ATP5S

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.41940920
2ATP synthesis coupled proton transport (GO:0015986)5.99397985
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.99397985
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.92595911
5respiratory electron transport chain (GO:0022904)5.23263365
6behavioral response to nicotine (GO:0035095)5.16070083
7electron transport chain (GO:0022900)5.13639743
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.63741707
9chaperone-mediated protein transport (GO:0072321)4.44681388
10protein complex biogenesis (GO:0070271)4.18939947
11mitochondrial respiratory chain complex I assembly (GO:0032981)4.15362510
12NADH dehydrogenase complex assembly (GO:0010257)4.15362510
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.15362510
14response to pheromone (GO:0019236)4.04310909
15GTP biosynthetic process (GO:0006183)3.88044080
16mitochondrial respiratory chain complex assembly (GO:0033108)3.82013777
17indolalkylamine metabolic process (GO:0006586)3.77243614
18indole-containing compound catabolic process (GO:0042436)3.72893974
19indolalkylamine catabolic process (GO:0046218)3.72893974
20tryptophan catabolic process (GO:0006569)3.72893974
21dopamine transport (GO:0015872)3.72345891
22axoneme assembly (GO:0035082)3.68772601
23epithelial cilium movement (GO:0003351)3.68106796
24* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.62019564
25* purine nucleoside triphosphate biosynthetic process (GO:0009145)3.59008656
26kynurenine metabolic process (GO:0070189)3.57537944
27cilium movement (GO:0003341)3.55117785
28* ATP biosynthetic process (GO:0006754)3.54365295
29guanosine-containing compound biosynthetic process (GO:1901070)3.50215094
30* hydrogen ion transmembrane transport (GO:1902600)3.49349257
31proteasome assembly (GO:0043248)3.49157542
32cullin deneddylation (GO:0010388)3.47859210
33oxidative phosphorylation (GO:0006119)3.46131160
34detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.33988619
35protein-cofactor linkage (GO:0018065)3.31938693
36fucose catabolic process (GO:0019317)3.29793025
37L-fucose metabolic process (GO:0042354)3.29793025
38L-fucose catabolic process (GO:0042355)3.29793025
39regulation of oxidative phosphorylation (GO:0002082)3.29348958
40respiratory chain complex IV assembly (GO:0008535)3.26956705
41sulfation (GO:0051923)3.24518005
42protein deneddylation (GO:0000338)3.22582243
43tryptophan metabolic process (GO:0006568)3.22549473
44L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.19861422
45protein K11-linked deubiquitination (GO:0035871)3.19026200
46protein targeting to mitochondrion (GO:0006626)3.18985767
47neural tube formation (GO:0001841)3.17445076
48protein neddylation (GO:0045116)3.16591718
49* proton transport (GO:0015992)3.15412979
50energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.14317049
51ATP hydrolysis coupled proton transport (GO:0015991)3.14317049
52cellular ketone body metabolic process (GO:0046950)3.13204669
53UTP biosynthetic process (GO:0006228)3.13135766
54regulation of synapse structural plasticity (GO:0051823)3.12607326
55behavioral response to ethanol (GO:0048149)3.12464384
56* ribonucleoside triphosphate biosynthetic process (GO:0009201)3.11849021
57detection of light stimulus involved in visual perception (GO:0050908)3.11774430
58detection of light stimulus involved in sensory perception (GO:0050962)3.11774430
59establishment of protein localization to mitochondrion (GO:0072655)3.10320625
60* hydrogen transport (GO:0006818)3.08046358
61neuron cell-cell adhesion (GO:0007158)3.03668735
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03555908
63regulation of action potential (GO:0098900)3.03348711
64indole-containing compound metabolic process (GO:0042430)3.03254400
65regulation of catecholamine metabolic process (GO:0042069)3.02839175
66regulation of dopamine metabolic process (GO:0042053)3.02839175
67establishment of protein localization to mitochondrial membrane (GO:0090151)3.01246309
68ribosomal small subunit assembly (GO:0000028)2.99467532
69presynaptic membrane assembly (GO:0097105)2.99185998
70serotonin metabolic process (GO:0042428)2.97694667
71inner mitochondrial membrane organization (GO:0007007)2.95985051
72platelet dense granule organization (GO:0060155)2.95589144
73neurotransmitter uptake (GO:0001504)2.93137507
74reflex (GO:0060004)2.92168176
75termination of RNA polymerase III transcription (GO:0006386)2.92102612
76transcription elongation from RNA polymerase III promoter (GO:0006385)2.92102612
77gamma-aminobutyric acid transport (GO:0015812)2.91122821
78primary amino compound metabolic process (GO:1901160)2.90516708
79protein localization to mitochondrion (GO:0070585)2.88777351
80UTP metabolic process (GO:0046051)2.88292395
81aerobic respiration (GO:0009060)2.86322863
82interkinetic nuclear migration (GO:0022027)2.85737437
83daunorubicin metabolic process (GO:0044597)2.83465217
84polyketide metabolic process (GO:0030638)2.83465217
85doxorubicin metabolic process (GO:0044598)2.83465217
86neuronal action potential (GO:0019228)2.82154470
87amine catabolic process (GO:0009310)2.81563016
88cellular biogenic amine catabolic process (GO:0042402)2.81563016
89regulation of mitochondrial translation (GO:0070129)2.80511597
90DNA deamination (GO:0045006)2.80469631
91ketone body metabolic process (GO:1902224)2.79379554
92cilium organization (GO:0044782)2.79376864
93metallo-sulfur cluster assembly (GO:0031163)2.78104533
94iron-sulfur cluster assembly (GO:0016226)2.78104533
95water-soluble vitamin biosynthetic process (GO:0042364)2.77982960
96NADH metabolic process (GO:0006734)2.76532517
97* nucleoside triphosphate biosynthetic process (GO:0009142)2.76178977
98membrane depolarization during action potential (GO:0086010)2.75388534
99synaptic transmission, dopaminergic (GO:0001963)2.74976268
100negative regulation of cytosolic calcium ion concentration (GO:0051481)2.74876534
101regulation of cellular amino acid metabolic process (GO:0006521)2.74863959
102cilium assembly (GO:0042384)2.73235247
103synaptic vesicle exocytosis (GO:0016079)2.72746659
104behavioral response to cocaine (GO:0048148)2.72276775
105protein localization to cilium (GO:0061512)2.71123133
106cilium morphogenesis (GO:0060271)2.70581477
107axonemal dynein complex assembly (GO:0070286)2.70268715
108establishment of melanosome localization (GO:0032401)2.68385633
109negative regulation of mast cell activation (GO:0033004)2.68321113
110cytochrome complex assembly (GO:0017004)2.67975962
111negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.67005003
112dopamine biosynthetic process (GO:0042416)2.66137510
113deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.66039859
114presynaptic membrane organization (GO:0097090)2.65131271
115photoreceptor cell maintenance (GO:0045494)2.63250303
116adaptation of signaling pathway (GO:0023058)2.63126909
117nonmotile primary cilium assembly (GO:0035058)2.62680589
118CTP metabolic process (GO:0046036)2.62009240
119CTP biosynthetic process (GO:0006241)2.62009240
120quinone biosynthetic process (GO:1901663)2.61137362
121ubiquinone biosynthetic process (GO:0006744)2.61137362
122melanosome transport (GO:0032402)2.60396656
123regulation of cilium movement (GO:0003352)2.59809823
124methionine biosynthetic process (GO:0009086)2.58018073
125regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.57784315
126regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.57784315
1277-methylguanosine mRNA capping (GO:0006370)2.57121409
128establishment of integrated proviral latency (GO:0075713)2.56405926
129cotranslational protein targeting to membrane (GO:0006613)2.56390394
130establishment of pigment granule localization (GO:0051905)2.56132462
131postsynaptic membrane organization (GO:0001941)2.55969426
132regulation of hippo signaling (GO:0035330)2.55928502
133mitochondrial transport (GO:0006839)2.54394279
134amino acid salvage (GO:0043102)2.54081885
135L-methionine salvage (GO:0071267)2.54081885
136L-methionine biosynthetic process (GO:0071265)2.54081885
137motile cilium assembly (GO:0044458)2.53692695
138succinate metabolic process (GO:0006105)2.53643388
139GDP-mannose metabolic process (GO:0019673)2.53251212
140RNA capping (GO:0036260)2.52563537
1417-methylguanosine RNA capping (GO:0009452)2.52563537
142signal peptide processing (GO:0006465)2.52554025
143tachykinin receptor signaling pathway (GO:0007217)2.52199561
144response to histamine (GO:0034776)2.51372997
145transmission of nerve impulse (GO:0019226)2.50640105
146cilium or flagellum-dependent cell motility (GO:0001539)2.50619638
147neuronal action potential propagation (GO:0019227)2.50256259
148protein localization to endoplasmic reticulum (GO:0070972)2.50151101
149negative regulation of ligase activity (GO:0051352)2.49619380
150cAMP catabolic process (GO:0006198)2.48906409
151G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.48039697
152benzene-containing compound metabolic process (GO:0042537)2.47999419
153piRNA metabolic process (GO:0034587)2.47299436
154establishment of protein localization to Golgi (GO:0072600)2.46971066
155NAD biosynthetic process (GO:0009435)2.45397754
156multicellular organism reproduction (GO:0032504)2.45128309
157cyclic nucleotide catabolic process (GO:0009214)2.44223628
158regulation of neurotransmitter uptake (GO:0051580)2.43514934
159spinal cord motor neuron differentiation (GO:0021522)2.42916817
160regulation of skeletal muscle contraction (GO:0014819)2.41700870
161kidney morphogenesis (GO:0060993)2.40474486
162negative regulation of neurotransmitter transport (GO:0051589)2.40317802
163thyroid hormone metabolic process (GO:0042403)2.40285703
164positive regulation of oligodendrocyte differentiation (GO:0048714)2.39145881
165negative regulation of appetite (GO:0032099)2.38986144
166negative regulation of response to food (GO:0032096)2.38986144
167protein polyglutamylation (GO:0018095)2.38898489
168preassembly of GPI anchor in ER membrane (GO:0016254)2.37463137
169regulation of rhodopsin mediated signaling pathway (GO:0022400)2.36956832
170cornea development in camera-type eye (GO:0061303)2.36840325
171startle response (GO:0001964)2.36464459
172negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.35449411
173negative regulation of translation, ncRNA-mediated (GO:0040033)2.35449411
174regulation of translation, ncRNA-mediated (GO:0045974)2.35449411
175regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.35101460
176rhodopsin mediated signaling pathway (GO:0016056)2.34241000
177DNA demethylation (GO:0080111)2.34093570
178oxidative demethylation (GO:0070989)2.33611938
179reciprocal DNA recombination (GO:0035825)2.32344033
180reciprocal meiotic recombination (GO:0007131)2.32344033
181cellular component assembly involved in morphogenesis (GO:0010927)2.32239553
182cytidine metabolic process (GO:0046087)2.31504511
183cytidine catabolic process (GO:0006216)2.31504511
184cytidine deamination (GO:0009972)2.31504511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.62382163
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.49845402
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.30237892
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.25601232
5EZH2_22144423_ChIP-Seq_EOC_Human3.11573673
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.06446332
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.04091371
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.99930558
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.84991618
10TAF15_26573619_Chip-Seq_HEK293_Human2.82289825
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.80942715
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69911583
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.62740286
14GBX2_23144817_ChIP-Seq_PC3_Human2.58472939
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.51688296
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.50990373
17VDR_22108803_ChIP-Seq_LS180_Human2.47668303
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.43804942
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20504587
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14278401
21* SRF_21415370_ChIP-Seq_HL-1_Mouse2.13900590
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12359636
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10517551
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09636362
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03139880
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.97786613
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92618472
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81319767
29FUS_26573619_Chip-Seq_HEK293_Human1.77946642
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76128182
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.74100880
32VDR_23849224_ChIP-Seq_CD4+_Human1.73892798
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72678984
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.71654272
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.70755105
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69565770
37* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69340392
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69226968
39STAT3_23295773_ChIP-Seq_U87_Human1.68246654
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67800830
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65710309
42SMAD4_21799915_ChIP-Seq_A2780_Human1.65471107
43BCAT_22108803_ChIP-Seq_LS180_Human1.64775598
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64550585
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61732137
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60461749
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57772333
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.55933126
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54705302
50TCF4_23295773_ChIP-Seq_U87_Human1.54498507
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53211187
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53211187
53ZNF274_21170338_ChIP-Seq_K562_Hela1.50677218
54AR_25329375_ChIP-Seq_VCAP_Human1.50185590
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.49516186
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48599194
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48558541
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47711031
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46842851
60CBP_20019798_ChIP-Seq_JUKART_Human1.45948101
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45948101
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45185781
63AR_21572438_ChIP-Seq_LNCaP_Human1.38658921
64REST_21632747_ChIP-Seq_MESCs_Mouse1.37498636
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36053703
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33386108
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32824129
68TCF4_22108803_ChIP-Seq_LS180_Human1.29250436
69FOXP3_21729870_ChIP-Seq_TREG_Human1.28544355
70IGF1R_20145208_ChIP-Seq_DFB_Human1.27033293
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.26865574
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.26314121
73E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26007799
74P300_19829295_ChIP-Seq_ESCs_Human1.25933122
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25870428
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.25645274
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25548750
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.25346220
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.24113617
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.23345244
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22602367
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22570766
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22525016
84DCP1A_22483619_ChIP-Seq_HELA_Human1.22180957
85EWS_26573619_Chip-Seq_HEK293_Human1.21886989
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21228420
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20585533
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.19938193
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19938193
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19642085
91REST_18959480_ChIP-ChIP_MESCs_Mouse1.18158967
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17716264
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.17126049
94ELK1_19687146_ChIP-ChIP_HELA_Human1.16710422
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16646472
96* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16349357
97RUNX2_22187159_ChIP-Seq_PCA_Human1.16194251
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15808181
99FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13303110
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13090621
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.13067882
102FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12937372
103SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12791850
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12203144
105ER_23166858_ChIP-Seq_MCF-7_Human1.12073920
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11948930
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.11911313
108GABP_19822575_ChIP-Seq_HepG2_Human1.11355108
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.10804667
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10415696
111DROSHA_22980978_ChIP-Seq_HELA_Human1.09162330
112CRX_20693478_ChIP-Seq_RETINA_Mouse1.09069087
113* TTF2_22483619_ChIP-Seq_HELA_Human1.08322945
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07915469
115NCOR_22424771_ChIP-Seq_293T_Human1.07547786
116SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07403958
117MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06174702
118GATA3_21878914_ChIP-Seq_MCF-7_Human1.05407987
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04685900
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04052091
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03425796
122IRF1_19129219_ChIP-ChIP_H3396_Human1.03401917
123CDX2_22108803_ChIP-Seq_LS180_Human1.02017783
124SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01399248
125ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00386732
126HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00014559
127SOX2_21211035_ChIP-Seq_LN229_Gbm0.99956016
128HTT_18923047_ChIP-ChIP_STHdh_Human0.99631728
129MYC_18940864_ChIP-ChIP_HL60_Human0.99627761
130NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99007697
131AR_20517297_ChIP-Seq_VCAP_Human0.98700614
132CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98200067
133E2F1_18555785_Chip-Seq_ESCs_Mouse0.97909977
134CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97442261
135HOXB7_26014856_ChIP-Seq_BT474_Human0.97006610
136* NANOG_19829295_ChIP-Seq_ESCs_Human0.96294356
137* SOX2_19829295_ChIP-Seq_ESCs_Human0.96294356
138STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95491677
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95051929
140OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94895388
141ARNT_22903824_ChIP-Seq_MCF-7_Human0.94395307
142SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94116559
143FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93804829
144JUN_21703547_ChIP-Seq_K562_Human0.93275824
145P53_22387025_ChIP-Seq_ESCs_Mouse0.93123081
146JARID2_20064375_ChIP-Seq_MESCs_Mouse0.92668419
147ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91782754
148EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91734606
149TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89856185
150PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88628302
151* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88501964
152REST_19997604_ChIP-ChIP_NEURONS_Mouse0.88242696
153XRN2_22483619_ChIP-Seq_HELA_Human0.87778254
154STAT3_18555785_Chip-Seq_ESCs_Mouse0.87700102
155RNF2_27304074_Chip-Seq_NSC_Mouse0.87426392
156TP53_22573176_ChIP-Seq_HFKS_Human0.86475648
157ELK1_22589737_ChIP-Seq_MCF10A_Human0.86287838
158UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85495744
159CBX2_27304074_Chip-Seq_ESCs_Mouse0.84689353
160ERG_20517297_ChIP-Seq_VCAP_Human0.84416606
161EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.83630506
162SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83278242
163SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82771024

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.12974608
2MP0001529_abnormal_vocalization3.49039723
3MP0000569_abnormal_digit_pigmentation3.05968770
4MP0001968_abnormal_touch/_nociception2.83573406
5MP0002736_abnormal_nociception_after2.80664927
6MP0003195_calcinosis2.77502023
7MP0001984_abnormal_olfaction2.70199486
8MP0001905_abnormal_dopamine_level2.63226858
9MP0002837_dystrophic_cardiac_calcinosis2.52799951
10MP0009745_abnormal_behavioral_response2.45314877
11MP0005423_abnormal_somatic_nervous2.43601862
12MP0002272_abnormal_nervous_system2.34975069
13MP0006276_abnormal_autonomic_nervous2.32549500
14MP0006036_abnormal_mitochondrial_physio2.26722697
15MP0003635_abnormal_synaptic_transmissio2.24116836
16MP0003879_abnormal_hair_cell2.22287083
17MP0004270_analgesia2.21610653
18MP0002064_seizures2.16961401
19MP0009379_abnormal_foot_pigmentation2.13749350
20MP0004147_increased_porphyrin_level2.09365896
21MP0004859_abnormal_synaptic_plasticity2.06993649
22MP0005379_endocrine/exocrine_gland_phen2.06033421
23MP0005410_abnormal_fertilization2.04546182
24MP0002734_abnormal_mechanical_nocicepti2.00999522
25MP0002572_abnormal_emotion/affect_behav1.99997636
26MP0009046_muscle_twitch1.92921242
27MP0003136_yellow_coat_color1.90917062
28MP0002063_abnormal_learning/memory/cond1.90106051
29MP0002653_abnormal_ependyma_morphology1.86380452
30MP0008877_abnormal_DNA_methylation1.78011086
31MP0001486_abnormal_startle_reflex1.77100309
32MP0004215_abnormal_myocardial_fiber1.76387474
33MP0004130_abnormal_muscle_cell1.68354994
34MP0001986_abnormal_taste_sensitivity1.67758587
35MP0004142_abnormal_muscle_tone1.62689659
36MP0001188_hyperpigmentation1.60283796
37MP0005646_abnormal_pituitary_gland1.58254571
38MP0005174_abnormal_tail_pigmentation1.56420280
39MP0001501_abnormal_sleep_pattern1.56286093
40MP0006035_abnormal_mitochondrial_morpho1.53413773
41MP0003122_maternal_imprinting1.53095244
42MP0001970_abnormal_pain_threshold1.51904392
43MP0008875_abnormal_xenobiotic_pharmacok1.51523226
44MP0002735_abnormal_chemical_nociception1.50272111
45MP0002067_abnormal_sensory_capabilities1.50140219
46MP0002876_abnormal_thyroid_physiology1.48204828
47MP0009697_abnormal_copulation1.48198866
48MP0005253_abnormal_eye_physiology1.47119770
49MP0002163_abnormal_gland_morphology1.47072289
50MP0005409_darkened_coat_color1.46928971
51MP0002733_abnormal_thermal_nociception1.46172874
52MP0003123_paternal_imprinting1.45815971
53MP0004043_abnormal_pH_regulation1.44484797
54MP0002909_abnormal_adrenal_gland1.39220163
55MP0006292_abnormal_olfactory_placode1.38899951
56MP0001440_abnormal_grooming_behavior1.38714036
57MP0000427_abnormal_hair_cycle1.36798532
58MP0000372_irregular_coat_pigmentation1.36044517
59MP0003011_delayed_dark_adaptation1.34142615
60MP0003787_abnormal_imprinting1.32647484
61MP0004145_abnormal_muscle_electrophysio1.32182841
62MP0002160_abnormal_reproductive_system1.28456925
63MP0008872_abnormal_physiological_respon1.27619497
64MP0000751_myopathy1.24891627
65MP0005645_abnormal_hypothalamus_physiol1.24615913
66MP0002557_abnormal_social/conspecific_i1.23632460
67MP0005389_reproductive_system_phenotype1.19778630
68MP0005171_absent_coat_pigmentation1.19221273
69MP0004036_abnormal_muscle_relaxation1.18487943
70MP0005167_abnormal_blood-brain_barrier1.16305300
71MP0003186_abnormal_redox_activity1.15837550
72MP0004133_heterotaxia1.14279794
73MP0003698_abnormal_male_reproductive1.13742477
74MP0004924_abnormal_behavior1.12850536
75MP0005386_behavior/neurological_phenoty1.12850536
76MP0004885_abnormal_endolymph1.12613101
77MP0002822_catalepsy1.10990847
78MP0003656_abnormal_erythrocyte_physiolo1.09743841
79MP0008961_abnormal_basal_metabolism1.07416307
80MP0001485_abnormal_pinna_reflex1.05957745
81MP0003646_muscle_fatigue1.03851696
82MP0002928_abnormal_bile_duct1.03585798
83MP0008057_abnormal_DNA_replication1.02983359
84MP0002102_abnormal_ear_morphology1.02816331
85MP0001664_abnormal_digestion1.01666618
86MP0010386_abnormal_urinary_bladder1.01315438
87MP0002638_abnormal_pupillary_reflex0.99501844
88MP0003718_maternal_effect0.97288325
89MP0005075_abnormal_melanosome_morpholog0.96456503
90MP0002229_neurodegeneration0.96124057
91MP0001963_abnormal_hearing_physiology0.94788693
92MP0002066_abnormal_motor_capabilities/c0.93887105
93MP0005636_abnormal_mineral_homeostasis0.93429486
94MP0003121_genomic_imprinting0.93144220
95MP0000383_abnormal_hair_follicle0.93111848
96MP0008569_lethality_at_weaning0.92934586
97MP0005535_abnormal_body_temperature0.92794940
98MP0008775_abnormal_heart_ventricle0.92366914
99MP0005084_abnormal_gallbladder_morpholo0.91228411
100MP0002184_abnormal_innervation0.89644803
101MP0004742_abnormal_vestibular_system0.89113669
102MP0000013_abnormal_adipose_tissue0.88945682
103MP0002938_white_spotting0.86936716
104MP0002693_abnormal_pancreas_physiology0.86854516
105MP0000631_abnormal_neuroendocrine_gland0.86344208
106MP0001929_abnormal_gametogenesis0.85976298
107MP0000749_muscle_degeneration0.85224415
108MP0005266_abnormal_metabolism0.85010569
109MP0001764_abnormal_homeostasis0.84866893
110MP0008260_abnormal_autophagy0.83482640
111MP0001919_abnormal_reproductive_system0.83464427
112MP0000230_abnormal_systemic_arterial0.83243646
113MP0003045_fibrosis0.82521124
114MP0004085_abnormal_heartbeat0.82515144
115MP0000920_abnormal_myelination0.82148749
116MP0003806_abnormal_nucleotide_metabolis0.81806107
117MP0002095_abnormal_skin_pigmentation0.80989695
118MP0003252_abnormal_bile_duct0.80548451
119MP0005195_abnormal_posterior_eye0.80547867
120MP0006072_abnormal_retinal_apoptosis0.78968330
121MP0005310_abnormal_salivary_gland0.78727495
122MP0005551_abnormal_eye_electrophysiolog0.78408399
123MP0001756_abnormal_urination0.77434231
124MP0003633_abnormal_nervous_system0.76540277
125MP0003329_amyloid_beta_deposits0.75683783
126MP0005330_cardiomyopathy0.75408115
127MP0002234_abnormal_pharynx_morphology0.74434836
128MP0010329_abnormal_lipoprotein_level0.74165736
129MP0005451_abnormal_body_composition0.73885970
130MP0002752_abnormal_somatic_nervous0.73392656
131MP0000015_abnormal_ear_pigmentation0.72823447
132MP0001765_abnormal_ion_homeostasis0.72644018
133MP0004484_altered_response_of0.70572554
134MP0002132_abnormal_respiratory_system0.70438266
135MP0002277_abnormal_respiratory_mucosa0.69139590
136MP0003137_abnormal_impulse_conducting0.67974576
137MP0000026_abnormal_inner_ear0.67443658
138MP0002882_abnormal_neuron_morphology0.66577221
139MP0008995_early_reproductive_senescence0.66302394

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.83887201
2Abnormal mitochondria in muscle tissue (HP:0008316)5.45570964
3Hepatocellular necrosis (HP:0001404)5.44644957
4Mitochondrial inheritance (HP:0001427)5.14776310
5Acute encephalopathy (HP:0006846)4.94339352
6Hepatic necrosis (HP:0002605)4.73923835
7Progressive macrocephaly (HP:0004481)4.71756249
8Increased CSF lactate (HP:0002490)4.53632892
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.78232807
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.78232807
11Increased hepatocellular lipid droplets (HP:0006565)3.68761890
12Congenital stationary night blindness (HP:0007642)3.63781177
13Hypothermia (HP:0002045)3.60400667
14Nephronophthisis (HP:0000090)3.58926031
153-Methylglutaconic aciduria (HP:0003535)3.56012794
16Lactic acidosis (HP:0003128)3.37521386
17Lipid accumulation in hepatocytes (HP:0006561)3.35708626
18Genetic anticipation (HP:0003743)3.35078011
19Renal Fanconi syndrome (HP:0001994)3.31866881
20Cerebral edema (HP:0002181)3.21631457
21Neuroendocrine neoplasm (HP:0100634)3.18390044
22Increased serum lactate (HP:0002151)3.15892440
23Progressive cerebellar ataxia (HP:0002073)3.14958086
24Abnormality of the renal medulla (HP:0100957)3.13814047
25Dynein arm defect of respiratory motile cilia (HP:0012255)3.12727247
26Absent/shortened dynein arms (HP:0200106)3.12727247
27Gaze-evoked nystagmus (HP:0000640)3.10795653
28Abnormality of the renal cortex (HP:0011035)3.08102996
29Exercise intolerance (HP:0003546)3.05133682
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.04328445
31Cystic liver disease (HP:0006706)3.03004424
32Increased intramyocellular lipid droplets (HP:0012240)3.02762215
33Abnormality of alanine metabolism (HP:0010916)3.01206355
34Hyperalaninemia (HP:0003348)3.01206355
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.01206355
36Leukodystrophy (HP:0002415)2.99341597
37Focal motor seizures (HP:0011153)2.98531637
38Respiratory failure (HP:0002878)2.94532814
39Abnormality of glycolysis (HP:0004366)2.88865894
40Increased serum pyruvate (HP:0003542)2.88865894
41Pheochromocytoma (HP:0002666)2.87296869
42Attenuation of retinal blood vessels (HP:0007843)2.85571651
43Chronic hepatic failure (HP:0100626)2.84425751
44Optic disc pallor (HP:0000543)2.81243390
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.80249651
46Retinal dysplasia (HP:0007973)2.77220672
47Abnormal number of erythroid precursors (HP:0012131)2.66628138
48Abnormal respiratory epithelium morphology (HP:0012253)2.65526909
49Abnormal respiratory motile cilium morphology (HP:0005938)2.65526909
50Medial flaring of the eyebrow (HP:0010747)2.64057711
51Polydipsia (HP:0001959)2.61991074
52Abnormal drinking behavior (HP:0030082)2.61991074
53Microvesicular hepatic steatosis (HP:0001414)2.60559783
54Increased muscle lipid content (HP:0009058)2.59148046
55Abolished electroretinogram (ERG) (HP:0000550)2.58586877
56Tubular atrophy (HP:0000092)2.56294636
57Abnormality of cells of the erythroid lineage (HP:0012130)2.52626938
58Decreased central vision (HP:0007663)2.49210767
59Pancreatic fibrosis (HP:0100732)2.47548294
60Large for gestational age (HP:0001520)2.44637836
61Epileptic encephalopathy (HP:0200134)2.43076487
62Hyperventilation (HP:0002883)2.42744875
63Abnormal ciliary motility (HP:0012262)2.42564844
64Gait imbalance (HP:0002141)2.41663410
65Abnormal rod and cone electroretinograms (HP:0008323)2.41236520
66Type I transferrin isoform profile (HP:0003642)2.40756108
67Abnormality of renal resorption (HP:0011038)2.36898977
68Abnormality of the heme biosynthetic pathway (HP:0010472)2.36788319
69Visual hallucinations (HP:0002367)2.36317640
70Anencephaly (HP:0002323)2.35787584
71Decreased circulating renin level (HP:0003351)2.35534691
72Clumsiness (HP:0002312)2.35208222
73Congenital primary aphakia (HP:0007707)2.34782727
74Emotional lability (HP:0000712)2.31643014
75Furrowed tongue (HP:0000221)2.30985393
76Nephrogenic diabetes insipidus (HP:0009806)2.30925056
77Sclerocornea (HP:0000647)2.30543504
78Protruding tongue (HP:0010808)2.29631868
79Atonic seizures (HP:0010819)2.26750313
80Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25874532
81Pendular nystagmus (HP:0012043)2.24801904
82Congenital hepatic fibrosis (HP:0002612)2.24513469
83Aplasia/Hypoplasia of the tongue (HP:0010295)2.24035161
84Inability to walk (HP:0002540)2.23940413
85Fair hair (HP:0002286)2.23848416
86Male pseudohermaphroditism (HP:0000037)2.22363936
87Febrile seizures (HP:0002373)2.20096353
88Exertional dyspnea (HP:0002875)2.20024229
89CNS demyelination (HP:0007305)2.19418447
90Respiratory difficulties (HP:0002880)2.19311125
91Abnormal respiratory motile cilium physiology (HP:0012261)2.16590637
92Poor suck (HP:0002033)2.16053980
93X-linked dominant inheritance (HP:0001423)2.15075765
94Type II lissencephaly (HP:0007260)2.10671951
95Renal cortical cysts (HP:0000803)2.10468884
96Aplasia/Hypoplasia of the tibia (HP:0005772)2.09062487
97Polyuria (HP:0000103)2.08915347
98Absent speech (HP:0001344)2.04555985
99Lissencephaly (HP:0001339)2.01952834
100Limb dystonia (HP:0002451)2.01638522
101Postaxial foot polydactyly (HP:0001830)2.00952703
102Congenital sensorineural hearing impairment (HP:0008527)1.98300805
103Macrocytic anemia (HP:0001972)1.97713727
104Abnormal pupillary function (HP:0007686)1.96597618
105Anxiety (HP:0000739)1.95714822
106Congenital, generalized hypertrichosis (HP:0004540)1.95613570
107Bony spicule pigmentary retinopathy (HP:0007737)1.95079461
108Rhinitis (HP:0012384)1.95056278
109Chorioretinal atrophy (HP:0000533)1.93966110
110Poor coordination (HP:0002370)1.93159423
111Lethargy (HP:0001254)1.92717419
112Absence seizures (HP:0002121)1.91570572
113True hermaphroditism (HP:0010459)1.90292787
114Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89684423
115Abnormal protein N-linked glycosylation (HP:0012347)1.89684423
116Abnormal protein glycosylation (HP:0012346)1.89684423
117Abnormal glycosylation (HP:0012345)1.89684423
118Focal seizures (HP:0007359)1.88740346
119Palpitations (HP:0001962)1.86590016
120Thyroid-stimulating hormone excess (HP:0002925)1.86185157
121Cerebellar dysplasia (HP:0007033)1.85960965
122Ketoacidosis (HP:0001993)1.82298782
123Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.82252781
124Reticulocytopenia (HP:0001896)1.81954078
125Aplastic anemia (HP:0001915)1.81683461
126Increased corneal curvature (HP:0100692)1.81398009
127Keratoconus (HP:0000563)1.81398009
128Vaginal atresia (HP:0000148)1.80760794
129Ketosis (HP:0001946)1.80649810
130Abnormal biliary tract physiology (HP:0012439)1.80193952
131Bile duct proliferation (HP:0001408)1.80193952
132Split foot (HP:0001839)1.79657210
133Polyphagia (HP:0002591)1.79644144
134Reduced antithrombin III activity (HP:0001976)1.79638574
135Genital tract atresia (HP:0001827)1.79424032
136Delusions (HP:0000746)1.78545743
137Autoamputation (HP:0001218)1.77940448
138Abnormality of the renal collecting system (HP:0004742)1.77854925
139Abnormality of the pons (HP:0007361)1.77384963
140Cerebral hypomyelination (HP:0006808)1.76568216
141Myokymia (HP:0002411)1.76055817
142Hemiparesis (HP:0001269)1.75685408
143Methylmalonic aciduria (HP:0012120)1.75527969
144Generalized aminoaciduria (HP:0002909)1.75381962
145Progressive inability to walk (HP:0002505)1.75161325
146Hypoplasia of the pons (HP:0012110)1.74746728
147Degeneration of the lateral corticospinal tracts (HP:0002314)1.74692204
148Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74692204
149Aplasia/hypoplasia of the uterus (HP:0008684)1.73617412
150Pancreatic cysts (HP:0001737)1.73490144
151Broad-based gait (HP:0002136)1.73051522
152Postnatal microcephaly (HP:0005484)1.72568550
153Abnormality of midbrain morphology (HP:0002418)1.72205516
154Molar tooth sign on MRI (HP:0002419)1.72205516
155Gonadotropin excess (HP:0000837)1.71087257
156Widely spaced teeth (HP:0000687)1.70699342
157Dialeptic seizures (HP:0011146)1.69894192
158Generalized hypopigmentation of hair (HP:0011358)1.69176518
159Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68493717
160Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68162350
161Stomach cancer (HP:0012126)1.68132671
162Abnormality of macular pigmentation (HP:0008002)1.66879260
163Postaxial hand polydactyly (HP:0001162)1.64703786
164Patellar aplasia (HP:0006443)1.64659672
165Optic nerve hypoplasia (HP:0000609)1.63933310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.89224285
2CAMKK24.65067324
3STK163.71638866
4CASK3.20930499
5MAP3K122.81561097
6CDK192.79900405
7WNK32.45683118
8NME12.39932504
9MUSK2.30086837
10TAOK32.26603442
11TNIK2.19808303
12ZAK2.16728582
13GRK71.96952696
14ARAF1.96486613
15MAPKAPK51.96226430
16MAP2K71.95002233
17NUAK11.93394683
18PDK31.88242901
19PDK41.88242901
20BUB11.84366245
21ADRBK21.79000235
22MAP4K21.78353296
23OXSR11.75368574
24VRK11.73554509
25INSRR1.65111917
26TXK1.64802525
27STK391.62739172
28MST41.57806367
29RIPK41.55789660
30CAMK1D1.55759441
31PNCK1.47950384
32NME21.46017074
33WEE11.40946639
34GRK51.32961613
35WNK41.32411788
36TSSK61.30803991
37DAPK21.29819489
38MKNK21.23876204
39CCNB11.21769682
40CAMK2B1.20114808
41LMTK21.20061116
42BMPR21.19711989
43PINK11.18555431
44MYLK1.16767577
45SIK31.16717949
46NTRK31.15221689
47PIK3CA1.13099271
48CAMK1G1.12722689
49TNK21.09361824
50EPHA41.09064289
51PLK21.08327221
52PTK2B1.07855255
53CAMK2D1.06105775
54CAMK11.04480912
55PAK31.03833363
56ADRBK11.00582664
57CAMKK10.98644412
58CSNK1G30.96982239
59MAP3K40.95777591
60ACVR1B0.95305794
61MINK10.90539186
62PRKCG0.89824028
63BMPR1B0.89109446
64BRSK20.87731206
65MAP3K90.87719414
66BRAF0.86731493
67CAMK2A0.85319229
68CAMK2G0.84890263
69SGK20.84450110
70BCR0.83822705
71NLK0.83471797
72PIK3CG0.81233665
73BRSK10.79883398
74STK110.77832268
75MAPK130.74720070
76STK38L0.74476956
77PRKCE0.73925171
78TESK20.73361016
79TGFBR10.68064410
80IRAK10.68038919
81AKT30.67823658
82IKBKB0.66853284
83DAPK10.66544747
84CSNK1G20.66012916
85PDK20.64896837
86PHKG10.64374704
87PHKG20.64374704
88PRKCQ0.64227675
89UHMK10.64046434
90OBSCN0.63963027
91TLK10.63915312
92MARK30.62351091
93STK30.62273787
94CDK50.61189138
95EIF2AK30.61016079
96FES0.60929807
97MAPKAPK30.59561807
98LIMK10.58393192
99PIM20.55445497
100TEC0.54934138
101ITK0.54805784
102PKN10.54435563
103CSNK1G10.54085780
104NTRK20.53449140
105KIT0.53375002
106BCKDK0.53151555
107PRKAA20.53072056
108BTK0.51399679
109DYRK20.50611398
110MAPK150.50559874
111CDK140.50466151
112SGK2230.49760002
113SGK4940.49760002
114CDK180.47379602
115GRK10.46642860
116RPS6KA50.46558307
117MAP2K60.46198321
118SIK20.45648352
119CHUK0.44712714
120TRPM70.44145997
121CSNK1A10.44145080
122MAP2K40.43946254
123CDK11A0.43750585
124FGFR20.43303468
125CDK150.42620464
126EPHA30.42534918
127PRKACA0.42197061
128PRKG10.41932283
129TRIM280.41380079
130ERBB20.40992376
131MARK10.40297028
132DYRK30.39828601
133PRKAA10.39710141
134CDK30.38847422
135MOS0.38709653
136SCYL20.38531633
137ERBB30.36774510
138FLT30.36041511
139AURKA0.35798627
140CAMK40.35235283
141LYN0.35131114
142EIF2AK10.35071714
143MAP3K70.34991826
144MKNK10.34034905
145SYK0.32859375
146CSNK1A1L0.32369964
147DYRK1A0.30891274
148CSNK2A20.27562761
149PBK0.27475234

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.19302772
2Parkinsons disease_Homo sapiens_hsa050124.47449181
3Alzheimers disease_Homo sapiens_hsa050103.31495452
4Huntingtons disease_Homo sapiens_hsa050163.25283918
5Proteasome_Homo sapiens_hsa030503.12787503
6Ribosome_Homo sapiens_hsa030102.90012358
7Protein export_Homo sapiens_hsa030602.82748891
8Linoleic acid metabolism_Homo sapiens_hsa005912.50843173
9Nitrogen metabolism_Homo sapiens_hsa009102.40956575
10RNA polymerase_Homo sapiens_hsa030202.36072179
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.35660551
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.35010473
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.29830287
14Cardiac muscle contraction_Homo sapiens_hsa042602.26050779
15Nicotine addiction_Homo sapiens_hsa050332.12849677
16Collecting duct acid secretion_Homo sapiens_hsa049661.98349057
17Caffeine metabolism_Homo sapiens_hsa002321.90514956
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72602310
19Tryptophan metabolism_Homo sapiens_hsa003801.72087905
20Sulfur metabolism_Homo sapiens_hsa009201.68700715
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67715101
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58670267
23Fatty acid elongation_Homo sapiens_hsa000621.58664626
24Synaptic vesicle cycle_Homo sapiens_hsa047211.58181417
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55932587
26Selenocompound metabolism_Homo sapiens_hsa004501.54004523
27Vibrio cholerae infection_Homo sapiens_hsa051101.53457393
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52470400
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.52272960
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.51807209
31ABC transporters_Homo sapiens_hsa020101.49477792
32Chemical carcinogenesis_Homo sapiens_hsa052041.45026420
33Pyrimidine metabolism_Homo sapiens_hsa002401.41750664
34Purine metabolism_Homo sapiens_hsa002301.35417325
35Taste transduction_Homo sapiens_hsa047421.32494701
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29849742
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.29496515
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28781665
39Pyruvate metabolism_Homo sapiens_hsa006201.28222480
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28172434
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21631011
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.17053119
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16618211
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16222948
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15878822
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15443647
47Retinol metabolism_Homo sapiens_hsa008301.14154603
48Mismatch repair_Homo sapiens_hsa034301.13951162
49Propanoate metabolism_Homo sapiens_hsa006401.13879511
50Serotonergic synapse_Homo sapiens_hsa047261.13456209
51Amphetamine addiction_Homo sapiens_hsa050311.12787766
52GABAergic synapse_Homo sapiens_hsa047271.10658351
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09586083
54Morphine addiction_Homo sapiens_hsa050321.08763898
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06888528
56Glycerolipid metabolism_Homo sapiens_hsa005611.05957463
57Primary immunodeficiency_Homo sapiens_hsa053401.05504428
58Regulation of autophagy_Homo sapiens_hsa041401.02214106
59DNA replication_Homo sapiens_hsa030301.01921057
60beta-Alanine metabolism_Homo sapiens_hsa004100.98335414
61Ovarian steroidogenesis_Homo sapiens_hsa049130.98071269
62Homologous recombination_Homo sapiens_hsa034400.97080633
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96636936
64Circadian entrainment_Homo sapiens_hsa047130.95462402
65Olfactory transduction_Homo sapiens_hsa047400.94857581
66Glutamatergic synapse_Homo sapiens_hsa047240.92901996
67Calcium signaling pathway_Homo sapiens_hsa040200.91989044
68Metabolic pathways_Homo sapiens_hsa011000.91911099
69Asthma_Homo sapiens_hsa053100.89424643
70One carbon pool by folate_Homo sapiens_hsa006700.89044903
71Nucleotide excision repair_Homo sapiens_hsa034200.88413663
72Histidine metabolism_Homo sapiens_hsa003400.88253371
73Vitamin B6 metabolism_Homo sapiens_hsa007500.87308049
74Insulin secretion_Homo sapiens_hsa049110.84699819
75Pentose phosphate pathway_Homo sapiens_hsa000300.84606960
76Basal transcription factors_Homo sapiens_hsa030220.84475071
77Circadian rhythm_Homo sapiens_hsa047100.83470932
78Dopaminergic synapse_Homo sapiens_hsa047280.81989433
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80113769
80Type I diabetes mellitus_Homo sapiens_hsa049400.77369318
81Non-homologous end-joining_Homo sapiens_hsa034500.75079732
82Salivary secretion_Homo sapiens_hsa049700.74972087
83Glutathione metabolism_Homo sapiens_hsa004800.72598393
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.71586007
85Butanoate metabolism_Homo sapiens_hsa006500.68895984
86Long-term potentiation_Homo sapiens_hsa047200.68110697
87Phototransduction_Homo sapiens_hsa047440.67894235
88Dorso-ventral axis formation_Homo sapiens_hsa043200.67881048
89Folate biosynthesis_Homo sapiens_hsa007900.66147585
90Graft-versus-host disease_Homo sapiens_hsa053320.64692903
91Autoimmune thyroid disease_Homo sapiens_hsa053200.64575123
92Carbon metabolism_Homo sapiens_hsa012000.64468969
93Cocaine addiction_Homo sapiens_hsa050300.62261939
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62017323
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61683911
96Renin secretion_Homo sapiens_hsa049240.60479152
97RNA degradation_Homo sapiens_hsa030180.60359075
98cAMP signaling pathway_Homo sapiens_hsa040240.59509277
99Allograft rejection_Homo sapiens_hsa053300.58308864
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57056867
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54585452
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54033164
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53699131
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53251904
105Oocyte meiosis_Homo sapiens_hsa041140.52874979
106Platelet activation_Homo sapiens_hsa046110.52741763
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52248557
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50895478
109Gastric acid secretion_Homo sapiens_hsa049710.50336916
110Arachidonic acid metabolism_Homo sapiens_hsa005900.50329177
111Sphingolipid metabolism_Homo sapiens_hsa006000.49533239
112Ether lipid metabolism_Homo sapiens_hsa005650.49262135
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49159594
114Long-term depression_Homo sapiens_hsa047300.48980263
115Type II diabetes mellitus_Homo sapiens_hsa049300.48966985
116Mineral absorption_Homo sapiens_hsa049780.47329666
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47144258
118Fatty acid degradation_Homo sapiens_hsa000710.46589959
119Spliceosome_Homo sapiens_hsa030400.46391970
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46334624
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44593460
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.43700988
123Fat digestion and absorption_Homo sapiens_hsa049750.43594567
124N-Glycan biosynthesis_Homo sapiens_hsa005100.41233942
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41181554
126Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40315028
127Cholinergic synapse_Homo sapiens_hsa047250.39094561
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37825388
129Fanconi anemia pathway_Homo sapiens_hsa034600.37169807
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37085109
131Peroxisome_Homo sapiens_hsa041460.36422669
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.35305179
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34863977
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30276983
135RNA transport_Homo sapiens_hsa030130.30019305
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.29549402
137Alcoholism_Homo sapiens_hsa050340.29534250
138Pancreatic secretion_Homo sapiens_hsa049720.28089979
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.25420347
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24966247
141Rheumatoid arthritis_Homo sapiens_hsa053230.23937541
142Fructose and mannose metabolism_Homo sapiens_hsa000510.21940069
143Oxytocin signaling pathway_Homo sapiens_hsa049210.21238324
144Vascular smooth muscle contraction_Homo sapiens_hsa042700.20924733
145Tyrosine metabolism_Homo sapiens_hsa003500.19892188

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