human0.86039579
97TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85747443
98TAL1_26923725_Chip-Seq_HPCs_Mouse0.84651677
99SA1_27219007_Chip-Seq_Bcells_Human0.84235611
100ERG_20517297_ChIP-Seq_VCAP_Human0.84031738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.41931108
2MP0003880_abnormal_central_pattern4.28554741
3MP0002822_catalepsy3.67432729
4MP0002653_abnormal_ependyma_morphology3.64006513
5MP0006276_abnormal_autonomic_nervous3.09787172
6MP0002138_abnormal_hepatobiliary_system3.00958413
7MP0005084_abnormal_gallbladder_morpholo2.78695707
8MP0006292_abnormal_olfactory_placode2.65462235
9MP0004147_increased_porphyrin_level2.28846563
10MP0009379_abnormal_foot_pigmentation2.24074697
11MP0004885_abnormal_endolymph2.14340253
12MP0005423_abnormal_somatic_nervous2.03806707
13MP0001905_abnormal_dopamine_level2.02263053
14MP0003787_abnormal_imprinting2.01365421
15MP0001188_hyperpigmentation1.96478115
16MP0005645_abnormal_hypothalamus_physiol1.92852178
17MP0005671_abnormal_response_to1.87263900
18MP0005646_abnormal_pituitary_gland1.85708907
19MP0002876_abnormal_thyroid_physiology1.80616402
20MP0009745_abnormal_behavioral_response1.78130473
21MP0002837_dystrophic_cardiac_calcinosis1.63425007
22MP0008877_abnormal_DNA_methylation1.60426501
23MP0008875_abnormal_xenobiotic_pharmacok1.56489147
24MP0001529_abnormal_vocalization1.52784295
25MP0003724_increased_susceptibility_to1.51490386
26MP0002272_abnormal_nervous_system1.49315422
27MP0002102_abnormal_ear_morphology1.47783717
28MP0002254_reproductive_system_inflammat1.45058025
29MP0001919_abnormal_reproductive_system1.44037008
30MP0000955_abnormal_spinal_cord1.39152367
31MP0005551_abnormal_eye_electrophysiolog1.35042652
32MP0002557_abnormal_social/conspecific_i1.34901813
33MP0003866_abnormal_defecation1.29810996
34MP0000685_abnormal_immune_system1.29462343
35MP0002928_abnormal_bile_duct1.24252916
36MP0005670_abnormal_white_adipose1.23646098
37MP0005389_reproductive_system_phenotype1.22594777
38MP0008775_abnormal_heart_ventricle1.22532360
39MP0003635_abnormal_synaptic_transmissio1.20828341
40MP0009046_muscle_twitch1.17837989
41MP0003646_muscle_fatigue1.15270369
42MP0002572_abnormal_emotion/affect_behav1.15213181
43MP0002733_abnormal_thermal_nociception1.14900017
44MP0004145_abnormal_muscle_electrophysio1.14822781
45MP0002234_abnormal_pharynx_morphology1.13979110
46MP0001970_abnormal_pain_threshold1.13379199
47MP0001485_abnormal_pinna_reflex1.08142951
48MP0002736_abnormal_nociception_after1.08076322
49MP0008872_abnormal_physiological_respon1.07784626
50MP0000778_abnormal_nervous_system1.03407457
51MP0006036_abnormal_mitochondrial_physio1.03256489
52MP0004924_abnormal_behavior1.03234008
53MP0005386_behavior/neurological_phenoty1.03234008
54MP0003693_abnormal_embryo_hatching1.03147941
55MP0001986_abnormal_taste_sensitivity1.02804939
56MP0001968_abnormal_touch/_nociception1.02011145
57MP0004043_abnormal_pH_regulation1.01847196
58MP0004142_abnormal_muscle_tone1.00915765
59MP0000631_abnormal_neuroendocrine_gland1.00875414
60MP0001790_abnormal_immune_system1.00749791
61MP0005387_immune_system_phenotype1.00749791
62MP0004859_abnormal_synaptic_plasticity0.98634915
63MP0005174_abnormal_tail_pigmentation0.96922069
64MP0003122_maternal_imprinting0.95018181
65MP0008569_lethality_at_weaning0.94377631
66MP0004133_heterotaxia0.94264281
67MP0005075_abnormal_melanosome_morpholog0.92435093
68MP0001293_anophthalmia0.91779304
69MP0000230_abnormal_systemic_arterial0.91385371
70MP0003878_abnormal_ear_physiology0.91155592
71MP0005377_hearing/vestibular/ear_phenot0.91155592
72MP0002067_abnormal_sensory_capabilities0.90883368
73MP0003763_abnormal_thymus_physiology0.90879970
74MP0003195_calcinosis0.90338244
75MP0000427_abnormal_hair_cycle0.90127998
76MP0004130_abnormal_muscle_cell0.89560008
77MP0002063_abnormal_learning/memory/cond0.88880163
78MP0008789_abnormal_olfactory_epithelium0.87595178
79MP0002752_abnormal_somatic_nervous0.87213952
80MP0002184_abnormal_innervation0.84587969
81MP0002734_abnormal_mechanical_nocicepti0.83700570
82MP0003123_paternal_imprinting0.82560364
83MP0006072_abnormal_retinal_apoptosis0.81365984
84MP0004742_abnormal_vestibular_system0.80629319
85MP0002229_neurodegeneration0.80242500
86MP0000613_abnormal_salivary_gland0.80223274
87MP0002064_seizures0.80168041
88MP0002735_abnormal_chemical_nociception0.80113824
89MP0003303_peritoneal_inflammation0.77987583
90MP0001486_abnormal_startle_reflex0.77947379
91MP0001501_abnormal_sleep_pattern0.77836554
92MP0005365_abnormal_bile_salt0.76374827
93MP0001542_abnormal_bone_strength0.75999942
94MP0006035_abnormal_mitochondrial_morpho0.75157101
95MP0005000_abnormal_immune_tolerance0.74197185
96MP0002882_abnormal_neuron_morphology0.73954099
97MP0005394_taste/olfaction_phenotype0.72298309
98MP0005499_abnormal_olfactory_system0.72298309
99MP0002938_white_spotting0.70540225
100MP0002160_abnormal_reproductive_system0.70441770

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)6.78147327
2Progressive cerebellar ataxia (HP:0002073)4.01067032
3Short tibia (HP:0005736)3.69766783
4Abnormality of magnesium homeostasis (HP:0004921)3.53978264
5Hypomagnesemia (HP:0002917)3.43113570
6Aplasia/Hypoplasia of the tibia (HP:0005772)3.40636721
7Abnormality of the labia minora (HP:0012880)3.16930415
8Generalized aminoaciduria (HP:0002909)3.13350652
9Abnormality of midbrain morphology (HP:0002418)3.02669486
10Molar tooth sign on MRI (HP:0002419)3.02669486
11Reticulocytopenia (HP:0001896)2.96623816
12Absent thumb (HP:0009777)2.92707630
13Renal cortical cysts (HP:0000803)2.91305539
14IgM deficiency (HP:0002850)2.89707990
15Abnormality of the renal cortex (HP:0011035)2.86894307
16IgG deficiency (HP:0004315)2.83322158
17Hyperphosphatemia (HP:0002905)2.79497666
18Abnormal mitochondria in muscle tissue (HP:0008316)2.79001843
19Progressive microcephaly (HP:0000253)2.77176304
20Increased CSF lactate (HP:0002490)2.75479381
21Congenital stationary night blindness (HP:0007642)2.74053860
22Acute necrotizing encephalopathy (HP:0006965)2.70089486
23Peritonitis (HP:0002586)2.69400404
24Shawl scrotum (HP:0000049)2.65134193
25B lymphocytopenia (HP:0010976)2.57165798
26Hypothermia (HP:0002045)2.54134120
27Hyperthyroidism (HP:0000836)2.53149227
28Pancreatic fibrosis (HP:0100732)2.46906427
29Acute encephalopathy (HP:0006846)2.44899640
30Hypoplasia of the pons (HP:0012110)2.41738047
31Papilledema (HP:0001085)2.38385283
32Mitochondrial inheritance (HP:0001427)2.37283414
33Abnormality of B cell number (HP:0010975)2.36786545
34Aplasia/Hypoplasia of the spleen (HP:0010451)2.35984399
35Nephronophthisis (HP:0000090)2.35819679
36Myokymia (HP:0002411)2.32219057
37Lipid accumulation in hepatocytes (HP:0006561)2.31443192
38Increased hepatocellular lipid droplets (HP:0006565)2.30589275
39Abnormality of the vocal cords (HP:0008777)2.23708995
40Abnormality of the pons (HP:0007361)2.22605208
41Asplenia (HP:0001746)2.22509330
42Ectopic kidney (HP:0000086)2.22233373
43Abnormality of the renal medulla (HP:0100957)2.13263978
44Tetany (HP:0001281)2.11941146
45Progressive macrocephaly (HP:0004481)2.11420646
46Hepatic necrosis (HP:0002605)2.10306392
47Abnormality of cells of the erythroid lineage (HP:0012130)2.09730398
48Agitation (HP:0000713)2.07681581
49Type 2 muscle fiber atrophy (HP:0003554)2.06796473
50Optic disc pallor (HP:0000543)2.04801089
51T lymphocytopenia (HP:0005403)1.99165560
52Abnormality of T cells (HP:0002843)1.98177666
53Down-sloping shoulders (HP:0200021)1.96487888
54Abnormal respiratory epithelium morphology (HP:0012253)1.96313262
55Abnormal respiratory motile cilium morphology (HP:0005938)1.96313262
56Increased intramyocellular lipid droplets (HP:0012240)1.96310722
57Pachygyria (HP:0001302)1.96119451
58Renal Fanconi syndrome (HP:0001994)1.92957168
59Fibular aplasia (HP:0002990)1.92030738
60Postaxial foot polydactyly (HP:0001830)1.91216727
61Abnormal number of erythroid precursors (HP:0012131)1.91135158
62Polyuria (HP:0000103)1.90488082
63Long clavicles (HP:0000890)1.89911410
64Decreased circulating renin level (HP:0003351)1.88958115
65Genetic anticipation (HP:0003743)1.86411553
66Hip dysplasia (HP:0001385)1.85606714
67Severe global developmental delay (HP:0011344)1.85087014
68Abnormality of urine glucose concentration (HP:0011016)1.84736031
69Glycosuria (HP:0003076)1.84736031
70Hypoplasia of the brainstem (HP:0002365)1.84439013
71Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84439013
72Pancreatic cysts (HP:0001737)1.83780552
73Fetal akinesia sequence (HP:0001989)1.82687402
74Abnormal ciliary motility (HP:0012262)1.82656900
75Abnormality of renal excretion (HP:0011036)1.81202455
76Neuroendocrine neoplasm (HP:0100634)1.80922196
77Muscle fiber atrophy (HP:0100295)1.80757115
78Hepatocellular necrosis (HP:0001404)1.80109220
79Abnormal urine output (HP:0012590)1.79853395
80Potter facies (HP:0002009)1.78918380
81Facial shape deformation (HP:0011334)1.78918380
82Median cleft lip (HP:0000161)1.76371202
83Bilateral microphthalmos (HP:0007633)1.75850028
84Inability to walk (HP:0002540)1.75379034
85Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75267436
86Increased serum lactate (HP:0002151)1.70847448
87Bronchiectasis (HP:0002110)1.70479641
88Panhypogammaglobulinemia (HP:0003139)1.70458399
89Recurrent bronchitis (HP:0002837)1.70014372
90Supranuclear gaze palsy (HP:0000605)1.69916457
91Medial flaring of the eyebrow (HP:0010747)1.68592342
92Rib fusion (HP:0000902)1.68495673
93Small hand (HP:0200055)1.68464704
94Increased muscle lipid content (HP:0009058)1.67844637
95Oligodactyly (hands) (HP:0001180)1.66877805
96True hermaphroditism (HP:0010459)1.66821054
97Porencephaly (HP:0002132)1.66777532
98Recurrent sinusitis (HP:0011108)1.66157581
99Hypochromic anemia (HP:0001931)1.65309008
100Opisthotonus (HP:0002179)1.64491254

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK167.78619053
2MAP4K25.76509514
3TLK13.42185263
4TESK23.34831781
5PINK13.16916015
6TXK2.46856867
7LIMK12.33373372
8BMPR1B2.07084261
9ARAF2.05084981
10ADRBK21.83665645
11MAPKAPK31.57720354
12MINK11.55822773
13ZAK1.55328920
14MAP3K91.52872416
15EPHB21.47766526
16PIK3CA1.42156523
17WNK31.41162271
18PKN11.39143330
19NUAK11.38395801
20TAOK31.34005234
21WNK41.33925830
22KDR1.30342094
23DYRK21.26428573
24TESK11.22570804
25MAP2K21.20784825
26BRAF1.20446452
27NEK11.17370136
28NTRK11.07584337
29TAOK11.06458058
30PIM21.04637828
31NTRK20.92757910
32GRK60.90291773
33PRKD20.88619698
34GRK10.85978111
35FRK0.84947447
36PHKG20.83190881
37PHKG10.83190881
38MARK10.82151019
39LATS10.81807448
40MAPK110.81763922
41TAF10.81212815
42SYK0.78842495
43FES0.77370844
44PRKCQ0.75963489
45PAK30.75751576
46FLT30.75165771
47MAP3K110.74603871
48BTK0.73143436
49TNK20.68452854
50DAPK20.65564361
51CDC70.64443084
52GRK50.63154871
53VRK20.61949770
54CAMKK20.60901389
55VRK10.60866830
56PRKCG0.58446408
57ICK0.58348325
58ERBB20.57757571
59TYRO30.56888503
60DYRK1B0.56163355
61STK110.55203225
62DYRK1A0.54076886
63CSK0.52662153
64DAPK10.51020852
65MAP4K10.49999182
66CDK140.49998988
67ITK0.49919114
68CSNK1G20.48194201
69LCK0.47417325
70UHMK10.46743079
71MAP2K70.45245062
72MAPK130.45113163
73BRSK20.43798931
74MARK30.43653161
75CHEK20.41730614
76PIM10.41299221
77MAP2K60.41216304
78CSNK1G30.40995441
79MATK0.37776012
80CSNK1A10.36325986
81PRKACA0.36204856
82INSRR0.34329359
83OXSR10.34168402
84CDK180.34080258
85ALK0.33734561
86PDK10.33676506
87CDK150.32865815
88CSNK1E0.31673113
89CDK50.30976285
90CDK11A0.29648917
91PRKCI0.29584359
92ADRBK10.28455871
93TBK10.28451704
94PLK10.28005029
95CSNK1A1L0.27380928
96CAMKK10.27364292
97PRKD10.27304081
98TIE10.27132591
99PDPK10.26461940
100CSNK1G10.26361099

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001305.08621138
2Primary immunodeficiency_Homo sapiens_hsa053403.80866830
3Oxidative phosphorylation_Homo sapiens_hsa001903.47364466
4Parkinsons disease_Homo sapiens_hsa050122.92833016
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.82138660
6Ribosome_Homo sapiens_hsa030102.72941633
7Phototransduction_Homo sapiens_hsa047442.70079780
8Nicotine addiction_Homo sapiens_hsa050332.35671037
9Cardiac muscle contraction_Homo sapiens_hsa042602.32977993
10Regulation of autophagy_Homo sapiens_hsa041402.05894992
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97307591
12Morphine addiction_Homo sapiens_hsa050321.93037300
13Sulfur relay system_Homo sapiens_hsa041221.78924752
14Linoleic acid metabolism_Homo sapiens_hsa005911.74499522
15Graft-versus-host disease_Homo sapiens_hsa053321.67673603
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.67507026
17Huntingtons disease_Homo sapiens_hsa050161.63676677
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61509533
19Alzheimers disease_Homo sapiens_hsa050101.60881657
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53834250
21Proteasome_Homo sapiens_hsa030501.53763385
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51975289
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.50502856
24Collecting duct acid secretion_Homo sapiens_hsa049661.38404221
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.35173427
26Fanconi anemia pathway_Homo sapiens_hsa034601.34937366
27RNA polymerase_Homo sapiens_hsa030201.34387460
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26999659
29T cell receptor signaling pathway_Homo sapiens_hsa046601.23635871
30RNA degradation_Homo sapiens_hsa030181.21703181
31GABAergic synapse_Homo sapiens_hsa047271.15971575
32Caffeine metabolism_Homo sapiens_hsa002321.14121946
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11924227
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.10261820
35Purine metabolism_Homo sapiens_hsa002301.06716728
36Chemical carcinogenesis_Homo sapiens_hsa052041.04933462
37Pyrimidine metabolism_Homo sapiens_hsa002401.04879101
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03679982
39Homologous recombination_Homo sapiens_hsa034401.01929174
40Oxytocin signaling pathway_Homo sapiens_hsa049211.00245208
41Antigen processing and presentation_Homo sapiens_hsa046120.95789567
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90134798
43Ether lipid metabolism_Homo sapiens_hsa005650.86272607
44Glycerolipid metabolism_Homo sapiens_hsa005610.85118679
45Axon guidance_Homo sapiens_hsa043600.84754187
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82741220
47Selenocompound metabolism_Homo sapiens_hsa004500.82718490
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79477797
49Type I diabetes mellitus_Homo sapiens_hsa049400.79400681
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77957458
51Circadian entrainment_Homo sapiens_hsa047130.76637330
52Autoimmune thyroid disease_Homo sapiens_hsa053200.75482025
53Synaptic vesicle cycle_Homo sapiens_hsa047210.74616434
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73121153
55Dorso-ventral axis formation_Homo sapiens_hsa043200.71323491
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69606508
57Butanoate metabolism_Homo sapiens_hsa006500.69148881
58Hematopoietic cell lineage_Homo sapiens_hsa046400.67275566
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.66499007
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65153621
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64411648
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.63279409
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61475100
64Serotonergic synapse_Homo sapiens_hsa047260.60834678
65Long-term depression_Homo sapiens_hsa047300.57119494
66Allograft rejection_Homo sapiens_hsa053300.56703219
67One carbon pool by folate_Homo sapiens_hsa006700.53044853
68Ovarian steroidogenesis_Homo sapiens_hsa049130.51262703
69Fat digestion and absorption_Homo sapiens_hsa049750.51221922
70Salivary secretion_Homo sapiens_hsa049700.50833766
71Notch signaling pathway_Homo sapiens_hsa043300.50537723
72Tryptophan metabolism_Homo sapiens_hsa003800.49736410
73Rheumatoid arthritis_Homo sapiens_hsa053230.47695453
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46256865
75Cholinergic synapse_Homo sapiens_hsa047250.44582344
76Asthma_Homo sapiens_hsa053100.44504081
77Olfactory transduction_Homo sapiens_hsa047400.42333989
78Nitrogen metabolism_Homo sapiens_hsa009100.41641146
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41317020
80Calcium signaling pathway_Homo sapiens_hsa040200.40515431
81Glutamatergic synapse_Homo sapiens_hsa047240.39529216
82Peroxisome_Homo sapiens_hsa041460.37918130
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35768159
84Shigellosis_Homo sapiens_hsa051310.35616659
85Metabolic pathways_Homo sapiens_hsa011000.35407741
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.35040713
87Retinol metabolism_Homo sapiens_hsa008300.35011280
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34038803
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32524943
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32027236
91cAMP signaling pathway_Homo sapiens_hsa040240.31893131
92Ras signaling pathway_Homo sapiens_hsa040140.29785458
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29521739
94Hedgehog signaling pathway_Homo sapiens_hsa043400.28327046
95Oocyte meiosis_Homo sapiens_hsa041140.27701115
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27683183
97MAPK signaling pathway_Homo sapiens_hsa040100.27451462
98beta-Alanine metabolism_Homo sapiens_hsa004100.25957074
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25943478
100Amphetamine addiction_Homo sapiens_hsa050310.25494957

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